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Gene Dmel\jagn

General Information
Symbol	Dmel\jagn	Species	D. melanogaster
Name	jagunal	Annotation symbol	CG10978
Feature type	protein_coding_gene	FlyBase ID	FBgn0037374
Gene Model Status	Current	Stock availability	1 publicly available
Genomic Location
Chromosome (arm)	3R	Recombination map
Cytogenetic map	83C3-83C3	Sequence location	3R:1,605,031..1,607,030 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene jagunal is referred to in FlyBase by the symbol Dmel\jagn (CG10978, FBgn0037374). It is a protein_coding_gene from Drosophila melanogaster. Its molecular function is unknown. There is experimental evidence that it is involved in the biological process: vitellogenesis; chaeta development; oocyte growth; establishment of ER localization; exocytosis; endoplasmic reticulum organization; chaeta morphogenesis. 11 alleles are reported. No phenotypic data is available. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: Protein of unknown function DUF1352. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderately high expression. Peak expression observed within 00-18 hour embryonic stages, at stages throughout the larval period, at stages throughout the pupal period, in adult female stages. Summary of FlyAtlas Anatomical Expression Data: Two or more Affy2 ProbeSets identify exons of this gene. This is a summary of the tissue expression peaks exhibited in at least one of these ProbeSets. Expression at high levels in the following post-embryonic organs or tissues: adult crop, larval midgut, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult spermathecae, larval carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult ovary, adult male reproductive system, adult carcass. Gene sequence location is 3R:1605031..1607030.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2011_10	Controlled Vocabulary Terms day 42 of adulthood day 41 of adulthood day 30 of adulthood day 49 of adulthood day 17 of adulthood day 45 of adulthood day 8 of adulthood day 26 of adulthood day 21 of adulthood day 13 of adulthood day 25 of adulthood day 22 of adulthood day 20 of adulthood day 39 of adulthood day 7 of adulthood day 36 of adulthood day 11 of adulthood day 37 of adulthood day 27 of adulthood day 18 of adulthood day 19 of adulthood day 28 of adulthood day 9 of adulthood day 29 of adulthood adult heart day 40 of adulthood day 16 of adulthood day 24 of adulthood day 15 of adulthood day 33 of adulthood day 43 of adulthood day 47 of adulthood day 38 of adulthood day 32 of adulthood day 48 of adulthood day 23 of adulthood day 35 of adulthood day 12 of adulthood day 10 of adulthood day 31 of adulthood day 34 of adulthood day 44 of adulthood day 14 of adulthood day 46 of adulthood
FB2012_01	Sequence features HFA12152 BKN27655
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 83C3-83C3   Limits computationally determined from genome sequence between P{lacW}casj1C2 and P{PZ}lab01241
Experimentally Determined Cytological Location
Cytogenetic map Notes References 83C-83C     (Lee and Cooley, 2004)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\jagn for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) jagn-RA FBtr0078625  NM_141328   1110   197 jagn-RB FBtr0078624  NM_169103   1655   197
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein jagn-PA   FBpp0078274   23.0   197   6.77     NP_649585   AAN14321 jagn-PB   FBpp0078273   23.0   197   6.77     NP_731002   AAF51956
