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Gene Dmel\Orco

General Information
Symbol	Dmel\Orco	Species	D. melanogaster
Name	Odorant receptor co-receptor	Annotation symbol	CG10609
Feature type	protein_coding_gene	FlyBase ID	FBgn0037324
Gene Model Status	Current	Stock availability	7 publicly available
Also Known As	OR83b
Genomic Location
Chromosome (arm)	3R	Recombination map
Cytogenetic map	83A2-83A2	Sequence location	3R:1,232,905..1,238,128 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Odorant receptor co-receptor is referred to in FlyBase by the symbol Dmel\Orco (CG10609, FBgn0037324). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: protein homodimerization activity; olfactory receptor activity. There is experimental evidence that it is involved in the biological process: olfactory behavior; protein heterooligomerization; response to pheromone; behavioral response to ethanol. 27 alleles are reported. The phenotypes of these alleles are annotated with: olfactory receptor neuron; embryonic/larval olfactory receptor neuron; antennal sense organ. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: Olfactory receptor, Drosophila. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of no expression detected. Peak expression observed during late pupal stages, in adult male stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult head. Comments on Affy2 ProbeSet: ProbeSet 1636134_at completely aligns to an exonic region common to each of the 2 FlyBase-annotated transcript isoforms of Or83b. Gene sequence location is 3R:1232905..1238128.
User Contributed Data
	Beta version, feedback welcome
External Summaries
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 83A2-83A2   Limits computationally determined from genome sequence between P{EP}EP974 and P{PZ}Snr101319&P{PZ}Itp-r83A05616
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Orco for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.47 Gene model as per FBrf0136024
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Orco-RA FBtr0078794  NM_079511   1929   486 Orco-RB FBtr0113193  NM_001104217   1743   486
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Orco-PA   FBpp0078438   54.4   486   8.65     NP_524235   AAF52031 Orco-PB   FBpp0112105   54.4   486   8.65     NP_001097687   ABW08603
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Olfactory receptor, Drosophila (IPR004117)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014297 AAF52031   AE014297 ABW08603   AY567998 AAT71306   BT023148   BT128877   CO190568   DD163177   EC051245   EC051749   EC052345   EC054332   EC055839   EC229979   EL871042   EL871043   EL871285   EL871286
UniProtKB/Swiss-Prot	Q9VNB5
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference adult stage   neuron of antennal coeloconic sensillum ac3   (Benton et al., 2009) neuron of sensillum basiconicum of antennal segment 3   (Benton et al., 2009) neuron of sensillum trichodeum of antennal segment 3   (Benton et al., 2009) RT-PCR Stage Tissue/Position (including subcellular localization) Reference adult stage   antenna   (Croset et al., 2010)
Additional Descriptive Data
	Orco transcript is observed in the neurons of the basiconicum, trichodeum and coeloconic sensilla ac3 of the third segment of the antenna. In sensillum ac3 it is co-expressed with Ir75a, Ir75b, Or35a and Ir76b. (Benton et al., 2009)
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization Stage Tissue/Position (including subcellular localization) Reference first instar larval stage   embryonic/larval olfactory receptor neuron   (Prieto-Godino et al., 2012)
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
dendrite inferred from direct assay (Benton et al., 2006) plasma membrane inferred from direct assay (Benton et al., 2006)
Expression Deduced from Reporters
Reporter: P{Orco-GAL4.7.087} Stage Tissue/Position (including subcellular localization) Reference adult stage   olfactory receptor neuron of maxillary palpus | subset   (Yu et al., 2004) antenna   (Hallem et al., 2004, Yu et al., 2004) olfactory receptor neuron of maxillary palpus   (Hallem et al., 2004) olfactory receptor neuron of antenna | subset   (Yu et al., 2004) olfactory receptor neuron of antenna   (Hallem et al., 2004) maxillary palpus   (Hallem et al., 2004, Yu et al., 2004) olfactory receptor neuron | subset   (Hallem et al., 2004, Ng et al., 2002, Yu et al., 2004) maxillary palp olfactory receptor neuron | subset   (Hallem et al., 2004) antennal olfactory receptor neuron | subset   (Hallem et al., 2004) adult antennal lobe glomerulus | subset   (Yu et al., 2004, Ng et al., 2002) Reporter: P{Orco-GAL4.W} Stage Tissue/Position (including subcellular localization) Reference larval stage   embryonic/larval olfactory receptor neuron | restricted   (Masuda-Nakagawa et al., 2009) adult stage   olfactory receptor neuron of sensillum basiconicum of antennal segment 3 | subset   (Tanoue et al., 2004) olfactory receptor neuron of maxillary palp sensillum basiconicum | subset   (Tanoue et al., 2004) maxillary palp sensillum basiconicum | subset   (Tanoue et al., 2004) olfactory receptor neuron | subset   (Wang et al., 2003, Tanoue et al., 2004, Suh et al., 2004, Root et al., 2008) sensillum basiconicum of antennal segment 3 | subset   (Tanoue et al., 2004) adult olfactory receptor neuron | subset   (Shang et al., 2007, Suh et al., 2004) adult olfactory receptor neuron Or22   (Shang et al., 2007) adult olfactory receptor neuron Or47a   (Shang et al., 2007) adult olfactory receptor neuron Or92a   (Shang et al., 2007) adult olfactory receptor neuron   (Kain et al., 2008) antenna | restricted   (Kain et al., 2008, Root et al., 2008) third segment of antenna | restricted   (Kain et al., 2008) maxillary palpus | restricted   (Root et al., 2008) adult antennal lobe | restricted   (Root et al., 2008) adult antennal lobe glomerulus | subset   (Wang et al., 2003)
