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Gene Dmel\Zif

General Information
Symbol	Dmel\Zif	Species	D. melanogaster
Name	Zinc-finger protein	Annotation symbol	CG10267
Feature type	protein_coding_gene	FlyBase ID	FBgn0037446
Gene Model Status	Current	Stock availability	7 publicly available
Genomic Location
Chromosome (arm)	3R	Recombination map
Cytogenetic map	83E8-83E8	Sequence location	3R:2,282,810..2,284,544 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Zinc-finger protein is referred to in FlyBase by the symbol Dmel\Zif (CG10267, FBgn0037446). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: DNA binding. There is experimental evidence that it is involved in the biological process: establishment or maintenance of neuroblast polarity; neuroblast proliferation. 10 alleles are reported. No phenotypic data is available. It has 3 annotated transcripts and 3 annotated polypeptides. Protein features are: Zinc finger C2H2-type/integrase DNA-binding domain; Zinc finger, AD-type; Zinc finger, C2H2; Zinc finger, C2H2-like. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-12 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult eye, larval/adult central nervous system, adult crop, larval/adult hindgut, larval/adult Malpighian tubules, larval fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male reproductive system, larval carcass. Comments on Affy2 ProbeSet: ProbeSet 1635205_at completely aligns to an exonic region common to each of the 2 FlyBase-annotated transcript isoforms of CG10267. Gene sequence location is 3R:2282810..2284544.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02	Controlled Vocabulary Terms DNA binding
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 83E8-83E8   Limits computationally determined from genome sequence between P{lacW}casj1C2 and P{PZ}lab01241
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Zif for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.44 Gene model reviewed during 5.47
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Zif-RA FBtr0081728  NM_141400   1463   388 Zif-RB FBtr0302383  NM_001202259   1394   388 Zif-RC FBtr0330191  NM_001275390   1455   388
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Zif-PA   FBpp0081225   45.4   388   5.06     NP_649657   AAF54120 Zif-PB   FBpp0291578   45.4   388   5.06     NP_001189188   ADV37279 Zif-PC   FBpp0303224   45.4   388   5.06     NP_001262319   AGB95702
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Zinc finger, C2H2 (IPR007087) Zinc finger, AD-type (IPR012934) Zinc finger, C2H2-like (IPR015880) Zinc finger C2H2-type/integrase DNA-binding domain (IPR013087)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA246271   AA392444   AA697059   AA735138   AA941165   AA942286   AE014297 AAF54120   AE014297 ADV37279   AE014297 AGB95702   AI133979   AI257273   AI257300   AI515780   AI515852   AI519701   AW942720   AX094267   AY070544 AAL48015   BF494950   BF495878   BF499698   BI170822   BI214110   BI214141   BI232473   BI234156   BI238462   BI240776   BI243572   BI353829   BI585743   BI586055   BI587849   BI612656   BI629476   BP556964   BP556965   CO311358   DN154114   DU708678   EC078743   EC223218   FE862972   FE863013   FE863330   FE863361   FE863416   GH738808   GH739295   GH740656   GH742068   GH743668   GH746596   GH762157   GH762727   GH764676   GH766591   GH768418   GH779176   GH779264   GH779290   GH779310   GH779401
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9VI24
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 3   organism   (Fisher et al., 2012) Comment:maternally deposited embryonic stage 4 -- 6   organism | intense & ubiquitous   (Fisher et al., 2012) embryonic stage 7 -- 8   organism | intense & ubiquitous   (Fisher et al., 2012) embryonic stage 9 -- 10   organism | intense & ubiquitous   (Fisher et al., 2012) embryonic stage 11 -- 12   organism | intense & ubiquitous   (Fisher et al., 2012) embryonic stage 13 -- 16   embryonic brain   (Fisher et al., 2012) embryonic/larval midgut   (Fisher et al., 2012) gonad   (Fisher et al., 2012) organism | ubiquitous   (Fisher et al., 2012) ventral nerve cord   (Fisher et al., 2012)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization Stage Tissue/Position (including subcellular localization) Reference third instar larval stage   ganglion mother cell   (Chang et al., 2010) embryonic/larval neuroblast   (Chang et al., 2010) embryonic/larval brain   (Chang et al., 2010) embryonic/larval neuron   (Chang et al., 2010)
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult eye, larval/adult central nervous system, adult crop, larval/adult hindgut, larval/adult Malpighian tubules, larval fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male reproductive system, larval carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    293.25 Larval Midgut    69.4 Larval Hindgut    104.4 Larval Malpighian Tubules    103.7 Larval Fat Body    114.3 Larval Salivary Gland    192.4 Larval Trachea    177.6 Larval Carcass    106.5 Adult Head    99.1 Adult Eye    147.825 Adult Brain    214.9 Adult Thoracic-Abdominal Ganglion    200.9 Adult Crop    114.7 Adult Midgut    97.5 Adult Hindgut    119.3 Adult Malpighian Tubules    178.5 Adult Fat Body    60.3 Adult Salivary Gland    136.8 Adult Heart    84.175 Adult VirginFemale Spermatheca    114.2 Adult InseminatedFemale Spermatheca    108 Adult Ovary    305.6 Adult Testis    325.1 Adult Male Accessory Gland    108.1 Adult Carcass    79.2 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    293.25 Larval Midgut    69.4 Larval Hindgut    104.4 Larval Malpighian Tubules    103.7 Larval Fat Body    114.3 Larval Salivary Gland    