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Gene Dmel\Ada2b

General Information
Symbol	Dmel\Ada2b	Species	D. melanogaster
Name	transcriptional Adaptor 2b	Annotation symbol	CG9638
Feature type	protein_coding_gene	FlyBase ID	FBgn0037555
Gene Model Status	Current	Stock availability	5 publicly available
Also Known As	dAda2b
Genomic Location
Chromosome (arm)	3R	Recombination map
Cytogenetic map	84F5-84F5	Sequence location	3R:4,062,354..4,066,237 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene transcriptional Adaptor 2b is referred to in FlyBase by the symbol Dmel\Ada2b (CG9638, FBgn0037555). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: protein binding. There is experimental evidence that it is involved in the biological process: positive regulation of histone acetylation; histone H3 acetylation; regulation of transcription, DNA-dependent; axon target recognition; wing disc pattern formation; chromatin remodeling. 19 alleles are reported. The phenotypes of these alleles are annotated with: glial cell; trichogen cell. It has 3 annotated transcripts and 3 annotated polypeptides. Protein features are: Homeodomain-like; SANT domain; SANT/Myb domain; Transcriptional adaptor 2; Zinc finger, ZZ-type. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderate expression. Peak expression observed within 00-06 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval central nervous system, larval Malpighian tubules, larval/adult salivary gland, adult ovary. Comments on Affy2 ProbeSet: ProbeSet 1623806_at completely aligns to an exonic region common to each of the 2 FlyBase-annotated transcript isoforms of Ada2b. Gene sequence location is 3R:4062354..4066237.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03	Alleles Ada2b[Scer\UAS.cVa] Transgenic Constructs M{UAS-Ada2b.V} M{UAS-Ada2a::Ada2b} M{UAS-Ada2bM::Ada2a} M{UAS-Ada2bL::Ada2a} M{UAS-Ada2bS::Ada2a}
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 84F5-84F5   Limits computationally determined from genome sequence between P{PZ}grn05930 and P{PZ}Mcm2rL074
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Ada2b for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Multiphase exon postulated: exon reading frame differs in alternative transcripts. Gene model reviewed during 5.47 Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Ada2b-RA FBtr0081807  NM_141516   2154   418 Ada2b-RB FBtr0100368  NM_001031980   2084   555 Ada2b-RC FBtr0334315  NM_001275438   2636   418
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Ada2b-PA   FBpp0081303   48.3   418   9.02     NP_649773   AAF54199 Ada2b-PB   FBpp0099776   62.0   555   7.09     NP_001027151   AAZ52519 Ada2b-PC   FBpp0306430   48.3   418   9.02     NP_001262367   AGB95749
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Zinc finger, ZZ-type (IPR000433) SANT/Myb domain (IPR001005) Homeodomain-like (IPR009057) Transcriptional adaptor 2 (IPR016827) SANT domain (IPR017884)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA202098   AA264937   AA391542   AA438605   AA439721   AA802382   AA816695   AA820681   AA941621   AA949533   AA949721   AE014297 AAF54199   AE014297 AAZ52519   AE014297 AGB95749   AI455492   AI456860   AI515114   AI518372   AY058546 AAL13775   AY142213 AAN52141   BF486940   BF505866   BF505877   BI170054   BI171009   BI173955   BI213896   BI215840   BI231747   BI232982   BI240291   BI356490   BI362930   BI567290   CO178327   CO264496   CO275220   CO299232   CO302857   CO305769   CO308301   CO308883   CO312401   CO328212   CO330700   EC058310   EC074467   EC077667   EC078987   EC080033   EC087698   EC232961   EC235461   EC249615   EV574932   EV579848   EV581948   EV583655   EV592295   EV592522   EV593864   EV600184
UniProtKB/Swiss-Prot	Q8I8V0
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 3   organism   (Fisher et al., 2012) Comment:maternally deposited embryonic stage 4 -- 6   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 7 -- 8   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 9 -- 10   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 11 -- 12   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 13 -- 16   embryonic brain   (Fisher et al., 2012) embryonic/larval midgut   (Fisher et al., 2012) ventral nerve cord   (Fisher et al., 2012)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
nucleus inferred from direct assay (Weake et al., 2011, Guelman et al., 2006) inferred from direct assay (assigned by UniProtKB) (Muratoglu et al., 2003) polytene chromosome inferred from direct assay (Muratoglu et al., 2003, Kusch et al., 2003, Nagy et al., 2010) SAGA complex inferred from direct assay (Weake et al., 2011, Guelman et al., 2006) inferred from physical interaction with Nipped-A AND inferred from physical interaction with Spt3 (Kusch et al., 2003)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval central nervous system, larval Malpighian tubules, larval/adult salivary gland, adult ovary. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    116.95 Larval Midgut    62.9 Larval Hindgut    79.3 Larval Malpighian Tubules    118.7 Larval Fat Body    55.9 Larval Salivary Gland    113.6 Larval Trachea    79.1 Larval Carcass    71.95 Adult Head    45.3 Adult Eye    35.275 Adult Brain    76.7 Adult Thoracic-Abdominal Ganglion    48.8 Adult Crop    57.9 Adult Midgut    69.2 Adult Hindgut    64.3 Adult Malpighian Tubules    83.5 Adult Fat Body    60 Adult Salivary Gland    102.2 Adult Heart    43.875 Adult VirginFemale Spermatheca    50.6 Adult InseminatedFemale Spermatheca    37 Adult Ovary    363.8 Adult Testis    37.1 Adult Male Accessory Gland    66.1 Adult Carcass    50.5 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    116.95 Larval Midgut    62.9 Larval Hindgut    79.3 Larval Malpighian Tubules    118.7 Larval Fat Body    55.9 Larval Salivary Gland    113.6 Larval Trachea    79.1 Larval Carcass    71.95 Adult Head    45.3 Adult Eye    35.275 Adult Brain    76.7 Adult Thoracic-Abdominal Ganglion    48.8 Adult Crop    57.9 Adult Midgut    69.2 Adult Hindgut    64.3 Adult Malpighian Tubules    83.5 Adult Fat Body    60 Adult Salivary Gland    102.2 Adult Heart    43.875 Adult VirginFemale Spermatheca    50.6 Adult InseminatedFemale Spermatheca    37 Adult Ovary    363.8 Adult Testis    37.1 Adult Male Accessory Gland    66.1 Adult Carcass    50.5 