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Gene Dmel\CG8417

General Information
Symbol	Dmel\CG8417	Species	D. melanogaster
Name		Annotation symbol	CG8417
Feature type	protein_coding_gene	FlyBase ID	FBgn0037744
Gene Model Status	Current	Stock availability	6 publicly available
Genomic Location
Chromosome (arm)	3R	Recombination map
Cytogenetic map	85E6-85E6	Sequence location	3R:5,585,322..5,586,930 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	This gene is referred to in FlyBase by the symbol Dmel\CG8417 (FBgn0037744). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: mannose-6-phosphate isomerase activity. An electronic pipeline based on InterPro domains suggests that it is involved in the biological process: carbohydrate metabolic process. 5 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: Cupin, RmlC-type; Mannose-6-phosphate isomerase; Mannose-6-phosphate isomerase, type I; Phosphomannose isomerase, type I, conserved site; RmlC-like jelly roll fold. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of low expression. Peak expression observed at stages throughout the larval period, in adult male stages. Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, adult crop, adult midgut, adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, adult spermathecae, adult testis, larval/adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: larval/adult central nervous system, larval midgut, larval hindgut, larval trachea, adult ovary, adult male accessory gland. Comments on Affy2 ProbeSet: ProbeSet 1633934_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of CG8417. Gene sequence location is 3R:5585322..5586930.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2011_10
FB2012_01	Sequence features BKN22586 HFA16417
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 85E6-85E6   Limits computationally determined from genome sequence between P{EP}CrcEP3006 and P{lacW}s2681
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\CG8417 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.43
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) CG8417-RA FBtr0082131  NM_141683   1432   396
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein CG8417-PA   FBpp0081609   44.8   396   4.60     NP_649940   AAF54442
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Mannose-6-phosphate isomerase, type I (IPR001250) Cupin, RmlC-type (IPR011051) Phosphomannose isomerase, type I, conserved site (IPR018050) RmlC-like jelly roll fold (IPR014710) Mannose-6-phosphate isomerase (IPR016305)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014297 AAF54442   AI114069   AI294400   AI388085   AI541996   AI945859   AW940379   AY059444 AAL13350   AY075552 AAL68359   AY232213   BE977661   BF489559   BF490970   BF497709   BG631927   BI569019   BI569020   BI569752   BI570420   BI583085   BI587797   BI589232   BI590449   BI592306   BI618991   BI623428   BI631304   BP552535   CK660362   CL943675   CO303842   CO311773   CO339759   CO345096   CZ481807   EC087809   EC248258   EC248479   EC256645   EC257550   EC260741   EC260742   EL886003   GH982929
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9VH77
