FB2021_06, released December 14, 2021

Gene: Dmel\Sp7

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General Information
Symbol
Dmel\Sp7
Species
D. melanogaster
Name
Serine protease 7
Annotation Symbol
CG3066
Feature Type
protein_coding_gene
FlyBase ID
FBgn0037515
Gene Model Status
Current
Stock Availability
6 publicly available
Gene Summary
Serine protease 7 (Sp7) encodes a hemolymphatic serine protease involved in the activation of the melanization cascade. [Date last reviewed: 2019-03-14] (FlyBase Gene Snapshot)
All Summaries
Also Known As

MP2, PAE1, Melanization Protease 2

Key Links
Genomic Location
Cytogenetic map
84D14-84E1
Sequence location
Recombination map
3-48
RefSeq locus
NT_033777 REGION:7759786..7763947
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (7 terms)
Molecular Function (1 term)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
enables serine-type endopeptidase activity
inferred from sequence model
(Cao and Jiang, 2018, Kelleher and Pennington, 2009, Ross et al., 2003)
inferred from biological aspect of ancestor with PANTHER:PTN001207268
(assigned by GO_Central )
(Gaudet et al., 2011)
Biological Process (4 terms)
Terms Based on Experimental Evidence (3 terms)
CV Term
Evidence
References
involved_in defense response to Gram-positive bacterium
inferred from mutant phenotype
(Dudzic et al., 2019)
involved_in melanization defense response
inferred from mutant phenotype
(Bidla et al., 2007, Tang et al., 2006)
involved_in positive regulation of melanization defense response
inferred from genetic interaction with FLYBASE:PPO1; FB:FBgn0283437
(Dudzic et al., 2019)
inferred from mutant phenotype
(Castillejo-Lopez and Häcker, 2005)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
involved_in proteolysis
inferred from sequence model
(Kelleher and Pennington, 2009, Ross et al., 2003)
inferred from biological aspect of ancestor with PANTHER:PTN001207268
(assigned by GO_Central )
(Gaudet et al., 2011)
Cellular Component (2 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
located_in extracellular region
inferred from high throughput direct assay
(Karlsson et al., 2004)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
is_active_in extracellular space
inferred from biological aspect of ancestor with PANTHER:PTN001207268
(assigned by GO_Central )
(Gaudet et al., 2011)
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the peptidase S1 family. CLIP subfamily. (Q9V3Z2)
Protein Signatures (InterPro)
Summaries
Gene Snapshot
Serine protease 7 (Sp7) encodes a hemolymphatic serine protease involved in the activation of the melanization cascade. [Date last reviewed: 2019-03-14]
Gene Group (FlyBase)
S1A SERINE PROTEASES - TRYPSIN-LIKE -
Trypsin-like serine proteases of the S1A family are endopeptidases that cleave amide substrates following Arginine or Lysine at the P1 position. (Adapted from FBrf0239469).
Protein Function (UniProtKB)
Serine protease which, by cleaving and activating prophenoloxidase (PPO1) after immune challenge, plays an essential role in the melanization immune response to septic wounding (PubMed:16256951, PubMed:16322759, PubMed:19071960, PubMed:24260243, PubMed:16861233). May function in diverse Hayan-dependent PPO1-activating cascades that are negatively controlled by different serpin proteins; Spn27A in the hemolymph and Spn77BA in the trachea (PubMed:18854145, PubMed:24260243, PubMed:16322759). Important for the innate immune response to fungi (PubMed:16861233). Regulation of melanization and PPO1 activation appears to be largely independent of the Toll signaling pathway (PubMed:16861233).
(UniProt, Q9V3Z2)
Gene Model and Products
Number of Transcripts
3
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\Sp7 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Gene model reviewed during 5.49

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 6.03

Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Sp7-RA
FBtr0081740
NM_141477
1851
391
Sp7-RE
FBtr0339180
NM_169192
1418
391
Sp7-RF
FBtr0339181
NM_169193
1939
391
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
Sp7-PA
FBpp0081237
43.1
391
6.59
NP_649734
AAF54143
Sp7-PE
FBpp0308321
43.1
391
6.59
NP_731174
AAG22126
Sp7-PF
FBpp0308322
43.1
391
6.59
NP_731175
AAG22127
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

391 aa isoforms: Sp7-PA, Sp7-PE, Sp7-PF
Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Subunit Structure (UniProtKB)

Interacts with Spn27A.

(UniProt, Q9V3Z2)
Domain

The clip domain consists of 35-55 residues which are 'knitted' together usually by 3 conserved disulfide bonds forming a clip-like compact structure.