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    116.95 Larval Midgut    62.9 Larval Hindgut    79.3 Larval Malpighian Tubules    118.7 Larval Fat Body    55.9 Larval Salivary Gland    113.6 Larval Trachea    79.1 Larval Carcass    71.95 Adult Head    45.3 Adult Eye    35.275 Adult Brain    76.7 Adult Thoracic-Abdominal Ganglion    48.8 Adult Crop    57.9 Adult Midgut    69.2 Adult Hindgut    64.3 Adult Malpighian Tubules    83.5 Adult Fat Body    60 Adult Salivary Gland    102.2 Adult Heart    43.875 Adult VirginFemale Spermatheca    50.6 Adult InseminatedFemale Spermatheca    37 Adult Ovary    363.8 Adult Testis    37.1 Adult Male Accessory Gland    66.1 Adult Carcass    50.5 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    116.95 Larval Midgut    62.9 Larval Hindgut    79.3 Larval Malpighian Tubules    118.7 Larval Fat Body    55.9 Larval Salivary Gland    113.6 Larval Trachea    79.1 Larval Carcass    71.95 Adult Head    45.3 Adult Eye    35.275 Adult Brain    76.7 Adult Thoracic-Abdominal Ganglion    48.8 Adult Crop    57.9 Adult Midgut    69.2 Adult Hindgut    64.3 Adult Malpighian Tubules    83.5 Adult Fat Body    60 Adult Salivary Gland    102.2 Adult Heart    43.875 Adult VirginFemale Spermatheca    50.6 Adult InseminatedFemale Spermatheca    37 Adult Ovary    363.8 Adult Testis    37.1 Adult Male Accessory Gland    66.1 Adult Carcass    50.5 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    116.95 Larval Midgut    62.9 Larval Hindgut    79.3 Larval Malpighian Tubules    118.7 Larval Fat Body    55.9 Larval Salivary Gland    113.6 Larval Trachea    79.1 Larval Carcass    71.95 Adult Head    45.3 Adult Eye    35.275 Adult Brain    76.7 Adult Thoracic-Abdominal Ganglion    48.8 Adult Crop    57.9 Adult Midgut    69.2 Adult Hindgut    64.3 Adult Malpighian Tubules    83.5 Adult Fat Body    60 Adult Salivary Gland    102.2 Adult Heart    43.875 Adult VirginFemale Spermatheca    50.6 Adult InseminatedFemale Spermatheca    37 Adult Ovary    363.8 Adult Testis    37.1 Adult Male Accessory Gland    66.1 Adult Carcass    50.5 Expression Level Scale  None   Low   Moderate   High  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    116.95 Larval Midgut    62.9 Larval Hindgut    79.3 Larval Malpighian Tubules    118.7 Larval Fat Body    55.9 Larval Salivary Gland    113.6 Larval Trachea    79.1 Larval Carcass    71.95 Adult Head    45.3 Adult Eye    35.275 Adult Brain    76.7 Adult Thoracic-Abdominal Ganglion    48.8 Adult Crop    57.9 Adult Midgut    69.2 Adult Hindgut    64.3 Adult Malpighian Tubules    83.5 Adult Fat Body    60 Adult Salivary Gland    102.2 Adult Heart    43.875 Adult VirginFemale Spermatheca    50.6 Adult InseminatedFemale Spermatheca    37 Adult Ovary    363.8 Adult Testis    37.1 Adult Male Accessory Gland    66.1 Adult Carcass    50.5 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    116.95 Larval Midgut    62.9 Larval Hindgut    79.3 Larval Malpighian Tubules    118.7 Larval Fat Body    55.9 Larval Salivary Gland    113.6 Larval Trachea    79.1 Larval Carcass    71.95 Adult Head    45.3 Adult Eye    35.275 Adult Brain    76.7 Adult Thoracic-Abdominal Ganglion    48.8 Adult Crop    57.9 Adult Midgut    69.2 Adult Hindgut    64.3 Adult Malpighian Tubules    83.5 Adult Fat Body    60 Adult Salivary Gland    102.2 Adult Heart    43.875 Adult VirginFemale Spermatheca    50.6 Adult InseminatedFemale Spermatheca    37 Adult Ovary    363.8 Adult Testis    37.1 Adult Male Accessory Gland    66.1 Adult Carcass    50.5 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    116.95 Larval Midgut    62.9 Larval Hindgut    79.3 Larval Malpighian Tubules    118.7 Larval Fat Body    55.9 Larval Salivary Gland    113.6 Larval Trachea    79.1 Larval Carcass    71.95 Adult Head    45.3 Adult Eye    35.275 Adult Brain    76.7 Adult Thoracic-Abdominal Ganglion    48.8 Adult Crop    57.9 Adult Midgut    69.2 Adult Hindgut    64.3 Adult Malpighian Tubules    83.5 Adult Fat Body    60 Adult Salivary Gland    102.2 Adult Heart    43.875 Adult VirginFemale Spermatheca    50.6 Adult InseminatedFemale Spermatheca    37 Adult Ovary    363.8 Adult Testis    37.1 Adult Male Accessory Gland    66.1 Adult Carcass    50.5 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    45.3   NA  Eye    35.275   NA  Brain    76.7   116.95  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    48.8   NA  Crop    57.9   62.9  Midgut    69.2   79.3  Hindgut    64.3   118.7  Malpighian Tubules    83.5   55.9  Fat Body    60   113.6  Salivary Gland    102.2   NA  Heart    43.875   79.1  Trachea    NA   NA  VirginFemale Spermatheca    50.6   NA  InseminatedFemale Spermatheca    37   NA  Ovary    363.8   NA  Testis    37.1   NA  Male Accessory Gland    66.1   71.95  Carcass    50.5 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    19 central nervous system, larvae L3    28 central nervous system, pupae P8    13 head, virgin 1-day female    6 head, virgin 4-day female    6 head, virgin 20-day female    9 head, mated 1-day female    7 head, mated 4-day female    6 head, mated 20-day female    8 head, mated 1-day male    8 head, mated 4-day male    12 head, mated 20-day male    15 salivary gland, larvae L3 wandering    6 salivary gland, white prepupae    17 digestive system, larvae L3 wandering    18 digestive system, 1-day adult    10 digestive system, 4-day adult    13 digestive system, 20-day adult    13 fat body, larvae L3 wandering    8 fat body, white prepupae    11 fat body, pupae P8    6 carcass, larvae L3 wandering    21 carcass, 1-day adult    7 carcass, 4-day adult    10 carcass, 20-day adult    10 ovary, virgin 4-day female    95 ovary, mated 4-day female    107 testis, mated 4-day male    10 accessory gland, mated 4-day male    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    19 central nervous system, larvae L3  (28) central nervous system, pupae P8    13 head, virgin 1-day female    6 head, virgin 4-day female    6 head, virgin 20-day female    9 head, mated 1-day female    7 head, mated 4-day female    6 head, mated 20-day female    8 head, mated 1-day male    8 head, mated 4-day male    12 head, mated 20-day male    15 salivary gland, larvae L3 wandering    6 salivary gland, white prepupae    17 digestive system, larvae L3 wandering    18 digestive system, 1-day adult    10 digestive system, 4-day adult    