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Gene Dmel\eIF4AIII

General Information
Symbol	Dmel\eIF4AIII	Species	D. melanogaster
Name	eIF4AIII	Annotation symbol	CG7483
Feature type	protein_coding_gene	FlyBase ID	FBgn0037573
Gene Model Status	Current	Stock availability	8 publicly available
Genomic Location
Chromosome (arm)	3R	Recombination map
Cytogenetic map	84F11-84F11	Sequence location	3R:4,138,930..4,140,586 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene eIF4AIII is referred to in FlyBase by the symbol Dmel\eIF4AIII (CG7483, FBgn0037573). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: protein binding. There is experimental evidence that it is involved in the biological process: response to DNA damage stimulus; pole plasm oskar mRNA localization; RNA splicing. 9 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: DNA/RNA helicase, DEAD/DEAH box type, N-terminal; Helicase, C-terminal; Helicase, superfamily 1/2, ATP-binding domain; RNA helicase, ATP-dependent, DEAD-box, conserved site; RNA helicase, DEAD-box type, Q motif. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderately high expression. Peak expression observed within 00-18 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: larval central nervous system, larval salivary gland, larval trachea, adult ovary, larval carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, adult salivary gland, adult spermathecae, adult male reproductive system, adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1641498_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of eIF4AIII. Gene sequence location is 3R:4138930..4140586.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 84F11-84F11   Limits computationally determined from genome sequence between P{PZ}Mcm2rL074 and P{EP}EP833
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\eIF4AIII for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.49
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) eIF4AIII-RA FBtr0081834  NM_141531   1481   399
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein eIF4AIII-PA   FBpp0081324   45.6   399   5.82     NP_649788   AAF54221
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • RNA helicase, ATP-dependent, DEAD-box, conserved site (IPR000629) Helicase, C-terminal (IPR001650) DNA/RNA helicase, DEAD/DEAH box type, N-terminal (IPR011545) Helicase, superfamily 1/2, ATP-binding domain (IPR014001) RNA helicase, DEAD-box type, Q motif (IPR014014) P-loop containing nucleoside triphosphate hydrolase (IPR027417)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA246570   AA263804   AA817394   AA821180   AA940976   AA942412   AA979377   AA979572   AE014297 AAF54221   AI389691   AI403121   AI404582   AI456899   AI456921   AI513869   AX094240   AY089635 AAL90373   BI169368   BI215052   BI215189   BI230727   BI241187   BI353927   BI355289   BI355702   BI356688   BI365120   BI484587   BI484749   BI486307   BI486566   BI487175   BI563822   BI579474   BI584326   BI635900   BI638559   BI638751   BP542839   BP542840   BP546221   BQ102702   BT133445   BX009164   BX009924   BX021193   BX026914   BX032723   BX047039   BX066432   CL943615   CO177704   CO188551   CO268475   CO274619   CO280340   CO306595   CO307033   CO324339   CO327221   CO327640   CO343686   EC052165   EC055602   EC056561   EC059572   EC088333   EC088473   EC199326   EC220942   EC223771   EC226386   EC228964   EC260637   EV582290   GH950931   GH954427   GH954524   GH958960   GH959870   GH963637   GH963905   GH966346   GH966374   GH967014   GH968715   GH983278   GH983945
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9VHS8 Q8SXH3
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 3   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 4 -- 6   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 7 -- 8   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 9 -- 10   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 11 -- 12   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 13 -- 16   organism | ubiquitous   (Fisher et al., 2012)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
catalytic step 2 spliceosome inferred from direct assay (Herold et al., 2009) nucleus inferred from direct assay (Palacios et al., 2004) pole plasm inferred from direct assay (Palacios et al., 2004) precatalytic spliceosome inferred from direct assay (Herold et al., 2009)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: larval central nervous system, larval salivary gland, larval trachea, adult ovary, larval carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, adult salivary gland, adult spermathecae, adult male reproductive system, adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    931.25 Larval Midgut    286.2 Larval Hindgut    376.4 Larval Malpighian Tubules    402.3 Larval Fat Body    318.9 Larval Salivary Gland    757.7 Larval Trachea    597.25 Larval Carcass    572.325 Adult Head    366.4 Adult Eye    424.025 Adult Brain    393.8 Adult Thoracic-Abdominal Ganglion    387.4 Adult Crop    450.8 Adult Midgut    386.5 Adult Hindgut    336.8 Adult Malpighian Tubules    281.7 Adult Fat Body    257.7 Adult Salivary Gland    457 Adult Heart    276.35 Adult VirginFemale Spermatheca    378.2 Adult InseminatedFemale Spermatheca    427.3 Adult Ovary    765.3 Adult Testis    253.7 Adult Male Accessory Gland    498.5 Adult Carcass    286.1 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (931.25) Larval Midgut    286.2 Larval Hindgut    376.4 Larval Malpighian Tubules    402.3 Larval Fat Body    318.9 Larval Salivary Gland  (757.7) Larval Trachea  (597.25) Larval Carcass  (572.325) Adult Head    366.4 Adult Eye    424.025 Adult Brain    393.8 Adult Thoracic-Abdominal Ganglion    387.4 Adult Crop    450.8 Adult Midgut    386.5 Adult Hindgut    336.8 Adult Malpighian Tubules    281.7 Adult Fat Body    257.7 Adult Salivary Gland    457 Adult Heart    276.35 Adult VirginFemale Spermatheca    378.2 Adult InseminatedFemale Spermatheca    427.3 Adult Ovary  (765.3) Adult Testis    253.7 Adult Male Accessory Gland    498.5 Adult Carcass    286.1 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    931.25 Larval Midgut    286.2 Larval Hindgut    376.4 Larval Malpighian Tubules    402.3 Larval Fat Body    318.9 Larval Salivary Gland    757.7 Larval Trachea    597.25 Larval Carcass    572.325 Adult Head    366.4 Adult Eye    424.025 Adult Brain    393.8 Adult Thoracic-Abdominal Ganglion    387.4 Adult Crop    450.8 Adult Midgut    386.5 Adult Hindgut    336.8 Adult Malpighian Tubules    281.7 Adult Fat Body    257.7 Adult Salivary Gland    457 Adult Heart    276.35 Adult VirginFemale Spermatheca    378.2 Adult InseminatedFemale Spermatheca    427.3 Adult Ovary    765.3 Adult Testis    253.7 Adult Male Accessory Gland    498.5 Adult Carcass    286.1 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    931.25 Larval Midgut    286.2 Larval Hindgut    376.4 Larval Malpighian Tubules    402.3 Larval Fat Body    318.9 Larval Salivary Gland    757.7 Larval Trachea    597.25 Larval Carcass    572.325 Adult Head    366.4 Adult Eye    424.025 Adult Brain    393.8 Adult Thoracic-Abdominal Ganglion    387.4 Adult Crop    450.8 Adult Midgut    