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Gene Dmel\Ada

General Information
Symbol	Dmel\Ada	Species	D. melanogaster
Name	Adenosine deaminase	Annotation symbol	CG11994
Feature type	protein_coding_gene	FlyBase ID	FBgn0037661
Gene Model Status	Current	Stock availability	5 publicly available
Genomic Location
Chromosome (arm)	3R	Recombination map
Cytogenetic map	85C4-85C4	Sequence location	3R:4,890,901..4,892,025 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Adenosine deaminase is referred to in FlyBase by the symbol Dmel\Ada (CG11994, FBgn0037661). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: adenosine deaminase activity. An electronic pipeline based on InterPro domains suggests that it is involved in the biological process: purine ribonucleoside monophosphate biosynthetic process. 4 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: Adenosine/AMP deaminase. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 00-06 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Little or no expression detected in any larval or adult organs/tissues. Comments on Affy2 ProbeSet: ProbeSet 1637806_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of Ada. Gene sequence location is 3R:4890901..4892025.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2011_10
FB2012_01	Sequence features HFA14463 BKN21015
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 85C4-85C4   Limits computationally determined from genome sequence between P{lacW}l(3)L4740L4740 and P{EP}D1EP473
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Ada for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Ada-RA FBtr0081971  NM_141609   1125   337
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Ada-PA   FBpp0081451   37.6   337   5.17     NP_649866   AAF54337
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Adenosine/AMP deaminase (IPR001365)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014297 AAF54337   BF486822   BF497827   BT031009   CO180773   CZ479233   CZ479234   GH740417   GH741324   GH743436   GH744112   GH746046   GH746262   GH764752   GH765444   GH768205   GH768565   GH768606   GH768632   GH769811
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9VHH7
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0037661    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0037661 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 00-06 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0037661 expression level Developmental Stage   Expression Level embryo 00-02hr    886 embryo 02-04hr    1565 embryo 04-06hr    1714 embryo 06-08hr    1392 embryo 08-10hr    1076 embryo 10-12hr    738 embryo 12-14hr    654 embryo 14-16hr    486 embryo 16-18hr    369 embryo 18-20hr    194 embryo 20-22hr    184 embryo 22-24hr    243 larva L1    184 larva L2    228 larva L3 12hr old    228 larva L3 puffstage 1-2    331 larva L3 puffstage 3-6    351 larva L3 puffstage 7-9    438 white prepupae new    407 white prepupae 12hr    424 white prepupae 24hr    405 pupae 2d postWPP    334 pupae 3d postWPP    304 pupae 4d postWPP    231 adult male 01day    423 adult male 05day    476 adult male 30day    431 adult female 01day    312 adult female 05day    536 adult female 30day    622 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (886) embryo 02-04hr  (1565) embryo 04-06hr  (1714) embryo 06-08hr  (1392) embryo 08-10hr  (1076) embryo 10-12hr  (738) embryo 12-14hr  (654) embryo 14-16hr  (486) embryo 16-18hr  (369) embryo 18-20hr  (194) embryo 20-22hr  (184) embryo 22-24hr  (243) larva L1  (184) larva L2  (228) larva L3 12hr old  (228) larva L3 puffstage 1-2  (331) larva L3 puffstage 3-6  (351) larva L3 puffstage 7-9  (438) white prepupae