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Gene Dmel\CG11975

General Information
Symbol	Dmel\CG11975	Species	D. melanogaster
Name		Annotation symbol	CG11975
Feature type	protein_coding_gene	FlyBase ID	FBgn0037648
Gene Model Status	Current	Stock availability	5 publicly available
Genomic Location
Chromosome (arm)	3R	Recombination map
Cytogenetic map	85C1-85C1	Sequence location	3R:4,818,979..4,820,561 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	This gene is referred to in FlyBase by the symbol Dmel\CG11975 (FBgn0037648). It is a protein_coding_gene from Drosophila melanogaster. Its molecular function is unknown. The biological processes in which it is involved are not known. 3 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: WD40 repeat; WD40 repeat, subgroup; WD40 repeat-like-containing domain; WD40-repeat-containing domain; WD40/YVTN repeat-like-containing domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression. Peak expression observed at stages throughout embryogenesis, during late larval stages, during early pupal stages, in adult female stages. Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult tissues/organs expressed at moderate levels. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male accessory gland, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1632813_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of CG11975. Gene sequence location is 3R:4818979..4820561.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2011_10
FB2012_01	Sequence features BKN20688 BKN46110 HFA14452
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 85C1-85C1   Limits computationally determined from genome sequence between P{lacW}l(3)L4740L4740 and P{EP}D1EP473
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\CG11975 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) CG11975-RA FBtr0081960  NM_141596   1356   340
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein CG11975-PA   FBpp0081440   37.9   340   7.42     NP_649853   AAF54315
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • WD40 repeat (IPR001680) WD40 repeat-like-containing domain (IPR011046) WD40-repeat-containing domain (IPR017986) WD40/YVTN repeat-like-containing domain (IPR015943) WD40 repeat, subgroup (IPR019781)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA540844   AA951707   AE014297 AAF54315   AI513626   AI541675   AI543933   AW943132   BI165276   BI173125   BI173215   BI228134   BI228706   BI367351   BI370987   BI373018   BI564306   BI566004   BI575125   BI575897   BI579467   BI606752   BI632613   BP559764   BP559765   BT021959   CA806157   CA807814   CO154806   CO177591   CO179080   CO189224   CO193291   CO268340   CO270539   CO273124   CO274969   CO275954   CO278538   CO280367   CO281034   CO286165   CO289154   CO296278   CO307582   CO311867   CO314176   CO318085   CO321691   CO330983   CZ475174   CZ475175   DN153914   EC059990   EC060439   EC061658   EC065390   EC076768   EC078201   EC080754   EC083647   EC195891   EC195947   EC197480   EC208390   EC218441   EC219761   EC223219   EC226430   EC231573   EC232769   EC242121   EC250880   EC260603   EC267423   EV593667   GH739191   GH740202   GH740678   GH741444   GH741972   GH742415   GH742485   GH742508   GH742868   GH743378   GH744224   GH745597   GH764271   GH765079   GH765290   GH765679   GH765799   GH766047   GH767133   GH767142   GH767170   GH768253   GH769985   GH779190   GH779203   GH779248   GH779324   GH779337   GH779364   GH779382   GH779466   GH779553   GH779587   GH779590   GH779705   GH779784   GH779805   GH779854   GH779868   GH779880
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9VHJ2