13 digestive system, 20-day adult    13 fat body, larvae L3 wandering    8 fat body, white prepupae    11 fat body, pupae P8    6 carcass, larvae L3 wandering    21 carcass, 1-day adult    7 carcass, 4-day adult    10 carcass, 20-day adult    10 ovary, virgin 4-day female  (95) ovary, mated 4-day female  (107) testis, mated 4-day male    10 accessory gland, mated 4-day male    5 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    19 central nervous system, larvae L3    28 central nervous system, pupae P8    13 head, virgin 1-day female    6 head, virgin 4-day female    6 head, virgin 20-day female    9 head, mated 1-day female    7 head, mated 4-day female    6 head, mated 20-day female    8 head, mated 1-day male    8 head, mated 4-day male    12 head, mated 20-day male    15 salivary gland, larvae L3 wandering    6 salivary gland, white prepupae    17 digestive system, larvae L3 wandering    18 digestive system, 1-day adult    10 digestive system, 4-day adult    13 digestive system, 20-day adult    13 fat body, larvae L3 wandering    8 fat body, white prepupae    11 fat body, pupae P8    6 carcass, larvae L3 wandering    21 carcass, 1-day adult    7 carcass, 4-day adult    10 carcass, 20-day adult    10 ovary, virgin 4-day female    95 ovary, mated 4-day female  107 testis, mated 4-day male    10 accessory gland, mated 4-day male    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    19 central nervous system, larvae L3    28 central nervous system, pupae P8    13 head, virgin 1-day female    6 head, virgin 4-day female    6 head, virgin 20-day female    9 head, mated 1-day female    7 head, mated 4-day female    6 head, mated 20-day female    8 head, mated 1-day male    8 head, mated 4-day male    12 head, mated 20-day male    15 salivary gland, larvae L3 wandering    6 salivary gland, white prepupae    17 digestive system, larvae L3 wandering    18 digestive system, 1-day adult    10 digestive system, 4-day adult    13 digestive system, 20-day adult    13 fat body, larvae L3 wandering    8 fat body, white prepupae    11 fat body, pupae P8    6 carcass, larvae L3 wandering    21 carcass, 1-day adult    7 carcass, 4-day adult    10 carcass, 20-day adult    10 ovary, virgin 4-day female    95 ovary, mated 4-day female    107 testis, mated 4-day male    10 accessory gland, mated 4-day male    5 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    19 central nervous system, larvae L3    28 central nervous system, pupae P8    13 head, virgin 1-day female    6 head, virgin 4-day female    6 head, virgin 20-day female    9 head, mated 1-day female    7 head, mated 4-day female    6 head, mated 20-day female    8 head, mated 1-day male    8 head, mated 4-day male    12 head, mated 20-day male    15 salivary gland, larvae L3 wandering    6 salivary gland, white prepupae    17 digestive system, larvae L3 wandering    18 digestive system, 1-day adult    10 digestive system, 4-day adult    13 digestive system, 20-day adult    13 fat body, larvae L3 wandering    8 fat body, white prepupae    11 fat body, pupae P8    6 carcass, larvae L3 wandering    21 carcass, 1-day adult    7 carcass, 4-day adult    10 carcass, 20-day adult    10 ovary, virgin 4-day female    95 ovary, mated 4-day female    107 testis, mated 4-day male    10 accessory gland, mated 4-day male    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    19 central nervous system, larvae L3  28 central nervous system, pupae P8    13 head, virgin 1-day female    6 head, virgin 4-day female    6 head, virgin 20-day female    9 head, mated 1-day female    7 head, mated 4-day female    6 head, mated 20-day female    8 head, mated 1-day male    8 head, mated 4-day male    12 head, mated 20-day male    15 salivary gland, larvae L3 wandering    6 salivary gland, white prepupae    17 digestive system, larvae L3 wandering    18 digestive system, 1-day adult    10 digestive system, 4-day adult    13 digestive system, 20-day adult    13 fat body, larvae L3 wandering    8 fat body, white prepupae    11 fat body, pupae P8    6 carcass, larvae L3 wandering    21 carcass, 1-day adult    7 carcass, 4-day adult    10 carcass, 20-day adult    10 ovary, virgin 4-day female  (95) ovary, mated 4-day female  (107) testis, mated 4-day male    10 accessory gland, mated 4-day male    5 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    19 central nervous system, larvae L3    28 central nervous system, pupae P8    13 head, virgin 1-day female    6 head, virgin 4-day female    6 head, virgin 20-day female    9 head, mated 1-day female    7 head, mated 4-day female    6 head, mated 20-day female    8 head, mated 1-day male    8 head, mated 4-day male    12 head, mated 20-day male    15 salivary gland, larvae L3 wandering    6 salivary gland, white prepupae    17 digestive system, larvae L3 wandering    18 digestive system, 1-day adult    10 digestive system, 4-day adult    13 digestive system, 20-day adult    13 fat body, larvae L3 wandering    8 fat body, white prepupae    11 fat body, pupae P8    6 carcass, larvae L3 wandering    21 carcass, 1-day adult    7 carcass, 4-day adult    10 carcass, 20-day adult    10 ovary, virgin 4-day female    95 ovary, mated 4-day female  107 testis, mated 4-day male    10 accessory gland, mated 4-day male    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    19 central nervous system, larvae L3    28 central nervous system, pupae P8    13 head, virgin 1-day female    6 head, virgin 4-day female    6 head, virgin 20-day female    9 head, mated 1-day female    7 head, mated 4-day female    6 head, mated 20-day female    8 head, mated 1-day male    8 head, mated 4-day male    12 head, mated 20-day male    15 salivary gland, larvae L3 wandering    6 salivary gland, white prepupae    17 digestive system, larvae L3 wandering    18 digestive system, 1-day adult    10 digestive system, 4-day adult    13 digestive system, 20-day adult    13 fat body, larvae L3 wandering    8 fat body, white prepupae    11 fat body, pupae P8    6 carcass, larvae L3 wandering    21 carcass, 1-day adult    7 carcass, 4-day adult    10 carcass, 20-day adult    10 ovary, virgin 4-day female    95 ovary, mated 4-day female    107 testis, mated 4-day male    10 accessory gland, mated 4-day male    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderate expression. Peak expression