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Gene Dmel\Tcp-1η

General Information
Symbol	Dmel\Tcp-1η	Species	D. melanogaster
Name	Tcp-1η	Annotation symbol	CG8351
Feature type	protein_coding_gene	FlyBase ID	FBgn0037632
Gene Model Status	Current	Stock availability	8 publicly available
Also Known As	Tcp-1eta
Genomic Location
Chromosome (arm)	3R	Recombination map
Cytogenetic map	85B1-85B2	Sequence location	3R:4,627,286..4,631,956 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Tcp-1η is referred to in FlyBase by the symbol Dmel\Tcp-1η (CG8351, FBgn0037632). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: ATPase activity, coupled. There is experimental evidence that it is involved in the biological process: mitotic spindle organization; cytoplasmic microtubule organization; neurogenesis. 12 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: Chaperone, tailless complex polypeptide 1; Chaperonin Cpn60/TCP-1; Chaperonin TCP-1, conserved site; T-complex protein 1, eta subunit. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderately high expression. Peak expression observed within 00-12 hour embryonic stages, during early larval stages, in adult female stages. Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: larval central nervous system, adult crop, larval/adult midgut, larval hindgut, adult Malpighian tubules, larval salivary gland, larval trachea, adult ovary, larval carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, adult central nervous system, adult hindgut, larval Malpighian tubules, adult heart, larval/adult fat body, adult salivary gland, adult spermathecae, adult male reproductive system, adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1626845_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of Tcp-1eta. Gene sequence location is 3R:4627286..4631956.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 85B1-85B2   Limits computationally determined from genome sequence between P{lacW}l(3)L4740L4740 and P{EP}D1EP473
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Tcp-1η for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.47
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Tcp-1η-RA FBtr0081918  NM_141578   1964   544
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Tcp-1η-PA   FBpp0081401   59.4   544   6.27     NP_649835   AAF54292
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Chaperonin TCP-1, conserved site (IPR002194) Chaperonin Cpn60/TCP-1 (IPR002423) T-complex protein 1, eta subunit (IPR012720) Chaperone tailless complex polypeptide 1 (TCP-1) (IPR017998) TCP-1-like chaperonin intermediate domain (IPR027410) GroEL-like apical domain (IPR027409) GroEL-like equatorial domain (IPR027413)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA202292   AA263277   AA391251   AA567919   AA695292   AA695403   AA695762   AA697061   AA735824   AA801983   AE014297 AAF54292   AI515529   AI518530   AI531843   AI531903   AI532784   AI542037   AI546730   AW943896   AY122201 AAM52713   BF487931   BF491528   BF492992   BF492993   BF506066   BG637961   BG641237   BH740736   BI141841   BI141925   BI170858   BI216968   BI238414   BI240694   BI241506   BI352031   BI352137   BI352809   BI353215   BI353772   BI354578   BI355091   BI362655   BI367786   BI482083   BI482153   BI482602   BI486430   BI487081   BI633006   BI633232   BI640350   BP549723   BP549724   BZ665688   CK605087   CK605088   CK605191   CK661697   CO262180   CO277638   CO280601   CO283305   CO285342   CO291271   CO296733   CO308664   CO308862   CO310318   CO310615   CO311158   CO312822   CO317262   CO317698   CZ467981   EC061895   EC064766   EC071776   EC077717   EC081542   EC084132   EC087248   EC199508   EC224285   EC225529   EC236578   EC237484   EC238598   EC244528   EC248000   EC249618   EC249966
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9VHL2
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 7 of adulthood -- day 49 of adulthood   adult heart   (Cammarato et al., 2011)
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
microtubule associated complex inferred from direct assay (Hughes et al., 2008)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: larval central nervous system, adult crop, larval/adult midgut, larval hindgut, adult Malpighian tubules, larval salivary gland, larval trachea, adult ovary, larval carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, adult central nervous system, adult hindgut, larval Malpighian tubules, adult heart, larval/adult fat body, adult salivary gland, adult spermathecae, adult male reproductive system, adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    981.05 Larval Midgut    532.7 Larval Hindgut    693.1 Larval Malpighian Tubules    362.3 Larval Fat Body    307.4 Larval Salivary Gland    791.4 Larval Trachea    1174 Larval Carcass    856.7 Adult Head    266.6 Adult Eye    278.85 Adult Brain    178.3 Adult Thoracic-Abdominal Ganglion    228.9 Adult Crop    589.4 Adult Midgut    581 Adult Hindgut    440.8 Adult Malpighian Tubules    588.2 Adult Fat Body    295.4 Adult Salivary Gland    247.5 Adult Heart    382.75 Adult VirginFemale Spermatheca    277 Adult InseminatedFemale Spermatheca    371.8 Adult Ovary    1255 Adult Testis    283.6 Adult Male Accessory Gland    346.7 Adult Carcass    213.3 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (981.05) Larval Midgut  532.7 Larval Hindgut  (693.1) Larval Malpighian Tubules    362.3 Larval Fat Body    307.4 Larval Salivary Gland  (791.4) Larval Trachea  (1174) Larval Carcass  (856.7) Adult Head    266.6 Adult Eye    278.85 Adult Brain    178.3 Adult Thoracic-Abdominal Ganglion    228.9 Adult Crop  (589.4) Adult Midgut  (581) Adult Hindgut    440.8 Adult Malpighian Tubules  (588.2) Adult Fat Body    295.4 Adult Salivary Gland    247.5 Adult Heart    382.75 Adult VirginFemale Spermatheca    277 Adult InseminatedFemale Spermatheca    371.8 Adult Ovary  (1255) Adult Testis    283.6 Adult Male Accessory Gland    346.7 Adult Carcass    213.3 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    981.05 Larval Midgut    532.7 Larval Hindgut    693.1 Larval Malpighian Tubules    362.3 Larval Fat Body    307.4 Larval Salivary Gland    791.4 Larval Trachea  (1174) Larval Carcass    856.7 Adult Head    266.6 Adult Eye    278.85 Adult Brain    178.3 Adult Thoracic-Abdominal Ganglion    228.9 Adult Crop    589.4 Adult Midgut    581 Adult Hindgut    440.8 Adult Malpighian Tubules    588.2 Adult Fat Body    295.4 Adult Salivary Gland    247.5 Adult Heart    382.75 Adult VirginFemale Spermatheca    277 Adult InseminatedFemale Spermatheca    371.8 Adult Ovary  (1255) Adult Testis    283.6 Adult Male Accessory Gland    346.7 Adult Carcass    213.3 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    981.05 Larval Midgut    532.7 Larval Hindgut    693.1 Larval Malpighian Tubules    362.3 Larval Fat Body    307.4 Larval Salivary Gland    791.4 Larval Trachea    1174 Larval Carcass    856.7 Adult Head    266.6 Adult Eye    278.85 Adult Brain    178.3 Adult Thoracic-Abdominal Ganglion    228.9 Adult Crop    589.4 Adult Midgut    581 Adult Hindgut    440.8 Adult Malpighian Tubules    588.2 Adult Fat Body    295.4 Adult Salivary Gland    247.5 Adult Heart    382.75 Adult VirginFemale Spermatheca    277 Adult InseminatedFemale Spermatheca    371.8 Adult Ovary    1255 Adult Testis    283.6 Adult Male Accessory Gland    346.7 Adult Carcass    213.3 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    981.05 Larval Midgut    532.7 Larval Hindgut    693.1 Larval Malpighian Tubules    362.3 Larval Fat Body    307.4 Larval Salivary Gland    791.4 Larval Trachea    1174 Larval Carcass    