• Home
• Tools
  • Tools Overview
  • Query Tools

    
    • QuickSearch
    • QueryBuilder
    • TermLink
    • CytoSearch
    • Interactions Browser
    • ImageBrowse
    • Find A Person
    • Google™ FlyBase
  • Genomic/Map Tools

    
    • BLAST
    • GBrowse
    • CytoSearch
    • Aberrations Maps
    • Chromosome Maps
    • Coordinates Converter
  • Retrieve/Convert

    
    • Batch Download
    • Coordinates Converter
    • ID Converter
  • Data Submission

    
    • Fast-Track Your Paper
    • Submit Personal Comm
    • Add A New Person
    • Update Person Info
  • People

    
    • Find A Person
    • Add A New Person
    • Update Person Info
• Files
  • Files Overview
  • Downloads:
  • Precomputed files
  • Archived data
  • Releases (FTP)
  • Genomes (FTP)
  • AAA data (FTP)
  • Lists:
  • Transposons (Dmel)
  • Transposons (other)
  • Vectors & Constructs
  • Anatomical Terms
  • Map Conversion
• Species
  • Phylogeny
  • Sequenced Species
  • Synteny Table
  • Color Illustrations
  • Abbreviations
• Documents
  • About FlyBase
  • Reference Manual:
  • Sections
  • Contents
  • Nomenclature
  • Release Notes
• Resources
  • All Resources
  • Model Organisms
  • Stock Collections
  • Other links:
  • BDGP
  • DGRC
  • FlyExpress
  • Interactive Fly
  • modENCODE
  • Textpresso for Fly
• News
  • News
  • FlyBase Forum
  • FlyBase Positions
  • Meetings
  • Courses
  • Fly Board
  • White papers
  • Funding
  • bionet.dros
• Help
  • Google™ FlyBase
  • Site Map
  • FAQs
  • FlyBase Guides
  • Video Tutorials
  • Report help
  • New to Flies
  • Pers. comm.
  • Author guidelines
  • Contact FlyBase
• Archives
  • Prior Release
  • Other Archives
  • Coordinate Converter

Gene Dmel\Pnn

General Information
Symbol	Dmel\Pnn	Species	D. melanogaster
Name	Pinin	Annotation symbol	CG8383
Feature type	protein_coding_gene	FlyBase ID	FBgn0037737
Gene Model Status	Current	Stock availability	2 publicly available
Genomic Location
Chromosome (arm)	3R	Recombination map
Cytogenetic map	85E6-85E6	Sequence location	3R:5,566,644..5,568,167 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Pinin is referred to in FlyBase by the symbol Dmel\Pnn (CG8383, FBgn0037737). It is a protein_coding_gene from Drosophila melanogaster. Its molecular function is unknown. It is reported to be involved in the biological process: nuclear mRNA splicing, via spliceosome; RNA processing. 2 alleles are reported. No phenotypic data is available. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: Pinin/SDK/MemA protein. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 00-18 hour embryonic stages, in adult female stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult eye, larval/adult central nervous system, adult ovary. Comments on Affy2 ProbeSet: ProbeSet 1641196_at completely aligns to an exonic region common to each of the 2 FlyBase-annotated transcript isoforms of Pnn. Gene sequence location is 3R:5566644..5568167.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2011_10
FB2012_01	Sequence features BKN29449 HFA16415
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 85E6-85E6   Limits computationally determined from genome sequence between P{EP}CrcEP3006 and P{lacW}s2681
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Pnn for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Pnn-RA FBtr0082126  NM_141677   1182   303 Pnn-RB FBtr0113210  NM_001104257   1237   307
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Pnn-PA   FBpp0081604   35.9   303   10.15     NP_649934   AAF54435 Pnn-PB   FBpp0112122   36.4   307   10.18     NP_001097727   ABW08628