386.5 Adult Hindgut    336.8 Adult Malpighian Tubules    281.7 Adult Fat Body    257.7 Adult Salivary Gland    457 Adult Heart    276.35 Adult VirginFemale Spermatheca    378.2 Adult InseminatedFemale Spermatheca    427.3 Adult Ovary    765.3 Adult Testis    253.7 Adult Male Accessory Gland    498.5 Adult Carcass    286.1 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    931.25 Larval Midgut    286.2 Larval Hindgut    376.4 Larval Malpighian Tubules    402.3 Larval Fat Body    318.9 Larval Salivary Gland    757.7 Larval Trachea    597.25 Larval Carcass    572.325 Adult Head    366.4 Adult Eye    424.025 Adult Brain    393.8 Adult Thoracic-Abdominal Ganglion    387.4 Adult Crop    450.8 Adult Midgut    386.5 Adult Hindgut    336.8 Adult Malpighian Tubules    281.7 Adult Fat Body    257.7 Adult Salivary Gland    457 Adult Heart    276.35 Adult VirginFemale Spermatheca    378.2 Adult InseminatedFemale Spermatheca    427.3 Adult Ovary    765.3 Adult Testis    253.7 Adult Male Accessory Gland    498.5 Adult Carcass    286.1 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (931.25) Larval Midgut    286.2 Larval Hindgut    376.4 Larval Malpighian Tubules    402.3 Larval Fat Body    318.9 Larval Salivary Gland  757.7 Larval Trachea  597.25 Larval Carcass  572.325 Adult Head    366.4 Adult Eye    424.025 Adult Brain    393.8 Adult Thoracic-Abdominal Ganglion    387.4 Adult Crop    450.8 Adult Midgut    386.5 Adult Hindgut    336.8 Adult Malpighian Tubules    281.7 Adult Fat Body    257.7 Adult Salivary Gland    457 Adult Heart    276.35 Adult VirginFemale Spermatheca    378.2 Adult InseminatedFemale Spermatheca    427.3 Adult Ovary  765.3 Adult Testis    253.7 Adult Male Accessory Gland    498.5 Adult Carcass    286.1 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    931.25 Larval Midgut    286.2 Larval Hindgut    376.4 Larval Malpighian Tubules    402.3 Larval Fat Body    318.9 Larval Salivary Gland    757.7 Larval Trachea    597.25 Larval Carcass    572.325 Adult Head    366.4 Adult Eye    424.025 Adult Brain    393.8 Adult Thoracic-Abdominal Ganglion    387.4 Adult Crop    450.8 Adult Midgut    386.5 Adult Hindgut    336.8 Adult Malpighian Tubules    281.7 Adult Fat Body    257.7 Adult Salivary Gland    457 Adult Heart    276.35 Adult VirginFemale Spermatheca    378.2 Adult InseminatedFemale Spermatheca    427.3 Adult Ovary    765.3 Adult Testis    253.7 Adult Male Accessory Gland    498.5 Adult Carcass    286.1 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    931.25 Larval Midgut    286.2 Larval Hindgut    376.4 Larval Malpighian Tubules    402.3 Larval Fat Body    318.9 Larval Salivary Gland    757.7 Larval Trachea    597.25 Larval Carcass    572.325 Adult Head    366.4 Adult Eye    424.025 Adult Brain    393.8 Adult Thoracic-Abdominal Ganglion    387.4 Adult Crop    450.8 Adult Midgut    386.5 Adult Hindgut    336.8 Adult Malpighian Tubules    281.7 Adult Fat Body    257.7 Adult Salivary Gland    457 Adult Heart    276.35 Adult VirginFemale Spermatheca    378.2 Adult InseminatedFemale Spermatheca    427.3 Adult Ovary    765.3 Adult Testis    253.7 Adult Male Accessory Gland    498.5 Adult Carcass    286.1 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    366.4   NA  Eye    424.025   NA  Brain    393.8   931.25  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    387.4   NA  Crop    450.8   286.2  Midgut    386.5   376.4  Hindgut    336.8   402.3  Malpighian Tubules    281.7   318.9  Fat Body    257.7   757.7  Salivary Gland    457   NA  Heart    276.35   597.25  Trachea    NA   NA  VirginFemale Spermatheca    378.2   NA  InseminatedFemale Spermatheca    427.3   NA  Ovary    765.3   NA  Testis    253.7   NA  Male Accessory Gland    498.5   572.325  Carcass    286.1 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    69 central nervous system, larvae L3    80 central nervous system, pupae P8    36 head, virgin 1-day female    21 head, virgin 4-day female    20 head, virgin 20-day female    25 head, mated 1-day female    15 head, mated 4-day female    19 head, mated 20-day female    18 head, mated 1-day male    23 head, mated 4-day male    24 head, mated 20-day male    45 salivary gland, larvae L3 wandering    9 salivary gland, white prepupae    13 digestive system, larvae L3 wandering    33 digestive system, 1-day adult    28 digestive system, 4-day adult    22 digestive system, 20-day adult    27 fat body, larvae L3 wandering    6 fat body, white prepupae    21 fat body, pupae P8    26 carcass, larvae L3 wandering    59 carcass, 1-day adult    15 carcass, 4-day adult    22 carcass, 20-day adult    18 ovary, virgin 4-day female    95 ovary, mated 4-day female    75 testis, mated 4-day male    63 accessory gland, mated 4-day male    27 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (69) central nervous system, larvae L3  (80) central nervous system, pupae P8  (36) head, virgin 1-day female    21 head, virgin 4-day female    20 head, virgin 20-day female    25 head, mated 1-day female    15 head, mated 4-day female    19 head, mated 20-day female    18 head, mated 1-day male    23 head, mated 4-day male    24 head, mated 20-day male  (45) salivary gland, larvae L3 wandering    9 salivary gland, white prepupae    13 digestive system, larvae L3 wandering  (33) digestive system, 1-day adult  (28) digestive system, 4-day adult    22 digestive system, 20-day adult  (27) fat body, larvae L3 wandering    6 fat body, white prepupae    21 fat body, pupae P8  26 carcass, larvae L3 wandering  (59) carcass, 1-day adult    15 carcass, 4-day adult    22 carcass, 20-day adult    18 ovary, virgin 4-day female  (95) ovary, mated 4-day female  (75) testis, mated 4-day male  (63) accessory gland, mated 4-day male  (27) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    69 central nervous system, larvae L3    80 central nervous system, pupae P8    36 head, virgin 1-day female    21 head, virgin 4-day female    20 head, virgin 20-day female    25 head, mated 1-day female    15 head, mated 4-day female    19 head, mated 20-day female    18 head, mated 1-day male    23 head, mated 4-day male    24 head, mated 20-day male    45 salivary gland, larvae L3 wandering    9 salivary gland, white prepupae    13 digestive system, larvae L3 wandering    33 digestive system, 1-day adult    28 digestive system, 4-day adult    22 digestive system, 20-day adult    27 fat body, larvae L3 wandering    6 fat body, white prepupae    21 fat body, pupae P8    26 carcass, larvae L3 wandering    59 carcass, 1-day adult    15 carcass, 4-day adult    22 carcass, 20-day adult    18 ovary, virgin 4-day female    95 ovary, mated 4-day female    75 testis, mated 4-day male    63 accessory gland, mated 4-day male    27 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    69 central nervous system, larvae L3    80 central nervous system, pupae P8    36 head, virgin 1-day female    21 head, virgin 4-day female    20 head, virgin 20-day female    25 head, mated 1-day female    15 head, mated 4-day female    19 head, mated 20-day female    18 head, mated 1-day male    23 head, mated 4-day male    24 head, mated 20-day male    45 salivary gland, larvae L3 wandering    9 salivary