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Protein of unknown function DUF1352 (IPR009787)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA202414   AA391085   AA696169   AA697596   AA820059   AA821197   AA950878   AA951923   AE014297 AAF51956   AE014297 AAN14321   AI134943   AI239209   AI516683   AI518543   AW943409   AY061443 AAL28991   BE977733   BF499288   BF500046   BF502644   BI161761   BI161762   BI162769   BI162770   BI167060   BI228688   BI229243   BI232875   BI232914   BI236522   BI237970   BI239795   BI240831   BI361398   BI363550   BI372831   BI486505   BI577846   BI579650   BI635483   BI637102   BI638943   CK658451   CO186259   CO282183   CO284327   CO286544   CO292283   CO294467   CO294997   CO301989   CO309440   CO312122   CO313437   CO322703   CO326734   CO339899   CO340823   EC063612   EC074193   EC087379   EC088104   EC194553   EC200037   EC200606   EC213428   EC224370   EC234004   EC236066   EC254668   EC260135   EL871829   EL871830   EL883954   EV576345   GH742204   GH744168   GH744276   GH744818   GH745561   GH745616   GH747034   GH747177   GH761792   GH761886   GH762553   GH764207   GH764577   GH767379   GH768034   GH768871   GH769060   GH779713
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q7K1V5 E2QD00
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 7 of adulthood -- day 49 of adulthood   adult heart   (Cammarato et al., 2011)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0037374    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0037374 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderately high expression. Peak expression observed within 00-18 hour embryonic stages, at stages throughout the larval period, at stages throughout the pupal period, in adult female stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0037374 expression level Developmental Stage   Expression Level embryo 00-02hr    4750 embryo 02-04hr    5321 embryo 04-06hr    4021 embryo 06-08hr    3501 embryo 08-10hr    4311 embryo 10-12hr    6189 embryo 12-14hr    6907 embryo 14-16hr    7328 embryo 16-18hr    6225 embryo 18-20hr    3785 embryo 20-22hr    3251 embryo 22-24hr    3847 larva L1    4436 larva L2    5596 larva L3 12hr old    4230 larva L3 puffstage 1-2    2475 larva L3 puffstage 3-6    2865 larva L3 puffstage 7-9    4073 white prepupae new    4429 white prepupae 12hr    3056 white prepupae 24hr    2305 pupae 2d postWPP    4071 pupae 3d postWPP    5431 pupae 4d postWPP    3568 adult male 01day    3372 adult male 05day    2343 adult male 30day    2066 adult female 01day    4046 adult female 05day    4212 adult female 30day    3884 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (4750) embryo 02-04hr  (5321) embryo 04-06hr  (4021) embryo 06-08hr  (3501) embryo 08-10hr  (4311) embryo 10-12hr  (6189) embryo 12-14hr  (6907) embryo 14-16hr  (7328) embryo 16-18hr  (6225) embryo 18-20hr  (3785) embryo 20-22hr  (3251) embryo 22-24hr  (3847) larva L1  (4436) larva L2  (5596) larva L3 12hr old  (4230) larva L3 puffstage 1-2  (2475) larva L3 puffstage 3-6  (2865) larva L3 puffstage 7-9  (4073) white prepupae new  (4429) white prepupae 12hr  (3056) white prepupae 24hr  (2305) pupae 2d postWPP  (4071) pupae 3d postWPP  (5431) pupae 4d postWPP  (3568) adult male 01day  (3372) adult male 05day  (2343) adult male 30day  (2066) adult female 01day  (4046) adult female 05day  (4212) adult female 30day  (3884) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (4750) embryo 02-04hr  (5321) embryo 04-06hr  (4021) embryo 06-08hr  (3501) embryo 08-10hr  (4311) embryo 10-12hr  (6189) embryo 12-14hr  (6907) embryo 14-16hr  (7328) embryo 16-18hr  (6225) embryo 18-20hr  (3785) embryo 20-22hr  (3251) embryo 22-24hr  (3847) larva L1  (4436) larva L2  (5596) larva L3 12hr old  (4230) larva L3 puffstage 1-2  (2475) larva L3 puffstage 3-6  (2865) larva L3 puffstage 7-9  (4073) white prepupae new  (4429) white prepupae 12hr  (3056) white prepupae 