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0037744    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0037744 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of low expression. Peak expression observed at stages throughout the larval period, in adult male stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0037744 expression level Developmental Stage   Expression Level embryo 00-02hr    379 embryo 02-04hr    396 embryo 04-06hr    945 embryo 06-08hr    1129 embryo 08-10hr    1184 embryo 10-12hr    1608 embryo 12-14hr    1439 embryo 14-16hr    1232 embryo 16-18hr    1376 embryo 18-20hr    1689 embryo 20-22hr    2624 embryo 22-24hr    3071 larva L1    3649 larva L2    5123 larva L3 12hr old    5540 larva L3 puffstage 1-2    4366 larva L3 puffstage 3-6    2647 larva L3 puffstage 7-9    2303 white prepupae new    2318 white prepupae 12hr    1700 white prepupae 24hr    1799 pupae 2d postWPP    2228 pupae 3d postWPP    2509 pupae 4d postWPP    2400 adult male 01day    4694 adult male 05day    4269 adult male 30day    3819 adult female 01day    2592 adult female 05day    2206 adult female 30day    2105 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (379) embryo 02-04hr  (396) embryo 04-06hr  (945) embryo 06-08hr  (1129) embryo 08-10hr  (1184) embryo 10-12hr  (1608) embryo 12-14hr  (1439) embryo 14-16hr  (1232) embryo 16-18hr  (1376) embryo 18-20hr  (1689) embryo 20-22hr  (2624) embryo 22-24hr  (3071) larva L1  (3649) larva L2  (5123) larva L3 12hr old  (5540) larva L3 puffstage 1-2  (4366) larva L3 puffstage 3-6  (2647) larva L3 puffstage 7-9  (2303) white prepupae new  (2318) white prepupae 12hr  (1700) white prepupae 24hr  (1799) pupae 2d postWPP  (2228) pupae 3d postWPP  (2509) pupae 4d postWPP  (2400) adult male 01day  (4694) adult male 05day  (4269) adult male 30day  (3819) adult female 01day  (2592) adult female 05day  (2206) adult female 30day  (2105) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    379 embryo 02-04hr    396 embryo 04-06hr    945 embryo 06-08hr    1129 embryo 08-10hr    1184 embryo 10-12hr  (1608) embryo 12-14hr  1439 embryo 14-16hr    1232 embryo 16-18hr    1376 embryo 18-20hr  (1689) embryo 20-22hr  (2624) embryo 22-24hr  (3071) larva L1  (3649) larva L2  (5123) larva L3 12hr old  (5540) larva L3 puffstage 1-2  (4366) larva L3 puffstage 3-6  (2647) larva L3 puffstage 7-9  (2303) white prepupae new  (2318) white prepupae 12hr  (1700) white prepupae 24hr  (1799) pupae 2d postWPP  (2228) pupae 3d postWPP  (2509) pupae 4d postWPP  (2400) adult male 01day  (4694) adult male 05day  (4269) adult male 30day  (3819) adult female 01day  (2592) adult female 05day  (2206) adult female 30day  (2105) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    379 embryo 02-04hr    396 embryo 04-06hr    945 embryo 06-08hr    1129 embryo 08-10hr    1184 embryo 10-12hr    1608 embryo 12-14hr    1439 embryo 14-16hr    1232 embryo 16-18hr    1376 embryo 18-20hr    1689 embryo 20-22hr    2624 embryo 22-24hr    3071 larva L1    3649 larva L2    5123 larva L3 12hr old    5540 larva L3 puffstage 1-2    4366 larva L3 puffstage 3-6    2647 larva L3 puffstage 7-9    2303 white prepupae new    2318 white prepupae 12hr    1700 white prepupae 24hr    1799 pupae 2d postWPP    2228 pupae 3d postWPP    2509 pupae 4d postWPP    2400 adult male 01day    4694 adult male 05day    4269 adult male 30day    3819 adult female 01day    2592 adult female 05day    2206 adult female 30day    2105 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    379 embryo 02-04hr    396 embryo 04-06hr    945 embryo 06-08hr    1129 embryo 08-10hr    1184 embryo 10-12hr    1608 embryo 12-14hr    1439 embryo 14-16hr    1232 embryo 16-18hr    1376 embryo 18-20hr    1689 embryo 20-22hr    2624 embryo 22-24hr    3071 larva L1    3649 larva L2    5123 larva L3 12hr old    5540 larva L3 puffstage 1-2    4366 larva L3 puffstage 3-6    2647 larva L3 puffstage 7-9    2303 white prepupae new    2318 white prepupae 12hr    1700 white prepupae 24hr    1799 pupae 2d postWPP    2228 pupae 3d postWPP    2509 pupae 4d