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult head. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    5.1 Larval Midgut    9.5 Larval Hindgut    9.9 Larval Malpighian Tubules    10 Larval Fat Body    16.6 Larval Salivary Gland    9.6 Larval Trachea    2.05 Larval Carcass    6.25 Adult Head    171.4 Adult Eye    16.275 Adult Brain    14.2 Adult Thoracic-Abdominal Ganglion    15.4 Adult Crop    6.2 Adult Midgut    15.7 Adult Hindgut    8 Adult Malpighian Tubules    5.6 Adult Fat Body    8.1 Adult Salivary Gland    11.1 Adult Heart    3.875 Adult VirginFemale Spermatheca    4 Adult InseminatedFemale Spermatheca    6 Adult Ovary    5.4 Adult Testis    6.2 Adult Male Accessory Gland    17.4 Adult Carcass    13 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    5.1 Larval Midgut    9.5 Larval Hindgut    9.9 Larval Malpighian Tubules    10 Larval Fat Body    16.6 Larval Salivary Gland    9.6 Larval Trachea    2.05 Larval Carcass    6.25 Adult Head    171.4 Adult Eye    16.275 Adult Brain    14.2 Adult Thoracic-Abdominal Ganglion    15.4 Adult Crop    6.2 Adult Midgut    15.7 Adult Hindgut    8 Adult Malpighian Tubules    5.6 Adult Fat Body    8.1 Adult Salivary Gland    11.1 Adult Heart    3.875 Adult VirginFemale Spermatheca    4 Adult InseminatedFemale Spermatheca    6 Adult Ovary    5.4 Adult Testis    6.2 Adult Male Accessory Gland    17.4 Adult Carcass    13 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    5.1 Larval Midgut    9.5 Larval Hindgut    9.9 Larval Malpighian Tubules    10 Larval Fat Body    16.6 Larval Salivary Gland    9.6 Larval Trachea    2.05 Larval Carcass    6.25 Adult Head    171.4 Adult Eye    16.275 Adult Brain    14.2 Adult Thoracic-Abdominal Ganglion    15.4 Adult Crop    6.2 Adult Midgut    15.7 Adult Hindgut    8 Adult Malpighian Tubules    5.6 Adult Fat Body    8.1 Adult Salivary Gland    11.1 Adult Heart    3.875 Adult VirginFemale Spermatheca    4 Adult InseminatedFemale Spermatheca    6 Adult Ovary    5.4 Adult Testis    6.2 Adult Male Accessory Gland    17.4 Adult Carcass    13 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    5.1 Larval Midgut    9.5 Larval Hindgut    9.9 Larval Malpighian Tubules    10 Larval Fat Body    16.6 Larval Salivary Gland    9.6 Larval Trachea    2.05 Larval Carcass    6.25 Adult Head    171.4 Adult Eye    16.275 Adult Brain    14.2 Adult Thoracic-Abdominal Ganglion    15.4 Adult Crop    6.2 Adult Midgut    15.7 Adult Hindgut    8 Adult Malpighian Tubules    5.6 Adult Fat Body    8.1 Adult Salivary Gland    11.1 Adult Heart    3.875 Adult VirginFemale Spermatheca    4 Adult InseminatedFemale Spermatheca    6 Adult Ovary    5.4 Adult Testis    6.2 Adult Male Accessory Gland    17.4 Adult Carcass    13 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    5.1 Larval Midgut    9.5 Larval Hindgut    9.9 Larval Malpighian Tubules    10 Larval Fat Body    16.6 Larval Salivary Gland    9.6 Larval Trachea    2.05 Larval Carcass    6.25 Adult Head    171.4 Adult Eye    16.275 Adult Brain    14.2 Adult Thoracic-Abdominal Ganglion    15.4 Adult Crop    6.2 Adult Midgut    15.7 Adult Hindgut    8 Adult Malpighian Tubules    5.6 Adult Fat Body    8.1 Adult Salivary Gland    11.1 Adult Heart    3.875 Adult VirginFemale Spermatheca    4 Adult InseminatedFemale Spermatheca    6 Adult Ovary    5.4 Adult Testis    6.2 Adult Male Accessory Gland    17.4 Adult Carcass    13 Expression Level Scale  None   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    5.1 Larval Midgut    9.5 Larval Hindgut    9.9 Larval Malpighian Tubules    10 Larval Fat Body    16.6 Larval Salivary Gland    9.6 Larval Trachea    2.05 Larval Carcass    6.25 Adult Head    171.4 Adult Eye    16.275 Adult Brain    14.2 Adult Thoracic-Abdominal Ganglion    15.4 Adult Crop    6.2 Adult Midgut    15.7 Adult Hindgut    8 Adult Malpighian Tubules    5.6 Adult Fat Body    8.1 Adult Salivary Gland    11.1 Adult Heart    3.875 Adult VirginFemale Spermatheca    4 Adult InseminatedFemale Spermatheca    6 Adult Ovary    5.4 Adult Testis    6.2 Adult Male Accessory Gland    17.4 Adult Carcass    13 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    5.1 Larval Midgut    9.5 Larval Hindgut    9.9 Larval Malpighian Tubules    10 Larval Fat Body    16.6 Larval Salivary Gland    9.6 Larval Trachea    2.05 Larval Carcass    6.25 Adult Head    171.4 Adult Eye    16.275 Adult Brain    14.2 Adult Thoracic-Abdominal Ganglion    15.4 Adult Crop    6.2 Adult Midgut    15.7 Adult Hindgut    8 Adult Malpighian Tubules    5.6 Adult Fat Body    8.1 Adult Salivary Gland    11.1 Adult Heart    3.875 Adult VirginFemale Spermatheca    4 Adult InseminatedFemale Spermatheca    6 Adult Ovary    5.4 Adult Testis    6.2 Adult Male Accessory Gland    17.4 Adult Carcass    13 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    5.1 Larval Midgut    9.5 Larval Hindgut    9.9 Larval Malpighian Tubules    10 Larval Fat Body    16.6 Larval Salivary Gland    9.6 Larval Trachea    2.05 Larval Carcass    6.25 Adult Head    171.4 Adult Eye    16.275 Adult Brain    14.2 Adult Thoracic-Abdominal Ganglion    15.4 Adult Crop    6.2 Adult Midgut    15.7 Adult Hindgut    8 Adult Malpighian Tubules    5.6 Adult Fat Body    8.1 Adult Salivary Gland    11.1 Adult Heart    3.875 Adult VirginFemale Spermatheca    4 Adult InseminatedFemale Spermatheca    6 Adult Ovary    5.4 Adult Testis    6.2 Adult Male Accessory Gland    17.4 Adult Carcass    13 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    171.4   NA  Eye    no informative data   NA  Brain    14.2   5.1  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    no informative data   NA  Crop    6.2   9.5  Midgut    no informative data   9.9  Hindgut    8   no informative