856.7 Adult Head    266.6 Adult Eye    278.85 Adult Brain    178.3 Adult Thoracic-Abdominal Ganglion    228.9 Adult Crop    589.4 Adult Midgut    581 Adult Hindgut    440.8 Adult Malpighian Tubules    588.2 Adult Fat Body    295.4 Adult Salivary Gland    247.5 Adult Heart    382.75 Adult VirginFemale Spermatheca    277 Adult InseminatedFemale Spermatheca    371.8 Adult Ovary    1255 Adult Testis    283.6 Adult Male Accessory Gland    346.7 Adult Carcass    213.3 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (981.05) Larval Midgut  532.7 Larval Hindgut  693.1 Larval Malpighian Tubules    362.3 Larval Fat Body    307.4 Larval Salivary Gland  791.4 Larval Trachea  (1174) Larval Carcass  (856.7) Adult Head    266.6 Adult Eye    278.85 Adult Brain    178.3 Adult Thoracic-Abdominal Ganglion    228.9 Adult Crop  589.4 Adult Midgut  581 Adult Hindgut    440.8 Adult Malpighian Tubules  588.2 Adult Fat Body    295.4 Adult Salivary Gland    247.5 Adult Heart    382.75 Adult VirginFemale Spermatheca    277 Adult InseminatedFemale Spermatheca    371.8 Adult Ovary  (1255) Adult Testis    283.6 Adult Male Accessory Gland    346.7 Adult Carcass    213.3 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    981.05 Larval Midgut    532.7 Larval Hindgut    693.1 Larval Malpighian Tubules    362.3 Larval Fat Body    307.4 Larval Salivary Gland    791.4 Larval Trachea  1174 Larval Carcass    856.7 Adult Head    266.6 Adult Eye    278.85 Adult Brain    178.3 Adult Thoracic-Abdominal Ganglion    228.9 Adult Crop    589.4 Adult Midgut    581 Adult Hindgut    440.8 Adult Malpighian Tubules    588.2 Adult Fat Body    295.4 Adult Salivary Gland    247.5 Adult Heart    382.75 Adult VirginFemale Spermatheca    277 Adult InseminatedFemale Spermatheca    371.8 Adult Ovary  1255 Adult Testis    283.6 Adult Male Accessory Gland    346.7 Adult Carcass    213.3 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    981.05 Larval Midgut    532.7 Larval Hindgut    693.1 Larval Malpighian Tubules    362.3 Larval Fat Body    307.4 Larval Salivary Gland    791.4 Larval Trachea    1174 Larval Carcass    856.7 Adult Head    266.6 Adult Eye    278.85 Adult Brain    178.3 Adult Thoracic-Abdominal Ganglion    228.9 Adult Crop    589.4 Adult Midgut    581 Adult Hindgut    440.8 Adult Malpighian Tubules    588.2 Adult Fat Body    295.4 Adult Salivary Gland    247.5 Adult Heart    382.75 Adult VirginFemale Spermatheca    277 Adult InseminatedFemale Spermatheca    371.8 Adult Ovary    1255 Adult Testis    283.6 Adult Male Accessory Gland    346.7 Adult Carcass    213.3 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    266.6   NA  Eye    278.85   NA  Brain    178.3   981.05  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    228.9   NA  Crop    589.4   532.7  Midgut    581   693.1  Hindgut    440.8   362.3  Malpighian Tubules    588.2   307.4  Fat Body    295.4   791.4  Salivary Gland    247.5   NA  Heart    382.75   1174  Trachea    NA   NA  VirginFemale Spermatheca    277   NA  InseminatedFemale Spermatheca    371.8   NA  Ovary    1255   NA  Testis    283.6   NA  Male Accessory Gland    346.7   856.7  Carcass    213.3 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    124 central nervous system, larvae L3    90 central nervous system, pupae P8    27 head, virgin 1-day female    10 head, virgin 4-day female    12 head, virgin 20-day female    14 head, mated 1-day female    8 head, mated 4-day female    20 head, mated 20-day female    12 head, mated 1-day male    12 head, mated 4-day male    13 head, mated 20-day male    21 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    13 digestive system, larvae L3 wandering    36 digestive system, 1-day adult    28 digestive system, 4-day adult    38 digestive system, 20-day adult    41 fat body, larvae L3 wandering    8 fat body, white prepupae    23 fat body, pupae P8    23 carcass, larvae L3 wandering    84 carcass, 1-day adult    17 carcass, 4-day adult    27 carcass, 20-day adult    24 ovary, virgin 4-day female    164 ovary, mated 4-day female    146 testis, mated 4-day male    47 accessory gland, mated 4-day male    20 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (124) central nervous system, larvae L3  (90) central nervous system, pupae P8  (27) head, virgin 1-day female    10 head, virgin 4-day female    12 head, virgin 20-day female    14 head, mated 1-day female    8 head, mated 4-day female    20 head, mated 20-day female    12 head, mated 1-day male    12 head, mated 4-day male    13 head, mated 20-day male    21 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    13 digestive system, larvae L3 wandering  (36) digestive system, 1-day adult  (28) digestive system, 4-day adult  (38) digestive system, 20-day adult  (41) fat body, larvae L3 wandering    8 fat body, white prepupae    23 fat body, pupae P8    23 carcass, larvae L3 wandering  (84) carcass, 1-day adult    17 carcass, 4-day adult  (27) carcass, 20-day adult    24 ovary, virgin 4-day female  (164) ovary, mated 4-day female  (146) testis, mated 4-day male  (47) accessory gland, mated 4-day male    20 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (124) central nervous system, larvae L3    90 central nervous system, pupae P8    27 head, virgin 1-day female    10 head, virgin 4-day female    12 head, virgin 20-day female    14 head, mated 1-day female    8 head, mated 4-day female    20 head, mated 20-day female    12 head, mated 1-day male    12 head, mated 4-day male    13 head, mated 20-day male    21 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    13 digestive system, larvae L3 wandering    36 digestive system, 1-day adult    28 digestive system, 4-day adult    38 digestive system, 20-day adult    41 fat body, larvae L3 wandering    8 fat body, white prepupae    23 fat body, pupae P8    23 carcass, larvae L3 wandering    84 carcass, 1-day adult    17 carcass, 4-day adult    27 carcass, 20-day adult    24 ovary, virgin 4-day female  (164) ovary, mated 4-day female  (146) testis, mated 4-day male    47 accessory gland, mated 4-day male    20 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    124 central nervous system, larvae L3    90 central nervous system, pupae P8    27 head, virgin 1-day female    10 head, virgin 4-day female    12 head, virgin 20-day female    14 head, mated 1-day female    8 head, mated 4-day female    20 head, mated 20-day female    12 head, mated 1-day male    12 head, mated 4-day male    13 head, mated 20-day male    21 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    13 digestive system, larvae L3 wandering    36 digestive system, 1-day adult    28 digestive system, 4-day adult    38 digestive system, 20-day adult    41 fat body, larvae L3 wandering    8 fat body, white prepupae    23 fat body, pupae P8    23 carcass, larvae L3 wandering    84 carcass, 1-day adult    17 carcass, 4-day adult    27 carcass, 20-day adult    24 ovary, virgin 4-day female    164 ovary, mated 4-day female    146 testis, mated 4-day male    47 accessory gland, mated 4-day male    20 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    124 central nervous system, larvae L3    90 central nervous system, pupae P8    27 head, virgin 1-day female    10 head, virgin 4-day female    12 head, virgin 20-day female    14 head, mated 1-day female    8 head, mated 4-day female    20 head, mated 20-day female    12 head, mated 1-day male    12 head, mated 4-day male    13 head, mated 20-day male    21 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    13 digestive system, larvae L3 wandering    36 digestive system, 1-day adult    28 digestive system, 4-day adult    38 