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Pinin/SDK/MemA protein (IPR006786)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014297 AAF54435   AE014297 ABW08628   AJ515377 CAD56383   AY071261 AAL48883   BI234175   CO178631   CO190202   CO276279   CO281225   CO288221   CO289312   CO294584   CO307264   EC060005   EC196192   EC224383   EC230245   EC233744   EC241340   EC242111   EC249436   EV596413   GH941201   GH941838   GH943273   GH943395   GH943602   GH952412   GH953677   GH955941   GH956612   GH957141   GH960052   GH960409   GH975410   GH979362   GH980192
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q8IFW3 Q9VH84 A8JQW3
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0037737    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0037737 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 00-18 hour embryonic stages, in adult female stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0037737 expression level Developmental Stage   Expression Level embryo 00-02hr    2549 embryo 02-04hr    2151 embryo 04-06hr    2373 embryo 06-08hr    2214 embryo 08-10hr    2649 embryo 10-12hr    2086 embryo 12-14hr    2038 embryo 14-16hr    767 embryo 16-18hr    881 embryo 18-20hr    447 embryo 20-22hr    910 embryo 22-24hr    1234 larva L1    309 larva L2    419 larva L3 12hr old    269 larva L3 puffstage 1-2    297 larva L3 puffstage 3-6    417 larva L3 puffstage 7-9    703 white prepupae new    743 white prepupae 12hr    797 white prepupae 24hr    978 pupae 2d postWPP    785 pupae 3d postWPP    469 pupae 4d postWPP    113 adult male 01day    270 adult male 05day    242 adult male 30day    187 adult female 01day    366 adult female 05day    1621 adult female 30day    1346 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (2549) embryo 02-04hr  (2151) embryo 04-06hr  (2373) embryo 06-08hr  (2214) embryo 08-10hr  (2649) embryo 10-12hr  (2086) embryo 12-14hr  (2038) embryo 14-16hr  (767) embryo 16-18hr  (881) embryo 18-20hr  (447) embryo 20-22hr  (910) embryo 22-24hr  (1234) larva L1  (309) larva L2  (419) larva L3 12hr old  (269) larva L3 puffstage 1-2  (297) larva L3 puffstage 3-6  (417) larva L3 puffstage 7-9  (703) white prepupae new  (743) white prepupae 12hr  (797) white prepupae 24hr  (978) pupae 2d postWPP  (785) pupae 3d postWPP  (469) pupae 4d postWPP  (113) adult male 01day  (270) adult male 05day  (242) adult male 30day  (187) adult female 01day  (366) adult female 05day  (1621) adult female 30day  (1346) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (2549) embryo 02-04hr  (2151) embryo 04-06hr  (2373) embryo 06-08hr  (2214) embryo 08-10hr  (2649) embryo 10-12hr  (2086) embryo 12-14hr  (2038) embryo 14-16hr    767 embryo 16-18hr    881 embryo 18-20hr    447 embryo 20-22hr    910 embryo 22-24hr    1234 larva L1    309 larva L2    419 larva L3 12hr old    269 larva L3 puffstage 1-2    297 larva L3 puffstage 3-6    417 larva L3 puffstage 7-9    703 white prepupae new    743 white prepupae 12hr    797 white prepupae 24hr    978 pupae 2d postWPP    785 pupae 3d postWPP    469 pupae 4d postWPP    113 adult male 01day    270 adult male 05day    242 adult male 30day    187 adult female 01day    366 adult female 05day  (1621) adult female 30day    1346 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    2549 embryo 02-04hr    2151 embryo 04-06hr    2373 embryo 06-08hr    2214 embryo 08-10hr    2649 embryo 10-12hr    2086 embryo 12-14hr    2038 embryo 14-16hr    767 embryo 16-18hr    881 