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Gene Dmel\bocksbeutel

General Information
Symbol	Dmel\bocksbeutel	Species	D. melanogaster
Name	bocksbeutel	Annotation symbol	CG9424
Feature type	protein_coding_gene	FlyBase ID	FBgn0037719
Gene Model Status	Current	Stock availability	3 publicly available
Genomic Location
Chromosome (arm)	3R	Recombination map
Cytogenetic map	85D27-85D27	Sequence location	3R:5,415,190..5,416,709 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene bocksbeutel is referred to in FlyBase by the symbol Dmel\bocksbeutel (CG9424, FBgn0037719). It is a protein_coding_gene from Drosophila melanogaster. Its molecular function is unknown. The biological processes in which it is involved are not known. 4 alleles are reported. No phenotypic data is available. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: LEM-like domain; Lamino-associated polypeptide 2/emerin. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-06 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval Malpighian tubules, adult heart, larval/adult fat body, larval salivary gland, larval trachea, adult ovary, adult male accessory gland, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1639882_at completely aligns to an exonic region common to each of the 2 FlyBase-annotated transcript isoforms of bocksbeutel. Gene sequence location is 3R:5415190..5416709.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2011_10
FB2012_01	Sequence features BKN30092 HFA16489
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 85D27-85D27   Limits computationally determined from genome sequence between P{EP}CG9393EP3122 and P{EP}CrcEP3006
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\bocksbeutel for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) bocksbeutel-RA FBtr0082105  NM_141660   1420   351 bocksbeutel-RB FBtr0100537  NM_001014611   1520   399
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein bocksbeutel-PA   FBpp0099981   38.8   351   9.29     NP_649917   AAF54412 bocksbeutel-PB   FBpp0099982   44.2   399   9.58     NP_001014611   AAX52941
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Lamino-associated polypeptide 2/emerin (IPR003887) LEM-like domain (IPR011015)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014297 AAF54412   AE014297 AAX52941   AI064518   AI513462   AI531338   AJ606681 CAE54810   AJ606682 CAE54811   AW943801   AY069685 AAL39830   BI141947   BI170310   BI355696   CO270959   CO312498   CO325664   CO327964   CO331684   CO337350   EC077470   EC223936   EC240414   EC248143   EC256584   EC266988   EV574773   GH757340   GH758902   GH759931   GH760884   GH778501   GH781188   GH781933   GH782952   GH783300   GH783311   GH783493   GH786595   GH789671   GH789738   GH790149   GH799356   GH811448   GH815292   GH818269   GH820515   GH821586   GH825484   GH836598   GH838385   GH840694   GH843814   GH845499   GH846763   GH851464   GH854720   GH857765   GH858910   GH861531   GH868847   GH869378   GH876031   GH876434   GH879502   GH880502   GH880732   GH895635   GH896631   GH898744   GH912239   GH912441   GH917196   GH918790   GH919719   GH928678   GH933041   GH935962   GH937931   GH942424
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q709R6 Q9VHA7