24hr  (2305) pupae 2d postWPP  (4071) pupae 3d postWPP  (5431) pupae 4d postWPP  (3568) adult male 01day  (3372) adult male 05day  (2343) adult male 30day  (2066) adult female 01day  (4046) adult female 05day  (4212) adult female 30day  (3884) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    4750 embryo 02-04hr    5321 embryo 04-06hr    4021 embryo 06-08hr    3501 embryo 08-10hr    4311 embryo 10-12hr    6189 embryo 12-14hr    6907 embryo 14-16hr    7328 embryo 16-18hr    6225 embryo 18-20hr    3785 embryo 20-22hr    3251 embryo 22-24hr    3847 larva L1    4436 larva L2    5596 larva L3 12hr old    4230 larva L3 puffstage 1-2    2475 larva L3 puffstage 3-6    2865 larva L3 puffstage 7-9    4073 white prepupae new    4429 white prepupae 12hr    3056 white prepupae 24hr    2305 pupae 2d postWPP    4071 pupae 3d postWPP    5431 pupae 4d postWPP    3568 adult male 01day    3372 adult male 05day    2343 adult male 30day    2066 adult female 01day    4046 adult female 05day    4212 adult female 30day    3884 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    4750 embryo 02-04hr    5321 embryo 04-06hr    4021 embryo 06-08hr    3501 embryo 08-10hr    4311 embryo 10-12hr    6189 embryo 12-14hr    6907 embryo 14-16hr    7328 embryo 16-18hr    6225 embryo 18-20hr    3785 embryo 20-22hr    3251 embryo 22-24hr    3847 larva L1    4436 larva L2    5596 larva L3 12hr old    4230 larva L3 puffstage 1-2    2475 larva L3 puffstage 3-6    2865 larva L3 puffstage 7-9    4073 white prepupae new    4429 white prepupae 12hr    3056 white prepupae 24hr    2305 pupae 2d postWPP    4071 pupae 3d postWPP    5431 pupae 4d postWPP    3568 adult male 01day    3372 adult male 05day    2343 adult male 30day    2066 adult female 01day    4046 adult female 05day    4212 adult female 30day    3884 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0037374 expression level Developmental Stage   Expression Level embryo 00-02hr    4750 embryo 02-04hr    5321 embryo 04-06hr    4021 embryo 06-08hr    3501 embryo 08-10hr    4311 embryo 10-12hr    6189 embryo 12-14hr    6907 embryo 14-16hr    7328 embryo 16-18hr    6225 embryo 18-20hr    3785 embryo 20-22hr    3251 embryo 22-24hr    3847 larva L1    4436 larva L2    5596 larva L3 12hr old    4230 larva L3 puffstage 1-2    2475 larva L3 puffstage 3-6    2865 larva L3 puffstage 7-9    4073 white prepupae new    4429 white prepupae 12hr    3056 white prepupae 24hr    2305 pupae 2d postWPP    4071 pupae 3d postWPP    5431 pupae 4d postWPP    3568 adult male 01day    3372 adult male 05day    2343 adult male 30day    2066 adult female 01day    4046 adult female 05day    4212 adult female 30day    3884 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (4750) embryo 02-04hr  (5321) embryo 04-06hr  (4021) embryo 06-08hr  (3501) embryo 08-10hr  (4311) embryo 10-12hr  (6189) embryo 12-14hr  (6907) embryo 14-16hr  (7328) embryo 16-18hr  (6225) embryo 18-20hr  (3785) embryo 20-22hr  (3251) embryo 22-24hr  (3847) larva L1  (4436) larva L2  (5596) larva L3 12hr old  (4230) larva L3 puffstage 1-2  (2475) larva L3 puffstage 3-6  (2865) larva L3 puffstage 7-9  (4073) white prepupae new  (4429) white prepupae 12hr  (3056) white prepupae 24hr  (2305) pupae 2d postWPP  (4071) pupae 3d postWPP  (5431) pupae 4d postWPP  (3568) adult male 01day  (3372) adult male 05day  (2343) adult male 30day  (2066) adult female 01day  (4046) adult female 05day  (4212) adult female 30day  (3884) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (4750) embryo 02-04hr  (5321) embryo 04-06hr  (4021) embryo 06-08hr  (3501) embryo 08-10hr  (4311) embryo 10-12hr  (6189) embryo 12-14hr  (6907) embryo 14-16hr  (7328) embryo 16-18hr  (6225) embryo 18-20hr  (3785) embryo 20-22hr  (3251) embryo 22-24hr  (3847) larva L1  (4436) larva L2  (5596) larva L3 12hr old  (4230) larva L3 puffstage 1-2  (2475) larva L3 puffstage 3-6  (2865) larva L3 puffstage 7-9  (4073) white prepupae new  (4429) white prepupae 12hr  (3056) white prepupae 24hr  2305 pupae 2d postWPP  (4071) pupae 3d postWPP  (5431) pupae 4d postWPP  (3568) adult male 01day  (3372) adult male 05day  2343 adult male 30day  2066 adult female 01day  (4046) adult female 05day  (4212) adult female 30day  (3884) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    4750 embryo 02-04hr    5321 embryo 04-06hr    4021 embryo 06-08hr    3501 embryo 08-10hr    4311 embryo 10-12hr    6189 embryo 12-14hr    6907 embryo 14-16hr    7328 embryo 16-18hr    6225 embryo 18-20hr    3785 embryo 20-22hr    3251 embryo 22-24hr    3847 larva L1    4436 larva L2    5596 larva L3 12hr old    4230 larva L3 puffstage 1-2    2475 larva L3 puffstage 3-6    2865 larva L3 puffstage 7-9    4073 white prepupae new    4429 white prepupae 12hr    3056 white prepupae 24hr    2305 pupae 2d postWPP    4071 pupae 3d postWPP    5431 pupae 4d postWPP    3568 adult male 01day    3372 adult male 05day    2343 adult male 30day    2066 adult female 01day    4046 adult female 05day    4212 adult female 30day    3884 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    4750 embryo 02-04hr    5321 embryo 04-06hr    4021 embryo 06-08hr    3501 embryo 08-10hr    4311 embryo 10-12hr    6189 embryo 12-14hr    6907 embryo 14-16hr    7328 embryo 16-18hr    6225 embryo 18-20hr    3785 embryo 20-22hr    3251 embryo 22-24hr    3847 larva L1    4436 larva L2    5596 larva L3 12hr old    4230 larva L3 puffstage 1-2    2475 larva L3 puffstage 3-6    2865 larva L3 puffstage 7-9    4073 white prepupae new    4429 white prepupae 12hr    3056 white prepupae 24hr    2305 pupae 2d postWPP    4071 pupae 3d postWPP    5431 pupae 4d postWPP    3568 adult male 01day    3372 adult male 05day    2343 adult male 30day    2066 adult female 01day    4046 adult female 05day    4212 adult female 30day    3884 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0037374    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0037374 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Two or more Affy2 ProbeSets identify exons of this gene. This is a summary of the tissue expression peaks exhibited in at least one of these ProbeSets. Expression at high levels in the following post-embryonic organs or tissues: adult crop, larval midgut, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult spermathecae, larval carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult ovary, adult male reproductive system, adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Heatmap Tissue   Expression Level Larval Central Nervous System no informative data Larval Midgut no informative data Larval Hindgut no informative data Larval Malpighian Tubules no informative data Larval Fat Body no informative data Larval Salivary Gland no informative data Larval Trachea no informative data Larval Carcass no informative data Adult Head no informative data Adult Eye no informative data Adult Brain no informative data Adult Thoracic-Abdominal Ganglion no informative data Adult Crop no informative data Adult Midgut no informative data Adult Hindgut no informative data Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart no informative data Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary no informative data Adult Testis no informative data Adult Male Accessory Gland no informative data Adult Carcass no informative data modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_09
