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Gene Dmel\Gfr

General Information
Symbol	Dmel\Gfr	Species	D. melanogaster
Name	Gfr	Annotation symbol	CG9620
Feature type	protein_coding_gene	FlyBase ID	FBgn0037567
Gene Model Status	Current	Stock availability	2 publicly available
Genomic Location
Chromosome (arm)	3R	Recombination map
Cytogenetic map	84F10-84F10	Sequence location	3R:4,128,408..4,129,733 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Gfr is referred to in FlyBase by the symbol Dmel\Gfr (CG9620, FBgn0037567). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: GDP-fucose transmembrane transporter activity. There is experimental evidence that it is involved in the biological process: GDP-fucose transport. 8 alleles are reported. The phenotypes of these alleles are annotated with: wing vein L3; wing vein L4. It has one annotated transcript and one annotated polypeptide. Protein features are: Domain of unknown function DUF250. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of low expression. Peak expression observed within 00-18 hour embryonic stages, at stages throughout the larval period, at stages throughout the pupal period, in adult female stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval/adult midgut, larval Malpighian tubules, larval fat body, larval/adult salivary gland, larval trachea, adult male accessory gland. Comments on Affy2 ProbeSet: ProbeSet 1628755_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of Gfr. Gene sequence location is 3R:4128408..4129733.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2011_10
FB2012_01	Sequence features HFA16520 BKN21218
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 84F10-84F10   Limits computationally determined from genome sequence between P{PZ}Mcm2rL074 and P{EP}EP833
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Gfr for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Gfr-RA FBtr0081863  NM_141525   1213   337
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Gfr-PA   FBpp0081352   38.1   337   9.24     NP_649782   AAF54215
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Domain of unknown function DUF250 (IPR004853)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014297 AAF54215   BI243034   BI366724   BT003501 AAO39505   CO340169   EC247107   EC254595   EV585252   GH750109   GH753313   GH754381   GH754816   GH759894   GH771714   GH772902   GH780086   GH791127   GH793065   GH798579   GH804222   GH806627   GH815507   GH816947   GH817070   GH820127   GH821363   GH827490   GH834145   GH849022   GH854232   GH858359   GH858875   GH859091   GH861810   GH870749   GH877764   GH893119   GH906476   GH907581   GH910564   GH919544   GH920939   GH930978   GH931085
UniProtKB/Swiss-Prot	Q9VHT4
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0037567    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0037567 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of low expression. Peak expression observed within 00-18 hour embryonic stages, at stages throughout the larval period, at stages throughout the pupal period, in adult female stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0037567 expression level Developmental Stage   Expression Level embryo 00-02hr    802 embryo 02-04hr    819 embryo 04-06hr    797 embryo 06-08hr    531 embryo 08-10hr    521 embryo 10-12hr    771 embryo 12-14hr    626 embryo 14-16hr    495 embryo 16-18hr    321 embryo 18-20hr    224 embryo 20-22hr    234 embryo 22-24hr    211 larva L1    531 larva L2    603 larva L3 12hr old    570 larva L3 puffstage 1-2    668 larva L3 puffstage 3-6    588 larva L3 puffstage 7-9    712 white prepupae new    574 white prepupae 12hr    442 white prepupae 24hr    464 pupae 2d postWPP    410 pupae 3d postWPP    320 pupae 4d postWPP    258 adult male 01day    344 adult male 05day    319 adult male 30day    303 adult female 01day    455 adult female 05day    606 adult female 30day    616 