(UniProt, Q9V3Z2)
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Sp7 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in extracellular region
inferred from high throughput direct assay
(Karlsson et al., 2004)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Sp7 in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 4 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 15 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Sp7
Transgenic constructs containing regulatory region of Sp7
Aberrations (Deficiencies and Duplications) ( 0 )
Inferred from experimentation ( 0 )
Inferred from location ( 0 )
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal, with Scer\GAL4Act.PU
lethal, with Scer\GAL4da.G32
lethal - all die before end of pupal stage, with Scer\GAL4Act.PU
partially lethal, with Scer\GAL4Act.PU
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4Mef2.PR
viable, with Scer\GAL4pnr-MD237
viable, with Scer\GAL4unspecified
Other Phenotypes
Allele
abnormal immune response, with Scer\GAL4da.G32
abnormal immune response | adult stage
abnormal immune response | larval stage
abnormal wound healing, with Scer\GAL4Act.PU
melanotic mass phenotype, with Scer\GAL4da.G32
melanotic mass phenotype | adult stage, with Scer\GAL4Act.PU
melanotic mass phenotype | larval stage, with Scer\GAL4Act.PU
melanotic mass phenotype | pupal stage, with Scer\GAL4Act.PU
short lived | conditional
some die during pupal stage, with Scer\GAL4Act.PU
Phenotype manifest in
Allele
embryonic/larval hemolymph | third instar larval stage, with Scer\GAL4lz-gal4
melanotic mass, with Scer\GAL4da.G32
melanotic mass | adult stage, with Scer\GAL4Act.PU
melanotic mass | larval stage, with Scer\GAL4Act.PU
melanotic mass | P-stage, with Scer\GAL4Act.PU
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (7)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\F10
1 of 15
Yes
No
1  
Hsap\PRSS45P
1 of 15
Yes
No
Hsap\PRSS54
1 of 15
Yes
No
Hsap\TPSAB1
1 of 15
Yes
No
Hsap\TPSB2
1 of 15
Yes
No
Hsap\TPSD1
1 of 15
Yes
No
Hsap\TPSG1
1 of 15
Yes
No
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (7)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\F10
1 of 15
Yes
No
Mmus\Prss28
1 of 15
Yes
No
Mmus\Prss29
1 of 15
Yes
No
Mmus\Prss45
1 of 15
Yes
No
Mmus\Tpsab1
1 of 15
Yes
No
Mmus\Tpsb2
1 of 15
Yes
No
Mmus\Tpsg1
1 of 15
Yes
No
Rattus norvegicus (Norway rat) (9)
Rnor\C1s
1 of 13
Yes
No
Rnor\F10
1 of 13
Yes
No
Rnor\LOC685321
1 of 13
Yes
No
Rnor\Prss29
1 of 13
Yes
No
Rnor\Prss45
1 of 13
Yes
No
Rnor\RGD1559662
1 of 13
Yes
No
Rnor\Tpsab1
1 of 13
Yes
No
Rnor\Tpsb2
1 of 13
Yes
No
Rnor\Tpsg1
1 of 13
Yes
No
Xenopus tropicalis (Western clawed frog) (3)
Xtro\f10
1 of 12
Yes
No
Xtro\LOC100145345
1 of 12
Yes
Yes
Xtro\LOC108644439
1 of 12
Yes
Yes
Danio rerio (Zebrafish) (21)
Drer\LOC100004427
2 of 15
Yes
No
Drer\si:dkey-16l2.17
2 of 15
Yes
No
Drer\si:dkey-32n7.7
2 of 15
Yes
No
Drer\zgc:92313
2 of 15
Yes
No
Drer\zgc:112038
2 of 15
Yes
No
Drer\zgc:123295
2 of 15
Yes
No
Drer\zgc:153968
2 of 15
Yes
No
Drer\zgc:163079
2 of 15
Yes
No
Drer\f10
1 of 15
No
No
Drer\gzma
1 of 15
No
No
Drer\gzmk
1 of 15
No
No
Drer\LOC100004411
1 of 15
No
Yes
Drer\masp2
1 of 15
No
Yes
Drer\prss60.1
1 of 15
No
No
Drer\prss60.2
1 of 15
No
No
Drer\prss60.3
1 of 15
No
No
Drer\si:dkey-9p24.5
1 of 15
No
No
Drer\si:dkeyp-93a5.2
1 of 15
No
No
Drer\si:dkeyp-93a5.3
1 of 15
No
No
Drer\zgc:123217
1 of 15
No
No
Drer\zgc:165423
1 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (2)
Cele\try-1
1 of 15
Yes
No
Cele\try-3
1 of 15
Yes
No
Arabidopsis thaliana (thale-cress) (0)
No records found.
Saccharomyces cerevisiae (Brewer's yeast) (0)
No records found.
Schizosaccharomyces pombe (Fission yeast) (0)
No records found.
Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG0919096S )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00013450
Drosophila simulans
Dsim\GD19946
Drosophila sechellia
Dsec\GM10972
Drosophila erecta
Dere\GG14174
Drosophila yakuba
Dyak\GE24940
Drosophila ananassae
Dana\GF17682
Drosophila pseudoobscura pseudoobscura
Dpse\GA15903
Drosophila pseudoobscura pseudoobscura
Dpse\GA27509
Drosophila persimilis
Dper\GL12453
Drosophila willistoni
Dwil\GK12018
Drosophila virilis
Dvir\GJ10951
Drosophila mojavensis
Dmoj\GI24127
Drosophila grimshawi
Dgri\GH18317
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091505N5 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17012077
Musca domestica
House fly
Mdoa\17018071
Musca domestica
House fly
Mdoa\17012085
Musca domestica
House fly
Mdoa\17024407
Musca domestica
House fly
Mdoa\17012078
Musca domestica
House fly
Mdoa\17021797
Musca domestica
House fly
Mdoa\17015292
Glossina morsitans
Tsetse fly
Gmor\GMOY002008
Glossina morsitans
Tsetse fly
Gmor\GMOY008308
Glossina morsitans
Tsetse fly
Gmor\GMOY008966
Glossina morsitans
Tsetse fly
Gmor\GMOY002535
Glossina morsitans
Tsetse fly
Gmor\GMOY006266
Glossina morsitans
Tsetse fly
Gmor\GMOY008964
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_04952
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_12589
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_03611
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_05582
Mayetiola destructor
Hessian fly
Mdes\Mdes019795
Mayetiola destructor
Hessian fly
Mdes\Mdes011716
Aedes aegypti
Yellow fever mosquito
Aaeg\CLIPB44
Aedes aegypti
Yellow fever mosquito
Aaeg\CLIPB34
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL014139
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL015637
Aedes aegypti
Yellow fever mosquito
Aaeg\CLIPB9
Aedes aegypti
Yellow fever mosquito
Aaeg\CLIPB35
Aedes aegypti
Yellow fever mosquito
Aaeg\CLIPB8
Aedes aegypti
Yellow fever mosquito
Aaeg\CLIPB33
Aedes aegypti
Yellow fever mosquito
Aaeg\CLIPB24
Aedes aegypti
Yellow fever mosquito
Aaeg\CLIPB1
Aedes aegypti
Yellow fever mosquito
Aaeg\CLIPB29
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL003642
Aedes aegypti
Yellow fever mosquito
Aaeg\CLIPB6
Anopheles darlingi
American malaria mosquito
Adar\ADAC008852
Anopheles darlingi
American malaria mosquito
Adar\ADAC007807
Anopheles darlingi
American malaria mosquito