data  Malpighian Tubules    5.6   no informative data  Fat Body    8.1   9.6  Salivary Gland    no informative data   NA  Heart    3.875   2.05  Trachea    NA   NA  VirginFemale Spermatheca    4   NA  InseminatedFemale Spermatheca    6   NA  Ovary    5.4   NA  Testis    6.2   NA  Male Accessory Gland    no informative data   6.25  Carcass    no informative data FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    0 central nervous system, larvae L3    0 central nervous system, pupae P8    0 head, virgin 1-day female    0 head, virgin 4-day female    1 head, virgin 20-day female    0 head, mated 1-day female    1 head, mated 4-day female    0 head, mated 20-day female    0 head, mated 1-day male    1 head, mated 4-day male    1 head, mated 20-day male    1 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    1 fat body, white prepupae    0 fat body, pupae P8    0 carcass, larvae L3 wandering    0 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    0 central nervous system, larvae L3    0 central nervous system, pupae P8    0 head, virgin 1-day female    0 head, virgin 4-day female    1 head, virgin 20-day female    0 head, mated 1-day female    1 head, mated 4-day female    0 head, mated 20-day female    0 head, mated 1-day male    1 head, mated 4-day male    1 head, mated 20-day male    1 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    1 fat body, white prepupae    0 fat body, pupae P8    0 carcass, larvae L3 wandering    0 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    0 central nervous system, larvae L3    0 central nervous system, pupae P8    0 head, virgin 1-day female    0 head, virgin 4-day female    1 head, virgin 20-day female    0 head, mated 1-day female    1 head, mated 4-day female    0 head, mated 20-day female    0 head, mated 1-day male    1 head, mated 4-day male    1 head, mated 20-day male    1 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    1 fat body, white prepupae    0 fat body, pupae P8    0 carcass, larvae L3 wandering    0 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    0 central nervous system, larvae L3    0 central nervous system, pupae P8    0 head, virgin 1-day female    0 head, virgin 4-day female    1 head, virgin 20-day female    0 head, mated 1-day female    1 head, mated 4-day female    0 head, mated 20-day female    0 head, mated 1-day male    1 head, mated 4-day male    1 head, mated 20-day male    1 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    1 fat body, white prepupae    0 fat body, pupae P8    0 carcass, larvae L3 wandering    0 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    0 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    0 central nervous system, larvae L3    0 central nervous system, pupae P8    0 head, virgin 1-day female    0 head, virgin 4-day female    1 head, virgin 20-day female    0 head, mated 1-day female    1 head, mated 4-day female    0 head, mated 20-day female    0 head, mated 1-day male    1 head, mated 4-day male    1 head, mated 20-day male    1 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    1 fat body, white prepupae    0 fat body, pupae P8    0 carcass, larvae L3 wandering    0 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    0 central nervous system, larvae L3    0 central nervous system, pupae P8    0 head, virgin 1-day female    0 head, virgin 4-day female    1 head, virgin 20-day female    0 head, mated 1-day female    1 head, mated 4-day female    0 head, mated 20-day female    0 head, mated 1-day male    1 head, mated 4-day male    1 head, mated 20-day male    1 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    1 fat body, white prepupae    0 fat body, pupae P8    0 carcass, larvae L3 wandering    0 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    0 central nervous system, larvae L3    0 central nervous system, pupae P8    0 head, virgin 1-day female    0 head, virgin 4-day female    1 head, virgin 20-day female    0 head, mated 1-day female    1 head, mated 4-day female    0 head, mated 20-day female    0 head, mated 1-day male    1 head, mated 4-day male    1 head, mated 20-day male    1 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    1 fat body, white prepupae    0 fat body, pupae P8    0 carcass, larvae L3 wandering    0 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    0 central nervous system, larvae L3    0 central nervous system, pupae P8    0 head, virgin 1-day female    0 head, virgin 4-day female    1 head, virgin 20-day female    0 head, mated 1-day female    1 head, mated 4-day female    0 head, mated 20-day female    0 head, mated 1-day male    1 head, mated 4-day male    1 head, mated 20-day male    1 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    1 fat body, white prepupae    0 fat body, pupae P8    0 carcass, larvae L3 wandering    0 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of no expression detected. Peak expression observed during late pupal stages, in adult male stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    1 embryo 16-18hr    3 embryo 18-20hr    2 embryo 20-22hr    2 embryo 22-24hr    2 larva L1    2 larva L2    1 larva L3 12hr old    0 larva L3 puffstage 1-2    1 larva L3 puffstage 3-6    0 larva L3 puffstage 7-9    0 white prepupae new    0 white prepupae 12hr    0 white prepupae 24hr    0 pupae 2d postWPP    0 pupae 3d postWPP    0 pupae 4d postWPP    7 adult male 01day    5 adult male 05day    6 adult male 30day    13 adult female 01day    2 adult female 05day    1 adult female 30day    2 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    1 embryo 16-18hr    3 embryo 18-20hr    2 embryo 20-22hr    2 embryo 22-24hr    2 larva L1    2 larva L2    1 larva L3 12hr old    0 larva L3 puffstage 1-2    1 larva L3 puffstage 3-6    0 larva L3 puffstage 7-9    0 white