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Gene Dmel\PEK

General Information
Symbol	Dmel\PEK	Species	D. melanogaster
Name	pancreatic eIF-2α kinase	Annotation symbol	CG2087
Feature type	protein_coding_gene	FlyBase ID	FBgn0037327
Gene Model Status	Current	Stock availability	7 publicly available
Also Known As	Perk, DPERK, EIF2-like
Genomic Location
Chromosome (arm)	3R	Recombination map
Cytogenetic map	83A4-83A4	Sequence location	3R:1,284,285..1,290,475 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene pancreatic eIF-2α kinase is referred to in FlyBase by the symbol Dmel\PEK (CG2087, FBgn0037327). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: elongation factor-2 kinase activity. There is experimental evidence that it is involved in the biological process: regulation of G2/M transition of mitotic cell cycle. 18 alleles are reported. The phenotypes of these alleles are annotated with: eye disc; eye disc posterior to the morphogenetic furrow. It has 3 annotated transcripts and 3 annotated polypeptides. Protein features are: Protein kinase, ATP binding site; Protein kinase, catalytic domain; Protein kinase-like domain; Pyrrolo-quinoline quinone beta-propeller repeat; Quinonprotein alcohol dehydrogenase-like-superfamily; Serine/threonine-protein kinase, active site. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-06 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult tissues/organs expressed at moderate levels. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male accessory gland, larval carcass. Comments on Affy2 ProbeSet: ProbeSet 1641072_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of PEK. Gene sequence location is 3R:1284285..1290475.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 83A4-83A4   Limits computationally determined from genome sequence between P{EP}EP974 and P{PZ}Snr101319&P{PZ}Itp-r83A05616
Experimentally Determined Cytological Location
Cytogenetic map Notes References 83A1-83A3     (Cavener et al., 2000.3.10)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\PEK for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.44 Gene model reviewed during 5.47 Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated Annotated transcripts do not represent all supported alternative splices within 5' UTR. Low-frequency RNA-Seq exon junction(s) not annotated.
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) PEK-RA FBtr0078770  NM_141281   4639   1162 PEK-RB FBtr0330026  NM_001275353   4265   1110 PEK-RC FBtr0330027  NM_001275354   4169   1099
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein PEK-PA   FBpp0078417   131.0   1162   4.70     NP_649538   AAF52028 PEK-PB   FBpp0303059   125.5   1110   4.71     NP_001262282   AGB95665 PEK-PC   FBpp0303060   124.1   1099   4.67     NP_001262283   AGB95666
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Pyrrolo-quinoline quinone beta-propeller repeat (IPR018391) Protein kinase, catalytic domain (IPR000719) Serine/threonine-protein kinase, active site (IPR008271) Protein kinase-like domain (IPR011009) Quinonprotein alcohol dehydrogenase-like superfamily (IPR011047) Protein kinase, ATP binding site (IPR017441) Quinonprotein alcohol dehydrogenase-like domain (IPR027295)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA201301   AA202355   AA263388   AA390738   AA439151   AA439740   AA540253   AA820263   AA941788   AA942423   AA948919   AE014297 AAF52028   AF193340 AAF61200   AE014297 AGB95665   AE014297 AGB95666   AI294535   AI456071   AI515860   AI515986   AI516127   AI531536   AI531811   AI532420   AI533893   AI542275   AI542281   AJ313085 CAC85207   AW943572   AY094831 AAM11184   BF486645   BF488930   BG635692   BI163767   BI214000   BI214714   BI233178   BI234099   BI364652   BI375628   BI604651   BI637704   CL526124   CO180719   CO187057   CO196557   CO264453   CO281546   CO282729   CO294956   CO296133   CO299692   CO301725   CO304391   CO313533   CZ479556   EC051516   EC052016   EC053540   EC056832   EC057499   EC064104   EC074270   EC199455   EC199627   EC199744   EC202734   EC202735   EC209795   EC210295   EC221439   GH790000   GH806577   GH838102   GH846662   GH847002   GH847710   GH852899   GH854696   GH864272   GH876083   GH883486   GH919289   GH921067   GH921842   GH940167
UniProtKB/Swiss-Prot	Q9NIV1
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 3   organism   (Fisher et al., 2012) Comment:maternally deposited embryonic stage 4 -- 6   organism   (Fisher et al., 2012) Comment:rapidly degraded organism | ubiquitous   • cytoplasm | basal (Fisher et al., 2012) Comment:apically cleared embryonic stage 11 -- 12   visceral muscle primordium   (Fisher et al., 2012) embryonic stage 13 -- 16   embryonic/larval muscle system   (Fisher et al., 2012) embryonic/larval somatic muscle   (Fisher et al., 2012) embryonic/larval visceral muscle   (Fisher et al., 2012)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult tissues/organs expressed at moderate levels. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male accessory gland, larval carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    352.875 Larval Midgut    269.4 Larval Hindgut    241.6 Larval Malpighian Tubules    211.6 Larval Fat Body    78.7 Larval Salivary Gland    275.5 Larval Trachea    217.525 Larval Carcass    208.8 Adult Head    111.4 Adult Eye    148.825 Adult Brain    178.2 Adult Thoracic-Abdominal Ganglion    254.3 Adult Crop    189.7 Adult Midgut    170.7 Adult Hindgut    144.8 Adult Malpighian Tubules    233 Adult Fat Body    150.4 Adult Salivary Gland    175.8 Adult Heart    115.95 Adult VirginFemale Spermatheca    188.1 Adult InseminatedFemale Spermatheca    201.8 Adult Ovary    436.3 Adult Testis    33.9 Adult Male Accessory Gland    185.6 Adult Carcass    88.4 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    352.875 Larval Midgut    269.4 Larval Hindgut    241.6 Larval Malpighian Tubules    211.6 Larval Fat Body    78.7 Larval Salivary Gland    275.5 Larval Trachea    217.525 Larval Carcass    208.8 Adult Head    111.4 Adult Eye    148.825 Adult Brain    178.2 Adult Thoracic-Abdominal Ganglion    254.3 Adult Crop    189.7 Adult Midgut    170.7 Adult Hindgut    144.8 Adult Malpighian Tubules    233 Adult Fat Body    150.4 Adult Salivary Gland    175.8 Adult Heart    115.95 Adult VirginFemale Spermatheca    188.1 Adult InseminatedFemale