Expression Level Scale  None   Extremely low   Very low   Low   Moderate  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (802) embryo 02-04hr  (819) embryo 04-06hr  (797) embryo 06-08hr  (531) embryo 08-10hr  (521) embryo 10-12hr  (771) embryo 12-14hr  (626) embryo 14-16hr  (495) embryo 16-18hr  (321) embryo 18-20hr  (224) embryo 20-22hr  (234) embryo 22-24hr  (211) larva L1  (531) larva L2  (603) larva L3 12hr old  (570) larva L3 puffstage 1-2  (668) larva L3 puffstage 3-6  (588) larva L3 puffstage 7-9  (712) white prepupae new  (574) white prepupae 12hr  (442) white prepupae 24hr  (464) pupae 2d postWPP  (410) pupae 3d postWPP  (320) pupae 4d postWPP  (258) adult male 01day  (344) adult male 05day  (319) adult male 30day  (303) adult female 01day  (455) adult female 05day  (606) adult female 30day  (616) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    802 embryo 02-04hr    819 embryo 04-06hr    797 embryo 06-08hr    531 embryo 08-10hr    521 embryo 10-12hr    771 embryo 12-14hr    626 embryo 14-16hr    495 embryo 16-18hr    321 embryo 18-20hr    224 embryo 20-22hr    234 embryo 22-24hr    211 larva L1    531 larva L2    603 larva L3 12hr old    570 larva L3 puffstage 1-2    668 larva L3 puffstage 3-6    588 larva L3 puffstage 7-9    712 white prepupae new    574 white prepupae 12hr    442 white prepupae 24hr    464 pupae 2d postWPP    410 pupae 3d postWPP    320 pupae 4d postWPP    258 adult male 01day    344 adult male 05day    319 adult male 30day    303 adult female 01day    455 adult female 05day    606 adult female 30day    616 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    802 embryo 02-04hr    819 embryo 04-06hr    797 embryo 06-08hr    531 embryo 08-10hr    521 embryo 10-12hr    771 embryo 12-14hr    626 embryo 14-16hr    495 embryo 16-18hr    321 embryo 18-20hr    224 embryo 20-22hr    234 embryo 22-24hr    211 larva L1    531 larva L2    603 larva L3 12hr old    570 larva L3 puffstage 1-2    668 larva L3 puffstage 3-6    588 larva L3 puffstage 7-9    712 white prepupae new    574 white prepupae 12hr    442 white prepupae 24hr    464 pupae 2d postWPP    410 pupae 3d postWPP    320 pupae 4d postWPP    258 adult male 01day    344 adult male 05day    319 adult male 30day    303 adult female 01day    455 adult female 05day    606 adult female 30day    616 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    802 embryo 02-04hr    819 embryo 04-06hr    797 embryo 06-08hr    531 embryo 08-10hr    521 embryo 10-12hr    771 embryo 12-14hr    626 embryo 14-16hr    495 embryo 16-18hr    321 embryo 18-20hr    224 embryo 20-22hr    234 embryo 22-24hr    211 larva L1    531 larva L2    603 larva L3 12hr old    570 larva L3 puffstage 1-2    668 larva L3 puffstage 3-6    588 larva L3 puffstage 7-9    712 white prepupae new    574 white prepupae 12hr    442 white prepupae 24hr    464 pupae 2d postWPP    410 pupae 3d postWPP    320 pupae 4d postWPP    258 adult male 01day    344 adult male 05day    319 adult male 30day    303 adult female 01day    455 adult female 05day    606 adult female 30day    616 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0037567 expression level Developmental Stage   Expression Level embryo 00-02hr    802 embryo 02-04hr    819 embryo 04-06hr    797 embryo 06-08hr    531 embryo 08-10hr    521 embryo 10-12hr    771 embryo 12-14hr    626 embryo 14-16hr    495 embryo 16-18hr    321 embryo 18-20hr    224 embryo 20-22hr    234 embryo 22-24hr    211 larva L1    531 larva L2    603 larva L3 12hr old    570 larva L3 puffstage 1-2    668 larva L3 puffstage 3-6    588 larva L3 puffstage 7-9    712 white prepupae new    574 white prepupae 12hr    442 white prepupae 24hr    464 pupae 2d postWPP    410 pupae 3d postWPP    320 pupae 4d postWPP    258 adult male 01day    344 adult male 05day    319 adult male 30day    303 adult female 01day    455 adult female 05day    606 adult female 30day    616 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (802) embryo 