prepupae new    0 white prepupae 12hr    0 white prepupae 24hr    0 pupae 2d postWPP    0 pupae 3d postWPP    0 pupae 4d postWPP    7 adult male 01day    5 adult male 05day    6 adult male 30day    13 adult female 01day    2 adult female 05day    1 adult female 30day    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    1 embryo 16-18hr    3 embryo 18-20hr    2 embryo 20-22hr    2 embryo 22-24hr    2 larva L1    2 larva L2    1 larva L3 12hr old    0 larva L3 puffstage 1-2    1 larva L3 puffstage 3-6    0 larva L3 puffstage 7-9    0 white prepupae new    0 white prepupae 12hr    0 white prepupae 24hr    0 pupae 2d postWPP    0 pupae 3d postWPP    0 pupae 4d postWPP    7 adult male 01day    5 adult male 05day    6 adult male 30day    13 adult female 01day    2 adult female 05day    1 adult female 30day    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    1 embryo 16-18hr    3 embryo 18-20hr    2 embryo 20-22hr    2 embryo 22-24hr    2 larva L1    2 larva L2    1 larva L3 12hr old    0 larva L3 puffstage 1-2    1 larva L3 puffstage 3-6    0 larva L3 puffstage 7-9    0 white prepupae new    0 white prepupae 12hr    0 white prepupae 24hr    0 pupae 2d postWPP    0 pupae 3d postWPP    0 pupae 4d postWPP    7 adult male 01day    5 adult male 05day    6 adult male 30day    13 adult female 01day    2 adult female 05day    1 adult female 30day    2 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    1 embryo 16-18hr    3 embryo 18-20hr    2 embryo 20-22hr    2 embryo 22-24hr    2 larva L1    2 larva L2    1 larva L3 12hr old    0 larva L3 puffstage 1-2    1 larva L3 puffstage 3-6    0 larva L3 puffstage 7-9    0 white prepupae new    0 white prepupae 12hr    0 white prepupae 24hr    0 pupae 2d postWPP    0 pupae 3d postWPP    0 pupae 4d postWPP    7 adult male 01day    5 adult male 05day    6 adult male 30day    13 adult female 01day    2 adult female 05day    1 adult female 30day    2 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    1 embryo 16-18hr    3 embryo 18-20hr    2 embryo 20-22hr    2 embryo 22-24hr    2 larva L1    2 larva L2    1 larva L3 12hr old    0 larva L3 puffstage 1-2    1 larva L3 puffstage 3-6    0 larva L3 puffstage 7-9    0 white prepupae new    0 white prepupae 12hr    0 white prepupae 24hr    0 pupae 2d postWPP    0 pupae 3d postWPP    0 pupae 4d postWPP    7 adult male 01day    5 adult male 05day    6 adult male 30day    13 adult female 01day    2 adult female 05day    1 adult female 30day    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    1 embryo 16-18hr    3 embryo 18-20hr    2 embryo 20-22hr    2 embryo 22-24hr    2 larva L1    2 larva L2    1 larva L3 12hr old    0 larva L3 puffstage 1-2    1 larva L3 puffstage 3-6    0 larva L3 puffstage 7-9    0 white prepupae new    0 white prepupae 12hr    0 white prepupae 24hr    0 pupae 2d postWPP    0 pupae 3d postWPP    0 pupae 4d postWPP    7 adult male 01day    5 adult male 05day    6 adult male 30day    13 adult female 01day    2 adult female 05day    1 adult female 30day    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    1 embryo 16-18hr    3 embryo 18-20hr    2 embryo 20-22hr    2 embryo 22-24hr    2 larva L1    2 larva L2    1 larva L3 12hr old    0 larva L3 puffstage 1-2    1 larva L3 puffstage 3-6    0 larva L3 puffstage 7-9    0 white prepupae new    0 white prepupae 12hr    0 white prepupae 24hr    0 pupae 2d postWPP    0 pupae 3d postWPP    0 pupae 4d postWPP    7 adult male 01day    5 adult male 05day    6 adult male 30day    13 adult female 01day    2 adult female 05day    1 adult female 30day    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    4 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    2 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    4 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    4 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    4 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    2 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    4 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    2 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    4 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    4 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    4 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    0 cold shock, 4-day adult    0 heat shock, 4-day adult    0 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    0 Cadmium 50 mM 48 hrs, 4-day adult    1 Cadmium 100 mM 48 hrs, 4-day adult    0 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    0 Zinc 5 mM 12 hrs, larvae L3    0 Zinc 4.5 mM 48 hrs, 4-day adult    1 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    0 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    1 Caffeine 25 mg/ml 48 hrs, 4-day adult    1 Paraquat 5 mM 48 hrs, 4-day adult    1 Paraquat 10 mM 48 hrs, 4-day adult    1 Rotenone 2 μg 12 hrs, larvae L3    0 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    0 cold shock, 4-day adult    0 heat shock, 4-day adult    0 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    0 Cadmium 50 mM 48 hrs, 4-day adult    1 Cadmium 100 mM 48 hrs, 4-day adult    0 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    0 Zinc 5 mM 12 hrs, larvae L3    0 Zinc 4.5 mM 48 hrs, 4-day adult    1 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    0 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    1 Caffeine 25 mg/ml 48 hrs, 4-day adult    1 Paraquat 5 mM 48 hrs, 4-day adult    1 Paraquat 10 mM 48 hrs, 4-day adult    1 Rotenone 2 μg 12 hrs, larvae L3    0 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    0 cold shock, 4-day adult    0 heat shock, 4-day adult    0 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    0 Cadmium 50 mM 48 hrs, 4-day adult    1 Cadmium 100 mM 48 hrs, 4-day adult    0 