Spermatheca    201.8 Adult Ovary    436.3 Adult Testis    33.9 Adult Male Accessory Gland    185.6 Adult Carcass    88.4 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    352.875 Larval Midgut    269.4 Larval Hindgut    241.6 Larval Malpighian Tubules    211.6 Larval Fat Body    78.7 Larval Salivary Gland    275.5 Larval Trachea    217.525 Larval Carcass    208.8 Adult Head    111.4 Adult Eye    148.825 Adult Brain    178.2 Adult Thoracic-Abdominal Ganglion    254.3 Adult Crop    189.7 Adult Midgut    170.7 Adult Hindgut    144.8 Adult Malpighian Tubules    233 Adult Fat Body    150.4 Adult Salivary Gland    175.8 Adult Heart    115.95 Adult VirginFemale Spermatheca    188.1 Adult InseminatedFemale Spermatheca    201.8 Adult Ovary    436.3 Adult Testis    33.9 Adult Male Accessory Gland    185.6 Adult Carcass    88.4 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    352.875 Larval Midgut    269.4 Larval Hindgut    241.6 Larval Malpighian Tubules    211.6 Larval Fat Body    78.7 Larval Salivary Gland    275.5 Larval Trachea    217.525 Larval Carcass    208.8 Adult Head    111.4 Adult Eye    148.825 Adult Brain    178.2 Adult Thoracic-Abdominal Ganglion    254.3 Adult Crop    189.7 Adult Midgut    170.7 Adult Hindgut    144.8 Adult Malpighian Tubules    233 Adult Fat Body    150.4 Adult Salivary Gland    175.8 Adult Heart    115.95 Adult VirginFemale Spermatheca    188.1 Adult InseminatedFemale Spermatheca    201.8 Adult Ovary    436.3 Adult Testis    33.9 Adult Male Accessory Gland    185.6 Adult Carcass    88.4 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    352.875 Larval Midgut    269.4 Larval Hindgut    241.6 Larval Malpighian Tubules    211.6 Larval Fat Body    78.7 Larval Salivary Gland    275.5 Larval Trachea    217.525 Larval Carcass    208.8 Adult Head    111.4 Adult Eye    148.825 Adult Brain    178.2 Adult Thoracic-Abdominal Ganglion    254.3 Adult Crop    189.7 Adult Midgut    170.7 Adult Hindgut    144.8 Adult Malpighian Tubules    233 Adult Fat Body    150.4 Adult Salivary Gland    175.8 Adult Heart    115.95 Adult VirginFemale Spermatheca    188.1 Adult InseminatedFemale Spermatheca    201.8 Adult Ovary    436.3 Adult Testis    33.9 Adult Male Accessory Gland    185.6 Adult Carcass    88.4 Expression Level Scale  None   Low   Moderate   High  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    352.875 Larval Midgut    269.4 Larval Hindgut    241.6 Larval Malpighian Tubules    211.6 Larval Fat Body    78.7 Larval Salivary Gland    275.5 Larval Trachea    217.525 Larval Carcass    208.8 Adult Head    111.4 Adult Eye    148.825 Adult Brain    178.2 Adult Thoracic-Abdominal Ganglion    254.3 Adult Crop    189.7 Adult Midgut    170.7 Adult Hindgut    144.8 Adult Malpighian Tubules    233 Adult Fat Body    150.4 Adult Salivary Gland    175.8 Adult Heart    115.95 Adult VirginFemale Spermatheca    188.1 Adult InseminatedFemale Spermatheca    201.8 Adult Ovary    436.3 Adult Testis    33.9 Adult Male Accessory Gland    185.6 Adult Carcass    88.4 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    352.875 Larval Midgut    269.4 Larval Hindgut    241.6 Larval Malpighian Tubules    211.6 Larval Fat Body    78.7 Larval Salivary Gland    275.5 Larval Trachea    217.525 Larval Carcass    208.8 Adult Head    111.4 Adult Eye    148.825 Adult Brain    178.2 Adult Thoracic-Abdominal Ganglion    254.3 Adult Crop    189.7 Adult Midgut    170.7 Adult Hindgut    144.8 Adult Malpighian Tubules    233 Adult Fat Body    150.4 Adult Salivary Gland    175.8 Adult Heart    115.95 Adult VirginFemale Spermatheca    188.1 Adult InseminatedFemale Spermatheca    201.8 Adult Ovary    436.3 Adult Testis    33.9 Adult Male Accessory Gland    185.6 Adult Carcass    88.4 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    352.875 Larval Midgut    269.4 Larval Hindgut    241.6 Larval Malpighian Tubules    211.6 Larval Fat Body    78.7 Larval Salivary Gland    275.5 Larval Trachea    217.525 Larval Carcass    208.8 Adult Head    111.4 Adult Eye    148.825 Adult Brain    178.2 Adult Thoracic-Abdominal Ganglion    254.3 Adult Crop    189.7 Adult Midgut    170.7 Adult Hindgut    144.8 Adult Malpighian Tubules    233 Adult Fat Body    150.4 Adult Salivary Gland    175.8 Adult Heart    115.95 Adult VirginFemale Spermatheca    188.1 Adult InseminatedFemale Spermatheca    201.8 Adult Ovary    436.3 Adult Testis    33.9 Adult Male Accessory Gland    185.6 Adult Carcass    88.4 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    111.4   NA  Eye    148.825   NA  Brain    178.2   352.875  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    254.3   NA  Crop    189.7   269.4  Midgut    170.7   241.6  Hindgut    144.8   211.6  Malpighian Tubules    233   78.7  Fat Body    150.4   275.5  Salivary Gland    175.8   NA  Heart    115.95   217.525  Trachea    NA   NA  VirginFemale Spermatheca    188.1   NA  InseminatedFemale Spermatheca    201.8   NA  Ovary    436.3   NA  Testis    33.9   NA  Male Accessory Gland    185.6   208.8  Carcass    88.4 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    20 central nervous system, larvae L3    10 central nervous system, pupae P8    8 head, virgin 1-day female    7 head, virgin 4-day female    6 head, virgin 20-day female    8 head, mated 1-day female    5 head, mated 4-day female    7 head, mated 20-day female    6 head, mated 1-day male    8 head, mated 4-day male    10 head, mated 20-day male    12 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    9 digestive system, larvae L3 wandering    8 digestive system, 1-day adult    8 digestive system, 4-day adult    10 digestive system, 20-day adult    11 fat body, larvae L3 wandering    4 fat body, white prepupae    5 fat body, pupae P8    4 carcass, larvae L3 wandering    13 carcass, 1-day adult    5 carcass, 4-day adult    6 carcass, 20-day adult    6 ovary, virgin 4-day female    53 ovary, mated 4-day female    45 testis, mated 4-day male    6 accessory gland, mated 4-day male    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    20 central nervous system, larvae L3    10 central nervous system, pupae P8    8 head, virgin 1-day female    7 head, virgin 4-day female    6 head, virgin 20-day female    8 head, mated 1-day female    5 head, mated 4-day female    7 head, mated 20-day female    6 head, mated 1-day male    8 head, mated 