observed within 00-06 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    149 embryo 02-04hr    81 embryo 04-06hr    52 embryo 06-08hr    47 embryo 08-10hr    45 embryo 10-12hr    33 embryo 12-14hr    26 embryo 14-16hr    27 embryo 16-18hr    21 embryo 18-20hr    15 embryo 20-22hr    23 embryo 22-24hr    19 larva L1    11 larva L2    8 larva L3 12hr old    9 larva L3 puffstage 1-2    13 larva L3 puffstage 3-6    22 larva L3 puffstage 7-9    21 white prepupae new    23 white prepupae 12hr    25 white prepupae 24hr    24 pupae 2d postWPP    15 pupae 3d postWPP    9 pupae 4d postWPP    9 adult male 01day    9 adult male 05day    11 adult male 30day    12 adult female 01day    43 adult female 05day    84 adult female 30day    87 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (149) embryo 02-04hr  (81) embryo 04-06hr  (52) embryo 06-08hr  (47) embryo 08-10hr  (45) embryo 10-12hr  (33) embryo 12-14hr  26 embryo 14-16hr  (27) embryo 16-18hr    21 embryo 18-20hr    15 embryo 20-22hr    23 embryo 22-24hr    19 larva L1    11 larva L2    8 larva L3 12hr old    9 larva L3 puffstage 1-2    13 larva L3 puffstage 3-6    22 larva L3 puffstage 7-9    21 white prepupae new    23 white prepupae 12hr    25 white prepupae 24hr    24 pupae 2d postWPP    15 pupae 3d postWPP    9 pupae 4d postWPP    9 adult male 01day    9 adult male 05day    11 adult male 30day    12 adult female 01day  (43) adult female 05day  (84) adult female 30day  (87) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  (149) embryo 02-04hr    81 embryo 04-06hr    52 embryo 06-08hr    47 embryo 08-10hr    45 embryo 10-12hr    33 embryo 12-14hr    26 embryo 14-16hr    27 embryo 16-18hr    21 embryo 18-20hr    15 embryo 20-22hr    23 embryo 22-24hr    19 larva L1    11 larva L2    8 larva L3 12hr old    9 larva L3 puffstage 1-2    13 larva L3 puffstage 3-6    22 larva L3 puffstage 7-9    21 white prepupae new    23 white prepupae 12hr    25 white prepupae 24hr    24 pupae 2d postWPP    15 pupae 3d postWPP    9 pupae 4d postWPP    9 adult male 01day    9 adult male 05day    11 adult male 30day    12 adult female 01day    43 adult female 05day    84 adult female 30day    87 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    149 embryo 02-04hr    81 embryo 04-06hr    52 embryo 06-08hr    47 embryo 08-10hr    45 embryo 10-12hr    33 embryo 12-14hr    26 embryo 14-16hr    27 embryo 16-18hr    21 embryo 18-20hr    15 embryo 20-22hr    23 embryo 22-24hr    19 larva L1    11 larva L2    8 larva L3 12hr old    9 larva L3 puffstage 1-2    13 larva L3 puffstage 3-6    22 larva L3 puffstage 7-9    21 white prepupae new    23 white prepupae 12hr    25 white prepupae 24hr    24 pupae 2d postWPP    15 pupae 3d postWPP    9 pupae 4d postWPP    9 adult male 01day    9 adult male 05day    11 adult male 30day    12 adult female 01day    43 adult female 05day    84 adult female 30day    87 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    149 embryo 02-04hr    81 embryo 04-06hr    52 embryo 06-08hr    47 embryo 08-10hr    45 embryo 10-12hr    33 embryo 12-14hr    26 embryo 14-16hr    27 embryo 16-18hr    21 embryo 18-20hr    15 embryo 20-22hr    23 embryo 22-24hr    19 larva L1    11 larva L2    8 larva L3 12hr old    9 larva L3 puffstage 1-2    13 larva L3 puffstage 3-6    22 larva L3 puffstage 7-9    21 white prepupae new    23 white prepupae 12hr    25 white prepupae 24hr    24 pupae 2d postWPP    15 pupae 3d postWPP    9 pupae 4d postWPP    9 adult male 01day    9 adult male 05day    11 adult male 30day    12 adult female 01day    43 adult female 05day    84 adult female 30day    87 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (149) embryo 02-04hr  (81) embryo 04-06hr  (52) embryo 06-08hr  (47) embryo 08-10hr  (45) embryo 10-12hr  (33) embryo 12-14hr  26 embryo 14-16hr  27 embryo 16-18hr    21 embryo 18-20hr    15 embryo 20-22hr    23 embryo 22-24hr    19 larva L1    11 larva L2    8 larva L3 12hr old    9 larva L3 puffstage 1-2    13 larva L3 puffstage 3-6    22 larva L3 puffstage 7-9    21 white prepupae new    23 white prepupae 12hr    25 white prepupae 24hr    24 pupae 2d postWPP    15 pupae 3d postWPP    9 pupae 4d postWPP    9 adult male 01day    9 adult male 05day    11 adult male 30day    12 adult female 01day  (43) adult female 05day  (84) adult female 30day  (87) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  (149) embryo 02-04hr    81 embryo 04-06hr    52 embryo 06-08hr    47 embryo 08-10hr    45 embryo 10-12hr    33 embryo 12-14hr    26 embryo 14-16hr    27 embryo 16-18hr    21 embryo 18-20hr    15 embryo 20-22hr    23 embryo 22-24hr    19 larva L1    11 larva L2    8 larva L3 12hr old    9 larva L3 puffstage 1-2    13 larva L3 puffstage 3-6    22 larva L3 puffstage 7-9    21 white prepupae new    23 white prepupae 12hr    25 white prepupae 24hr    24 pupae 2d postWPP    15 pupae 3d postWPP    9 pupae 4d postWPP    9 adult male 01day    9 adult male 05day    11 adult male 30day    12 adult female 01day    43 adult female 05day    84 adult female 30day    87 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    149 embryo 02-04hr    81 embryo 04-06hr    52 embryo 06-08hr    47 embryo 08-10hr    45 embryo 10-12hr    33 embryo 12-14hr    26 embryo 14-16hr    27 embryo 16-18hr    21 embryo 18-20hr    15 embryo 20-22hr    23 embryo 22-24hr    19 larva L1    11 larva L2    8 larva L3 12hr old    9 larva L3 puffstage 1-2    13 larva L3 puffstage 3-6    22 larva L3 puffstage 7-9    21 white prepupae new    23 white prepupae 12hr    25 white prepupae 24hr    24 pupae 2d postWPP    15 pupae 3d postWPP    9 pupae 4d postWPP    9 adult male 01day    9 adult male 05day    11 adult male 30day    12 adult female 01day    43 adult female 05day    84 adult female 30day    87 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    22 Schneider line 2 Sg4    21 embryonic 1182-4H    40 embryonic GM2    24 embryonic Kc167    28 embryonic S1    25 embryonic S3    12 leg disc CME L1    27 wing disc CME-W2    28 wing disc ML-DmD8    24 wing disc ML-DmD9    30 wing disc ML-DmD16-c3    29 wing disc ML-DmD21    27 wing disc ML-DmD32    39 haltere disc ML-DmD17-c3    25 eye-antennal disc ML-DmD11    46 antennal disc ML-DmD20-c5    28 mixed discs ML-DmD4-c1    26 CNS ML-DmBG1-c1    40 CNS ML-DmBG2-c2    18 tumorous blood cells mbn2    13 ovary fGS/OSS    32 ovary OSC    34 