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    0 Zinc 5 mM 12 hrs, larvae L3    0 Zinc 4.5 mM 48 hrs, 4-day adult    1 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    0 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    1 Caffeine 25 mg/ml 48 hrs, 4-day adult    1 Paraquat 5 mM 48 hrs, 4-day adult    1 Paraquat 10 mM 48 hrs, 4-day adult    1 Rotenone 2 μg 12 hrs, larvae L3    0 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    0 cold shock, 4-day adult    0 heat shock, 4-day adult    0 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    0 Cadmium 50 mM 48 hrs, 4-day adult    1 Cadmium 100 mM 48 hrs, 4-day adult    0 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    0 Zinc 5 mM 12 hrs, larvae L3    0 Zinc 4.5 mM 48 hrs, 4-day adult    1 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    0 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    1 Caffeine 25 mg/ml 48 hrs, 4-day adult    1 Paraquat 5 mM 48 hrs, 4-day adult    1 Paraquat 10 mM 48 hrs, 4-day adult    1 Rotenone 2 μg 12 hrs, larvae L3    0 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    0 cold shock, 4-day adult    0 heat shock, 4-day adult    0 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    0 Cadmium 50 mM 48 hrs, 4-day adult    1 Cadmium 100 mM 48 hrs, 4-day adult    0 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    0 Zinc 5 mM 12 hrs, larvae L3    0 Zinc 4.5 mM 48 hrs, 4-day adult    1 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    0 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    1 Caffeine 25 mg/ml 48 hrs, 4-day adult    1 Paraquat 5 mM 48 hrs, 4-day adult    1 Paraquat 10 mM 48 hrs, 4-day adult    1 Rotenone 2 μg 12 hrs, larvae L3    0 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    0 cold shock, 4-day adult    0 heat shock, 4-day adult    0 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    0 Cadmium 50 mM 48 hrs, 4-day adult    1 Cadmium 100 mM 48 hrs, 4-day adult    0 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    0 Zinc 5 mM 12 hrs, larvae L3    0 Zinc 4.5 mM 48 hrs, 4-day adult    1 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    0 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    1 Caffeine 25 mg/ml 48 hrs, 4-day adult    1 Paraquat 5 mM 48 hrs, 4-day adult    1 Paraquat 10 mM 48 hrs, 4-day adult    1 Rotenone 2 μg 12 hrs, larvae L3    0 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    0 cold shock, 4-day adult    0 heat shock, 4-day adult    0 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    0 Cadmium 50 mM 48 hrs, 4-day adult    1 Cadmium 100 mM 48 hrs, 4-day adult    0 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    0 Zinc 5 mM 12 hrs, larvae L3    0 Zinc 4.5 mM 48 hrs, 4-day adult    1 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    0 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    1 Caffeine 25 mg/ml 48 hrs, 4-day adult    1 Paraquat 5 mM 48 hrs, 4-day adult    1 Paraquat 10 mM 48 hrs, 4-day adult    1 Rotenone 2 μg 12 hrs, larvae L3    0 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    0 cold shock, 4-day adult    0 heat shock, 4-day adult    0 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    0 Cadmium 50 mM 48 hrs, 4-day adult    1 Cadmium 100 mM 48 hrs, 4-day adult    0 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    0 Zinc 5 mM 12 hrs, larvae L3    0 Zinc 4.5 mM 48 hrs, 4-day adult    1 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    0 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    1 Caffeine 25 mg/ml 48 hrs, 4-day adult    1 Paraquat 5 mM 48 hrs, 4-day adult    1 Paraquat 10 mM 48 hrs, 4-day adult    1 Rotenone 2 μg 12 hrs, larvae L3    0 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_15 mE1_20_mRNA_expression_cluster_13
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0037324 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG10609-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable, with Scer\GAL4pnr-MD237 OrcoGD666 Other Phenotypes Allele behavior defective | male Orco1 chemical resistant | conditional Orco1 chemical sensitive | conditional Orco1 chemosensitive behavior defective | adult stage Orco1 chemosensitive behavior defective | adult stage (with Orco1) Orco2 chemosensitive behavior defective | adult stage (with Orco2) Orco1 hyperactive | conditional Orco1 hypoactive | conditional Orco1 locomotor behavior defective Orco2 long lived | female Orco2 long lived | male Orco2 mating rhythm defective Orco1 neurophysiology defective (with Orco1) Orco2 neurophysiology defective (with Orco2) Orco1 neurophysiology defective | embryonic stage Orcounspecified neurophysiology defective | first instar larval stage Orcounspecified smell perception defective Orco1 Orco2 Orco3 OrcoZ0061 OrcoZ4506 smell perception defective, with Orco1, Scer\GAL4Or42a.PF OrcoScer\UAS.cLa smell perception defective, with Orco2/Orco1, Scer\GAL4Or42a.PF OrcoScer\UAS.cLa OrcoScer\UAS.T:Avic\GFP smell perception defective, with OrcoScer\UAS.cLa, Scer\GAL4Or42a.PF Orco1 smell perception defective (with Orco1) Orco2 smell perception defective (with Orco1), with OrcoScer\UAS.cLa, Scer\GAL4Or42a.PF Orco2 smell perception defective (with Orco1), with OrcoScer\UAS.T:Avic\GFP, Scer\GAL4Or42a.PF Orco2 smell perception defective (with Orco2) Orco1 smell perception defective (with Orco2), with OrcoScer\UAS.cLa, Scer\GAL4Or42a.PF Orco1 smell perception defective (with Orco2), with OrcoScer\UAS.T:Avic\GFP, Scer\GAL4Or42a.PF Orco1 smell perception defective | dominant | female Orco2 Phenotype manifest in Allele antennal sense organ Orco2 embryonic/larval olfactory receptor neuron Orcounspecified olfactory receptor neuron (with Orco1) Orco2 olfactory receptor neuron (with Orco2) Orco1
Classical Alleles ( 6 )
For All Classical Alleles Show
