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Gene Dmel\CG18005

General Information
Symbol	Dmel\CG18005	Species	D. melanogaster
Name		Annotation symbol	CG18005
Feature type	protein_coding_gene	FlyBase ID	FBgn0037660
Gene Model Status	Current	Stock availability	4 publicly available
Genomic Location
Chromosome (arm)	3R	Recombination map
Cytogenetic map	85C4-85C4	Sequence location	3R:4,888,854..4,890,819 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	This gene is referred to in FlyBase by the symbol Dmel\CG18005 (FBgn0037660). It is a protein_coding_gene from Drosophila melanogaster. Its molecular function is unknown. It is reported to be involved in the biological process: nuclear mRNA splicing, via spliceosome. 4 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: RED-like, C-terminal; RED-like, N-terminal. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression. Peak expression observed at stages throughout embryogenesis, at stages throughout the pupal period, in adult female stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult brain. Comments on Affy2 ProbeSet: ProbeSet 1630176_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of CG18005. Gene sequence location is 3R:4888854..4890819.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2011_10
FB2012_01	Sequence features BKN22866 HFA15296
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 85C4-85C4   Limits computationally determined from genome sequence between P{lacW}l(3)L4740L4740 and P{EP}D1EP473
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\CG18005 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) CG18005-RA FBtr0081995  NM_141608   1901   557
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein CG18005-PA   FBpp0081475   61.4   557   6.83     NP_649865   AAF54336
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • RED-like, C-terminal (IPR012492) RED-like, N-terminal (IPR012916)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA246902   AA264314   AA735460   AA978541   AE014297 AAF54336   AI455131   AQ073862   AY069471 AAL39616   BF486249   BF487231   BF493565   BI170831   BI173572   BI482050   BI630980   BI640800   CO319863   GH754274   GH755906   GH759907   GH770452   GH781753   GH782720   GH791785   GH802841   GH806215   GH808187   GH822800   GH827556   GH833694   GH848008   GH852765   GH853265   GH867718   GH878219   GH903406   GH907953   GH909473   GH924744   GH925208   GH926758   GH933110   GH942376
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9VHH8
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0037660    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0037660 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression. Peak expression observed at stages throughout embryogenesis, at stages throughout the pupal period, in adult female stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0037660 expression level Developmental Stage   Expression Level embryo 00-02hr    2997 embryo 02-04hr    3550 embryo 04-06hr    2679 embryo 06-08hr    3226 embryo 08-10hr    2700 embryo 10-12hr    2606 embryo 12-14hr    1918 embryo 14-16hr    1863 embryo 16-18hr    1546 embryo 18-20hr    1246 embryo 20-22hr    1900 embryo 22-24hr    1558 larva L1    816 larva L2    729 larva L3 12hr old    603 larva L3 puffstage 1-2    699 larva L3 puffstage 3-6    964 larva L3 puffstage 7-9    1128 white prepupae new    1184 white prepupae 12hr    1248 white prepupae 24hr    1720 pupae 2d postWPP    1446 pupae 3d postWPP    949 pupae 4d postWPP    721 adult male 01day    881 adult male 05day    1079 adult male 30day    1020 adult female 01day    980 adult female 05day    1466 adult female 30day    1505 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (2997) embryo 02-04hr  (3550) embryo 04-06hr  (2679) embryo 