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General Information
Symbol
Dmel\Orco
Species
D. melanogaster
Name
Odorant receptor co-receptor
Annotation Symbol
CG10609
Feature Type
FlyBase ID
FBgn0037324
Gene Model Status
Stock Availability
Gene Snapshot
Odorant receptor co-receptor (Orco) encodes a broadly expressed in the chemosensory organs, where it forms heteromultimeric complexes with ligand-selective odorant receptors (ORs). It serves dual role as a chaperone for cell surface expression of the OR/Orco complex as well as being integral to the function of the olfactory receptor complex. It does not itself respond to olfactory ligands, but is thought to contribute to the putative ion-conducting pore. [Date last reviewed: 2019-03-14]
Also Known As

Or83b

Key Links
Genomic Location
Cytogenetic map
Sequence location
3R:5,407,183..5,412,406 [-]
Recombination map

3-47.5

RefSeq locus
NT_033777 REGION:5407183..5412406
Sequence
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (16 terms)
Molecular Function (5 terms)
Terms Based on Experimental Evidence (5 terms)
CV Term
Evidence
References
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
inferred from sequence model
inferred from sequence or structural similarity with FLYBASE:Or43b; FB:FBgn0026393
inferred from biological aspect of ancestor with PANTHER:PTN000474402
(assigned by GO_Central )
Biological Process (6 terms)
Terms Based on Experimental Evidence (6 terms)
CV Term
Evidence
References
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
inferred from biological aspect of ancestor with PANTHER:PTN000474402
(assigned by GO_Central )
non-traceable author statement
traceable author statement
Cellular Component (5 terms)
Terms Based on Experimental Evidence (3 terms)
CV Term
Evidence
References
inferred from direct assay
colocalizes_with cilium
inferred from direct assay
inferred from direct assay
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
inferred from sequence or structural similarity with FLYBASE:Or22a; FB:FBgn0026398
inferred from biological aspect of ancestor with PANTHER:PTN000474402
(assigned by GO_Central )
inferred from biological aspect of ancestor with PANTHER:PTN000474402
(assigned by GO_Central )
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the insect chemoreceptor superfamily. Heteromeric odorant receptor channel (TC 1.A.69) family. Orco subfamily. (Q9VNB5)
Protein Signatures (InterPro)
Summaries
Gene Group (FlyBase)
ODORANT RECEPTORS -
Insect odorant receptors (ORs) are a family of chemoreceptors activated by volatile chemicals. ORs form heteromeric complexes, believed to function as non-selective cation channels, comprising an OR and the co-receptor Orco. ORs are expressed in the dendrites of subsets of olfactory neurons in the antenna and maxillary palp. (Adapted from FBrf0168007 and FBrf0220463).
Protein Function (UniProtKB)
Odorant coreceptor which complexes with conventional odorant receptors (ORs) to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability. Orco is a universal and integral part of the functional odorant receptor, involved in the dendritic localization of other olfactory receptors. Expression of Orco alone leads to formation of rapid and transient ion channels not directly responding to odorants, but directly activated by intracellular cAMP or cGMP. Snmp, Or67d and lush act in concert to capture fatty-acid-derived male pheromone 11-cis vaccenyl acetate (cVA) molecules on the surface of Or67d expressing olfactory dendrites and facilitate their transfer to the odorant-receptor Orco complex.
(UniProt, Q9VNB5)
Summary (Interactive Fly)

7 TM odorant receptor - broadly expressed receptor of unknown function - required for dendritic localization of conventional odorant receptors - mutation disrupts behavioral and electorphysiological responses to many odorants

Gene Model and Products
Number of Transcripts
2
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\Orco for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Gene model as per FBrf0136024

Gene model reviewed during 5.47

Sequence Ontology: Class of Gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
FBtr0078794
1929
486
FBtr0113193
1743
486
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
FBpp0078438
54.4
486
8.65
FBpp0112105
54.4
486
8.65
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

486 aa isoforms: Orco-PA, Orco-PB
Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Subunit Structure (UniProtKB)

Heterodimer with conventional odorant receptors (ORs). Complexes exist early in the endomembrane system in olfactory sensory neurons (OSNs), coupling these complexes to the conserved ciliary trafficking pathway.