192.4 Larval Trachea    177.6 Larval Carcass    106.5 Adult Head    99.1 Adult Eye    147.825 Adult Brain    214.9 Adult Thoracic-Abdominal Ganglion    200.9 Adult Crop    114.7 Adult Midgut    97.5 Adult Hindgut    119.3 Adult Malpighian Tubules    178.5 Adult Fat Body    60.3 Adult Salivary Gland    136.8 Adult Heart    84.175 Adult VirginFemale Spermatheca    114.2 Adult InseminatedFemale Spermatheca    108 Adult Ovary    305.6 Adult Testis    325.1 Adult Male Accessory Gland    108.1 Adult Carcass    79.2 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    293.25 Larval Midgut    69.4 Larval Hindgut    104.4 Larval Malpighian Tubules    103.7 Larval Fat Body    114.3 Larval Salivary Gland    192.4 Larval Trachea    177.6 Larval Carcass    106.5 Adult Head    99.1 Adult Eye    147.825 Adult Brain    214.9 Adult Thoracic-Abdominal Ganglion    200.9 Adult Crop    114.7 Adult Midgut    97.5 Adult Hindgut    119.3 Adult Malpighian Tubules    178.5 Adult Fat Body    60.3 Adult Salivary Gland    136.8 Adult Heart    84.175 Adult VirginFemale Spermatheca    114.2 Adult InseminatedFemale Spermatheca    108 Adult Ovary    305.6 Adult Testis    325.1 Adult Male Accessory Gland    108.1 Adult Carcass    79.2 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    293.25 Larval Midgut    69.4 Larval Hindgut    104.4 Larval Malpighian Tubules    103.7 Larval Fat Body    114.3 Larval Salivary Gland    192.4 Larval Trachea    177.6 Larval Carcass    106.5 Adult Head    99.1 Adult Eye    147.825 Adult Brain    214.9 Adult Thoracic-Abdominal Ganglion    200.9 Adult Crop    114.7 Adult Midgut    97.5 Adult Hindgut    119.3 Adult Malpighian Tubules    178.5 Adult Fat Body    60.3 Adult Salivary Gland    136.8 Adult Heart    84.175 Adult VirginFemale Spermatheca    114.2 Adult InseminatedFemale Spermatheca    108 Adult Ovary    305.6 Adult Testis    325.1 Adult Male Accessory Gland    108.1 Adult Carcass    79.2 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    293.25 Larval Midgut    69.4 Larval Hindgut    104.4 Larval Malpighian Tubules    103.7 Larval Fat Body    114.3 Larval Salivary Gland    192.4 Larval Trachea    177.6 Larval Carcass    106.5 Adult Head    99.1 Adult Eye    147.825 Adult Brain    214.9 Adult Thoracic-Abdominal Ganglion    200.9 Adult Crop    114.7 Adult Midgut    97.5 Adult Hindgut    119.3 Adult Malpighian Tubules    178.5 Adult Fat Body    60.3 Adult Salivary Gland    136.8 Adult Heart    84.175 Adult VirginFemale Spermatheca    114.2 Adult InseminatedFemale Spermatheca    108 Adult Ovary    305.6 Adult Testis    325.1 Adult Male Accessory Gland    108.1 Adult Carcass    79.2 Expression Level Scale  None   Low   Moderate   High  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    293.25 Larval Midgut    69.4 Larval Hindgut    104.4 Larval Malpighian Tubules    103.7 Larval Fat Body    114.3 Larval Salivary Gland    192.4 Larval Trachea    177.6 Larval Carcass    106.5 Adult Head    99.1 Adult Eye    147.825 Adult Brain    214.9 Adult Thoracic-Abdominal Ganglion    200.9 Adult Crop    114.7 Adult Midgut    97.5 Adult Hindgut    119.3 Adult Malpighian Tubules    178.5 Adult Fat Body    60.3 Adult Salivary Gland    136.8 Adult Heart    84.175 Adult VirginFemale Spermatheca    114.2 Adult InseminatedFemale Spermatheca    108 Adult Ovary    305.6 Adult Testis    325.1 Adult Male Accessory Gland    108.1 Adult Carcass    79.2 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    293.25 Larval Midgut    69.4 Larval Hindgut    104.4 Larval Malpighian Tubules    103.7 Larval Fat Body    114.3 Larval Salivary Gland    192.4 Larval Trachea    177.6 Larval Carcass    106.5 Adult Head    99.1 Adult Eye    147.825 Adult Brain    214.9 Adult Thoracic-Abdominal Ganglion    200.9 Adult Crop    114.7 Adult Midgut    97.5 Adult Hindgut    119.3 Adult Malpighian Tubules    178.5 Adult Fat Body    60.3 Adult Salivary Gland    136.8 Adult Heart    84.175 Adult VirginFemale Spermatheca    114.2 Adult InseminatedFemale Spermatheca    108 Adult Ovary    305.6 Adult Testis    325.1 Adult Male Accessory Gland    108.1 Adult Carcass    79.2 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    293.25 Larval Midgut    69.4 Larval Hindgut    104.4 Larval Malpighian Tubules    103.7 Larval Fat Body    114.3 Larval Salivary Gland    192.4 Larval Trachea    177.6 Larval Carcass    106.5 Adult Head    99.1 Adult Eye    147.825 Adult Brain    214.9 Adult Thoracic-Abdominal Ganglion    200.9 Adult Crop    114.7 Adult Midgut    97.5 Adult Hindgut    119.3 Adult Malpighian Tubules    178.5 Adult Fat Body    60.3 Adult Salivary Gland    136.8 Adult Heart    84.175 Adult VirginFemale Spermatheca    114.2 Adult InseminatedFemale Spermatheca    108 Adult Ovary    305.6 Adult Testis    325.1 Adult Male Accessory Gland    108.1 Adult Carcass    79.2 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    99.1   NA  Eye    147.825   NA  Brain    214.9   293.25  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    200.9   NA  Crop    114.7   69.4  Midgut    97.5   104.4  Hindgut    119.3   103.7  Malpighian Tubules    178.5   114.3  Fat Body    60.3   192.4  Salivary Gland    136.8   NA  Heart    84.175   177.6  Trachea    NA   NA  VirginFemale Spermatheca    114.2   NA  InseminatedFemale Spermatheca    108   NA  Ovary    305.6   NA  Testis    325.1   NA  Male Accessory Gland    108.1   106.5  Carcass    79.2 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    106 central nervous system, larvae L3    71 central nervous system, pupae P8    35 head, virgin 1-day female    23 head, virgin 4-day female    30 head, virgin 20-day female    19 head, mated 1-day female    31 head, mated 