Adar\ADAC008849
Anopheles darlingi
American malaria mosquito
Adar\ADAC008847
Anopheles darlingi
American malaria mosquito
Adar\ADAC007905
Anopheles darlingi
American malaria mosquito
Adar\ADAC007805
Anopheles darlingi
American malaria mosquito
Adar\ADAC009221
Anopheles darlingi
American malaria mosquito
Adar\ADAC007806
Anopheles darlingi
American malaria mosquito
Adar\ADAC008845
Anopheles gambiae
Malaria mosquito
Agam\CLIPB19
Anopheles gambiae
Malaria mosquito
Agam\CLIPB2
Anopheles gambiae
Malaria mosquito
Agam\AGAP011325
Anopheles gambiae
Malaria mosquito
Agam\CLIPB18
Anopheles gambiae
Malaria mosquito
Agam\AGAP004149
Anopheles gambiae
Malaria mosquito
Agam\CLIPB3
Anopheles gambiae
Malaria mosquito
Agam\SRPN5
Anopheles gambiae
Malaria mosquito
Agam\CLIPB4
Anopheles gambiae
Malaria mosquito
Agam\CLIPB11
Anopheles gambiae
Malaria mosquito
Agam\CLIPB5
Anopheles gambiae
Malaria mosquito
Agam\AGAP013487
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ004038
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ009130
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ010296
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ004037
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ016225
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ016222
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ009624
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ018737
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ000393
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ004036
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ010297
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ010295
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ017738
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ016224
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ020109
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ020127
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ010641
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ009625
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ010298
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ016221
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W05F8 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA005172
Bombyx mori
Silkmoth
Bmor\BGIBMGA005173
Bombyx mori
Silkmoth
Bmor\BGIBMGA010546
Bombyx mori
Silkmoth
Bmor\BGIBMGA013746
Bombyx mori
Silkmoth
Bmor\BGIBMGA013797
Danaus plexippus
Monarch butterfly
Dple\DPOGS204146-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS214570-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS206561-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS206562-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS204148-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS201966-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS204147-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL004369
Heliconius melpomene
Postman butterfly
Hmel\HMEL016481
Heliconius melpomene
Postman butterfly
Hmel\HMEL002402
Heliconius melpomene
Postman butterfly
Hmel\HMEL016482
Apis florea
Little honeybee
Aflo\2147487859
Apis mellifera
Western honey bee
Amel\SP2
Apis mellifera
Western honey bee
Amel\GB45701
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP18839
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP18838
Bombus terrestris
Buff-tailed bumblebee
Bter\15217019
Linepithema humile
Argentine ant
Lhum\LH23044
Linepithema humile
Argentine ant
Lhum\LH26166
Linepithema humile
Argentine ant
Lhum\LH26165
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:0026a7
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG020294
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG006450
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG020297
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG020295
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG008973
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG020296
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_13086
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_00031
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_12472
Tribolium castaneum
Red flour beetle
Tcas\P139
Tribolium castaneum
Red flour beetle
Tcas\P93
Tribolium castaneum
Red flour beetle
Tcas\TC009089
Tribolium castaneum
Red flour beetle
Tcas\TC031198
Tribolium castaneum
Red flour beetle
Tcas\P138
Tribolium castaneum
Red flour beetle
Tcas\P8
Tribolium castaneum
Red flour beetle
Tcas\P91
Tribolium castaneum
Red flour beetle
Tcas\H137
Tribolium castaneum
Red flour beetle
Tcas\H33
Tribolium castaneum
Red flour beetle
Tcas\TC002193
Tribolium castaneum
Red flour beetle
Tcas\TC034786
Tribolium castaneum
Red flour beetle
Tcas\P136
Tribolium castaneum
Red flour beetle
Tcas\TC032161
Pediculus humanus
Human body louse
Phum\PHUM501910
Pediculus humanus
Human body louse
Phum\PHUM546610
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI086736
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI000392
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_10161
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_10162
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X00SF )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR012580
Strigamia maritima
European centipede
Smar\SMAR007568
Strigamia maritima
European centipede
Smar\SMAR011638
Strigamia maritima
European centipede
Smar\SMAR009095
Strigamia maritima
European centipede
Smar\SMAR010212
Strigamia maritima
European centipede
Smar\SMAR004518
Strigamia maritima
European centipede
Smar\SMAR004271
Strigamia maritima
European centipede
Smar\SMAR004270
Strigamia maritima
European centipede
Smar\SMAR007569
Strigamia maritima
European centipede
Smar\SMAR001810
Strigamia maritima
European centipede
Smar\SMAR011650
Strigamia maritima
European centipede
Smar\SMAR007984
Strigamia maritima
European centipede
Smar\SMAR011637
Ixodes scapularis
Black-legged tick
Isca\ISCW017406
Ixodes scapularis
Black-legged tick
Isca\ISCW012715
Ixodes scapularis
Black-legged tick
Isca\ISCW013013
Ixodes scapularis
Black-legged tick
Isca\ISCW002148
Ixodes scapularis
Black-legged tick
Isca\ISCW023822