06-08hr  (3226) embryo 08-10hr  (2700) embryo 10-12hr  (2606) embryo 12-14hr  (1918) embryo 14-16hr  (1863) embryo 16-18hr  (1546) embryo 18-20hr  (1246) embryo 20-22hr  (1900) embryo 22-24hr  (1558) larva L1  (816) larva L2  (729) larva L3 12hr old  (603) larva L3 puffstage 1-2  (699) larva L3 puffstage 3-6  (964) larva L3 puffstage 7-9  (1128) white prepupae new  (1184) white prepupae 12hr  (1248) white prepupae 24hr  (1720) pupae 2d postWPP  (1446) pupae 3d postWPP  (949) pupae 4d postWPP  (721) adult male 01day  (881) adult male 05day  (1079) adult male 30day  (1020) adult female 01day  (980) adult female 05day  (1466) adult female 30day  (1505) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (2997) embryo 02-04hr  (3550) embryo 04-06hr  (2679) embryo 06-08hr  (3226) embryo 08-10hr  (2700) embryo 10-12hr  (2606) embryo 12-14hr  (1918) embryo 14-16hr  (1863) embryo 16-18hr  (1546) embryo 18-20hr    1246 embryo 20-22hr  (1900) embryo 22-24hr  (1558) larva L1    816 larva L2    729 larva L3 12hr old    603 larva L3 puffstage 1-2    699 larva L3 puffstage 3-6    964 larva L3 puffstage 7-9    1128 white prepupae new    1184 white prepupae 12hr    1248 white prepupae 24hr  (1720) pupae 2d postWPP  1446 pupae 3d postWPP    949 pupae 4d postWPP    721 adult male 01day    881 adult male 05day    1079 adult male 30day    1020 adult female 01day    980 adult female 05day  1466 adult female 30day  1505 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    2997 embryo 02-04hr    3550 embryo 04-06hr    2679 embryo 06-08hr    3226 embryo 08-10hr    2700 embryo 10-12hr    2606 embryo 12-14hr    1918 embryo 14-16hr    1863 embryo 16-18hr    1546 embryo 18-20hr    1246 embryo 20-22hr    1900 embryo 22-24hr    1558 larva L1    816 larva L2    729 larva L3 12hr old    603 larva L3 puffstage 1-2    699 larva L3 puffstage 3-6    964 larva L3 puffstage 7-9    1128 white prepupae new    1184 white prepupae 12hr    1248 white prepupae 24hr    1720 pupae 2d postWPP    1446 pupae 3d postWPP    949 pupae 4d postWPP    721 adult male 01day    881 adult male 05day    1079 adult male 30day    1020 adult female 01day    980 adult female 05day    1466 adult female 30day    1505 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    2997 embryo 02-04hr    3550 embryo 04-06hr    2679 embryo 06-08hr    3226 embryo 08-10hr    2700 embryo 10-12hr    2606 embryo 12-14hr    1918 embryo 14-16hr    1863 embryo 16-18hr    1546 embryo 18-20hr    1246 embryo 20-22hr    1900 embryo 22-24hr    1558 larva L1    816 larva L2    729 larva L3 12hr old    603 larva L3 puffstage 1-2    699 larva L3 puffstage 3-6    964 larva L3 puffstage 7-9    1128 white prepupae new    1184 white prepupae 12hr    1248 white prepupae 24hr    1720 pupae 2d postWPP    1446 pupae 3d postWPP    949 pupae 4d postWPP    721 adult male 01day    881 adult male 05day    1079 adult male 30day    1020 adult female 01day    980 adult female 05day    1466 adult female 30day    1505 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0037660 expression level Developmental Stage   Expression Level embryo 00-02hr    2997 embryo 02-04hr    3550 embryo 04-06hr    2679 embryo 06-08hr    3226 embryo 08-10hr    2700 embryo 10-12hr    2606 embryo 12-14hr    1918 embryo 14-16hr    1863 embryo 16-18hr    1546 embryo 18-20hr    1246 embryo 20-22hr    1900 embryo 22-24hr    1558 larva L1    816 larva L2    729 larva L3 12hr old    603 larva L3 puffstage 1-2    699 larva L3 puffstage 3-6    964 larva L3 puffstage 7-9    1128 white prepupae new    1184 white prepupae 12hr    1248 white prepupae 24hr    1720 pupae 2d postWPP    1446 pupae 3d postWPP    949 pupae 4d postWPP    721 adult male 01day    881 adult male 05day    1079 adult male 30day    1020 adult female 01day    980 adult female 05day    