new  (407) white prepupae 12hr  (424) white prepupae 24hr  (405) pupae 2d postWPP  (334) pupae 3d postWPP  (304) pupae 4d postWPP  (231) adult male 01day  (423) adult male 05day  (476) adult male 30day  (431) adult female 01day  (312) adult female 05day  (536) adult female 30day  (622) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    886 embryo 02-04hr  (1565) embryo 04-06hr  (1714) embryo 06-08hr    1392 embryo 08-10hr    1076 embryo 10-12hr    738 embryo 12-14hr    654 embryo 14-16hr    486 embryo 16-18hr    369 embryo 18-20hr    194 embryo 20-22hr    184 embryo 22-24hr    243 larva L1    184 larva L2    228 larva L3 12hr old    228 larva L3 puffstage 1-2    331 larva L3 puffstage 3-6    351 larva L3 puffstage 7-9    438 white prepupae new    407 white prepupae 12hr    424 white prepupae 24hr    405 pupae 2d postWPP    334 pupae 3d postWPP    304 pupae 4d postWPP    231 adult male 01day    423 adult male 05day    476 adult male 30day    431 adult female 01day    312 adult female 05day    536 adult female 30day    622 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    886 embryo 02-04hr    1565 embryo 04-06hr    1714 embryo 06-08hr    1392 embryo 08-10hr    1076 embryo 10-12hr    738 embryo 12-14hr    654 embryo 14-16hr    486 embryo 16-18hr    369 embryo 18-20hr    194 embryo 20-22hr    184 embryo 22-24hr    243 larva L1    184 larva L2    228 larva L3 12hr old    228 larva L3 puffstage 1-2    331 larva L3 puffstage 3-6    351 larva L3 puffstage 7-9    438 white prepupae new    407 white prepupae 12hr    424 white prepupae 24hr    405 pupae 2d postWPP    334 pupae 3d postWPP    304 pupae 4d postWPP    231 adult male 01day    423 adult male 05day    476 adult male 30day    431 adult female 01day    312 adult female 05day    536 adult female 30day    622 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    886 embryo 02-04hr    1565 embryo 04-06hr    1714 embryo 06-08hr    1392 embryo 08-10hr    1076 embryo 10-12hr    738 embryo 12-14hr    654 embryo 14-16hr    486 embryo 16-18hr    369 embryo 18-20hr    194 embryo 20-22hr    184 embryo 22-24hr    243 larva L1    184 larva L2    228 larva L3 12hr old    228 larva L3 puffstage 1-2    331 larva L3 puffstage 3-6    351 larva L3 puffstage 7-9    438 white prepupae new    407 white prepupae 12hr    424 white prepupae 24hr    405 pupae 2d postWPP    334 pupae 3d postWPP    304 pupae 4d postWPP    231 adult male 01day    423 adult male 05day    476 adult male 30day    431 adult female 01day    312 adult female 05day    536 adult female 30day    622 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0037661 expression level Developmental Stage   Expression Level embryo 00-02hr    886 embryo 02-04hr    1565 embryo 04-06hr    1714 embryo 06-08hr    1392 embryo 08-10hr    1076 embryo 10-12hr    738 embryo 12-14hr    654 embryo 14-16hr    486 embryo 16-18hr    369 embryo 18-20hr    194 embryo 20-22hr    184 embryo 22-24hr    243 larva L1    184 larva L2    228 larva L3 12hr old    228 larva L3 puffstage 1-2    331 larva L3 puffstage 3-6    351 larva L3 puffstage 7-9    438 white prepupae new    407 white prepupae 12hr    424 white prepupae 24hr    405 pupae 2d postWPP    334 pupae 3d postWPP    304 pupae 4d postWPP    231 adult male 01day    423 adult male 05day    476 adult male 30day    431 adult female 01day    312 adult female 05day    536 adult female 30day    622 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (886) embryo 02-04hr  (1565) embryo 04-06hr  (1714) embryo 06-08hr  (1392) embryo 08-10hr  (1076) embryo 10-12hr  (738) embryo 12-14hr  (654) embryo 14-16hr  (486) embryo 16-18hr  (369) embryo 18-20hr  (194) embryo 20-22hr  (184) embryo 22-24hr  (243) larva