02-04hr  (819) embryo 04-06hr  (797) embryo 06-08hr  (531) embryo 08-10hr  (521) embryo 10-12hr  (771) embryo 12-14hr  (626) embryo 14-16hr  (495) embryo 16-18hr  (321) embryo 18-20hr  (224) embryo 20-22hr  (234) embryo 22-24hr  (211) larva L1  (531) larva L2  (603) larva L3 12hr old  (570) larva L3 puffstage 1-2  (668) larva L3 puffstage 3-6  (588) larva L3 puffstage 7-9  (712) white prepupae new  (574) white prepupae 12hr  (442) white prepupae 24hr  (464) pupae 2d postWPP  (410) pupae 3d postWPP  (320) pupae 4d postWPP  (258) adult male 01day  (344) adult male 05day  (319) adult male 30day  (303) adult female 01day  (455) adult female 05day  (606) adult female 30day  (616) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    802 embryo 02-04hr    819 embryo 04-06hr    797 embryo 06-08hr    531 embryo 08-10hr    521 embryo 10-12hr    771 embryo 12-14hr    626 embryo 14-16hr    495 embryo 16-18hr    321 embryo 18-20hr    224 embryo 20-22hr    234 embryo 22-24hr    211 larva L1    531 larva L2    603 larva L3 12hr old    570 larva L3 puffstage 1-2    668 larva L3 puffstage 3-6    588 larva L3 puffstage 7-9    712 white prepupae new    574 white prepupae 12hr    442 white prepupae 24hr    464 pupae 2d postWPP    410 pupae 3d postWPP    320 pupae 4d postWPP    258 adult male 01day    344 adult male 05day    319 adult male 30day    303 adult female 01day    455 adult female 05day    606 adult female 30day    616 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    802 embryo 02-04hr    819 embryo 04-06hr    797 embryo 06-08hr    531 embryo 08-10hr    521 embryo 10-12hr    771 embryo 12-14hr    626 embryo 14-16hr    495 embryo 16-18hr    321 embryo 18-20hr    224 embryo 20-22hr    234 embryo 22-24hr    211 larva L1    531 larva L2    603 larva L3 12hr old    570 larva L3 puffstage 1-2    668 larva L3 puffstage 3-6    588 larva L3 puffstage 7-9    712 white prepupae new    574 white prepupae 12hr    442 white prepupae 24hr    464 pupae 2d postWPP    410 pupae 3d postWPP    320 pupae 4d postWPP    258 adult male 01day    344 adult male 05day    319 adult male 30day    303 adult female 01day    455 adult female 05day    606 adult female 30day    616 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    802 embryo 02-04hr    819 embryo 04-06hr    797 embryo 06-08hr    531 embryo 08-10hr    521 embryo 10-12hr    771 embryo 12-14hr    626 embryo 14-16hr    495 embryo 16-18hr    321 embryo 18-20hr    224 embryo 20-22hr    234 embryo 22-24hr    211 larva L1    531 larva L2    603 larva L3 12hr old    570 larva L3 puffstage 1-2    668 larva L3 puffstage 3-6    588 larva L3 puffstage 7-9    712 white prepupae new    574 white prepupae 12hr    442 white prepupae 24hr    464 pupae 2d postWPP    410 pupae 3d postWPP    320 pupae 4d postWPP    258 adult male 01day    344 adult male 05day    319 adult male 30day    303 adult female 01day    455 adult female 05day    606 adult female 30day    616 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0037567    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0037567 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval/adult midgut, larval Malpighian tubules, larval fat body, larval/adult salivary gland, larval trachea, adult male accessory gland. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0037567 expression level Tissue   Expression Level Larval Central Nervous System    77.55 Larval Midgut    116.8 Larval Hindgut    87.1 Larval Malpighian Tubules    138.2 Larval Fat Body    114.4 Larval Salivary Gland    383.9 Larval Trachea    100.45 Larval Carcass    70.975 Adult Head    42.2 Adult Eye    42.325 Adult Brain    39.7 Adult Thoracic-Abdominal Ganglion    52.3 Adult Crop    51.2 Adult Midgut    136.2 Adult Hindgut    60.2 Adult Malpighian Tubules    75.9 Adult Fat Body    74.4 Adult Salivary Gland    118.8 Adult Heart    57.35 Adult VirginFemale Spermatheca    69.7 Adult InseminatedFemale