gland, white prepupae    13 digestive system, larvae L3 wandering    33 digestive system, 1-day adult    28 digestive system, 4-day adult    22 digestive system, 20-day adult    27 fat body, larvae L3 wandering    6 fat body, white prepupae    21 fat body, pupae P8    26 carcass, larvae L3 wandering    59 carcass, 1-day adult    15 carcass, 4-day adult    22 carcass, 20-day adult    18 ovary, virgin 4-day female    95 ovary, mated 4-day female    75 testis, mated 4-day male    63 accessory gland, mated 4-day male    27 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    69 central nervous system, larvae L3    80 central nervous system, pupae P8    36 head, virgin 1-day female    21 head, virgin 4-day female    20 head, virgin 20-day female    25 head, mated 1-day female    15 head, mated 4-day female    19 head, mated 20-day female    18 head, mated 1-day male    23 head, mated 4-day male    24 head, mated 20-day male    45 salivary gland, larvae L3 wandering    9 salivary gland, white prepupae    13 digestive system, larvae L3 wandering    33 digestive system, 1-day adult    28 digestive system, 4-day adult    22 digestive system, 20-day adult    27 fat body, larvae L3 wandering    6 fat body, white prepupae    21 fat body, pupae P8    26 carcass, larvae L3 wandering    59 carcass, 1-day adult    15 carcass, 4-day adult    22 carcass, 20-day adult    18 ovary, virgin 4-day female    95 ovary, mated 4-day female    75 testis, mated 4-day male    63 accessory gland, mated 4-day male    27 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (69) central nervous system, larvae L3  (80) central nervous system, pupae P8  (36) head, virgin 1-day female    21 head, virgin 4-day female    20 head, virgin 20-day female    25 head, mated 1-day female    15 head, mated 4-day female    19 head, mated 20-day female    18 head, mated 1-day male    23 head, mated 4-day male    24 head, mated 20-day male  (45) salivary gland, larvae L3 wandering    9 salivary gland, white prepupae    13 digestive system, larvae L3 wandering  (33) digestive system, 1-day adult  28 digestive system, 4-day adult    22 digestive system, 20-day adult  27 fat body, larvae L3 wandering    6 fat body, white prepupae    21 fat body, pupae P8  26 carcass, larvae L3 wandering  (59) carcass, 1-day adult    15 carcass, 4-day adult    22 carcass, 20-day adult    18 ovary, virgin 4-day female  (95) ovary, mated 4-day female  (75) testis, mated 4-day male  (63) accessory gland, mated 4-day male  27 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    69 central nervous system, larvae L3    80 central nervous system, pupae P8    36 head, virgin 1-day female    21 head, virgin 4-day female    20 head, virgin 20-day female    25 head, mated 1-day female    15 head, mated 4-day female    19 head, mated 20-day female    18 head, mated 1-day male    23 head, mated 4-day male    24 head, mated 20-day male    45 salivary gland, larvae L3 wandering    9 salivary gland, white prepupae    13 digestive system, larvae L3 wandering    33 digestive system, 1-day adult    28 digestive system, 4-day adult    22 digestive system, 20-day adult    27 fat body, larvae L3 wandering    6 fat body, white prepupae    21 fat body, pupae P8    26 carcass, larvae L3 wandering    59 carcass, 1-day adult    15 carcass, 4-day adult    22 carcass, 20-day adult    18 ovary, virgin 4-day female    95 ovary, mated 4-day female    75 testis, mated 4-day male    63 accessory gland, mated 4-day male    27 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    69 central nervous system, larvae L3    80 central nervous system, pupae P8    36 head, virgin 1-day female    21 head, virgin 4-day female    20 head, virgin 20-day female    25 head, mated 1-day female    15 head, mated 4-day female    19 head, mated 20-day female    18 head, mated 1-day male    23 head, mated 4-day male    24 head, mated 20-day male    45 salivary gland, larvae L3 wandering    9 salivary gland, white prepupae    13 digestive system, larvae L3 wandering    33 digestive system, 1-day adult    28 digestive system, 4-day adult    22 digestive system, 20-day adult    27 fat body, larvae L3 wandering    6 fat body, white prepupae    21 fat body, pupae P8    26 carcass, larvae L3 wandering    59 carcass, 1-day adult    15 carcass, 4-day adult    22 carcass, 20-day adult    18 ovary, virgin 4-day female    95 ovary, mated 4-day female    75 testis, mated 4-day male    63 accessory gland, mated 4-day male    27 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderately high expression. Peak expression observed within 00-18 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    155 embryo 02-04hr    280 embryo 04-06hr    299 embryo 06-08hr    247 embryo 08-10hr    242 embryo 10-12hr    256 embryo 12-14hr    131 embryo 14-16hr    139 embryo 16-18hr    90 embryo 18-20hr    48 embryo 20-22hr    68 embryo 22-24hr    59 larva L1    79 larva L2    66 larva L3 12hr old    46 larva L3 puffstage 1-2    45 larva L3 puffstage 3-6    51 larva L3 puffstage 7-9    58 white prepupae new    59 white prepupae 12hr    62 white prepupae 24hr    68 pupae 2d postWPP    55 pupae 3d postWPP    32 pupae 4d postWPP    33 adult male 01day    29 adult male 05day    38 adult male 30day    44 adult female 01day    83 adult female 05day    88 adult female 30day    88 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (155) embryo 02-04hr  (280) embryo 04-06hr  (299) embryo 06-08hr  (247) embryo 08-10hr  (242) embryo 10-12hr  (256) embryo 12-14hr  (131) embryo 14-16hr  (139) embryo 16-18hr  (90) embryo 18-20hr  (48) embryo 20-22hr  (68) embryo 22-24hr  (59) larva L1  (79) larva L2  (66) larva L3 12hr old  (46) larva L3 puffstage 1-2  (45) larva L3 puffstage 3-6  (51) larva L3 puffstage 7-9  (58) white prepupae new  (59) white prepupae 12hr  (62) white prepupae 24hr  (68) pupae 2d postWPP  (55) pupae 3d postWPP  (32) pupae 4d postWPP  (33) adult male 01day  (29) adult male 05day  (38) adult male 30day  (44) adult female 01day  (83) adult female 05day  (88) adult female 30day  (88) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  (155) embryo 02-04hr  (280) embryo 04-06hr  (299) embryo 06-08hr  (247) embryo 08-10hr  (242) embryo 10-12hr  (256) embryo 12-14hr  (131) embryo 14-16hr  (139) embryo 16-18hr    90 embryo 18-20hr    48 embryo 20-22hr    68 embryo 22-24hr    59 larva L1    79 larva L2    66 larva L3 12hr old    46 larva L3 puffstage 1-2    45 larva L3 puffstage 3-6    51 larva L3 puffstage 7-9    58 white prepupae new    59 white prepupae 12hr    62 white prepupae 24hr    68 pupae 2d postWPP    55 pupae 3d postWPP    32 pupae 4d postWPP    33 adult male 01day    29 adult male 05day    38 adult male 30day    44 adult female 01day    83 adult female 05day    88 adult female 30day    88 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    155 embryo 02-04hr    280 embryo 04-06hr    299 embryo 06-08hr    247 embryo 08-10hr    242 embryo 10-12hr    256 embryo 12-14hr    131 embryo 14-16hr    139 embryo 16-18hr    90 embryo 18-20hr    48 embryo 20-22hr    68 embryo 22-24hr    59 larva L1    79 larva L2    66 larva L3 12hr old    46 larva L3 puffstage 1-2    45 larva L3 puffstage 3-6    51 larva