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0037374 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG10978-RA;CG10978-RB FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for jagn Stages(s) 1-3 Stages(s) 4-6 Stages(s) 7-8 Stages(s) 9-10 Stages(s) 11-12
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal | first instar larval stage | recessive jagnK38X jagnQ21X jagnW153X lethal | recessive jagnR190X lethal | recessive | second instar larval stage jagnK38X jagnQ21X jagnW153X semi-lethal | recessive jagnD16N Phenotype manifest in Allele endoplasmic reticulum & oocyte | germ-line clone jagnQ21X macrochaeta | somatic clone jagnQ21X microchaeta | somatic clone jagnQ21X microvillus & oocyte | germ-line clone jagnQ21X nurse cell | germline clone jagnQ21X oocyte | germline clone jagnQ21X jagnK38X jagnW153X wing margin bristle | somatic clone jagnQ21X yolk granule & oocyte | germ-line clone jagnQ21X
Classical Alleles ( 6 )
For All Classical Alleles Show
Allele of jagn Class Mutagen Stocks Known lesion jagnG4067 P-element activity 1 -- jagnD16N ethyl methanesulfonate 0 Yes jagnK38X ethyl methanesulfonate 0 Yes jagnQ21X 0 Yes jagnR190X ethyl methanesulfonate 0 Yes jagnW153X ethyl methanesulfonate 0 Yes
Alleles Carried on Transgenic Constructs ( 5 )
For All Alleles Carried on Transgenic Constructs Show
Allele of jagn Class Mutagen Stocks Known lesion jagnGD4632 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes jagnKK107655 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes jagnScer\UAS.P\T.cLa in vitro construct - regulatory fusion 0 Yes jagnT:Avic\GFP-YFP.Venus in vitro construct - coding region fusion 0 Yes jagnT:Avic\GFP in vitro construct - coding region fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3R)Exel6145 (Ryder, 2004.4.26) Df(3R)Tpl10 (Lee and Cooley, 2007)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD4632} NA P{KK107655} NA P{UASp-jagn.L} NA characterization construct P{jagn-GFP.L} NA P{jagn-Venus.L} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EP}jagnG4067 NA
Gene Ontology: Function, Process & Cellular Component ( 11 unique terms )
	There is no information supporting a molecular function term for this gene. (Based on a review of available data on: 2008-03-20)
Terms Based on Experimental Evidence ( 8 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
chaeta development inferred from mutant phenotype (assigned by UniProtKB) (Lee and Cooley, 2007) chaeta morphogenesis inferred from mutant phenotype (Lee and Cooley, 2007) endoplasmic reticulum organization inferred from mutant phenotype (assigned by UniProtKB) (Lee and Cooley, 2007) establishment of ER localization inferred from mutant phenotype (Lee and Cooley, 2007) exocytosis inferred from mutant phenotype (assigned by UniProtKB) (Lee and Cooley, 2007) oocyte growth inferred from mutant phenotype (assigned by UniProtKB) (Lee and Cooley, 2007) vitellogenesis inferred from mutant phenotype (Lee and Cooley, 2007)
Cellular Component
CV term Evidence References
endoplasmic reticulum membrane inferred from direct assay (Lee and Cooley, 2007)
Terms Based on Predictions or Assertions ( 3 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
cytoplasmic transport, nurse cell to oocyte non-traceable author statement (Lee and Cooley, 2004) microtubule-based movement non-traceable author statement (Lee and Cooley, 2004) oogenesis non-traceable author statement (Lee and Cooley, 2004)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions jagn allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 65919 DroID - A comprehensive database of gene and protein interactions. • FBgn0037374 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 40714
Orthologs