Ixodes scapularis
Black-legged tick
Isca\ISCW009051
Ixodes scapularis
Black-legged tick
Isca\ISCW000363
Ixodes scapularis
Black-legged tick
Isca\ISCW002999
Ixodes scapularis
Black-legged tick
Isca\ISCW002695
Ixodes scapularis
Black-legged tick
Isca\ISCW007529
Ixodes scapularis
Black-legged tick
Isca\ISCW012782
Ixodes scapularis
Black-legged tick
Isca\ISCW011978
Stegodyphus mimosarum
African social velvet spider
Smim\KFM57227.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM63497.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM69848.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur01g04580
Tetranychus urticae
Two-spotted spider mite
Turt\tetur02g03090
Tetranychus urticae
Two-spotted spider mite
Turt\tetur11g03930
Tetranychus urticae
Two-spotted spider mite
Turt\tetur19g00740
Tetranychus urticae
Two-spotted spider mite
Turt\tetur03g09590
Tetranychus urticae
Two-spotted spider mite
Turt\tetur23g00450
Tetranychus urticae
Two-spotted spider mite
Turt\tetur08g06100
Tetranychus urticae
Two-spotted spider mite
Turt\tetur01g02990
Tetranychus urticae
Two-spotted spider mite
Turt\tetur02g01640
Tetranychus urticae
Two-spotted spider mite
Turt\tetur01g08540
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_216354
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_46683
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_57846
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_9346
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_347765
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_347769
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_60765
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_305928
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_304284
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_347773
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_308787
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_347777
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_323226
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_228481
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_299571
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_304142
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_323225
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_107786
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_54608
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_26576
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_312683
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_318727
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_347782
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_347781
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_347804
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_256105
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_304051
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0DF7 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr146
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Polsrs
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr224
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Sr/Lrr/Gpcr
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr22
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr197
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr149
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr13
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Klkb1
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr96
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr120
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr167
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr53
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Ly/Cub/Sr/Zp
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr196
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Ela2L
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr1
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr215
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Tmprss9L
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr59
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr64
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Hypp_1191
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr105
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr218
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr170
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr227
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr85
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-GramarL3
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr66
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr136
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr25
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr61
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr71
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Dmbt1L_5
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr82
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr8
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr52
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr222
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr40
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Prss12L
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr23
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr77
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr127
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr134
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr10
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr223
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr63
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Sr/Gpcr
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr83
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr32
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr101
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr100
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Tmprss6
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr12_1
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr113