1466 adult female 30day    1505 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (2997) embryo 02-04hr  (3550) embryo 04-06hr  (2679) embryo 06-08hr  (3226) embryo 08-10hr  (2700) embryo 10-12hr  (2606) embryo 12-14hr  (1918) embryo 14-16hr  (1863) embryo 16-18hr  (1546) embryo 18-20hr  (1246) embryo 20-22hr  (1900) embryo 22-24hr  (1558) larva L1  (816) larva L2  (729) larva L3 12hr old  (603) larva L3 puffstage 1-2  (699) larva L3 puffstage 3-6  (964) larva L3 puffstage 7-9  (1128) white prepupae new  (1184) white prepupae 12hr  (1248) white prepupae 24hr  (1720) pupae 2d postWPP  (1446) pupae 3d postWPP  (949) pupae 4d postWPP  (721) adult male 01day  (881) adult male 05day  (1079) adult male 30day  (1020) adult female 01day  (980) adult female 05day  (1466) adult female 30day  (1505) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (2997) embryo 02-04hr  (3550) embryo 04-06hr  (2679) embryo 06-08hr  (3226) embryo 08-10hr  (2700) embryo 10-12hr  (2606) embryo 12-14hr  1918 embryo 14-16hr  1863 embryo 16-18hr  1546 embryo 18-20hr    1246 embryo 20-22hr  1900 embryo 22-24hr  1558 larva L1    816 larva L2    729 larva L3 12hr old    603 larva L3 puffstage 1-2    699 larva L3 puffstage 3-6    964 larva L3 puffstage 7-9    1128 white prepupae new    1184 white prepupae 12hr    1248 white prepupae 24hr  1720 pupae 2d postWPP  1446 pupae 3d postWPP    949 pupae 4d postWPP    721 adult male 01day    881 adult male 05day    1079 adult male 30day    1020 adult female 01day    980 adult female 05day  1466 adult female 30day  1505 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    2997 embryo 02-04hr    3550 embryo 04-06hr    2679 embryo 06-08hr    3226 embryo 08-10hr    2700 embryo 10-12hr    2606 embryo 12-14hr    1918 embryo 14-16hr    1863 embryo 16-18hr    1546 embryo 18-20hr    1246 embryo 20-22hr    1900 embryo 22-24hr    1558 larva L1    816 larva L2    729 larva L3 12hr old    603 larva L3 puffstage 1-2    699 larva L3 puffstage 3-6    964 larva L3 puffstage 7-9    1128 white prepupae new    1184 white prepupae 12hr    1248 white prepupae 24hr    1720 pupae 2d postWPP    1446 pupae 3d postWPP    949 pupae 4d postWPP    721 adult male 01day    881 adult male 05day    1079 adult male 30day    1020 adult female 01day    980 adult female 05day    1466 adult female 30day    1505 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    2997 embryo 02-04hr    3550 embryo 04-06hr    2679 embryo 06-08hr    3226 embryo 08-10hr    2700 embryo 10-12hr    2606 embryo 12-14hr    1918 embryo 14-16hr    1863 embryo 16-18hr    1546 embryo 18-20hr    1246 embryo 20-22hr    1900 embryo 22-24hr    1558 larva L1    816 larva L2    729 larva L3 12hr old    603 larva L3 puffstage 1-2    699 larva L3 puffstage 3-6    964 larva L3 puffstage 7-9    1128 white prepupae new    1184 white prepupae 12hr    1248 white prepupae 24hr    1720 pupae 2d postWPP    1446 pupae 3d postWPP    949 pupae 4d postWPP    721 adult male 01day    881 adult male 05day    1079 adult male 30day    1020 adult female 01day    980 adult female 05day    1466 adult female 30day    1505 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0037660    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0037660 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult brain. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0037660 expression level Tissue   Expression Level Larval Central Nervous System    82.75 Larval Midgut no informative data Larval Hindgut    31.4 Larval Malpighian Tubules    31.4 Larval Fat Body no informative data Larval Salivary Gland    56.7 Larval Trachea    49.175 Larval Carcass no informative data Adult Head    48.4 Adult Eye    76.25 Adult Brain    112.2 Adult Thoracic-Abdominal Ganglion    61.1 Adult Crop    53 Adult Midgut    31.6 Adult Hindgut    37.7 Adult Malpighian Tubules    46.7 Adult Fat Body no informative data Adult Salivary Gland    52.7 Adult Heart    33.15 Adult VirginFemale Spermatheca    25.9 Adult InseminatedFemale Spermatheca no informative data Adult Ovary    78.9 Adult Testis    58.3 Adult Male Accessory Gland    29.2 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    82.75 Larval Midgut no informative data Larval Hindgut    31.4 Larval Malpighian Tubules    31.4 Larval Fat Body no informative data Larval Salivary Gland    56.7 Larval Trachea    49.175 Larval Carcass no informative data Adult Head    48.4 Adult Eye    76.25 Adult Brain    112.2 Adult Thoracic-Abdominal Ganglion    61.1 Adult Crop    53 Adult Midgut    31.6 Adult Hindgut    37.7 Adult Malpighian Tubules    46.7 Adult Fat Body no informative data Adult Salivary Gland    52.7 Adult Heart    33.15 Adult VirginFemale Spermatheca    25.9 Adult InseminatedFemale Spermatheca no informative data Adult Ovary    78.9 Adult Testis    58.3 Adult Male Accessory Gland    29.2 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    82.75 Larval Midgut no informative data Larval Hindgut    31.4 Larval Malpighian Tubules    31.4 Larval Fat Body no informative data Larval Salivary Gland    56.7 Larval Trachea    49.175 Larval Carcass no informative data Adult Head    48.4 Adult Eye    76.25 Adult Brain    112.2 Adult Thoracic-Abdominal Ganglion    61.1 Adult Crop    53 Adult Midgut    31.6 Adult Hindgut    37.7 Adult Malpighian Tubules    46.7 Adult Fat Body no informative data Adult Salivary Gland    52.7 Adult Heart    33.15 Adult VirginFemale Spermatheca    25.9 Adult InseminatedFemale Spermatheca no informative data Adult Ovary    78.9 Adult Testis    58.3 Adult Male Accessory Gland    29.2 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    82.75 Larval Midgut no informative data Larval Hindgut    31.4 Larval Malpighian Tubules    31.4 Larval Fat Body no informative data Larval Salivary Gland    56.7 Larval Trachea    49.175 Larval Carcass no informative data Adult Head    48.4 Adult Eye    76.25 Adult Brain    112.2 Adult Thoracic-Abdominal Ganglion    61.1 Adult Crop    53 Adult Midgut    31.6 Adult Hindgut    37.7 Adult Malpighian Tubules    46.7 Adult Fat Body no informative data Adult Salivary Gland    52.7 Adult Heart    33.15 Adult VirginFemale Spermatheca    25.9 Adult InseminatedFemale Spermatheca no informative data Adult Ovary    78.9 Adult Testis    58.3 Adult Male Accessory Gland    29.2 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0037660 expression level Tissue   Expression Level Larval Central Nervous System    82.75 Larval Midgut no informative data Larval Hindgut    31.4 Larval Malpighian Tubules    31.4 Larval Fat Body no informative data Larval Salivary Gland    56.7 Larval Trachea    49.175 Larval Carcass no informative data Adult Head    48.4 Adult Eye    76.25 Adult Brain    112.2 Adult Thoracic-Abdominal Ganglion    61.1 Adult Crop    53 Adult Midgut    31.6 Adult Hindgut    37.7 Adult Malpighian Tubules    46.7 Adult Fat Body no informative data Adult Salivary Gland    52.7 Adult Heart    33.15 Adult VirginFemale Spermatheca    25.9 Adult InseminatedFemale Spermatheca no informative data Adult Ovary    78.9 Adult Testis    58.3 Adult Male Accessory Gland    29.2 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    82.75 Larval Midgut no informative data Larval Hindgut    31.4 Larval Malpighian Tubules    31.4 Larval Fat Body no informative data Larval Salivary Gland    56.7 Larval Trachea    49.175 Larval Carcass no informative data Adult Head    48.4 Adult Eye    76.25 Adult Brain    112.2 Adult Thoracic-Abdominal Ganglion    61.1 Adult Crop    53 Adult Midgut    31.6 Adult Hindgut    37.7 Adult Malpighian Tubules    