Spermatheca    67.6 Adult Ovary    60.2 Adult Testis    11.8 Adult Male Accessory Gland    250.6 Adult Carcass    58.3 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    77.55 Larval Midgut    116.8 Larval Hindgut    87.1 Larval Malpighian Tubules    138.2 Larval Fat Body    114.4 Larval Salivary Gland    383.9 Larval Trachea    100.45 Larval Carcass    70.975 Adult Head    42.2 Adult Eye    42.325 Adult Brain    39.7 Adult Thoracic-Abdominal Ganglion    52.3 Adult Crop    51.2 Adult Midgut    136.2 Adult Hindgut    60.2 Adult Malpighian Tubules    75.9 Adult Fat Body    74.4 Adult Salivary Gland    118.8 Adult Heart    57.35 Adult VirginFemale Spermatheca    69.7 Adult InseminatedFemale Spermatheca    67.6 Adult Ovary    60.2 Adult Testis    11.8 Adult Male Accessory Gland    250.6 Adult Carcass    58.3 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    77.55 Larval Midgut    116.8 Larval Hindgut    87.1 Larval Malpighian Tubules    138.2 Larval Fat Body    114.4 Larval Salivary Gland    383.9 Larval Trachea    100.45 Larval Carcass    70.975 Adult Head    42.2 Adult Eye    42.325 Adult Brain    39.7 Adult Thoracic-Abdominal Ganglion    52.3 Adult Crop    51.2 Adult Midgut    136.2 Adult Hindgut    60.2 Adult Malpighian Tubules    75.9 Adult Fat Body    74.4 Adult Salivary Gland    118.8 Adult Heart    57.35 Adult VirginFemale Spermatheca    69.7 Adult InseminatedFemale Spermatheca    67.6 Adult Ovary    60.2 Adult Testis    11.8 Adult Male Accessory Gland    250.6 Adult Carcass    58.3 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    77.55 Larval Midgut    116.8 Larval Hindgut    87.1 Larval Malpighian Tubules    138.2 Larval Fat Body    114.4 Larval Salivary Gland    383.9 Larval Trachea    100.45 Larval Carcass    70.975 Adult Head    42.2 Adult Eye    42.325 Adult Brain    39.7 Adult Thoracic-Abdominal Ganglion    52.3 Adult Crop    51.2 Adult Midgut    136.2 Adult Hindgut    60.2 Adult Malpighian Tubules    75.9 Adult Fat Body    74.4 Adult Salivary Gland    118.8 Adult Heart    57.35 Adult VirginFemale Spermatheca    69.7 Adult InseminatedFemale Spermatheca    67.6 Adult Ovary    60.2 Adult Testis    11.8 Adult Male Accessory Gland    250.6 Adult Carcass    58.3 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0037567 expression level Tissue   Expression Level Larval Central Nervous System    77.55 Larval Midgut    116.8 Larval Hindgut    87.1 Larval Malpighian Tubules    138.2 Larval Fat Body    114.4 Larval Salivary Gland    383.9 Larval Trachea    100.45 Larval Carcass    70.975 Adult Head    42.2 Adult Eye    42.325 Adult Brain    39.7 Adult Thoracic-Abdominal Ganglion    52.3 Adult Crop    51.2 Adult Midgut    136.2 Adult Hindgut    60.2 Adult Malpighian Tubules    75.9 Adult Fat Body    74.4 Adult Salivary Gland    118.8 Adult Heart    57.35 Adult VirginFemale Spermatheca    69.7 Adult InseminatedFemale Spermatheca    67.6 Adult Ovary    60.2 Adult Testis    11.8 Adult Male Accessory Gland    250.6 Adult Carcass    58.3 Expression Level Scale  None   Low   Moderate   High  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    77.55 Larval Midgut    116.8 Larval Hindgut    87.1 Larval Malpighian Tubules    138.2 Larval Fat Body    114.4 Larval Salivary Gland    383.9 Larval Trachea    100.45 Larval Carcass    70.975 Adult Head    42.2 Adult Eye    42.325 Adult Brain    39.7 Adult Thoracic-Abdominal Ganglion    52.3 Adult Crop    51.2 Adult Midgut    136.2 Adult Hindgut    60.2 Adult Malpighian Tubules    75.9 Adult Fat Body    74.4 Adult Salivary Gland    118.8 Adult Heart    57.35 Adult VirginFemale Spermatheca    69.7 Adult InseminatedFemale Spermatheca    67.6 Adult Ovary    60.2 Adult Testis    11.8 Adult Male Accessory Gland    250.6 Adult Carcass    58.3 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    77.55 Larval Midgut    116.8 Larval Hindgut    87.1 Larval Malpighian Tubules    138.2 Larval Fat Body    114.4 