A Database of Drosophila Genes & Genomes

FB2013_03, released May 7th, 2013
 

Gene Dmel\Ir84a

General Information
SymbolDmel\Ir84aSpeciesD. melanogaster
NameIonotropic receptor 84aAnnotation symbolCG10101
Feature typeprotein_coding_geneFlyBase IDFBgn0037501
Gene Model StatusCurrent Stock availability 6 publicly available
Genomic Location
Chromosome (arm)3RRecombination map
Cytogenetic map84D6-84D6Sequence location3R:3,232,591..3,235,106 [+]

Genomic Maps

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Automatically generated summary

See sections below for more information
The gene Ionotropic receptor 84a is referred to in FlyBase by the symbol Dmel\Ir84a (CG10101, FBgn0037501). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: extracellular phenylacetaldehyde-gated ion channel activity. There is experimental evidence that it is involved in the biological process: detection of chemical stimulus involved in sensory perception of smell; male courtship behavior. 9 alleles are reported. The phenotypes of these alleles are annotated with: trichogen cell; mesothoracic tergum; sensillum coeloconicum of antennal segment 3. It has one annotated transcript and one annotated polypeptide. Protein features are: Ionotropic glutamate receptor. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of extremely low expression to a trough of no expression detected. Peak expression observed within 06-12 and 18-24 hour embryonic stages, at stages throughout the larval period, at stages throughout the pupal period, in stages of adults of both sexes. Summary of FlyAtlas Anatomical Expression Data: No expression detected in any larval or adult organs/tissues. Comments on Affy2 ProbeSet: ProbeSet 1625903_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of Ir84a. Gene sequence location is 3R:3232591..3235106.

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Description
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FB2013_03
FB2013_02
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FlyBase Computed Cytological Location
Cytogenetic map
Evidence for location
84D6-84D6  
Limits computationally determined from genome sequence between P{EP}EP3060EP3060 and P{PZ}grn05930  
Experimentally Determined Cytological Location
Cytogenetic map
Notes
References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
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Please see the GBrowse view of Dmel\Ir84a for information on other features GBrowse View Help
To submit a correction to a gene model please use the Contact FlyBase form
detailed view FBtr0336955 FBpp0307898 FBti0129412
Comments on Gene Model
Gene model reviewed during 5.48
hide Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Associated CDS (aa)
FBtr0336955
  1935
  644
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
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Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank protein
FBpp0307898  
74.4  
644  
7.46  
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences
InterPro domains - A database of protein families, domains, and functional sites
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DDBJ /
EMBL /
GenBank
DNA sequence
Protein sequence
Name
 
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL
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Mapped Features have been reorganized, please see this article for details.
Additional mapped features and mutations can be found on GBrowse or related reports.
Type
Symbol & Location
Additional Notes
References
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Crossreferences
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hideTranscript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
Additional Descriptive Data
Ir84a transcript is observed in the neurons of the antennal coeloconic sensillum ac4. In sensillum ac4 it is co-expressed with Ir76a, Ir75d and Ir76b.
Ir84a transcript is expressed in a subset of the antennal sensilla.
Marker for
Subcellular Localization
CV Term
hide Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term
References
inferred from direct assay
inferred from direct assay
inferred from direct assay
inferred from direct assay
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Associated Tools
Reference
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
hide FlyAtlas Anatomy Microarray

FlyAtlas Anatomical Expression Data

(FlyAtlas-RNA.adult)

(FlyAtlas-RNA.larva)


   Styles
   Scales

Summary of FlyAtlas Anatomical Expression Data: No expression detected in any larval or adult organs/tissues.
[download data (TSV)]

Guide to FlyAtlas expression level colors
 
No expression (0 - 9.999)
 
Low expression (10 - 99.999)
 
Moderate expression (100 - 499.999)
 
High level expression (500 - 999.999)
 
Very high expression (>999.999)

Linear, scaled to maximum expression level
Tissue   Expression Level
Larval Central Nervous System
 