postWPP    2400 adult male 01day    4694 adult male 05day    4269 adult male 30day    3819 adult female 01day    2592 adult female 05day    2206 adult female 30day    2105 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0037744 expression level Developmental Stage   Expression Level embryo 00-02hr    379 embryo 02-04hr    396 embryo 04-06hr    945 embryo 06-08hr    1129 embryo 08-10hr    1184 embryo 10-12hr    1608 embryo 12-14hr    1439 embryo 14-16hr    1232 embryo 16-18hr    1376 embryo 18-20hr    1689 embryo 20-22hr    2624 embryo 22-24hr    3071 larva L1    3649 larva L2    5123 larva L3 12hr old    5540 larva L3 puffstage 1-2    4366 larva L3 puffstage 3-6    2647 larva L3 puffstage 7-9    2303 white prepupae new    2318 white prepupae 12hr    1700 white prepupae 24hr    1799 pupae 2d postWPP    2228 pupae 3d postWPP    2509 pupae 4d postWPP    2400 adult male 01day    4694 adult male 05day    4269 adult male 30day    3819 adult female 01day    2592 adult female 05day    2206 adult female 30day    2105 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (379) embryo 02-04hr  (396) embryo 04-06hr  (945) embryo 06-08hr  (1129) embryo 08-10hr  (1184) embryo 10-12hr  (1608) embryo 12-14hr  (1439) embryo 14-16hr  (1232) embryo 16-18hr  (1376) embryo 18-20hr  (1689) embryo 20-22hr  (2624) embryo 22-24hr  (3071) larva L1  (3649) larva L2  (5123) larva L3 12hr old  (5540) larva L3 puffstage 1-2  (4366) larva L3 puffstage 3-6  (2647) larva L3 puffstage 7-9  (2303) white prepupae new  (2318) white prepupae 12hr  (1700) white prepupae 24hr  (1799) pupae 2d postWPP  (2228) pupae 3d postWPP  (2509) pupae 4d postWPP  (2400) adult male 01day  (4694) adult male 05day  (4269) adult male 30day  (3819) adult female 01day  (2592) adult female 05day  (2206) adult female 30day  (2105) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    379 embryo 02-04hr    396 embryo 04-06hr    945 embryo 06-08hr    1129 embryo 08-10hr    1184 embryo 10-12hr  1608 embryo 12-14hr  1439 embryo 14-16hr    1232 embryo 16-18hr    1376 embryo 18-20hr  1689 embryo 20-22hr  (2624) embryo 22-24hr  (3071) larva L1  (3649) larva L2  (5123) larva L3 12hr old  (5540) larva L3 puffstage 1-2  (4366) larva L3 puffstage 3-6  (2647) larva L3 puffstage 7-9  2303 white prepupae new  2318 white prepupae 12hr  1700 white prepupae 24hr  1799 pupae 2d postWPP  2228 pupae 3d postWPP  (2509) pupae 4d postWPP  2400 adult male 01day  (4694) adult male 05day  (4269) adult male 30day  (3819) adult female 01day  (2592) adult female 05day  2206 adult female 30day  2105 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    379 embryo 02-04hr    396 embryo 04-06hr    945 embryo 06-08hr    1129 embryo 08-10hr    1184 embryo 10-12hr    1608 embryo 12-14hr    1439 embryo 14-16hr    1232 embryo 16-18hr    1376 embryo 18-20hr    1689 embryo 20-22hr    2624 embryo 22-24hr    3071 larva L1    3649 larva L2    5123 larva L3 12hr old    5540 larva L3 puffstage 1-2    4366 larva L3 puffstage 3-6    2647 larva L3 puffstage 7-9    2303 white prepupae new    2318 white prepupae 12hr    1700 white prepupae 24hr    1799 pupae 2d postWPP    2228 pupae 3d postWPP    2509 pupae 4d postWPP    2400 adult male 01day    4694 adult male 05day    4269 adult male 30day    3819 adult female 01day    2592 adult female 05day    2206 adult female 30day    2105 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    379 embryo 02-04hr    396 embryo 04-06hr    945 embryo 06-08hr    1129 embryo 08-10hr    1184 embryo 10-12hr    1608 embryo 12-14hr    1439 embryo 14-16hr    1232 embryo 16-18hr    1376 embryo 18-20hr    1689 embryo 20-22hr    2624 