(UniProt, Q9VNB5)
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Orco using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
RT-PCR
Stage
Tissue/Position (including subcellular localization)
Reference
Additional Descriptive Data

Orco transcript is observed in the neurons of the basiconicum, trichodeum and coeloconic sensilla ac3 of the third segment of the antenna. In sensillum ac3 it is co-expressed with Ir75a, Ir75b, Or35a and Ir76b.

Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
inferred from direct assay
colocalizes_with cilium
inferred from direct assay
inferred from direct assay
Expression Deduced from Reporters
Reporter: P{Orco-GAL4.7.087}
Stage
Tissue/Position (including subcellular localization)
Reference
Reporter: P{Orco-GAL4.C}
Stage
Tissue/Position (including subcellular localization)
Reference
Reporter: P{Orco-GAL4.K}
Stage
Tissue/Position (including subcellular localization)
Reference
Reporter: P{Orco-GAL4.W}
Stage
Tissue/Position (including subcellular localization)
Reference
Reporter: P{Orco-LexA-VP16}
Stage
Tissue/Position (including subcellular localization)
Reference
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Orco in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Flygut - An atlas of the Drosophila adult midgut
Images
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 7 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 32 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Orco
Transgenic constructs containing regulatory region of Orco
Deletions and Duplications ( 1 )
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
Other Phenotypes
Allele
Phenotype manifest in
Allele
Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (0)
No records found.
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (0)
No records found.
Rattus norvegicus (Norway rat) (0)
No records found.
Xenopus tropicalis (Western clawed frog) (0)
No records found.
Danio rerio (Zebrafish) (0)
No records found.
Caenorhabditis elegans (Nematode, roundworm) (0)
No records found.
Arabidopsis thaliana (thale-cress) (0)
No records found.
Saccharomyces cerevisiae (Brewer's yeast) (0)
No records found.
Schizosaccharomyces pombe (Fission yeast) (0)
No records found.
Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG091906YA )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila suzukii
Spotted wing Drosophila
Drosophila simulans
Drosophila sechellia
Drosophila erecta
Drosophila yakuba
Drosophila ananassae
Drosophila ananassae
Drosophila pseudoobscura pseudoobscura
Drosophila persimilis
Drosophila willistoni
Drosophila virilis
Drosophila mojavensis
Drosophila grimshawi
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091505QL )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Musca domestica
House fly
Glossina morsitans
Tsetse fly
Mayetiola destructor
Hessian fly
Mayetiola destructor
Hessian fly
Aedes aegypti
Yellow fever mosquito
Anopheles darlingi
American malaria mosquito
Anopheles gambiae
Malaria mosquito
Culex quinquefasciatus
Southern house mosquito
Culex quinquefasciatus
Southern house mosquito
Culex quinquefasciatus
Southern house mosquito
Culex quinquefasciatus
Southern house mosquito
Culex quinquefasciatus
Southern house mosquito
Culex quinquefasciatus
Southern house mosquito
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W050M )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Danaus plexippus
Monarch butterfly
Heliconius melpomene
Postman butterfly
Apis florea
Little honeybee
Apis mellifera
Western honey bee
Bombus impatiens
Common eastern bumble bee
Bombus terrestris
Buff-tailed bumblebee
Linepithema humile
Argentine ant
Linepithema humile
Argentine ant
Megachile rotundata
Alfalfa leafcutting bee
Nasonia vitripennis
Parasitic wasp
Dendroctonus ponderosae
Mountain pine beetle
Tribolium castaneum
Red flour beetle
Pediculus humanus
Human body louse
Rhodnius prolixus
Kissing bug
Cimex lectularius
Bed bug
Acyrthosiphon pisum
Pea aphid
Zootermopsis nevadensis
Nevada dampwood termite
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( None identified )
No non-Insect Arthropod orthologies identified
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( None identified )
No non-Arthropod Metazoa orthologies identified
Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (59)
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Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 1 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    Functional Complementation Data
    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
    Interactions
    Summary of Physical Interactions
    Summary of Genetic Interactions
    esyN Network Diagram
    esyN Network Key:
    Suppression
    Enhancement