embryo 18-20hr    447 embryo 20-22hr    910 embryo 22-24hr    1234 larva L1    309 larva L2    419 larva L3 12hr old    269 larva L3 puffstage 1-2    297 larva L3 puffstage 3-6    417 larva L3 puffstage 7-9    703 white prepupae new    743 white prepupae 12hr    797 white prepupae 24hr    978 pupae 2d postWPP    785 pupae 3d postWPP    469 pupae 4d postWPP    113 adult male 01day    270 adult male 05day    242 adult male 30day    187 adult female 01day    366 adult female 05day    1621 adult female 30day    1346 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    2549 embryo 02-04hr    2151 embryo 04-06hr    2373 embryo 06-08hr    2214 embryo 08-10hr    2649 embryo 10-12hr    2086 embryo 12-14hr    2038 embryo 14-16hr    767 embryo 16-18hr    881 embryo 18-20hr    447 embryo 20-22hr    910 embryo 22-24hr    1234 larva L1    309 larva L2    419 larva L3 12hr old    269 larva L3 puffstage 1-2    297 larva L3 puffstage 3-6    417 larva L3 puffstage 7-9    703 white prepupae new    743 white prepupae 12hr    797 white prepupae 24hr    978 pupae 2d postWPP    785 pupae 3d postWPP    469 pupae 4d postWPP    113 adult male 01day    270 adult male 05day    242 adult male 30day    187 adult female 01day    366 adult female 05day    1621 adult female 30day    1346 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0037737 expression level Developmental Stage   Expression Level embryo 00-02hr    2549 embryo 02-04hr    2151 embryo 04-06hr    2373 embryo 06-08hr    2214 embryo 08-10hr    2649 embryo 10-12hr    2086 embryo 12-14hr    2038 embryo 14-16hr    767 embryo 16-18hr    881 embryo 18-20hr    447 embryo 20-22hr    910 embryo 22-24hr    1234 larva L1    309 larva L2    419 larva L3 12hr old    269 larva L3 puffstage 1-2    297 larva L3 puffstage 3-6    417 larva L3 puffstage 7-9    703 white prepupae new    743 white prepupae 12hr    797 white prepupae 24hr    978 pupae 2d postWPP    785 pupae 3d postWPP    469 pupae 4d postWPP    113 adult male 01day    270 adult male 05day    242 adult male 30day    187 adult female 01day    366 adult female 05day    1621 adult female 30day    1346 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (2549) embryo 02-04hr  (2151) embryo 04-06hr  (2373) embryo 06-08hr  (2214) embryo 08-10hr  (2649) embryo 10-12hr  (2086) embryo 12-14hr  (2038) embryo 14-16hr  (767) embryo 16-18hr  (881) embryo 18-20hr  (447) embryo 20-22hr  (910) embryo 22-24hr  (1234) larva L1  (309) larva L2  (419) larva L3 12hr old  (269) larva L3 puffstage 1-2  (297) larva L3 puffstage 3-6  (417) larva L3 puffstage 7-9  (703) white prepupae new  (743) white prepupae 12hr  (797) white prepupae 24hr  (978) pupae 2d postWPP  (785) pupae 3d postWPP  (469) pupae 4d postWPP  113 adult male 01day  (270) adult male 05day  (242) adult male 30day  (187) adult female 01day  (366) adult female 05day  (1621) adult female 30day  (1346) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (2549) embryo 02-04hr  2151 embryo 04-06hr  2373 embryo 06-08hr  2214 embryo 08-10hr  (2649) embryo 10-12hr  2086 embryo 12-14hr  2038 embryo 14-16hr    767 embryo 16-18hr    881 embryo 18-20hr    447 embryo 20-22hr    910 embryo 22-24hr    1234 larva L1    309 larva L2    419 larva L3 12hr old    269 larva L3 puffstage 1-2    297 larva L3 puffstage 3-6    417 larva L3 puffstage 7-9    703 white prepupae new    743 white prepupae 12hr    797 white prepupae 24hr    978 pupae 2d postWPP    785 pupae 3d postWPP    469 pupae 4d postWPP    113 adult male 01day    270 adult male 05day    242 adult male 30day    187 