Genome-wide drosophilid orthologs	Dana\GF16348 Dere\GG13023 Dgri\GH18154 Dmoj\GI10107 Dper\GL24521 Dpse\GA10683 Dsec\GM10838 Dsim\GD19818 Dvir\GJ23328 Dwil\GK13429 Dyak\GE10162
Curated drosophilid orthologs	Dpse\GA10683   Dyak\GE10162
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AGAP003240-PA Anopheles gambiae (mosquito) XP_625084.1 Apis mellifera (honey bee) XP_001950921.1 Acyrthosiphon pisum (pea aphid) 83721 Branchiostoma floridae (lancelet) XP_001892691.1 Brugia malayi (roundworm nematode) BGIBMGA010032-PA Bombyx mori (silk worm) ENSBTAP00000030786 Bos taurus (bovine) CN21377 Caenorhabditis brenneri (small nematode) CBP33289 Caenorhabditis briggsae (nematode) CE19970 Caenorhabditis elegans (worm) ENSCAFP00000007870 Canis familiaris (dog) ENSCINP00000022448 Ciona intestinalis (sea squirt) JA13296 Caenorhabditis japonica (nematode) CPIJ001349 Culex pipens (mosquito) ENSCPOP00000018260 Cavia porcellus (guinea pig) RP02667 Caenorhabditis remanei (nematode) 154162 Capitella spl (polychaete worm) 303901 Daphnia pulex (daphnia) ENSDARP00000060173 Danio rerio (zebra fish) ENSECAP00000014088 Equus caballus (horse) ENSGACP00000018832 Gymnopilus aculeatus (mushroom) ENSGACP00000018961 Gymnopilus aculeatus (mushroom) 74654 Hypsipyla robusta (cedar shoot borer) ENSP00000306106 Homo sapiens (human) ISCW002504-PA Ixodes scapularis (deer tick) 216100 Lottia gigantea (owl limpet) ENSMODP00000006448 Monodelphis domestica (gray opossum) ENSMMUP00000024031 Macaca mulatta (rhesus monkey) ENSMUSP00000098631 Mus musculus (house mouse) 247702 Nematostella vectensis (starlet anemone) XP_001604864.1 Nasonia vitripennis (wasp) ENSOANP00000007063 Ornithorynchus anatinus (platypus) ENSORLP00000004093 Oryzias latipes (japanese killifish) PHUM000083-PA Pediculus humanus (human body louse) PP10998 Pristionchus pacificus (nematode) ENSPPYP00000015288 Pongo pygmaeus (orangutan) 594669 Populus trichocarpa (black cottonwood) ENSPTRP00000025187 Pan troglodytes (chimpanzee) ENSRNOP00000053385 Rattus norvegicus (norway rat) Smp_060270 Schistosoma mansoni (trematode parasite) XP_001814337.1 Tribolium castaneum (red flour beetle) ENSTNIP00000013167 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000031773 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000020055 Xenopus tropicalis (frog) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB18379 NV16119 LH19954 ISCW002504 FBgn0068493 FBgn0215437 FBgn0210429 FBgn0191307 FBgn0165784 JGI_V11_303901 FBgn0070739 FBgn0162110 FBgn0132873 FBgn0125622 FBgn0105296 FBgn0093369 CPIJ001349 BGIBMGA010032 ACYPI007788 GB14796 AGAP003240 AAEL017064 PHUM155360 PHUM589040 GLEAN_14219
Stocks & Reagents
Stocks Listed in FlyBase ( 1 )
Bloomington	30060 w1118; P{EP}jagnG4067 CG2082G4067/TM6C, Sb1
Genomic Clones ( 1 )
	BACR02L23 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 86 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD38087
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT13814 AT14843 AT18439 GH12534 GM05214 GM07462 GM14852 HL02843 LD01841 LD02586 LD10014 LD31037 LD32833 LD42651 LP15378 RE07346 RE26314 RE26984 RE29019 RE29064 RE32587 RE34317 RE36382 RE37766 RE45594 RE48392 RE60016 RE69942 RE71602 RE73717 SD16849 SD19022 SD21349
Other clones	44123 55077 57917 62994 71603 74983 78732 83439 98952 107194 214255.61 214567.64 bs68d03 CK01.18D.C6 Dmel_dig_012403_0590_1924 EK017833 EK063148 EK159737 EK165809 EK182837 EK188663 EK199718 EK207017 EK208128 EK217647 EK227911 EK232937 EP04528 EP09608 EP11418 IP03866 IP13588 RE01174 RE01994 RP001003517 RP001008665 RP001011253 RP001013241 RP001014948 RP001017203 RP001018916 RP001020891 RP001031836 RP001032879 RP001033689 RP001039574 RP001046280 RP001050929 RP001053006 RP001053558 RP001053779 RP001055907