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0037719    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0037719 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-06 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0037719 expression level Developmental Stage   Expression Level embryo 00-02hr    3069 embryo 02-04hr    2749 embryo 04-06hr    4056 embryo 06-08hr    2874 embryo 08-10hr    2299 embryo 10-12hr    1827 embryo 12-14hr    1483 embryo 14-16hr    1212 embryo 16-18hr    1145 embryo 18-20hr    1283 embryo 20-22hr    1426 embryo 22-24hr    1538 larva L1    1311 larva L2    1150 larva L3 12hr old    922 larva L3 puffstage 1-2    1126 larva L3 puffstage 3-6    1657 larva L3 puffstage 7-9    2196 white prepupae new    2333 white prepupae 12hr    1439 white prepupae 24hr    1407 pupae 2d postWPP    1188 pupae 3d postWPP    659 pupae 4d postWPP    660 adult male 01day    859 adult male 05day    978 adult male 30day    951 adult female 01day    1400 adult female 05day    2079 adult female 30day    2005 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (3069) embryo 02-04hr  (2749) embryo 04-06hr  (4056) embryo 06-08hr  (2874) embryo 08-10hr  (2299) embryo 10-12hr  (1827) embryo 12-14hr  (1483) embryo 14-16hr  (1212) embryo 16-18hr  (1145) embryo 18-20hr  (1283) embryo 20-22hr  (1426) embryo 22-24hr  (1538) larva L1  (1311) larva L2  (1150) larva L3 12hr old  (922) larva L3 puffstage 1-2  (1126) larva L3 puffstage 3-6  (1657) larva L3 puffstage 7-9  (2196) white prepupae new  (2333) white prepupae 12hr  (1439) white prepupae 24hr  (1407) pupae 2d postWPP  (1188) pupae 3d postWPP  (659) pupae 4d postWPP  (660) adult male 01day  (859) adult male 05day  (978) adult male 30day  (951) adult female 01day  (1400) adult female 05day  (2079) adult female 30day  (2005) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (3069) embryo 02-04hr  (2749) embryo 04-06hr  (4056) embryo 06-08hr  (2874) embryo 08-10hr  (2299) embryo 10-12hr  (1827) embryo 12-14hr  1483 embryo 14-16hr    1212 embryo 16-18hr    1145 embryo 18-20hr    1283 embryo 20-22hr  1426 embryo 22-24hr  (1538) larva L1    1311 larva L2    1150 larva L3 12hr old    922 larva L3 puffstage 1-2    1126 larva L3 puffstage 3-6  (1657) larva L3 puffstage 7-9  (2196) white prepupae new  (2333) white prepupae 12hr  1439 white prepupae 24hr  1407 pupae 2d postWPP    1188 pupae 3d postWPP    659 pupae 4d postWPP    660 adult male 01day    859 adult male 05day    978 adult male 30day    951 adult female 01day    1400 adult female 05day  (2079) adult female 30day  (2005) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    3069 embryo 02-04hr    2749 embryo 04-06hr    4056 embryo 06-08hr    2874 embryo 08-10hr    2299 embryo 10-12hr    1827 embryo 12-14hr    1483 embryo 14-16hr    1212 embryo 16-18hr    1145 embryo 18-20hr    1283 embryo 20-22hr    1426 embryo 22-24hr    1538 larva L1    1311 larva L2    1150 larva L3 12hr old    922 larva L3 puffstage 1-2    1126 larva L3 puffstage 3-6    1657 larva L3 puffstage 7-9    2196 white prepupae new    2333 white prepupae 12hr    1439 white prepupae 24hr    1407 pupae 2d postWPP    1188 pupae 3d postWPP    659 pupae 4d postWPP    660 adult male 01day    859 adult male 05day    978 adult male 30day    951 adult female 01day    1400 adult female 05day    2079 adult female 30day    2005 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    3069 embryo 02-04hr    2749 embryo 04-06hr    4056 embryo 06-08hr    2874 embryo 08-10hr    2299 embryo 10-12hr    1827 embryo 12-14hr    1483 embryo 14-16hr    1212 embryo 16-18hr    1145 embryo 18-20hr    1283 embryo 20-22hr    1426 embryo 22-24hr    1538 larva L1    1311 larva L2    1150 larva L3 12hr old    922 larva L3 puffstage 1-2    1126 larva L3 puffstage 3-6    1657 larva L3 puffstage 7-9    2196 white prepupae new    2333 white prepupae 12hr    1439 white prepupae 24hr    1407 pupae 2d postWPP    1188 pupae 3d postWPP    659 pupae 4d postWPP    660 adult male 01day    859 adult male 05day    978 adult male 30day    951 adult female 01day    1400 adult female 05day    2079 adult female 30day    2005 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0037719 expression level Developmental Stage   Expression Level embryo 00-02hr    3069 embryo 02-04hr    2749 