Larval Salivary Gland    383.9 Larval Trachea    100.45 Larval Carcass    70.975 Adult Head    42.2 Adult Eye    42.325 Adult Brain    39.7 Adult Thoracic-Abdominal Ganglion    52.3 Adult Crop    51.2 Adult Midgut    136.2 Adult Hindgut    60.2 Adult Malpighian Tubules    75.9 Adult Fat Body    74.4 Adult Salivary Gland    118.8 Adult Heart    57.35 Adult VirginFemale Spermatheca    69.7 Adult InseminatedFemale Spermatheca    67.6 Adult Ovary    60.2 Adult Testis    11.8 Adult Male Accessory Gland    250.6 Adult Carcass    58.3 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    77.55 Larval Midgut    116.8 Larval Hindgut    87.1 Larval Malpighian Tubules    138.2 Larval Fat Body    114.4 Larval Salivary Gland    383.9 Larval Trachea    100.45 Larval Carcass    70.975 Adult Head    42.2 Adult Eye    42.325 Adult Brain    39.7 Adult Thoracic-Abdominal Ganglion    52.3 Adult Crop    51.2 Adult Midgut    136.2 Adult Hindgut    60.2 Adult Malpighian Tubules    75.9 Adult Fat Body    74.4 Adult Salivary Gland    118.8 Adult Heart    57.35 Adult VirginFemale Spermatheca    69.7 Adult InseminatedFemale Spermatheca    67.6 Adult Ovary    60.2 Adult Testis    11.8 Adult Male Accessory Gland    250.6 Adult Carcass    58.3 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    42.2   NA  Eye    42.325   NA  Brain    39.7   77.55  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    52.3   NA  Crop    51.2   116.8  Midgut    136.2   87.1  Hindgut    60.2   138.2  Malpighian Tubules    75.9   114.4  Fat Body    74.4   383.9  Salivary Gland    118.8   NA  Heart    57.35   100.45  Trachea    NA   NA  VirginFemale Spermatheca    69.7   NA  InseminatedFemale Spermatheca    67.6   NA  Ovary    60.2   NA  Testis    11.8   NA  Male Accessory Gland    250.6   70.975  Carcass    58.3 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_03
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0037567 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG9620-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable, with Scer\GAL4pnr-MD237 GfrGD2857 Phenotype manifest in Allele wing | heat sensitive Gfr1 Gfr2 wing | heat sensitive (with Df(3R)Exel6147) Gfr1 Gfr2 wing | heat sensitive (with Gfr1) Gfr2 wing | heat sensitive (with Gfr2) Gfr1 wing vein L3 Gfr2 wing vein L3 | heat sensitive Gfr1 wing vein L4 Gfr2 wing vein L4 | heat sensitive Gfr1
Classical Alleles ( 3 )
For All Classical Alleles Show
Allele of Gfr Class Mutagen Stocks Known lesion Gfr1 Delta2-3 0 Yes Gfr2 Delta2-3 0 Yes GfrEY01553 P-element activity 0 --
Alleles Carried on Transgenic Constructs ( 5 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Gfr Class Mutagen Stocks Known lesion GfrGD2857 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes GfrKK101122 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes GfrR125C.Scer\UAS in vitro construct - amino acid replacement in vitro construct - regulatory fusion 0 Yes GfrScer\UAS.cIa in vitro construct - regulatory fusion 0 Yes GfrScer\UAS.T:Ivir\HA1 in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3R)Exel6147 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD2857} NA P{KK101122} NA P{UAS-Gfr.I} NA P{UAS-Gfr.R125C} NA P{UAS-Gfr-HA.I} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EPgy2}EY01553 NA P{EPgy2}GfrEY01553 NA
Gene Ontology: Function, Process & Cellular Component ( 5 unique terms )
Terms Based on Experimental Evidence ( 3 terms )
Molecular Function
CV term Evidence References
GDP-fucose transmembrane transporter activity inferred from direct assay (Luehn et al., 2004)
Biological Process
CV term Evidence References
GDP-fucose transport inferred from direct assay (Luehn et al., 2004)
Cellular Component
CV term Evidence References
Golgi-associated vesicle inferred from direct assay (Luehn et al., 2004)
Terms Based on Predictions or Assertions ( 4 terms )
Molecular Function
CV term Evidence References