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0037648    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0037648 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression. Peak expression observed at stages throughout embryogenesis, during late larval stages, during early pupal stages, in adult female stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0037648 expression level Developmental Stage   Expression Level embryo 00-02hr    2850 embryo 02-04hr    2940 embryo 04-06hr    2489 embryo 06-08hr    2403 embryo 08-10hr    2370 embryo 10-12hr    2382 embryo 12-14hr    1614 embryo 14-16hr    1564 embryo 16-18hr    1394 embryo 18-20hr    1121 embryo 20-22hr    1933 embryo 22-24hr    1536 larva L1    798 larva L2    737 larva L3 12hr old    640 larva L3 puffstage 1-2    1343 larva L3 puffstage 3-6    2150 larva L3 puffstage 7-9    3110 white prepupae new    3014 white prepupae 12hr    1898 white prepupae 24hr    1500 pupae 2d postWPP    1330 pupae 3d postWPP    895 pupae 4d postWPP    902 adult male 01day    1054 adult male 05day    1294 adult male 30day    1232 adult female 01day    1374 adult female 05day    1659 adult female 30day    1653 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (2850) embryo 02-04hr  (2940) embryo 04-06hr  (2489) embryo 06-08hr  (2403) embryo 08-10hr  (2370) embryo 10-12hr  (2382) embryo 12-14hr  (1614) embryo 14-16hr  (1564) embryo 16-18hr  (1394) embryo 18-20hr  (1121) embryo 20-22hr  (1933) embryo 22-24hr  (1536) larva L1  (798) larva L2  (737) larva L3 12hr old  (640) larva L3 puffstage 1-2  (1343) larva L3 puffstage 3-6  (2150) larva L3 puffstage 7-9  (3110) white prepupae new  (3014) white prepupae 12hr  (1898) white prepupae 24hr  (1500) pupae 2d postWPP  (1330) pupae 3d postWPP  (895) pupae 4d postWPP  (902) adult male 01day  (1054) adult male 05day  (1294) adult male 30day  (1232) adult female 01day  (1374) adult female 05day  (1659) adult female 30day  (1653) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (2850) embryo 02-04hr  (2940) embryo 04-06hr  (2489) embryo 06-08hr  (2403) embryo 08-10hr  (2370) embryo 10-12hr  (2382) embryo 12-14hr  (1614) embryo 14-16hr  (1564) embryo 16-18hr    1394 embryo 18-20hr    1121 embryo 20-22hr  (1933) embryo 22-24hr  (1536) larva L1    798 larva L2    737 larva L3 12hr old    640 larva L3 puffstage 1-2    1343 larva L3 puffstage 3-6  (2150) larva L3 puffstage 7-9  (3110) white prepupae new  (3014) white prepupae 12hr  (1898) white prepupae 24hr  1500 pupae 2d postWPP    1330 pupae 3d postWPP    895 pupae 4d postWPP    902 adult male 01day    1054 adult male 05day    1294 adult male 30day    1232 adult female 01day    1374 adult female 05day  (1659) adult female 30day  (1653) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    2850 embryo 02-04hr    2940 embryo 04-06hr    2489 embryo 06-08hr    2403 embryo 08-10hr    2370 embryo 10-12hr    2382 embryo 12-14hr    1614 embryo 14-16hr    1564 embryo 16-18hr    1394 embryo 18-20hr    1121 embryo 20-22hr    1933 embryo 22-24hr    1536 larva L1    798 larva L2    737 larva L3 12hr old    640 larva L3 puffstage 1-2    1343 larva L3 puffstage 3-6    2150 larva L3 puffstage 7-9    3110 white prepupae new    3014 white prepupae 12hr    1898 white prepupae 24hr    1500 pupae 2d postWPP    1330 pupae 3d postWPP    895 pupae 4d postWPP    902 adult male 01day    1054 adult male 05day    1294 adult male 30day    1232 adult female 01day    1374 adult female 05day    1659 adult female 30day    1653 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    2850 embryo 02-04hr    2940 embryo 04-06hr    2489 embryo 06-08hr    2403 embryo 08-10hr    2370 embryo 10-12hr    2382 embryo 12-14hr    1614 embryo 14-16hr    1564 embryo 16-18hr    1394 embryo 18-20hr    1121 embryo 20-22hr    1933 embryo 22-24hr    1536 larva L1    798 larva L2    737 larva L3 12hr old    640 larva L3 puffstage 1-2    1343 larva L3 puffstage 3-6    2150 larva L3 puffstage 7-9    3110 white prepupae new    3014 white prepupae 12hr    1898 white prepupae 24hr    1500 pupae 2d postWPP    1330 pupae 3d postWPP    895 pupae 4d postWPP    902 adult male 01day    1054 adult male 05day    1294 adult male 30day    1232 adult female 01day    1374 adult female 05day    1659 adult female 30day    1653 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0037648 expression level Developmental Stage   Expression Level embryo 00-02hr    2850 embryo 02-04hr    2940 embryo 04-06hr    2489 embryo 06-08hr    2403 embryo 