embryo 04-06hr    4056 embryo 06-08hr    2874 embryo 08-10hr    2299 embryo 10-12hr    1827 embryo 12-14hr    1483 embryo 14-16hr    1212 embryo 16-18hr    1145 embryo 18-20hr    1283 embryo 20-22hr    1426 embryo 22-24hr    1538 larva L1    1311 larva L2    1150 larva L3 12hr old    922 larva L3 puffstage 1-2    1126 larva L3 puffstage 3-6    1657 larva L3 puffstage 7-9    2196 white prepupae new    2333 white prepupae 12hr    1439 white prepupae 24hr    1407 pupae 2d postWPP    1188 pupae 3d postWPP    659 pupae 4d postWPP    660 adult male 01day    859 adult male 05day    978 adult male 30day    951 adult female 01day    1400 adult female 05day    2079 adult female 30day    2005 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (3069) embryo 02-04hr  (2749) embryo 04-06hr  (4056) embryo 06-08hr  (2874) embryo 08-10hr  (2299) embryo 10-12hr  (1827) embryo 12-14hr  (1483) embryo 14-16hr  (1212) embryo 16-18hr  (1145) embryo 18-20hr  (1283) embryo 20-22hr  (1426) embryo 22-24hr  (1538) larva L1  (1311) larva L2  (1150) larva L3 12hr old  (922) larva L3 puffstage 1-2  (1126) larva L3 puffstage 3-6  (1657) larva L3 puffstage 7-9  (2196) white prepupae new  (2333) white prepupae 12hr  (1439) white prepupae 24hr  (1407) pupae 2d postWPP  (1188) pupae 3d postWPP  (659) pupae 4d postWPP  (660) adult male 01day  (859) adult male 05day  (978) adult male 30day  (951) adult female 01day  (1400) adult female 05day  (2079) adult female 30day  (2005) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (3069) embryo 02-04hr  (2749) embryo 04-06hr  (4056) embryo 06-08hr  (2874) embryo 08-10hr  2299 embryo 10-12hr  1827 embryo 12-14hr  1483 embryo 14-16hr    1212 embryo 16-18hr    1145 embryo 18-20hr    1283 embryo 20-22hr  1426 embryo 22-24hr  1538 larva L1    1311 larva L2    1150 larva L3 12hr old    922 larva L3 puffstage 1-2    1126 larva L3 puffstage 3-6  1657 larva L3 puffstage 7-9  2196 white prepupae new  2333 white prepupae 12hr  1439 white prepupae 24hr  1407 pupae 2d postWPP    1188 pupae 3d postWPP    659 pupae 4d postWPP    660 adult male 01day    859 adult male 05day    978 adult male 30day    951 adult female 01day  1400 adult female 05day  2079 adult female 30day  2005 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    3069 embryo 02-04hr    2749 embryo 04-06hr    4056 embryo 06-08hr    2874 embryo 08-10hr    2299 embryo 10-12hr    1827 embryo 12-14hr    1483 embryo 14-16hr    1212 embryo 16-18hr    1145 embryo 18-20hr    1283 embryo 20-22hr    1426 embryo 22-24hr    1538 larva L1    1311 larva L2    1150 larva L3 12hr old    922 larva L3 puffstage 1-2    1126 larva L3 puffstage 3-6    1657 larva L3 puffstage 7-9    2196 white prepupae new    2333 white prepupae 12hr    1439 white prepupae 24hr    1407 pupae 2d postWPP    1188 pupae 3d postWPP    659 pupae 4d postWPP    660 adult male 01day    859 adult male 05day    978 adult male 30day    951 adult female 01day    1400 adult female 05day    2079 adult female 30day    2005 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    3069 embryo 02-04hr    2749 embryo 04-06hr    4056 embryo 06-08hr    2874 embryo 08-10hr    2299 embryo 10-12hr    1827 embryo 12-14hr    1483 embryo 14-16hr    1212 embryo 16-18hr    1145 embryo 18-20hr    1283 embryo 20-22hr    1426 embryo 22-24hr    1538 larva L1    1311 larva L2    1150 larva L3 12hr old    922 larva L3 puffstage 1-2    1126 larva L3 puffstage 3-6    1657 larva L3 puffstage 7-9    2196 white prepupae new    2333 white prepupae 12hr    1439 white prepupae 24hr    1407 pupae 2d postWPP    1188 pupae 3d postWPP    659 pupae 4d postWPP    660 adult male 01day    859 adult male 05day    978 adult male 30day    951 adult female 01day    1400 adult female 05day    2079 adult female 30day    2005 