L1  (184) larva L2  (228) larva L3 12hr old  (228) larva L3 puffstage 1-2  (331) larva L3 puffstage 3-6  (351) larva L3 puffstage 7-9  (438) white prepupae new  (407) white prepupae 12hr  (424) white prepupae 24hr  (405) pupae 2d postWPP  (334) pupae 3d postWPP  (304) pupae 4d postWPP  (231) adult male 01day  (423) adult male 05day  (476) adult male 30day  (431) adult female 01day  (312) adult female 05day  (536) adult female 30day  (622) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    886 embryo 02-04hr  1565 embryo 04-06hr  1714 embryo 06-08hr    1392 embryo 08-10hr    1076 embryo 10-12hr    738 embryo 12-14hr    654 embryo 14-16hr    486 embryo 16-18hr    369 embryo 18-20hr    194 embryo 20-22hr    184 embryo 22-24hr    243 larva L1    184 larva L2    228 larva L3 12hr old    228 larva L3 puffstage 1-2    331 larva L3 puffstage 3-6    351 larva L3 puffstage 7-9    438 white prepupae new    407 white prepupae 12hr    424 white prepupae 24hr    405 pupae 2d postWPP    334 pupae 3d postWPP    304 pupae 4d postWPP    231 adult male 01day    423 adult male 05day    476 adult male 30day    431 adult female 01day    312 adult female 05day    536 adult female 30day    622 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    886 embryo 02-04hr    1565 embryo 04-06hr    1714 embryo 06-08hr    1392 embryo 08-10hr    1076 embryo 10-12hr    738 embryo 12-14hr    654 embryo 14-16hr    486 embryo 16-18hr    369 embryo 18-20hr    194 embryo 20-22hr    184 embryo 22-24hr    243 larva L1    184 larva L2    228 larva L3 12hr old    228 larva L3 puffstage 1-2    331 larva L3 puffstage 3-6    351 larva L3 puffstage 7-9    438 white prepupae new    407 white prepupae 12hr    424 white prepupae 24hr    405 pupae 2d postWPP    334 pupae 3d postWPP    304 pupae 4d postWPP    231 adult male 01day    423 adult male 05day    476 adult male 30day    431 adult female 01day    312 adult female 05day    536 adult female 30day    622 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    886 embryo 02-04hr    1565 embryo 04-06hr    1714 embryo 06-08hr    1392 embryo 08-10hr    1076 embryo 10-12hr    738 embryo 12-14hr    654 embryo 14-16hr    486 embryo 16-18hr    369 embryo 18-20hr    194 embryo 20-22hr    184 embryo 22-24hr    243 larva L1    184 larva L2    228 larva L3 12hr old    228 larva L3 puffstage 1-2    331 larva L3 puffstage 3-6    351 larva L3 puffstage 7-9    438 white prepupae new    407 white prepupae 12hr    424 white prepupae 24hr    405 pupae 2d postWPP    334 pupae 3d postWPP    304 pupae 4d postWPP    231 adult male 01day    423 adult male 05day    476 adult male 30day    431 adult female 01day    312 adult female 05day    536 adult female 30day    622 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0037661    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0037661 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Little or no expression detected in any larval or adult organs/tissues. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0037661 expression level Tissue   Expression Level Larval Central Nervous System    28.95 Larval Midgut    7.7 Larval Hindgut no informative data Larval Malpighian Tubules no informative data Larval Fat Body no informative data Larval Salivary Gland    38.6 Larval Trachea    39.425 Larval Carcass    30.8 Adult Head no informative data Adult Eye no informative data Adult Brain    2.6 Adult Thoracic-Abdominal Ganglion    3.1 Adult Crop no informative data Adult Midgut no informative data Adult Hindgut no informative data Adult Malpighian Tubules no informative data Adult Fat Body    24 Adult Salivary Gland no informative data Adult Heart    29.625 