Allele of Orco Class Mutagen Stocks Known lesion Orco1 loss of function allele recombination FLPase SCEI endonuclease gene targeting by homologous recombination 1 Yes Orco2 loss of function allele recombination FLPase SCEI endonuclease gene targeting by homologous recombination 1 Yes Orco3 loss of function allele recombination FLPase SCEI endonuclease gene targeting by homologous recombination 0 Yes Orcounspecified 0 -- OrcoZ0061 0 Yes OrcoZ4506 0 Yes
Alleles Carried on Transgenic Constructs ( 21 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Orco Class Mutagen Stocks Known lesion OrcoGD666 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes OrcoJF01219 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes OrcoJF01220 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes OrcoKK103037 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes OrcoScer\UAS.cLa in vitro construct - regulatory fusion 1 Yes Orco+CH322-81L19 in vitro construct - genomic fragment 0 Yes OrcoEndsOut.L in vitro construct 0 Yes OrcoNterm.MtnA.T:Ecol\lacZ,T:Zzzz\TM in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes OrcoNterm.MtnA.T:Ecol\lacZ in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes OrcoNterm.TM1.MtnA.T:Ecol\lacZ,T:Zzzz\TM in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes OrcoNterm.TM1.MtnA.T:Ecol\lacZ in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes OrcoScer\FRT.Scer\UAS.T:Avic\GFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes OrcoScer\UAS.cBa in vitro construct - regulatory fusion 0 Yes OrcoScer\UAS.T:Avic\GFP-EGFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes OrcoScer\UAS.T:Avic\GFP-YFP(1) in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes OrcoScer\UAS.T:Avic\GFP-YFP(2) in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes OrcoScer\UAS.T:Avic\GFP FLPase 0 Yes OrcoScer\UAS.T:Hsap\MYC in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes OrcoScer\UAS.YFP(1).ZIP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes OrcoScer\UAS.YFP(2).ZIP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes OrcoT:Hsap\MYC in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3R)Exel9029 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data GAL4 construct P{Orco-GAL4.U} No UAS construct P{UAS(-FRT)GFP-Or83b} NA P{UAS(RFP-stop.FRT)GFP-Or83b} NA P{UAS-Orco.EGFP} NA characterization construct P{CH322-81L19} NA P{Orco-RFP.K} NA
Insertions
	Type of insertions Name Expression data
Gene Ontology: Function, Process & Cellular Component ( 11 unique terms )
Terms Based on Experimental Evidence ( 8 terms )
Molecular Function
CV term Evidence References
olfactory receptor activity inferred from direct assay (Benton et al., 2006) protein homodimerization activity inferred from physical interaction with Orco (Benton et al., 2006)
Biological Process
CV term Evidence References
behavioral response to ethanol inferred from mutant phenotype (Kong et al., 2010) olfactory behavior inferred from mutant phenotype (Larsson et al., 2004, Fishilevich et al., 2005) protein heterooligomerization inferred from physical interaction with Or43a (Benton et al., 2006) response to pheromone inferred from mutant phenotype (Jin et al., 2008)
Cellular Component
CV term Evidence References
dendrite inferred from direct assay (Benton et al., 2006) plasma membrane inferred from direct assay (Benton et al., 2006)
Terms Based on Predictions or Assertions ( 4 terms )
Molecular Function
CV term Evidence References
odorant binding inferred from electronic annotation with InterPro:IPR004117 (FlyBase Curators et al., 2004-) olfactory receptor activity inferred from sequence or structural similarity (Swiss-Prot Project Members, 2000.5.1) non-traceable author statement (FlyBase, 1992-)
Biological Process
CV term Evidence References
sensory perception of smell inferred from electronic annotation with InterPro:IPR004117 (FlyBase Curators et al., 2004-) inferred from sequence or structural similarity (Swiss-Prot Project Members, 2000.5.1) non-traceable author statement (Carlson, 2001) traceable author statement (Keller and Vosshall, 2003)
Cellular Component
CV term Evidence References
integral to membrane inferred from sequence or structural similarity (Swiss-Prot Project Members, 2000.5.1)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Orco allele Gene References
External Data
Linkouts	DroID - A comprehensive database of gene and protein interactions. • FBgn0037324 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 40650
Orthologs
OrthoDB Orthologs (32) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6QZ85N Dipteran inclusive ortholog search EOG62JP0S Insect inclusive ortholog search EOG6FQZN0 Arthropod inclusive ortholog search EOG68SF8D Metazoa inclusive ortholog search No orthologs identified
Orthologs in Drosophila Species (EOG6QZ85N)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\Orco     Drosophila simulans   Dsim\GD19619 Y   Drosophila sechellia   Dsec\GM10637 Y   Drosophila erecta   Dere\GG11032 Y   Drosophila yakuba   Dyak\GE25284 Y   Drosophila ananassae   Dana\GF16031     Drosophila ananassae   Dana\GF17712 Y   Drosophila ananassae   Dana\GF11984     Drosophila pseudoobscura pseudoobscura   Dpse\Orco Y   Drosophila persimilis   Dper\GL22168 Y   Drosophila willistoni   Dwil\GK22840 Y   Drosophila virilis   Dvir\GJ24719 Y   Drosophila mojavensis   Dmoj\GI23643 Y   Drosophila grimshawi   Dgri\GH22610 Y
Orthologs in non-Drosophila Dipterans (EOG62JP0S)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL005776   Anopheles gambiae Malaria mosquito  Agam\GPRor7   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ009573