4-day female    26 head, mated 20-day female    16 head, mated 1-day male    43 head, mated 4-day male    32 head, mated 20-day male    41 salivary gland, larvae L3 wandering    14 salivary gland, white prepupae    38 digestive system, larvae L3 wandering    33 digestive system, 1-day adult    19 digestive system, 4-day adult    19 digestive system, 20-day adult    21 fat body, larvae L3 wandering    11 fat body, white prepupae    29 fat body, pupae P8    44 carcass, larvae L3 wandering    48 carcass, 1-day adult    15 carcass, 4-day adult    19 carcass, 20-day adult    15 ovary, virgin 4-day female    84 ovary, mated 4-day female    80 testis, mated 4-day male    123 accessory gland, mated 4-day male    24 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (106) central nervous system, larvae L3  (71) central nervous system, pupae P8  (35) head, virgin 1-day female    23 head, virgin 4-day female  (30) head, virgin 20-day female    19 head, mated 1-day female  (31) head, mated 4-day female  26 head, mated 20-day female    16 head, mated 1-day male  (43) head, mated 4-day male  (32) head, mated 20-day male  (41) salivary gland, larvae L3 wandering    14 salivary gland, white prepupae  (38) digestive system, larvae L3 wandering  (33) digestive system, 1-day adult    19 digestive system, 4-day adult    19 digestive system, 20-day adult    21 fat body, larvae L3 wandering    11 fat body, white prepupae  (29) fat body, pupae P8  (44) carcass, larvae L3 wandering  (48) carcass, 1-day adult    15 carcass, 4-day adult    19 carcass, 20-day adult    15 ovary, virgin 4-day female  (84) ovary, mated 4-day female  (80) testis, mated 4-day male  (123) accessory gland, mated 4-day male    24 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering  106 central nervous system, larvae L3    71 central nervous system, pupae P8    35 head, virgin 1-day female    23 head, virgin 4-day female    30 head, virgin 20-day female    19 head, mated 1-day female    31 head, mated 4-day female    26 head, mated 20-day female    16 head, mated 1-day male    43 head, mated 4-day male    32 head, mated 20-day male    41 salivary gland, larvae L3 wandering    14 salivary gland, white prepupae    38 digestive system, larvae L3 wandering    33 digestive system, 1-day adult    19 digestive system, 4-day adult    19 digestive system, 20-day adult    21 fat body, larvae L3 wandering    11 fat body, white prepupae    29 fat body, pupae P8    44 carcass, larvae L3 wandering    48 carcass, 1-day adult    15 carcass, 4-day adult    19 carcass, 20-day adult    15 ovary, virgin 4-day female    84 ovary, mated 4-day female    80 testis, mated 4-day male  (123) accessory gland, mated 4-day male    24 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    106 central nervous system, larvae L3    71 central nervous system, pupae P8    35 head, virgin 1-day female    23 head, virgin 4-day female    30 head, virgin 20-day female    19 head, mated 1-day female    31 head, mated 4-day female    26 head, mated 20-day female    16 head, mated 1-day male    43 head, mated 4-day male    32 head, mated 20-day male    41 salivary gland, larvae L3 wandering    14 salivary gland, white prepupae    38 digestive system, larvae L3 wandering    33 digestive system, 1-day adult    19 digestive system, 4-day adult    19 digestive system, 20-day adult    21 fat body, larvae L3 wandering    11 fat body, white prepupae    29 fat body, pupae P8    44 carcass, larvae L3 wandering    48 carcass, 1-day adult    15 carcass, 4-day adult    19 carcass, 20-day adult    15 ovary, virgin 4-day female    84 ovary, mated 4-day female    80 testis, mated 4-day male    123 accessory gland, mated 4-day male    24 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    106 central nervous system, larvae L3    71 central nervous system, pupae P8    35 head, virgin 1-day female    23 head, virgin 4-day female    30 head, virgin 20-day female    19 head, mated 1-day female    31 head, mated 4-day female    26 head, mated 20-day female    16 head, mated 1-day male    43 head, mated 4-day male    32 head, mated 20-day male    41 salivary gland, larvae L3 wandering    14 salivary gland, white prepupae    38 digestive system, larvae L3 wandering    33 digestive system, 1-day adult    19 digestive system, 4-day adult    19 digestive system, 20-day adult    21 fat body, larvae L3 wandering    11 fat body, white prepupae    29 fat body, pupae P8    44 carcass, larvae L3 wandering    48 carcass, 1-day adult    15 carcass, 4-day adult    19 carcass, 20-day adult    15 ovary, virgin 4-day female    84 ovary, mated 4-day female    80 testis, mated 4-day male    123 accessory gland, mated 4-day male    24 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (106) central nervous system, larvae L3  (71) central nervous system, pupae P8  (35) head, virgin 1-day female    23 head, virgin 4-day female  30 head, virgin 20-day female    19 head, mated 1-day female  31 head, mated 4-day female  26 head, mated 20-day female    16 head, mated 1-day male  (43) head, mated 4-day male  32 head, mated 20-day male  (41) salivary gland, larvae L3 wandering    14 salivary gland, white prepupae  (38) digestive system, larvae L3 wandering  (33) digestive system, 1-day adult    19 digestive system, 4-day adult    19 digestive system, 20-day adult    21 fat body, larvae L3 wandering    11 fat body, white prepupae  29 fat body, pupae P8  (44) carcass, larvae L3 wandering  (48) carcass, 1-day adult    15 carcass, 4-day adult    19 carcass, 20-day adult    15 ovary, virgin 4-day female  (84) ovary, mated 4-day female  (80) testis, mated 4-day male  (123) accessory gland, mated 4-day