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    28.8 Adult Testis    68.5 Adult Male Accessory Gland    30.6 Adult Carcass no informative data Expression Level Scale  None   Low  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    28.95 Larval Midgut    7.7 Larval Hindgut no informative data Larval Malpighian Tubules no informative data Larval Fat Body no informative data Larval Salivary Gland    38.6 Larval Trachea    39.425 Larval Carcass    30.8 Adult Head no informative data Adult Eye no informative data Adult Brain    2.6 Adult Thoracic-Abdominal Ganglion    3.1 Adult Crop no informative data Adult Midgut no informative data Adult Hindgut no informative data Adult Malpighian Tubules no informative data Adult Fat Body    24 Adult Salivary Gland no informative data Adult Heart    29.625 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    28.8 Adult Testis    68.5 Adult Male Accessory Gland    30.6 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    28.95 Larval Midgut    7.7 Larval Hindgut no informative data Larval Malpighian Tubules no informative data Larval Fat Body no informative data Larval Salivary Gland    38.6 Larval Trachea    39.425 Larval Carcass    30.8 Adult Head no informative data Adult Eye no informative data Adult Brain    2.6 Adult Thoracic-Abdominal Ganglion    3.1 Adult Crop no informative data Adult Midgut no informative data Adult Hindgut no informative data Adult Malpighian Tubules no informative data Adult Fat Body    24 Adult Salivary Gland no informative data Adult Heart    29.625 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    28.8 Adult Testis    68.5 Adult Male Accessory Gland    30.6 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    28.95 Larval Midgut    7.7 Larval Hindgut no informative data Larval Malpighian Tubules no informative data Larval Fat Body no informative data Larval Salivary Gland    38.6 Larval Trachea    39.425 Larval Carcass    30.8 Adult Head no informative data Adult Eye no informative data Adult Brain    2.6 Adult Thoracic-Abdominal Ganglion    3.1 Adult Crop no informative data Adult Midgut no informative data Adult Hindgut no informative data Adult Malpighian Tubules no informative data Adult Fat Body    24 Adult Salivary Gland no informative data Adult Heart    29.625 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    28.8 Adult Testis    68.5 Adult Male Accessory Gland    30.6 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0037661 expression level Tissue   Expression Level Larval Central Nervous System    28.95 Larval Midgut    7.7 Larval Hindgut no informative data Larval Malpighian Tubules no informative data Larval Fat Body no informative data Larval Salivary Gland    38.6 Larval Trachea    39.425 Larval Carcass    30.8 Adult Head no informative data Adult Eye no informative data Adult Brain    2.6 Adult Thoracic-Abdominal Ganglion    3.1 Adult Crop no informative data Adult Midgut no informative data Adult Hindgut no informative data Adult Malpighian Tubules no informative data Adult Fat Body    24 Adult Salivary Gland no informative data Adult Heart    29.625 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    28.8 Adult Testis    68.5 Adult Male Accessory Gland    30.6 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    28.95 Larval Midgut    7.7 Larval Hindgut no informative data Larval Malpighian Tubules no informative data Larval Fat Body no informative data Larval Salivary Gland    38.6 Larval Trachea    39.425 Larval Carcass    30.8 Adult Head no informative data Adult Eye no informative data Adult Brain    2.6 Adult Thoracic-Abdominal Ganglion    3.1 Adult Crop no informative data Adult Midgut no informative data Adult