embryo 22-24hr    3071 larva L1    3649 larva L2    5123 larva L3 12hr old    5540 larva L3 puffstage 1-2    4366 larva L3 puffstage 3-6    2647 larva L3 puffstage 7-9    2303 white prepupae new    2318 white prepupae 12hr    1700 white prepupae 24hr    1799 pupae 2d postWPP    2228 pupae 3d postWPP    2509 pupae 4d postWPP    2400 adult male 01day    4694 adult male 05day    4269 adult male 30day    3819 adult female 01day    2592 adult female 05day    2206 adult female 30day    2105 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0037744    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0037744 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, adult crop, adult midgut, adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, adult spermathecae, adult testis, larval/adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: larval/adult central nervous system, larval midgut, larval hindgut, larval trachea, adult ovary, adult male accessory gland. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0037744 expression level Tissue   Expression Level Larval Central Nervous System    372.85 Larval Midgut    335.9 Larval Hindgut    376.4 Larval Malpighian Tubules    1199.8 Larval Fat Body    799.3 Larval Salivary Gland    680.5 Larval Trachea    354.725 Larval Carcass    1055.775 Adult Head    596.4 Adult Eye    864.075 Adult Brain    330.5 Adult Thoracic-Abdominal Ganglion    369.3 Adult Crop    1121.2 Adult Midgut    538.8 Adult Hindgut    1208 Adult Malpighian Tubules    1641.7 Adult Fat Body    1046.7 Adult Salivary Gland    1275.2 Adult Heart    838.425 Adult VirginFemale Spermatheca    875.2 Adult InseminatedFemale Spermatheca    688.8 Adult Ovary    190.2 Adult Testis    575 Adult Male Accessory Gland    465.5 Adult Carcass    856.7 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    372.85 Larval Midgut    335.9 Larval Hindgut    376.4 Larval Malpighian Tubules  (1199.8) Larval Fat Body  (799.3) Larval Salivary Gland  (680.5) Larval Trachea    354.725 Larval Carcass  (1055.775) Adult Head  (596.4) Adult Eye  (864.075) Adult Brain    330.5 Adult Thoracic-Abdominal Ganglion    369.3 Adult Crop  (1121.2) Adult Midgut  538.8 Adult Hindgut  (1208) Adult Malpighian Tubules  (1641.7) Adult Fat Body  (1046.7) Adult Salivary Gland  (1275.2) Adult Heart  (838.425) Adult VirginFemale Spermatheca  (875.2) Adult InseminatedFemale Spermatheca  (688.8) Adult Ovary    190.2 Adult Testis  (575) Adult Male Accessory Gland    465.5 Adult Carcass  (856.7) Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    372.85 Larval Midgut    335.9 Larval Hindgut    376.4 Larval Malpighian Tubules  (1199.8) Larval Fat Body    799.3 Larval Salivary Gland    680.5 Larval Trachea    354.725 Larval Carcass  1055.775 Adult Head    596.4 Adult Eye    864.075 Adult Brain    330.5 Adult Thoracic-Abdominal Ganglion    369.3 Adult Crop  (1121.2) Adult Midgut    538.8 Adult Hindgut  (1208) Adult Malpighian Tubules  (1641.7) Adult Fat Body  1046.7 Adult Salivary Gland  (1275.2) Adult Heart    838.425 Adult VirginFemale Spermatheca    875.2 Adult InseminatedFemale Spermatheca    688.8 Adult Ovary    190.2 Adult Testis    575 Adult Male Accessory Gland    465.5 Adult Carcass    856.7 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    372.85 Larval Midgut    335.9 Larval Hindgut    376.4 Larval Malpighian Tubules    1199.8 Larval Fat Body    799.3 Larval Salivary Gland    680.5 Larval Trachea    354.725 Larval Carcass    1055.775 Adult Head    596.4 Adult Eye    864.075 Adult Brain    330.5 Adult Thoracic-Abdominal Ganglion    369.3 Adult Crop    1121.2 Adult Midgut    