46.7 Adult Fat Body no informative data Adult Salivary Gland    52.7 Adult Heart    33.15 Adult VirginFemale Spermatheca    25.9 Adult InseminatedFemale Spermatheca no informative data Adult Ovary    78.9 Adult Testis    58.3 Adult Male Accessory Gland    29.2 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    82.75 Larval Midgut no informative data Larval Hindgut    31.4 Larval Malpighian Tubules    31.4 Larval Fat Body no informative data Larval Salivary Gland    56.7 Larval Trachea    49.175 Larval Carcass no informative data Adult Head    48.4 Adult Eye    76.25 Adult Brain    112.2 Adult Thoracic-Abdominal Ganglion    61.1 Adult Crop    53 Adult Midgut    31.6 Adult Hindgut    37.7 Adult Malpighian Tubules    46.7 Adult Fat Body no informative data Adult Salivary Gland    52.7 Adult Heart    33.15 Adult VirginFemale Spermatheca    25.9 Adult InseminatedFemale Spermatheca no informative data Adult Ovary    78.9 Adult Testis    58.3 Adult Male Accessory Gland    29.2 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    82.75 Larval Midgut no informative data Larval Hindgut    31.4 Larval Malpighian Tubules    31.4 Larval Fat Body no informative data Larval Salivary Gland    56.7 Larval Trachea    49.175 Larval Carcass no informative data Adult Head    48.4 Adult Eye    76.25 Adult Brain    112.2 Adult Thoracic-Abdominal Ganglion    61.1 Adult Crop    53 Adult Midgut    31.6 Adult Hindgut    37.7 Adult Malpighian Tubules    46.7 Adult Fat Body no informative data Adult Salivary Gland    52.7 Adult Heart    33.15 Adult VirginFemale Spermatheca    25.9 Adult InseminatedFemale Spermatheca no informative data Adult Ovary    78.9 Adult Testis    58.3 Adult Male Accessory Gland    29.2 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut no informative data Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body no informative data Larval Salivary Gland     Larval Trachea     Larval Carcass no informative data Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body no informative data Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca no informative data Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass no informative data FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    48.4   NA  Eye    76.25   NA  Brain    112.2   82.75  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    61.1   NA  Crop    53   no informative data  Midgut    31.6   31.4  Hindgut    37.7   31.4  Malpighian Tubules    46.7   no informative data  Fat Body    no informative data   56.7  Salivary Gland    52.7   NA  Heart    33.15   49.175  Trachea    NA   NA  VirginFemale Spermatheca    25.9   NA  InseminatedFemale Spermatheca    no informative data   NA  Ovary    78.9   NA  Testis    58.3   NA  Male Accessory Gland    29.2   no informative data  Carcass    no informative data modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_17
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0037660 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG18005-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable, with Scer\GAL4pnr-MD237 CG18005GD9499 Other Phenotypes Allele planar polarity defective, with Scer\GAL4pnr-MD237 CG18005GD9499 Phenotype manifest in Allele germline cell | male, with Scer\GAL4ptc-559.1 CG18005EP3260
Classical Alleles ( 2 )
For All Classical Alleles Show
Allele of CG18005 Class Mutagen Stocks Known lesion CG18005EY06611 P-element activity 1 -- CG18005EP3260 P-element activity 0 --
Alleles Carried on Transgenic Constructs ( 2 )
For All Alleles Carried on Transgenic Constructs Show
Allele of CG18005 Class Mutagen Stocks Known lesion CG18005GD9499 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes CG18005KK102770 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes
Aneuploid Aberrations