4-day male    10 head, mated 20-day male    12 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    9 digestive system, larvae L3 wandering    8 digestive system, 1-day adult    8 digestive system, 4-day adult    10 digestive system, 20-day adult    11 fat body, larvae L3 wandering    4 fat body, white prepupae    5 fat body, pupae P8    4 carcass, larvae L3 wandering    13 carcass, 1-day adult    5 carcass, 4-day adult    6 carcass, 20-day adult    6 ovary, virgin 4-day female  (53) ovary, mated 4-day female  (45) testis, mated 4-day male    6 accessory gland, mated 4-day male    3 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    20 central nervous system, larvae L3    10 central nervous system, pupae P8    8 head, virgin 1-day female    7 head, virgin 4-day female    6 head, virgin 20-day female    8 head, mated 1-day female    5 head, mated 4-day female    7 head, mated 20-day female    6 head, mated 1-day male    8 head, mated 4-day male    10 head, mated 20-day male    12 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    9 digestive system, larvae L3 wandering    8 digestive system, 1-day adult    8 digestive system, 4-day adult    10 digestive system, 20-day adult    11 fat body, larvae L3 wandering    4 fat body, white prepupae    5 fat body, pupae P8    4 carcass, larvae L3 wandering    13 carcass, 1-day adult    5 carcass, 4-day adult    6 carcass, 20-day adult    6 ovary, virgin 4-day female    53 ovary, mated 4-day female    45 testis, mated 4-day male    6 accessory gland, mated 4-day male    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    20 central nervous system, larvae L3    10 central nervous system, pupae P8    8 head, virgin 1-day female    7 head, virgin 4-day female    6 head, virgin 20-day female    8 head, mated 1-day female    5 head, mated 4-day female    7 head, mated 20-day female    6 head, mated 1-day male    8 head, mated 4-day male    10 head, mated 20-day male    12 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    9 digestive system, larvae L3 wandering    8 digestive system, 1-day adult    8 digestive system, 4-day adult    10 digestive system, 20-day adult    11 fat body, larvae L3 wandering    4 fat body, white prepupae    5 fat body, pupae P8    4 carcass, larvae L3 wandering    13 carcass, 1-day adult    5 carcass, 4-day adult    6 carcass, 20-day adult    6 ovary, virgin 4-day female    53 ovary, mated 4-day female    45 testis, mated 4-day male    6 accessory gland, mated 4-day male    3 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    20 central nervous system, larvae L3    10 central nervous system, pupae P8    8 head, virgin 1-day female    7 head, virgin 4-day female    6 head, virgin 20-day female    8 head, mated 1-day female    5 head, mated 4-day female    7 head, mated 20-day female    6 head, mated 1-day male    8 head, mated 4-day male    10 head, mated 20-day male    12 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    9 digestive system, larvae L3 wandering    8 digestive system, 1-day adult    8 digestive system, 4-day adult    10 digestive system, 20-day adult    11 fat body, larvae L3 wandering    4 fat body, white prepupae    5 fat body, pupae P8    4 carcass, larvae L3 wandering    13 carcass, 1-day adult    5 carcass, 4-day adult    6 carcass, 20-day adult    6 ovary, virgin 4-day female    53 ovary, mated 4-day female    45 testis, mated 4-day male    6 accessory gland, mated 4-day male    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    20 central nervous system, larvae L3    10 central nervous system, pupae P8    8 head, virgin 1-day female    7 head, virgin 4-day female    6 head, virgin 20-day female    8 head, mated 1-day female    5 head, mated 4-day female    7 head, mated 20-day female    6 head, mated 1-day male    8 head, mated 4-day male    10 head, mated 20-day male    12 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    9 digestive system, larvae L3 wandering    8 digestive system, 1-day adult    8 digestive system, 4-day adult    10 digestive system, 20-day adult    11 fat body, larvae L3 wandering    4 fat body, white prepupae    5 fat body, pupae P8    4 carcass, larvae L3 wandering    13 carcass, 1-day adult    5 carcass, 4-day adult    6 carcass, 20-day adult    6 ovary, virgin 4-day female  (53) ovary, mated 4-day female  (45) testis, mated 4-day male    6 accessory gland, mated 4-day male    3 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    20 central nervous system, larvae L3    10 central nervous system, pupae P8    8 head, virgin 1-day female    7 head, virgin 4-day female    6 head, virgin 20-day female    8 head, mated 1-day female    5 head, mated 4-day female    7 head, mated 20-day female    6 head, mated 1-day male    8 head, mated 4-day male    10 head, mated 20-day male    12 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    9 digestive system, larvae L3 wandering    8 digestive system, 1-day adult    8 digestive system, 4-day adult    10 digestive system, 20-day adult    11 fat body, larvae L3 wandering    4 fat body, white prepupae    5 fat body, pupae P8    4 carcass, larvae L3 wandering    13 carcass, 1-day adult    5 carcass, 4-day adult    6 carcass, 20-day adult    6 ovary, virgin 4-day female    53 ovary, mated 4-day female    45 testis, mated 4-day male    6 accessory gland, mated 4-day male    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    20 central nervous system, larvae L3    10 central nervous system, pupae P8    8 head, virgin 1-day female    7 head, virgin 4-day female    6 head, virgin 20-day female    8 head, mated 1-day female    5 head, mated 4-day female    7 head, mated 20-day female    6 head, mated 1-day male    8 head, mated 4-day male    10 head, mated 20-day male    12 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    9 digestive system, larvae L3 wandering    8 digestive system, 1-day adult    8 digestive system, 4-day adult    10 digestive system, 20-day adult    11 fat body, larvae L3 wandering    4 fat body, white prepupae    5 fat body, pupae P8    4 carcass, larvae L3 wandering    13 carcass, 1-day adult    5 carcass, 4-day adult    6 carcass, 20-day adult    6 ovary, virgin 4-day female    53 ovary, mated 4-day female    45 testis, mated 4-day male    6 accessory gland, mated 4-day male    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-06 