digestive system, 20-day adult    41 fat body, larvae L3 wandering    8 fat body, white prepupae    23 fat body, pupae P8    23 carcass, larvae L3 wandering    84 carcass, 1-day adult    17 carcass, 4-day adult    27 carcass, 20-day adult    24 ovary, virgin 4-day female    164 ovary, mated 4-day female    146 testis, mated 4-day male    47 accessory gland, mated 4-day male    20 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (124) central nervous system, larvae L3  (90) central nervous system, pupae P8  27 head, virgin 1-day female    10 head, virgin 4-day female    12 head, virgin 20-day female    14 head, mated 1-day female    8 head, mated 4-day female    20 head, mated 20-day female    12 head, mated 1-day male    12 head, mated 4-day male    13 head, mated 20-day male    21 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    13 digestive system, larvae L3 wandering  (36) digestive system, 1-day adult  28 digestive system, 4-day adult  (38) digestive system, 20-day adult  (41) fat body, larvae L3 wandering    8 fat body, white prepupae    23 fat body, pupae P8    23 carcass, larvae L3 wandering  (84) carcass, 1-day adult    17 carcass, 4-day adult  27 carcass, 20-day adult    24 ovary, virgin 4-day female  (164) ovary, mated 4-day female  (146) testis, mated 4-day male  (47) accessory gland, mated 4-day male    20 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering  124 central nervous system, larvae L3    90 central nervous system, pupae P8    27 head, virgin 1-day female    10 head, virgin 4-day female    12 head, virgin 20-day female    14 head, mated 1-day female    8 head, mated 4-day female    20 head, mated 20-day female    12 head, mated 1-day male    12 head, mated 4-day male    13 head, mated 20-day male    21 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    13 digestive system, larvae L3 wandering    36 digestive system, 1-day adult    28 digestive system, 4-day adult    38 digestive system, 20-day adult    41 fat body, larvae L3 wandering    8 fat body, white prepupae    23 fat body, pupae P8    23 carcass, larvae L3 wandering    84 carcass, 1-day adult    17 carcass, 4-day adult    27 carcass, 20-day adult    24 ovary, virgin 4-day female  (164) ovary, mated 4-day female  (146) testis, mated 4-day male    47 accessory gland, mated 4-day male    20 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    124 central nervous system, larvae L3    90 central nervous system, pupae P8    27 head, virgin 1-day female    10 head, virgin 4-day female    12 head, virgin 20-day female    14 head, mated 1-day female    8 head, mated 4-day female    20 head, mated 20-day female    12 head, mated 1-day male    12 head, mated 4-day male    13 head, mated 20-day male    21 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    13 digestive system, larvae L3 wandering    36 digestive system, 1-day adult    28 digestive system, 4-day adult    38 digestive system, 20-day adult    41 fat body, larvae L3 wandering    8 fat body, white prepupae    23 fat body, pupae P8    23 carcass, larvae L3 wandering    84 carcass, 1-day adult    17 carcass, 4-day adult    27 carcass, 20-day adult    24 ovary, virgin 4-day female    164 ovary, mated 4-day female    146 testis, mated 4-day male    47 accessory gland, mated 4-day male    20 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderately high expression. Peak expression observed within 00-12 hour embryonic stages, during early larval stages, in adult female stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    254 embryo 02-04hr    82 embryo 04-06hr    59 embryo 06-08hr    109 embryo 08-10hr    113 embryo 10-12hr    165 embryo 12-14hr    114 embryo 14-16hr    114 embryo 16-18hr    80 embryo 18-20hr    60 embryo 20-22hr    63 embryo 22-24hr    54 larva L1    180 larva L2    160 larva L3 12hr old    108 larva L3 puffstage 1-2    59 larva L3 puffstage 3-6    85 larva L3 puffstage 7-9    94 white prepupae new    97 white prepupae 12hr    84 white prepupae 24hr    99 pupae 2d postWPP    75 pupae 3d postWPP    57 pupae 4d postWPP    51 adult male 01day    31 adult male 05day    36 adult male 30day    40 adult female 01day    166 adult female 05day    225 adult female 30day    229 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (254) embryo 02-04hr  (82) embryo 04-06hr  (59) embryo 06-08hr  (109) embryo 08-10hr  (113) embryo 10-12hr  (165) embryo 12-14hr  (114) embryo 14-16hr  (114) embryo 16-18hr  (80) embryo 18-20hr  (60) embryo 20-22hr  (63) embryo 22-24hr  (54) larva L1  (180) larva L2  (160) larva L3 12hr old  (108) larva L3 puffstage 1-2  (59) larva L3 puffstage 3-6  (85) larva L3 puffstage 7-9  (94) white prepupae new  (97) white prepupae 12hr  (84) white prepupae 24hr  (99) pupae 2d postWPP  (75) pupae 3d postWPP  (57) pupae 4d postWPP  (51) adult male 01day  (31) adult male 05day  (36) adult male 30day  (40) adult female 01day  (166) adult female 05day  (225) adult female 30day  (229) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  (254) embryo 02-04hr    82 embryo 04-06hr    59 embryo 06-08hr  (109) embryo 08-10hr  (113) embryo 10-12hr  (165) embryo 12-14hr  (114) embryo 14-16hr  (114) embryo 16-18hr    80 embryo 18-20hr    60 embryo 20-22hr    63 embryo 22-24hr    54 larva L1  (180) larva L2  (160) larva L3 12hr old  (108) larva L3 puffstage 1-2    59 larva L3 puffstage 3-6    85 larva L3 puffstage 7-9    94 white prepupae new    97 white prepupae 12hr    84 white prepupae 24hr    99 pupae 2d postWPP    75 pupae 3d postWPP    57 pupae 4d postWPP    51 adult male 01day    31 adult male 05day    36 adult male 30day    40 adult female 01day  (166) adult female 05day  (225) adult female 30day  (229) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    254 embryo 02-04hr    82 embryo 04-06hr    59 embryo 06-08hr    109 embryo 08-10hr    113 embryo 10-12hr    165 embryo 12-14hr    114 embryo 14-16hr    114 embryo 16-18hr    80 embryo 18-20hr    60 embryo 20-22hr    63 embryo 22-24hr    54 larva L1    180 larva L2    160 larva L3 12hr old    108 larva L3 puffstage 1-2    59 larva L3 puffstage 3-6    85 larva L3 puffstage 7-9    94 white prepupae new    97 white prepupae 12hr    84 white prepupae 24hr    99 pupae 2d postWPP    75 pupae 3d postWPP    57 pupae 4d postWPP    51 adult male 01day    31 adult male 05day    36 adult male 30day    40 adult female 01day    166 adult female 05day    225 adult female 30day    229 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    254 embryo 02-04hr    82 embryo 04-06hr    59 embryo 06-08hr    109 embryo 08-10hr    113 embryo 10-12hr    165 embryo 12-14hr    114 embryo 14-16hr    114 embryo 16-18hr    80 embryo 18-20hr    60 embryo 20-22hr    63 embryo 22-24hr    54 larva L1    180 larva L2    160 larva L3 12hr old    108 larva L3 puffstage 1-2    59 larva L3 puffstage 3-6    85 larva L3 puffstage 7-9    94 white prepupae new    97 white prepupae 12hr    84 white prepupae 24hr    99 pupae 2d postWPP    75 pupae 3d postWPP    57 pupae 4d postWPP    51 adult male 01day    31 adult male 05day    36 adult male 30day    40 adult female 01day    166 adult female 05day    225 adult female 30day    229 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (254) embryo 02-04hr  (82) embryo 04-06hr  (59) embryo 06-08hr  (109) embryo 08-10hr  (113) embryo 10-12hr  (165) embryo 12-14hr  (114) embryo 14-16hr  (114) embryo 16-18hr  (80) embryo 18-20hr  (60) embryo 20-22hr  (63) embryo 22-24hr  (54) larva L1  (180) larva L2  (160) larva L3 12hr old  (108) larva L3 puffstage 1-2  (59) larva L3 puffstage 3-6  (85) larva L3 puffstage 7-9  (94) white prepupae new  (97) white prepupae 12hr  (84) white