ovary OSS    29 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    22 Schneider line 2 Sg4    21 embryonic 1182-4H  (40) embryonic GM2    24 embryonic Kc167  (28) embryonic S1    25 embryonic S3    12 leg disc CME L1  (27) wing disc CME-W2  (28) wing disc ML-DmD8    24 wing disc ML-DmD9  (30) wing disc ML-DmD16-c3  (29) wing disc ML-DmD21  (27) wing disc ML-DmD32  (39) haltere disc ML-DmD17-c3    25 eye-antennal disc ML-DmD11  (46) antennal disc ML-DmD20-c5  (28) mixed discs ML-DmD4-c1  26 CNS ML-DmBG1-c1  (40) CNS ML-DmBG2-c2    18 tumorous blood cells mbn2    13 ovary fGS/OSS  (32) ovary OSC  (34) ovary OSS  (29) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    22 Schneider line 2 Sg4    21 embryonic 1182-4H    40 embryonic GM2    24 embryonic Kc167    28 embryonic S1    25 embryonic S3    12 leg disc CME L1    27 wing disc CME-W2    28 wing disc ML-DmD8    24 wing disc ML-DmD9    30 wing disc ML-DmD16-c3    29 wing disc ML-DmD21    27 wing disc ML-DmD32    39 haltere disc ML-DmD17-c3    25 eye-antennal disc ML-DmD11    46 antennal disc ML-DmD20-c5    28 mixed discs ML-DmD4-c1    26 CNS ML-DmBG1-c1    40 CNS ML-DmBG2-c2    18 tumorous blood cells mbn2    13 ovary fGS/OSS    32 ovary OSC    34 ovary OSS    29 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    22 Schneider line 2 Sg4    21 embryonic 1182-4H    40 embryonic GM2    24 embryonic Kc167    28 embryonic S1    25 embryonic S3    12 leg disc CME L1    27 wing disc CME-W2    28 wing disc ML-DmD8    24 wing disc ML-DmD9    30 wing disc ML-DmD16-c3    29 wing disc ML-DmD21    27 wing disc ML-DmD32    39 haltere disc ML-DmD17-c3    25 eye-antennal disc ML-DmD11    46 antennal disc ML-DmD20-c5    28 mixed discs ML-DmD4-c1    26 CNS ML-DmBG1-c1    40 CNS ML-DmBG2-c2    18 tumorous blood cells mbn2    13 ovary fGS/OSS    32 ovary OSC    34 ovary OSS    29 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    22 Schneider line 2 Sg4    21 embryonic 1182-4H    40 embryonic GM2    24 embryonic Kc167    28 embryonic S1    25 embryonic S3    12 leg disc CME L1    27 wing disc CME-W2    28 wing disc ML-DmD8    24 wing disc ML-DmD9    30 wing disc ML-DmD16-c3    29 wing disc ML-DmD21    27 wing disc ML-DmD32    39 haltere disc ML-DmD17-c3    25 eye-antennal disc ML-DmD11    46 antennal disc ML-DmD20-c5    28 mixed discs ML-DmD4-c1    26 CNS ML-DmBG1-c1    40 CNS ML-DmBG2-c2    18 tumorous blood cells mbn2    13 ovary fGS/OSS    32 ovary OSC    34 ovary OSS    29 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    22 Schneider line 2 Sg4    21 embryonic 1182-4H  (40) embryonic GM2    24 embryonic Kc167  28 embryonic S1    25 embryonic S3    12 leg disc CME L1  27 wing disc CME-W2  28 wing disc ML-DmD8    24 wing disc ML-DmD9  30 wing disc ML-DmD16-c3  29 wing disc ML-DmD21  27 wing disc ML-DmD32  (39) haltere disc ML-DmD17-c3    25 eye-antennal disc ML-DmD11  (46) antennal disc ML-DmD20-c5  28 mixed discs ML-DmD4-c1  26 CNS ML-DmBG1-c1  (40) CNS ML-DmBG2-c2    18 tumorous blood cells mbn2    13 ovary fGS/OSS  32 ovary OSC  (34) ovary OSS  29 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    22 Schneider line 2 Sg4    21 embryonic 1182-4H    40 embryonic GM2    24 embryonic Kc167    28 embryonic S1    25 embryonic S3    12 leg disc CME L1    27 wing disc CME-W2    28 wing disc ML-DmD8    24 wing disc ML-DmD9    30 wing disc ML-DmD16-c3    29 wing disc ML-DmD21    27 wing disc ML-DmD32    39 haltere disc ML-DmD17-c3    25 eye-antennal disc ML-DmD11    46 antennal disc ML-DmD20-c5    28 mixed discs ML-DmD4-c1    26 CNS ML-DmBG1-c1    40 CNS ML-DmBG2-c2    18 tumorous blood cells mbn2    13 ovary fGS/OSS    32 ovary OSC    34 ovary OSS    29 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    22 Schneider line 2 Sg4    21 embryonic 1182-4H    40 embryonic GM2    24 embryonic Kc167    28 embryonic S1    25 embryonic S3    12 leg disc CME L1    27 wing disc CME-W2    28 wing disc ML-DmD8    24 wing disc ML-DmD9    30 wing disc ML-DmD16-c3    29 wing disc ML-DmD21    27 wing disc ML-DmD32    39 haltere disc ML-DmD17-c3    25 eye-antennal disc ML-DmD11    46 antennal disc ML-DmD20-c5    28 mixed discs ML-DmD4-c1    26 CNS ML-DmBG1-c1    40 CNS ML-DmBG2-c2    18 tumorous blood cells mbn2    13 ovary fGS/OSS    32 ovary OSC    34 ovary OSS    29 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    38 cold shock, 4-day adult    18 heat shock, 4-day adult    30 Cadmium 50 mM 6 hrs, larvae L3    10 Cadmium 50 mM 12 hrs, larvae L3    14 Cadmium 50 mM 48 hrs, 4-day adult    31 Cadmium 100 mM 48 hrs, 4-day adult    70 Copper 0.5 mM 12 hrs, larvae L3    16 Copper 15 mM 48 hrs, 4-day adult    43 Zinc 5 mM 12 hrs, larvae L3    11 Zinc 4.5 mM 48 hrs, 4-day adult    20 Ethanol 2.5% 3 hrs, larvae L3    68 Ethanol 5% 3 hrs, larvae L3    20 Ethanol 10% 3 hrs, larvae L3    12 Caffeine 1.5 mg/ml 4 hrs, larvae L3    19 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    69 Caffeine 25 mg/ml 48 hrs, 4-day adult    34 Paraquat 5 mM 48 hrs, 4-day adult    51 Paraquat 10 mM 48 hrs, 4-day adult    47 Rotenone 2 μg 12 hrs, larvae L3    12 Rotenone 8 μg 12 hrs, larvae L3    12 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (38) cold shock, 4-day adult    18 heat shock, 4-day adult  (30) Cadmium 50 mM 6 hrs, larvae L3    10 Cadmium 50 mM 12 hrs, larvae L3    14 Cadmium 50 mM 48 hrs, 4-day adult  (31) Cadmium 100 mM 48 hrs, 4-day adult  (70) Copper 0.5 mM 12 hrs, larvae L3    16 Copper 15 mM 48 hrs, 4-day adult  (43) Zinc 5 mM 12 hrs, larvae L3    11 Zinc 4.5 mM 48 hrs, 4-day adult    20 Ethanol 2.5% 3 hrs, larvae L3  (68) Ethanol 5% 3 hrs, larvae L3    20 Ethanol 10% 3 hrs, larvae L3    12 Caffeine 1.5 mg/ml 4 hrs, larvae L3    19 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (69) Caffeine 25 mg/ml 48 hrs, 4-day adult  (34) Paraquat 5 mM 48 hrs, 4-day adult  (51) Paraquat 10 mM 48 hrs, 4-day adult  (47) Rotenone 2 μg 12 hrs, larvae L3    12 Rotenone 8 μg 12 hrs, larvae L3    12 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    38 cold shock, 4-day adult    18 heat shock, 4-day adult    30 Cadmium 50 mM 6 hrs, larvae L3    10 Cadmium 50 mM 12 hrs, larvae L3    14 Cadmium 50 mM 48 hrs, 4-day adult    31 Cadmium 100 mM 48 hrs, 4-day adult    70 Copper 0.5 mM 12 hrs, larvae L3    16 Copper 15 mM 48 hrs, 4-day adult    43 Zinc 5 mM 12 hrs, larvae L3    11 Zinc 4.5 mM 