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    71 embryo 02-04hr    76 embryo 04-06hr    26 embryo 06-08hr    27 embryo 08-10hr    33 embryo 10-12hr    22 embryo 12-14hr    25 embryo 14-16hr    30 embryo 16-18hr    25 embryo 18-20hr    17 embryo 20-22hr    36 embryo 22-24hr    31 larva L1    14 larva L2    12 larva L3 12hr old    10 larva L3 puffstage 1-2    10 larva L3 puffstage 3-6    13 larva L3 puffstage 7-9    15 white prepupae new    15 white prepupae 12hr    15 white prepupae 24hr    16 pupae 2d postWPP    13 pupae 3d postWPP    9 pupae 4d postWPP    15 adult male 01day    11 adult male 05day    12 adult male 30day    13 adult female 01day    23 adult female 05day    37 adult female 30day    40 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (71) embryo 02-04hr  (76) embryo 04-06hr  26 embryo 06-08hr  (27) embryo 08-10hr  (33) embryo 10-12hr    22 embryo 12-14hr    25 embryo 14-16hr  (30) embryo 16-18hr    25 embryo 18-20hr    17 embryo 20-22hr  (36) embryo 22-24hr  (31) larva L1    14 larva L2    12 larva L3 12hr old    10 larva L3 puffstage 1-2    10 larva L3 puffstage 3-6    13 larva L3 puffstage 7-9    15 white prepupae new    15 white prepupae 12hr    15 white prepupae 24hr    16 pupae 2d postWPP    13 pupae 3d postWPP    9 pupae 4d postWPP    15 adult male 01day    11 adult male 05day    12 adult male 30day    13 adult female 01day    23 adult female 05day  (37) adult female 30day  (40) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    71 embryo 02-04hr    76 embryo 04-06hr    26 embryo 06-08hr    27 embryo 08-10hr    33 embryo 10-12hr    22 embryo 12-14hr    25 embryo 14-16hr    30 embryo 16-18hr    25 embryo 18-20hr    17 embryo 20-22hr    36 embryo 22-24hr    31 larva L1    14 larva L2    12 larva L3 12hr old    10 larva L3 puffstage 1-2    10 larva L3 puffstage 3-6    13 larva L3 puffstage 7-9    15 white prepupae new    15 white prepupae 12hr    15 white prepupae 24hr    16 pupae 2d postWPP    13 pupae 3d postWPP    9 pupae 4d postWPP    15 adult male 01day    11 adult male 05day    12 adult male 30day    13 adult female 01day    23 adult female 05day    37 adult female 30day    40 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    71 embryo 02-04hr    76 embryo 04-06hr    26 embryo 06-08hr    27 embryo 08-10hr    33 embryo 10-12hr    22 embryo 12-14hr    25 embryo 14-16hr    30 embryo 16-18hr    25 embryo 18-20hr    17 embryo 20-22hr    36 embryo 22-24hr    31 larva L1    14 larva L2    12 larva L3 12hr old    10 larva L3 puffstage 1-2    10 larva L3 puffstage 3-6    13 larva L3 puffstage 7-9    15 white prepupae new    15 white prepupae 12hr    15 white prepupae 24hr    16 pupae 2d postWPP    13 pupae 3d postWPP    9 pupae 4d postWPP    15 adult male 01day    11 adult male 05day    12 adult male 30day    13 adult female 01day    23 adult female 05day    37 adult female 30day    40 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    71 embryo 02-04hr    76 embryo 04-06hr    26 embryo 06-08hr    27 embryo 08-10hr    33 embryo 10-12hr    22 embryo 12-14hr    25 embryo 14-16hr    30 embryo 16-18hr    25 embryo 18-20hr    17 embryo 20-22hr    36 embryo 22-24hr    31 larva L1    14 larva L2    12 larva L3 12hr old    10 larva L3 puffstage 1-2    10 larva L3 puffstage 3-6    13 larva L3 puffstage 7-9    15 white prepupae new    15 white prepupae 12hr    15 white prepupae 24hr    16 pupae 2d postWPP    13 pupae 3d postWPP    9 pupae 4d postWPP    15 adult male 01day    11 adult male 05day    12 adult male 30day    13 adult female 01day    23 adult female 05day    37 adult female 30day    40 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (71) embryo 02-04hr  (76) embryo 04-06hr  26 embryo 06-08hr  27 embryo 08-10hr  (33) embryo 10-12hr    22 embryo 12-14hr    25 embryo 14-16hr  30 embryo 16-18hr    25 embryo 18-20hr    17 embryo 20-22hr  (36) embryo 22-24hr  31 larva L1    14 larva L2    12 larva L3 12hr old    10 larva L3 puffstage 1-2    10 larva L3 puffstage 3-6    13 larva L3 puffstage 7-9    15 white prepupae new    15 white prepupae 12hr    15 white prepupae 24hr    16 pupae 2d postWPP    13 pupae 3d postWPP    9 pupae 4d postWPP    15 adult male 01day    11 adult male 05day    12 adult male 30day    13 adult female 01day    23 adult female 05day  (37) adult female 30day  (40) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    71 embryo 02-04hr    76 embryo 04-06hr    26 embryo 06-08hr    27 embryo 08-10hr    33 embryo 10-12hr    22 embryo 12-14hr    25 embryo 14-16hr    30 embryo 16-18hr    25 embryo 18-20hr    17 embryo 20-22hr    36 embryo 22-24hr    31 larva L1    14 larva L2    12 larva L3 12hr old    10 larva L3 puffstage 1-2    10 larva L3 puffstage 3-6    13 larva L3 puffstage 7-9    15 white prepupae new    15 white prepupae 12hr    15 white prepupae 24hr    16 pupae 2d postWPP    13 pupae 3d postWPP    9 pupae 4d postWPP    15 adult male 01day    11 adult male 05day    12 adult male 30day    13 adult female 01day    23 adult female 05day    37 adult female 30day    40 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    71 embryo 02-04hr    76 embryo 04-06hr    26 embryo 06-08hr    27 embryo 08-10hr    33 embryo 10-12hr    22 embryo 12-14hr    25 embryo 14-16hr    30 embryo 16-18hr    25 embryo 18-20hr    17 embryo 20-22hr    36 embryo 22-24hr    31 larva L1    14 larva L2    12 larva L3 12hr old    10 larva L3 puffstage 1-2    10 larva L3 puffstage 3-6    13 larva L3 puffstage 7-9    15 white prepupae new    15 white prepupae 12hr    15 white prepupae 24hr    16 pupae 2d postWPP    13 pupae 3d postWPP    9 pupae 4d postWPP    15 adult male 01day    11 adult male 05day    12 adult male 30day    13 adult female 01day    23 adult female 05day    37 adult female 30day    40 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    39 Schneider line 2 Sg4    16 embryonic 1182-4H    43 embryonic GM2    53 embryonic Kc167    43 embryonic S1    36 embryonic S3    24 leg disc CME L1    22 wing disc CME-W2    27 wing disc ML-DmD8    20 wing disc ML-DmD9    26 wing disc ML-DmD16-c3    23 wing disc ML-DmD21    9 wing disc ML-DmD32    21 haltere disc ML-DmD17-c3    27 eye-antennal disc ML-DmD11    23 antennal disc ML-DmD20-c5    12 mixed discs ML-DmD4-c1    22 CNS ML-DmBG1-c1    25 CNS ML-DmBG2-c2    33 tumorous blood cells mbn2    43 ovary fGS/OSS    25 ovary