adult female 01day    366 adult female 05day  1621 adult female 30day    1346 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    2549 embryo 02-04hr    2151 embryo 04-06hr    2373 embryo 06-08hr    2214 embryo 08-10hr    2649 embryo 10-12hr    2086 embryo 12-14hr    2038 embryo 14-16hr    767 embryo 16-18hr    881 embryo 18-20hr    447 embryo 20-22hr    910 embryo 22-24hr    1234 larva L1    309 larva L2    419 larva L3 12hr old    269 larva L3 puffstage 1-2    297 larva L3 puffstage 3-6    417 larva L3 puffstage 7-9    703 white prepupae new    743 white prepupae 12hr    797 white prepupae 24hr    978 pupae 2d postWPP    785 pupae 3d postWPP    469 pupae 4d postWPP    113 adult male 01day    270 adult male 05day    242 adult male 30day    187 adult female 01day    366 adult female 05day    1621 adult female 30day    1346 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    2549 embryo 02-04hr    2151 embryo 04-06hr    2373 embryo 06-08hr    2214 embryo 08-10hr    2649 embryo 10-12hr    2086 embryo 12-14hr    2038 embryo 14-16hr    767 embryo 16-18hr    881 embryo 18-20hr    447 embryo 20-22hr    910 embryo 22-24hr    1234 larva L1    309 larva L2    419 larva L3 12hr old    269 larva L3 puffstage 1-2    297 larva L3 puffstage 3-6    417 larva L3 puffstage 7-9    703 white prepupae new    743 white prepupae 12hr    797 white prepupae 24hr    978 pupae 2d postWPP    785 pupae 3d postWPP    469 pupae 4d postWPP    113 adult male 01day    270 adult male 05day    242 adult male 30day    187 adult female 01day    366 adult female 05day    1621 adult female 30day    1346 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0037737    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0037737 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult eye, larval/adult central nervous system, adult ovary. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0037737 expression level Tissue   Expression Level Larval Central Nervous System    172.125 Larval Midgut    33.1 Larval Hindgut    42.9 Larval Malpighian Tubules    49.1 Larval Fat Body    58.1 Larval Salivary Gland    49.5 Larval Trachea    47.85 Larval Carcass    42.325 Adult Head    60 Adult Eye    111.3 Adult Brain    123 Adult Thoracic-Abdominal Ganglion    73.5 Adult Crop    61.2 Adult Midgut    31.2 Adult Hindgut    32.4 Adult Malpighian Tubules    51.7 Adult Fat Body    44.6 Adult Salivary Gland    27.3 Adult Heart    36.25 Adult VirginFemale Spermatheca    74.2 Adult InseminatedFemale Spermatheca    78.4 Adult Ovary    325.3 Adult Testis    21.5 Adult Male Accessory Gland    29.4 Adult Carcass    23.2 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    172.125 Larval Midgut    33.1 Larval Hindgut    42.9 Larval Malpighian Tubules    49.1 Larval Fat Body    58.1 Larval Salivary Gland    49.5 Larval Trachea    47.85 Larval Carcass    42.325 Adult Head    60 Adult Eye    111.3 Adult Brain    123 Adult Thoracic-Abdominal Ganglion    73.5 Adult Crop    61.2 Adult Midgut    31.2 Adult Hindgut    32.4 Adult Malpighian Tubules    51.7 Adult Fat Body    44.6 Adult Salivary Gland    27.3 Adult Heart    36.25 Adult VirginFemale Spermatheca    74.2 Adult InseminatedFemale Spermatheca    78.4 Adult Ovary    325.3 Adult Testis    21.5 Adult Male Accessory Gland    29.4 Adult Carcass    23.2 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    172.125 Larval Midgut    33.1 Larval Hindgut    42.9 Larval Malpighian Tubules    49.1 Larval Fat Body    58.1 Larval Salivary Gland    49.5 Larval Trachea    47.85 Larval Carcass    42.325 