GDP-fucose transmembrane transporter activity non-traceable author statement (Swiss-Prot Project Members, 2002.3.1) traceable author statement (assigned by UniProtKB) (Roos et al., 2002)
Biological Process
CV term Evidence References
GDP-fucose transport non-traceable author statement (Swiss-Prot Project Members, 2002.3.1) traceable author statement (assigned by UniProtKB) (Roos et al., 2002) Golgi vesicle transport non-traceable author statement (Ishikawa et al., 2005)
Cellular Component
CV term Evidence References
Golgi apparatus non-traceable author statement (Ishikawa et al., 2005, Swiss-Prot Project Members, 2002.3.1)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Gfr allele Gene References
External Data
Linkouts	DroID - A comprehensive database of gene and protein interactions. • FBgn0037567
Orthologs
Genome-wide drosophilid orthologs	Dana\GF16675 Dere\GG17462 Dgri\GH18913 Dmoj\GI23412 Dper\GL24125 Dpse\GA21918 Dsec\GM26356 Dsim\GD20878 Dvir\GJ10619 Dwil\GK11707 Dyak\GE24861
Curated drosophilid orthologs	Dpse\GA21918
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL007481-PA Aedes aegypti (mosquito) AGAP002393-PA Anopheles gambiae (mosquito) XP_623632.1 Apis mellifera (honey bee) XP_001949938.1 Acyrthosiphon pisum (pea aphid) 118197 Branchiostoma floridae (lancelet) BGIBMGA000854-PA Bombyx mori (silk worm) ENSBTAP00000004155 Bos taurus (bovine) CN21118 Caenorhabditis brenneri (small nematode) CBP30043 Caenorhabditis briggsae (nematode) CE30910 Caenorhabditis elegans (worm) ENSCAFP00000013816 Canis familiaris (dog) Chro.40354 Cryptosporidium hominis (obligate parasite) ENSCINP00000007526 Ciona intestinalis (sea squirt) JA10132 Caenorhabditis japonica (nematode) CMT467C Cyanidioschyzon merolae (red alga) cgd4_3110 Cryptosporidium parvum (protozoan parasite) CPIJ009824 Culex pipens (mosquito) ENSCPOP00000001176 Cavia porcellus (guinea pig) 114747 Chlamidomonas reinhardtii (green alga) RP08767 Caenorhabditis remanei (nematode) ENSCSAVP00000012495 Ciona savignyi (sedentary tunicate) 180321 Capitella spl (polychaete worm) DDB0217856 Dictyostelium discoideum (amoeba) 321827 Daphnia pulex (daphnia) ENSDARP00000032069 Danio rerio (zebra fish) ENSECAP00000000593 Equus caballus (horse) ENSGACP00000022611 Gymnopilus aculeatus (mushroom) ENSGALP00000013733 Gallus gallus (chicken) 65661 Hypsipyla robusta (cedar shoot borer) ENSP00000313318 Homo sapiens (human) ISCW014762-PA Ixodes scapularis (deer tick) 130787 Lottia gigantea (owl limpet) 18313 Monocosta brevicollis (choanoflagellate) ENSMODP00000024804 Monodelphis domestica (gray opossum) ENSMMUP00000003302 Macaca mulatta (rhesus monkey) ENSMUSP00000063461 Mus musculus (house mouse) 205399 Nematostella vectensis (starlet anemone) XP_001605099.1 Nasonia vitripennis (wasp) ENSOANP00000008515 Ornithorynchus anatinus (platypus) ENSORLP00000001157 Oryzias latipes (japanese killifish) PHUM000151-PA Pediculus humanus (human body louse) PP09768 Pristionchus pacificus (nematode) ENSPPYP00000003823 Pongo pygmaeus (orangutan) ENSPTRP00000006138 Pan troglodytes (chimpanzee) PVX_002930 Plasmodium vivax (protozoal parasite) ENSRNOP00000010278 Rattus norvegicus (norway rat) SPAC22F8.04 Schizosaccharomyces pombe (fission yeast) XP_001175570.1 Strongylocentrotus purpuratus (purple sea urchin) 20354 Trichoplax adhaerens (metazoa) XP_967192.1 Tribolium castaneum (red flour beetle) Tc00.1047053511517.150 Trypanosoma cruzi (parasitic trypanosome) Tc00.1047053511737.70 Trypanosoma cruzi (parasitic trypanosome) ENSTNIP00000012479 Tetraodon nigroviridis (green spotted pufferfish) 38157 Thalassiosira pseudonana (marine diatom) ENSTRUP00000041409 Takifugu rubripes (pufferfish Takifugu) 96829.m00056 Trichomonas vaginalis (parasitic flagellated protozoan) ENSXETP00000002223 Xenopus tropicalis (frog) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV16373 LH20094 ISCW014762 FBgn0241959 FBgn0213718 FBgn0197898 FBgn0192338 FBgn0181209 JGI_V11_321827 FBgn0081903 FBgn0161715 FBgn0146138 FBgn0126380 FBgn0109687 FBgn0093696 CPIJ009824 BGIBMGA000854 ACYPI002072 GB13786 AGAP002393 AAEL007481 PB20988 PHUM283340 GLEAN_12326