08-10hr    2370 embryo 10-12hr    2382 embryo 12-14hr    1614 embryo 14-16hr    1564 embryo 16-18hr    1394 embryo 18-20hr    1121 embryo 20-22hr    1933 embryo 22-24hr    1536 larva L1    798 larva L2    737 larva L3 12hr old    640 larva L3 puffstage 1-2    1343 larva L3 puffstage 3-6    2150 larva L3 puffstage 7-9    3110 white prepupae new    3014 white prepupae 12hr    1898 white prepupae 24hr    1500 pupae 2d postWPP    1330 pupae 3d postWPP    895 pupae 4d postWPP    902 adult male 01day    1054 adult male 05day    1294 adult male 30day    1232 adult female 01day    1374 adult female 05day    1659 adult female 30day    1653 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (2850) embryo 02-04hr  (2940) embryo 04-06hr  (2489) embryo 06-08hr  (2403) embryo 08-10hr  (2370) embryo 10-12hr  (2382) embryo 12-14hr  (1614) embryo 14-16hr  (1564) embryo 16-18hr  (1394) embryo 18-20hr  (1121) embryo 20-22hr  (1933) embryo 22-24hr  (1536) larva L1  (798) larva L2  (737) larva L3 12hr old  (640) larva L3 puffstage 1-2  (1343) larva L3 puffstage 3-6  (2150) larva L3 puffstage 7-9  (3110) white prepupae new  (3014) white prepupae 12hr  (1898) white prepupae 24hr  (1500) pupae 2d postWPP  (1330) pupae 3d postWPP  (895) pupae 4d postWPP  (902) adult male 01day  (1054) adult male 05day  (1294) adult male 30day  (1232) adult female 01day  (1374) adult female 05day  (1659) adult female 30day  (1653) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (2850) embryo 02-04hr  (2940) embryo 04-06hr  (2489) embryo 06-08hr  2403 embryo 08-10hr  2370 embryo 10-12hr  2382 embryo 12-14hr  1614 embryo 14-16hr  1564 embryo 16-18hr    1394 embryo 18-20hr    1121 embryo 20-22hr  1933 embryo 22-24hr  1536 larva L1    798 larva L2    737 larva L3 12hr old    640 larva L3 puffstage 1-2    1343 larva L3 puffstage 3-6  2150 larva L3 puffstage 7-9  (3110) white prepupae new  (3014) white prepupae 12hr  1898 white prepupae 24hr  1500 pupae 2d postWPP    1330 pupae 3d postWPP    895 pupae 4d postWPP    902 adult male 01day    1054 adult male 05day    1294 adult male 30day    1232 adult female 01day    1374 adult female 05day  1659 adult female 30day  1653 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    2850 embryo 02-04hr    2940 embryo 04-06hr    2489 embryo 06-08hr    2403 embryo 08-10hr    2370 embryo 10-12hr    2382 embryo 12-14hr    1614 embryo 14-16hr    1564 embryo 16-18hr    1394 embryo 18-20hr    1121 embryo 20-22hr    1933 embryo 22-24hr    1536 larva L1    798 larva L2    737 larva L3 12hr old    640 larva L3 puffstage 1-2    1343 larva L3 puffstage 3-6    2150 larva L3 puffstage 7-9    3110 white prepupae new    3014 white prepupae 12hr    1898 white prepupae 24hr    1500 pupae 2d postWPP    1330 pupae 3d postWPP    895 pupae 4d postWPP    902 adult male 01day    1054 adult male 05day    1294 adult male 30day    1232 adult female 01day    1374 adult female 05day    1659 adult female 30day    1653 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    2850 embryo 02-04hr    2940 embryo 04-06hr    2489 embryo 06-08hr    2403 embryo 08-10hr    2370 embryo 10-12hr    2382 embryo 12-14hr    1614 embryo 14-16hr    1564 embryo 16-18hr    1394 embryo 18-20hr    1121 embryo 20-22hr    1933 embryo 22-24hr    1536 larva L1    798 larva L2    737 larva L3 12hr old    640 larva L3 puffstage 1-2    1343 larva L3 puffstage 3-6    2150 larva L3 puffstage 7-9    3110 white prepupae new    3014 white prepupae 12hr    1898 white prepupae 24hr    1500 pupae 2d postWPP    1330 pupae 3d postWPP    895 pupae 4d postWPP    902 adult male 01day    1054 adult male 05day    1294 adult male 30day    1232 adult female 01day    1374 adult female 05day    1659 adult female 30day    1653 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0037648    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0037648 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult tissues/organs expressed at moderate levels. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male accessory gland, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0037648 expression level Tissue   Expression Level Larval Central Nervous System    108.6 Larval Midgut    285 Larval Hindgut    159.7 Larval Malpighian Tubules    394.9 Larval Fat Body    221.6 Larval Salivary Gland    164.2 Larval Trachea    126.275 Larval Carcass    136.5 Adult Head    154.5 Adult Eye    156.8 Adult Brain    176.9 Adult Thoracic-Abdominal Ganglion    127.8 Adult Crop    111.1 Adult Midgut    269.1 Adult Hindgut    177.1 Adult Malpighian Tubules    245.7 Adult Fat Body    192.1 Adult Salivary Gland    194.9 Adult Heart    167.1 Adult VirginFemale Spermatheca    134 Adult InseminatedFemale Spermatheca    130.1 Adult Ovary    172 Adult Testis    66.4 Adult Male Accessory Gland    175.9 Adult Carcass    134 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    108.6 Larval Midgut    285 Larval Hindgut    159.7 Larval Malpighian Tubules    394.9 Larval Fat Body    221.6 Larval Salivary Gland    164.2 Larval Trachea    126.275 Larval Carcass    136.5 Adult Head    154.5 Adult Eye    156.8 Adult Brain    176.9 Adult Thoracic-Abdominal Ganglion    127.8 Adult Crop    111.1 Adult Midgut    269.1 Adult Hindgut    177.1 Adult Malpighian Tubules    245.7 Adult Fat Body    192.1 Adult Salivary Gland    194.9 Adult Heart    167.1 Adult VirginFemale Spermatheca    134 Adult InseminatedFemale Spermatheca    130.1 Adult Ovary    172 Adult Testis    66.4 Adult Male Accessory Gland    175.9 Adult Carcass    134 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    108.6 Larval Midgut    285 Larval Hindgut    159.7 Larval Malpighian Tubules    394.9 Larval Fat Body    221.6 Larval Salivary Gland    164.2 Larval Trachea    126.275 Larval Carcass    136.5 Adult Head    154.5 Adult Eye    156.8 Adult Brain    176.9 Adult Thoracic-Abdominal Ganglion    127.8 Adult Crop    111.1 Adult Midgut    269.1 Adult Hindgut    177.1 Adult Malpighian Tubules    245.7 Adult Fat Body    192.1 Adult Salivary Gland    194.9 Adult Heart    167.1 Adult VirginFemale Spermatheca    134 Adult InseminatedFemale Spermatheca    130.1 Adult Ovary    172 Adult Testis    66.4 Adult Male Accessory Gland    175.9 Adult Carcass    134 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    108.6 Larval Midgut    285 Larval Hindgut    159.7 Larval Malpighian Tubules    394.9 Larval Fat Body    221.6 Larval Salivary Gland    164.2 Larval Trachea    126.275 Larval Carcass    136.5 Adult Head    154.5 Adult Eye    156.8 Adult Brain    176.9 Adult Thoracic-Abdominal Ganglion    127.8 Adult Crop    111.1 Adult Midgut    269.1 Adult Hindgut    177.1 Adult Malpighian Tubules    245.7 Adult Fat Body    192.1 Adult Salivary Gland    194.9 Adult Heart    167.1 Adult VirginFemale Spermatheca    134 Adult InseminatedFemale Spermatheca    130.1 Adult Ovary    172 Adult Testis    66.4 Adult Male Accessory Gland    175.9 Adult Carcass    134 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0037648 expression level Tissue   Expression Level Larval Central Nervous System    108.6 Larval Midgut    285 Larval Hindgut    159.7 Larval Malpighian Tubules    394.9 Larval Fat Body    221.6 Larval Salivary Gland    164.2 Larval Trachea    126.275 Larval Carcass    136.5 Adult Head    154.5 Adult Eye    156.8 Adult Brain    176.9 Adult Thoracic-Abdominal Ganglion    127.8 Adult Crop    111.1 Adult Midgut    269.1 Adult Hindgut    177.1 Adult Malpighian Tubules    245.7 Adult Fat Body    192.1 Adult Salivary Gland    194.9 Adult Heart    167.1 Adult VirginFemale Spermatheca    134 Adult InseminatedFemale Spermatheca    130.1 Adult Ovary    172 Adult Testis    66.4 Adult Male Accessory Gland    175.9 Adult Carcass    134 Expression Level Scale  None   Low   Moderate   High  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    108.6 Larval Midgut    285 Larval Hindgut    159.7 Larval Malpighian Tubules    394.9 Larval Fat Body    221.6 Larval Salivary Gland    164.2 Larval Trachea    126.275 Larval Carcass    136.5 Adult Head    154.5 Adult Eye    156.8 Adult Brain    176.9 Adult Thoracic-Abdominal Ganglion    127.8 Adult Crop    111.1 Adult Midgut    269.1 