prepupae 24hr  (99) pupae 2d postWPP  (75) pupae 3d postWPP  (57) pupae 4d postWPP  (51) adult male 01day  31 adult male 05day  (36) adult male 30day  (40) adult female 01day  (166) adult female 05day  (225) adult female 30day  (229) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  (254) embryo 02-04hr    82 embryo 04-06hr    59 embryo 06-08hr  109 embryo 08-10hr  113 embryo 10-12hr  (165) embryo 12-14hr  114 embryo 14-16hr  114 embryo 16-18hr    80 embryo 18-20hr    60 embryo 20-22hr    63 embryo 22-24hr    54 larva L1  (180) larva L2  (160) larva L3 12hr old  108 larva L3 puffstage 1-2    59 larva L3 puffstage 3-6    85 larva L3 puffstage 7-9    94 white prepupae new    97 white prepupae 12hr    84 white prepupae 24hr    99 pupae 2d postWPP    75 pupae 3d postWPP    57 pupae 4d postWPP    51 adult male 01day    31 adult male 05day    36 adult male 30day    40 adult female 01day  (166) adult female 05day  (225) adult female 30day  (229) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    254 embryo 02-04hr    82 embryo 04-06hr    59 embryo 06-08hr    109 embryo 08-10hr    113 embryo 10-12hr    165 embryo 12-14hr    114 embryo 14-16hr    114 embryo 16-18hr    80 embryo 18-20hr    60 embryo 20-22hr    63 embryo 22-24hr    54 larva L1    180 larva L2    160 larva L3 12hr old    108 larva L3 puffstage 1-2    59 larva L3 puffstage 3-6    85 larva L3 puffstage 7-9    94 white prepupae new    97 white prepupae 12hr    84 white prepupae 24hr    99 pupae 2d postWPP    75 pupae 3d postWPP    57 pupae 4d postWPP    51 adult male 01day    31 adult male 05day    36 adult male 30day    40 adult female 01day    166 adult female 05day    225 adult female 30day    229 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    244 Schneider line 2 Sg4    316 embryonic 1182-4H    160 embryonic GM2    122 embryonic Kc167    87 embryonic S1    149 embryonic S3    186 leg disc CME L1    334 wing disc CME-W2    140 wing disc ML-DmD8    151 wing disc ML-DmD9    145 wing disc ML-DmD16-c3    126 wing disc ML-DmD21    219 wing disc ML-DmD32    114 haltere disc ML-DmD17-c3    160 eye-antennal disc ML-DmD11    166 antennal disc ML-DmD20-c5    150 mixed discs ML-DmD4-c1    200 CNS ML-DmBG1-c1    179 CNS ML-DmBG2-c2    132 tumorous blood cells mbn2    122 ovary fGS/OSS    130 ovary OSC    125 ovary OSS    88 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (244) Schneider line 2 Sg4  (316) embryonic 1182-4H  (160) embryonic GM2  (122) embryonic Kc167  (87) embryonic S1  (149) embryonic S3  (186) leg disc CME L1  (334) wing disc CME-W2  (140) wing disc ML-DmD8  (151) wing disc ML-DmD9  (145) wing disc ML-DmD16-c3  (126) wing disc ML-DmD21  (219) wing disc ML-DmD32  (114) haltere disc ML-DmD17-c3  (160) eye-antennal disc ML-DmD11  (166) antennal disc ML-DmD20-c5  (150) mixed discs ML-DmD4-c1  (200) CNS ML-DmBG1-c1  (179) CNS ML-DmBG2-c2  (132) tumorous blood cells mbn2  (122) ovary fGS/OSS  (130) ovary OSC  (125) ovary OSS  (88) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+  (244) Schneider line 2 Sg4  (316) embryonic 1182-4H  (160) embryonic GM2  (122) embryonic Kc167    87 embryonic S1  (149) embryonic S3  (186) leg disc CME L1  (334) wing disc CME-W2  (140) wing disc ML-DmD8  (151) wing disc ML-DmD9  (145) wing disc ML-DmD16-c3  (126) wing disc ML-DmD21  (219) wing disc ML-DmD32  (114) haltere disc ML-DmD17-c3  (160) eye-antennal disc ML-DmD11  (166) antennal disc ML-DmD20-c5  (150) mixed discs ML-DmD4-c1  (200) CNS ML-DmBG1-c1  (179) CNS ML-DmBG2-c2  (132) tumorous blood cells mbn2  (122) ovary fGS/OSS  (130) ovary OSC  (125) ovary OSS    88 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    244 Schneider line 2 Sg4    316 embryonic 1182-4H    160 embryonic GM2    122 embryonic Kc167    87 embryonic S1    149 embryonic S3    186 leg disc CME L1    334 wing disc CME-W2    140 wing disc ML-DmD8    151 wing disc ML-DmD9    145 wing disc ML-DmD16-c3    126 wing disc ML-DmD21    219 wing disc ML-DmD32    114 haltere disc ML-DmD17-c3    160 eye-antennal disc ML-DmD11    166 antennal disc ML-DmD20-c5    150 mixed discs ML-DmD4-c1    200 CNS ML-DmBG1-c1    179 CNS ML-DmBG2-c2    132 tumorous blood cells mbn2    122 ovary fGS/OSS    130 ovary OSC    125 ovary OSS    88 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    244 Schneider line 2 Sg4    316 embryonic 1182-4H    160 embryonic GM2    122 embryonic Kc167    87 embryonic S1    149 embryonic S3    186 leg disc CME L1    334 wing disc CME-W2    140 wing disc ML-DmD8    151 wing disc ML-DmD9    145 wing disc ML-DmD16-c3    126 wing disc ML-DmD21    219 wing disc ML-DmD32    114 haltere disc ML-DmD17-c3    160 eye-antennal disc ML-DmD11    166 antennal disc ML-DmD20-c5    150 mixed discs ML-DmD4-c1    200 CNS ML-DmBG1-c1    179 CNS ML-DmBG2-c2    132 tumorous blood cells mbn2    122 ovary fGS/OSS    130 ovary OSC    125 ovary OSS    88 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (244) Schneider line 2 Sg4  (316) embryonic 1182-4H  (160) embryonic GM2  (122) embryonic Kc167  (87) embryonic S1  (149) embryonic S3  (186) leg disc CME L1  (334) wing disc CME-W2  (140) wing disc ML-DmD8  (151) wing disc ML-DmD9  (145) wing disc ML-DmD16-c3  (126) wing disc ML-DmD21  (219) wing disc ML-DmD32  (114) haltere disc ML-DmD17-c3  (160) eye-antennal disc ML-DmD11  (166) antennal disc ML-DmD20-c5  (150) mixed discs ML-DmD4-c1  (200) CNS ML-DmBG1-c1  (179) CNS ML-DmBG2-c2  (132) tumorous blood cells mbn2  (122) ovary fGS/OSS  (130) ovary OSC  (125) ovary OSS  (88) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+  (244) Schneider line 2 Sg4  (316) embryonic 1182-4H  (160) embryonic GM2  122 embryonic Kc167    87 embryonic S1  (149) embryonic S3  (186) leg disc CME L1  (334) wing disc CME-W2  140 wing disc ML-DmD8  (151) wing disc ML-DmD9  (145) wing disc ML-DmD16-c3  126 wing disc ML-DmD21  (219) wing disc ML-DmD32  114 haltere disc ML-DmD17-c3  (160) eye-antennal disc ML-DmD11  (166) antennal disc ML-DmD20-c5  (150) mixed discs ML-DmD4-c1  (200) CNS ML-DmBG1-c1  (179) CNS ML-DmBG2-c2  132 tumorous blood cells mbn2  122 ovary fGS/OSS  130 ovary OSC  125 ovary OSS    88 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    244 Schneider line 2 Sg4    316 embryonic 1182-4H    160 embryonic GM2    122 embryonic Kc167    87 embryonic S1    149 embryonic S3    186 leg disc CME L1    334 wing disc CME-W2    140 wing disc ML-DmD8    151 wing disc ML-DmD9    145 wing disc ML-DmD16-c3    126 wing disc ML-DmD21    219 wing disc ML-DmD32    114 haltere disc ML-DmD17-c3    160 eye-antennal disc ML-DmD11    166 antennal disc ML-DmD20-c5    150 mixed discs ML-DmD4-c1    200 CNS ML-DmBG1-c1    179 CNS ML-DmBG2-c2    132 tumorous blood cells mbn2    122 ovary fGS/OSS    130 ovary OSC    125 ovary OSS    88 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    58 cold shock, 4-day adult    43 heat shock, 4-day adult    84 Cadmium 50 mM 6 hrs, larvae L3    49 Cadmium 50 mM 12 hrs, larvae L3    39 Cadmium 50 mM 48 hrs, 4-day adult    71 Cadmium 100 mM 48 hrs, 4-day adult    99 Copper 0.5 mM 12 hrs, larvae L3    39 Copper 15 mM 48 hrs, 4-day adult    67 Zinc 5 mM 12 hrs, larvae L3    29 Zinc 4.5 mM 48 hrs, 4-day adult    39 Ethanol 2.5% 3 hrs, larvae L3    141 Ethanol 5% 3 hrs, larvae L3    43 Ethanol 10% 3 hrs, larvae L3    56 Caffeine 1.5 mg/ml 4 hrs, larvae L3    24 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    93 Caffeine 25 mg/ml 48 hrs, 4-day adult    45 Paraquat 5 mM 48 hrs, 4-day adult    90 Paraquat 10 mM 48 hrs, 4-day adult    94 Rotenone 2 μg 12 hrs, larvae L3    66 Rotenone 8 μg 12 hrs, larvae L3    74 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (58) cold