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Gene Dmel\Neurochondrin

General Information
Symbol	Dmel\Neurochondrin	Species	D. melanogaster
Name	Neurochondrin	Annotation symbol	CG2330
Feature type	protein_coding_gene	FlyBase ID	FBgn0037447
Gene Model Status	Current	Stock availability	1 publicly available
Genomic Location
Chromosome (arm)	3R	Recombination map
Cytogenetic map	83E8-83E8	Sequence location	3R:2,294,134..2,296,739 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Neurochondrin is referred to in FlyBase by the symbol Dmel\Neurochondrin (CG2330, FBgn0037447). It is a protein_coding_gene from Drosophila melanogaster. An electronic pipeline based on InterPro domains suggests that it has the molecular function: binding. The biological processes in which it is involved are not known. 2 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: Armadillo-like helical; Armadillo-type fold; Neurochondrin. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of very low expression. Peak expression observed within 06-18 hour embryonic stages, during late larval stages, during early pupal stages. Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult crop, larval/adult hindgut, adult heart, larval carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, larval/adult midgut, adult male accessory gland, adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1629837_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of Neurochondrin. Gene sequence location is 3R:2294134..2296739.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2011_10
FB2012_01	Sequence features BKN28843 HFA12580
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 83E8-83E8   Limits computationally determined from genome sequence between P{lacW}casj1C2 and P{PZ}lab01241
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Neurochondrin for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	DGC clone LD42676 appears problematic: incomplete CDS
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Neurochondrin-RA FBtr0081729  NM_141401   2606   723
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Neurochondrin-PA   FBpp0081226   81.6   723   5.74     NP_649658   AAF54119
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Neurochondrin (IPR008709) Armadillo-like helical (IPR011989) Armadillo-type fold (IPR016024)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA698009   AE014297 AAF54119   AI516697   AW943621   AY118571 AAM49940   BI162309   BI231909   BI232337   BI238642   BI240587   BI240928   BI243531   BI357211   BI362881   BI362891   BI367861   BI368475   BI369705   BI369897   BI371153   BI372527   BI483547   BI484353   BI485056   BI563793   BI568426   BI573780   BI573781   BI582641   BI582687   BI584164   BI584260   BI584452   BI584668   BI587030   BI587097   BI588491   BI588580   BI592071   BI604907   BI605255   BI607675   BI608378   BI608473   BI608730   BI610051   BI611287   BI612276   BI615218   BI616447   BI621423   BI622659   BI623136   BI623873   BI624846   BI625737   BI626362   BI627715   BI627849   BI629392   BI629631   BI631261   BT033014   CO189750   CO263032   CO288588   CO288984   CO291487   EC196275   EC208153   EC221588   EC230632   EC242636
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9VI25