Disrupted in	Df(3R)Exel6151 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD9499} NA P{KK102770} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EP}CG18005EP3260 NA P{EPgy2}CG18005EY06611 NA
Gene Ontology: Function, Process & Cellular Component ( 3 unique terms )
Terms Based on Experimental Evidence ( 2 terms )
Molecular Function ( 0 terms)
Biological Process ( 0 terms)
Cellular Component
CV term Evidence References
catalytic step 2 spliceosome inferred from direct assay (Herold et al., 2009) precatalytic spliceosome inferred from direct assay (Herold et al., 2009)
Terms Based on Predictions or Assertions ( 1 term )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
nuclear mRNA splicing, via spliceosome inferred by curator from GO:0071011|GO:0071013 (Herold et al., 2009)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions CG18005 allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 66258 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0037660 DroID - A comprehensive database of gene and protein interactions. • FBgn0037660 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 41091
Orthologs
Genome-wide drosophilid orthologs	Dana\GF18429 Dere\GG17395 Dgri\GH18236 Dmoj\GI10192 Dper\GL21550 Dpse\GA14763 Dsec\GM26285 Dsim\GD20821 Dvir\GJ23479 Dwil\GK11519 Dyak\GE24799
Curated drosophilid orthologs	Dpse\GA14763
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL009686-PA Aedes aegypti (mosquito) AGAP004738-PA Anopheles gambiae (mosquito) XP_394867.2 Apis mellifera (honey bee) XP_001945323.1 Acyrthosiphon pisum (pea aphid) At2g26460.1 Arabidopsis thaliana (wall cress) 90593 Batrachochytrium dendrobatidis (chytrid fungus) 79122 Branchiostoma floridae (lancelet) XP_001902922.1 Brugia malayi (roundworm nematode) ENSBTAP00000020011 Bos taurus (bovine) CN08807 Caenorhabditis brenneri (small nematode) CN16626 Caenorhabditis brenneri (small nematode) CBP10686 Caenorhabditis briggsae (nematode) CE25338 Caenorhabditis elegans (worm) ENSCAFP00000008794 Canis familiaris (dog) ENSCINP00000011595 Ciona intestinalis (sea squirt) cn06082 Cryptococcus neoformans (yeast-like fungus) CPIJ002511 Culex pipens (mosquito) ENSCPOP00000008241 Cavia porcellus (guinea pig) 177943 Chlamidomonas reinhardtii (green alga) RP28079 Caenorhabditis remanei (nematode) ENSCSAVP00000012560 Ciona savignyi (sedentary tunicate) 225605 Capitella spl (polychaete worm) 313838 Daphnia pulex (daphnia) ENSDARP00000009186 Danio rerio (zebra fish) ENSECAP00000011039 Equus caballus (horse) ENSGACP00000027648 Gymnopilus aculeatus (mushroom) ENSGALP00000001219 Gallus gallus (chicken) 88417 Hypsipyla robusta (cedar shoot borer) ENSP00000261812 Homo sapiens (human) ISCW018510-PA Ixodes scapularis (deer tick) 214293 Lottia gigantea (owl limpet) 34240 Monocosta brevicollis (choanoflagellate) ENSMODP00000014297 Monodelphis domestica (gray opossum) ENSMMUP00000013087 Macaca mulatta (rhesus monkey) ENSMUSP00000007042 Mus musculus (house mouse) 211930 Nematostella vectensis (starlet anemone) XP_001603111.1 Nasonia vitripennis (wasp) ENSOANP00000018475 Ornithorynchus anatinus (platypus) ENSORLP00000016298 Oryzias latipes (japanese killifish) LOC_Os11g04950.1 Oryza sativa (asian rice) 32189 Ostreococcus tauri (green alga) PHUM005458-PA Pediculus humanus (human body louse) 197602 Physcomitrella patens (moss) ENSPPYP00000017737 Pongo pygmaeus (orangutan) 75831 Phytophthora ramorum (sudden oak death pathogen) 135360 Phytophthora sojae (root rot pathogen) 778660 Populus trichocarpa (black cottonwood) ENSPTRP00000029615 Pan troglodytes (chimpanzee) PVX_122175 Plasmodium vivax (protozoal parasite) ENSRNOP00000044213 Rattus norvegicus (norway rat) 4765210 Sorghum bicolor (sorghum) Smp_004480 Schistosoma mansoni (trematode parasite) SPBC1539.02 Schizosaccharomyces