Stocks & Reagents
Stocks Listed in FlyBase ( 2 )
VDRC	v105410 P{KK101122}VIE-260B v42623 w1118; P{GD2857}v42623
Genomic Clones ( 1 )
	BACR33N15 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 40 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	RE40567
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	RE52321
Other clones	Dmel_dig_006672_0709_1154 EP10136 RP003023416 RP003050173 RP003063155 RP003072452 RP003083325 RP003110410 RP003110481 RP003118765 RP003122065 RP003126708 RP003144582 RP003162972 RP003163723 RP003172743 RP003180200 RP003185545 RP003198222 RP003199218 RP003225004 RP003235463 RP003272656 RP003273073 RP003287418 RP003306607 RP003312749 RP003336257 RP003370293 RP003434703 RP003461094 RP003462249 RP003488654 RP003527422 RP003598477 RP003615732 RP003650372 RP003651633
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0037567 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 40981
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: Gfr CG9620 (Ishikawa, 2005.3.7)
Source for database merge of
Additional comments
Other Comments
	Gfr may transport GDP-fucose from the cytosol into the golgi. (Ishikawa et al., 2005) N signaling deteriorates in Gfr mutants. (Ishikawa et al., 2005)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_141525 RefSeq (Proteins) • NP_649782 DDBJ / EMBL / GenBank • AAF54215 AAO39505 BI243034 BT003501 Entrez Gene - A searchable database of RefSeq genes. • 40981 UniProtKB/Swiss-Prot • Q9VHT4
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Domain of unknown function DUF250 (IPR004853)
Linkouts
	DroID - A comprehensive database of gene and protein interactions. • FBgn0037567 DRSC - Results from RNAi screens. • FBgn0037567 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0037567 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG9620-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0037567 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 40981 InParanoid A subset of ortholog calls from InParanoid. • AAEL007481-PA Aedes aegypti (mosquito) AGAP002393-PA Anopheles gambiae (mosquito) XP_623632.1 Apis mellifera (honey bee) XP_001949938.1 Acyrthosiphon pisum (pea aphid) 118197 Branchiostoma floridae (lancelet) BGIBMGA000854-PA Bombyx mori (silk worm) ENSBTAP00000004155 Bos taurus (bovine) CN21118 Caenorhabditis brenneri (small nematode) CBP30043 Caenorhabditis briggsae (nematode) CE30910 Caenorhabditis elegans (worm) ENSCAFP00000013816 Canis familiaris (dog) Chro.40354 Cryptosporidium hominis (obligate parasite) ENSCINP00000007526 Ciona intestinalis (sea squirt) JA10132 Caenorhabditis japonica (nematode) CMT467C Cyanidioschyzon merolae (red alga) cgd4_3110 Cryptosporidium parvum (protozoan parasite) CPIJ009824 Culex pipens (mosquito) ENSCPOP00000001176 Cavia porcellus (guinea pig) 114747 Chlamidomonas reinhardtii (green alga) RP08767 Caenorhabditis remanei (nematode) ENSCSAVP00000012495 Ciona savignyi (sedentary tunicate) 180321 Capitella spl (polychaete worm) DDB0217856 Dictyostelium discoideum (amoeba) 321827 Daphnia pulex (daphnia) ENSDARP00000032069 Danio rerio (zebra fish) ENSECAP00000000593 Equus caballus (horse) ENSGACP00000022611 Gymnopilus aculeatus (mushroom) ENSGALP00000013733 Gallus gallus (chicken) 65661 Hypsipyla robusta (cedar shoot borer) ENSP00000313318 Homo sapiens (human) ISCW014762-PA Ixodes scapularis (deer tick) 130787 Lottia gigantea (owl limpet) 18313 Monocosta brevicollis (choanoflagellate) ENSMODP00000024804 Monodelphis domestica (gray opossum) ENSMMUP00000003302 Macaca mulatta (rhesus monkey) ENSMUSP00000063461 Mus musculus (house mouse) 205399 Nematostella vectensis (starlet anemone) XP_001605099.1 Nasonia vitripennis (wasp) ENSOANP00000008515 Ornithorynchus anatinus (platypus) ENSORLP00000001157 Oryzias latipes (japanese killifish) PHUM000151-PA