L3 puffstage 7-9    58 white prepupae new    59 white prepupae 12hr    62 white prepupae 24hr    68 pupae 2d postWPP    55 pupae 3d postWPP    32 pupae 4d postWPP    33 adult male 01day    29 adult male 05day    38 adult male 30day    44 adult female 01day    83 adult female 05day    88 adult female 30day    88 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    155 embryo 02-04hr    280 embryo 04-06hr    299 embryo 06-08hr    247 embryo 08-10hr    242 embryo 10-12hr    256 embryo 12-14hr    131 embryo 14-16hr    139 embryo 16-18hr    90 embryo 18-20hr    48 embryo 20-22hr    68 embryo 22-24hr    59 larva L1    79 larva L2    66 larva L3 12hr old    46 larva L3 puffstage 1-2    45 larva L3 puffstage 3-6    51 larva L3 puffstage 7-9    58 white prepupae new    59 white prepupae 12hr    62 white prepupae 24hr    68 pupae 2d postWPP    55 pupae 3d postWPP    32 pupae 4d postWPP    33 adult male 01day    29 adult male 05day    38 adult male 30day    44 adult female 01day    83 adult female 05day    88 adult female 30day    88 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (155) embryo 02-04hr  (280) embryo 04-06hr  (299) embryo 06-08hr  (247) embryo 08-10hr  (242) embryo 10-12hr  (256) embryo 12-14hr  (131) embryo 14-16hr  (139) embryo 16-18hr  (90) embryo 18-20hr  (48) embryo 20-22hr  (68) embryo 22-24hr  (59) larva L1  (79) larva L2  (66) larva L3 12hr old  (46) larva L3 puffstage 1-2  (45) larva L3 puffstage 3-6  (51) larva L3 puffstage 7-9  (58) white prepupae new  (59) white prepupae 12hr  (62) white prepupae 24hr  (68) pupae 2d postWPP  (55) pupae 3d postWPP  32 pupae 4d postWPP  (33) adult male 01day  29 adult male 05day  (38) adult male 30day  (44) adult female 01day  (83) adult female 05day  (88) adult female 30day  (88) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  (155) embryo 02-04hr  (280) embryo 04-06hr  (299) embryo 06-08hr  (247) embryo 08-10hr  (242) embryo 10-12hr  (256) embryo 12-14hr  131 embryo 14-16hr  139 embryo 16-18hr    90 embryo 18-20hr    48 embryo 20-22hr    68 embryo 22-24hr    59 larva L1    79 larva L2    66 larva L3 12hr old    46 larva L3 puffstage 1-2    45 larva L3 puffstage 3-6    51 larva L3 puffstage 7-9    58 white prepupae new    59 white prepupae 12hr    62 white prepupae 24hr    68 pupae 2d postWPP    55 pupae 3d postWPP    32 pupae 4d postWPP    33 adult male 01day    29 adult male 05day    38 adult male 30day    44 adult female 01day    83 adult female 05day    88 adult female 30day    88 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    155 embryo 02-04hr    280 embryo 04-06hr    299 embryo 06-08hr    247 embryo 08-10hr    242 embryo 10-12hr    256 embryo 12-14hr    131 embryo 14-16hr    139 embryo 16-18hr    90 embryo 18-20hr    48 embryo 20-22hr    68 embryo 22-24hr    59 larva L1    79 larva L2    66 larva L3 12hr old    46 larva L3 puffstage 1-2    45 larva L3 puffstage 3-6    51 larva L3 puffstage 7-9    58 white prepupae new    59 white prepupae 12hr    62 white prepupae 24hr    68 pupae 2d postWPP    55 pupae 3d postWPP    32 pupae 4d postWPP    33 adult male 01day    29 adult male 05day    38 adult male 30day    44 adult female 01day    83 adult female 05day    88 adult female 30day    88 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    189 Schneider line 2 Sg4    166 embryonic 1182-4H    111 embryonic GM2    82 embryonic Kc167    53 embryonic S1    124 embryonic S3    132 leg disc CME L1    150 wing disc CME-W2    76 wing disc ML-DmD8    70 wing disc ML-DmD9    107 wing disc ML-DmD16-c3    99 wing disc ML-DmD21    234 wing disc ML-DmD32    77 haltere disc ML-DmD17-c3    134 eye-antennal disc ML-DmD11    123 antennal disc ML-DmD20-c5    166 mixed discs ML-DmD4-c1    102 CNS ML-DmBG1-c1    84 CNS ML-DmBG2-c2    76 tumorous blood cells mbn2    91 ovary fGS/OSS    124 ovary OSC    86 ovary OSS    45 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (189) Schneider line 2 Sg4  (166) embryonic 1182-4H  (111) embryonic GM2  (82) embryonic Kc167  (53) embryonic S1  (124) embryonic S3  (132) leg disc CME L1  (150) wing disc CME-W2  (76) wing disc ML-DmD8  (70) wing disc ML-DmD9  (107) wing disc ML-DmD16-c3  (99) wing disc ML-DmD21  (234) wing disc ML-DmD32  (77) haltere disc ML-DmD17-c3  (134) eye-antennal disc ML-DmD11  (123) antennal disc ML-DmD20-c5  (166) mixed discs ML-DmD4-c1  (102) CNS ML-DmBG1-c1  (84) CNS ML-DmBG2-c2  (76) tumorous blood cells mbn2  (91) ovary fGS/OSS  (124) ovary OSC  (86) ovary OSS  (45) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+  (189) Schneider line 2 Sg4  (166) embryonic 1182-4H  (111) embryonic GM2    82 embryonic Kc167    53 embryonic S1  (124) embryonic S3  (132) leg disc CME L1  (150) wing disc CME-W2    76 wing disc ML-DmD8    70 wing disc ML-DmD9  107 wing disc ML-DmD16-c3    99 wing disc ML-DmD21  (234) wing disc ML-DmD32    77 haltere disc ML-DmD17-c3  (134) eye-antennal disc ML-DmD11  (123) antennal disc ML-DmD20-c5  (166) mixed discs ML-DmD4-c1  102 CNS ML-DmBG1-c1    84 CNS ML-DmBG2-c2    76 tumorous blood cells mbn2    91 ovary fGS/OSS  (124) ovary OSC    86 ovary OSS    45 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    189 Schneider line 2 Sg4    166 embryonic 1182-4H    111 embryonic GM2    82 embryonic Kc167    53 embryonic S1    124 embryonic S3    132 leg disc CME L1    150 wing disc CME-W2    76 wing disc ML-DmD8    70 wing disc ML-DmD9    107 wing disc ML-DmD16-c3    99 wing disc ML-DmD21    234 wing disc ML-DmD32    77 haltere disc ML-DmD17-c3    134 eye-antennal disc ML-DmD11    123 antennal disc ML-DmD20-c5    166 mixed discs ML-DmD4-c1    102 CNS ML-DmBG1-c1    84 CNS ML-DmBG2-c2    76 tumorous blood cells mbn2    91 ovary fGS/OSS    124 ovary OSC    86 ovary OSS    45 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    189 Schneider line 2 Sg4    166 embryonic 1182-4H    111 embryonic GM2    82 embryonic Kc167    53 embryonic S1    124 embryonic S3    132 leg disc CME L1    150 wing disc CME-W2    76 wing disc ML-DmD8    70 wing disc ML-DmD9    107 wing disc ML-DmD16-c3    99 wing disc ML-DmD21    234 wing disc ML-DmD32    77 haltere disc ML-DmD17-c3    134 eye-antennal disc ML-DmD11    123 antennal disc ML-DmD20-c5    166 mixed discs ML-DmD4-c1    102 CNS ML-DmBG1-c1    84 CNS ML-DmBG2-c2    76 tumorous blood cells mbn2    91 ovary fGS/OSS    124 ovary OSC    86 ovary OSS    45 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (189) Schneider line 2 Sg4  (166) embryonic 1182-4H  (111) embryonic GM2  (82) embryonic Kc167  (53) embryonic S1  (124) embryonic S3  (132) leg disc CME L1  (150) wing disc CME-W2  (76) wing disc ML-DmD8  (70) wing disc ML-DmD9  (107) wing disc ML-DmD16-c3  (99) wing disc ML-DmD21  (234) wing disc ML-DmD32  (77) haltere disc ML-DmD17-c3  (134) eye-antennal disc ML-DmD11  (123) antennal disc ML-DmD20-c5  (166) mixed discs ML-DmD4-c1  (102) CNS ML-DmBG1-c1  (84) CNS ML-DmBG2-c2  (76) tumorous blood cells mbn2  (91) ovary fGS/OSS  (124) ovary OSC  (86) ovary OSS  (45) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+  (189) Schneider line 2 Sg4  (166) embryonic 1182-4H  111 embryonic GM2    82 embryonic Kc167    53 embryonic S1  124 embryonic S3  132 leg disc CME L1  (150) wing disc