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Dmbt1L_10
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr107
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr219
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr189
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr57
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr4
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr122
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr154
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr188
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr104
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-NotchL_2
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Tmps9
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr192
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr81
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-St14L_4
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr5
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr28
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-KlkB
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr220
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr69
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr60
Strongylocentrotus purpuratus
Purple sea urchin
Spur\SPU_015154gn
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Lrp4_6
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr176
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr194
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr15
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Sr/Egf/Lnb/7Tm/Gpcr
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-St14L_29
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr79
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr161
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr91
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Sr/Lrr/Gpcr_2
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr123
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-trypsinL_2
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr172
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr166
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Sr/Lrr/Gpcr_3
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr137
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Tmprss9
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr213
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Egfia_5
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-trypsinL_1
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr163
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Dmbt1L
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Sorl1L
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr14
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Lrp2L
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr179
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr92
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Hypp_143
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr206
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Tmprss3
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr18
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Dmbt1L_3
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr50
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr165
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr42
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr75
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Egfiii
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Masp
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr204
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr48
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr94
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr228
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr193
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Cubn-5
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Hypp_2211
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr34
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr97
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr37
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr214
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr112
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr80
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Tll2L_1
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr46
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Hypp_73
Strongylocentrotus purpuratus
Purple sea urchin
Spur\SPU_026637gn
Strongylocentrotus purpuratus
Purple sea urchin
Spur\SPU_000926gn
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr216
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Prss7_1
Strongylocentrotus purpuratus
Purple sea urchin
Spur\SPU_001110gn
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr174
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr143
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr187
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Tmprss9L_1
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr226
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr159
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr43
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr76
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr173
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr11
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr47
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr152
Strongylocentrotus purpuratus
Purple sea urchin
Spur\SPU_018949gn
Strongylocentrotus purpuratus
Purple sea urchin
Spur\SPU_026926gn
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr114
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr160
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr198
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr86
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr221
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr180
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr103