Adult Head    60 Adult Eye    111.3 Adult Brain    123 Adult Thoracic-Abdominal Ganglion    73.5 Adult Crop    61.2 Adult Midgut    31.2 Adult Hindgut    32.4 Adult Malpighian Tubules    51.7 Adult Fat Body    44.6 Adult Salivary Gland    27.3 Adult Heart    36.25 Adult VirginFemale Spermatheca    74.2 Adult InseminatedFemale Spermatheca    78.4 Adult Ovary    325.3 Adult Testis    21.5 Adult Male Accessory Gland    29.4 Adult Carcass    23.2 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    172.125 Larval Midgut    33.1 Larval Hindgut    42.9 Larval Malpighian Tubules    49.1 Larval Fat Body    58.1 Larval Salivary Gland    49.5 Larval Trachea    47.85 Larval Carcass    42.325 Adult Head    60 Adult Eye    111.3 Adult Brain    123 Adult Thoracic-Abdominal Ganglion    73.5 Adult Crop    61.2 Adult Midgut    31.2 Adult Hindgut    32.4 Adult Malpighian Tubules    51.7 Adult Fat Body    44.6 Adult Salivary Gland    27.3 Adult Heart    36.25 Adult VirginFemale Spermatheca    74.2 Adult InseminatedFemale Spermatheca    78.4 Adult Ovary    325.3 Adult Testis    21.5 Adult Male Accessory Gland    29.4 Adult Carcass    23.2 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0037737 expression level Tissue   Expression Level Larval Central Nervous System    172.125 Larval Midgut    33.1 Larval Hindgut    42.9 Larval Malpighian Tubules    49.1 Larval Fat Body    58.1 Larval Salivary Gland    49.5 Larval Trachea    47.85 Larval Carcass    42.325 Adult Head    60 Adult Eye    111.3 Adult Brain    123 Adult Thoracic-Abdominal Ganglion    73.5 Adult Crop    61.2 Adult Midgut    31.2 Adult Hindgut    32.4 Adult Malpighian Tubules    51.7 Adult Fat Body    44.6 Adult Salivary Gland    27.3 Adult Heart    36.25 Adult VirginFemale Spermatheca    74.2 Adult InseminatedFemale Spermatheca    78.4 Adult Ovary    325.3 Adult Testis    21.5 Adult Male Accessory Gland    29.4 Adult Carcass    23.2 Expression Level Scale  None   Low   Moderate   High  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    172.125 Larval Midgut    33.1 Larval Hindgut    42.9 Larval Malpighian Tubules    49.1 Larval Fat Body    58.1 Larval Salivary Gland    49.5 Larval Trachea    47.85 Larval Carcass    42.325 Adult Head    60 Adult Eye    111.3 Adult Brain    123 Adult Thoracic-Abdominal Ganglion    73.5 Adult Crop    61.2 Adult Midgut    31.2 Adult Hindgut    32.4 Adult Malpighian Tubules    51.7 Adult Fat Body    44.6 Adult Salivary Gland    27.3 Adult Heart    36.25 Adult VirginFemale Spermatheca    74.2 Adult InseminatedFemale Spermatheca    78.4 Adult Ovary    325.3 Adult Testis    21.5 Adult Male Accessory Gland    29.4 Adult Carcass    23.2 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    172.125 Larval Midgut    33.1 Larval Hindgut    42.9 Larval Malpighian Tubules    49.1 Larval Fat Body    58.1 Larval Salivary Gland    49.5 Larval Trachea    47.85 Larval Carcass    42.325 Adult Head    60 Adult Eye    111.3 Adult Brain    123 Adult Thoracic-Abdominal Ganglion    73.5 Adult Crop    61.2 Adult Midgut    31.2 Adult Hindgut    32.4 Adult Malpighian Tubules    51.7 Adult Fat Body    44.6 Adult Salivary Gland    27.3 Adult Heart    36.25 Adult VirginFemale Spermatheca    74.2 Adult InseminatedFemale Spermatheca    78.4 Adult Ovary    325.3 Adult Testis    21.5 Adult Male Accessory Gland    29.4 Adult Carcass    23.2 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    172.125 Larval Midgut    33.1 Larval Hindgut    42.9 Larval Malpighian Tubules    49.1 Larval Fat Body    58.1 Larval Salivary Gland    