OSC    27 ovary OSS    15 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (39) Schneider line 2 Sg4    16 embryonic 1182-4H  (43) embryonic GM2  (53) embryonic Kc167  (43) embryonic S1  (36) embryonic S3    24 leg disc CME L1    22 wing disc CME-W2  (27) wing disc ML-DmD8    20 wing disc ML-DmD9  26 wing disc ML-DmD16-c3    23 wing disc ML-DmD21    9 wing disc ML-DmD32    21 haltere disc ML-DmD17-c3  (27) eye-antennal disc ML-DmD11    23 antennal disc ML-DmD20-c5    12 mixed discs ML-DmD4-c1    22 CNS ML-DmBG1-c1    25 CNS ML-DmBG2-c2  (33) tumorous blood cells mbn2  (43) ovary fGS/OSS    25 ovary OSC  (27) ovary OSS    15 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    39 Schneider line 2 Sg4    16 embryonic 1182-4H    43 embryonic GM2    53 embryonic Kc167    43 embryonic S1    36 embryonic S3    24 leg disc CME L1    22 wing disc CME-W2    27 wing disc ML-DmD8    20 wing disc ML-DmD9    26 wing disc ML-DmD16-c3    23 wing disc ML-DmD21    9 wing disc ML-DmD32    21 haltere disc ML-DmD17-c3    27 eye-antennal disc ML-DmD11    23 antennal disc ML-DmD20-c5    12 mixed discs ML-DmD4-c1    22 CNS ML-DmBG1-c1    25 CNS ML-DmBG2-c2    33 tumorous blood cells mbn2    43 ovary fGS/OSS    25 ovary OSC    27 ovary OSS    15 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    39 Schneider line 2 Sg4    16 embryonic 1182-4H    43 embryonic GM2    53 embryonic Kc167    43 embryonic S1    36 embryonic S3    24 leg disc CME L1    22 wing disc CME-W2    27 wing disc ML-DmD8    20 wing disc ML-DmD9    26 wing disc ML-DmD16-c3    23 wing disc ML-DmD21    9 wing disc ML-DmD32    21 haltere disc ML-DmD17-c3    27 eye-antennal disc ML-DmD11    23 antennal disc ML-DmD20-c5    12 mixed discs ML-DmD4-c1    22 CNS ML-DmBG1-c1    25 CNS ML-DmBG2-c2    33 tumorous blood cells mbn2    43 ovary fGS/OSS    25 ovary OSC    27 ovary OSS    15 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    39 Schneider line 2 Sg4    16 embryonic 1182-4H    43 embryonic GM2    53 embryonic Kc167    43 embryonic S1    36 embryonic S3    24 leg disc CME L1    22 wing disc CME-W2    27 wing disc ML-DmD8    20 wing disc ML-DmD9    26 wing disc ML-DmD16-c3    23 wing disc ML-DmD21    9 wing disc ML-DmD32    21 haltere disc ML-DmD17-c3    27 eye-antennal disc ML-DmD11    23 antennal disc ML-DmD20-c5    12 mixed discs ML-DmD4-c1    22 CNS ML-DmBG1-c1    25 CNS ML-DmBG2-c2    33 tumorous blood cells mbn2    43 ovary fGS/OSS    25 ovary OSC    27 ovary OSS    15 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (39) Schneider line 2 Sg4    16 embryonic 1182-4H  (43) embryonic GM2  (53) embryonic Kc167  (43) embryonic S1  (36) embryonic S3    24 leg disc CME L1    22 wing disc CME-W2  27 wing disc ML-DmD8    20 wing disc ML-DmD9  26 wing disc ML-DmD16-c3    23 wing disc ML-DmD21    9 wing disc ML-DmD32    21 haltere disc ML-DmD17-c3  27 eye-antennal disc ML-DmD11    23 antennal disc ML-DmD20-c5    12 mixed discs ML-DmD4-c1    22 CNS ML-DmBG1-c1    25 CNS ML-DmBG2-c2  (33) tumorous blood cells mbn2  (43) ovary fGS/OSS    25 ovary OSC  27 ovary OSS    15 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    39 Schneider line 2 Sg4    16 embryonic 1182-4H    43 embryonic GM2    53 embryonic Kc167    43 embryonic S1    36 embryonic S3    24 leg disc CME L1    22 wing disc CME-W2    27 wing disc ML-DmD8    20 wing disc ML-DmD9    26 wing disc ML-DmD16-c3    23 wing disc ML-DmD21    9 wing disc ML-DmD32    21 haltere disc ML-DmD17-c3    27 eye-antennal disc ML-DmD11    23 antennal disc ML-DmD20-c5    12 mixed discs ML-DmD4-c1    22 CNS ML-DmBG1-c1    25 CNS ML-DmBG2-c2    33 tumorous blood cells mbn2    43 ovary fGS/OSS    25 ovary OSC    27 ovary OSS    15 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    39 Schneider line 2 Sg4    16 embryonic 1182-4H    43 embryonic GM2    53 embryonic Kc167    43 embryonic S1    36 embryonic S3    24 leg disc CME L1    22 wing disc CME-W2    27 wing disc ML-DmD8    20 wing disc ML-DmD9    26 wing disc ML-DmD16-c3    23 wing disc ML-DmD21    9 wing disc ML-DmD32    21 haltere disc ML-DmD17-c3    27 eye-antennal disc ML-DmD11    23 antennal disc ML-DmD20-c5    12 mixed discs ML-DmD4-c1    22 CNS ML-DmBG1-c1    25 CNS ML-DmBG2-c2    33 tumorous blood cells mbn2    43 ovary fGS/OSS    25 ovary OSC    27 ovary OSS    15 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    9 cold shock, 4-day adult    7 heat shock, 4-day adult    24 Cadmium 50 mM 6 hrs, larvae L3    6 Cadmium 50 mM 12 hrs, larvae L3    6 Cadmium 50 mM 48 hrs, 4-day adult    17 Cadmium 100 mM 48 hrs, 4-day adult    34 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    14 Zinc 5 mM 12 hrs, larvae L3    6 Zinc 4.5 mM 48 hrs, 4-day adult    8 Ethanol 2.5% 3 hrs, larvae L3    45 Ethanol 5% 3 hrs, larvae L3    8 Ethanol 10% 3 hrs, larvae L3    9 Caffeine 1.5 mg/ml 4 hrs, larvae L3    7 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    24 Caffeine 25 mg/ml 48 hrs, 4-day adult    11 Paraquat 5 mM 48 hrs, 4-day adult    25 Paraquat 10 mM 48 hrs, 4-day adult    32 Rotenone 2 μg 12 hrs, larvae L3    7 Rotenone 8 μg 12 hrs, larvae L3    9 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    9 cold shock, 4-day adult    7 heat shock, 4-day adult    24 Cadmium 50 mM 6 hrs, larvae L3    6 Cadmium 50 mM 12 hrs, larvae L3    6 Cadmium 50 mM 48 hrs, 4-day adult    17 Cadmium 100 mM 48 hrs, 4-day adult  (34) Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    14 Zinc 5 mM 12 hrs, larvae L3    6 Zinc 4.5 mM 48 hrs, 4-day adult    8 Ethanol 2.5% 3 hrs, larvae L3  (45) Ethanol 5% 3 hrs, larvae L3    8 Ethanol 10% 3 hrs, larvae L3    9 Caffeine 1.5 mg/ml 4 hrs, larvae L3    7 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    24 Caffeine 25 mg/ml 48 hrs, 4-day adult    11 Paraquat 5 mM 48 hrs, 4-day adult    25 Paraquat 10 mM 48 hrs, 4-day adult  (32) Rotenone 2 μg 12 hrs, larvae L3    7 Rotenone 8 μg 12 hrs, larvae L3    9 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    9 cold shock, 4-day adult    7 heat shock, 4-day adult    24 Cadmium 50 mM 6 hrs, larvae L3    6 Cadmium 50 mM 12 hrs, larvae L3    6 Cadmium 50 mM 48 hrs, 4-day adult    17 Cadmium 100 mM 48 hrs, 4-day adult    34 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    14 Zinc 5 mM 12 hrs, larvae L3    6 Zinc 4.5 mM 48 hrs, 4-day adult    8 Ethanol 2.5% 3 hrs, larvae L3    45 Ethanol 