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0037374 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 40714
Antibody Information
Other Information
Discoverer
Etymology
	"jagunal" means small egg in Korean. (Lee, 2004.2.26) The gene is named "jagunal", which means "small egg" in Korean, as mutations in the gene severely affect oocyte growth. (Lee and Cooley, 2007)
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: jagn CG10978 (Lee, 2004.2.26)
Source for database merge of
Additional comments
Other Comments
	jagn is required for reorganising the endoplasmic reticulum (ER) through ER clustering in the oocyte during vitellogenesis. jagn is also required for bristle growth. (Lee and Cooley, 2007) Identification: In a study of lethal mutations that in germ line clones cause a defect in nurse cell cytoplasm transport during oogenesis. (Lee and Cooley, 2004) Oocyte integrity during rapid cytoplasm transport requires jagn. (Lee and Cooley, 2004) jagn causes a defect in the oocyte structure after stage 10. The anterior region of mutant oocytes becomes detached from adjacent nurse cells and follicle cells. The phenotype begins to appear during stage 10 and becomes severe as the oocyte begins to grow rapidly during stage 11, resulting in small eggs. In jagn mutant oocytes, the movement of anterior cytoplasm is defective in stage 10A and jagn ooplasm fails to shift direction to form a whirlpool during stage 10B. exu-containing particle movement is defective in the jagn germline clones. Both macrochaetes and microchaetes formed in jagn clones are short and thin. The jagn macrochaetes are structurally unstable and easily detached. Clones of jagn mutation also cause defects in eye development and follicle cell morphogenesis. (Lee and Cooley, 2004)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_141328 NM_169103 RefSeq (Proteins) • NP_649585 NP_731002 DDBJ / EMBL / GenBank • AAF51956 AAL28991 AAN14321 AI518543 AW943409 AY061443 Entrez Gene - A searchable database of RefSeq genes. • 40714 UniProtKB/TrEMBL • E2QD00 Q7K1V5
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Protein of unknown function DUF1352 (IPR009787)
Linkouts
	BioGRID - A database of protein and genetic interactions • 65919 DroID - A comprehensive database of gene and protein interactions. • FBgn0037374 DRSC - Results from RNAi screens. • FBgn0037374 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0037374 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG10978-RA;CG10978-RB FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0037374 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 40714 InParanoid A subset of ortholog calls from InParanoid. • AGAP003240-PA Anopheles gambiae (mosquito) XP_625084.1 Apis mellifera (honey bee) XP_001950921.1 Acyrthosiphon pisum (pea aphid) 83721 Branchiostoma floridae (lancelet) XP_001892691.1 Brugia malayi (roundworm nematode) BGIBMGA010032-PA Bombyx mori (silk worm) ENSBTAP00000030786 Bos taurus (bovine) CN21377 Caenorhabditis brenneri (small nematode) CBP33289 Caenorhabditis briggsae (nematode) CE19970 Caenorhabditis elegans (worm) ENSCAFP00000007870 Canis familiaris (dog) ENSCINP00000022448 Ciona intestinalis (sea squirt) JA13296 Caenorhabditis japonica (nematode) CPIJ001349 Culex pipens (mosquito) ENSCPOP00000018260 Cavia porcellus (guinea pig) RP02667 Caenorhabditis remanei (nematode) 154162 Capitella spl (polychaete worm) 303901 Daphnia pulex (daphnia) ENSDARP00000060173 Danio rerio (zebra fish) ENSECAP00000014088 Equus caballus (horse) ENSGACP00000018832 Gymnopilus aculeatus (mushroom) ENSGACP00000018961 Gymnopilus aculeatus (mushroom) 74654 Hypsipyla robusta (cedar shoot borer) ENSP00000306106 Homo sapiens (human) ISCW002504-PA Ixodes