49.5 Larval Trachea    47.85 Larval Carcass    42.325 Adult Head    60 Adult Eye    111.3 Adult Brain    123 Adult Thoracic-Abdominal Ganglion    73.5 Adult Crop    61.2 Adult Midgut    31.2 Adult Hindgut    32.4 Adult Malpighian Tubules    51.7 Adult Fat Body    44.6 Adult Salivary Gland    27.3 Adult Heart    36.25 Adult VirginFemale Spermatheca    74.2 Adult InseminatedFemale Spermatheca    78.4 Adult Ovary    325.3 Adult Testis    21.5 Adult Male Accessory Gland    29.4 Adult Carcass    23.2 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    60   NA  Eye    111.3   NA  Brain    123   172.125  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    73.5   NA  Crop    61.2   33.1  Midgut    31.2   42.9  Hindgut    32.4   49.1  Malpighian Tubules    51.7   58.1  Fat Body    44.6   49.5  Salivary Gland    27.3   NA  Heart    36.25   47.85  Trachea    NA   NA  VirginFemale Spermatheca    74.2   NA  InseminatedFemale Spermatheca    78.4   NA  Ovary    325.3   NA  Testis    21.5   NA  Male Accessory Gland    29.4   42.325  Carcass    23.2 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_17
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0037737 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG8383-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for Pnn Stages(s) 1-3 Stages(s) 4-6 Stages(s) 9-10 Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable, with Scer\GAL4pnr-MD237 PnnGD13910 Phenotype manifest in Allele
Classical Alleles ( 0 )
For All Classical Alleles Show
Allele of Pnn Class Mutagen Stocks Known lesion
Alleles Carried on Transgenic Constructs ( 2 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Pnn Class Mutagen Stocks Known lesion PnnGD13910 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes PnnKK109449 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD13910} NA P{KK109449} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions P{SUPor-P}KG01837 NA insertion of mobile activating element P{EPgy2}EY00484 NA
Gene Ontology: Function, Process & Cellular Component ( 5 unique terms )
Terms Based on Experimental Evidence ( 2 terms )
Molecular Function ( 0 terms)
Biological Process ( 0 terms)
Cellular Component
CV term Evidence References
catalytic step 2 spliceosome inferred from direct assay (Herold et al., 2009) precatalytic spliceosome inferred from direct assay (Herold et al., 2009)
Terms Based on Predictions or Assertions ( 3 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
nuclear mRNA splicing, via spliceosome inferred by curator from GO:0071011|GO:0071013 (Herold et al., 2009) RNA processing non-traceable author statement (Izaurralde, 2002.11.6)
Cellular Component
CV term Evidence References
desmosome inferred from sequence or structural similarity with NCBI:NP_032917 (FlyBase, 1992-)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Pnn allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 66344 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0037737 DroID - A comprehensive database of gene and protein interactions. • FBgn0037737 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 41185
Orthologs
Genome-wide drosophilid orthologs	Dana\GF11692 Dere\GG17059 Dgri\GH19578 Dmoj\GI23628 Dper\GL21956 Dpse\GA21034 Dsec\GM23830 Dvir\GJ11168 Dwil\GK13914 Dyak\GE25978
Curated drosophilid orthologs	Dpse\GA21034