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 5 of adulthood & male -- day 7 of adulthood & male   spermatozoon   (Wasbrough et al., 2010)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0037447    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0037447 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of very low expression. Peak expression observed within 06-18 hour embryonic stages, during late larval stages, during early pupal stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0037447 expression level Developmental Stage   Expression Level embryo 00-02hr    70 embryo 02-04hr    78 embryo 04-06hr    90 embryo 06-08hr    810 embryo 08-10hr    1474 embryo 10-12hr    12099 embryo 12-14hr    13246 embryo 14-16hr    16671 embryo 16-18hr    10494 embryo 18-20hr    3492 embryo 20-22hr    1291 embryo 22-24hr    1619 larva L1    2883 larva L2    4733 larva L3 12hr old    6801 larva L3 puffstage 1-2    4472 larva L3 puffstage 3-6    6657 larva L3 puffstage 7-9    10926 white prepupae new    10573 white prepupae 12hr    4302 white prepupae 24hr    2554 pupae 2d postWPP    4403 pupae 3d postWPP    6728 pupae 4d postWPP    3802 adult male 01day    3441 adult male 05day    2418 adult male 30day    3225 adult female 01day    2449 adult female 05day    625 adult female 30day    863 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr    70 embryo 02-04hr    78 embryo 04-06hr    90 embryo 06-08hr  (810) embryo 08-10hr  (1474) embryo 10-12hr  (12099) embryo 12-14hr  (13246) embryo 14-16hr  (16671) embryo 16-18hr  (10494) embryo 18-20hr  (3492) embryo 20-22hr  (1291) embryo 22-24hr  (1619) larva L1  (2883) larva L2  (4733) larva L3 12hr old  (6801) larva L3 puffstage 1-2  (4472) larva L3 puffstage 3-6  (6657) larva L3 puffstage 7-9  (10926) white prepupae new  (10573) white prepupae 12hr  (4302) white prepupae 24hr  (2554) pupae 2d postWPP  (4403) pupae 3d postWPP  (6728) pupae 4d postWPP  (3802) adult male 01day  (3441) adult male 05day  (2418) adult male 30day  (3225) adult female 01day  (2449) adult female 05day  (625) adult female 30day  (863) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    70 embryo 02-04hr    78 embryo 04-06hr    90 embryo 06-08hr    810 embryo 08-10hr  1474 embryo 10-12hr  (12099) embryo 12-14hr  (13246) embryo 14-16hr  (16671) embryo 16-18hr  (10494) embryo 18-20hr  (3492) embryo 20-22hr    1291 embryo 22-24hr  (1619) larva L1  (2883) larva L2  (4733) larva L3 12hr old  (6801) larva L3 puffstage 1-2  (4472) larva L3 puffstage 3-6  (6657) larva L3 puffstage 7-9  (10926) white prepupae new  (10573) white prepupae 12hr  (4302) white prepupae 24hr  (2554) pupae 2d postWPP  (4403) pupae 3d postWPP  (6728) pupae 4d postWPP  (3802) adult male 01day  (3441) adult male 05day  (2418) adult male 30day  (3225) adult female 01day  (2449) adult female 05day    625 adult female 30day    863 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    70 embryo 02-04hr    78 embryo 04-06hr    90 embryo 06-08hr    810 embryo 08-10hr    1474 embryo 10-12hr  (12099) embryo 12-14hr  (13246) embryo 14-16hr  (16671) embryo 16-18hr  10494 embryo 18-20hr    3492 embryo 20-22hr    1291 embryo 22-24hr    1619 larva L1    2883 larva L2    4733 larva L3 12hr old    6801 larva L3 puffstage 1-2    4472 larva L3 puffstage 3-6    6657 larva L3 puffstage 7-9  (10926) white prepupae new  10573 white prepupae 12hr    4302 white prepupae 24hr    2554 pupae 2d postWPP    4403 pupae 3d postWPP    6728 pupae 4d postWPP    3802 adult male 01day    3441 adult male 05day    2418 adult male 30day    3225 adult female 01day    2449 adult female 05day    625 adult female 30day    863 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    70 embryo 02-04hr    78 embryo 04-06hr    90 embryo 06-08hr    810 embryo 08-10hr    1474 embryo 10-12hr    12099 embryo 12-14hr    13246 embryo 14-16hr    16671 embryo 16-18hr    10494 embryo 18-20hr    3492 embryo 20-22hr    1291 embryo 22-24hr    1619 larva L1    2883 larva L2    4733 larva L3 12hr old    6801 larva L3 puffstage 1-2    4472 larva L3 puffstage 3-6    6657 larva L3 puffstage 7-9    10926 white prepupae new    10573 white prepupae 12hr    