Orthologs in non-Dipteran Insects (EOG6FQZN0)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB40730   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG037046   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH17013   Atta cephalotes Leafcutter ant  Acep\ACEP24215   Camponotus floridanus Florida carpenter ant  Cflo\CFLO15004   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL17155   Linepithema humile Argentine ant  Lhum\LH11309   Linepithema humile Argentine ant  Lhum\LH19204   Pogonomyrmex barbatus Red harvester ant  Pbar\PB15712   Solenopsis invicta Red fire ant  Sinv\SINV16611   Acyrthosiphon pisum Pea aphid  Apim\ACYPI006063   Bombyx mori Silkmoth  Bmor\BGIBMGA013012   Pediculus humanus Human body louse  Phum\PHUM213810   Tribolium castaneum Red flour beetle  Tcas\or16
Orthologs in non-Insect Arthropods (EOG68SF8D)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Ixodes scapularis Deer tick  Isca\ISCW800162
Orthologs in non-Arthropod Metazoa (None identified)
No non-Arthropod Metazoa orthologies identified
Human Orthologs (0)
Gene OMIM HGNC
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD19619 Drosophila sechellia Dsec\GM10637 Drosophila erecta Dere\GG11032 Drosophila yakuba Dyak\GE25284 Drosophila ananassae Dana\GF17712 Drosophila pseudoobscura pseudoobscura Dpse\Orco Drosophila persimilis Dper\GL22168 Drosophila willistoni Dwil\GK22840 Drosophila virilis Dvir\GJ24719 Drosophila mojavensis Dmoj\GI23643 Drosophila grimshawi Dgri\GH22610
Stocks & Reagents
Stocks Listed in FlyBase ( 7 )
Bloomington	23145 w*; P{UAS-Orco.L}13.20A 23129 w*; w+* Orco1 23130 w*; w+* Orco2 31278 y1 v1; P{TRiP.JF01219}attP2 31279 y1 v1; P{TRiP.JF01220}attP2
VDRC	v100825 P{KK103037}VIE-260B v13386 w1118; P{GD666}v13386
Genomic Clones ( 2 )
	BACR34M23 BACR42H10 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 11 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	IP03509
Other clones	IP03309
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones
Other clones	CK01.61C.F2 EC051245 EC051749 EC052345 EC054332 EC055839 EK048553 IP03209 IP03409
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0037324 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 40650
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: Or83b CG10609 (Warr and Vosshall, 2000.5.19) Source for identity of: Orco Or83b (Vosshall and Hansson, 2011.1.24)
Source for database merge of
Additional comments
Other Comments
	The Or83b product is required to maintain odorant receptor localization and stability. (Benton et al., 2006)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_079511 NM_001104217 RefSeq (Proteins) • NP_524235 NP_001097687 DDBJ / EMBL / GenBank • AAF52031 AAT71306 ABW08603 AY567998 DD163177 Entrez Gene - A searchable database of RefSeq genes. • 40650 UniProtKB/Swiss-Prot • Q9VNB5
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Olfactory receptor, Drosophila (IPR004117)
Linkouts
	DroID - A comprehensive database of gene and protein interactions. • FBgn0037324 DRSC - Results from RNAi screens. • FBgn0037324 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0037324 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG10609-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0037324 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 40650 Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /hjmuller/or83b-1.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 40650 modMine - Data generated by the modENCODE project. • FBgn0037324
Synonyms & Secondary IDs ( 19 )
Reported As
Symbol Synonym	83A.2 (Warr and Vosshall, 2000.5.19) 83b (Vogt et al., 2002) A45   CG10609 (Keleman et al., 2009.8.5, Robertson, 2009, Ni et al., 2009, Ni et al., 2008) DOR45 (Warr and Vosshall, 2000.5.19) DOR83b (Neuhaus et al., 2005) OR49 (Nozawa and Nei, 2007) OR83b (Benton et al., 2006, Stocker, 2006, Kalidas and Smith, 2002, Kalidas et al., 2001, Libert, 2007, Gross, 2006, Stocker, 2006, Lundin et al., 2007, Nozawa and Nei, 2007, Rhodenizer et al., 2008, Benton et al., 2009, Nichols and Luetje, 2010, Croset et al., 2010) or83b (Liu et al., 2007, Reis et al., 2010) Or83b (Deng et al., 2011, Franco et al., 2011, Niewalda et al., 2011, Miyazaki and Ito, 2010, Lone and Sharma, 2011, Immonen and Ritchie, 2012, Prieto-Godino et al., 2012, Foley et al., 2010, Kong et al., 2010, Mishra et al., 2010, Sambandan et al., 2008, Fujii et al., 2007, Lai and Lee, 2006, de Bruyne and Warr, 2006, Kreher et al., 2005, Lee et al., 2010, Bargmann, 2006, van der Goes van Naters and Carlson, 2006, Leslie, 2007, Libert et al., 2007, Benton et al., 2007, Grillenzoni et al., 2007, Jones et al., 2007, Poon et al., 2008, Benton et al., 2007, Louis et al., 2008, McBride et al., 2007, Ditzen et al., 2008, Huang et al., 2008, Wicher et al., 2008, Sato et al., 2008, Olsen and Wilson, 2008, Hiroi et al., 2008, Sachse et al., 2007, Jin et al., 2008, Krishnan et al., 2008, Asahina et al., 2008, DasGupta and Waddell, 2008, Hoare et al., 2008, Krstic et al., 2009, Sen et al., 2005, Chiang et al., 2009, Asahina et al., 2009, Smart et al., 2008, Guo and Kim, 2007, Ignell et al., 2009, Robertson, 2009, Kamikouchi et al., 2006, Wang and Anderson, 2010, Masuda-Nakagawa et al., 2009, Zhou et al., 2009, Morozova et al., 2006, Poon et al., 2010, Yao and Carlson, 2010, Bellmann et al., 2010, Olsen et al., 2007, Kazama et al., 2011, Larkin et al., 2010, Kwon et al., 2007, Bhandawat et al., 2010, Lone and Sharma, 2011, Lone and Sharma, 2012, Billeter et al., 2012) OR83B (Ni et al., 2009) Orco (Silbering et al., 2011, Schneider et al., 2012, Gomez-Marin et al., 2011, Hoare et al., 2011, Niewalda et al., 2011, Nichols et al., 2011, Wisotsky et al., 2011, Prieto-Godino et al., 2012, Vosshall and Hansson, 2011.1.24, Vosshall and Hansson, 2011, Montague et al., 2011, Trott et al., 2012, Schneider et al., 2012, Billeter et al., 2012, Wang et al., 2011) vainsA (Jin et al., 2008)
Name Synonym	odorant receptor 83b (Gross, 2006) Odorant receptor 83b   Odorant receptor co-receptor   olfactory co-receptor (Kong et al., 2010) Olfactory coreceptor (Kong et al., 2010) olfactory receptor co-receptor (Vosshall and Hansson, 2011)