Hindgut no informative data Adult Malpighian Tubules no informative data Adult Fat Body    24 Adult Salivary Gland no informative data Adult Heart    29.625 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    28.8 Adult Testis    68.5 Adult Male Accessory Gland    30.6 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    28.95 Larval Midgut    7.7 Larval Hindgut no informative data Larval Malpighian Tubules no informative data Larval Fat Body no informative data Larval Salivary Gland    38.6 Larval Trachea    39.425 Larval Carcass    30.8 Adult Head no informative data Adult Eye no informative data Adult Brain    2.6 Adult Thoracic-Abdominal Ganglion    3.1 Adult Crop no informative data Adult Midgut no informative data Adult Hindgut no informative data Adult Malpighian Tubules no informative data Adult Fat Body    24 Adult Salivary Gland no informative data Adult Heart    29.625 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    28.8 Adult Testis    68.5 Adult Male Accessory Gland    30.6 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    28.95 Larval Midgut    7.7 Larval Hindgut no informative data Larval Malpighian Tubules no informative data Larval Fat Body no informative data Larval Salivary Gland    38.6 Larval Trachea    39.425 Larval Carcass    30.8 Adult Head no informative data Adult Eye no informative data Adult Brain    2.6 Adult Thoracic-Abdominal Ganglion    3.1 Adult Crop no informative data Adult Midgut no informative data Adult Hindgut no informative data Adult Malpighian Tubules no informative data Adult Fat Body    24 Adult Salivary Gland no informative data Adult Heart    29.625 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    28.8 Adult Testis    68.5 Adult Male Accessory Gland    30.6 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut no informative data Larval Malpighian Tubules no informative data Larval Fat Body no informative data Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head no informative data Adult Eye no informative data Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop no informative data Adult Midgut no informative data Adult Hindgut no informative data Adult Malpighian Tubules no informative data Adult Fat Body     Adult Salivary Gland no informative data Adult Heart     Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass no informative data FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    no informative data   NA  Eye    no informative data   NA  Brain    2.6   28.95  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    3.1   NA  Crop    no informative data   7.7  Midgut    no informative data   no informative data  Hindgut    no informative data   no informative data  Malpighian Tubules    no informative data   no informative data  Fat Body    24   38.6  Salivary Gland    no informative data   NA  Heart    29.625   39.425  Trachea    NA   NA  VirginFemale Spermatheca    no informative data   NA  InseminatedFemale Spermatheca    no informative data   NA  Ovary    28.8   NA  Testis    68.5   NA  Male Accessory Gland    30.6   30.8  Carcass    no informative data modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_30
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0037661 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG11994-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable, with Scer\GAL4pnr-MD237 AdaGD7455 Phenotype manifest in Allele
Classical Alleles ( 1 )
For All Classical Alleles Show
Allele of Ada Class Mutagen Stocks Known lesion Adae01422 piggyBac transposase 1 --