CME-W2    76 wing disc ML-DmD8    70 wing disc ML-DmD9  107 wing disc ML-DmD16-c3    99 wing disc ML-DmD21  (234) wing disc ML-DmD32    77 haltere disc ML-DmD17-c3  134 eye-antennal disc ML-DmD11  123 antennal disc ML-DmD20-c5  (166) mixed discs ML-DmD4-c1  102 CNS ML-DmBG1-c1    84 CNS ML-DmBG2-c2    76 tumorous blood cells mbn2    91 ovary fGS/OSS  124 ovary OSC    86 ovary OSS    45 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    189 Schneider line 2 Sg4    166 embryonic 1182-4H    111 embryonic GM2    82 embryonic Kc167    53 embryonic S1    124 embryonic S3    132 leg disc CME L1    150 wing disc CME-W2    76 wing disc ML-DmD8    70 wing disc ML-DmD9    107 wing disc ML-DmD16-c3    99 wing disc ML-DmD21    234 wing disc ML-DmD32    77 haltere disc ML-DmD17-c3    134 eye-antennal disc ML-DmD11    123 antennal disc ML-DmD20-c5    166 mixed discs ML-DmD4-c1    102 CNS ML-DmBG1-c1    84 CNS ML-DmBG2-c2    76 tumorous blood cells mbn2    91 ovary fGS/OSS    124 ovary OSC    86 ovary OSS    45 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    30 cold shock, 4-day adult    25 heat shock, 4-day adult    54 Cadmium 50 mM 6 hrs, larvae L3    56 Cadmium 50 mM 12 hrs, larvae L3    57 Cadmium 50 mM 48 hrs, 4-day adult    37 Cadmium 100 mM 48 hrs, 4-day adult    53 Copper 0.5 mM 12 hrs, larvae L3    33 Copper 15 mM 48 hrs, 4-day adult    26 Zinc 5 mM 12 hrs, larvae L3    31 Zinc 4.5 mM 48 hrs, 4-day adult    21 Ethanol 2.5% 3 hrs, larvae L3    79 Ethanol 5% 3 hrs, larvae L3    45 Ethanol 10% 3 hrs, larvae L3    51 Caffeine 1.5 mg/ml 4 hrs, larvae L3    27 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    49 Caffeine 25 mg/ml 48 hrs, 4-day adult    20 Paraquat 5 mM 48 hrs, 4-day adult    59 Paraquat 10 mM 48 hrs, 4-day adult    58 Rotenone 2 μg 12 hrs, larvae L3    53 Rotenone 8 μg 12 hrs, larvae L3    52 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (30) cold shock, 4-day adult    25 heat shock, 4-day adult  (54) Cadmium 50 mM 6 hrs, larvae L3  (56) Cadmium 50 mM 12 hrs, larvae L3  (57) Cadmium 50 mM 48 hrs, 4-day adult  (37) Cadmium 100 mM 48 hrs, 4-day adult  (53) Copper 0.5 mM 12 hrs, larvae L3  (33) Copper 15 mM 48 hrs, 4-day adult  26 Zinc 5 mM 12 hrs, larvae L3  (31) Zinc 4.5 mM 48 hrs, 4-day adult    21 Ethanol 2.5% 3 hrs, larvae L3  (79) Ethanol 5% 3 hrs, larvae L3  (45) Ethanol 10% 3 hrs, larvae L3  (51) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (27) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (49) Caffeine 25 mg/ml 48 hrs, 4-day adult    20 Paraquat 5 mM 48 hrs, 4-day adult  (59) Paraquat 10 mM 48 hrs, 4-day adult  (58) Rotenone 2 μg 12 hrs, larvae L3  (53) Rotenone 8 μg 12 hrs, larvae L3  (52) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    30 cold shock, 4-day adult    25 heat shock, 4-day adult    54 Cadmium 50 mM 6 hrs, larvae L3    56 Cadmium 50 mM 12 hrs, larvae L3    57 Cadmium 50 mM 48 hrs, 4-day adult    37 Cadmium 100 mM 48 hrs, 4-day adult    53 Copper 0.5 mM 12 hrs, larvae L3    33 Copper 15 mM 48 hrs, 4-day adult    26 Zinc 5 mM 12 hrs, larvae L3    31 Zinc 4.5 mM 48 hrs, 4-day adult    21 Ethanol 2.5% 3 hrs, larvae L3    79 Ethanol 5% 3 hrs, larvae L3    45 Ethanol 10% 3 hrs, larvae L3    51 Caffeine 1.5 mg/ml 4 hrs, larvae L3    27 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    49 Caffeine 25 mg/ml 48 hrs, 4-day adult    20 Paraquat 5 mM 48 hrs, 4-day adult    59 Paraquat 10 mM 48 hrs, 4-day adult    58 Rotenone 2 μg 12 hrs, larvae L3    53 Rotenone 8 μg 12 hrs, larvae L3    52 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    30 cold shock, 4-day adult    25 heat shock, 4-day adult    54 Cadmium 50 mM 6 hrs, larvae L3    56 Cadmium 50 mM 12 hrs, larvae L3    57 Cadmium 50 mM 48 hrs, 4-day adult    37 Cadmium 100 mM 48 hrs, 4-day adult    53 Copper 0.5 mM 12 hrs, larvae L3    33 Copper 15 mM 48 hrs, 4-day adult    26 Zinc 5 mM 12 hrs, larvae L3    31 Zinc 4.5 mM 48 hrs, 4-day adult    21 Ethanol 2.5% 3 hrs, larvae L3    79 Ethanol 5% 3 hrs, larvae L3    45 Ethanol 10% 3 hrs, larvae L3    51 Caffeine 1.5 mg/ml 4 hrs, larvae L3    27 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    49 Caffeine 25 mg/ml 48 hrs, 4-day adult    20 Paraquat 5 mM 48 hrs, 4-day adult    59 Paraquat 10 mM 48 hrs, 4-day adult    58 Rotenone 2 μg 12 hrs, larvae L3    53 Rotenone 8 μg 12 hrs, larvae L3    52 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    30 cold shock, 4-day adult    25 heat shock, 4-day adult    54 Cadmium 50 mM 6 hrs, larvae L3    56 Cadmium 50 mM 12 hrs, larvae L3    57 Cadmium 50 mM 48 hrs, 4-day adult    37 Cadmium 100 mM 48 hrs, 4-day adult    53 Copper 0.5 mM 12 hrs, larvae L3    33 Copper 15 mM 48 hrs, 4-day adult    26 Zinc 5 mM 12 hrs, larvae L3    31 Zinc 4.5 mM 48 hrs, 4-day adult    21 Ethanol 2.5% 3 hrs, larvae L3    79 Ethanol 5% 3 hrs, larvae L3    45 Ethanol 10% 3 hrs, larvae L3    51 Caffeine 1.5 mg/ml 4 hrs, larvae L3    27 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    49 Caffeine 25 mg/ml 48 hrs, 4-day adult    20 Paraquat 5 mM 48 hrs, 4-day adult    59 Paraquat 10 mM 48 hrs, 4-day adult    58 Rotenone 2 μg 12 hrs, larvae L3    53 Rotenone 8 μg 12 hrs, larvae L3    52 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  30 cold shock, 4-day adult    25 heat shock, 4-day adult  (54) Cadmium 50 mM 6 hrs, larvae L3  (56) Cadmium 50 mM 12 hrs, larvae L3  (57) Cadmium 50 mM 48 hrs, 4-day adult  (37) Cadmium 100 mM 48 hrs, 4-day adult  (53) Copper 0.5 mM 12 hrs, larvae L3  (33) Copper 15 mM 48 hrs, 4-day adult  26 Zinc 5 mM 12 hrs, larvae L3  31 Zinc 4.5 mM 48 hrs, 4-day adult    21 Ethanol 2.5% 3 hrs, larvae L3  (79) Ethanol 5% 3 hrs, larvae L3  (45) Ethanol 10% 3 hrs, larvae L3  (51) Caffeine 1.5 mg/ml 4 hrs, larvae L3  27 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (49) Caffeine 25 mg/ml 48 hrs, 4-day adult    20 Paraquat 5 mM 48 hrs, 4-day adult  (59) Paraquat 10 mM 48 hrs, 4-day adult  (58) Rotenone 2 μg 12 hrs, larvae L3  (53) Rotenone 8 μg 12 hrs, larvae L3  (52) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    30 cold shock, 4-day adult    25 heat shock, 4-day adult    54 Cadmium 50 mM 6 hrs, larvae L3    56 Cadmium 50 mM 12 hrs, larvae L3    57 Cadmium 50 mM 48 hrs, 4-day adult    37 Cadmium 100 mM 48 hrs, 4-day adult    53 Copper 0.5 mM 12 hrs, larvae L3    33 Copper 15 mM 48 hrs, 4-day adult    26 Zinc 5 mM 12 hrs, larvae L3    31 Zinc 4.5 mM 48 hrs, 4-day adult    21 Ethanol 2.5% 3 hrs, larvae L3    79 Ethanol 5% 3 hrs, larvae L3    45 Ethanol 10% 3 hrs, larvae L3    51 Caffeine 1.5 mg/ml 4 hrs, larvae L3    27 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    49 Caffeine 25 mg/ml 48 hrs, 4-day adult    20 Paraquat 5 mM 48 hrs, 4-day adult    59 Paraquat 10 mM 48 hrs, 4-day adult    58 Rotenone 2 μg 12 hrs, larvae L3    53 Rotenone 8 μg 12 hrs, larvae L3    52 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    30 cold shock, 4-day adult    25 heat shock, 4-day adult    54 Cadmium 50 mM 6 hrs, larvae L3    56 Cadmium 50 mM 12 hrs, larvae L3    57 Cadmium 50 mM 48 hrs, 4-day adult    37 Cadmium 100 mM 48 hrs, 4-day adult    53 Copper 0.5 mM 12 hrs, larvae L3    33 Copper 15 mM 48 hrs, 4-day adult    26 Zinc 5 mM 12 hrs, larvae L3    31 Zinc 4.5 mM 48 hrs, 4-day adult    21 Ethanol 2.5% 3 hrs, larvae L3    79 Ethanol 5% 3 hrs, larvae L3    45 Ethanol 10% 3 hrs, larvae L3    51 Caffeine 1.5 mg/ml 4 hrs, larvae L3    27 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    49 Caffeine 25 mg/ml 48 hrs, 4-day adult    20 Paraquat 5 mM 48 hrs, 4-day adult    59 Paraquat 10 mM 48 hrs, 4-day adult    58 Rotenone 2 μg 12 hrs, larvae L3    53 Rotenone 8 μg 12 hrs, larvae L3    52 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_17 mE1_20_mRNA_expression_cluster_02