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0037719    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0037719 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval Malpighian tubules, adult heart, larval/adult fat body, larval salivary gland, larval trachea, adult ovary, adult male accessory gland, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0037719 expression level Tissue   Expression Level Larval Central Nervous System    124.15 Larval Midgut    162.1 Larval Hindgut    218.9 Larval Malpighian Tubules    224.8 Larval Fat Body    111.6 Larval Salivary Gland    170.7 Larval Trachea    154.825 Larval Carcass    144.9 Adult Head    86.3 Adult Eye    94.175 Adult Brain    91.5 Adult Thoracic-Abdominal Ganglion    89.1 Adult Crop    149.7 Adult Midgut    114.4 Adult Hindgut    166.3 Adult Malpighian Tubules    89.2 Adult Fat Body    129.7 Adult Salivary Gland    90.3 Adult Heart    137.5 Adult VirginFemale Spermatheca    76.6 Adult InseminatedFemale Spermatheca    95.1 Adult Ovary    196.8 Adult Testis    64.8 Adult Male Accessory Gland    135.5 Adult Carcass    104.3 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    124.15 Larval Midgut    162.1 Larval Hindgut    218.9 Larval Malpighian Tubules    224.8 Larval Fat Body    111.6 Larval Salivary Gland    170.7 Larval Trachea    154.825 Larval Carcass    144.9 Adult Head    86.3 Adult Eye    94.175 Adult Brain    91.5 Adult Thoracic-Abdominal Ganglion    89.1 Adult Crop    149.7 Adult Midgut    114.4 Adult Hindgut    166.3 Adult Malpighian Tubules    89.2 Adult Fat Body    129.7 Adult Salivary Gland    90.3 Adult Heart    137.5 Adult VirginFemale Spermatheca    76.6 Adult InseminatedFemale Spermatheca    95.1 Adult Ovary    196.8 Adult Testis    64.8 Adult Male Accessory Gland    135.5 Adult Carcass    104.3 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    124.15 Larval Midgut    162.1 Larval Hindgut    218.9 Larval Malpighian Tubules    224.8 Larval Fat Body    111.6 Larval Salivary Gland    170.7 Larval Trachea    154.825 Larval Carcass    144.9 Adult Head    86.3 Adult Eye    94.175 Adult Brain    91.5 Adult Thoracic-Abdominal Ganglion    89.1 Adult Crop    149.7 Adult Midgut    114.4 Adult Hindgut    166.3 Adult Malpighian Tubules    89.2 Adult Fat Body    129.7 Adult Salivary Gland    90.3 Adult Heart    137.5 Adult VirginFemale Spermatheca    76.6 Adult InseminatedFemale Spermatheca    95.1 Adult Ovary    196.8 Adult Testis    64.8 Adult Male Accessory Gland    135.5 Adult Carcass    104.3 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    124.15 Larval Midgut    162.1 Larval Hindgut    218.9 Larval Malpighian Tubules    224.8 Larval Fat Body    111.6 Larval Salivary Gland    170.7 Larval Trachea    154.825 Larval Carcass    144.9 Adult Head    86.3 Adult Eye    94.175 Adult Brain    91.5 Adult Thoracic-Abdominal Ganglion    89.1 Adult Crop    149.7 Adult Midgut    114.4 Adult Hindgut    166.3 Adult Malpighian Tubules    89.2 Adult Fat Body    129.7 Adult Salivary Gland    90.3 Adult Heart    137.5 Adult VirginFemale Spermatheca    76.6 Adult InseminatedFemale Spermatheca    95.1 Adult Ovary    196.8 Adult Testis    64.8 Adult Male Accessory Gland    135.5 Adult Carcass    104.3 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0037719 expression level Tissue   Expression Level Larval Central Nervous System    124.15 Larval Midgut    162.1 Larval Hindgut    218.9 Larval Malpighian Tubules    224.8 Larval Fat Body    111.6 Larval Salivary Gland    170.7 Larval Trachea    154.825 Larval Carcass    144.9 Adult Head    86.3 Adult Eye    94.175 Adult Brain    91.5 Adult Thoracic-Abdominal Ganglion    89.1 Adult Crop    149.7 Adult Midgut    114.4 Adult Hindgut    166.3 Adult Malpighian Tubules    89.2 