Alleles Carried on Transgenic Constructs ( 3 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Ada Class Mutagen Stocks Known lesion AdaGD7455 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes AdaJF02040 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes AdaKK100919 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes
Aneuploid Aberrations
Disrupted in	Df(3R)Exel6151 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD7455} NA P{KK100919} NA P{TRiP.JF02040} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions PBac{RB}Adae01422 NA
Gene Ontology: Function, Process & Cellular Component ( 2 unique terms )
	There is no information supporting a cellular component term for this gene. (Based on a review of available data before: 2006)
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 2 terms )
Molecular Function
CV term Evidence References
adenosine deaminase activity inferred from sequence or structural similarity with mouse Ada (FlyBase, 1992-)
Biological Process
CV term Evidence References
purine ribonucleoside monophosphate biosynthetic process inferred from electronic annotation with InterPro:IPR001365 (FlyBase Curators et al., 2004-)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Ada allele Gene References
External Data
Linkouts	DPiM - DPiM, Drosophila Protein interaction Map • FBgn0037661 DroID - A comprehensive database of gene and protein interactions. • FBgn0037661
Orthologs
Genome-wide drosophilid orthologs	Dana\GF16581 Dere\GG15092 Dgri\GH19347 Dmoj\GI22557 Dper\GL22286 Dpse\GA11319 Dsec\GM23784 Dsim\GD18595 Dvir\GJ23746 Dwil\GK11584 Dyak\GE25929
Curated drosophilid orthologs	Dpse\GA11319
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL009191-PA Aedes aegypti (mosquito) AGAP005158-PA Anopheles gambiae (mosquito) XP_394309.3 Apis mellifera (honey bee) At4g04880.1 Arabidopsis thaliana (wall cress) 20019 Batrachochytrium dendrobatidis (chytrid fungus) 107703 Branchiostoma floridae (lancelet) XP_001895175.1 Brugia malayi (roundworm nematode) BGIBMGA001278-PA Bombyx mori (silk worm) ENSBTAP00000019248 Bos taurus (bovine) CAL0006286 Candida albicans (a form of yeast) CN24618 Caenorhabditis brenneri (small nematode) CN26510 Caenorhabditis brenneri (small nematode) CBP07273 Caenorhabditis briggsae (nematode) CE39336 Caenorhabditis elegans (worm) ENSCAFP00000017729 Canis familiaris (dog) CAGL0J05984g Candida glabrata (haploid yeast) ENSCINP00000004062 Ciona intestinalis (sea squirt) JA13904 Caenorhabditis japonica (nematode) CPIJ014249 Culex pipens (mosquito) ENSCPOP00000002123 Cavia porcellus (guinea pig) 175699 Chlamidomonas reinhardtii (green alga) RP01651 Caenorhabditis remanei (nematode) ENSCSAVP00000008261 Ciona savignyi (sedentary tunicate) 219075 Capitella spl (polychaete worm) 322499 Daphnia pulex (daphnia) ENSDARP00000017525 Danio rerio (zebra fish) ENSDARP00000067287 Danio rerio (zebra fish) ENSECAP00000012205 Equus caballus (horse) NP_416140.1 Escherichia coli K12 (bacteria) XP_652836 Entamoeba histolytica (anaerobic protozoan) ENSGACP00000012965 Gymnopilus aculeatus (mushroom) ENSGALP00000006420 Gallus gallus (chicken) 110129 Hypsipyla robusta (cedar shoot borer) ENSP00000374302 Homo sapiens (human) ISCW005182-PA Ixodes scapularis (deer tick) KLLA0E23167g Kluyveromyces lactis (yeast) 178823 Lottia gigantea (owl limpet) LmjF10.0840 Leishmania major (virus) ENSMODP00000022221 Monodelphis domestica (gray opossum) ENSMMUP00000022466 Macaca mulatta (rhesus monkey) ENSMUSP00000113052 Mus musculus (house mouse) 240431 Nematostella vectensis (starlet anemone) XP_001600021.1 Nasonia vitripennis (wasp) ENSORLP00000006105 Oryzias latipes (japanese killifish) LOC_Os07g46630.1 Oryza sativa (asian rice) PHUM004805-PA Pediculus humanus (human body louse) PP02800 Pristionchus pacificus (nematode) 195414 Physcomitrella patens (moss) ENSPPYP00000007264 Pongo pygmaeus (orangutan) 81435 Phytophthora ramorum (sudden oak death pathogen) 134850 Phytophthora sojae (root rot pathogen) 837657 Populus trichocarpa (black cottonwood) ENSPTRP00000011943 Pan troglodytes (chimpanzee) PVX_111245 Plasmodium vivax (protozoal parasite) ENSRNOP00000016529 Rattus norvegicus (norway rat) 5034799 Sorghum bicolor (sorghum) YNL141W Saccharomyces cerevisiae (budding yeast) Smp_140430 Schistosoma mansoni (trematode parasite) SPBC1683.02 Schizosaccharomyces pombe (fission yeast) XP_794004.2 Strongylocentrotus purpuratus (purple sea urchin) 61081 Trichoplax adhaerens (metazoa) XP_969051.2 Tribolium castaneum (red flour beetle) Tc00.1047053508987.39 Trypanosoma cruzi (parasitic trypanosome) Tc00.1047053509567.34 Trypanosoma cruzi (parasitic trypanosome) ENSTNIP00000003963 Tetraodon nigroviridis (green spotted pufferfish) 37724 Thalassiosira pseudonana (marine diatom) ENSTRUP00000043740 Takifugu rubripes (pufferfish Takifugu) 3680.m00114 Tetrahymena thermophila (ciliate protozoa) ENSXETP00000043874 Xenopus tropicalis (frog) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB12948 NV17631 LH12413 FBgn0242978 FBgn0213595 FBgn0210843 FBgn0190117 FBgn0178649 JGI_V11_322499 FBgn0071373 FBgn0159878 FBgn0145285 FBgn0126812 FBgn0107346 FBgn0093602 CPIJ014249 BGIBMGA001278 GB13463 AGAP005158 AAEL015233 AAEL009191 PHUM377770 GLEAN_10107
Stocks & Reagents
Stocks Listed in FlyBase ( 5 )
Bloomington	26015 y1 v1; P{TRiP.JF02040}attP2
Harvard	- PBac{RB}Adae01422
VDRC	v105631 P{KK100919}VIE-260B v18719 w1118; P{GD7455}v18719 v18720 w1118; P{GD7455}v18720
Genomic Clones ( 2 )
	BACR08N17 BACR09F04 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 18 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	RE18358
Other clones	DPiM_RE18358
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT12127 AT21359
Other clones	EC06096 RP001003096 RP001017283 RP001017913 RP001022181 RP001025912 RP001039943 RP001041287 RP001042885 RP001043898 RP001043932 RP001051205 RP001051684 RP001054972
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0037661 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 41092
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_141609 RefSeq (Proteins) • NP_649866 DDBJ / EMBL / GenBank • AAF54337 BF497827 CZ479233 CZ479234 Entrez Gene - A searchable database of RefSeq genes. • 41092 UniProtKB/TrEMBL • Q9VHH7
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Adenosine/AMP deaminase (IPR001365)
Linkouts
	DPiM - DPiM, Drosophila Protein interaction Map • FBgn0037661 DroID - A comprehensive database of gene and protein interactions. • FBgn0037661 DRSC - Results from RNAi screens. • FBgn0037661 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0037661 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG11994-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0037661 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 41092 InParanoid A subset of ortholog calls from InParanoid. • AAEL009191-PA Aedes aegypti (mosquito) AGAP005158-PA Anopheles gambiae (mosquito) XP_394309.3 Apis mellifera (honey bee) At4g04880.1 Arabidopsis thaliana (wall cress) 20019 Batrachochytrium dendrobatidis (chytrid fungus) 107703 Branchiostoma floridae (lancelet) XP_001895175.1 Brugia malayi (roundworm nematode) BGIBMGA001278-PA Bombyx mori (silk worm) ENSBTAP00000019248 Bos taurus (bovine) CAL0006286 Candida albicans (a form of yeast) CN24618 Caenorhabditis brenneri (small nematode) CN26510 Caenorhabditis brenneri (small nematode) CBP07273 Caenorhabditis briggsae (nematode) CE39336 Caenorhabditis elegans (worm) ENSCAFP00000017729 Canis familiaris (dog) CAGL0J05984g Candida glabrata (haploid