Adult Hindgut    177.1 Adult Malpighian Tubules    245.7 Adult Fat Body    192.1 Adult Salivary Gland    194.9 Adult Heart    167.1 Adult VirginFemale Spermatheca    134 Adult InseminatedFemale Spermatheca    130.1 Adult Ovary    172 Adult Testis    66.4 Adult Male Accessory Gland    175.9 Adult Carcass    134 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    108.6 Larval Midgut    285 Larval Hindgut    159.7 Larval Malpighian Tubules    394.9 Larval Fat Body    221.6 Larval Salivary Gland    164.2 Larval Trachea    126.275 Larval Carcass    136.5 Adult Head    154.5 Adult Eye    156.8 Adult Brain    176.9 Adult Thoracic-Abdominal Ganglion    127.8 Adult Crop    111.1 Adult Midgut    269.1 Adult Hindgut    177.1 Adult Malpighian Tubules    245.7 Adult Fat Body    192.1 Adult Salivary Gland    194.9 Adult Heart    167.1 Adult VirginFemale Spermatheca    134 Adult InseminatedFemale Spermatheca    130.1 Adult Ovary    172 Adult Testis    66.4 Adult Male Accessory Gland    175.9 Adult Carcass    134 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    108.6 Larval Midgut    285 Larval Hindgut    159.7 Larval Malpighian Tubules    394.9 Larval Fat Body    221.6 Larval Salivary Gland    164.2 Larval Trachea    126.275 Larval Carcass    136.5 Adult Head    154.5 Adult Eye    156.8 Adult Brain    176.9 Adult Thoracic-Abdominal Ganglion    127.8 Adult Crop    111.1 Adult Midgut    269.1 Adult Hindgut    177.1 Adult Malpighian Tubules    245.7 Adult Fat Body    192.1 Adult Salivary Gland    194.9 Adult Heart    167.1 Adult VirginFemale Spermatheca    134 Adult InseminatedFemale Spermatheca    130.1 Adult Ovary    172 Adult Testis    66.4 Adult Male Accessory Gland    175.9 Adult Carcass    134 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    154.5   NA  Eye    156.8   NA  Brain    176.9   108.6  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    127.8   NA  Crop    111.1   285  Midgut    269.1   159.7  Hindgut    177.1   394.9  Malpighian Tubules    245.7   221.6  Fat Body    192.1   164.2  Salivary Gland    194.9   NA  Heart    167.1   126.275  Trachea    NA   NA  VirginFemale Spermatheca    134   NA  InseminatedFemale Spermatheca    130.1   NA  Ovary    172   NA  Testis    66.4   NA  Male Accessory Gland    175.9   136.5  Carcass    134 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_05
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0037648 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG11975-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable CG11975d06507 viable, with Scer\GAL4pnr-MD237 CG11975GD12639 Sterility Allele fertile CG11975d06507 Phenotype manifest in Allele
Classical Alleles ( 1 )
For All Classical Alleles Show
Allele of CG11975 Class Mutagen Stocks Known lesion CG11975d06507 P-element activity 2 --
Alleles Carried on Transgenic Constructs ( 2 )
For All Alleles Carried on Transgenic Constructs Show
Allele of CG11975 Class Mutagen Stocks Known lesion CG11975GD12639 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes CG11975KK100592 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes
Aneuploid Aberrations
Disrupted in	Df(3R)Exel6258 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD12639} NA P{KK100592} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{XP}CG11975d06507 NA
Gene Ontology: Function, Process & Cellular Component ( 0 unique terms )
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 0 terms )
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions CG11975 allele Gene References
External Data
Linkouts	DroID - A comprehensive database of gene and protein interactions. • FBgn0037648 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 41074
Orthologs
Genome-wide drosophilid orthologs	Dana\GF16573 Dere\GG14096 Dgri\GH19377 Dmoj\GI22579 Dper\GL12110 Dpse\GA11305 Dsec\GM23775 Dsim\GD18585 Dvir\GJ10301 Dwil\GK11674 Dyak\GE25918
Curated drosophilid orthologs	Dpse\GA11305