 0.475
Larval Midgut
 
 1.8
Larval Hindgut
 
 0.7
Larval Malpighian Tubules
 
 1.4
Larval Fat Body
 
 1.8
Larval Salivary Gland
 
 2.7
Larval Trachea
 
 0.65
Larval Carcass
 
 2.075
Adult Head
 
 3.6
Adult Eye
 
 0.8
Adult Brain
 
 0.4
Adult Thoracic-Abdominal Ganglion
 
 0.9
Adult Crop
 
 1.5
Adult Midgut
 
 1.5
Adult Hindgut
 
 1.1
Adult Malpighian Tubules
 
 1.4
Adult Fat Body
 
 2.1
Adult Salivary Gland
 
 2.1
Adult Heart
 
 0.975
Adult VirginFemale Spermatheca
 
 0.9
Adult InseminatedFemale Spermatheca
 
 0.6
Adult Ovary
 
 0.4
Adult Testis
 
 3.5
Adult Male Accessory Gland
 
 1.7
Adult Carcass
 
 2.7
Expression Level Scale
 None 
 Low 
Linear, scaled to Moderate expression
Tissue   Expression Level
Larval Central Nervous System
 
 0.475
Larval Midgut
 
 1.8
Larval Hindgut
 
 0.7
Larval Malpighian Tubules
 
 1.4
Larval Fat Body
 
 1.8
Larval Salivary Gland
 
 2.7
Larval Trachea
 
 0.65
Larval Carcass
 
 2.075
Adult Head
 
 3.6
Adult Eye
 
 0.8
Adult Brain
 
 0.4
Adult Thoracic-Abdominal Ganglion
 
 0.9
Adult Crop
 
 1.5
Adult Midgut
 
 1.5
Adult Hindgut
 
 1.1
Adult Malpighian Tubules
 
 1.4
Adult Fat Body
 
 2.1
Adult Salivary Gland
 
 2.1
Adult Heart
 
 0.975
Adult VirginFemale Spermatheca
 
 0.9
Adult InseminatedFemale Spermatheca
 
 0.6
Adult Ovary
 
 0.4
Adult Testis
 
 3.5
Adult Male Accessory Gland
 
 1.7
Adult Carcass
 
 2.7
Expression Level Scale
 None 
 Low 
 Moderate 
 High 
Linear, scaled to High level expression
Tissue   Expression Level
Larval Central Nervous System
 
 0.475
Larval Midgut
 
 1.8
Larval Hindgut
 
 0.7
Larval Malpighian Tubules
 
 1.4
Larval Fat Body
 
 1.8
Larval Salivary Gland
 
 2.7
Larval Trachea
 
 0.65
Larval Carcass
 
 2.075
Adult Head
 
 3.6
Adult Eye
 
 0.8
Adult Brain
 
 0.4
Adult Thoracic-Abdominal Ganglion
 
 0.9
Adult Crop
 
 1.5
Adult Midgut
 
 1.5
Adult Hindgut
 
 1.1
Adult Malpighian Tubules
 
 1.4
Adult Fat Body
 
 2.1
Adult Salivary Gland
 
 2.1
Adult Heart
 
 0.975
Adult VirginFemale Spermatheca
 
 0.9
Adult InseminatedFemale Spermatheca
 
 0.6
Adult Ovary
 
 0.4
Adult Testis
 
 3.5
Adult Male Accessory Gland
 
 1.7
Adult Carcass
 
 2.7
Expression Level Scale
 None 
 Low 
 Moderate 
 High 
 Very high 
Linear, scaled to Very high expression
Tissue   Expression Level
Larval Central Nervous System
 
 0.475
Larval Midgut
 
 1.8
Larval Hindgut
 
 0.7
Larval Malpighian Tubules
 
 1.4
Larval Fat Body
 
 1.8
Larval Salivary Gland
 
 2.7
Larval Trachea
 
 0.65
Larval Carcass
 
 2.075
Adult Head
 
 3.6
Adult Eye
 
 0.8
Adult Brain
 
 0.4
Adult Thoracic-Abdominal Ganglion
 
 0.9
Adult Crop
 
 1.5
Adult Midgut
 
 1.5
Adult Hindgut
 
 1.1
Adult Malpighian Tubules
 
 1.4
Adult Fat Body
 
 2.1
Adult Salivary Gland
 
 2.1
Adult Heart
 
 0.975
Adult VirginFemale Spermatheca
 
 0.9
Adult InseminatedFemale Spermatheca
 
 0.6
Adult Ovary
 
 0.4
Adult Testis
 
 3.5
Adult Male Accessory Gland
 
 1.7
Adult Carcass
 
 2.7
Expression Level Scale
 Very high 
log, scaled to maximum expression level
Tissue   Expression Level
Larval Central Nervous System
 