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-St14L_2
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-GramarL2
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-trypsinL
Strongylocentrotus purpuratus
Purple sea urchin
Spur\SPU_010210gn
Strongylocentrotus purpuratus
Purple sea urchin
Spur\SPU_003549gn
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr119
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr125
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr108
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr147
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Dmbt1L_6
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr207
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr70
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Clect_113
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-GramarL1
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr9
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr110
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr155
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Klkb1L1
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr2
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr44
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr51
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr116
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr157
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Cgsp1
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Tmprss9_2
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr72
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr106
Strongylocentrotus purpuratus
Purple sea urchin
Spur\SPU_005658gn
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-St14L
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr175
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Tmprss2L_2
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr142
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr118
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr162
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-trypsinL_3
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr56
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr58
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr225
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr121
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Hypp_119
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr24
Strongylocentrotus purpuratus
Purple sea urchin
Spur\SPU_003041gn
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Hypp_242
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr153
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr65
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr210
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr84
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Sea/Ldla/Cub
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-EgfiiiL
Strongylocentrotus purpuratus
Purple sea urchin
Spur\SPU_020206gn
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr164
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr144
Strongylocentrotus purpuratus
Purple sea urchin
Spur\SPU_005560gn
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Dmbt1L_4
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr186
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr6
Strongylocentrotus purpuratus
Purple sea urchin
Spur\SPU_022975gn
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr29
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Prss7L
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr41
Strongylocentrotus purpuratus
Purple sea urchin
Spur\SPU_019928gn
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr78
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr129
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Hypp_373
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr30
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr26
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr67
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr93
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr68
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr208
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Tmprss5L
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr168
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr191
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr169
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Tmprss2L
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr95
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr141
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-St14L_3
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srcr145
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-SerpineL
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Tmprss3_1
Ciona intestinalis
Vase tunicate
Cint\LOC100175526
Ciona intestinalis
Vase tunicate
Cint\LOC100183060
Ciona intestinalis
Vase tunicate
Cint\LOC100187393
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000018117
Ciona intestinalis
Vase tunicate
Cint\LOC100177359
Ciona intestinalis
Vase tunicate
Cint\LOC100178581
Ciona intestinalis
Vase tunicate
Cint\LOC101242191
Ciona intestinalis
Vase tunicate
Cint\LOC100177776
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000016095
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000018648
Ciona intestinalis
Vase tunicate
Cint\LOC100179458
Ciona intestinalis
Vase tunicate
Cint\LOC100175462
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000007782
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000020354
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000020838
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000023443
Ciona intestinalis
Vase tunicate
Cint\LOC100182594
Ciona intestinalis
Vase tunicate
Cint\LOC100182053
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000013897
Ciona intestinalis
Vase tunicate
Cint\LOC100182205
Ciona intestinalis
Vase tunicate
Cint\LOC100183738
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000003449