4302 white prepupae 24hr    2554 pupae 2d postWPP    4403 pupae 3d postWPP    6728 pupae 4d postWPP    3802 adult male 01day    3441 adult male 05day    2418 adult male 30day    3225 adult female 01day    2449 adult female 05day    625 adult female 30day    863 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0037447 expression level Developmental Stage   Expression Level embryo 00-02hr    70 embryo 02-04hr    78 embryo 04-06hr    90 embryo 06-08hr    810 embryo 08-10hr    1474 embryo 10-12hr    12099 embryo 12-14hr    13246 embryo 14-16hr    16671 embryo 16-18hr    10494 embryo 18-20hr    3492 embryo 20-22hr    1291 embryo 22-24hr    1619 larva L1    2883 larva L2    4733 larva L3 12hr old    6801 larva L3 puffstage 1-2    4472 larva L3 puffstage 3-6    6657 larva L3 puffstage 7-9    10926 white prepupae new    10573 white prepupae 12hr    4302 white prepupae 24hr    2554 pupae 2d postWPP    4403 pupae 3d postWPP    6728 pupae 4d postWPP    3802 adult male 01day    3441 adult male 05day    2418 adult male 30day    3225 adult female 01day    2449 adult female 05day    625 adult female 30day    863 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr    70 embryo 02-04hr    78 embryo 04-06hr    90 embryo 06-08hr  (810) embryo 08-10hr  (1474) embryo 10-12hr  (12099) embryo 12-14hr  (13246) embryo 14-16hr  (16671) embryo 16-18hr  (10494) embryo 18-20hr  (3492) embryo 20-22hr  (1291) embryo 22-24hr  (1619) larva L1  (2883) larva L2  (4733) larva L3 12hr old  (6801) larva L3 puffstage 1-2  (4472) larva L3 puffstage 3-6  (6657) larva L3 puffstage 7-9  (10926) white prepupae new  (10573) white prepupae 12hr  (4302) white prepupae 24hr  (2554) pupae 2d postWPP  (4403) pupae 3d postWPP  (6728) pupae 4d postWPP  (3802) adult male 01day  (3441) adult male 05day  (2418) adult male 30day  (3225) adult female 01day  (2449) adult female 05day  (625) adult female 30day  (863) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    70 embryo 02-04hr    78 embryo 04-06hr    90 embryo 06-08hr    810 embryo 08-10hr  1474 embryo 10-12hr  (12099) embryo 12-14hr  (13246) embryo 14-16hr  (16671) embryo 16-18hr  (10494) embryo 18-20hr  (3492) embryo 20-22hr    1291 embryo 22-24hr  1619 larva L1  (2883) larva L2  (4733) larva L3 12hr old  (6801) larva L3 puffstage 1-2  (4472) larva L3 puffstage 3-6  (6657) larva L3 puffstage 7-9  (10926) white prepupae new  (10573) white prepupae 12hr  (4302) white prepupae 24hr  (2554) pupae 2d postWPP  (4403) pupae 3d postWPP  (6728) pupae 4d postWPP  (3802) adult male 01day  (3441) adult male 05day  2418 adult male 30day  (3225) adult female 01day  2449 adult female 05day    625 adult female 30day    863 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    70 embryo 02-04hr    78 embryo 04-06hr    90 embryo 06-08hr    810 embryo 08-10hr    1474 embryo 10-12hr  12099 embryo 12-14hr  13246 embryo 14-16hr  16671 embryo 16-18hr  10494 embryo 18-20hr    3492 embryo 20-22hr    1291 embryo 22-24hr    1619 larva L1    2883 larva L2    4733 larva L3 12hr old    6801 larva L3 puffstage 1-2    4472 larva L3 puffstage 3-6    6657 larva L3 puffstage 7-9  10926 white prepupae new  10573 white prepupae 12hr    4302 white prepupae 24hr    2554 pupae 2d postWPP    4403 pupae 3d postWPP    6728 pupae 4d postWPP    3802 adult male 01day    3441 adult male 05day    2418 adult male 30day    3225 adult female 01day    2449 adult female 05day    625 adult female 30day    863 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    70 embryo 02-04hr    78 embryo 04-06hr    90 embryo 06-08hr    810 embryo 08-10hr    1474 embryo 10-12hr    12099 embryo 12-14hr    13246 embryo 14-16hr    16671 embryo 16-18hr    10494 embryo 18-20hr    3492 embryo 20-22hr    