Pediculus humanus (human body louse) PP09768 Pristionchus pacificus (nematode) ENSPPYP00000003823 Pongo pygmaeus (orangutan) ENSPTRP00000006138 Pan troglodytes (chimpanzee) PVX_002930 Plasmodium vivax (protozoal parasite) ENSRNOP00000010278 Rattus norvegicus (norway rat) SPAC22F8.04 Schizosaccharomyces pombe (fission yeast) XP_001175570.1 Strongylocentrotus purpuratus (purple sea urchin) 20354 Trichoplax adhaerens (metazoa) XP_967192.1 Tribolium castaneum (red flour beetle) Tc00.1047053511517.150 Trypanosoma cruzi (parasitic trypanosome) Tc00.1047053511737.70 Trypanosoma cruzi (parasitic trypanosome) ENSTNIP00000012479 Tetraodon nigroviridis (green spotted pufferfish) 38157 Thalassiosira pseudonana (marine diatom) ENSTRUP00000041409 Takifugu rubripes (pufferfish Takifugu) 96829.m00056 Trichomonas vaginalis (parasitic flagellated protozoan) ENSXETP00000002223 Xenopus tropicalis (frog) modMine - Data generated by the modENCODE project. • FBgn0037567 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV16373 LH20094 ISCW014762 FBgn0241959 FBgn0213718 FBgn0197898 FBgn0192338 FBgn0181209 JGI_V11_321827 FBgn0081903 FBgn0161715 FBgn0146138 FBgn0126380 FBgn0109687 FBgn0093696 CPIJ009824 BGIBMGA000854 ACYPI002072 GB13786 AGAP002393 AAEL007481 PB20988 PHUM283340 GLEAN_12326
Synonyms & Secondary IDs ( 4 )
Reported As
Symbol Synonym	CG9620 (Roos et al., 2002, Luehn et al., 2004, Inlow and Restifo, 2004, Keleman et al., 2009.8.5) gfr (Ishikawa, 2005.3.7, Ishikawa et al., 2005) Gfr (Ishikawa et al., 2005, Vinci et al., 2008, Ishikawa et al., 2010)
Name Synonym	Gfr   Golgi GDP-fucose transporter (Ishikawa et al., 2005, Ishikawa et al., 2010)
Secondary FlyBase IDs
References ( 18 )
Research paper	Ishikawa et al., 2010, J. Biol. Chem. 285(6): 4122--4129 Two pathways for importing GDP-fucose into the endoplasmic reticulum lumen function redundantly in the O-fucosylation of Notch in Drosophila. [FBrf0209841] Vinci et al., 2008, PLoS ONE 3(8): e2883 Preservation of genes involved in sterol metabolism in cholesterol auxotrophs: facts and hypotheses. [FBrf0205755] Ishikawa et al., 2005, Proc. Natl. Acad. Sci. USA 102(51): 18532--18537 Notch deficiency implicated in the pathogenesis of congenital disorder of glycosylation IIc. [FBrf0191442] Inlow and Restifo, 2004, Genetics 166(2): 835--881 Molecular and comparative genetics of mental retardation. [FBrf0174714] Luehn et al., 2004, Exp. Cell Res. 301(2): 242--250 Identification and molecular cloning of a functional GDP-fucose transporter in Drosophila melanogaster. [FBrf0179798]
Supplementary material	The modENCODE Consortium, 2010, Science 330(6012): DataS14: Gene co-expression clusters. [FBrf0213979] Mummery-Widmer et al., 2009, Nature 458(7241): Supplementary Table 2 - Genome-wide bristle screen results. [FBrf0214518]
Review	Roos et al., 2002, J. Biol. Chem. 277(5): 3168--3175 Composition of Drosophila melanogaster proteome involved in fucosylated glycan metabolism. [FBrf0144936]
Personal communication to FlyBase	Keleman et al., 2009.8.5, RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0208510] Dickson et al., 2007.7.18, RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0200327] Ishikawa, 2005.3.7, Helping FlyBase: ADRC-50099. Helping FlyBase: ADRC-50099. [FBrf0182964] Ryder, 2004.4.26, Exelixis CG deletion data. Exelixis CG deletion data. [FBrf0184335]
Abstract	Ishikawa et al., 2005, A. Dros. Res. Conf. 46: 936C A Drosophila model for human congenital disorder of glycosylations IIc. [FBrf0182965]
FlyBase analysis	FlyBase, 1992-, FlyBase curation FlyBase curation. [FBrf0105495]
Protein sequence record	Swiss-Prot Project Members, 2002.3.1, UniProtKB: Q9VHT4 Probable GDP-fucose transporter. [FBrf0151117]
Computer file	Gene Disruption Project members, 2001-, [title not yet available] [title not yet available] [FBrf0132177] BDGP Project Members, 2000-, Berkeley Drosophila Genome Project. Berkeley Drosophila Genome Project. [FBrf0125078]