538.8 Adult Hindgut    1208 Adult Malpighian Tubules    1641.7 Adult Fat Body    1046.7 Adult Salivary Gland    1275.2 Adult Heart    838.425 Adult VirginFemale Spermatheca    875.2 Adult InseminatedFemale Spermatheca    688.8 Adult Ovary    190.2 Adult Testis    575 Adult Male Accessory Gland    465.5 Adult Carcass    856.7 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0037744 expression level Tissue   Expression Level Larval Central Nervous System    372.85 Larval Midgut    335.9 Larval Hindgut    376.4 Larval Malpighian Tubules    1199.8 Larval Fat Body    799.3 Larval Salivary Gland    680.5 Larval Trachea    354.725 Larval Carcass    1055.775 Adult Head    596.4 Adult Eye    864.075 Adult Brain    330.5 Adult Thoracic-Abdominal Ganglion    369.3 Adult Crop    1121.2 Adult Midgut    538.8 Adult Hindgut    1208 Adult Malpighian Tubules    1641.7 Adult Fat Body    1046.7 Adult Salivary Gland    1275.2 Adult Heart    838.425 Adult VirginFemale Spermatheca    875.2 Adult InseminatedFemale Spermatheca    688.8 Adult Ovary    190.2 Adult Testis    575 Adult Male Accessory Gland    465.5 Adult Carcass    856.7 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    372.85 Larval Midgut    335.9 Larval Hindgut    376.4 Larval Malpighian Tubules  (1199.8) Larval Fat Body  799.3 Larval Salivary Gland  680.5 Larval Trachea    354.725 Larval Carcass  (1055.775) Adult Head  596.4 Adult Eye  (864.075) Adult Brain    330.5 Adult Thoracic-Abdominal Ganglion    369.3 Adult Crop  (1121.2) Adult Midgut  538.8 Adult Hindgut  (1208) Adult Malpighian Tubules  (1641.7) Adult Fat Body  (1046.7) Adult Salivary Gland  (1275.2) Adult Heart  (838.425) Adult VirginFemale Spermatheca  (875.2) Adult InseminatedFemale Spermatheca  688.8 Adult Ovary    190.2 Adult Testis  575 Adult Male Accessory Gland    465.5 Adult Carcass  (856.7) Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    372.85 Larval Midgut    335.9 Larval Hindgut    376.4 Larval Malpighian Tubules  1199.8 Larval Fat Body    799.3 Larval Salivary Gland    680.5 Larval Trachea    354.725 Larval Carcass  1055.775 Adult Head    596.4 Adult Eye    864.075 Adult Brain    330.5 Adult Thoracic-Abdominal Ganglion    369.3 Adult Crop  1121.2 Adult Midgut    538.8 Adult Hindgut  1208 Adult Malpighian Tubules  1641.7 Adult Fat Body  1046.7 Adult Salivary Gland  1275.2 Adult Heart    838.425 Adult VirginFemale Spermatheca    875.2 Adult InseminatedFemale Spermatheca    688.8 Adult Ovary    190.2 Adult Testis    575 Adult Male Accessory Gland    465.5 Adult Carcass    856.7 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    372.85 Larval Midgut    335.9 Larval Hindgut    376.4 Larval Malpighian Tubules    1199.8 Larval Fat Body    799.3 Larval Salivary Gland    680.5 Larval Trachea    354.725 Larval Carcass    1055.775 Adult Head    596.4 Adult Eye    864.075 Adult Brain    330.5 Adult Thoracic-Abdominal Ganglion    369.3 Adult Crop    1121.2 Adult Midgut    538.8 Adult Hindgut    1208 Adult Malpighian Tubules    1641.7 Adult Fat Body    1046.7 Adult Salivary Gland    1275.2 Adult Heart    838.425 Adult VirginFemale Spermatheca    875.2 Adult InseminatedFemale Spermatheca    688.8 Adult Ovary    190.2 Adult Testis    575 Adult Male Accessory Gland    465.5 Adult Carcass    856.7 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    596.4   NA  Eye    864.075   NA  Brain    330.5   372.85  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    369.3   NA  Crop    1121.2   335.9  Midgut    538.8   376.4  Hindgut    1208   1199.8  Malpighian Tubules    1641.7   799.3  Fat Body    1046.7   680.5  Salivary Gland    1275.2   NA  Heart    838.425   354.725  Trachea    NA   NA  VirginFemale Spermatheca    875.2   NA  InseminatedFemale Spermatheca    688.8   NA  Ovary    190.2   NA  Testis    575   NA  Male Accessory Gland    465.5   1055.775  Carcass    856.7 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_10