1291 embryo 22-24hr    1619 larva L1    2883 larva L2    4733 larva L3 12hr old    6801 larva L3 puffstage 1-2    4472 larva L3 puffstage 3-6    6657 larva L3 puffstage 7-9    10926 white prepupae new    10573 white prepupae 12hr    4302 white prepupae 24hr    2554 pupae 2d postWPP    4403 pupae 3d postWPP    6728 pupae 4d postWPP    3802 adult male 01day    3441 adult male 05day    2418 adult male 30day    3225 adult female 01day    2449 adult female 05day    625 adult female 30day    863 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0037447    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0037447 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult crop, larval/adult hindgut, adult heart, larval carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, larval/adult midgut, adult male accessory gland, adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0037447 expression level Tissue   Expression Level Larval Central Nervous System    15.65 Larval Midgut    270.4 Larval Hindgut    584.5 Larval Malpighian Tubules no informative data Larval Fat Body no informative data Larval Salivary Gland    8.1 Larval Trachea    81.9 Larval Carcass    1752.525 Adult Head    136.9 Adult Eye    34.325 Adult Brain no informative data Adult Thoracic-Abdominal Ganglion no informative data Adult Crop    1535.2 Adult Midgut    138.3 Adult Hindgut    632.4 Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart    724.95 Adult VirginFemale Spermatheca    45.3 Adult InseminatedFemale Spermatheca    64.2 Adult Ovary no informative data Adult Testis    79.3 Adult Male Accessory Gland    149.4 Adult Carcass    354.7 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    15.65 Larval Midgut    270.4 Larval Hindgut  (584.5) Larval Malpighian Tubules no informative data Larval Fat Body no informative data Larval Salivary Gland    8.1 Larval Trachea    81.9 Larval Carcass  (1752.525) Adult Head    136.9 Adult Eye    34.325 Adult Brain no informative data Adult Thoracic-Abdominal Ganglion no informative data Adult Crop  (1535.2) Adult Midgut    138.3 Adult Hindgut  (632.4) Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart  (724.95) Adult VirginFemale Spermatheca    45.3 Adult InseminatedFemale Spermatheca    64.2 Adult Ovary no informative data Adult Testis    79.3 Adult Male Accessory Gland    149.4 Adult Carcass    354.7 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    15.65 Larval Midgut    270.4 Larval Hindgut    584.5 Larval Malpighian Tubules no informative data Larval Fat Body no informative data Larval Salivary Gland    8.1 Larval Trachea    81.9 Larval Carcass  (1752.525) Adult Head    136.9 Adult Eye    34.325 Adult Brain no informative data Adult Thoracic-Abdominal Ganglion no informative data Adult Crop  (1535.2) Adult Midgut    138.3 Adult Hindgut    632.4 Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart    724.95 Adult VirginFemale Spermatheca    45.3 Adult InseminatedFemale Spermatheca    64.2 Adult Ovary no informative data Adult Testis    79.3 Adult Male Accessory Gland    149.4 Adult Carcass    354.7 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    15.65 Larval Midgut    270.4 Larval Hindgut    584.5 Larval Malpighian Tubules no informative data Larval Fat Body no informative data Larval Salivary Gland    8.1 Larval Trachea    81.9 Larval Carcass    1752.525 Adult Head    136.9 Adult Eye    34.325 Adult Brain no informative data Adult Thoracic-Abdominal Ganglion no informative data Adult Crop    1535.2 Adult Midgut    138.3 Adult Hindgut    632.4 Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart    724.95 Adult VirginFemale Spermatheca    45.3 Adult InseminatedFemale Spermatheca    64.2 Adult Ovary