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL010791-PA Aedes aegypti (mosquito) AGAP012792-PA Anopheles gambiae (mosquito) XP_396423.3 Apis mellifera (honey bee) XP_001951892.1 Acyrthosiphon pisum (pea aphid) At3g62770.2 Arabidopsis thaliana (wall cress) 2949 Batrachochytrium dendrobatidis (chytrid fungus) 119014 Branchiostoma floridae (lancelet) 259895 Branchiostoma floridae (lancelet) XP_001902430.1 Brugia malayi (roundworm nematode) BGIBMGA007298-PA Bombyx mori (silk worm) ENSBTAP00000004811 Bos taurus (bovine) CAL0000996 Candida albicans (a form of yeast) CN29556 Caenorhabditis brenneri (small nematode) CBP10822 Caenorhabditis briggsae (nematode) CE33216 Caenorhabditis elegans (worm) ENSCAFP00000019165 Canis familiaris (dog) CAGL0B02101g Candida glabrata (haploid yeast) ENSCINP00000016797 Ciona intestinalis (sea squirt) JA17842 Caenorhabditis japonica (nematode) CPIJ009443 Culex pipens (mosquito) ENSCPOP00000005100 Cavia porcellus (guinea pig) 187711 Chlamidomonas reinhardtii (green alga) RP43002 Caenorhabditis remanei (nematode) ENSCSAVP00000008114 Ciona savignyi (sedentary tunicate) 164513 Capitella spl (polychaete worm) DDB0235214 Dictyostelium discoideum (amoeba) DEHA2C07084g Debaryomyces Hansenii (yeast) 324944 Daphnia pulex (daphnia) ENSDARP00000037790 Danio rerio (zebra fish) ENSECAP00000012478 Equus caballus (horse) XP_648446 Entamoeba histolytica (anaerobic protozoan) XP_654286 Entamoeba histolytica (anaerobic protozoan) ENSGACP00000020076 Gymnopilus aculeatus (mushroom) ENSGALP00000002372 Gallus gallus (chicken) GL50803_10822 Giardia lamblia (flagellated protozoan) 185925 Hypsipyla robusta (cedar shoot borer) ENSP00000376139 Homo sapiens (human) ISCW012477-PA Ixodes scapularis (deer tick) KLLA0E15885g Kluyveromyces lactis (yeast) 205870 Lottia gigantea (owl limpet) 15101 Monocosta brevicollis (choanoflagellate) ENSMODP00000009032 Monodelphis domestica (gray opossum) ENSMMUP00000028716 Macaca mulatta (rhesus monkey) ENSMUSP00000026173 Mus musculus (house mouse) 172497 Nematostella vectensis (starlet anemone) XP_001607565.1 Nasonia vitripennis (wasp) ENSOANP00000019885 Ornithorynchus anatinus (platypus) ENSORLP00000016272 Oryzias latipes (japanese killifish) LOC_Os01g70780.1 Oryza sativa (asian rice) 17754 Ostreococcus tauri (green alga) PF10_0126 Plasmodium falciparum (protozoal parasite) PHUM003464-PA Pediculus humanus (human body louse) PP14954 Pristionchus pacificus (nematode) 122793 Physcomitrella patens (moss) ENSPPYP00000009860 Pongo pygmaeus (orangutan) 74426 Phytophthora ramorum (sudden oak death pathogen) 145353 Phytophthora sojae (root rot pathogen) 243527 Populus trichocarpa (black cottonwood) ENSPTRP00000016688 Pan troglodytes (chimpanzee) PVX_094865 Plasmodium vivax (protozoal parasite) ENSRNOP00000051801 Rattus norvegicus (norway rat) 5054331 Sorghum bicolor (sorghum) YGR223C Saccharomyces cerevisiae (budding yeast) Smp_154110 Schistosoma mansoni (trematode parasite) SPAC458.06 Schizosaccharomyces pombe (fission yeast) XP_792976.1 Strongylocentrotus purpuratus (purple sea urchin) 20943 Trichoplax adhaerens (metazoa) TA03100 Theileria annulata (apicomplexan parasite) XP_968172.1 Tribolium castaneum (red flour beetle) ENSTNIP00000013139 Tetraodon nigroviridis (green spotted pufferfish) TP01_0622 Theileria parva (parasitic protozoan) 37942 Thalassiosira pseudonana (marine diatom) ENSTRUP00000008582 Takifugu rubripes (pufferfish Takifugu) 3812.m02709 Tetrahymena thermophila (ciliate protozoa) 81412.m00068 Trichomonas vaginalis (parasitic flagellated protozoan) ENSXETP00000049343 Xenopus tropicalis (frog) YALI0B15290g Yarrowia lipolytica (nonconventional yeast) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV14512 LH20463 ISCW012477 FBgn0242967 FBgn0213685 FBgn0197587 FBgn0190107 FBgn0178640 JGI_V11_324944 FBgn0071359 FBgn0149718 FBgn0145307 FBgn0126842 FBgn0106358 FBgn0093594 CPIJ009443 BGIBMGA007298 ACYPI005791 GB19471 AGAP012792 AGAP004138 AAEL010791 PB23431 PHUM328130 GLEAN_15973
Stocks & Reagents
Stocks Listed in FlyBase ( 5 )
Bloomington	19243 w1118; P{XP}CG11975d06507
Harvard	- P{XP}CG11975d06507
VDRC	v108549 P{KK100592}VIE-260B v26799 w1118; P{GD12639}v26799 v26800 w1118; P{GD12639}v26800
Genomic Clones ( 2 )