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL013522-PA Aedes aegypti (mosquito) AGAP003316-PA Anopheles gambiae (mosquito) XP_001942626.1 Acyrthosiphon pisum (pea aphid) At1g15200.1 Arabidopsis thaliana (wall cress) 111886 Branchiostoma floridae (lancelet) XP_001902332.1 Brugia malayi (roundworm nematode) BGIBMGA000778-PA Bombyx mori (silk worm) CBP31834 Caenorhabditis briggsae (nematode) CE27772 Caenorhabditis elegans (worm) JA07085 Caenorhabditis japonica (nematode) CPIJ003278 Culex pipens (mosquito) 135392 Capitella spl (polychaete worm) 225597 Daphnia pulex (daphnia) ENSGACP00000016445 Gymnopilus aculeatus (mushroom) 174886 Hypsipyla robusta (cedar shoot borer) ISCW019483-PA Ixodes scapularis (deer tick) 232373 Nematostella vectensis (starlet anemone) XP_001600663.1 Nasonia vitripennis (wasp) PP08799 Pristionchus pacificus (nematode) 179538 Physcomitrella patens (moss) 415184 Populus trichocarpa (black cottonwood) Smp_097720 Schistosoma mansoni (trematode parasite) SPAC26F1.02 Schizosaccharomyces pombe (fission yeast) 59793 Trichoplax adhaerens (metazoa) XP_975481.1 Tribolium castaneum (red flour beetle) ENSTNIP00000019991 Tetraodon nigroviridis (green spotted pufferfish) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB17636 NV11294 LH14608 ISCW019483 FBgn0243024 FBgn0215920 FBgn0198429 FBgn0178695 JGI_V11_225597 FBgn0081022 FBgn0159549 FBgn0146354 FBgn0127042 FBgn0109287 FBgn0088732 CPIJ003278 BGIBMGA000778 ACYPI002474 GB17458 AGAP003316 AAEL013522 PHUM003190 GLEAN_08837
Stocks & Reagents
Stocks Listed in FlyBase ( 2 )
VDRC	v106336 P{KK109449}VIE-260B v35915 w1118; P{GD13910}v35915/CyO
Genomic Clones ( 2 )
	BACR23O04 BACR30F01 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 27 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	RE29832
Other clones	DPiM_RE29832
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones
Other clones	149051 Dmel_neb_015278_0951_0704 EK046961 EK057229 EK068010 EK070737 EK120244 EK156234 EK207237 EK254231 RP004064536 RP004075007 RP004089190 RP004125671 RP004145190 RP004243565 RP004248982 RP004251161 RP004251406 RP004253005 RP004261848 RP004269467 RP004343228 RP004545665 RP004549852
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0037737 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 41185
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: Pnn CG8383 (FlyBase, 1996-)
Source for database merge of
Additional comments	Source for identity of Pnn CG8383 was sequence comparison (date:021115). (FlyBase, 1996-)
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_141677 NM_001104257 RefSeq (Proteins) • NP_649934 NP_001097727 DDBJ / EMBL / GenBank • AAF54435 AAL48883 ABW08628 AJ515377 AY071261 BI234175 CAD56383 Entrez Gene - A searchable database of RefSeq genes. • 41185 UniProtKB/TrEMBL • A8JQW3 Q8IFW3 Q9VH84
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Pinin/SDK/MemA protein (IPR006786)
Linkouts
	BioGRID - A database of protein and genetic interactions • 66344 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0037737 DroID - A comprehensive database of gene and protein interactions. • FBgn0037737 DRSC - Results from RNAi screens. • FBgn0037737 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0037737 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG8383-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0037737 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 41185 InParanoid A subset of ortholog calls from InParanoid. • AAEL013522-PA Aedes aegypti (mosquito) AGAP003316-PA Anopheles gambiae (mosquito) XP_001942626.1 Acyrthosiphon pisum (pea aphid) At1g15200.1 Arabidopsis thaliana (wall cress) 111886 Branchiostoma floridae (lancelet) XP_001902332.1 Brugia malayi (roundworm nematode) BGIBMGA000778-PA Bombyx