48 hrs, 4-day adult    20 Ethanol 2.5% 3 hrs, larvae L3    68 Ethanol 5% 3 hrs, larvae L3    20 Ethanol 10% 3 hrs, larvae L3    12 Caffeine 1.5 mg/ml 4 hrs, larvae L3    19 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    69 Caffeine 25 mg/ml 48 hrs, 4-day adult    34 Paraquat 5 mM 48 hrs, 4-day adult    51 Paraquat 10 mM 48 hrs, 4-day adult    47 Rotenone 2 μg 12 hrs, larvae L3    12 Rotenone 8 μg 12 hrs, larvae L3    12 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    38 cold shock, 4-day adult    18 heat shock, 4-day adult    30 Cadmium 50 mM 6 hrs, larvae L3    10 Cadmium 50 mM 12 hrs, larvae L3    14 Cadmium 50 mM 48 hrs, 4-day adult    31 Cadmium 100 mM 48 hrs, 4-day adult    70 Copper 0.5 mM 12 hrs, larvae L3    16 Copper 15 mM 48 hrs, 4-day adult    43 Zinc 5 mM 12 hrs, larvae L3    11 Zinc 4.5 mM 48 hrs, 4-day adult    20 Ethanol 2.5% 3 hrs, larvae L3    68 Ethanol 5% 3 hrs, larvae L3    20 Ethanol 10% 3 hrs, larvae L3    12 Caffeine 1.5 mg/ml 4 hrs, larvae L3    19 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    69 Caffeine 25 mg/ml 48 hrs, 4-day adult    34 Paraquat 5 mM 48 hrs, 4-day adult    51 Paraquat 10 mM 48 hrs, 4-day adult    47 Rotenone 2 μg 12 hrs, larvae L3    12 Rotenone 8 μg 12 hrs, larvae L3    12 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    38 cold shock, 4-day adult    18 heat shock, 4-day adult    30 Cadmium 50 mM 6 hrs, larvae L3    10 Cadmium 50 mM 12 hrs, larvae L3    14 Cadmium 50 mM 48 hrs, 4-day adult    31 Cadmium 100 mM 48 hrs, 4-day adult    70 Copper 0.5 mM 12 hrs, larvae L3    16 Copper 15 mM 48 hrs, 4-day adult    43 Zinc 5 mM 12 hrs, larvae L3    11 Zinc 4.5 mM 48 hrs, 4-day adult    20 Ethanol 2.5% 3 hrs, larvae L3    68 Ethanol 5% 3 hrs, larvae L3    20 Ethanol 10% 3 hrs, larvae L3    12 Caffeine 1.5 mg/ml 4 hrs, larvae L3    19 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    69 Caffeine 25 mg/ml 48 hrs, 4-day adult    34 Paraquat 5 mM 48 hrs, 4-day adult    51 Paraquat 10 mM 48 hrs, 4-day adult    47 Rotenone 2 μg 12 hrs, larvae L3    12 Rotenone 8 μg 12 hrs, larvae L3    12 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (38) cold shock, 4-day adult    18 heat shock, 4-day adult  30 Cadmium 50 mM 6 hrs, larvae L3    10 Cadmium 50 mM 12 hrs, larvae L3    14 Cadmium 50 mM 48 hrs, 4-day adult  31 Cadmium 100 mM 48 hrs, 4-day adult  (70) Copper 0.5 mM 12 hrs, larvae L3    16 Copper 15 mM 48 hrs, 4-day adult  (43) Zinc 5 mM 12 hrs, larvae L3    11 Zinc 4.5 mM 48 hrs, 4-day adult    20 Ethanol 2.5% 3 hrs, larvae L3  (68) Ethanol 5% 3 hrs, larvae L3    20 Ethanol 10% 3 hrs, larvae L3    12 Caffeine 1.5 mg/ml 4 hrs, larvae L3    19 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (69) Caffeine 25 mg/ml 48 hrs, 4-day adult  (34) Paraquat 5 mM 48 hrs, 4-day adult  (51) Paraquat 10 mM 48 hrs, 4-day adult  (47) Rotenone 2 μg 12 hrs, larvae L3    12 Rotenone 8 μg 12 hrs, larvae L3    12 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    38 cold shock, 4-day adult    18 heat shock, 4-day adult    30 Cadmium 50 mM 6 hrs, larvae L3    10 Cadmium 50 mM 12 hrs, larvae L3    14 Cadmium 50 mM 48 hrs, 4-day adult    31 Cadmium 100 mM 48 hrs, 4-day adult    70 Copper 0.5 mM 12 hrs, larvae L3    16 Copper 15 mM 48 hrs, 4-day adult    43 Zinc 5 mM 12 hrs, larvae L3    11 Zinc 4.5 mM 48 hrs, 4-day adult    20 Ethanol 2.5% 3 hrs, larvae L3    68 Ethanol 5% 3 hrs, larvae L3    20 Ethanol 10% 3 hrs, larvae L3    12 Caffeine 1.5 mg/ml 4 hrs, larvae L3    19 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    69 Caffeine 25 mg/ml 48 hrs, 4-day adult    34 Paraquat 5 mM 48 hrs, 4-day adult    51 Paraquat 10 mM 48 hrs, 4-day adult    47 Rotenone 2 μg 12 hrs, larvae L3    12 Rotenone 8 μg 12 hrs, larvae L3    12 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    38 cold shock, 4-day adult    18 heat shock, 4-day adult    30 Cadmium 50 mM 6 hrs, larvae L3    10 Cadmium 50 mM 12 hrs, larvae L3    14 Cadmium 50 mM 48 hrs, 4-day adult    31 Cadmium 100 mM 48 hrs, 4-day adult    70 Copper 0.5 mM 12 hrs, larvae L3    16 Copper 15 mM 48 hrs, 4-day adult    43 Zinc 5 mM 12 hrs, larvae L3    11 Zinc 4.5 mM 48 hrs, 4-day adult    20 Ethanol 2.5% 3 hrs, larvae L3    68 Ethanol 5% 3 hrs, larvae L3    20 Ethanol 10% 3 hrs, larvae L3    12 Caffeine 1.5 mg/ml 4 hrs, larvae L3    19 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    69 Caffeine 25 mg/ml 48 hrs, 4-day adult    34 Paraquat 5 mM 48 hrs, 4-day adult    51 Paraquat 10 mM 48 hrs, 4-day adult    47 Rotenone 2 μg 12 hrs, larvae L3    12 Rotenone 8 μg 12 hrs, larvae L3    12 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_13 mE1_20_mRNA_expression_cluster_03
External Data & Images
Linkouts	BDGP expression data • LD24527 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0037555 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG9638-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal | pharate adult stage Ada2bd272 Ada2bd842 lethal | pharate adult stage (with Df(3R)Ada2bd52) Ada2bd272 Ada2bd842 lethal | pupal stage | recessive Ada2b1 Ada2b2 lethal | pupal stage P5 Ada2bd272 Ada2bd842 lethal | pupal stage P5 (with Df(3R)Ada2bd52) Ada2bd272 Ada2bd842 partially lethal - majority die Ada2bHD-5 partially lethal - majority die | pupal stage, with Scer\GAL4pnr-MD237 Ada2bGD14276 Sterility Allele female sterile | germline clone | recessive Ada2b1 Ada2b2 Other Phenotypes Allele neuroanatomy defective Ada2b1 visible, with Scer\GAL4pnr-MD237 Ada2bGD14276 Phenotype manifest in Allele axon & photoreceptor cell R2 Ada2b1 axon & photoreceptor cell R3 Ada2b1 axon & photoreceptor cell R4 Ada2b1 axon & photoreceptor cell R5 Ada2b1 glial cell Ada2b1 trichogen cell, with Scer\GAL4pnr-MD237 Ada2bGD14276 wing disc | conditional Ada2bunspecified
Classical Alleles ( 9 )
For All Classical Alleles Show
Allele of Ada2b Class Mutagen Stocks Known lesion Ada2bG3857 P-element activity 1 -- Ada2bMI02565 1 -- Ada2b1 P-element activity 0 Yes Ada2b2 P-element activity 0 Yes Ada2bd272 Delta2-3 0 Yes Ada2bd842 Delta2-3 0 Yes Ada2bDG09704 0 -- Ada2bHD-5 0 -- Ada2bunspecified 0 --