	BACR02G22 BACR09F04 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 87 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD32381
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	LD20669 LD45626 LD45827 RE05135 RE15868 RE15981 RE25579 RE26334 RE53102 RE57779 RE60230 RE73504 RH27994 RH32264 RH35084 RH36191 RH73554 SD05965 SD26437
Other clones	Dmel_neb_013228_0655_1247 EC35543 EK043455 EK053854 EK058340 EK061939 EK070238 EK091042 EK099260 EK109650 EK116060 EK119234 EK130322 EK135039 EK153904 EK155761 EK186203 EK213303 EK227108 EK235244 EK255020 EK270267 EK296828 EN04835 ESG012a.E21_H08 ESG019d.E21_A01 FGM322G08 RP001003315 RP001014917 RP001014944 RP001015757 RP001016708 RP001017421 RP001018039 RP001019381 RP001019870 RP001020118 RP001020339 RP001020961 RP001022084 RP001022220 RP001022269 RP001023078 RP001023965 RP001024054 RP001024635 RP001025245 RP001026125 RP001030956 RP001032995 RP001034919 RP001039681 RP001040646 RP001043508 RP001043585 RP001043991 RP001044248 RP001045803 RP001046362 RP001046931 RP001047335 RP001047407 RP001051611 RP001052025 RP001052489 RP001056058 RP001056305
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0037648 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 41074
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_141596 RefSeq (Proteins) • NP_649853 DDBJ / EMBL / GenBank • AA951707 AAF54315 AW943132 CZ475174 CZ475175 Entrez Gene - A searchable database of RefSeq genes. • 41074 UniProtKB/TrEMBL • Q9VHJ2
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • WD40 repeat (IPR001680) WD40 repeat-like-containing domain (IPR011046) WD40-repeat-containing domain (IPR017986) WD40/YVTN repeat-like-containing domain (IPR015943) WD40 repeat, subgroup (IPR019781)
Linkouts
	DroID - A comprehensive database of gene and protein interactions. • FBgn0037648 DRSC - Results from RNAi screens. • FBgn0037648 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0037648 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG11975-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0037648 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 41074 InParanoid A subset of ortholog calls from InParanoid. • AAEL010791-PA Aedes aegypti (mosquito) AGAP012792-PA Anopheles gambiae (mosquito) XP_396423.3 Apis mellifera (honey bee) XP_001951892.1 Acyrthosiphon pisum (pea aphid) At3g62770.2 Arabidopsis thaliana (wall cress) 2949 Batrachochytrium dendrobatidis (chytrid fungus) 119014 Branchiostoma floridae (lancelet) 259895 Branchiostoma floridae (lancelet) XP_001902430.1 Brugia malayi (roundworm nematode) BGIBMGA007298-PA Bombyx mori (silk worm) ENSBTAP00000004811 Bos taurus (bovine) CAL0000996 Candida albicans (a form of yeast) CN29556 Caenorhabditis brenneri (small nematode) CBP10822 Caenorhabditis briggsae (nematode) CE33216 Caenorhabditis elegans (worm) ENSCAFP00000019165 Canis familiaris (dog) CAGL0B02101g Candida glabrata (haploid yeast) ENSCINP00000016797 Ciona intestinalis (sea squirt) JA17842 Caenorhabditis japonica (nematode) CPIJ009443 Culex pipens (mosquito) ENSCPOP00000005100 Cavia porcellus (guinea pig) 187711 Chlamidomonas reinhardtii (green alga) RP43002 Caenorhabditis remanei (nematode) ENSCSAVP00000008114 Ciona savignyi (sedentary tunicate) 164513 Capitella spl (polychaete worm) DDB0235214 Dictyostelium discoideum (amoeba) DEHA2C07084g Debaryomyces Hansenii (yeast) 324944 Daphnia pulex (daphnia) ENSDARP00000037790 Danio rerio (zebra fish) ENSECAP00000012478 Equus caballus (horse) XP_648446 Entamoeba histolytica (anaerobic protozoan) XP_654286 Entamoeba histolytica (anaerobic protozoan) ENSGACP00000020076 Gymnopilus aculeatus (mushroom) ENSGALP00000002372 Gallus gallus (chicken) GL50803_10822 Giardia lamblia (flagellated protozoan) 185925 Hypsipyla robusta (cedar shoot borer) ENSP00000376139 Homo sapiens (human) ISCW012477-PA Ixodes scapularis (deer tick) KLLA0E15885g Kluyveromyces lactis (yeast) 205870 Lottia gigantea (owl limpet) 15101 Monocosta brevicollis (choanoflagellate) ENSMODP00000009032 Monodelphis domestica (gray opossum) ENSMMUP00000028716 Macaca mulatta (rhesus monkey) ENSMUSP00000026173 Mus musculus (house mouse) 172497 Nematostella vectensis (starlet anemone) XP_001607565.1 Nasonia vitripennis (wasp) ENSOANP00000019885 Ornithorynchus anatinus (platypus) ENSORLP00000016272 Oryzias latipes (japanese killifish) LOC_Os01g70780.1 Oryza sativa (asian rice) 17754 Ostreococcus tauri (green alga) PF10_0126 Plasmodium falciparum (protozoal parasite) PHUM003464-PA Pediculus humanus (human body louse) PP14954 Pristionchus pacificus (nematode) 122793 Physcomitrella patens (moss) ENSPPYP00000009860 Pongo pygmaeus (orangutan) 74426 Phytophthora ramorum (sudden oak death pathogen) 145353 Phytophthora sojae (root rot pathogen) 243527 Populus trichocarpa (black cottonwood) ENSPTRP00000016688 Pan troglodytes (chimpanzee) PVX_094865 Plasmodium vivax (protozoal parasite) ENSRNOP00000051801 Rattus norvegicus (norway rat) 5054331 Sorghum bicolor (sorghum) YGR223C Saccharomyces cerevisiae (budding yeast) Smp_154110 Schistosoma mansoni (trematode parasite) SPAC458.06 Schizosaccharomyces pombe (fission yeast) XP_792976.1 Strongylocentrotus purpuratus (purple sea urchin) 20943 Trichoplax adhaerens (metazoa) TA03100 Theileria annulata (apicomplexan parasite) XP_968172.1 Tribolium castaneum (red flour beetle) ENSTNIP00000013139 Tetraodon nigroviridis (green spotted pufferfish) TP01_0622 Theileria parva (parasitic protozoan) 37942 Thalassiosira pseudonana (marine diatom) ENSTRUP00000008582 Takifugu rubripes (pufferfish Takifugu) 3812.m02709 Tetrahymena thermophila (ciliate protozoa) 81412.m00068 Trichomonas vaginalis (parasitic flagellated protozoan) ENSXETP00000049343 Xenopus tropicalis (frog) YALI0B15290g Yarrowia lipolytica (nonconventional yeast) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 41074 modMine - Data generated by the modENCODE project. • FBgn0037648 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV14512 LH20463 ISCW012477 FBgn0242967 FBgn0213685 FBgn0197587 FBgn0190107 FBgn0178640 JGI_V11_324944 FBgn0071359 FBgn0149718 FBgn0145307 FBgn0126842 FBgn0106358 FBgn0093594 CPIJ009443 BGIBMGA007298 ACYPI005791 GB19471 AGAP012792 AGAP004138 AAEL010791 PB23431 PHUM328130 GLEAN_15973
Synonyms & Secondary IDs ( 2 )
Reported As
Symbol Synonym	CG11975 (Michell, 2006, Weiler, 2007, Keleman et al., 2009.8.5)
Name Synonym	PROPPIN-3 (Michell, 2006)
Secondary FlyBase IDs
References ( 15 )
Research paper	Weiler, 2007, Genetics 177(1): 167--178 E(var)3-9 of Drosophila melanogaster Encodes a Zinc Finger Protein. [FBrf0201244] Dove et al., 2004, EMBO J. 23(9): 1922--1933 Svp1p defines a family of phosphatidylinositol 3,5-bisphosphate effectors. [FBrf0179764]
Supplementary material	The modENCODE Consortium, 2010, Science 330(6012): DataS14: Gene co-expression clusters. [FBrf0213979] Mummery-Widmer et al., 2009, Nature 458(7241): Supplementary Table 2 - Genome-wide bristle screen results. [FBrf0214518]
Review	Michell, 2006, Trends Biochem. Sci. 31(1): 52--63 [FBrf0198764]
Personal communication to FlyBase	Keleman et al., 2009.8.5, RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0208510] Dickson et al., 2007.7.18, RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0200327] Bloomington Drosophila Stock Center, 2004.11.6, Exelixis insertion alleles that are not in FlyBase. Exelixis insertion alleles that are not in FlyBase. [FBrf0179797] Ryder, 2004.4.26, Exelixis CG deletion data. Exelixis CG deletion data. [FBrf0184335]
FlyBase analysis	FlyBase, 1992-, FlyBase curation FlyBase curation. [FBrf0105495]
Computer file	Gene Disruption Project members and Exelixis, 2005, Genomic mapping of Exelixis insertion collection. Genomic mapping of Exelixis insertion collection. [FBrf0184340] Gene Disruption Project members, 2001-, [title not yet available] [title not yet available] [FBrf0132177] BDGP Project Members, 2000-, Berkeley Drosophila Genome Project. Berkeley Drosophila Genome Project. [FBrf0125078]
Automatic genome annotation	FamiliarityBreedsContempt, 1999.11, [Annotations performed at the Celera Jamboreee.] [Annotations performed at the Celera Jamboreee.] [FBrf0126705]