shock, 4-day adult  (43) heat shock, 4-day adult  (84) Cadmium 50 mM 6 hrs, larvae L3  (49) Cadmium 50 mM 12 hrs, larvae L3  (39) Cadmium 50 mM 48 hrs, 4-day adult  (71) Cadmium 100 mM 48 hrs, 4-day adult  (99) Copper 0.5 mM 12 hrs, larvae L3  (39) Copper 15 mM 48 hrs, 4-day adult  (67) Zinc 5 mM 12 hrs, larvae L3  (29) Zinc 4.5 mM 48 hrs, 4-day adult  (39) Ethanol 2.5% 3 hrs, larvae L3  (141) Ethanol 5% 3 hrs, larvae L3  (43) Ethanol 10% 3 hrs, larvae L3  (56) Caffeine 1.5 mg/ml 4 hrs, larvae L3    24 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (93) Caffeine 25 mg/ml 48 hrs, 4-day adult  (45) Paraquat 5 mM 48 hrs, 4-day adult  (90) Paraquat 10 mM 48 hrs, 4-day adult  (94) Rotenone 2 μg 12 hrs, larvae L3  (66) Rotenone 8 μg 12 hrs, larvae L3  (74) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    58 cold shock, 4-day adult    43 heat shock, 4-day adult    84 Cadmium 50 mM 6 hrs, larvae L3    49 Cadmium 50 mM 12 hrs, larvae L3    39 Cadmium 50 mM 48 hrs, 4-day adult    71 Cadmium 100 mM 48 hrs, 4-day adult    99 Copper 0.5 mM 12 hrs, larvae L3    39 Copper 15 mM 48 hrs, 4-day adult    67 Zinc 5 mM 12 hrs, larvae L3    29 Zinc 4.5 mM 48 hrs, 4-day adult    39 Ethanol 2.5% 3 hrs, larvae L3  (141) Ethanol 5% 3 hrs, larvae L3    43 Ethanol 10% 3 hrs, larvae L3    56 Caffeine 1.5 mg/ml 4 hrs, larvae L3    24 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    93 Caffeine 25 mg/ml 48 hrs, 4-day adult    45 Paraquat 5 mM 48 hrs, 4-day adult    90 Paraquat 10 mM 48 hrs, 4-day adult    94 Rotenone 2 μg 12 hrs, larvae L3    66 Rotenone 8 μg 12 hrs, larvae L3    74 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    58 cold shock, 4-day adult    43 heat shock, 4-day adult    84 Cadmium 50 mM 6 hrs, larvae L3    49 Cadmium 50 mM 12 hrs, larvae L3    39 Cadmium 50 mM 48 hrs, 4-day adult    71 Cadmium 100 mM 48 hrs, 4-day adult    99 Copper 0.5 mM 12 hrs, larvae L3    39 Copper 15 mM 48 hrs, 4-day adult    67 Zinc 5 mM 12 hrs, larvae L3    29 Zinc 4.5 mM 48 hrs, 4-day adult    39 Ethanol 2.5% 3 hrs, larvae L3    141 Ethanol 5% 3 hrs, larvae L3    43 Ethanol 10% 3 hrs, larvae L3    56 Caffeine 1.5 mg/ml 4 hrs, larvae L3    24 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    93 Caffeine 25 mg/ml 48 hrs, 4-day adult    45 Paraquat 5 mM 48 hrs, 4-day adult    90 Paraquat 10 mM 48 hrs, 4-day adult    94 Rotenone 2 μg 12 hrs, larvae L3    66 Rotenone 8 μg 12 hrs, larvae L3    74 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    58 cold shock, 4-day adult    43 heat shock, 4-day adult    84 Cadmium 50 mM 6 hrs, larvae L3    49 Cadmium 50 mM 12 hrs, larvae L3    39 Cadmium 50 mM 48 hrs, 4-day adult    71 Cadmium 100 mM 48 hrs, 4-day adult    99 Copper 0.5 mM 12 hrs, larvae L3    39 Copper 15 mM 48 hrs, 4-day adult    67 Zinc 5 mM 12 hrs, larvae L3    29 Zinc 4.5 mM 48 hrs, 4-day adult    39 Ethanol 2.5% 3 hrs, larvae L3    141 Ethanol 5% 3 hrs, larvae L3    43 Ethanol 10% 3 hrs, larvae L3    56 Caffeine 1.5 mg/ml 4 hrs, larvae L3    24 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    93 Caffeine 25 mg/ml 48 hrs, 4-day adult    45 Paraquat 5 mM 48 hrs, 4-day adult    90 Paraquat 10 mM 48 hrs, 4-day adult    94 Rotenone 2 μg 12 hrs, larvae L3    66 Rotenone 8 μg 12 hrs, larvae L3    74 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (58) cold shock, 4-day adult  (43) heat shock, 4-day adult  (84) Cadmium 50 mM 6 hrs, larvae L3  (49) Cadmium 50 mM 12 hrs, larvae L3  (39) Cadmium 50 mM 48 hrs, 4-day adult  (71) Cadmium 100 mM 48 hrs, 4-day adult  (99) Copper 0.5 mM 12 hrs, larvae L3  (39) Copper 15 mM 48 hrs, 4-day adult  (67) Zinc 5 mM 12 hrs, larvae L3  29 Zinc 4.5 mM 48 hrs, 4-day adult  (39) Ethanol 2.5% 3 hrs, larvae L3  (141) Ethanol 5% 3 hrs, larvae L3  (43) Ethanol 10% 3 hrs, larvae L3  (56) Caffeine 1.5 mg/ml 4 hrs, larvae L3    24 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (93) Caffeine 25 mg/ml 48 hrs, 4-day adult  (45) Paraquat 5 mM 48 hrs, 4-day adult  (90) Paraquat 10 mM 48 hrs, 4-day adult  (94) Rotenone 2 μg 12 hrs, larvae L3  (66) Rotenone 8 μg 12 hrs, larvae L3  (74) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    58 cold shock, 4-day adult    43 heat shock, 4-day adult    84 Cadmium 50 mM 6 hrs, larvae L3    49 Cadmium 50 mM 12 hrs, larvae L3    39 Cadmium 50 mM 48 hrs, 4-day adult    71 Cadmium 100 mM 48 hrs, 4-day adult    99 Copper 0.5 mM 12 hrs, larvae L3    39 Copper 15 mM 48 hrs, 4-day adult    67 Zinc 5 mM 12 hrs, larvae L3    29 Zinc 4.5 mM 48 hrs, 4-day adult    39 Ethanol 2.5% 3 hrs, larvae L3  141 Ethanol 5% 3 hrs, larvae L3    43 Ethanol 10% 3 hrs, larvae L3    56 Caffeine 1.5 mg/ml 4 hrs, larvae L3    24 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    93 Caffeine 25 mg/ml 48 hrs, 4-day adult    45 Paraquat 5 mM 48 hrs, 4-day adult    90 Paraquat 10 mM 48 hrs, 4-day adult    94 Rotenone 2 μg 12 hrs, larvae L3    66 Rotenone 8 μg 12 hrs, larvae L3    74 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    58 cold shock, 4-day adult    43 heat shock, 4-day adult    84 Cadmium 50 mM 6 hrs, larvae L3    49 Cadmium 50 mM 12 hrs, larvae L3    39 Cadmium 50 mM 48 hrs, 4-day adult    71 Cadmium 100 mM 48 hrs, 4-day adult    99 Copper 0.5 mM 12 hrs, larvae L3    39 Copper 15 mM 48 hrs, 4-day adult    67 Zinc 5 mM 12 hrs, larvae L3    29 Zinc 4.5 mM 48 hrs, 4-day adult    39 Ethanol 2.5% 3 hrs, larvae L3    141 Ethanol 5% 3 hrs, larvae L3    43 Ethanol 10% 3 hrs, larvae L3    56 Caffeine 1.5 mg/ml 4 hrs, larvae L3    24 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    93 Caffeine 25 mg/ml 48 hrs, 4-day adult    45 Paraquat 5 mM 48 hrs, 4-day adult    90 Paraquat 10 mM 48 hrs, 4-day adult    94 Rotenone 2 μg 12 hrs, larvae L3    66 Rotenone 8 μg 12 hrs, larvae L3    74 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_03 mE1_20_mRNA_expression_cluster_02
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0037632 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG8351-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal Tcp-1ηCA07228 Tcp-1ηGD13899 lethal, with Scer\GAL4pnr-MD237 Tcp-1ηGD13899 Other Phenotypes Allele neuroanatomy defective | larval stage Tcp-1ηGD13899 Phenotype manifest in Allele embryonic/larval neuroblast | larval stage Tcp-1ηGD13899 ganglion mother cell | larval stage Tcp-1ηGD13899
Classical Alleles ( 8 )
For All Classical Alleles Show
Allele of Tcp-1η Class Mutagen Stocks Known lesion Tcp-1ηc02482 piggyBac transposase 1 -- Tcp-1ηGS5233 1 -- Tcp-1ηKG01477 P-element activity 1 -- Tcp-1ηKG09501 P-element activity 1 -- Tcp-1ηMB09573 1 -- Tcp-1ηCA07228 P-element activity 0 Yes Tcp-1ηCPTI002629 piggyBac transposase 0 Yes Tcp-1ηF463.1 Delta2-3 0 Yes
Alleles Carried on Transgenic Constructs ( 4 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Tcp-1η Class Mutagen Stocks Known lesion Tcp-1ηGD13899 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Tcp-1ηHMS01281 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Tcp-1ηKK101540 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Tcp-1ηNIG.8351R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3R)Exel6150 (Ryder, 2004.4.26) Df(3R)Exel8143 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data
Insertions
	Type of insertions Name Expression data miscellaneous insertions P{PTT-GA}Tcp-1ηCA07228 NA P{SUPor-P}Tcp-1ηKG01477 NA P{SUPor-P}Tcp-1ηKG09501 NA PBac{769.FSVS-1}Tcp-1ηCPTI002629 NA PBac{PB}Tcp-1ηc02482 NA insertion of mobile activating element P{GSV2}Tcp-1ηGS5233 NA P{Mae-UAS.6.11}Tcp-1ηF463.1 NA insertion of enhancer trap binary system Mi{ET1}Tcp-1ηMB09573 No
Gene Ontology: Function, Process & Cellular Component ( 9 unique terms )