scapularis (deer tick) 216100 Lottia gigantea (owl limpet) ENSMODP00000006448 Monodelphis domestica (gray opossum) ENSMMUP00000024031 Macaca mulatta (rhesus monkey) ENSMUSP00000098631 Mus musculus (house mouse) 247702 Nematostella vectensis (starlet anemone) XP_001604864.1 Nasonia vitripennis (wasp) ENSOANP00000007063 Ornithorynchus anatinus (platypus) ENSORLP00000004093 Oryzias latipes (japanese killifish) PHUM000083-PA Pediculus humanus (human body louse) PP10998 Pristionchus pacificus (nematode) ENSPPYP00000015288 Pongo pygmaeus (orangutan) 594669 Populus trichocarpa (black cottonwood) ENSPTRP00000025187 Pan troglodytes (chimpanzee) ENSRNOP00000053385 Rattus norvegicus (norway rat) Smp_060270 Schistosoma mansoni (trematode parasite) XP_001814337.1 Tribolium castaneum (red flour beetle) ENSTNIP00000013167 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000031773 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000020055 Xenopus tropicalis (frog) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 40714 modMine - Data generated by the modENCODE project. • FBgn0037374 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB18379 NV16119 LH19954 ISCW002504 FBgn0068493 FBgn0215437 FBgn0210429 FBgn0191307 FBgn0165784 JGI_V11_303901 FBgn0070739 FBgn0162110 FBgn0132873 FBgn0125622 FBgn0105296 FBgn0093369 CPIJ001349 BGIBMGA010032 ACYPI007788 GB14796 AGAP003240 AAEL017064 PHUM155360 PHUM589040 GLEAN_14219
Synonyms & Secondary IDs ( 3 )
Reported As
Symbol Synonym	CG10978 (Hollien and Weissman, 2006, Lee and Cooley, 2007, Keleman et al., 2009.8.5, Cammarato et al., 2011) jagn (Hollien and Weissman, 2006, Hollien and Weissman, 2006, Lee and Cooley, 2007, Xi et al., 2008)
Name Synonym	jagunal (Lee and Cooley, 2004, Lee and Cooley, 2007, Cammarato et al., 2011)
Secondary FlyBase IDs
References ( 17 )
Research paper	Xi et al., 2008, BMC Genomics 9: 1 Genome-wide analysis of the interaction between the endosymbiotic bacterium Wolbachia and its Drosophila host. [FBrf0205106] Lee and Cooley, 2007, J. Cell Biol. 176(7): 941--952 Jagunal is required for reorganizing the endoplasmic reticulum during Drosophila oogenesis. [FBrf0201898] Hollien and Weissman, 2006, Science 313(5783): 104--107 Decay of endoplasmic reticulum-localized mRNAs during the unfolded protein response. [FBrf0192887]
Supplementary material	Cammarato et al., 2011, PLoS ONE 6(4): Table S1. Proteins & Peptides. [FBrf0214682] The modENCODE Consortium, 2010, Science 330(6012): DataS14: Gene co-expression clusters. [FBrf0213979] Dietzl et al., 2007, Nature 448(7150): Supplementary Table 1. [FBrf0202579] Hollien and Weissman, 2006, Science 313(5783): [FBrf0199122] Giot et al., 2003, Science 302(5651): Tables S1 to S7. [FBrf0166452]
Personal communication to FlyBase	Bellen, 2010.2.4, BDGP_2010_0204.GenExel.xml BDGP_2010_0204.GenExel.xml [FBrf0209886] Keleman et al., 2009.8.5, RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0208510] Lee, 2004.2.26, Helping FlyBase: ADRC-10673. Helping FlyBase: ADRC-10673. [FBrf0178798] Ryder, 2004.4.26, Exelixis CG deletion data. Exelixis CG deletion data. [FBrf0184335]
Abstract	Lee and Cooley, 2006, A. Dros. Res. Conf. 47: 87 Jagunal is required for polarized secretion during Drosophila oogenesis. [FBrf0189311] Lee and Cooley, 2004, A. Dros. Res. Conf. 45: 567C Oocyte integrity during rapid cytoplasm transport requires jagunal. [FBrf0173963]
FlyBase analysis	FlyBase Curators, 2002-, Use of the ND evidence code for Gene Ontology (GO) terms in FlyBase. Use of the ND evidence code for Gene Ontology (GO) terms in FlyBase. [FBrf0159398]
Computer file	BDGP Project Members, 2000-, Berkeley Drosophila Genome Project. Berkeley Drosophila Genome Project. [FBrf0125078]