no informative data Adult Testis    79.3 Adult Male Accessory Gland    149.4 Adult Carcass    354.7 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0037447 expression level Tissue   Expression Level Larval Central Nervous System    15.65 Larval Midgut    270.4 Larval Hindgut    584.5 Larval Malpighian Tubules no informative data Larval Fat Body no informative data Larval Salivary Gland    8.1 Larval Trachea    81.9 Larval Carcass    1752.525 Adult Head    136.9 Adult Eye    34.325 Adult Brain no informative data Adult Thoracic-Abdominal Ganglion no informative data Adult Crop    1535.2 Adult Midgut    138.3 Adult Hindgut    632.4 Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart    724.95 Adult VirginFemale Spermatheca    45.3 Adult InseminatedFemale Spermatheca    64.2 Adult Ovary no informative data Adult Testis    79.3 Adult Male Accessory Gland    149.4 Adult Carcass    354.7 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    15.65 Larval Midgut    270.4 Larval Hindgut  584.5 Larval Malpighian Tubules no informative data Larval Fat Body no informative data Larval Salivary Gland    8.1 Larval Trachea    81.9 Larval Carcass  (1752.525) Adult Head    136.9 Adult Eye    34.325 Adult Brain no informative data Adult Thoracic-Abdominal Ganglion no informative data Adult Crop  (1535.2) Adult Midgut    138.3 Adult Hindgut  632.4 Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart  724.95 Adult VirginFemale Spermatheca    45.3 Adult InseminatedFemale Spermatheca    64.2 Adult Ovary no informative data Adult Testis    79.3 Adult Male Accessory Gland    149.4 Adult Carcass    354.7 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    15.65 Larval Midgut    270.4 Larval Hindgut    584.5 Larval Malpighian Tubules no informative data Larval Fat Body no informative data Larval Salivary Gland    8.1 Larval Trachea    81.9 Larval Carcass  (1752.525) Adult Head    136.9 Adult Eye    34.325 Adult Brain no informative data Adult Thoracic-Abdominal Ganglion no informative data Adult Crop  1535.2 Adult Midgut    138.3 Adult Hindgut    632.4 Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart    724.95 Adult VirginFemale Spermatheca    45.3 Adult InseminatedFemale Spermatheca    64.2 Adult Ovary no informative data Adult Testis    79.3 Adult Male Accessory Gland    149.4 Adult Carcass    354.7 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    15.65 Larval Midgut    270.4 Larval Hindgut    584.5 Larval Malpighian Tubules no informative data Larval Fat Body no informative data Larval Salivary Gland    8.1 Larval Trachea    81.9 Larval Carcass    1752.525 Adult Head    136.9 Adult Eye    34.325 Adult Brain no informative data Adult Thoracic-Abdominal Ganglion no informative data Adult Crop    1535.2 Adult Midgut    138.3 Adult Hindgut    632.4 Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart    724.95 Adult VirginFemale Spermatheca    45.3 Adult InseminatedFemale Spermatheca    64.2 Adult Ovary no informative data Adult Testis    79.3 Adult Male Accessory Gland    149.4 Adult Carcass    354.7 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules no informative data Larval Fat Body no informative data Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain no informative data Adult Thoracic-Abdominal Ganglion no informative data Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary no informative data Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    136.9   NA  Eye    34.325   NA  Brain    no informative data   15.65  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    no informative data   NA  Crop    1535.2   270.4  Midgut    138.3   584.5  Hindgut    632.4   no informative data  Malpighian Tubules    no informative data   no informative data  Fat Body    no informative data   8.1  Salivary Gland    no informative data   NA  Heart    724.95   81.9  Trachea    NA   NA  VirginFemale Spermatheca    45.3   NA  InseminatedFemale Spermatheca    64.2   NA  Ovary    no informative data   NA  Testis    79.3   NA  Male Accessory Gland    149.4   1752.525  Carcass    354.7 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_25