male    24 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering  106 central nervous system, larvae L3    71 central nervous system, pupae P8    35 head, virgin 1-day female    23 head, virgin 4-day female    30 head, virgin 20-day female    19 head, mated 1-day female    31 head, mated 4-day female    26 head, mated 20-day female    16 head, mated 1-day male    43 head, mated 4-day male    32 head, mated 20-day male    41 salivary gland, larvae L3 wandering    14 salivary gland, white prepupae    38 digestive system, larvae L3 wandering    33 digestive system, 1-day adult    19 digestive system, 4-day adult    19 digestive system, 20-day adult    21 fat body, larvae L3 wandering    11 fat body, white prepupae    29 fat body, pupae P8    44 carcass, larvae L3 wandering    48 carcass, 1-day adult    15 carcass, 4-day adult    19 carcass, 20-day adult    15 ovary, virgin 4-day female    84 ovary, mated 4-day female    80 testis, mated 4-day male  123 accessory gland, mated 4-day male    24 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    106 central nervous system, larvae L3    71 central nervous system, pupae P8    35 head, virgin 1-day female    23 head, virgin 4-day female    30 head, virgin 20-day female    19 head, mated 1-day female    31 head, mated 4-day female    26 head, mated 20-day female    16 head, mated 1-day male    43 head, mated 4-day male    32 head, mated 20-day male    41 salivary gland, larvae L3 wandering    14 salivary gland, white prepupae    38 digestive system, larvae L3 wandering    33 digestive system, 1-day adult    19 digestive system, 4-day adult    19 digestive system, 20-day adult    21 fat body, larvae L3 wandering    11 fat body, white prepupae    29 fat body, pupae P8    44 carcass, larvae L3 wandering    48 carcass, 1-day adult    15 carcass, 4-day adult    19 carcass, 20-day adult    15 ovary, virgin 4-day female    84 ovary, mated 4-day female    80 testis, mated 4-day male    123 accessory gland, mated 4-day male    24 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-12 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    69 embryo 02-04hr    92 embryo 04-06hr    95 embryo 06-08hr    90 embryo 08-10hr    89 embryo 10-12hr    62 embryo 12-14hr    48 embryo 14-16hr    45 embryo 16-18hr    41 embryo 18-20hr    31 embryo 20-22hr    46 embryo 22-24hr    44 larva L1    24 larva L2    16 larva L3 12hr old    13 larva L3 puffstage 1-2    17 larva L3 puffstage 3-6    22 larva L3 puffstage 7-9    29 white prepupae new    29 white prepupae 12hr    36 white prepupae 24hr    42 pupae 2d postWPP    34 pupae 3d postWPP    23 pupae 4d postWPP    22 adult male 01day    24 adult male 05day    28 adult male 30day    32 adult female 01day    24 adult female 05day    29 adult female 30day    31 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (69) embryo 02-04hr  (92) embryo 04-06hr  (95) embryo 06-08hr  (90) embryo 08-10hr  (89) embryo 10-12hr  (62) embryo 12-14hr  (48) embryo 14-16hr  (45) embryo 16-18hr  (41) embryo 18-20hr  (31) embryo 20-22hr  (46) embryo 22-24hr  (44) larva L1    24 larva L2    16 larva L3 12hr old    13 larva L3 puffstage 1-2    17 larva L3 puffstage 3-6    22 larva L3 puffstage 7-9  (29) white prepupae new  (29) white prepupae 12hr  (36) white prepupae 24hr  (42) pupae 2d postWPP  (34) pupae 3d postWPP    23 pupae 4d postWPP    22 adult male 01day    24 adult male 05day  (28) adult male 30day  (32) adult female 01day    24 adult female 05day  (29) adult female 30day  (31) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    69 embryo 02-04hr    92 embryo 04-06hr    95 embryo 06-08hr    90 embryo 08-10hr    89 embryo 10-12hr    62 embryo 12-14hr    48 embryo 14-16hr    45 embryo 16-18hr    41 embryo 18-20hr    31 embryo 20-22hr    46 embryo 22-24hr    44 larva L1    24 larva L2    16 larva L3 12hr old    13 larva L3 puffstage 1-2    17 larva L3 puffstage 3-6    22 larva L3 puffstage 7-9    29 white prepupae new    29 white prepupae 12hr    36 white prepupae 24hr    42 pupae 2d postWPP    34 pupae 3d postWPP    23 pupae 4d postWPP    22 adult male 01day    24 adult male 05day    28 adult male 30day    32 adult female 01day    24 adult female 05day    29 adult female 30day    31 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    69 embryo 02-04hr    92 embryo 04-06hr    95 embryo 06-08hr    90 embryo 08-10hr    89 embryo 10-12hr    62 embryo 12-14hr    48 embryo 14-16hr    45 embryo 16-18hr    41 embryo 18-20hr    31 embryo 20-22hr    46 embryo 22-24hr    44 larva L1    24 larva L2    16 larva L3 12hr old    13 larva L3 puffstage 1-2    17 larva L3 puffstage 3-6    22 larva L3 puffstage 7-9    29 white prepupae new    29 white prepupae 12hr    36 white prepupae 24hr    42 pupae 2d postWPP    34 pupae 3d postWPP    23 pupae 4d postWPP    22 adult male 01day    24 adult male 05day    28 adult male 30day    32 adult female 01day    24 adult female 05day    29 adult female 30day    31 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    69 embryo 02-04hr    92 embryo 04-06hr    95 embryo 06-08hr    90 embryo 08-10hr    89 embryo 10-12hr    62 embryo 12-14hr    48 embryo 14-16hr    45 embryo 16-18hr    41 embryo 18-20hr    31 embryo 20-22hr    46 embryo 22-24hr    44 larva L1    24 larva L2    16 larva L3 12hr old    13 larva L3 puffstage 1-2    17 larva L3 puffstage 3-6    22 larva L3 puffstage 7-9    29 white prepupae new    29 white prepupae 12hr    36 white prepupae 24hr    42 pupae 2d postWPP    34 pupae 3d postWPP    23 pupae 4d postWPP    22 adult male 01day    24 adult male 05day    28 adult male 30day    32 adult female 01day    24 adult female 05day    29 adult female 30day    31 