External Data & Images
Linkouts	BDGP expression data • RE50350 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0037573 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG7483-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal eIF4AIII19 lethal | germline clone eIF4AIII19 Other Phenotypes Allele increased cell death | germline clone eIF4AIII19 Phenotype manifest in Allele cytoskeleton & oocyte | germ-line clone eIF4AIII19 nucleus & oocyte | germ-line clone eIF4AIII19 oocyte associated follicle cell | germline clone eIF4AIII19
Classical Alleles ( 3 )
For All Classical Alleles Show
Allele of eIF4AIII Class Mutagen Stocks Known lesion eIF4AIII19 2 Yes eIF4AIIIEY14207 P-element activity 1 -- eIF4AIIIGT-000230 P-element activity 1 --
Alleles Carried on Transgenic Constructs ( 6 )
For All Alleles Carried on Transgenic Constructs Show
Allele of eIF4AIII Class Mutagen Stocks Known lesion eIF4AIIIGL00641 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes eIF4AIIIHMS00442 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes eIF4AIIIHMS00696 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes eIF4AIIIKK101462 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes eIF4AIIIGD12251 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes eIF4AIIIαTub67C.T:Avic\GFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes
Aneuploid Aberrations
Not disrupted in	Df(3R)Antp17 (Baker et al., 1991) Df(3R)Coq21D (Cheng et al., 2011) Df(3R)D7 (Baker et al., 1991) Df(3R)dsx2M (Baker et al., 1991) Df(3R)dsx3 (Baker et al., 1991) Df(3R)dsx10M (Baker et al., 1991) Df(3R)dsx15 (Baker et al., 1991) Df(3R)dsx21 (Baker et al., 1991) Df(3R)dsx29 (Baker et al., 1991) Df(3R)dsx43 (Baker et al., 1991) Df(3R)Poxm85A (Cheng et al., 2011)
Disrupted in	Df(3R)D6 (Baker et al., 1991) Df(3R)dsx2D (Baker et al., 1991) Df(3R)dsx11 (Baker et al., 1991) Df(3R)Exel6147 (Ryder, 2004.4.26) Df(3R)p13 (Baker et al., 1991) Df(3R)p30 (Baker et al., 1991) Df(3R)p40 (Baker et al., 1991)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD12251} NA P{KK101462} NA P{TRiP.GL00641} NA P{TRiP.HMS00442} NA P{TRiP.HMS00696} NA characterization construct P{α4-tubulin-eIF4AIII.GFP} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EPgy2}eIF4AIIIEY14207 NA miscellaneous insertions P{GT1}eIF4AIIIGT-000230 NA
Gene Ontology: Function, Process & Cellular Component ( 14 unique terms )
Terms Based on Experimental Evidence ( 8 terms )
Molecular Function
CV term Evidence References
protein binding inferred from physical interaction with btz (Palacios et al., 2004)
Biological Process
CV term Evidence References
pole plasm oskar mRNA localization inferred from genetic interaction with btz (Palacios et al., 2004) response to DNA damage stimulus inferred from mutant phenotype (Ravi et al., 2009) RNA splicing inferred from mutant phenotype (Ashton-Beaucage et al., 2010)
Cellular Component
CV term Evidence References
catalytic step 2 spliceosome inferred from direct assay (Herold et al., 2009) nucleus inferred from direct assay (Palacios et al., 2004) pole plasm inferred from direct assay (Palacios et al., 2004) precatalytic spliceosome inferred from direct assay (Herold et al., 2009)
Terms Based on Predictions or Assertions ( 6 terms )
Molecular Function
CV term Evidence References
ATP binding inferred from electronic annotation with InterPro:IPR000629, InterPro:IPR001650, InterPro:IPR011545 (FlyBase Curators et al., 2004-) ATP-dependent RNA helicase activity inferred from sequence or structural similarity with Saccharomyces FAL1 (Lasko, 2000) translation initiation factor activity inferred from sequence or structural similarity (Lasko, 2000) inferred from sequence or structural similarity with UniProtKB:P41380 (FlyBase, 1992-)
Biological Process
CV term Evidence References
mRNA splicing, via spliceosome inferred by curator from GO:0071011|GO:0071013 (Herold et al., 2009) translational initiation inferred from sequence or structural similarity (Lasko, 2000)
Cellular Component
CV term Evidence References
eukaryotic translation initiation factor 4F complex inferred from sequence or structural similarity (Lasko, 2000) inferred from sequence or structural similarity with UniProtKB:P41380 (FlyBase, 1992-)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
eIF4AIII - Arpc4 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) eIF4AIII - Ate1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) eIF4AIII - Bx42 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) eIF4AIII - CG10164 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) eIF4AIII - CG10602 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) eIF4AIII - CG10889 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) eIF4AIII - CG1116 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) eIF4AIII - CG12279 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) eIF4AIII - CG12519 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) eIF4AIII - CG12576 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) eIF4AIII - CG12659 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) eIF4AIII - CG1273 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) eIF4AIII - CG14507 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) eIF4AIII - CG15043 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) eIF4AIII - CG15118 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) eIF4AIII - CG17562 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) eIF4AIII - CG31776 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) eIF4AIII - CG32335 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) eIF4AIII - CG3744 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) eIF4AIII - CG3862 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) eIF4AIII - CG3967 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) eIF4AIII - CG42319 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) eIF4AIII - CG4390 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) eIF4AIII - CG4825 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) eIF4AIII - CG4847 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) eIF4AIII - CG5274 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) eIF4AIII - CG5599 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) eIF4AIII - CG5946 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) eIF4AIII - CG6665 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) eIF4AIII - CG6852 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) eIF4AIII - CG7146 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) eIF4AIII - CG7164 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) eIF4AIII - CG7358 