FlyBase Gene Report: Dmel\CG2104

General Information

Symbol

Dmel\CG2104

Species

D. melanogaster

Name

Annotation Symbol

CG2104

Feature Type

protein_coding_gene

FlyBase ID

FBgn0037365

Gene Model Status

Current

Stock Availability

4 publicly available

Enzyme Name (EC)

peptidylprolyl isomerase (5.2.1.8)

Gene Summary

Predicted to enable peptidyl-prolyl cis-trans isomerase activity and protein tyrosine phosphatase activator activity. Predicted to be involved in mitotic spindle organization. Predicted to be part of protein phosphatase type 2A complex. Predicted to be active in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in Parkinson's disease 25. Orthologous to human PTPA (protein phosphatase 2 phosphatase activator). (Alliance, FBgn0037365 )

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All Summaries

Alliance
Auto summary
Gene Group
Interactive Fly

Key Links

Genomic Location

Cytogenetic map

83C1-83C1

Sequence location

3R:5,690,891..5,693,286 [-]

Recombination map

3-47.5

RefSeq locus

NT_033777 REGION:5690891..5693286

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

GO Summary Ribbons

enzyme

regulator

receptor

receptor binding

transporter

structural molecule

cytoskeletal binding

DNA binding

RNA binding

transcription factor

small molecule binding

metal ion binding

lipid binding

carbohydrate binding

other molecular_function

molecular function

cell cycle/proliferation

cell organization/biogenesis

transport/localization

development

reproduction

immune system

nervous system process

behavior

response to stimulus

signaling

gene expression

protein metabolism

DNA metabolism

small molecule metabolism

other biological_process

biological process

extracellular region

cytosol

cytoskeleton

mitochondrion

nucleus

chromosome

membrane

cell periphery

cell junction

cell projection

endomembrane system

synapse

macromolecular complex

other cellular_component

cellular component

Gene Ontology (GO) Annotations (7 terms)

Molecular Function (3 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

enables peptidyl-prolyl cis-trans isomerase activity

inferred from biological aspect of ancestor with PANTHER:PTN000000630

(GO Reference Genome Project, 2011-)

enables phosphatase activator activity

inferred from electronic annotation with InterPro:IPR004327, InterPro:IPR037218

(InterPro Project Members, 2004-)

enables protein tyrosine phosphatase activator activity

inferred from biological aspect of ancestor with PANTHER:PTN000000630

(GO Reference Genome Project, 2011-)

Biological Process (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

involved_in mitotic spindle organization

inferred from biological aspect of ancestor with PANTHER:PTN000000630

(GO Reference Genome Project, 2011-)

Cellular Component (3 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

is_active_in cytoplasm

inferred from biological aspect of ancestor with PANTHER:PTN000000630

(GO Reference Genome Project, 2011-)

is_active_in nucleus

inferred from biological aspect of ancestor with PANTHER:PTN000000630

(GO Reference Genome Project, 2011-)

part_of protein phosphatase type 2A complex

inferred from biological aspect of ancestor with PANTHER:PTN000000630

(GO Reference Genome Project, 2011-)

Gene Group (FlyBase)

PROTEIN PHOSPHATASE 2 PHOSPHATASE ACTIVATORS

Protein Family (UniProt)

Protein Signatures (InterPro)

Catalytic Activity (EC/Rhea)

peptidyl-prolyl cis-trans isomerase activity

[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0) (5.2.1.8)

RHEA 16237:

Summaries

Gene Model and Products

Expression Data

Gene ToolKit

The gene 'ToolKit' contains a set of key genetic reagents that can be used to study a gene. A single reagent for each category is chosen based on frequency of usage, and stock availability. Click "See all" to view all the reagents for the category.

Category	Common alleles (# stocks)
Classical and Insertion Alleles
Loss of function allele
Amorphic allele
Fluorescently-tagged allele
Transgenic Constructs
UAS RNAi
UAS wild-type cDNA
Untagged genomic rescue
Fluorescently-tagged genomic rescue
Aberrations
Deficiency
Duplication

Alleles, Insertions, Transgenic Constructs, and Aberrations

Variants

Phenotypes

Orthologs

Paralogs

Human Disease Associations

Functional Complementation Data

Interactions

Pathways

Class of Gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

3-47.5

Cytogenetic map

83C1-83C1

Sequence location

3R:5,690,891..5,693,286 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

83C1-83C1

Limits computationally determined from genome sequence between P{lacW}Atu^s1938 and P{lacW}cas^j1C2

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

3-47.5

(FlyBase, 2016)

3-44.1

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Other Comments

Relationship to Other Genes

Nomenclature History

Synonyms and Secondary IDs (1)

Datasets (0)

External Crossreferences and Linkouts ( 30 )

References (22)

The following external sites may use different assemblies or annotations than FlyBase.

GO Summary Ribbons

Expression Summary Ribbons

5.15

Gene ToolKit

Disease Model Summary Ribbon

Report Sections