Adult Fat Body    129.7 Adult Salivary Gland    90.3 Adult Heart    137.5 Adult VirginFemale Spermatheca    76.6 Adult InseminatedFemale Spermatheca    95.1 Adult Ovary    196.8 Adult Testis    64.8 Adult Male Accessory Gland    135.5 Adult Carcass    104.3 Expression Level Scale  None   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    124.15 Larval Midgut    162.1 Larval Hindgut    218.9 Larval Malpighian Tubules    224.8 Larval Fat Body    111.6 Larval Salivary Gland    170.7 Larval Trachea    154.825 Larval Carcass    144.9 Adult Head    86.3 Adult Eye    94.175 Adult Brain    91.5 Adult Thoracic-Abdominal Ganglion    89.1 Adult Crop    149.7 Adult Midgut    114.4 Adult Hindgut    166.3 Adult Malpighian Tubules    89.2 Adult Fat Body    129.7 Adult Salivary Gland    90.3 Adult Heart    137.5 Adult VirginFemale Spermatheca    76.6 Adult InseminatedFemale Spermatheca    95.1 Adult Ovary    196.8 Adult Testis    64.8 Adult Male Accessory Gland    135.5 Adult Carcass    104.3 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    124.15 Larval Midgut    162.1 Larval Hindgut    218.9 Larval Malpighian Tubules    224.8 Larval Fat Body    111.6 Larval Salivary Gland    170.7 Larval Trachea    154.825 Larval Carcass    144.9 Adult Head    86.3 Adult Eye    94.175 Adult Brain    91.5 Adult Thoracic-Abdominal Ganglion    89.1 Adult Crop    149.7 Adult Midgut    114.4 Adult Hindgut    166.3 Adult Malpighian Tubules    89.2 Adult Fat Body    129.7 Adult Salivary Gland    90.3 Adult Heart    137.5 Adult VirginFemale Spermatheca    76.6 Adult InseminatedFemale Spermatheca    95.1 Adult Ovary    196.8 Adult Testis    64.8 Adult Male Accessory Gland    135.5 Adult Carcass    104.3 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    124.15 Larval Midgut    162.1 Larval Hindgut    218.9 Larval Malpighian Tubules    224.8 Larval Fat Body    111.6 Larval Salivary Gland    170.7 Larval Trachea    154.825 Larval Carcass    144.9 Adult Head    86.3 Adult Eye    94.175 Adult Brain    91.5 Adult Thoracic-Abdominal Ganglion    89.1 Adult Crop    149.7 Adult Midgut    114.4 Adult Hindgut    166.3 Adult Malpighian Tubules    89.2 Adult Fat Body    129.7 Adult Salivary Gland    90.3 Adult Heart    137.5 Adult VirginFemale Spermatheca    76.6 Adult InseminatedFemale Spermatheca    95.1 Adult Ovary    196.8 Adult Testis    64.8 Adult Male Accessory Gland    135.5 Adult Carcass    104.3 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    86.3   NA  Eye    94.175   NA  Brain    91.5   124.15  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    89.1   NA  Crop    149.7   162.1  Midgut    114.4   218.9  Hindgut    166.3   224.8  Malpighian Tubules    89.2   111.6  Fat Body    129.7   170.7  Salivary Gland    90.3   NA  Heart    137.5   154.825  Trachea    NA   NA  VirginFemale Spermatheca    76.6   NA  InseminatedFemale Spermatheca    95.1   NA  Ovary    196.8   NA  Testis    64.8   NA  Male Accessory Gland    135.5   144.9  Carcass    104.3 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_05
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0037719 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG9424-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable bocksbeutelCB03586 viable, with Scer\GAL4pnr-MD237 bocksbeutelGD13812 Phenotype manifest in Allele
Classical Alleles ( 2 )
For All Classical Alleles Show
Allele of bocksbeutel Class Mutagen Stocks Known lesion bocksbeutelDP01391 1 -- bocksbeutelCB03586 P-element activity 0 Yes
Alleles Carried on Transgenic Constructs ( 2 )
For All Alleles Carried on Transgenic Constructs Show