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) eIF4AIII - CG7872 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) eIF4AIII - CG8323 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) eIF4AIII - CG8329 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) eIF4AIII - CG8336 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) eIF4AIII - CG8353 experimental knowledge based, anti tag coimmunoprecipitation, peptide massfingerprinting (Guruharsha et al., 2011, Mintseris et al., 2009.11.23) eIF4AIII - CG8671 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) eIF4AIII - Cchl anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) eIF4AIII - Cct5 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) eIF4AIII - Cdk5 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) eIF4AIII - CycC anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) eIF4AIII - CycG anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) eIF4AIII - CycY anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) eIF4AIII - Cyp4c3 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) eIF4AIII - Dad anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) eIF4AIII - Dgk anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) eIF4AIII - E(spl)m7-HLH anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) eIF4AIII - E(spl)mδ-HLH anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) eIF4AIII - EndoG anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) eIF4AIII - Fer2LCH anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) eIF4AIII - GalNAc-T1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) eIF4AIII - Gie anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) eIF4AIII - HDAC6 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) eIF4AIII - Lmpt anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) eIF4AIII - Myd88 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) eIF4AIII - Nup62 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) eIF4AIII - Obp49a anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) eIF4AIII - Obp83ef anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) eIF4AIII - PH4αSG1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) eIF4AIII - Pebp1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) eIF4AIII - Pof anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) eIF4AIII - Pp1-87B anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) eIF4AIII - Prp18 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) eIF4AIII - Prp31 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) eIF4AIII - Rab10 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) eIF4AIII - Rab5 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) eIF4AIII - Rcc1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) eIF4AIII - Rcd5 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) eIF4AIII - Rheb anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) eIF4AIII - Rho1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) eIF4AIII - RpLP0 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) eIF4AIII - Rpb7 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) eIF4AIII - Sdc anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) eIF4AIII - Spt5 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) eIF4AIII - Start1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) eIF4AIII - Stat92E anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) eIF4AIII - Vps25 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) eIF4AIII - WASp anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) eIF4AIII - YL-1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) eIF4AIII - ana2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) eIF4AIII - ap anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) eIF4AIII - bs anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) eIF4AIII - caup anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) eIF4AIII - crn anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) eIF4AIII - exu anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) eIF4AIII - fd102C anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) eIF4AIII - grass anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) eIF4AIII - gro anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) eIF4AIII - hebe anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) eIF4AIII - hep anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) eIF4AIII - l(1)G0469 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) eIF4AIII - lolal anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) eIF4AIII - mTerf5 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) eIF4AIII - metro anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) eIF4AIII - mts anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) eIF4AIII - nct anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) eIF4AIII - p-cup anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) eIF4AIII - poly anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) eIF4AIII - rumi anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) eIF4AIII - stet anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) eIF4AIII - svp anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) eIF4AIII - thoc5 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) eIF4AIII - twe anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) eIF4AIII - twin anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) eIF4AIII - tws anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions eIF4AIII allele Gene References eIF4AIII19 btz (Palacios et al., 2004) unspecified osk (Palacios et al., 2004)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 66168 DroID - A comprehensive database of gene and protein interactions. • FBgn0037573 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 40987
Orthologs
OrthoDB Orthologs (52) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG61VKNV Dipteran inclusive ortholog search EOG6VX2DS Insect inclusive ortholog search EOG6FXQ40 Arthropod inclusive ortholog search EOG6Z08N3 Metazoa inclusive ortholog search EOG63NM66
Orthologs in Drosophila Species (EOG61VKNV)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\eIF4AIII     Drosophila sechellia   Dsec\GM23722 Y   Drosophila erecta   Dere\GG24917 Y   Drosophila yakuba   Dyak\GE25867 Y   Drosophila ananassae   Dana\GF18341 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA20384 Y   Drosophila persimilis   Dper\GL23429 Y   Drosophila willistoni   Dwil\GK13178 Y   Drosophila virilis   Dvir\GJ24512 Y   Drosophila mojavensis   Dmoj\GI24868 Y   Drosophila grimshawi   Dgri\GH14195 Y
Orthologs in non-Drosophila Dipterans (EOG6VX2DS)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL014414   Anopheles gambiae Malaria mosquito  Agam\AGAP003089
Orthologs in non-Dipteran Insects (EOG6FXQ40)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\LOC409866   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG003545   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH15700   Atta cephalotes Leafcutter ant  Acep\ACEP14863   Camponotus floridanus Florida carpenter ant  Cflo\CFLO19070   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL14713   Linepithema humile Argentine ant  Lhum\LH11979   Pogonomyrmex barbatus Red harvester ant  Pbar\PB11348   Solenopsis invicta Red fire ant  Sinv\SINV11863   Acyrthosiphon pisum Pea aphid  Apim\ACYPI001585   Bombyx mori Silkmoth  Bmor\BGIBMGA004822   Pediculus humanus Human body louse  Phum\PHUM597330   Tribolium castaneum Red flour beetle  Tcas\TC009998