mori (silk worm) CBP31834 Caenorhabditis briggsae (nematode) CE27772 Caenorhabditis elegans (worm) JA07085 Caenorhabditis japonica (nematode) CPIJ003278 Culex pipens (mosquito) 135392 Capitella spl (polychaete worm) 225597 Daphnia pulex (daphnia) ENSGACP00000016445 Gymnopilus aculeatus (mushroom) 174886 Hypsipyla robusta (cedar shoot borer) ISCW019483-PA Ixodes scapularis (deer tick) 232373 Nematostella vectensis (starlet anemone) XP_001600663.1 Nasonia vitripennis (wasp) PP08799 Pristionchus pacificus (nematode) 179538 Physcomitrella patens (moss) 415184 Populus trichocarpa (black cottonwood) Smp_097720 Schistosoma mansoni (trematode parasite) SPAC26F1.02 Schizosaccharomyces pombe (fission yeast) 59793 Trichoplax adhaerens (metazoa) XP_975481.1 Tribolium castaneum (red flour beetle) ENSTNIP00000019991 Tetraodon nigroviridis (green spotted pufferfish) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 41185 modMine - Data generated by the modENCODE project. • FBgn0037737 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB17636 NV11294 LH14608 ISCW019483 FBgn0243024 FBgn0215920 FBgn0198429 FBgn0178695 JGI_V11_225597 FBgn0081022 FBgn0159549 FBgn0146354 FBgn0127042 FBgn0109287 FBgn0088732 CPIJ003278 BGIBMGA000778 ACYPI002474 GB17458 AGAP003316 AAEL013522 PHUM003190 GLEAN_08837
Synonyms & Secondary IDs ( 3 )
Reported As
Symbol Synonym	CG8383 (Keleman et al., 2009.8.5, Haussmann et al., 2008, Herold et al., 2009) Pnn (Herold et al., 2009)
Name Synonym	Pinin (Andersen and Tapon, 2008, Haussmann et al., 2008)
Secondary FlyBase IDs
References ( 15 )
Research paper	Herold et al., 2009, Mol. Cell. Biol. 29(1): 281--301 Conservation of the protein composition and electron microscopy structure of Drosophila melanogaster and human spliceosomal complexes. [FBrf0207172] Andersen and Tapon, 2008, J. Biol. Chem. 283(45): 31256--31267 Drosophila MFAP1 is required for pre-mRNA processing and G2/M progression. [FBrf0207382] Haussmann et al., 2008, Genome Biol. 9(4): R73 Erect wing regulates synaptic growth in Drosophila by integration of multiple signaling pathways. [FBrf0209726]
Supplementary material	The modENCODE Consortium, 2010, Science 330(6012): DataS14: Gene co-expression clusters. [FBrf0213979] Mummery-Widmer et al., 2009, Nature 458(7241): Supplementary Table 2 - Genome-wide bristle screen results. [FBrf0214518] Giot et al., 2003, Science 302(5651): Tables S1 to S7. [FBrf0166452]
Personal communication to FlyBase	Keleman et al., 2009.8.5, RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0208510] Dickson et al., 2007.7.18, RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0200327]
FlyBase analysis	FlyBase, 1996-, FlyBase inference based on genome sequence analysis. FlyBase inference based on genome sequence analysis. [FBrf0104946] FlyBase, 1992-, FlyBase curation FlyBase curation. [FBrf0105495]
DNA/RNA sequence record	Izaurralde, 2002.11.6, GenBank/EMBL/DDBJ: AJ515377 Drosophila melanogaster mRNA for Pinin (Pnn gene). [FBrf0153328]
Computer file	Gene Disruption Project members, 2001-, [title not yet available] [title not yet available] [FBrf0132177] BDGP Project Members, 2000-, Berkeley Drosophila Genome Project. Berkeley Drosophila Genome Project. [FBrf0125078]
Automatic genome annotation	FamiliarityBreedsContempt, 1999.11, [Annotations performed at the Celera Jamboreee.] [Annotations performed at the Celera Jamboreee.] [FBrf0126705]
Curated genome annotation	Yao, 1999.11, [Annotations performed at the Celera Jamboreee.] [Annotations performed at the Celera Jamboreee.] [FBrf0126699]