pombe (fission yeast) XP_001187421.1 Strongylocentrotus purpuratus (purple sea urchin) 64358 Trichoplax adhaerens (metazoa) TA02605 Theileria annulata (apicomplexan parasite) XP_967907.1 Tribolium castaneum (red flour beetle) ENSTNIP00000007026 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000015321 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000036010 Xenopus tropicalis (frog) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB16330 NV17043 LH12211 ISCW018510 FBgn0241901 FBgn0213530 FBgn0210577 FBgn0192284 FBgn0181140 JGI_V11_313838 FBgn0074790 FBgn0159143 FBgn0132958 FBgn0125704 FBgn0109621 FBgn0095447 CPIJ002511 ACYPI004261 GB12702 AGAP004738 AAEL009686 PHUM269260 GLEAN_15452
Stocks & Reagents
Stocks Listed in FlyBase ( 4 )
Bloomington	15965 y1 w67c23; P{EPgy2}CG18005EY06611
VDRC	v103832 P{KK102770}VIE-260B v25289 w1118; P{GD9499}v25289 v25290 w1118; P{GD9499}v25290
Genomic Clones ( 2 )
	BACR08N17 BACR09F04 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 40 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD21347
Other clones	DPiM_LD21347
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT01863 AT20488 AT21956 LD05912 LD07561 LD30790 RE12430 RE16519 RE64693 RH60363 SD23801
Other clones	EK281206 RP003028861 RP003033819 RP003038087 RP003055502 RP003068170 RP003135247 RP003158330 RP003188232 RP003224944 RP003230215 RP003244304 RP003266019 RP003307210 RP003314876 RP003322477 RP003330547 RP003330976 RP003356360 RP003360983 RP003380427 RP003398401 RP003412733 RP003501197 RP003503926 RP003637801 RP003668101
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0037660 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 41091
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_141608 RefSeq (Proteins) • NP_649865 DDBJ / EMBL / GenBank • AA735460 AAF54336 AAL39616 AI455131 AQ073862 AY069471 Entrez Gene - A searchable database of RefSeq genes. • 41091 UniProtKB/TrEMBL • Q9VHH8
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • RED-like, C-terminal (IPR012492) RED-like, N-terminal (IPR012916)
Linkouts
	BioGRID - A database of protein and genetic interactions • 66258 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0037660 DroID - A comprehensive database of gene and protein interactions. • FBgn0037660 DRSC - Results from RNAi screens. • FBgn0037660 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0037660 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG18005-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0037660 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 41091 InParanoid A subset of ortholog calls from InParanoid. • AAEL009686-PA Aedes aegypti (mosquito) AGAP004738-PA Anopheles gambiae (mosquito) XP_394867.2 Apis mellifera (honey bee) XP_001945323.1 Acyrthosiphon pisum (pea aphid) At2g26460.1 Arabidopsis thaliana (wall cress) 90593 Batrachochytrium dendrobatidis (chytrid fungus) 79122 Branchiostoma floridae (lancelet) XP_001902922.1 Brugia malayi (roundworm nematode) ENSBTAP00000020011 Bos taurus (bovine) CN08807 Caenorhabditis brenneri (small nematode) CN16626 Caenorhabditis brenneri (small nematode) CBP10686 Caenorhabditis briggsae (nematode) CE25338 Caenorhabditis elegans (worm) ENSCAFP00000008794 Canis familiaris (dog) ENSCINP00000011595 Ciona intestinalis (sea squirt) cn06082 Cryptococcus neoformans (yeast-like fungus) CPIJ002511 Culex pipens (mosquito) ENSCPOP00000008241 Cavia porcellus (guinea pig) 177943 Chlamidomonas reinhardtii (green alga) RP28079 Caenorhabditis remanei (nematode) ENSCSAVP00000012560 Ciona savignyi (sedentary tunicate) 225605 Capitella spl (polychaete worm) 313838 Daphnia pulex (daphnia) ENSDARP00000009186 Danio rerio (zebra fish) ENSECAP00000011039 Equus caballus (horse) ENSGACP00000027648 Gymnopilus aculeatus (mushroom) ENSGALP00000001219 