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0037447 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG2330-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for Neurochondrin Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Phenotype manifest in Allele
Classical Alleles ( 0 )
For All Classical Alleles Show
Allele of Neurochondrin Class Mutagen Stocks Known lesion
Alleles Carried on Transgenic Constructs ( 2 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Neurochondrin Class Mutagen Stocks Known lesion NeurochondrinGD9776 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes NeurochondrinKK108843 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD9776} NA P{KK108843} NA
Insertions
	Type of insertions Name Expression data
Gene Ontology: Function, Process & Cellular Component ( 1 unique term )
	There is no information supporting a biological process or cellular component term for this gene. (Based on a review of available data on: 2008-03-14)
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 1 term )
Molecular Function
CV term Evidence References
binding inferred from electronic annotation with InterPro:IPR011989, InterPro:IPR016024 (FlyBase Curators et al., 2004-)
Biological Process ( 0 terms)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Neurochondrin allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 65997 DroID - A comprehensive database of gene and protein interactions. • FBgn0037447 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 40796
Orthologs
Genome-wide drosophilid orthologs	Dana\GF18365 Dere\GG13468 Dgri\GH15609 Dmoj\GI22483 Dper\GL21752 Dpse\GA15350 Dsec\GM10898 Dsim\GD19877 Dvir\GJ10082 Dwil\GK11575 Dyak\GE10223
Curated drosophilid orthologs	Dpse\GA15350
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • XP_624807.1 Apis mellifera (honey bee) XP_001951656.1 Acyrthosiphon pisum (pea aphid) At4g32050.1 Arabidopsis thaliana (wall cress) 84070 Branchiostoma floridae (lancelet) BGIBMGA005035-PA Bombyx mori (silk worm) ENSBTAP00000048094 Bos taurus (bovine) ENSCAFP00000033313 Canis familiaris (dog) ENSCINP00000021862 Ciona intestinalis (sea squirt) CPIJ008693 Culex pipens (mosquito) ENSCPOP00000014484 Cavia porcellus (guinea pig) 171922 Capitella spl (polychaete worm) DDB0186170 Dictyostelium discoideum (amoeba) 303355 Daphnia pulex (daphnia) ENSECAP00000006985 Equus caballus (horse) ENSGACP00000003490 Gymnopilus aculeatus (mushroom) ENSGALP00000040059 Gallus gallus (chicken) ENSP00000362340 Homo sapiens (human) ISCW001552-PA Ixodes scapularis (deer tick) 238919 Lottia gigantea (owl limpet) ENSMODP00000022326 Monodelphis domestica (gray opossum) ENSMMUP00000026046 Macaca mulatta (rhesus monkey) ENSMUSP00000030637 Mus musculus (house mouse) 106669 Nematostella vectensis (starlet anemone) XP_001606743.1 Nasonia vitripennis (wasp) ENSOANP00000021195 Ornithorynchus anatinus (platypus) ENSORLP00000012212 Oryzias latipes (japanese killifish) LOC_Os02g55530.1 Oryza sativa (asian rice) PHUM001088-PA Pediculus humanus (human body louse) 165585 Physcomitrella patens (moss) ENSPPYP00000001795 Pongo pygmaeus (orangutan) 93470 Phytophthora ramorum (sudden oak death pathogen) 155937 Phytophthora sojae (root rot pathogen) 261229 Populus trichocarpa (black cottonwood) ENSPTRP00000044614 Pan