5% 3 hrs, larvae L3    8 Ethanol 10% 3 hrs, larvae L3    9 Caffeine 1.5 mg/ml 4 hrs, larvae L3    7 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    24 Caffeine 25 mg/ml 48 hrs, 4-day adult    11 Paraquat 5 mM 48 hrs, 4-day adult    25 Paraquat 10 mM 48 hrs, 4-day adult    32 Rotenone 2 μg 12 hrs, larvae L3    7 Rotenone 8 μg 12 hrs, larvae L3    9 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    9 cold shock, 4-day adult    7 heat shock, 4-day adult    24 Cadmium 50 mM 6 hrs, larvae L3    6 Cadmium 50 mM 12 hrs, larvae L3    6 Cadmium 50 mM 48 hrs, 4-day adult    17 Cadmium 100 mM 48 hrs, 4-day adult    34 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    14 Zinc 5 mM 12 hrs, larvae L3    6 Zinc 4.5 mM 48 hrs, 4-day adult    8 Ethanol 2.5% 3 hrs, larvae L3    45 Ethanol 5% 3 hrs, larvae L3    8 Ethanol 10% 3 hrs, larvae L3    9 Caffeine 1.5 mg/ml 4 hrs, larvae L3    7 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    24 Caffeine 25 mg/ml 48 hrs, 4-day adult    11 Paraquat 5 mM 48 hrs, 4-day adult    25 Paraquat 10 mM 48 hrs, 4-day adult    32 Rotenone 2 μg 12 hrs, larvae L3    7 Rotenone 8 μg 12 hrs, larvae L3    9 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    9 cold shock, 4-day adult    7 heat shock, 4-day adult    24 Cadmium 50 mM 6 hrs, larvae L3    6 Cadmium 50 mM 12 hrs, larvae L3    6 Cadmium 50 mM 48 hrs, 4-day adult    17 Cadmium 100 mM 48 hrs, 4-day adult    34 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    14 Zinc 5 mM 12 hrs, larvae L3    6 Zinc 4.5 mM 48 hrs, 4-day adult    8 Ethanol 2.5% 3 hrs, larvae L3    45 Ethanol 5% 3 hrs, larvae L3    8 Ethanol 10% 3 hrs, larvae L3    9 Caffeine 1.5 mg/ml 4 hrs, larvae L3    7 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    24 Caffeine 25 mg/ml 48 hrs, 4-day adult    11 Paraquat 5 mM 48 hrs, 4-day adult    25 Paraquat 10 mM 48 hrs, 4-day adult    32 Rotenone 2 μg 12 hrs, larvae L3    7 Rotenone 8 μg 12 hrs, larvae L3    9 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    9 cold shock, 4-day adult    7 heat shock, 4-day adult    24 Cadmium 50 mM 6 hrs, larvae L3    6 Cadmium 50 mM 12 hrs, larvae L3    6 Cadmium 50 mM 48 hrs, 4-day adult    17 Cadmium 100 mM 48 hrs, 4-day adult  (34) Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    14 Zinc 5 mM 12 hrs, larvae L3    6 Zinc 4.5 mM 48 hrs, 4-day adult    8 Ethanol 2.5% 3 hrs, larvae L3  (45) Ethanol 5% 3 hrs, larvae L3    8 Ethanol 10% 3 hrs, larvae L3    9 Caffeine 1.5 mg/ml 4 hrs, larvae L3    7 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    24 Caffeine 25 mg/ml 48 hrs, 4-day adult    11 Paraquat 5 mM 48 hrs, 4-day adult    25 Paraquat 10 mM 48 hrs, 4-day adult  32 Rotenone 2 μg 12 hrs, larvae L3    7 Rotenone 8 μg 12 hrs, larvae L3    9 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    9 cold shock, 4-day adult    7 heat shock, 4-day adult    24 Cadmium 50 mM 6 hrs, larvae L3    6 Cadmium 50 mM 12 hrs, larvae L3    6 Cadmium 50 mM 48 hrs, 4-day adult    17 Cadmium 100 mM 48 hrs, 4-day adult    34 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    14 Zinc 5 mM 12 hrs, larvae L3    6 Zinc 4.5 mM 48 hrs, 4-day adult    8 Ethanol 2.5% 3 hrs, larvae L3    45 Ethanol 5% 3 hrs, larvae L3    8 Ethanol 10% 3 hrs, larvae L3    9 Caffeine 1.5 mg/ml 4 hrs, larvae L3    7 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    24 Caffeine 25 mg/ml 48 hrs, 4-day adult    11 Paraquat 5 mM 48 hrs, 4-day adult    25 Paraquat 10 mM 48 hrs, 4-day adult    32 Rotenone 2 μg 12 hrs, larvae L3    7 Rotenone 8 μg 12 hrs, larvae L3    9 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    9 cold shock, 4-day adult    7 heat shock, 4-day adult    24 Cadmium 50 mM 6 hrs, larvae L3    6 Cadmium 50 mM 12 hrs, larvae L3    6 Cadmium 50 mM 48 hrs, 4-day adult    17 Cadmium 100 mM 48 hrs, 4-day adult    34 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    14 Zinc 5 mM 12 hrs, larvae L3    6 Zinc 4.5 mM 48 hrs, 4-day adult    8 Ethanol 2.5% 3 hrs, larvae L3    45 Ethanol 5% 3 hrs, larvae L3    8 Ethanol 10% 3 hrs, larvae L3    9 Caffeine 1.5 mg/ml 4 hrs, larvae L3    7 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    24 Caffeine 25 mg/ml 48 hrs, 4-day adult    11 Paraquat 5 mM 48 hrs, 4-day adult    25 Paraquat 10 mM 48 hrs, 4-day adult    32 Rotenone 2 μg 12 hrs, larvae L3    7 Rotenone 8 μg 12 hrs, larvae L3    9 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_01 mE1_20_mRNA_expression_cluster_03
External Data & Images
Linkouts	BDGP expression data • LD41715 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0037327 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG2087-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for PEK Stages(s) 4-6 Stages(s) 9-10 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal | pupal stage, with Scer\GAL4GMR.PF PEKScer\UAS.cMa viable PEKEY09578 viable, with Scer\GAL4pnr-MD237 PEKGD5584 Sterility Allele fertile PEKEY09578 Other Phenotypes Allele mitotic cell cycle defective | conditional | third instar larval stage, with Scer\GAL4αTub84B.PL PEKScer\UAS.cMa mitotic cell cycle defective | third instar larval stage, with Scer\GAL4GMR.PF PEKScer\UAS.cMa Phenotype manifest in Allele eye | temperature conditional, with Scer\GAL4GMR.PF PEKScer\UAS.cMa eye disc, with Scer\GAL4GMR.PF PEKScer\UAS.cMa eye disc posterior to the morphogenetic furrow, with Scer\GAL4GMR.PF PEKScer\UAS.cMa eye disc posterior to the morphogenetic furrow | conditional, with Scer\GAL4αTub84B.PL PEKScer\UAS.cMa
Classical Alleles ( 4 )
For All Classical Alleles Show
Allele of PEK Class Mutagen Stocks Known lesion PEK5-SZ-3285 1 -- PEKe01744 piggyBac transposase 1 -- PEKEY09578 P-element activity 1 -- PEKMI05683 1 --
Alleles Carried on Transgenic Constructs ( 14 )
For All Alleles Carried on Transgenic Constructs Show