Terms Based on Experimental Evidence ( 4 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
cytoplasmic microtubule organization inferred from mutant phenotype (Hughes et al., 2008) mitotic spindle organization inferred from mutant phenotype (Goshima et al., 2007, Hughes et al., 2008) neurogenesis inferred from mutant phenotype (Neumüller et al., 2011)
Cellular Component
CV term Evidence References
microtubule associated complex inferred from direct assay (Hughes et al., 2008)
Terms Based on Predictions or Assertions ( 5 terms )
Molecular Function
CV term Evidence References
ATPase activity, coupled inferred from sequence or structural similarity with UniProtKB:Q99832 (FlyBase, 1992-) ATP binding inferred from electronic annotation with InterPro:IPR002194, InterPro:IPR002423, InterPro:IPR012720 (FlyBase Curators et al., 2004-) unfolded protein binding inferred from electronic annotation with InterPro:IPR002194, InterPro:IPR012720 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
protein folding inferred from sequence or structural similarity with UniProtKB:Q99832 (FlyBase, 1992-)
Cellular Component
CV term Evidence References
chaperonin-containing T-complex inferred from sequence or structural similarity with UniProtKB:Q99832 (FlyBase, 1992-)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
Tcp-1η - 5-HT7 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tcp-1η - Aats-asn anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tcp-1η - Aats-his anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tcp-1η - Ada anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tcp-1η - Arp1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tcp-1η - Ate1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tcp-1η - Bx anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tcp-1η - CG10175 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tcp-1η - CG10425 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tcp-1η - CG10859 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tcp-1η - CG10934 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tcp-1η - CG1105 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tcp-1η - CG1109 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tcp-1η - CG11279 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tcp-1η - CG11534 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tcp-1η - CG11697 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tcp-1η - CG11876 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tcp-1η - CG12084 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tcp-1η - CG12262 experimental knowledge based (Guruharsha et al., 2011) Tcp-1η - CG12289 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tcp-1η - CG12333 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tcp-1η - CG1246 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tcp-1η - CG1265 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tcp-1η - CG14024 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tcp-1η - CG1444 experimental knowledge based (Guruharsha et al., 2011) Tcp-1η - CG14722 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tcp-1η - CG15084 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tcp-1η - CG15097 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tcp-1η - CG15236 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tcp-1η - CG15309 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tcp-1η - CG15625 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tcp-1η - CG15643 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tcp-1η - CG15800 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tcp-1η - CG17029 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tcp-1η - CG17242 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tcp-1η - CG17259 experimental knowledge based (Guruharsha et al., 2011) Tcp-1η - CG17337 experimental knowledge based (Guruharsha et al., 2011) Tcp-1η - CG1814 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tcp-1η - CG2064 experimental knowledge based (Guruharsha et al., 2011) Tcp-1η - CG2183 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tcp-1η - CG2789 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tcp-1η - CG2812 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tcp-1η - CG2931 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tcp-1η - CG30184 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tcp-1η - CG3091 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tcp-1η - CG31522 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tcp-1η - CG31523 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tcp-1η - CG31802 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tcp-1η - CG31961 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tcp-1η - CG3303 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tcp-1η - CG3313 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tcp-1η - CG33145 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tcp-1η - CG33303 experimental knowledge based (Guruharsha et al., 2011) Tcp-1η - CG33523 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tcp-1η - CG3523 experimental knowledge based (Guruharsha et al., 2011) Tcp-1η - CG3570 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tcp-1η - CG40160 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tcp-1η - CG4169 experimental knowledge based (Guruharsha et al., 2011) Tcp-1η - CG4511 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tcp-1η - CG4764 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tcp-1η - CG4766 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tcp-1η - CG5027 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tcp-1η - CG5525 experimental knowledge based (Guruharsha et al., 2011) Tcp-1η - CG5623 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tcp-1η - CG5646 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tcp-1η - CG5805 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tcp-1η - CG5961 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tcp-1η - CG6321 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tcp-1η - CG7033 experimental knowledge based (Guruharsha et al., 2011) Tcp-1η - CG7197 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tcp-1η - CG7275 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tcp-1η - CG7288 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tcp-1η - CG7609 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tcp-1η - CG7650 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tcp-1η - CG7655 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tcp-1η - CG7881 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tcp-1η - CG8004 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tcp-1η - CG8026 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tcp-1η - CG8078 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tcp-1η - CG8258 experimental knowledge based, anti tag coimmunoprecipitation, peptide massfingerprinting (Guruharsha et al., 2011, Mintseris et al., 2009.11.23) Tcp-1η - CG8300 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tcp-1η - CG8680 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tcp-1η - CG9062 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tcp-1η - CG9231 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tcp-1η - CG9536 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tcp-1η - CG9547 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tcp-1η - CG9596 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tcp-1η - CG9945 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tcp-1η - CR18854 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tcp-1η - CSN4 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tcp-1η - Cct5 anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based (Mintseris et al., 2009.11.23, Guruharsha et al., 2011) Tcp-1η - Cctγ experimental knowledge based (Guruharsha et al., 2011) Tcp-1η - Cdc23 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tcp-1η - Chc experimental knowledge based (Guruharsha et al., 2011) Tcp-1η - CkIIβ anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tcp-1η - Ctr1B anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tcp-1η - Cyp12d1-p experimental knowledge based (Guruharsha et al., 2011) Tcp-1η - Cyp4d2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tcp-1η - Cyp6a22 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tcp-1η - Cyp9b2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tcp-1η - Dh44-R2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tcp-1η - Ent2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tcp-1η - Fatp anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tcp-1η - Fim experimental knowledge based (Guruharsha et al., 2011) Tcp-1η - Fmo-2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tcp-1η - Gmd anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tcp-1η - Gp93 experimental knowledge based (Guruharsha et al., 2011) Tcp-1η - Gyk anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tcp-1η - Gαo anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tcp-1η - HPS1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tcp-1η - Hdac3 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tcp-1η - Kap-α3 experimental knowledge based (Guruharsha et al., 2011) Tcp-1η - Karyβ3 experimental knowledge based (Guruharsha et al., 2011) Tcp-1η - Lis-1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tcp-1η - Lst8 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tcp-1η - M6 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tcp-1η - MESK2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tcp-1η - MFS3 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tcp-1η - MRP experimental knowledge based (Guruharsha et al., 2011) Tcp-1η - Mec2 experimental knowledge based (Guruharsha et al., 2011) Tcp-1η - Mpcp experimental knowledge based (Guruharsha et al., 2011) Tcp-1η - Mtr3 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tcp-1η - ND42 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tcp-1η - Ndfip anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tcp-1η - Nle anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tcp-1η - Odc1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tcp-1η - Ost48 experimental knowledge based (Guruharsha et al., 2011) Tcp-1η - OstΔ experimental knowledge based (Guruharsha et al., 2011) Tcp-1η - Past1 experimental knowledge based (Guruharsha et al., 2011) Tcp-1η - Pp2A-29B experimental knowledge based (Guruharsha et al., 2011) Tcp-1η - Pp2B-14D anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tcp-1η - Rcd6 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tcp-1η - Rheb anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tcp-1η - Rpd3 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tcp-1η - Rpp30 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tcp-1η - Rpt1 experimental knowledge based (Guruharsha et al., 2011) Tcp-1η - SP2637 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tcp-1η - Sac1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tcp-1η - Shawn anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tcp-1η - Snap anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tcp-1η - Socs44A anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tcp-1η - Sucb experimental knowledge based (Guruharsha et al., 2011) Tcp-1η - Syb anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tcp-1η - Syx17 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tcp-1η - T-cp1 experimental knowledge based (Guruharsha et al., 2011) Tcp-1η - Tango4 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tcp-1η - Tap42 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tcp-1η - Taspase1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tcp-1η - Tcp-1ζ anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based (Mintseris et al., 2009.11.23, Guruharsha et al., 2011) Tcp-1η - TfIIEα anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tcp-1η - Tg anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tcp-1η - Vap-33-1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tcp-1η - Vha68-2 experimental knowledge based (Guruharsha et al., 2011) Tcp-1η - Wsck anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tcp-1η - atms anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tcp-1η - aur anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tcp-1η - bsh anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tcp-1η - bsk anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tcp-1η - bys anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tcp-1η - coro anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tcp-1η - dpr5 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tcp-1η - fabp anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tcp-1η - fax experimental knowledge based (Guruharsha et al., 2011) Tcp-1η - flw anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tcp-1η - frc anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tcp-1η - fzr2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tcp-1η - fzy anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tcp-1η - grk anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tcp-1η - gro anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tcp-1η - l(1)G0156 experimental knowledge based (Guruharsha et al., 2011) Tcp-1η - l(2)08717 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tcp-1η - l(2)dtl anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tcp-1η - ldbr anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tcp-1η - mio anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tcp-1η - mts anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tcp-1η - nclb anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tcp-1η - nes anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tcp-1η - ninaA anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tcp-1η - out anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tcp-1η - rho anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tcp-1η - rux anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tcp-1η - shd anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tcp-1η - shrb anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tcp-1η - slmb anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tcp-1η - viaf experimental knowledge based, anti tag coimmunoprecipitation, peptide massfingerprinting (Guruharsha et al., 2011, Mintseris et al., 2009.11.23) Tcp-1η - wal experimental knowledge based (Guruharsha et al., 2011) Tcp-1η - wcd anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tcp-1η - wds anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tcp-1η - zpg anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tcp-1η - βTub85D anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tcp-1η - γTub23C anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Tcp-1η allele Gene References unspecified Nsf2 (Laviolette et al., 2005) os (Mukherjee et al., 2006)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 66226 DroID - A comprehensive database of gene and protein interactions. • FBgn0037632 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 41054
Orthologs
OrthoDB Orthologs (39) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6FTWK8 Dipteran inclusive ortholog search EOG612MDR Insect inclusive ortholog search EOG6NZSPJ Arthropod inclusive ortholog search EOG6V9S5X Metazoa inclusive ortholog search EOG6ZH25M