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (69) embryo 02-04hr  (92) embryo 04-06hr  (95) embryo 06-08hr  (90) embryo 08-10hr  (89) embryo 10-12hr  (62) embryo 12-14hr  (48) embryo 14-16hr  (45) embryo 16-18hr  (41) embryo 18-20hr  31 embryo 20-22hr  (46) embryo 22-24hr  (44) larva L1    24 larva L2    16 larva L3 12hr old    13 larva L3 puffstage 1-2    17 larva L3 puffstage 3-6    22 larva L3 puffstage 7-9  29 white prepupae new  29 white prepupae 12hr  (36) white prepupae 24hr  (42) pupae 2d postWPP  (34) pupae 3d postWPP    23 pupae 4d postWPP    22 adult male 01day    24 adult male 05day  28 adult male 30day  32 adult female 01day    24 adult female 05day  29 adult female 30day  31 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    69 embryo 02-04hr    92 embryo 04-06hr    95 embryo 06-08hr    90 embryo 08-10hr    89 embryo 10-12hr    62 embryo 12-14hr    48 embryo 14-16hr    45 embryo 16-18hr    41 embryo 18-20hr    31 embryo 20-22hr    46 embryo 22-24hr    44 larva L1    24 larva L2    16 larva L3 12hr old    13 larva L3 puffstage 1-2    17 larva L3 puffstage 3-6    22 larva L3 puffstage 7-9    29 white prepupae new    29 white prepupae 12hr    36 white prepupae 24hr    42 pupae 2d postWPP    34 pupae 3d postWPP    23 pupae 4d postWPP    22 adult male 01day    24 adult male 05day    28 adult male 30day    32 adult female 01day    24 adult female 05day    29 adult female 30day    31 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    69 embryo 02-04hr    92 embryo 04-06hr    95 embryo 06-08hr    90 embryo 08-10hr    89 embryo 10-12hr    62 embryo 12-14hr    48 embryo 14-16hr    45 embryo 16-18hr    41 embryo 18-20hr    31 embryo 20-22hr    46 embryo 22-24hr    44 larva L1    24 larva L2    16 larva L3 12hr old    13 larva L3 puffstage 1-2    17 larva L3 puffstage 3-6    22 larva L3 puffstage 7-9    29 white prepupae new    29 white prepupae 12hr    36 white prepupae 24hr    42 pupae 2d postWPP    34 pupae 3d postWPP    23 pupae 4d postWPP    22 adult male 01day    24 adult male 05day    28 adult male 30day    32 adult female 01day    24 adult female 05day    29 adult female 30day    31 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    100 Schneider line 2 Sg4    42 embryonic 1182-4H    71 embryonic GM2    50 embryonic Kc167    49 embryonic S1    104 embryonic S3    51 leg disc CME L1    62 wing disc CME-W2    23 wing disc ML-DmD8    38 wing disc ML-DmD9    78 wing disc ML-DmD16-c3    84 wing disc ML-DmD21    90 wing disc ML-DmD32    57 haltere disc ML-DmD17-c3    64 eye-antennal disc ML-DmD11    51 antennal disc ML-DmD20-c5    61 mixed discs ML-DmD4-c1    70 CNS ML-DmBG1-c1    87 CNS ML-DmBG2-c2    42 tumorous blood cells mbn2    47 ovary fGS/OSS    115 ovary OSC    66 ovary OSS    46 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (100) Schneider line 2 Sg4  (42) embryonic 1182-4H  (71) embryonic GM2  (50) embryonic Kc167  (49) embryonic S1  (104) embryonic S3  (51) leg disc CME L1  (62) wing disc CME-W2    23 wing disc ML-DmD8  (38) wing disc ML-DmD9  (78) wing disc ML-DmD16-c3  (84) wing disc ML-DmD21  (90) wing disc ML-DmD32  (57) haltere disc ML-DmD17-c3  (64) eye-antennal disc ML-DmD11  (51) antennal disc ML-DmD20-c5  (61) mixed discs ML-DmD4-c1  (70) CNS ML-DmBG1-c1  (87) CNS ML-DmBG2-c2  (42) tumorous blood cells mbn2  (47) ovary fGS/OSS  (115) ovary OSC  (66) ovary OSS  (46) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    100 Schneider line 2 Sg4    42 embryonic 1182-4H    71 embryonic GM2    50 embryonic Kc167    49 embryonic S1  104 embryonic S3    51 leg disc CME L1    62 wing disc CME-W2    23 wing disc ML-DmD8    38 wing disc ML-DmD9    78 wing disc ML-DmD16-c3    84 wing disc ML-DmD21    90 wing disc ML-DmD32    57 haltere disc ML-DmD17-c3    64 eye-antennal disc ML-DmD11    51 antennal disc ML-DmD20-c5    61 mixed discs ML-DmD4-c1    70 CNS ML-DmBG1-c1    87 CNS ML-DmBG2-c2    42 tumorous blood cells mbn2    47 ovary fGS/OSS  (115) ovary OSC    66 ovary OSS    46 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    100 Schneider line 2 Sg4    42 embryonic 1182-4H    71 embryonic GM2    50 embryonic Kc167    49 embryonic S1    104 embryonic S3    51 leg disc CME L1    62 wing disc CME-W2    23 wing disc ML-DmD8    38 wing disc ML-DmD9    78 wing disc ML-DmD16-c3    84 wing disc ML-DmD21    90 wing disc ML-DmD32    57 haltere disc ML-DmD17-c3    64 eye-antennal disc ML-DmD11    51 antennal disc ML-DmD20-c5    61 mixed discs ML-DmD4-c1    70 CNS ML-DmBG1-c1    87 CNS ML-DmBG2-c2    42 tumorous blood cells mbn2    47 ovary fGS/OSS    115 ovary OSC    66 ovary OSS    46 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    100 Schneider line 2 Sg4    42 embryonic 1182-4H    71 embryonic GM2    50 embryonic Kc167    49 embryonic S1    104 embryonic S3    51 leg disc CME L1    62 wing disc CME-W2    23 wing disc ML-DmD8    38 wing disc ML-DmD9    78 wing disc ML-DmD16-c3    84 wing disc ML-DmD21    90 wing disc ML-DmD32    57 haltere disc ML-DmD17-c3    64 eye-antennal disc ML-DmD11    51 antennal disc ML-DmD20-c5    61 mixed discs ML-DmD4-c1    70 CNS ML-DmBG1-c1    87 CNS ML-DmBG2-c2    42 tumorous blood cells mbn2    47 ovary fGS/OSS    115 ovary OSC    66 ovary OSS    46 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (100) Schneider line 2 Sg4  (42) embryonic 1182-4H  (71) embryonic GM2  (50) embryonic Kc167  (49) embryonic S1  (104) embryonic S3  (51) leg disc CME L1  (62) wing disc CME-W2    23 wing disc ML-DmD8  (38) wing disc ML-DmD9  (78) wing disc ML-DmD16-c3  (84) wing disc ML-DmD21  (90) wing disc ML-DmD32  (57) haltere disc ML-DmD17-c3  (64) eye-antennal disc ML-DmD11  (51) antennal disc ML-DmD20-c5  (61) mixed