Orthologs in non-Insect Arthropods (EOG6Z08N3)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\ACSL4   Ixodes scapularis Deer tick  Isca\ISCW013399
Orthologs in non-Arthropod Metazoa (EOG63NM66)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\Y65B4A.6 Y Caenorhabditis elegans Nematode  Cele\F57B9.3 Y Caenorhabditis elegans Nematode  Cele\inf-1 Y Caenorhabditis elegans Nematode  Cele\F33D11.10 Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_014808gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_023083gn Y Danio rerio Zebrafish  Drer\eif4a2 Y Danio rerio Zebrafish  Drer\eif4a1a Y Danio rerio Zebrafish  Drer\eif4a1b Y Danio rerio Zebrafish  Drer\eif4a3 Y Xenopus tropicalis Western clawed frog  Xtro\eif4a2 Y Xenopus tropicalis Western clawed frog  Xtro\eif4a1 Y Xenopus tropicalis Western clawed frog  Xtro\eif4a3 Y Gallus gallus Domestic chicken  Ggal\EIF4A2 Y Gallus gallus Domestic chicken  Ggal\EIF4A3 Y Mus musculus House mouse  Mmus\Eif4a1 Y Mus musculus House mouse  Mmus\Gm5576 Y Mus musculus House mouse  Mmus\Eif4a3 Y Mus musculus House mouse  Mmus\Gm8994 Y Rattus norvegicus Norway rat  Rnor\Eif4a2 Y Rattus norvegicus Norway rat  Rnor\ENSRNOG00000027316 Y Rattus norvegicus Norway rat  Rnor\Eif4a1 Y Homo sapiens Human  Hsap\EIF4A1 Y Homo sapiens Human  Hsap\EIF4A3 Y
Human Orthologs (2)
Gene OMIM HGNC Hsap\EIF4A1     Hsap\EIF4A3
AAA Orthologs (10) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila sechellia Dsec\GM23722 Drosophila erecta Dere\GG24917 Drosophila yakuba Dyak\GE25867 Drosophila ananassae Dana\GF18341 Drosophila pseudoobscura pseudoobscura Dpse\GA20384 Drosophila persimilis Dper\GL23429 Drosophila willistoni Dwil\GK13178 Drosophila virilis Dvir\GJ24512 Drosophila mojavensis Dmoj\GI24868 Drosophila grimshawi Dgri\GH14195
Stocks & Reagents
Stocks Listed in FlyBase ( 8 )
Bloomington	20978 w1118; P{GT1}eIF4AIIIGT-000230 32444 y1 sc* v1; P{TRiP.HMS00442}attP2 32907 y1 sc* v1; P{TRiP.HMS00696}attP2 38202 y1 sc* v1; P{TRiP.GL00641}attP40 2781 eIF4AIII19 red1 e4/TM3, Sb1 20914 y1 w67c23; P{EPgy2}eIF4AIIIEY14207/TM3, Sb1 Ser1
Kyoto	107466 eIF4AIII19 red1 e4/TM3, Sb1
VDRC	v108580 P{KK101462}VIE-260B
Genomic Clones ( 1 )
	BACR33N15 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 67 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	RE50350
Other clones	FI20117
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH20928 GH22491 GH24347 GM14810 GM25617 GM30238 GM32037 LD05651 LD06942 LD22660 LD23361 LD26611 LD33911 LD34195 LD37064 LD37088 LD45883 RE10523 RE14755 RE21249 RE21529 RE38208 RE42880 RE67714 RE67896 RE69724 RE70014 RE70690 RE73517 RH23504 RH34543 SD17435 SD20872 SD21121
Other clones	Dmel_dig_012741_0601_3440 EC052165 EC055602 EC056561 EK040905 EK054103 EK091610 EK114645 EK153818 EK193258 EK251536 EK253261 EP06502 EP07802 EP17829 FGC017C04 FGH104B02 RP004018090 RP004113301 RP004114588 RP004167081 RP004204531 RP004211304 RP004451213 RP004473379 RP004480314 RP004480584 RP004511969 RP004513259 RP004551777 UUGC0086
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0037573 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 40987
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: eIF4AIII anon-WO0118547.364 (FlyBase, 1996-)
Additional comments	Source for merge of eIF4AIII anon-WO0118547.364 was sequence comparison (date:051113). (FlyBase, 1996-)
Other Comments
	eIF4AIII has a role in the splicing regulation of genes containing long introns. (Ashton-Beaucage et al., 2010) Area matching Drosophila EST AA817394. This EST has sequence similarity to Dead box DNA helicase genes. (Davies, 2001.3.15)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_141531 RefSeq (Proteins) • NP_649788 DDBJ / EMBL / GenBank • AA817394 AAF54221 AAL90373 AX094240 AY089635 BI365120 CL943615 Entrez Gene - A searchable database of RefSeq genes. • 40987 UniProtKB/TrEMBL • Q8SXH3 Q9VHS8
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • RNA helicase, ATP-dependent, DEAD-box, conserved site (IPR000629) Helicase, C-terminal (IPR001650) DNA/RNA helicase, DEAD/DEAH box type, N-terminal (IPR011545) Helicase, superfamily 1/2, ATP-binding domain (IPR014001) RNA helicase, DEAD-box type, Q motif (IPR014014) P-loop containing nucleoside triphosphate hydrolase (IPR027417) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • RE50350
Linkouts
	BioGRID - A database of protein and genetic interactions • 66168 DroID - A comprehensive database of gene and protein interactions. • FBgn0037573 DRSC - Results from RNAi screens. • FBgn0037573 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0037573 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG7483-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0037573 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 40987 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 40987 modMine - Data generated by the modENCODE project. • FBgn0037573
Synonyms & Secondary IDs ( 12 )
Reported As
Symbol Synonym	7483 (Ravi et al., 2009) anon-WO0118547.364   CG7483 (Li et al., 2005, Ryder, 2004.9.23, Palacios et al., 2004, Palacios et al., 2004, Keleman et al., 2009.8.5, Herold et al., 2009, Ni et al., 2010.12.1, Hernandez et al., 2004) DmRH28 (Boudet et al., 2001) eIF4A (Lasko, 2000) eIF4A3 (Zhang and Krainer, 2007) eIF4AIII (Cheng et al., 2011, Stielow et al., 2008, Herold et al., 2009, Roignant and Treisman, 2010, Ashton-Beaucage et al., 2010, Liu et al., 2011, Saulière et al., 2010, Ghosh et al., 2012) EIF4AIII (Ashton-Beaucage and Therrien, 2011, Friedman et al., 2011) eIF4A-III (Hernandez and Vazquez-Pianzola, 2005) l(3)84Fi (Baker et al., 1991, )
Name Synonym	eIF4AIII   eukaryotic translation initiation factor 4AIII (Saulière et al., 2010) lethal(3)84Fi
Secondary FlyBase IDs
	FBgn0004221 FBgn0062067
References ( 44 )
Generate a list of	All references relating to this gene ( 44 )
List References by type	Research paper  ( 19 ) Supplementary material  ( 7 ) Review  ( 2 ) Personal communication to FlyBase  ( 8 ) FlyBase analysis  ( 2 ) Patent  ( 1 ) DNA/RNA sequence record  ( 1 ) Website  ( 1 ) Curated genome annotation  ( 2 ) Book  ( 1 )
Recent research papers ( 4 )
	Ghosh et al., 2012, Nat. Struct. Mol. Biol. 19(4): 441--449 Control of RNP motility and localization by a splicing-dependent structure in oskar mRNA. [FBrf0217905] Ashton-Beaucage and Therrien, 2011, Fly 5(3): 224--233 The exon junction complex: A splicing factor for long intron containing transcripts? [FBrf0214715] Friedman et al., 2011, Sci. Signal. 4(196): rs10 Proteomic and functional genomic landscape of receptor tyrosine kinase and ras to extracellular signal-regulated kinase signaling. [FBrf0216513] Liu et al., 2011, J. Genet. Genomics 38(6): 225--234 Drosophila sbo regulates lifespan through its function in the synthesis of coenzyme Q in vivo. [FBrf0214012] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...