Orthologs in Drosophila Species (EOG6FTWK8)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\Tcp-1η     Drosophila simulans   Dsim\GD18576 Y   Drosophila sechellia   Dsec\GM23766 Y   Drosophila erecta   Dere\GG13138 Y   Drosophila yakuba   Dyak\GE25909 Y   Drosophila ananassae   Dana\GF18192 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA21011 Y   Drosophila persimilis   Dper\GL12486 Y   Drosophila willistoni   Dwil\GK11257 Y   Drosophila virilis   Dvir\GJ23495 Y   Drosophila mojavensis   Dmoj\GI23651 Y   Drosophila grimshawi   Dgri\GH18252 Y
Orthologs in non-Drosophila Dipterans (EOG612MDR)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL000486   Anopheles gambiae Malaria mosquito  Agam\AGAP002762   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ006040
Orthologs in non-Dipteran Insects (EOG6NZSPJ)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\Tcp-1eta   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG008917   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH22210   Atta cephalotes Leafcutter ant  Acep\ACEP17611   Camponotus floridanus Florida carpenter ant  Cflo\CFLO20050   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL18018   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL17582   Linepithema humile Argentine ant  Lhum\LH15227   Pogonomyrmex barbatus Red harvester ant  Pbar\PB18162   Solenopsis invicta Red fire ant  Sinv\SINV13392   Acyrthosiphon pisum Pea aphid  Apim\ACYPI009151   Bombyx mori Silkmoth  Bmor\BGIBMGA012182   Pediculus humanus Human body louse  Phum\PHUM003760   Tribolium castaneum Red flour beetle  Tcas\TC005004
Orthologs in non-Insect Arthropods (EOG6V9S5X)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\MET2   Ixodes scapularis Deer tick  Isca\ISCW023397
Orthologs in non-Arthropod Metazoa (EOG6ZH25M)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\cct-7   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_004700gn   Danio rerio Zebrafish  Drer\cct7   Xenopus tropicalis Western clawed frog  Xtro\cct7   Gallus gallus Domestic chicken  Ggal\CCT7   Mus musculus House mouse  Mmus\Cct7   Rattus norvegicus Norway rat  Rnor\Cct7   Homo sapiens Human  Hsap\CCT7
Human Orthologs (1)
Gene OMIM HGNC Hsap\CCT7
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD18576 Drosophila sechellia Dsec\GM23766 Drosophila erecta Dere\GG13138 Drosophila yakuba Dyak\GE25909 Drosophila ananassae Dana\GF18192 Drosophila pseudoobscura pseudoobscura Dpse\GA21011 Drosophila persimilis Dper\GL12486 Drosophila willistoni Dwil\GK11257 Drosophila virilis Dvir\GJ23495 Drosophila mojavensis Dmoj\GI23651 Drosophila grimshawi Dgri\GH18252
Stocks & Reagents
Stocks Listed in FlyBase ( 8 )
Bloomington	34931 y1 sc* v1; P{TRiP.HMS01281}attP2 26487 w1118; Mi{ET1}Tcp-1ηMB09573 CG9839MB09573/TM6C, Sb1 13446 y1; P{SUPor-P}Tcp-1ηKG01477 ry506/TM3, Sb1 Ser1 15191 y1; P{SUPor-P}Tcp-1ηKG09501 ry506/TM3, Sb1 Ser1
Harvard	- PBac{PB}Tcp-1ηc02482
Kyoto	200804 w*; P{GSV2}Tcp-1ηGS5233/TM3, Sb1 Ser1
VDRC	v108585 P{KK101540}VIE-260B v28895 w1118; P{GD13899}v28895
Genomic Clones ( 1 )
	BACR02B21 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 67 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD47396
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT08438 AT23059 AT28288 GM02547 GM02761 GM03674 GM04435 GM09025 GM09927 GM17293 GM18027 GM20889 GM22687 GM25063 GM27473 GM29452 HL01996 LD02443 LD06367 LD38071 LP21352 RE12459 RE24471 RE34865 RE37606 RE38588 RE47271 RE53631 RE64734 RE64811 RE65316 RE69856 RE70586 SD03123 SD03201 SD04402 SD08085 SD10791 SD12532 SD15777 SD15902 SD23179 SD26942 SD27269 UT01743
Other clones	98501 AT01370 CK01.86A.G3 EK077005 EK084605 EK125657 EK154437 EK162821 EK168807 EK214856 EK221218 EK222132 EK223628 EK230128 EK259043 EK259535 EK267453 EK268824 FGM103B02 LD10452 UT01667
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0037632 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 41054
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: Tcp-1η CG8351 (Goshima et al., 2007)
Source for database merge of
Additional comments
Other Comments
	RNAi screen using dsRNA made from templates generated with primers directed against this gene in S2 cell results in dim staining of microtubules, and a short monopolar spindle. This phenotype can be observed when the screen is performed with or without Cdc27 dsRNA. (Goshima et al., 2007)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_141578 RefSeq (Proteins) • NP_649835 DDBJ / EMBL / GenBank • AAF54292 AAM52713 AI515529 AW943896 AY122201 BH740736 BZ665688 CZ467981 Entrez Gene - A searchable database of RefSeq genes. • 41054 UniProtKB/TrEMBL • Q9VHL2
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Chaperonin TCP-1, conserved site (IPR002194) Chaperonin Cpn60/TCP-1 (IPR002423) T-complex protein 1, eta subunit (IPR012720) Chaperone tailless complex polypeptide 1 (TCP-1) (IPR017998) TCP-1-like chaperonin intermediate domain (IPR027410) GroEL-like apical domain (IPR027409) GroEL-like equatorial domain (IPR027413)
Linkouts
	BioGRID - A database of protein and genetic interactions • 66226 DroID - A comprehensive database of gene and protein interactions. • FBgn0037632 DRSC - Results from RNAi screens. • FBgn0037632 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0037632 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG8351-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0037632 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 41054 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 41054 modMine - Data generated by the modENCODE project. • FBgn0037632
Synonyms & Secondary IDs ( 6 )
Reported As
Symbol Synonym	Cct7 (Monzo et al., 2010) CG8351 (Liebl et al., 2006, Goshima et al., 2007, Quinones-Coello, 2007, Laviolette et al., 2005, Mukherjee et al., 2006, Buszczak et al., 2007, Hughes et al., 2008, Keleman et al., 2009.8.5, Dorogova et al., 2008, Monzo et al., 2010, Ni et al., 2011.7.19, Cammarato et al., 2011, Japanese National Institute of Genetics, 2012.5.21) Q9VHL2_DROME (Fukuyama et al., 2012) Tcp-1eta (Rees et al., 2011, Kallappagoudar et al., 2010, Neumüller et al., 2011, Fisher et al., 2008) Tcp-1-eta1 (Goshima et al., 2007) Tcp-1η (Monzo et al., 2010)
Name Synonym	CG8351   Tcp-1η
Secondary FlyBase IDs
References ( 41 )
Generate a list of	All references relating to this gene ( 41 )
List References by type	Research paper  ( 16 ) Supplementary material  ( 9 ) Personal communication to FlyBase  ( 12 ) FlyBase analysis  ( 1 ) Stock list  ( 1 ) Curated genome annotation  ( 2 )
Recent research papers ( 5 )
	Fukuyama et al., 2012, J. Proteomics 75(15): 4610--4619 On-bead tryptic proteolysis: An attractive procedure for LC-MS/MS analysis of the Drosophila caspase 8 protein complex during immune response against bacteria. [FBrf0218992] Krauchunas et al., 2012, Dev. Biol. 370(1): 125--134 Protein phosphorylation changes reveal new candidates in the regulation of egg activation and early embryogenesis in D. melanogaster. [FBrf0219342] Pejanovic et al., 2012, PLoS ONE 7(7): e42020 Regulation of Nuclear Factor kappaB (NF-kappaB) Transcriptional Activity via p65 Acetylation by the Chaperonin Containing TCP1 (CCT). [FBrf0219100] Neumüller et al., 2011, Cell Stem Cell 8(5): 580--593 Genome-Wide Analysis of Self-Renewal in Drosophila Neural Stem Cells by Transgenic RNAi. [FBrf0213621] Rees et al., 2011, Mol. Cell. Proteomics 10(6): M110.002386 In Vivo Analysis of Proteomes and Interactomes Using Parallel Affinity Capture (iPAC) Coupled to Mass Spectrometry. [FBrf0213845] Show all research papers ...