discs ML-DmD4-c1  (70) CNS ML-DmBG1-c1  (87) CNS ML-DmBG2-c2  (42) tumorous blood cells mbn2  (47) ovary fGS/OSS  (115) ovary OSC  (66) ovary OSS  (46) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    100 Schneider line 2 Sg4    42 embryonic 1182-4H    71 embryonic GM2    50 embryonic Kc167    49 embryonic S1  104 embryonic S3    51 leg disc CME L1    62 wing disc CME-W2    23 wing disc ML-DmD8    38 wing disc ML-DmD9    78 wing disc ML-DmD16-c3    84 wing disc ML-DmD21    90 wing disc ML-DmD32    57 haltere disc ML-DmD17-c3    64 eye-antennal disc ML-DmD11    51 antennal disc ML-DmD20-c5    61 mixed discs ML-DmD4-c1    70 CNS ML-DmBG1-c1    87 CNS ML-DmBG2-c2    42 tumorous blood cells mbn2    47 ovary fGS/OSS  115 ovary OSC    66 ovary OSS    46 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    100 Schneider line 2 Sg4    42 embryonic 1182-4H    71 embryonic GM2    50 embryonic Kc167    49 embryonic S1    104 embryonic S3    51 leg disc CME L1    62 wing disc CME-W2    23 wing disc ML-DmD8    38 wing disc ML-DmD9    78 wing disc ML-DmD16-c3    84 wing disc ML-DmD21    90 wing disc ML-DmD32    57 haltere disc ML-DmD17-c3    64 eye-antennal disc ML-DmD11    51 antennal disc ML-DmD20-c5    61 mixed discs ML-DmD4-c1    70 CNS ML-DmBG1-c1    87 CNS ML-DmBG2-c2    42 tumorous blood cells mbn2    47 ovary fGS/OSS    115 ovary OSC    66 ovary OSS    46 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    50 cold shock, 4-day adult    39 heat shock, 4-day adult    37 Cadmium 50 mM 6 hrs, larvae L3    22 Cadmium 50 mM 12 hrs, larvae L3    31 Cadmium 50 mM 48 hrs, 4-day adult    38 Cadmium 100 mM 48 hrs, 4-day adult    70 Copper 0.5 mM 12 hrs, larvae L3    55 Copper 15 mM 48 hrs, 4-day adult    35 Zinc 5 mM 12 hrs, larvae L3    37 Zinc 4.5 mM 48 hrs, 4-day adult    36 Ethanol 2.5% 3 hrs, larvae L3    59 Ethanol 5% 3 hrs, larvae L3    22 Ethanol 10% 3 hrs, larvae L3    22 Caffeine 1.5 mg/ml 4 hrs, larvae L3    13 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    52 Caffeine 25 mg/ml 48 hrs, 4-day adult    42 Paraquat 5 mM 48 hrs, 4-day adult    51 Paraquat 10 mM 48 hrs, 4-day adult    47 Rotenone 2 μg 12 hrs, larvae L3    18 Rotenone 8 μg 12 hrs, larvae L3    24 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (50) cold shock, 4-day adult  (39) heat shock, 4-day adult  (37) Cadmium 50 mM 6 hrs, larvae L3    22 Cadmium 50 mM 12 hrs, larvae L3  (31) Cadmium 50 mM 48 hrs, 4-day adult  (38) Cadmium 100 mM 48 hrs, 4-day adult  (70) Copper 0.5 mM 12 hrs, larvae L3  (55) Copper 15 mM 48 hrs, 4-day adult  (35) Zinc 5 mM 12 hrs, larvae L3  (37) Zinc 4.5 mM 48 hrs, 4-day adult  (36) Ethanol 2.5% 3 hrs, larvae L3  (59) Ethanol 5% 3 hrs, larvae L3    22 Ethanol 10% 3 hrs, larvae L3    22 Caffeine 1.5 mg/ml 4 hrs, larvae L3    13 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (52) Caffeine 25 mg/ml 48 hrs, 4-day adult  (42) Paraquat 5 mM 48 hrs, 4-day adult  (51) Paraquat 10 mM 48 hrs, 4-day adult  (47) Rotenone 2 μg 12 hrs, larvae L3    18 Rotenone 8 μg 12 hrs, larvae L3    24 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    50 cold shock, 4-day adult    39 heat shock, 4-day adult    37 Cadmium 50 mM 6 hrs, larvae L3    22 Cadmium 50 mM 12 hrs, larvae L3    31 Cadmium 50 mM 48 hrs, 4-day adult    38 Cadmium 100 mM 48 hrs, 4-day adult    70 Copper 0.5 mM 12 hrs, larvae L3    55 Copper 15 mM 48 hrs, 4-day adult    35 Zinc 5 mM 12 hrs, larvae L3    37 Zinc 4.5 mM 48 hrs, 4-day adult    36 Ethanol 2.5% 3 hrs, larvae L3    59 Ethanol 5% 3 hrs, larvae L3    22 Ethanol 10% 3 hrs, larvae L3    22 Caffeine 1.5 mg/ml 4 hrs, larvae L3    13 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    52 Caffeine 25 mg/ml 48 hrs, 4-day adult    42 Paraquat 5 mM 48 hrs, 4-day adult    51 Paraquat 10 mM 48 hrs, 4-day adult    47 Rotenone 2 μg 12 hrs, larvae L3    18 Rotenone 8 μg 12 hrs, larvae L3    24 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    50 cold shock, 4-day adult    39 heat shock, 4-day adult    37 Cadmium 50 mM 6 hrs, larvae L3    22 Cadmium 50 mM 12 hrs, larvae L3    31 Cadmium 50 mM 48 hrs, 4-day adult    38 Cadmium 100 mM 48 hrs, 4-day adult    70 Copper 0.5 mM 12 hrs, larvae L3    55 Copper 15 mM 48 hrs, 4-day adult    35 Zinc 5 mM 12 hrs, larvae L3    37 Zinc 4.5 mM 48 hrs, 4-day adult    36 Ethanol 2.5% 3 hrs, larvae L3    59 Ethanol 5% 3 hrs, larvae L3    22 Ethanol 10% 3 hrs, larvae L3    22 Caffeine 1.5 mg/ml 4 hrs, larvae L3    13 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    52 Caffeine 25 mg/ml 48 hrs, 4-day adult    42 Paraquat 5 mM 48 hrs, 4-day adult    51 Paraquat 10 mM 48 hrs, 4-day adult    47 Rotenone 2 μg 12 hrs, larvae L3    18 Rotenone 8 μg 12 hrs, larvae L3    24 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    50 cold shock, 4-day adult    39 heat shock, 4-day adult    37 Cadmium 50 mM 6 hrs, larvae L3    22 Cadmium 50 mM 12 hrs, larvae L3    31 Cadmium 50 mM 48 hrs, 4-day adult    38 Cadmium 100 mM 48 hrs, 4-day adult    70 Copper 0.5 mM 12 hrs, larvae L3    55 Copper 15 mM 48 hrs, 4-day adult    35 Zinc 5 mM 12 hrs, larvae L3    37 Zinc 4.5 mM 48 hrs, 4-day adult    36 Ethanol 2.5% 3 hrs, larvae L3    59 Ethanol 5% 3 hrs, larvae L3    22 Ethanol 10% 3 hrs, larvae L3    22 Caffeine 1.5 mg/ml 4 hrs, larvae L3    13 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    52 Caffeine 25 mg/ml 48 hrs, 4-day adult    42 Paraquat 5 mM 48 hrs, 4-day adult    51 Paraquat 10 mM 48 hrs, 4-day adult    47 Rotenone 2 μg 12 hrs, larvae L3    18 Rotenone 8 μg 12 hrs, larvae L3    24 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (50) cold shock, 4-day adult  (39) heat shock, 4-day adult  (37) Cadmium 50 mM 6 