 0.475
Larval Midgut
 
 1.8
Larval Hindgut
 
 0.7
Larval Malpighian Tubules
 
 1.4
Larval Fat Body
 
 1.8
Larval Salivary Gland
 
 2.7
Larval Trachea
 
 0.65
Larval Carcass
 
 2.075
Adult Head
 
 3.6
Adult Eye
 
 0.8
Adult Brain
 
 0.4
Adult Thoracic-Abdominal Ganglion
 
 0.9
Adult Crop
 
 1.5
Adult Midgut
 
 1.5
Adult Hindgut
 
 1.1
Adult Malpighian Tubules
 
 1.4
Adult Fat Body
 
 2.1
Adult Salivary Gland
 
 2.1
Adult Heart
 
 0.975
Adult VirginFemale Spermatheca
 
 0.9
Adult InseminatedFemale Spermatheca
 
 0.6
Adult Ovary
 
 0.4
Adult Testis
 
 3.5
Adult Male Accessory Gland
 
 1.7
Adult Carcass
 
 2.7
Expression Level Scale
 None 
 Low 
log, scaled to Moderate expression
Tissue   Expression Level
Larval Central Nervous System
 
 0.475
Larval Midgut
 
 1.8
Larval Hindgut
 
 0.7
Larval Malpighian Tubules
 
 1.4
Larval Fat Body
 
 1.8
Larval Salivary Gland
 
 2.7
Larval Trachea
 
 0.65
Larval Carcass
 
 2.075
Adult Head
 
 3.6
Adult Eye
 
 0.8
Adult Brain
 
 0.4
Adult Thoracic-Abdominal Ganglion
 
 0.9
Adult Crop
 
 1.5
Adult Midgut
 
 1.5
Adult Hindgut
 
 1.1
Adult Malpighian Tubules
 
 1.4
Adult Fat Body
 
 2.1
Adult Salivary Gland
 
 2.1
Adult Heart
 
 0.975
Adult VirginFemale Spermatheca
 
 0.9
Adult InseminatedFemale Spermatheca
 
 0.6
Adult Ovary
 
 0.4
Adult Testis
 
 3.5
Adult Male Accessory Gland
 
 1.7
Adult Carcass
 
 2.7
Expression Level Scale
 None 
 Low 
 Moderate 
 High 
log, scaled to High level expression
Tissue   Expression Level
Larval Central Nervous System
 
 0.475
Larval Midgut
 
 1.8
Larval Hindgut
 
 0.7
Larval Malpighian Tubules
 
 1.4
Larval Fat Body
 
 1.8
Larval Salivary Gland
 
 2.7
Larval Trachea
 
 0.65
Larval Carcass
 
 2.075
Adult Head
 
 3.6
Adult Eye
 
 0.8
Adult Brain
 
 0.4
Adult Thoracic-Abdominal Ganglion
 
 0.9
Adult Crop
 
 1.5
Adult Midgut
 
 1.5
Adult Hindgut
 
 1.1
Adult Malpighian Tubules
 
 1.4
Adult Fat Body
 
 2.1
Adult Salivary Gland
 
 2.1
Adult Heart
 
 0.975
Adult VirginFemale Spermatheca
 
 0.9
Adult InseminatedFemale Spermatheca
 
 0.6
Adult Ovary
 
 0.4
Adult Testis
 
 3.5
Adult Male Accessory Gland
 
 1.7
Adult Carcass
 
 2.7
Expression Level Scale
 None 
 Low 
 Moderate 
 High 
 Very high 
log, scaled to Very high expression
Tissue   Expression Level
Larval Central Nervous System
 
 0.475
Larval Midgut
 
 1.8
Larval Hindgut
 
 0.7
Larval Malpighian Tubules
 
 1.4
Larval Fat Body
 
 1.8
Larval Salivary Gland
 
 2.7
Larval Trachea
 
 0.65
Larval Carcass
 
 2.075
Adult Head
 
 3.6
Adult Eye
 
 0.8
Adult Brain
 
 0.4
Adult Thoracic-Abdominal Ganglion
 
 0.9
Adult Crop
 
 1.5
Adult Midgut
 
 1.5
Adult Hindgut
 
 1.1
Adult Malpighian Tubules
 
 1.4
Adult Fat Body
 
 2.1
Adult Salivary Gland
 
 2.1
Adult Heart
 
 0.975
Adult VirginFemale Spermatheca
 
 0.9
Adult InseminatedFemale Spermatheca
 
 0.6
Adult Ovary
 
 0.4
Adult Testis
 
 3.5
Adult Male Accessory Gland
 
 1.7
Adult Carcass
 
 2.7
Expression Level Scale
 None 
 Low 
 Moderate 
 High 
 Very high 
Heatmap
Tissue   Expression Level
Larval Central Nervous System
 