Allele of bocksbeutel Class Mutagen Stocks Known lesion bocksbeutelGD13812 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes bocksbeutelhs.PS in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3R)Exel6153 (Ryder, 2004.4.26) Df(3R)Exel6264 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data heat-shock construct P{hs-bocksbeutel.S} NA UAS construct P{GD13812} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{Mae-UAS.6.11}bocksbeutelDP01391 NA miscellaneous insertions P{PTT-GB}bocksbeutelCB03586 NA
Gene Ontology: Function, Process & Cellular Component ( 1 unique term )
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 1 term )
Molecular Function ( 0 terms)
Biological Process ( 0 terms)
Cellular Component
CV term Evidence References
nuclear envelope inferred from electronic annotation with InterPro:IPR003887 (FlyBase Curators et al., 2004-)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions bocksbeutel allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 66321 DroID - A comprehensive database of gene and protein interactions. • FBgn0037719 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 41162
Orthologs
Genome-wide drosophilid orthologs	Dana\GF16530 Dere\GG17352 Dgri\GH19297 Dmoj\GI23513 Dper\GL22173 Dpse\GA21776 Dsec\GM26238 Dsim\GD20779 Dvir\GJ10265 Dwil\GK12790 Dyak\GE24758
Curated drosophilid orthologs	Dpse\GA21776
Linkouts	OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • FBgn0241861 FBgn0214799 FBgn0197551 FBgn0192243 FBgn0181093 FBgn0249214 FBgn0249213 FBgn0244600 FBgn0081761 FBgn0159765 FBgn0154316 FBgn0146239 FBgn0126763 FBgn0109579 FBgn0093551 CPIJ000243 GB17890 AGAP007603 AAEL001580
Stocks & Reagents
Stocks Listed in FlyBase ( 3 )
Bloomington	21846 y1 w67c23; P{Mae-UAS.6.11}bocksbeutelDP01391
VDRC	v24189 w1118; P{GD13812}v24189 v24191 w1118; P{GD13812}v24191
Genomic Clones ( 1 )
	BACR19N07 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 66 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD45742
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH04967 GM32003 RE11717 SD02330 SD15925
Other clones	Dmel_dig_018695_0620_0562 EK101155 EK197045 EK228950 EK301050 EN14337 EP08335 RP003013296 RP003068629 RP003102238 RP003113203 RP003116198 RP003164109 RP003194952 RP003195306 RP003206258 RP003228903 RP003239992 RP003244617 RP003244625 RP003248074 RP003253454 RP003257496 RP003269635 RP003284257 RP003293923 RP003295118 RP003297710 RP003308159 RP003309617 RP003337573 RP003339481 RP003340757 RP003341403 RP003343275 RP003350071 RP003351462 RP003352658 RP003353793 RP003399975 RP003421752 RP003425363 RP003430102 RP003454530 RP003470338 RP003472044 RP003484526 RP003484764 RP003496659 RP003535108 RP003539059 RP003543134 RP003576574 RP003580335 RP003610870 RP003612807 RP003621749 RP003643650 RP003658479 RP003663010
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0037719 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 41162
Antibody Information
	polyclonal (Wagner et al., 2004)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: bocksbeutel CG9424 (FlyBase, 1996-)
Source for database merge of
Additional comments	Source for identity of bocksbeutel CG9424 was sequence comparison (date:031206). (FlyBase, 1996-)
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_141660 NM_001014611 RefSeq (Proteins) • NP_649917 NP_001014611 DDBJ / EMBL / GenBank • AAF54412 AAF54412.2 AAL39830 AAX52941 AI513462 AJ606681 AJ606682 AW943801 AY069685 CAE54810 CAE54811 Entrez Gene - A searchable database of RefSeq genes. • 41162 UniProtKB/TrEMBL • Q9VHA7 Q709R6
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Lamino-associated polypeptide 2/emerin (IPR003887) LEM-like domain (IPR011015)
Linkouts