hrs, larvae L3    22 Cadmium 50 mM 12 hrs, larvae L3  31 Cadmium 50 mM 48 hrs, 4-day adult  (38) Cadmium 100 mM 48 hrs, 4-day adult  (70) Copper 0.5 mM 12 hrs, larvae L3  (55) Copper 15 mM 48 hrs, 4-day adult  (35) Zinc 5 mM 12 hrs, larvae L3  (37) Zinc 4.5 mM 48 hrs, 4-day adult  (36) Ethanol 2.5% 3 hrs, larvae L3  (59) Ethanol 5% 3 hrs, larvae L3    22 Ethanol 10% 3 hrs, larvae L3    22 Caffeine 1.5 mg/ml 4 hrs, larvae L3    13 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (52) Caffeine 25 mg/ml 48 hrs, 4-day adult  (42) Paraquat 5 mM 48 hrs, 4-day adult  (51) Paraquat 10 mM 48 hrs, 4-day adult  (47) Rotenone 2 μg 12 hrs, larvae L3    18 Rotenone 8 μg 12 hrs, larvae L3    24 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    50 cold shock, 4-day adult    39 heat shock, 4-day adult    37 Cadmium 50 mM 6 hrs, larvae L3    22 Cadmium 50 mM 12 hrs, larvae L3    31 Cadmium 50 mM 48 hrs, 4-day adult    38 Cadmium 100 mM 48 hrs, 4-day adult    70 Copper 0.5 mM 12 hrs, larvae L3    55 Copper 15 mM 48 hrs, 4-day adult    35 Zinc 5 mM 12 hrs, larvae L3    37 Zinc 4.5 mM 48 hrs, 4-day adult    36 Ethanol 2.5% 3 hrs, larvae L3    59 Ethanol 5% 3 hrs, larvae L3    22 Ethanol 10% 3 hrs, larvae L3    22 Caffeine 1.5 mg/ml 4 hrs, larvae L3    13 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    52 Caffeine 25 mg/ml 48 hrs, 4-day adult    42 Paraquat 5 mM 48 hrs, 4-day adult    51 Paraquat 10 mM 48 hrs, 4-day adult    47 Rotenone 2 μg 12 hrs, larvae L3    18 Rotenone 8 μg 12 hrs, larvae L3    24 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    50 cold shock, 4-day adult    39 heat shock, 4-day adult    37 Cadmium 50 mM 6 hrs, larvae L3    22 Cadmium 50 mM 12 hrs, larvae L3    31 Cadmium 50 mM 48 hrs, 4-day adult    38 Cadmium 100 mM 48 hrs, 4-day adult    70 Copper 0.5 mM 12 hrs, larvae L3    55 Copper 15 mM 48 hrs, 4-day adult    35 Zinc 5 mM 12 hrs, larvae L3    37 Zinc 4.5 mM 48 hrs, 4-day adult    36 Ethanol 2.5% 3 hrs, larvae L3    59 Ethanol 5% 3 hrs, larvae L3    22 Ethanol 10% 3 hrs, larvae L3    22 Caffeine 1.5 mg/ml 4 hrs, larvae L3    13 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    52 Caffeine 25 mg/ml 48 hrs, 4-day adult    42 Paraquat 5 mM 48 hrs, 4-day adult    51 Paraquat 10 mM 48 hrs, 4-day adult    47 Rotenone 2 μg 12 hrs, larvae L3    18 Rotenone 8 μg 12 hrs, larvae L3    24 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_31 mE1_20_mRNA_expression_cluster_03
External Data & Images
Linkouts	BDGP expression data • LD25151 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0037446 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG10267-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for Zif Stages(s) 4-6 Stages(s) 7-8 Stages(s) 9-10 Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal, with Scer\GAL4pnr-MD237 ZifGD12585 lethal | embryonic stage Zif1L15 Zif2L497 Zif2L745 lethal | recessive ZifLA00955 Other Phenotypes Allele neuroanatomy defective | somatic clone Zif1L15 Zif2L497 Zif2L745 Phenotype manifest in Allele neuroblast | somatic clone | supernumerary Zif1L15 Zif2L745 Zif2L497
Classical Alleles ( 5 )
For All Classical Alleles Show
Allele of Zif Class Mutagen Stocks Known lesion ZifLA00955 P-element activity 2 -- ZifUM-8282-3 1 -- Zif1L15 ethyl methanesulfonate 0 Yes Zif2L497 ethyl methanesulfonate 0 Yes Zif2L745 ethyl methanesulfonate 0 Yes
Alleles Carried on Transgenic Constructs ( 5 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Zif Class Mutagen Stocks Known lesion ZifGD12585 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes ZifGL00601 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes ZifJF02524 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes ZifKK105765 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes ZifNIG.10267R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{NIG.10267R} NA P{TRiP.GL00601} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions P{RS3}ZifUM-8282-3 NA P{SUPor-P}KG02747 NA insertion of mobile activating element P{Mae-UAS.6.11}ZifLA00955 NA
Gene Ontology: Function, Process & Cellular Component ( 5 unique terms )
Terms Based on Experimental Evidence ( 3 terms )
Molecular Function
CV term Evidence References
DNA binding inferred from direct assay (Krystel and Ayyanathan, 2013)
Biological Process
CV term Evidence References
establishment or maintenance of neuroblast polarity inferred from direct assay (Chang et al., 2010) neuroblast proliferation inferred from direct assay (Chang et al., 2010)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 2 terms )
Molecular Function
CV term Evidence References
zinc ion binding inferred from electronic annotation with InterPro:IPR007087, InterPro:IPR012934, InterPro:IPR015880 (FlyBase Curators et al., 2004-)
Biological Process ( 0 terms)
Cellular Component
CV term Evidence References
nucleus inferred from electronic annotation with InterPro:IPR012934 (FlyBase Curators et al., 2004-)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
Zif - Arpc1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Zif - Chro anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Zif - RpL35A anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Zif - pzg anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Zif allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 65996 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0037446 DroID - A comprehensive database of gene and protein interactions. • FBgn0037446 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 40795
Orthologs