troglodytes (chimpanzee) ENSRNOP00000016229 Rattus norvegicus (norway rat) 5056063 Sorghum bicolor (sorghum) XP_001191669.1 Strongylocentrotus purpuratus (purple sea urchin) XP_975616.1 Tribolium castaneum (red flour beetle) ENSTNIP00000007239 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000022755 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000021296 Xenopus tropicalis (frog) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB18292 NV50540 NV11535 LH19940 ISCW001552 FBgn0228097 FBgn0213586 FBgn0197371 FBgn0191365 FBgn0165844 JGI_V11_303355 FBgn0075369 FBgn0159345 FBgn0145211 FBgn0123080 FBgn0105740 FBgn0095383 CPIJ008693 BGIBMGA005035 ACYPI001069 GB14786 AGAP013338 PHUM458080 GLEAN_08791
Stocks & Reagents
Stocks Listed in FlyBase ( 1 )
VDRC	v46555 w1118; P{GD9776}v46555
Genomic Clones ( 1 )
	BACR32D05 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 63 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD42676
Other clones	RH09294
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	HL03622 RE01664 RE24882 RE28386 RE35147 RE37463 RE37887 RE41192 RE43629 RE47559 RE47571 RE53723 RE54450 RE55972 RE56234 RE57984 RE59517 RE66458 RE67440 RE68324 RH09682 RH12793 RH13025 RH13416 RH14920 RH17473 RH20920 RH20975 RH23144 RH23314 RH23660 RH23923 RH27287 RH27365 RH29832 RH29946 RH34513 RH39870 RH40701 RH44794 RH46401 RH52760 RH54566 RH55224 RH56231 RH58252 RH58529 RH60794 RH64553 RH66220 RH67065 RH69101 RH69313 RH70409 RH70831 RH74780
Other clones	EK045063 EK068932 EK069821 EK079730 EK087132
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0037447 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 40796
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_141401 RefSeq (Proteins) • NP_649658 DDBJ / EMBL / GenBank • AAF54119 AAM49940 AI516697 AW943621 AY118571 BI573780 BI573781 Entrez Gene - A searchable database of RefSeq genes. • 40796 UniProtKB/TrEMBL • Q9VI25
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Neurochondrin (IPR008709) Armadillo-like helical (IPR011989) Armadillo-type fold (IPR016024)
Linkouts
	BioGRID - A database of protein and genetic interactions • 65997 DroID - A comprehensive database of gene and protein interactions. • FBgn0037447 DRSC - Results from RNAi screens. • FBgn0037447 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0037447 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG2330-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0037447 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 40796 InParanoid A subset of ortholog calls from InParanoid. • XP_624807.1 Apis mellifera (honey bee) XP_001951656.1 Acyrthosiphon pisum (pea aphid) At4g32050.1 Arabidopsis thaliana (wall cress) 84070 Branchiostoma floridae (lancelet) BGIBMGA005035-PA Bombyx mori (silk worm) ENSBTAP00000048094 Bos taurus (bovine) ENSCAFP00000033313 Canis familiaris (dog) ENSCINP00000021862 Ciona intestinalis (sea squirt) CPIJ008693 Culex pipens (mosquito) ENSCPOP00000014484 Cavia porcellus (guinea pig) 171922 Capitella spl (polychaete worm) DDB0186170 Dictyostelium discoideum (amoeba) 303355 Daphnia pulex (daphnia) ENSECAP00000006985 Equus caballus (horse) ENSGACP00000003490 Gymnopilus aculeatus (mushroom) ENSGALP00000040059 Gallus gallus (chicken) ENSP00000362340 Homo sapiens (human) ISCW001552-PA Ixodes scapularis (deer tick) 238919 Lottia gigantea (owl limpet) ENSMODP00000022326 Monodelphis domestica (gray opossum) ENSMMUP00000026046 Macaca mulatta (rhesus monkey) ENSMUSP00000030637 Mus musculus (house mouse) 106669 Nematostella vectensis (starlet anemone) XP_001606743.1 Nasonia vitripennis (wasp) ENSOANP00000021195 Ornithorynchus anatinus (platypus) ENSORLP00000012212 Oryzias latipes (japanese killifish) LOC_Os02g55530.1 