yeast) ENSCINP00000004062 Ciona intestinalis (sea squirt) JA13904 Caenorhabditis japonica (nematode) CPIJ014249 Culex pipens (mosquito) ENSCPOP00000002123 Cavia porcellus (guinea pig) 175699 Chlamidomonas reinhardtii (green alga) RP01651 Caenorhabditis remanei (nematode) ENSCSAVP00000008261 Ciona savignyi (sedentary tunicate) 219075 Capitella spl (polychaete worm) 322499 Daphnia pulex (daphnia) ENSDARP00000017525 Danio rerio (zebra fish) ENSDARP00000067287 Danio rerio (zebra fish) ENSECAP00000012205 Equus caballus (horse) NP_416140.1 Escherichia coli K12 (bacteria) XP_652836 Entamoeba histolytica (anaerobic protozoan) ENSGACP00000012965 Gymnopilus aculeatus (mushroom) ENSGALP00000006420 Gallus gallus (chicken) 110129 Hypsipyla robusta (cedar shoot borer) ENSP00000374302 Homo sapiens (human) ISCW005182-PA Ixodes scapularis (deer tick) KLLA0E23167g Kluyveromyces lactis (yeast) 178823 Lottia gigantea (owl limpet) LmjF10.0840 Leishmania major (virus) ENSMODP00000022221 Monodelphis domestica (gray opossum) ENSMMUP00000022466 Macaca mulatta (rhesus monkey) ENSMUSP00000113052 Mus musculus (house mouse) 240431 Nematostella vectensis (starlet anemone) XP_001600021.1 Nasonia vitripennis (wasp) ENSORLP00000006105 Oryzias latipes (japanese killifish) LOC_Os07g46630.1 Oryza sativa (asian rice) PHUM004805-PA Pediculus humanus (human body louse) PP02800 Pristionchus pacificus (nematode) 195414 Physcomitrella patens (moss) ENSPPYP00000007264 Pongo pygmaeus (orangutan) 81435 Phytophthora ramorum (sudden oak death pathogen) 134850 Phytophthora sojae (root rot pathogen) 837657 Populus trichocarpa (black cottonwood) ENSPTRP00000011943 Pan troglodytes (chimpanzee) PVX_111245 Plasmodium vivax (protozoal parasite) ENSRNOP00000016529 Rattus norvegicus (norway rat) 5034799 Sorghum bicolor (sorghum) YNL141W Saccharomyces cerevisiae (budding yeast) Smp_140430 Schistosoma mansoni (trematode parasite) SPBC1683.02 Schizosaccharomyces pombe (fission yeast) XP_794004.2 Strongylocentrotus purpuratus (purple sea urchin) 61081 Trichoplax adhaerens (metazoa) XP_969051.2 Tribolium castaneum (red flour beetle) Tc00.1047053508987.39 Trypanosoma cruzi (parasitic trypanosome) Tc00.1047053509567.34 Trypanosoma cruzi (parasitic trypanosome) ENSTNIP00000003963 Tetraodon nigroviridis (green spotted pufferfish) 37724 Thalassiosira pseudonana (marine diatom) ENSTRUP00000043740 Takifugu rubripes (pufferfish Takifugu) 3680.m00114 Tetrahymena thermophila (ciliate protozoa) ENSXETP00000043874 Xenopus tropicalis (frog) modMine - Data generated by the modENCODE project. • FBgn0037661 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB12948 NV17631 LH12413 FBgn0242978 FBgn0213595 FBgn0210843 FBgn0190117 FBgn0178649 JGI_V11_322499 FBgn0071373 FBgn0159878 FBgn0145285 FBgn0126812 FBgn0107346 FBgn0093602 CPIJ014249 BGIBMGA001278 GB13463 AGAP005158 AAEL015233 AAEL009191 PHUM377770 GLEAN_10107
Synonyms & Secondary IDs ( 7 )
Reported As
Symbol Synonym	ADA (Zurovec et al., 2002) Ada (Weiler, 2007) CG11994 (Zurovec et al., 2002, Perkins et al., 1.15.2009, Wu et al., 2007, Keleman et al., 2009.8.5) dADA (Pospech et al., 2005) DrosADA (Maier et al., 2001) unnamed (Charlab et al., 2001)
Name Synonym	Adenosine deaminase (Maier et al., 2001)
Secondary FlyBase IDs
References ( 22 )
Generate a list of	All references relating to this gene ( 22 )
List References by type	Research paper  ( 6 ) Supplementary material  ( 2 ) Personal communication to FlyBase  ( 5 ) Abstract  ( 1 ) FlyBase analysis  ( 2 ) Computer file  ( 3 ) Automatic genome annotation  ( 1 ) Curated genome annotation  ( 1 )
Recent research papers (0)
	All research papers listed in FlyBase were published before 2010 Show research papers ...