Alleles Carried on Transgenic Constructs ( 11 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Ada2b Class Mutagen Stocks Known lesion Ada2bGD14276 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Ada2bGL00243 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Ada2bJF01305 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Ada2b+t6.1 in vitro construct - genomic fragment 0 Yes Ada2b+tPa in vitro construct - genomic fragment 0 Yes Ada2b1.Scer\UAS in vitro construct - regulatory fusion 0 Yes Ada2b2.Scer\UAS in vitro construct - regulatory fusion 0 Yes Ada2bNIG.9638R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes Ada2bScer\UAS.cVa in vitro construct - regulatory fusion 0 Yes Ada2bScer\UAS.P\T.T:Avic\GFP-EGFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes Ada2bScer\UAS.T:Zzzz\FLAG,T:Ivir\HA1 in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3R)Ada2bd52 (Pankotai et al., 2005) Df(3R)dsx5 (Qi et al., 2004)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct M{UAS-Ada2b.V} NA P{GD14276} NA P{NIG.9638R} NA P{TRiP.GL00243} NA P{TRiP.JF01305} NA P{UAS-Ada2b.1} NA P{UAS-Ada2b.2} NA P{UAS-Ada2b.HAFL2} NA P{UASp-Ada2b.EGFP} NA characterization construct M{UAS-Ada2a::Ada2b} NA M{UAS-Ada2bL::Ada2a} NA M{UAS-Ada2bM::Ada2a} NA M{UAS-Ada2bS::Ada2a} NA P{Ada2b.g} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EP}Ada2bG3857 NA P{EP}EP3412 NA miscellaneous insertions Mi{MIC}Ada2bMI02565 NA P{wHy}Ada2bDG09704 NA
Gene Ontology: Function, Process & Cellular Component ( 14 unique terms )
Terms Based on Experimental Evidence ( 10 terms )
Molecular Function
CV term Evidence References
protein binding inferred from physical interaction with UniProtKB:O76216 (assigned by UniProtKB) (Muratoglu et al., 2003) inferred from physical interaction with UniProtKB:Q9VWZ1 (assigned by UniProtKB) (Muratoglu et al., 2003)
Biological Process
CV term Evidence References
axon target recognition inferred from mutant phenotype (Weake et al., 2008) chromatin remodeling inferred from direct assay (assigned by UniProtKB) (Muratoglu et al., 2003) histone H3 acetylation inferred from mutant phenotype (Pankotai et al., 2005) positive regulation of histone acetylation inferred from mutant phenotype (Qi et al., 2004) regulation of transcription, DNA-dependent inferred from direct assay (assigned by UniProtKB) (Kusch et al., 2003) wing disc pattern formation inferred from genetic interaction with mam (Gause et al., 2006)
Cellular Component
CV term Evidence References
nucleus inferred from direct assay (Weake et al., 2011, Guelman et al., 2006) inferred from direct assay (assigned by UniProtKB) (Muratoglu et al., 2003) polytene chromosome inferred from direct assay (Muratoglu et al., 2003, Kusch et al., 2003, Nagy et al., 2010) SAGA complex inferred from direct assay (Weake et al., 2011, Guelman et al., 2006) inferred from physical interaction with Nipped-A AND inferred from physical interaction with Spt3 (Kusch et al., 2003)
Terms Based on Predictions or Assertions ( 5 terms )
Molecular Function
CV term Evidence References
chromatin binding inferred from electronic annotation with InterPro:IPR001005 (FlyBase Curators et al., 2004-) DNA binding inferred from electronic annotation with InterPro:IPR001005, InterPro:IPR012287 (FlyBase Curators et al., 2004-) histone acetyltransferase activity non-traceable author statement (Kusch, 2002.8.16) zinc ion binding inferred from electronic annotation with InterPro:IPR000433 (FlyBase Curators et al., 2004-)
Biological Process ( 0 terms)
Cellular Component
CV term Evidence References
SAGA complex non-traceable author statement (Kusch, 2002.8.16)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
Ada2b - Arpc3A anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Ada2b - CG9797 anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based (Mintseris et al., 2009.11.23, Guruharsha et al., 2011) Ada2b - HIP-R anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based (Mintseris et al., 2009.11.23, Guruharsha et al., 2011)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Ada2b allele Gene References Ada2b2 p53 (Qi et al., 2004)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 66149 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0037555 DroID - A comprehensive database of gene and protein interactions. • FBgn0037555 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 40966
Orthologs
OrthoDB Orthologs (38) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6CVGSJ Dipteran inclusive ortholog search EOG68D13P Insect inclusive ortholog search EOG6X96CQ Arthropod inclusive ortholog search EOG608KQJ Metazoa inclusive ortholog search EOG6WX4C6
Orthologs in Drosophila Species (EOG6CVGSJ)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\Ada2b     Drosophila simulans   Dsim\GD20886 Y   Drosophila sechellia   Dsec\GM26364 Y   Drosophila erecta   Dere\GG17470 Y   Drosophila yakuba   Dyak\GE24869 Y   Drosophila ananassae   Dana\GF16168 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA21933 Y   Drosophila persimilis   Dper\GL23274 Y   Drosophila willistoni   Dwil\GK14452 Y   Drosophila virilis   Dvir\GJ23060 Y   Drosophila mojavensis   Dmoj\GI24281 Y   Drosophila grimshawi   Dgri\GH19246 Y
Orthologs in non-Drosophila Dipterans (EOG68D13P)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL002137   Anopheles gambiae Malaria mosquito  Agam\AGAP003109   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ007393
Orthologs in non-Dipteran Insects (EOG6X96CQ)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB52323   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG011135   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH10233   Atta cephalotes Leafcutter ant  Acep\ACEP20806   Camponotus floridanus Florida carpenter ant  Cflo\CFLO16250   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL15812   Linepithema humile Argentine ant  Lhum\LH23419   Pogonomyrmex barbatus Red harvester ant  Pbar\PB17250   Solenopsis invicta Red fire ant  Sinv\SINV12506   Acyrthosiphon pisum Pea aphid  Apim\ACYPI009268   Bombyx mori Silkmoth  Bmor\BGIBMGA004964   Pediculus humanus Human body louse  Phum\PHUM333960   Tribolium castaneum Red flour beetle  Tcas\TC009145
Orthologs in non-Insect Arthropods (EOG608KQJ)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\JGI_V11_227604   Ixodes scapularis Deer tick  Isca\ISCW008979
Orthologs in non-Arthropod Metazoa (EOG6WX4C6)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\ada-2   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_024722gn   Danio rerio Zebrafish  Drer\tada2b   Xenopus tropicalis Western clawed frog  Xtro\tada2b   Gallus gallus Domestic chicken  Ggal\TADA2B   Mus musculus House mouse  Mmus\Tada2b   Rattus norvegicus Norway rat  Rnor\Tada2b   Homo sapiens Human  Hsap\TADA2B