Oryza sativa (asian rice) PHUM001088-PA Pediculus humanus (human body louse) 165585 Physcomitrella patens (moss) ENSPPYP00000001795 Pongo pygmaeus (orangutan) 93470 Phytophthora ramorum (sudden oak death pathogen) 155937 Phytophthora sojae (root rot pathogen) 261229 Populus trichocarpa (black cottonwood) ENSPTRP00000044614 Pan troglodytes (chimpanzee) ENSRNOP00000016229 Rattus norvegicus (norway rat) 5056063 Sorghum bicolor (sorghum) XP_001191669.1 Strongylocentrotus purpuratus (purple sea urchin) XP_975616.1 Tribolium castaneum (red flour beetle) ENSTNIP00000007239 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000022755 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000021296 Xenopus tropicalis (frog) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 40796 modMine - Data generated by the modENCODE project. • FBgn0037447 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB18292 NV50540 NV11535 LH19940 ISCW001552 FBgn0228097 FBgn0213586 FBgn0197371 FBgn0191365 FBgn0165844 JGI_V11_303355 FBgn0075369 FBgn0159345 FBgn0145211 FBgn0123080 FBgn0105740 FBgn0095383 CPIJ008693 BGIBMGA005035 ACYPI001069 GB14786 AGAP013338 PHUM458080 GLEAN_08791
Synonyms & Secondary IDs ( 3 )
Reported As
Symbol Synonym	CG2330 (Montana and Littleton, 2006, Jakobsen et al., 2007, Jensen et al., 2006, Keleman et al., 2009.8.5, Zeitlinger et al., 2007, Zimmermann et al., 2006, Tomancak et al., 2007) Neurochondrin (Wasbrough et al., 2010)
Name Synonym	CG2330   dNeurochondrin (Montana and Littleton, 2006) Neurochondrin
Secondary FlyBase IDs
References ( 16 )
Research paper	Jakobsen et al., 2007, Genes Dev. 21(19): 2448--2460 Temporal ChIP-on-chip reveals Biniou as a universal regulator of the visceral muscle transcriptional network. [FBrf0201841] Tomancak et al., 2007, Genome Biol. 8(7): R145 Global analysis of patterns of gene expression during Drosophila embryogenesis. [FBrf0205271] Jensen et al., 2006, Insect Molec. Biol. 15(3): 329--339 The effect of a synergistic concentration of a Piper nigrum extract used in conjunction with pyrethrum upon gene expression in Drosophila melanogaster. [FBrf0194463] Montana and Littleton, 2006, J. Biol. Chem. 281(12): 8100--8109 Expression profiling of a hypercontraction-induced myopathy in Drosophila suggests a compensatory cytoskeletal remodeling response. [FBrf0190896] Zimmermann et al., 2006, Dev. Dynamics 235(12): 3387--3395 Mes2, a MADF-containing transcription factor essential for Drosophila development. [FBrf0194335] Hekmat-Scafe et al., 2005, Genetics 169(3): 1477--1493 Seizure suppression by gain-of-function escargot mutations. [FBrf0183998]
Supplementary material	The modENCODE Consortium, 2010, Science 330(6012): DataS14: Gene co-expression clusters. [FBrf0213979] Wasbrough et al., 2010, J. Proteomics 73(11): Supplemental Table 1. Mass spectrometry data. [FBrf0213252] Zeitlinger et al., 2007, Nat. Genet. 39(12): Supplementary Information [FBrf0208880] Giot et al., 2003, Science 302(5651): Tables S1 to S7. [FBrf0166452]
Personal communication to FlyBase	Keleman et al., 2009.8.5, RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0208510] Dickson et al., 2007.7.18, RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0200327] FlyBase Curators et al., 2004-, Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. [FBrf0174215]
FlyBase analysis	FlyBase Curators, 2002-, Use of the ND evidence code for Gene Ontology (GO) terms in FlyBase. Use of the ND evidence code for Gene Ontology (GO) terms in FlyBase. [FBrf0159398] FlyBase, 1992-, FlyBase curation FlyBase curation. [FBrf0105495]
Computer file	BDGP Project Members, 2000-, Berkeley Drosophila Genome Project. Berkeley Drosophila Genome Project. [FBrf0125078]