 
Larval Midgut
 
 
Larval Hindgut
 
 
Larval Malpighian Tubules
 
 
Larval Fat Body
 
 
Larval Salivary Gland
 
 
Larval Trachea
 
 
Larval Carcass
 
 
Adult Head
 
 
Adult Eye
 
 
Adult Brain
 
 
Adult Thoracic-Abdominal Ganglion
 
 
Adult Crop
 
 
Adult Midgut
 
 
Adult Hindgut
 
 
Adult Malpighian Tubules
 
 
Adult Fat Body
 
 
Adult Salivary Gland
 
 
Adult Heart
 
 
Adult VirginFemale Spermatheca
 
 
Adult InseminatedFemale Spermatheca
 
 
Adult Ovary
 
 
Adult Testis
 
 
Adult Male Accessory Gland
 
 
Adult Carcass
 
 

FlyAtlas Organ/Tissue Expression, larval vs. adult
Larval Expression Level Tissue Adult Expression Level
 
NA 
Head
 
 3.6
 
NA 
Eye
 
 0.8
 
NA 
Brain
 
 0.4
 
0.475 
Central Nervous System
 
 NA
 
NA 
Thoracic-Abdominal Ganglion
 
 0.9
 
NA 
Crop
 
 1.5
 
1.8 
Midgut
 
 1.5
 
0.7 
Hindgut
 
 1.1
 
1.4 
Malpighian Tubules
 
 1.4
 
1.8 
Fat Body
 
 2.1
 
2.7 
Salivary Gland
 
 2.1
 
NA 
Heart
 
 0.975
 
0.65 
Trachea
 
 NA
 
NA 
VirginFemale Spermatheca
 
 0.9
 
NA 
InseminatedFemale Spermatheca
 
 0.6
 
NA 
Ovary
 
 0.4
 
NA 
Testis
 
 3.5
 
NA 
Male Accessory Gland
 
 1.7
 
2.075 
Carcass
 
 2.7

FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
hide modENCODE Anatomy RNA-Seq
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modENCODE Temporal Expression Data (Graveley et al., 2011)
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hide Expression Clusters
A cluster of genes with similar mRNA expression dynamics across development.
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Linkouts
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
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hide Summary of Allele Phenotypes
Lethality
Allele
Other Phenotypes
Allele
Phenotype manifest in
Allele
hide Classical Alleles ( 2 )
For All Classical Alleles Show

Allele of Ir84aClassMutagenStocksKnown lesion
Ir84aGAL41 Yes
Ir84aMI00501
1 --
hide Alleles Carried on Transgenic Constructs ( 7 )
For All Alleles Carried on Transgenic Constructs Show

Allele of Ir84aClassMutagenStocksKnown lesion
Ir84aGD28442 Yes
Ir84aKK1039851 Yes
Ir84aScer\UAS.cBa1 Yes
Ir84aR317A.Scer\UAS.T:Hsap\CALR,T:Avic\GFP-EGFP0 Yes
Ir84aScer\UAS.T:Hsap\CALR,T:Avic\GFP-EGFP0 Yes
Ir84aΔC.Scer\UAS.T:Hsap\CALR,T:Avic\GFP-EGFP0 Yes
Ir84aΔN.Scer\UAS.T:Hsap\CALR,T:Avic\GFP-EGFP0 Yes
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Disrupted in
hide Transgenic Constructs & Insertions
Transgenic Constructs
Type of construct
Name
Expression data
GAL4 construct
characterization construct
Insertions
Type of insertions
Name
Expression data
miscellaneous insertions
hide Gene Ontology: Function, Process & Cellular Component ( 13 unique terms )
hide Terms Based on Experimental Evidence ( 7 terms )
Molecular Function
CV term
References
Biological Process
CV term
References
inferred from mutant phenotype
Cellular Component
CV term
References
inferred from direct assay
inferred from direct assay
inferred from direct assay
inferred from direct assay
hide Terms Based on Predictions or Assertions ( 6 terms )
Molecular Function
CV term
References
inferred from electronic annotation with InterPro:IPR001320
inferred from sequence or structural similarity
inferred from sequence or structural similarity with UniProtKB:Q16478
inferred from sequence or structural similarity with mouse Grik5
Biological Process
CV term
References
inferred from sequence or structural similarity with UniProtKB:Q16478
Cellular Component
CV term
References
inferred from sequence model
inferred from sequence or structural similarity with mouse Grik5
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hide Summary of Physical Interactions
protein-protein
Interacting group
Assay
References
inferred by author, fluorescence microscopy, tag visualisation
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Interacts with
Please look at the allele data for full details of the genetic interactions
Ir84a allele
Gene
References
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Linkouts
DroID - A comprehensive database of gene and protein interactions.
hide Orthologs
hide OrthoDB Orthologs (17) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
Drosophila inclusive ortholog search
Dipteran inclusive ortholog search
Insect inclusive ortholog search
No orthologs identified
Arthropod inclusive ortholog search
No orthologs identified
Metazoa inclusive ortholog search
No orthologs identified
hideOrthologs in Drosophila Species (EOG69KG97)
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila melanogaster
fruit fly 
 