    Please look at the allele data for full details of the genetic interactions
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    External Data
    Subunit Structure (UniProtKB)
    Heterodimer with conventional odorant receptors (ORs). Complexes exist early in the endomembrane system in olfactory sensory neurons (OSNs), coupling these complexes to the conserved ciliary trafficking pathway.
    (UniProt, Q9VNB5 )
    Linkouts
    DroID - A comprehensive database of gene and protein interactions.
    InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
    MIST (protein-protein) - An integrated Molecular Interaction Database
    Pathways
    Signaling Pathways (FlyBase)
    Metabolic Pathways
    External Data
    Linkouts
    Genomic Location and Detailed Mapping Data
    Chromosome (arm)
    3R
    Recombination map

    3-47.5

    Cytogenetic map
    Sequence location
    3R:5,407,183..5,412,406 [-]
    FlyBase Computed Cytological Location
    Cytogenetic map
    Evidence for location
    83A2-83A2
    Limits computationally determined from genome sequence between P{EP}EP974 and P{PZ}Snr101319&P{PZ}Itp-r83A05616
    Experimentally Determined Cytological Location
    Cytogenetic map
    Notes
    References
    Experimentally Determined Recombination Data
    Location
    Left of (cM)
    Right of (cM)
    Notes
    Stocks and Reagents
    Stocks (11)
    Genomic Clones (28)
    cDNA Clones (11)
     

    Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

    cDNA clones, fully sequenced
    BDGP DGC clones
    Other clones
    Drosophila Genomics Resource Center cDNA clones

    For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

    cDNA Clones, End Sequenced (ESTs)
    BDGP DGC clones
      RNAi and Array Information
      Linkouts
      DRSC - Results frm RNAi screens
      GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
      Antibody Information
      Laboratory Generated Antibodies
       

      polyclonal

      Commercially Available Antibodies
       
      Other Information
      Relationship to Other Genes
      Source for database identify of

      Source for identity of: Or83b CG10609

      Source for identity of: Orco Or83b

      Source for database merge of
      Additional comments
      Other Comments

      The Or83b product is required to maintain odorant receptor localization and stability.