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000007451
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000023472
Ciona intestinalis
Vase tunicate
Cint\LOC100185223
Ciona intestinalis
Vase tunicate
Cint\LOC100185892
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000009644
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000009888
Ciona intestinalis
Vase tunicate
Cint\LOC100187379
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000006812
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000016299
Ciona intestinalis
Vase tunicate
Cint\LOC100179089
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000009588
Gallus gallus
Domestic chicken
Ggal\PRSS7
Gallus gallus
Domestic chicken
Ggal\TMPRSS6
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000014720
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000028071
Gallus gallus
Domestic chicken
Ggal\TMPRSS7
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000025752
Gallus gallus
Domestic chicken
Ggal\LOC423740
Gallus gallus
Domestic chicken
Ggal\TMPRSS3
Gallus gallus
Domestic chicken
Ggal\LOC423942
Gallus gallus
Domestic chicken
Ggal\LOC418421
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000004866
Gallus gallus
Domestic chicken
Ggal\LOC768817
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000026051
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000009103
Gallus gallus
Domestic chicken
Ggal\ST14
Gallus gallus
Domestic chicken
Ggal\TMPRSS2
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000001917
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000027189
Gallus gallus
Domestic chicken
Ggal\OVCH2
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000002213
Gallus gallus
Domestic chicken
Ggal\TMPRSS11F
Gallus gallus
Domestic chicken
Ggal\CELA2A
Gallus gallus
Domestic chicken
Ggal\PRSS3
Gallus gallus
Domestic chicken
Ggal\PRSS2
Gallus gallus
Domestic chicken
Ggal\PRSS12
Gallus gallus
Domestic chicken
Ggal\LOC770974
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000026134
Gallus gallus
Domestic chicken
Ggal\TMPRSS9
Gallus gallus
Domestic chicken
Ggal\LOC776414
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000028082
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000006081
Gallus gallus
Domestic chicken
Ggal\CORIN
Gallus gallus
Domestic chicken
Ggal\TMPRSS13
Gallus gallus
Domestic chicken
Ggal\LOC100857124
Gallus gallus
Domestic chicken
Ggal\CTRC
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000027497
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000010831
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000009118
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000028894
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (76)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
CG9733
4 of 10
CG11313
4 of 10
ea
4 of 10
CG3117
2 of 10
CG3355
2 of 10
CG4613
2 of 10
CG4793
2 of 10
CG5390
2 of 10
CG8586
2 of 10
CG8738
2 of 10
CG8870
2 of 10
CG9294
2 of 10
CG9737
2 of 10
CG10232
2 of 10
CG11836
2 of 10
CG14990
2 of 10
CG16710
2 of 10
CG18478
2 of 10
CG18557
2 of 10
CG18563
2 of 10
CG18735
2 of 10
CG18754
2 of 10
CG30414
2 of 10
CG31220
2 of 10
CG40160
2 of 10
SPE
2 of 10
SPH93
2 of 10
tpr
2 of 10
aqrs
1 of 10
CG1299
1 of 10
CG1304
1 of 10
CG3505
1 of 10
CG3916
1 of 10
CG4259
1 of 10
CG4477
1 of 10
CG4653
1 of 10
CG4914
1 of 10
CG5909
1 of 10
CG6462
1 of 10
CG6865
1 of 10
CG7142
1 of 10
CG8172
1 of 10
CG9372
1 of 10
CG9673
1 of 10
CG9676
1 of 10
CG10663
1 of 10
CG12133
1 of 10
CG12256
1 of 10
CG14227
1 of 10
CG14892
1 of 10
CG17404
1 of 10
CG18477
1 of 10
CG30082
1 of 10
CG30083
1 of 10
CG30088
1 of 10
CG30287
1 of 10
CG30288
1 of 10
CG30289
1 of 10
CG31219
1 of 10
CG31266
1 of 10
CG31780
1 of 10
CG31827
1 of 10
CG32260
1 of 10
CG32376
1 of 10
CG32523
1 of 10
CG33127
1 of 10
CG33160
1 of 10
CG33225
1 of 10
CG33226
1 of 10
CG34409
1 of 10
CG34458
1 of 10
flz
1 of 10
l(2)k05911
1 of 10
MP1
1 of 10
Ser6
1 of 10
Ser7
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    Functional Complementation Data
    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
    Interactions
    Summary of Physical Interactions
    esyN Network Diagram
    Show neighbor-neighbor interactions:
    Select Layout:
    Legend:
    Protein
    RNA
    Selected Interactor(s)
    Interactions Browser
    View in Interactions Browser
    Please see the Physical Interaction reports below for full details
    protein-protein
    Physical Interaction
    Assay
    References
    Sp7 - PPO1
    enzymatic study, western blot
    (An et al., 2013)
    Sp7 - Spn27A
    comigration in gel electrophoresis, western blot, enzymatic study
    (An et al., 2013)
    Summary of Genetic Interactions
    esyN Network Diagram
    esyN Network Key:
    Suppression
    Enhancement
    View in Interactions Browser
    Please look at the allele data for full details of the genetic interactions
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    Sp7
    suppressible
    MP1
    (Tang et al., 2006)
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    Fadd
    enhanceable
    Sp7
    (Tang et al., 2006)
    Spn77Ba
    suppressible
    Sp7
    (Tang et al., 2008)
    External Data
    Subunit Structure (UniProtKB)
    Interacts with Spn27A.
    (UniProt, Q9V3Z2 )
    Linkouts
    BioGRID - A database of protein and genetic interactions.
    DroID - A comprehensive database of gene and protein interactions.
    MIST (protein-protein) - An integrated Molecular Interaction Database
    Pathways
    Signaling Pathways (FlyBase)
    Metabolic Pathways
    External Data
    Linkouts
    Genomic Location and Detailed Mapping Data
    Chromosome (arm)
    3R
    Recombination map
    3-48
    Cytogenetic map
    84D14-84E1
    Sequence location
    FlyBase Computed Cytological Location
    Cytogenetic map
    Evidence for location
    84D14-84E1
    Limits computationally determined from genome sequence between P{EP}EP3060EP3060 and P{PZ}grn05930
    Experimentally Determined Cytological Location
    Cytogenetic map
    Notes
    References
    Experimentally Determined Recombination Data
    Location