	BioGRID - A database of protein and genetic interactions • 66321 DroID - A comprehensive database of gene and protein interactions. • FBgn0037719 DRSC - Results from RNAi screens. • FBgn0037719 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0037719 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG9424-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0037719 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 41162 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 41162 modMine - Data generated by the modENCODE project. • FBgn0037719 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • FBgn0241861 FBgn0214799 FBgn0197551 FBgn0192243 FBgn0181093 FBgn0249214 FBgn0249213 FBgn0244600 FBgn0081761 FBgn0159765 FBgn0154316 FBgn0146239 FBgn0126763 FBgn0109579 FBgn0093551 CPIJ000243 GB17890 AGAP007603 AAEL001580
Synonyms & Secondary IDs ( 5 )
Reported As
Symbol Synonym	Bocks (Pinto et al., 2008) bocksbeutel (Buszczak et al., 2007) Bocksbeutel (Pinto et al., 2007, Wilmington et al., 2008, Wagner et al., 2006) CG9424 (Wagner et al., 2004) emerin (Pinto et al., 2006)
Name Synonym	bocksbeutel (Pinto et al., 2008) Bocksbeutel (Schulze et al., 2009, Wagner et al., 2004, Wagner et al., 2006)
Secondary FlyBase IDs
References ( 20 )
Research paper	Schulze et al., 2009, PLoS ONE 4(10): e7564 A comparative study of Drosophila and human A-type lamins. [FBrf0208977] Pinto et al., 2008, Genetics 180(1): 133--145 Tissue-specific defects are caused by loss of the Drosophila MAN1 LEM domain protein. [FBrf0207348] Buszczak et al., 2007, Genetics 175(3): 1505--1531 The Carnegie protein trap library: A versatile tool for Drosophila developmental studies. [FBrf0200345] Wagner et al., 2006, Europ. J. Cell Biol. 85(2): 91--105 The Drosophila melanogaster LEM-domain protein MAN1. [FBrf0190401] Wagner et al., 2004, Europ. J. Cell Biol. 82(12): 605--616 Two novel LEM-domain proteins are splice products of the annotated Drosophila melanogaster gene CG9424 (Bocksbeutel). [FBrf0174619]
Supplementary material	The modENCODE Consortium, 2010, Science 330(6012): DataS14: Gene co-expression clusters. [FBrf0213979] Mummery-Widmer et al., 2009, Nature 458(7241): Supplementary Table 2 - Genome-wide bristle screen results. [FBrf0214518] Giot et al., 2003, Science 302(5651): Tables S1 to S7. [FBrf0166452]
Personal communication to FlyBase	Matthews, 2008.4.15, DP and HP P-element insertions submitted to the Bloomington Drosophila Stock Center. DP and HP P-element insertions submitted to the Bloomington Drosophila Stock Center. [FBrf0204789] Dickson et al., 2007.7.18, RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0200327] FlyBase Curators et al., 2004-, Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. [FBrf0174215] Ryder, 2004.4.26, Exelixis CG deletion data. Exelixis CG deletion data. [FBrf0184335]
Abstract	Wilmington et al., 2008, A. Dros. Res. Conf. 49: 540C Genetic analyses of bocksbeutel and otefin: genes encoding nuclear lamina LEM domain proteins. [FBrf0203739] Pinto et al., 2007, A. Dros. Res. Conf. 48: 136 Using Drosophila as a model to understand human laminopathies: a study of dMAN1. [FBrf0198540] Pinto et al., 2006, A. Dros. Res. Conf. 47: 833A A Study of the LEM domain proteins in Drosophila: Characterization of the putative MAN1 Homologue. [FBrf0188987]
FlyBase analysis	FlyBase, 1996-, FlyBase inference based on genome sequence analysis. FlyBase inference based on genome sequence analysis. [FBrf0104946] FlyBase, 1992-, FlyBase curation FlyBase curation. [FBrf0105495]
Computer file	BDGP Project Members, 2000-, Berkeley Drosophila Genome Project. Berkeley Drosophila Genome Project. [FBrf0125078]
Automatic genome annotation	FamiliarityBreedsContempt, 1999.11, [Annotations performed at the Celera Jamboreee.] [Annotations performed at the Celera Jamboreee.] [FBrf0126705]
DNA/RNA sequence record	Krohne, 2003.11.14, GenBank/EMBL/DDBJ: AJ606681 Drosophila melanogaster nucleomorph mRNA for bocksbeutel alpha (CG9424 gene). [FBrf0172257]