      Origin and Etymology
      Discoverer
      Etymology
      Identification
      External Crossreferences and Linkouts ( 29 )
      Sequence Crossreferences
      NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
      GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
      GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
      RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
      UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
      Other crossreferences
      Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
      Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
      Flygut - An atlas of the Drosophila adult midgut
      GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
      iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
      InterPro - A database of protein families, domains and functional sites
      KEGG Genes - Molecular building blocks of life in the genomic space.
      modMine - A data warehouse for the modENCODE project
      Linkouts
      DroID - A comprehensive database of gene and protein interactions.
      DRSC - Results frm RNAi screens
      FLIGHT - Cell culture data for RNAi and other high-throughput technologies
      FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
      FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
      FlyMine - An integrated database for Drosophila genomics
      Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
      InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
      MIST (protein-protein) - An integrated Molecular Interaction Database
      Synonyms and Secondary IDs (27)
      Reported As
      Symbol Synonym
      A45
      Or83b
      (Brankatschk et al., 2018, Ganguly et al., 2017, Lone et al., 2016, Murmu and Martin, 2016, Dekker et al., 2015, Del Pino et al., 2015, Sujkowski et al., 2015, Chi et al., 2014, Dipt et al., 2014, Gendron et al., 2014, Honda et al., 2014, Krstic et al., 2013, Leal, 2013, Billeter et al., 2012, Immonen and Ritchie, 2012, Jeong et al., 2012, Linford et al., 2012, Lone and Sharma, 2012, Prieto-Godino et al., 2012, Simon et al., 2012, Deng et al., 2011, Franco et al., 2011, Kazama et al., 2011, Lone and Sharma, 2011, Lone and Sharma, 2011, Niewalda et al., 2011, Störtkuhl and Fiala, 2011, Bellmann et al., 2010, Bhandawat et al., 2010, Foley et al., 2010, Kong et al., 2010, Kwon et al., 2010, Kwon et al., 2010, Larkin et al., 2010, Lee et al., 2010, Mishra et al., 2010, Miyazaki and Ito, 2010, Poon et al., 2010, Wang and Anderson, 2010, Yao and Carlson, 2010, Asahina et al., 2009, Chiang et al., 2009, Krstic et al., 2009, Masuda-Nakagawa et al., 2009, Robertson, 2009, Zhou et al., 2009, Asahina et al., 2008, DasGupta and Waddell, 2008, Ditzen et al., 2008, Hiroi et al., 2008, Hoare et al., 2008, Huang et al., 2008, Jin et al., 2008, Krishnan et al., 2008, Louis et al., 2008, Olsen and Wilson, 2008, Poon et al., 2008, Sambandan et al., 2008, Sato et al., 2008, Smart et al., 2008, Wicher et al., 2008, Benton et al., 2007, Benton et al., 2007, Fujii et al., 2007, Grillenzoni et al., 2007, Guo and Kim, 2007, Jones et al., 2007, Kwon et al., 2007, Leslie, 2007, Libert et al., 2007, McBride et al., 2007, Olsen et al., 2007, Sachse et al., 2007, Bargmann, 2006, de Bruyne and Warr, 2006, Kamikouchi et al., 2006, Lai and Lee, 2006, Morozova et al., 2006, van der Goes van Naters and Carlson, 2006, Kreher et al., 2005, Sen et al., 2005, Robertson et al., 2003)
      Orco
      (Guo et al., 2020, Lucke et al., 2020, Slankster et al., 2020, Batra et al., 2019, Chai et al., 2019, Chakraborty et al., 2019, Kacsoh et al., 2019, Kadakia and Emonet, 2019, Li et al., 2019, Li et al., 2019, Miazzi et al., 2019, Narasimha et al., 2019, Qiao et al., 2019, Rivera et al., 2019, Si et al., 2019, Abu et al., 2018, Alisch et al., 2018, Chin et al., 2018, Halty-deLeon et al., 2018, Jung et al., 2018, Landayan et al., 2018, MacWilliam et al., 2018, Rode et al., 2018, Utashiro et al., 2018, Watanabe et al., 2018, Yu et al., 2018, Cao et al., 2017, Croft et al., 2017, Giang et al., 2017, Guo et al., 2017, Keita et al., 2017, Kim and Dickinson, 2017, Ramdya et al., 2017, Retzke et al., 2017, Bahk and Jones, 2016, Corrales-Carvajal et al., 2016, Dubey et al., 2016, Dweck et al., 2016, Enjin et al., 2016, Getahun et al., 2016, Grabe et al., 2016, Hussain et al., 2016, Newquist et al., 2016, Sarov et al., 2016, Dekker et al., 2015, Del Pino et al., 2015, Dweck et al., 2015, Grotewiel and Bettinger, 2015, Lin et al., 2015, Liu et al., 2015, Proshkina et al., 2015, Slepian et al., 2015, Del Pino et al., 2014, Fişek and Wilson, 2014, Gomez-Marin and Louis, 2014, Grewal et al., 2014, Ha et al., 2014, Kuzhandaivel et al., 2014, Liu et al., 2014, Menuz et al., 2014, Mukunda et al., 2014, Ronderos et al., 2014, Schneider and Levine, 2014, Turner et al., 2014, Ueira-Vieira et al., 2014, Carlsson et al., 2013, Fujita et al., 2013, Garbaczewska et al., 2013, Getahun et al., 2013, Joo et al., 2013, Leal, 2013, Risse et al., 2013, Röllecke et al., 2013, Tan et al., 2013, Wang et al., 2013, Wasserman et al., 2013, Billeter et al., 2012, Nakagawa et al., 2012, Prieto-Godino et al., 2012, Schneider et al., 2012, Schneider et al., 2012, Trott et al., 2012, Gomez-Marin et al., 2011, Hoare et al., 2011, Montague et al., 2011, Nichols et al., 2011, Niewalda et al., 2011, Silbering et al., 2011, Vosshall and Hansson, 2011, Vosshall and Hansson, 2011.1.24, Wang et al., 2011, Wisotsky et al., 2011)
      Name Synonyms
      Odorant receptor 83b
      Odorant receptor co-receptor
      Olfactory coreceptor
      odorant receptor 83b
      odorant receptor co-receptor
      odorant receptor coreceptor
      olfactory co-receptor
      olfactory receptor co-receptor
      Secondary FlyBase IDs
        Datasets (0)
        Study focus (0)
        Experimental Role
        Project
        Project Type
        Title
        References (328)