Gallus gallus (chicken) 88417 Hypsipyla robusta (cedar shoot borer) ENSP00000261812 Homo sapiens (human) ISCW018510-PA Ixodes scapularis (deer tick) 214293 Lottia gigantea (owl limpet) 34240 Monocosta brevicollis (choanoflagellate) ENSMODP00000014297 Monodelphis domestica (gray opossum) ENSMMUP00000013087 Macaca mulatta (rhesus monkey) ENSMUSP00000007042 Mus musculus (house mouse) 211930 Nematostella vectensis (starlet anemone) XP_001603111.1 Nasonia vitripennis (wasp) ENSOANP00000018475 Ornithorynchus anatinus (platypus) ENSORLP00000016298 Oryzias latipes (japanese killifish) LOC_Os11g04950.1 Oryza sativa (asian rice) 32189 Ostreococcus tauri (green alga) PHUM005458-PA Pediculus humanus (human body louse) 197602 Physcomitrella patens (moss) ENSPPYP00000017737 Pongo pygmaeus (orangutan) 75831 Phytophthora ramorum (sudden oak death pathogen) 135360 Phytophthora sojae (root rot pathogen) 778660 Populus trichocarpa (black cottonwood) ENSPTRP00000029615 Pan troglodytes (chimpanzee) PVX_122175 Plasmodium vivax (protozoal parasite) ENSRNOP00000044213 Rattus norvegicus (norway rat) 4765210 Sorghum bicolor (sorghum) Smp_004480 Schistosoma mansoni (trematode parasite) SPBC1539.02 Schizosaccharomyces pombe (fission yeast) XP_001187421.1 Strongylocentrotus purpuratus (purple sea urchin) 64358 Trichoplax adhaerens (metazoa) TA02605 Theileria annulata (apicomplexan parasite) XP_967907.1 Tribolium castaneum (red flour beetle) ENSTNIP00000007026 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000015321 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000036010 Xenopus tropicalis (frog) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 41091 modMine - Data generated by the modENCODE project. • FBgn0037660 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB16330 NV17043 LH12211 ISCW018510 FBgn0241901 FBgn0213530 FBgn0210577 FBgn0192284 FBgn0181140 JGI_V11_313838 FBgn0074790 FBgn0159143 FBgn0132958 FBgn0125704 FBgn0109621 FBgn0095447 CPIJ002511 ACYPI004261 GB12702 AGAP004738 AAEL009686 PHUM269260 GLEAN_15452
Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	CG18005 (Weiler, 2007, Wu et al., 2007, Keleman et al., 2009.8.5, Herold et al., 2009)
Name Synonym
Secondary FlyBase IDs
References ( 13 )
Research paper	Herold et al., 2009, Mol. Cell. Biol. 29(1): 281--301 Conservation of the protein composition and electron microscopy structure of Drosophila melanogaster and human spliceosomal complexes. [FBrf0207172] Weiler, 2007, Genetics 177(1): 167--178 E(var)3-9 of Drosophila melanogaster Encodes a Zinc Finger Protein. [FBrf0201244] Wu et al., 2007, Cell. Microbiol. 9(4): 1073--1085 ird1 is a Vps15 homologue important for antibacterial immune responses in Drosophila. [FBrf0201559] Schulz et al., 2004, Genetics 167(2): 707--723 A misexpression screen reveals effects of bag-of-marbles and TGF beta class signaling on the Drosophila male germ-line stem cell lineage. [FBrf0179436]
Supplementary material	The modENCODE Consortium, 2010, Science 330(6012): DataS14: Gene co-expression clusters. [FBrf0213979] Mummery-Widmer et al., 2009, Nature 458(7241): Supplementary Table 2 - Genome-wide bristle screen results. [FBrf0214518] Giot et al., 2003, Science 302(5651): Tables S1 to S7. [FBrf0166452]
Personal communication to FlyBase	Keleman et al., 2009.8.5, RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0208510] Dickson et al., 2007.7.18, RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0200327] Ryder, 2004.4.26, Exelixis CG deletion data. Exelixis CG deletion data. [FBrf0184335]
Computer file	Gene Disruption Project members, 2001-, [title not yet available] [title not yet available] [FBrf0132177] BDGP Project Members, 2000-, Berkeley Drosophila Genome Project. Berkeley Drosophila Genome Project. [FBrf0125078]