    3-48

    (FlyBase, 2016)

    3-44.4

    (Comeron et al., 2012)
    Left of (cM)
    Right of (cM)
    Notes
    Stocks and Reagents
    Stocks (6)
    Genomic Clones (26)
    cDNA Clones (16)
     

    Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

    cDNA clones, fully sequenced
    BDGP DGC clones
    Other clones
      Drosophila Genomics Resource Center cDNA clones

      For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

      cDNA Clones, End Sequenced (ESTs)
      BDGP DGC clones
      Other clones
      RNAi and Array Information
      Linkouts
      DRSC - Results frm RNAi screens
      GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
      Antibody Information
      Laboratory Generated Antibodies
       
      Commercially Available Antibodies
       
      Other Information
      Relationship to Other Genes
      Source for database identify of

      Source for identity of: Sp7 CG3066

      (Castillejo-Lopez and Häcker, 2005)

      Source for identity of: Sp7 MP2

      (Tang, 2006.2.28)
      Source for database merge of

      Source for merge of: CG3066 anon-Ryu

      (Bayraktaroglu, 2000.8.7)
      Additional comments
      Other Comments

      RNAi of Sp7 reduces melanization at the wound site of infections, indicating that it is involved in the prophenoloxidase cascade.

      (Kambris et al., 2006)
      Origin and Etymology
      Discoverer
      Etymology
      Identification
      External Crossreferences and Linkouts ( 46 )
      Sequence Crossreferences
      NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
      GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
      GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
      RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
      UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
      UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
      Other crossreferences
      Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
      DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
      EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
      Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
      FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
      FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
      Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
      Flygut - An atlas of the Drosophila adult midgut
      GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
      InterPro - A database of protein families, domains and functional sites
      KEGG Genes - Molecular building blocks of life in the genomic space.
      MARRVEL_MODEL - MARRVEL (model organism gene)
      modMine - A data warehouse for the modENCODE project
      Linkouts
      BioGRID - A database of protein and genetic interactions.
      DroID - A comprehensive database of gene and protein interactions.
      DRSC - Results frm RNAi screens
      FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
      FlyMine - An integrated database for Drosophila genomics
      MIST (protein-protein) - An integrated Molecular Interaction Database
      Synonyms and Secondary IDs (19)
      Reported As
      Symbol Synonym
      CG3066
      (Okuda et al., 2016, Veillard et al., 2016, Park et al., 2014, An et al., 2013, Schertel et al., 2013, Wang et al., 2013, Igboin et al., 2012, Nam et al., 2012, Wong et al., 2012, Moule et al., 2010, Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Kelleher and Pennington, 2009, Winterhalter and Fedorka, 2009, Ayres and Schneider, 2008, Scherfer et al., 2008, Shah et al., 2008, Bidla et al., 2007, Waterhouse et al., 2007, Jang et al., 2006, Kambris et al., 2006, Leclerc et al., 2006, Mulinari et al., 2006, Tang et al., 2006, Castillejo-Lopez and Häcker, 2005, Wertheim et al., 2005, Karlsson et al., 2004, Swanson et al., 2004, Christophides et al., 2002, De Gregorio et al., 2001, Lemaitre, 2000.12.20)
      MP2
      (Cao and Jiang, 2018, Veillard et al., 2016, Vlisidou and Wood, 2015, An et al., 2013, Kounatidis and Ligoxygakis, 2012, Nam et al., 2012, Scherfer et al., 2008, Tang et al., 2008, Bidla et al., 2007, Wu and Silverman, 2007, Tang, 2006.2.28, Tang et al., 2006, Tang et al., 2006)
      MP2/sp7/PAE1
      (Younes et al., 2020)
      PAE
      (Quintin et al., 2013)
      PAE1
      (Veillard et al., 2016, Vlisidou and Wood, 2015, Nam et al., 2012, Scherfer et al., 2008, Leclerc et al., 2006)
      SP13
      (Ross et al., 2003)
      SP7
      (Dudzic et al., 2019, Salazar-Jaramillo et al., 2014, Kambris et al., 2006, Ross et al., 2003)
      Sp 7
      (Park et al., 2014)
      Sp7
      (Kumar et al., 2021, Dziedziech et al., 2020, Banerjee et al., 2019, Meltzer et al., 2019, Ordan and Volk, 2016, Veillard et al., 2016, Dudzic et al., 2015, Vlisidou and Wood, 2015, Bonnay et al., 2014, Sytnikova et al., 2014, Wang et al., 2014, Handke et al., 2013, Kemp et al., 2013, Kwon et al., 2013, Ohtani et al., 2013, Japanese National Institute of Genetics, 2012.5.21, Clark et al., 2011, Marshall and Sinclair, 2010, Obbard et al., 2009, Kambris et al., 2006, Castillejo-Lopez and Häcker, 2005)
      anon-Ryu
      cSP7
      (Cao and Jiang, 2018)
      proPO-AE
      (De Gregorio et al., 2002)
      sp7
      (Xu et al., 2016, Chambers et al., 2014, Winterhalter and Fedorka, 2009)
      Name Synonyms
      Melanization Protease 2
      (Tang et al., 2006, Tang et al., 2006)
      Serine protease 7
      (Ordan and Volk, 2016, Xu et al., 2016, Clark et al., 2011)
      Serine protease-7
      (Castillo et al., 2015)
      prophenoloxidase-activating enzyme
      (Leclerc et al., 2006)
      prophenoloxidase-activating enzyme 1
      (Vlisidou and Wood, 2015)
      serine protease 7
      (Yadav et al., 2017, Marshall and Sinclair, 2010, Winterhalter and Fedorka, 2009)
      Secondary FlyBase IDs
      • FBgn0040241
      Datasets (0)
      Study focus (0)
      Experimental Role
      Project
      Project Type
      Title
      References (87)