Allele of PEK Class Mutagen Stocks Known lesion PEKGD5584 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes PEKGL00030 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes PEKHMJ02063 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes PEKK671R.MtnA.T:Hsap\MYC,T:Zzzz\His6 in vitro construct - amino acid replacement 0 Yes PEKK671R.MtnA.T:SV5\V5,T:Zzzz\His6 in vitro construct - amino acid replacement 0 Yes PEKKK100348 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes PEKKR.Scer\UAS in vitro construct - regulatory fusion 0 Yes PEKMtnA.T:Hsap\MYC,T:Zzzz\His6 in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes PEKMtnA.T:SV5\V5,T:Zzzz\His6 in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes PEKN260A.MtnA.T:SV5\V5,T:Zzzz\His6 in vitro construct - amino acid replacement 0 Yes PEKScer\UAS.cMa in vitro construct - regulatory fusion 0 Yes PEKΔNt.T:SV5\V5 in vitro construct - regulatory fusion in vitro construct - deletion 0 Yes PEKΔSP.T:SV5\V5 in vitro construct - regulatory fusion in vitro construct - deletion 0 Yes PEKΔTM.T:SV5\V5 in vitro construct - regulatory fusion in vitro construct - deletion 0 Yes
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD5584} NA P{KK100348} NA P{TRiP.GL00030} NA P{TRiP.HMJ02063} NA P{UAS-PEK.KR} NA P{UAS-PEK.M} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EPgy2}PEKEY09578 NA miscellaneous insertions Mi{MIC}PEKMI05683 NA P{RS5}PEK5-SZ-3285 NA PBac{RB}PEKe01744 NA
Gene Ontology: Function, Process & Cellular Component ( 12 unique terms )
Terms Based on Experimental Evidence ( 2 terms )
Molecular Function
CV term Evidence References
elongation factor-2 kinase activity inferred from direct assay (Pomar et al., 2003)
Biological Process
CV term Evidence References
regulation of G2/M transition of mitotic cell cycle inferred from mutant phenotype (Malzer et al., 2010)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 11 terms )
Molecular Function
CV term Evidence References
ATP binding inferred from electronic annotation with InterPro:IPR000719, InterPro:IPR017441 (FlyBase Curators et al., 2004-) elongation factor-2 kinase activity inferred from sequence or structural similarity with NCBI_gi:4758892 (FlyBase, 1992-) non-traceable author statement (McNaughton et al., 2000, Zhang et al., 2000, Sood, 1999.10.8, Pomar-Ballestero, 2001.5.8, Swiss-Prot Project Members, 2001.8.20) protein kinase activity non-traceable author statement (Morrison et al., 2000) protein serine/threonine kinase activity inferred from sequence or structural similarity with worm pek-1 (Sood et al., 2000)
Biological Process
CV term Evidence References
ER overload response non-traceable author statement (Sood, 1999.10.8) negative regulation of translation non-traceable author statement (Geething et al., 2000) protein phosphorylation inferred from electronic annotation with InterPro:IPR000719, InterPro:IPR008271 (FlyBase Curators et al., 2004-) non-traceable author statement (Morrison et al., 2000) regulation of translational initiation in response to stress inferred from sequence or structural similarity with worm pek-1 (Sood et al., 2000) response to unfolded protein non-traceable author statement (Geething et al., 2000)
Cellular Component
CV term Evidence References
endoplasmic reticulum non-traceable author statement (Zhang et al., 2000, Swiss-Prot Project Members, 2001.8.20) endoplasmic reticulum lumen non-traceable author statement (McNaughton et al., 2000)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
PEK enzymatic study, autoradiography, anti tag coimmunoprecipitation, anti tag western blot (Pomar et al., 2003) PEK - CG11455 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) PEK - CG5196 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) PEK - eIF-2α enzymatic study, autoradiography (Pomar et al., 2003)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions PEK allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 65862 DroID - A comprehensive database of gene and protein interactions. • FBgn0037327 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 40653 SignaLink - A protein-protein and protein-miRNA interaction database with multi-layered structure and multiple confidence scores. • Q9NIV1
Orthologs
OrthoDB Orthologs (45) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6Z3704 Dipteran inclusive ortholog search EOG6WQ19J Insect inclusive ortholog search EOG63TXQF Arthropod inclusive ortholog search EOG68GTJ6 Metazoa inclusive ortholog search EOG6ZPSN3
Orthologs in Drosophila Species (EOG6Z3704)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\PEK     Drosophila simulans   Dsim\GD19618 Y   Drosophila sechellia   Dsec\GM10634 Y   Drosophila erecta   Dere\GG11023 Y   Drosophila yakuba   Dyak\GE25281 Y   Drosophila ananassae   Dana\GF17710 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA15232 Y   Drosophila persimilis   Dper\GL22166 Y   Drosophila willistoni   Dwil\GK22838 Y   Drosophila virilis   Dvir\GJ24717 Y   Drosophila mojavensis   Dmoj\GI23641 Y   Drosophila grimshawi   Dgri\GH22593 Y
Orthologs in non-Drosophila Dipterans (EOG6WQ19J)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL003939   Anopheles gambiae Malaria mosquito  Agam\AGAP013266   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ018256
Orthologs in non-Dipteran Insects (EOG63TXQF)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\PEK   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG005280   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH17320   Atta cephalotes Leafcutter ant  Acep\ACEP13003   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL18806   Linepithema humile Argentine ant  Lhum\LH18333   Pogonomyrmex barbatus Red harvester ant  Pbar\PB15667   Solenopsis invicta Red fire ant  Sinv\SINV16120   Acyrthosiphon pisum Pea aphid  Apim\ACYPI007358   Bombyx mori Silkmoth  Bmor\BGIBMGA008626   Pediculus humanus Human body louse  Phum\PHUM002650   Tribolium castaneum Red flour beetle  Tcas\TC004612
Orthologs in non-Insect Arthropods (EOG68GTJ6)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\JGI_V11_331792   Daphnia pulex Water flea  Dpux\JGI_V11_316365   Daphnia pulex Water flea  Dpux\Tpsb2   Daphnia pulex Water flea  Dpux\JGI_V11_65929   Ixodes scapularis Deer tick  Isca\ISCW014712
Orthologs in non-Arthropod Metazoa (EOG6ZPSN3)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\C36B7.2   Caenorhabditis elegans Nematode  Cele\zyg-1   Caenorhabditis elegans Nematode  Cele\Y38E10A.8   Caenorhabditis elegans Nematode  Cele\pek-1   Caenorhabditis elegans Nematode  Cele\kgb-1   Caenorhabditis elegans Nematode  Cele\kgb-2   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_026724gn   Danio rerio Zebrafish  Drer\eif2ak3   Xenopus tropicalis Western clawed frog  Xtro\eif2ak3   Gallus gallus Domestic chicken  Ggal\EIF2AK3   Mus musculus House mouse  Mmus\Eif2ak3   Rattus norvegicus Norway rat  Rnor\Eif2ak3   Homo sapiens Human  Hsap\EIF2AK3