 
Drosophila simulans
 
Y
 
Drosophila sechellia
 
Y
 
Drosophila erecta
 
Y
 
Drosophila yakuba
 
Y
 
Drosophila yakuba
 
 
 
Drosophila ananassae
 
Y
 
Drosophila pseudoobscura pseudoobscura
 
 
 
Drosophila persimilis
 
Y
 
Drosophila willistoni
 
Y
 
Drosophila virilis
 
Y
 
Drosophila mojavensis
 
Y
 
Drosophila grimshawi
 
Y
 
hideOrthologs in non-Drosophila Dipterans (EOG6VT65J)
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Anopheles gambiae
Malaria mosquito 
 
Anopheles gambiae
Malaria mosquito 
 
Culex quinquefasciatus
Southern house mosquito 
 
Culex quinquefasciatus
Southern house mosquito 
 
Orthologs in non-Dipteran Insects (None identified)
No non-Dipteran orthologies identified
Orthologs in non-Insect Arthropods (None identified)
No non-Insect Arthropod orthologies identified
Orthologs in non-Arthropod Metazoa (None identified)
No non-Arthropod Metazoa orthologies identified
hide Human Orthologs (0)
Gene
OMIM
HGNC
hideAAA Orthologs (10) based on analysis using Dmel annotation version 4.3
Organism
Gene
Drosophila simulans
Drosophila sechellia
Drosophila erecta
Drosophila yakuba
Drosophila ananassae
Drosophila persimilis
Drosophila willistoni
Drosophila virilis
Drosophila mojavensis
Drosophila grimshawi
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hide Stocks Listed in FlyBase ( 6 )
Bloomington
VDRC
hide Genomic Clones ( 2 )
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
hide cDNA Clones ( 0 )
Please Note
This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones
Other clones
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Linkouts
DRSC - Results from RNAi screens.
GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents
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Source for database identity of
Source for identity of: Ir84a CG10101
Source for database merge of
Additional comments
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Sequence Crossreferences
RefSeq (Transcripts)
RefSeq (Proteins)
Entrez Gene - A searchable database of RefSeq genes.
Other Crossreferences
InterPro domains - A database of protein families, domains, and functional sites
Linkouts
DroID - A comprehensive database of gene and protein interactions.
DRSC - Results from RNAi screens.
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans
GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents
modMine - Data generated by the modENCODE project.
hide Synonyms & Secondary IDs ( 7 )
Reported As
Symbol Synonym
Name Synonym
CG10101
 
ionotropic receptor 84a
Secondary FlyBase IDs
hide References ( 22 )
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List References by type
hide Recent research papers ( 4 )
Krauchunas et al., 2012, Dev. Biol. 370(1): 125--134
Protein phosphorylation changes reveal new candidates in the regulation of egg activation and early embryogenesis in D. melanogaster. [FBrf0219342]
Abuin et al., 2011, Neuron 69(1): 44--60
Functional architecture of olfactory ionotropic glutamate receptors. [FBrf0212725]
Grosjean et al., 2011, Nature 478(7368): 236--240
An olfactory receptor for food-derived odours promotes male courtship in Drosophila. [FBrf0216424]
Silbering et al., 2011, J. Neurosci. 31(38): 13357--13375
Complementary Function and Integrated Wiring of the Evolutionarily Distinct Drosophila Olfactory Subsystems. [FBrf0215822]