Human Orthologs (1)
Gene OMIM HGNC Hsap\TADA2B
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD20886 Drosophila sechellia Dsec\GM26364 Drosophila erecta Dere\GG17470 Drosophila yakuba Dyak\GE24869 Drosophila ananassae Dana\GF16168 Drosophila pseudoobscura pseudoobscura Dpse\GA21933 Drosophila persimilis Dper\GL23274 Drosophila willistoni Dwil\GK14452 Drosophila virilis Dvir\GJ23060 Drosophila mojavensis Dmoj\GI24281 Drosophila grimshawi Dgri\GH19246
Stocks & Reagents
Stocks Listed in FlyBase ( 5 )
Bloomington	31778 w1118; P{EP}Ada2bG3857 31347 y1 v1; P{TRiP.JF01305}attP2 35334 y1 sc* v1; P{TRiP.GL00243}attP2 35869 y1 w*; Mi{MIC}Ada2bMI02565/TM3, Sb1 Ser1
VDRC	v24076 w1118; P{GD14276}v24076
Genomic Clones ( 1 )
	BACR45A07 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 48 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD24527
Other clones	DPiM_LD24527
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT08103 AT08115 AT21524 GM04293 LD04031 LD04096 LD08627 LD10552 LD12921 LD14359 LD25858 LD28367 LD29713 LD37014 LD37863 LD46810 RE11394 RE12656 RE17111 RE19534 RE22581 RE23370 RE29242 RE36995 RE42657 RE47623 RH37408
Other clones	Dmel_dig_006956_0610_0532 Dmel_dig_011445_0697_1680 Dmel_dig_017683_0584_2677 Dmel_dig_020782_0599_0692 Dmel_neb_012363_0641_1234 Dmel_neb_013317_0695_2704 Dmel_neb_014357_0842_0542 Dmel_neb_015690_0653_1443 EK056422 EK116804 EK139419 EK174845 EK185037 EK228646 EK249405 EK257445 EK259562 EK295950 EP08749
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0037555 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 40966
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments
Other Comments
	wda, Spt3 and Ada2b associate in a complex. (Guelman et al., 2006) dsRNA has been made from templates generated with primers directed against this gene. (Marr et al., 2006) Mutants show a reduction in acetylation of His3 protein. Mutants show excessive p53-dependent apoptosis in response to gamma radiation. (Qi et al., 2004) Ada2b is part of a SAGA-type complex. (Dai and Mannervik, 2003) Ada2b mutant animals die as pupae without any gross morphological abnormalities. However, Ada2b is maternally contributed to the early embryo, which may mask an earlier phenotype. (Dai and Mannervik, 2003) Loss of Ada2b function results in segmentation defects as well as massive apoptosis at the onset of early embryonic differentiation. (Kusch et al., 2003) Mutants show pupal lethality. (Pankotai et al., 2003)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_141516 NM_001031980 NM_001275438 RefSeq (Proteins) • NP_649773 NP_001027151 NP_001262367 DDBJ / EMBL / GenBank • AA820681 AAF54199 AAF54199.1 AAL13775 AAN52141 AAZ52519 AGB95749 AI455492 AY058546 AY142213 Entrez Gene - A searchable database of RefSeq genes. • 40966 UniProtKB/Swiss-Prot • Q8I8V0
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Zinc finger, ZZ-type (IPR000433) SANT/Myb domain (IPR001005) Homeodomain-like (IPR009057) Transcriptional adaptor 2 (IPR016827) SANT domain (IPR017884) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • LD24527
Linkouts
	BioGRID - A database of protein and genetic interactions • 66149 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0037555 DroID - A comprehensive database of gene and protein interactions. • FBgn0037555 DRSC - Results from RNAi screens. • FBgn0037555 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0037555 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG9638-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0037555 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 40966 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 40966 modMine - Data generated by the modENCODE project. • FBgn0037555
Synonyms & Secondary IDs ( 13 )
Reported As
Symbol Synonym	ada2b (Pankotai et al., 2003, Weake et al., 2008, Smibert et al., 2012) ADA2b (Pankotai et al., 2005, Nagy et al., 2010, Kurshakova et al., 2009) Ada2b (Guelman et al., 2006, Marr et al., 2006, Blanco et al., 2010, Weake et al., 2011, Gan et al., 2010, Pankotai et al., 2005, Gause et al., 2006, Ciurciu et al., 2009, Nagy et al., 2010, Toku et al., 2011, Hsu et al., 2008, Carré et al., 2008, Tombácz et al., 2009, Curtis et al., 2007, Japanese National Institute of Genetics, 2012.5.21, Spedale et al., 2012, Bodai et al., 2012) Ada2B (Weake et al., 2009) Ada2S   BcDNA:LD24527   CG9638 (Giot et al., 2003, Gandhi et al., 2007, Ni et al., 2008, Ni et al., 2011.7.19) dAda2b (Qi et al., 2004, Kusch et al., 2003, Muratoglu et al., 2003, Guelman et al., 2006, Grau et al., 2008, Ciurciu et al., 2009, Zsindely et al., 2009, Vamos and Boros, 2012) dAda2B (Guelman et al., 2006) dADA2b (Kurshakova et al., 2007, Lebedeva et al., 2004, Nagy et al., 2010) dAda2S (Kusch et al., 2003)
Name Synonym	Ada2b   Transcriptional adapter 2S   transcriptional Adaptor 2b
Secondary FlyBase IDs
References ( 57 )
Generate a list of	All references relating to this gene ( 57 )
List References by type	Research paper  ( 29 ) Supplementary material  ( 7 ) Review  ( 1 ) Personal communication to FlyBase  ( 8 ) Abstract  ( 4 ) FlyBase analysis  ( 2 ) Stock list  ( 1 ) DNA/RNA sequence record  ( 1 ) Website  ( 1 ) Curated genome annotation  ( 2 )
Recent research papers ( 4 )
	Bodai et al., 2012, PLoS ONE 7(7): e40565 Ecdysone Induced Gene Expression Is Associated with Acetylation of Histone H3 Lysine 23 in Drosophila melanogaster. [FBrf0218867] Vamos and Boros, 2012, FEBS Lett. 586(19): 3279--3286 The C-terminal domains of ADA2 proteins determine selective incorporation into GCN5-containing complexes that target histone H3 or H4 for acetylation. [FBrf0219600] Toku et al., 2011, Comput. Biol. Chem. 35(5): 282--292 Reconstruction and crosstalk of protein-protein interaction networks of Wnt and Hedgehog signaling in Drosophila melanogaster. [FBrf0216393] Weake et al., 2011, Genes Dev. 25(14): 1499--1509 Post-transcription initiation function of the ubiquitous SAGA complex in tissue-specific gene activation. [FBrf0214372] Show all research papers ...
Recent reviews ( 1 )
	Spedale et al., 2012, Genes Dev. 26(6): 527--541 ATAC-king the complexity of SAGA during evolution. [FBrf0219841] Show all reviews ...