Human Orthologs (1)
Gene OMIM HGNC Hsap\EIF2AK3
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD19618 Drosophila sechellia Dsec\GM10634 Drosophila erecta Dere\GG11023 Drosophila yakuba Dyak\GE25281 Drosophila ananassae Dana\GF17710 Drosophila pseudoobscura pseudoobscura Dpse\GA15232 Drosophila persimilis Dper\GL22166 Drosophila willistoni Dwil\GK22838 Drosophila virilis Dvir\GJ24717 Drosophila mojavensis Dmoj\GI23641 Drosophila grimshawi Dgri\GH22593
Stocks & Reagents
Stocks Listed in FlyBase ( 7 )
Bloomington	42499 y1 v1; P{TRiP.HMJ02063}attP40 42102 y1 w*; Mi{MIC}PEKMI05683 17582 y1 w67c23; P{EPgy2}PEKEY09578 35162 y1 sc* v1; P{TRiP.GL00030}attP2
Harvard	- PBac{RB}PEKe01744
Kyoto	125978 w1118; P{RS5}PEK5-SZ-3285
VDRC	v16427 w1118; P{GD5584}v16427
Genomic Clones ( 2 )
	BACR24O24 BACR34M23 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 75 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD41715
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT21104 AT24602 LD02504 LD04244 LD06231 LD08802 LD13632 LD14380 LD19676 LD23787 LD25978 LD26631 LD27617 LD35903 LD41550 LD41884 LP07933 RE03266 RE19675 RE20821 RE29467 RE29739 RE49818 RE63482 SD02621 SD03080 SD03935 SD05870 SD08514 SD08526 SD13171 SD19763
Other clones	16388 30558 33823 42562 45472 50253 58954 78305 107582 CK01.29B.B2 CK01.117B.E9 EC03385 EC051516 EC052016 EC053540 EK005714 EK025937 EK139247 EK157421 EK161052 EK176339 EK181958 EK208043 EK212804 EK233317 EK244559 RH70084 RP003037707 RP003063975 RP003110684 RP003188545 RP003280725 RP003308151 RP003311373 RP003338365 RP003466989 RP003483416 RP003483566 RP003617391 RP003632667 RP003643719 RP003649226
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0037327 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 40653
Antibody Information
	polyclonal (Malzer et al., 2010, Pomar et al., 2003)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: PEK CG2087 (FlyBase, 1996-)
Source for database merge of	Source for merge of: PEK Perk (Cavener, 2003.12.17)
Additional comments	Source for identity of PEK CG2087 was sequence comparison (date:000401). (FlyBase, 1996-)
Other Comments
	Changes in expression profiles associated with the unfolded protein response have been analyzed in S2 cells following treatment with dsRNA made from templates generated with primers directed against this gene. (Hollien and Weissman, 2006) dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology. (Kiger et al., 2003)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_141281 NM_001275353 NM_001275354 RefSeq (Proteins) • NP_649538 NP_001262282 NP_001262283 DDBJ / EMBL / GenBank • AA390738 AA439740 AAF52028 AAF61200 AAM11184 AF193340 AGB95665 AGB95666 AI515986 AJ313085 AW943572 AY094831 CAC85207 CL526124 CZ479556 Entrez Gene - A searchable database of RefSeq genes. • 40653 UniProtKB/Swiss-Prot • Q9NIV1
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Pyrrolo-quinoline quinone beta-propeller repeat (IPR018391) Protein kinase, catalytic domain (IPR000719) Serine/threonine-protein kinase, active site (IPR008271) Protein kinase-like domain (IPR011009) Quinonprotein alcohol dehydrogenase-like superfamily (IPR011047) Protein kinase, ATP binding site (IPR017441) Quinonprotein alcohol dehydrogenase-like domain (IPR027295) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • LD41715
Linkouts
	BioGRID - A database of protein and genetic interactions • 65862 DroID - A comprehensive database of gene and protein interactions. • FBgn0037327 DRSC - Results from RNAi screens. • FBgn0037327 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0037327 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG2087-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0037327 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 40653 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 40653 modMine - Data generated by the modENCODE project. • FBgn0037327 SignaLink - A protein-protein and protein-miRNA interaction database with multi-layered structure and multiple confidence scores. • Q9NIV1
Synonyms & Secondary IDs ( 13 )
Reported As
Symbol Synonym	CG2087 (Pile et al., 2003, Morrison et al., 2000, Hollien and Weissman, 2006, Keleman et al., 2009.8.5, Ni et al., 2011.7.19, Ni et al., 2010.12.1) DmPEK (Sood et al., 2000) DPERK (Pomar et al., 2003, Pomar-Ballestero, 2001.5.8) DpERK (Ninov et al., 2009) EIF2-like (Inlow and Restifo, 2004, Morrison et al., 2000) PEK (Carbone et al., 2009, Font-Burgada et al., 2008, Farny et al., 2009, Kim et al., 2012) pek (Smibert et al., 2012) Perk (Cavener et al., 2000.3.10, Ryoo and Steller, 2007) PERK (Zhang et al., 2000, Geething et al., 2000, McNaughton et al., 2000, Hollien and Weissman, 2006, Mounir et al., 2011, Liu et al., 2009, Greene et al., 2005, Malzer et al., 2010) perk (Kang et al., 2012) pERK (Kirilly et al., 2011)
Name Synonym	pancreatic eIF-2α kinase (Sood et al., 2000) pancreatic eIF2α kinase (Farny et al., 2009) PEK   PERK (Kim et al., 2012)
Secondary FlyBase IDs
	FBgn0041196
References ( 50 )
Generate a list of	All references relating to this gene ( 50 )
List References by type	Research paper  ( 17 ) Supplementary material  ( 8 ) Review  ( 1 ) Personal communication to FlyBase  ( 12 ) Abstract  ( 3 ) FlyBase analysis  ( 3 ) DNA/RNA sequence record  ( 2 ) Protein sequence record  ( 1 ) Website  ( 1 ) Curated genome annotation  ( 2 )
Recent research papers ( 5 )
	Kang et al., 2012, Nat. Cell Biol. 14(4): 409--415 CDK5 and MEKK1 mediate pro-apoptotic signalling following endoplasmic reticulum stress in an autosomal dominant retinitis pigmentosa model. [FBrf0217924] Kim et al., 2012, J. Biol. Chem. 287(9): 6628--6641 Glutathione s-transferase omega 1 activity is sufficient to suppress neurodegeneration in a Drosophila model of Parkinson disease. [FBrf0217543] Palgi et al., 2012, BMC Genomics 13: 134 Gene expression analysis of Drosophilaa Manf mutants reveals perturbations in membrane traffic and major metabolic changes. [FBrf0218515] Kirilly et al., 2011, Development 138(23): 5087--5097 Self-maintained escort cells form a germline stem cell differentiation niche. [FBrf0216598] Mounir et al., 2011, Sci. Signal. 4(192): ra62 Akt Determines Cell Fate Through Inhibition of the PERK-eIF2{alpha} Phosphorylation Pathway. [FBrf0216247] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...