OrthoDB Orthologs (13) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6PK2TR Dipteran inclusive ortholog search No orthologs identified Insect inclusive ortholog search No orthologs identified Arthropod inclusive ortholog search No orthologs identified Metazoa inclusive ortholog search No orthologs identified
Orthologs in Drosophila Species (EOG6PK2TR)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\Zif     Drosophila simulans   Dsim\GD19876 Y   Drosophila sechellia   Dsec\GM10897 Y   Drosophila erecta   Dere\GG13457 Y   Drosophila erecta   Dere\GG16354     Drosophila yakuba   Dyak\GE10222 Y   Drosophila ananassae   Dana\GF18364 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA10205 Y   Drosophila persimilis   Dper\GL21751 Y   Drosophila willistoni   Dwil\GK13499 Y   Drosophila virilis   Dvir\GJ24609 Y   Drosophila mojavensis   Dmoj\GI23015 Y   Drosophila grimshawi   Dgri\GH19537 Y
Orthologs in non-Drosophila Dipterans (None identified)
No non-Drosophilid orthologies identified
Orthologs in non-Dipteran Insects (None identified)
No non-Dipteran orthologies identified
Orthologs in non-Insect Arthropods (None identified)
No non-Insect Arthropod orthologies identified
Orthologs in non-Arthropod Metazoa (None identified)
No non-Arthropod Metazoa orthologies identified
Human Orthologs (0)
Gene OMIM HGNC
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD19876 Drosophila sechellia Dsec\GM10897 Drosophila erecta Dere\GG13457 Drosophila yakuba Dyak\GE10222 Drosophila ananassae Dana\GF18364 Drosophila pseudoobscura pseudoobscura Dpse\GA10205 Drosophila persimilis Dper\GL21751 Drosophila willistoni Dwil\GK13499 Drosophila virilis Dvir\GJ24609 Drosophila mojavensis Dmoj\GI23015 Drosophila grimshawi Dgri\GH19537
Stocks & Reagents
Stocks Listed in FlyBase ( 7 )
Bloomington	29360 y1 v1; P{TRiP.JF02524}attP2 36641 y1 sc* v1; P{TRiP.GL00601}attP2 22199 y1 w*; P{Mae-UAS.6.11}ZifLA00955/TM3, Sb1 Ser1
Kyoto	124459 w1118; P{RS3}ZifUM-8282-3 120955 y* w*; P{Mae-UAS.6.11}ZifLA00955
VDRC	v100204 P{KK105765}VIE-260B v22836 w1118; P{GD12585}v22836/TM3
Genomic Clones ( 1 )
	BACR32D05 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 54 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD25151
Other clones	DPiM_LD25151
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT03739 AT09539 AT14330 GH11317 GM09022 GM25293 LD01425 LD05140 LD11312 LD26403 LD39384 LD41450 LD41539 LP05585 LP05616 RE12417 RE19821 RE19854 RE28547 RE29809 RE34937 RE37692 RE41250 RH25388 RH25780 RH28739 RH41591 RH58353
Other clones	EK181422 EK224301 FGM306E08 RM06705 RM06905 RM07005 RM07205 RM07305 RP01145 RP001000718 RP001001840 RP001006871 RP001009036 RP001015701 RP001017105 RP001021669 RP001029321 RP001031929 RP001033309 RP001033531 RP001038927 RP001047343 RP001055509 RP001056213
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0037446 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 40795
Antibody Information
	polyclonal (Chang et al., 2010)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: Zif CG10267 (Chang et al., 2010)
Source for database merge of	Source for merge of: CG10267 anon-WO0118547.391 (FlyBase, 1996-)
Additional comments	Source for merge of CG10267 anon-WO0118547.391 was sequence comparison (date:051113). (FlyBase, 1996-)
Other Comments
	Zif represses aPKC transcription. Phosphorylation of Zif by aPKC excludes it from the nucleus, leading to Zif inactivation in neuroblasts. (Chang et al., 2010) Zif functions in both type-I and -II neuroblast lineages to inhibit neuroblast overgrowth. (Chang et al., 2010) Area matching Drosophila EST AA735138 (inverted). (Davies, 2001.3.15)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_141400 NM_001202259 NM_001275390 RefSeq (Proteins) • NP_649657 NP_001189188 NP_001262319 DDBJ / EMBL / GenBank • AA735138 AA941165 AAF54120 AAL48015 ADV37279 AGB95702 AW942720 AX094267 AY070544 DU708678 Entrez Gene - A searchable database of RefSeq genes. • 40795 UniProtKB/TrEMBL • Q9VI24
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Zinc finger, C2H2 (IPR007087) Zinc finger, AD-type (IPR012934) Zinc finger, C2H2-like (IPR015880) Zinc finger C2H2-type/integrase DNA-binding domain (IPR013087) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • LD25151
Linkouts
	BioGRID - A database of protein and genetic interactions • 65996 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0037446 DroID - A comprehensive database of gene and protein interactions. • FBgn0037446 DRSC - Results from RNAi screens. • FBgn0037446 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0037446 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG10267-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0037446 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 40795 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 40795 modMine - Data generated by the modENCODE project. • FBgn0037446
Synonyms & Secondary IDs ( 4 )
Reported As
Symbol Synonym	anon-WO0118547.391   CG10267 (Ni et al., 2011.7.19, Keleman et al., 2009.8.5, Chang et al., 2010, Perkins et al., 2009, Krystel and Ayyanathan, 2013, Japanese National Institute of Genetics, 2012.5.21) Zif (Chang et al., 2010)
Name Synonym	Zinc-finger protein (Chang et al., 2010)
Secondary FlyBase IDs
	FBgn0062045
References ( 25 )
Generate a list of	All references relating to this gene ( 25 )
List References by type	Research paper  ( 3 ) Supplementary material  ( 4 ) Personal communication to FlyBase  ( 9 ) FlyBase analysis  ( 3 ) Stock list  ( 1 ) Patent  ( 1 ) DNA/RNA sequence record  ( 1 ) Website  ( 1 ) Curated genome annotation  ( 2 )
Recent research papers ( 1 )
	Krystel and Ayyanathan, 2013, Gene 512(2): 373--382 Global analysis of target genes of 21 members of the ZAD transcription factor family in Drosophila melanogaster. [FBrf0220103] Show all research papers ...