Secondary FlyBase IDs
References ( 150 )
Generate a list of	All references relating to this gene ( 150 )
List References by type	Research paper  ( 113 ) Supplementary material  ( 5 ) Review  ( 13 ) Personal communication to FlyBase  ( 7 ) Abstract  ( 4 ) FlyBase analysis  ( 1 ) Conference report  ( 1 ) Letter  ( 2 ) Protein sequence record  ( 1 ) Curated genome annotation  ( 2 ) DNA/RNA sequence record  ( 1 )
Recent research papers ( 33 )
	Gaudry et al., 2013, Nature 493(7432): 424--428 Asymmetric neurotransmitter release enables rapid odour lateralization in Drosophila. [FBrf0220588] German et al., 2013, Insect Biochem. Mol. Biol. 43(2): 138--145 Insights into subunit interactions within the insect olfactory receptor complex using FRET. [FBrf0220621] Billeter et al., 2012, Proc. Biol. Sci. 279(1737): 2417--2425 Drosophila melanogaster females change mating behaviour and offspring production based on social context. [FBrf0218319] Chen et al., 2012, Science 335(6069): 678--685 Visualizing long-term memory formation in two neurons of the Drosophila brain. [FBrf0217453] Getahun et al., 2012, Front. Cell. Neurosci. 6: 54 Temporal response dynamics of Drosophila olfactory sensory neurons depends on receptor type and response polarity. [FBrf0220010] Immonen and Ritchie, 2012, Proc. Biol. Sci. 279(1732): 1359--1365 The genomic response to courtship song stimulation in female Drosophila melanogaster. [FBrf0217554] Kim et al., 2012, Nat. Neurosci. 15(6): 876--883 Contribution of visual and circadian neural circuits to memory for prolonged mating induced by rivals. [FBrf0219349] Lone and Sharma, 2012, J. Biol. Rhythms 27(2): 107--116 Or47b Receptor Neurons Mediate Sociosexual Interactions in the Fruit Fly Drosophila melanogaster. [FBrf0218005] Montagné et al., 2012, Europ. J. Neurosci. 36(5): 2588--2596 Functional characterization of a sex pheromone receptor in the pest moth Spodoptera littoralis by heterologous expression in Drosophila. [FBrf0219324] Prieto-Godino et al., 2012, PLoS Biol. 10(10): e1001400 Embryonic origin of olfactory circuitry in Drosophila: contact and activity-mediated interactions pattern connectivity in the antennal lobe. [FBrf0219665] Schneider et al., 2012, PLoS ONE 7(12): e52007 Neuronal basis of innate olfactory attraction to ethanol in Drosophila. [FBrf0220349] Schneider et al., 2012, Proc. Natl. Acad. Sci. U.S.A. 109 Suppl 2: 17174--17179 Social structures depend on innate determinants and chemosensory processing in Drosophila. [FBrf0219728] Simon et al., 2012, Genes Brain Behav. 11(2): 243--252 A simple assay to study social behavior in Drosophila: measurement of social space within a group(1). [FBrf0217332] Steck et al., 2012, Sci. Rep. 2: 361 A high-throughput behavioral paradigm for Drosophila olfaction - The Flywalk. [FBrf0218068] Trott et al., 2012, PLoS ONE 7(9): e46025 Song choice is modulated by female movement in Drosophila males. [FBrf0219637] Bretman et al., 2011, Curr. Biol. 21(7): 617--622 Males use multiple, redundant cues to detect mating rivals. [FBrf0213421] Deng et al., 2011, PLoS ONE 6(4): e18605 The Stimulatory Gα(s) Protein Is Involved in Olfactory Signal Transduction in Drosophila. [FBrf0213437] Franco et al., 2011, Proc. Natl. Acad. Sci. U.S.A. 108(9): 3797--3802 Molecular vibration-sensing component in Drosophila melanogaster olfaction. [FBrf0213196] Galili et al., 2011, J. Neurosci. 31(20): 7240--7248 Olfactory trace conditioning in Drosophila. [FBrf0213816] Gomez-Marin et al., 2011, Nat. Commun. 2: 441 Active sampling and decision making in Drosophila chemotaxis. [FBrf0214803] Hoare et al., 2011, PLoS ONE 6(8): e22996 Modeling peripheral olfactory coding in Drosophila larvae. [FBrf0214697] Kazama et al., 2011, J. Neurosci. 31(21): 7619--7630 Cell Death Triggers Olfactory Circuit Plasticity via Glial Signaling in Drosophila. [FBrf0213815] Lone and Sharma, 2011, J. Exp. Biol. 214(22): 3742--3750 Social synchronization of circadian locomotor activity rhythm in the fruit fly Drosophila melanogaster. [FBrf0216518] Lone and Sharma, 2011, PLoS ONE 6(12): e28336 Circadian Consequence of Socio-Sexual Interactions in Fruit Flies Drosophila melanogaster. [FBrf0217074] Montague et al., 2011, J. Neurosci. 31(21): 7891--7899 Similar odorants elicit different behavioral and physiological responses, some supersustained. [FBrf0213787] Nichols et al., 2011, Chem. Senses 36(9): 781--790 Subunit contributions to insect olfactory receptor function: channel block and odorant recognition. [FBrf0216371] Niewalda et al., 2011, PLoS ONE 6(9): e24300 A combined perceptual, physico-chemical, and imaging approach to 'odour-distances' suggests a categorizing function of the Drosophila antennal lobe. [FBrf0215586] Pellegrino et al., 2011, Nature 478(7370): 511--514 A natural polymorphism alters odour and DEET sensitivity in an insect odorant receptor. [FBrf0216484] Root et al., 2011, Cell 145(1): 133--144 Presynaptic facilitation by neuropeptide signaling mediates odor-driven food search. [FBrf0213351] Sargsyan et al., 2011, Front. Cell. Neurosci. 5: 5 Phosphorylation via PKC Regulates the Function of the Drosophila Odorant Co-Receptor. [FBrf0214040] Silbering et al., 2011, J. Neurosci. 31(38): 13357--13375 Complementary Function and Integrated Wiring of the Evolutionarily Distinct Drosophila Olfactory Subsystems. [FBrf0215822] Wang et al., 2011, PLoS ONE 6(11): e25890 Drosophila TRPA Channel Painless Inhibits Male-Male Courtship Behavior through Modulating Olfactory Sensation. [FBrf0216587] Wisotsky et al., 2011, Nat. Neurosci. 14(12): 1534--1541 Evolutionary differences in food preference rely on Gr64e, a receptor for glycerol. [FBrf0216771] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...