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0037744 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG8417-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for CG8417 Stages(s) 7-8 Stages(s) 9-10 Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable CG8417EY15077 viable, with Scer\GAL4pnr-MD237 CG8417GD17273 Sterility Allele fertile CG8417EY15077 Phenotype manifest in Allele
Classical Alleles ( 2 )
For All Classical Alleles Show
Allele of CG8417 Class Mutagen Stocks Known lesion CG8417e04055 piggyBac transposase 1 -- CG8417EY15077 P-element activity 1 --
Alleles Carried on Transgenic Constructs ( 3 )
For All Alleles Carried on Transgenic Constructs Show
Allele of CG8417 Class Mutagen Stocks Known lesion CG8417GD17273 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes CG8417HMS01369 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes CG8417KK102505 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD17273} NA P{KK102505} NA P{TRiP.HMS01369} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EPgy2}CG8417EY15077 NA miscellaneous insertions PBac{RB}CG8417e04055 NA
Gene Ontology: Function, Process & Cellular Component ( 3 unique terms )
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 3 terms )
Molecular Function
CV term Evidence References
mannose-6-phosphate isomerase activity inferred from sequence or structural similarity with NCBI_gi:4505235 (FlyBase, 1992-) zinc ion binding inferred from electronic annotation with InterPro:IPR001250 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
carbohydrate metabolic process inferred from electronic annotation with InterPro:IPR001250 (FlyBase Curators et al., 2004-)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions CG8417 allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 66350 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0037744 DroID - A comprehensive database of gene and protein interactions. • FBgn0037744 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 41192
Orthologs
Genome-wide drosophilid orthologs	Dana\GF23036 Dere\GG17103 Dgri\GH17406 Dmoj\GI22736 Dper\GL24302 Dpse\GA21062 Dsec\GM23834 Dsim\GD18644 Dvir\GJ22739 Dwil\GK11962 Dyak\GE25982
Curated drosophilid orthologs	Dpse\GA21062   Dyak\GE25982
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL002331-PA Aedes aegypti (mosquito) AAEL015438-PA Aedes aegypti (mosquito) AGAP000053-PA Anopheles gambiae (mosquito) XP_623842.1 Apis mellifera (honey bee) XP_001950664.1 Acyrthosiphon pisum (pea aphid) At1g67070.1 Arabidopsis thaliana (wall cress) 33280 Batrachochytrium dendrobatidis (chytrid fungus) 123669 Branchiostoma floridae (lancelet) 261743 Branchiostoma floridae (lancelet) BGIBMGA006473-PA Bombyx mori (silk worm) ENSBTAP00000007684 Bos taurus (bovine) CAL0003967 Candida albicans (a form of yeast) CN01732 Caenorhabditis brenneri (small nematode) CN02539 Caenorhabditis brenneri (small nematode) CBP32503 Caenorhabditis briggsae (nematode) CE36417 Caenorhabditis elegans (worm) ENSCAFP00000026549 Canis familiaris (dog) CAGL0J02244g Candida glabrata (haploid yeast) ENSCINP00000010975 Ciona intestinalis (sea squirt) JA18908 Caenorhabditis japonica (nematode) CMQ359C Cyanidioschyzon merolae (red alga) cn08229 Cryptococcus neoformans (yeast-like fungus) cgd8_1920 Cryptosporidium parvum (protozoan parasite) CPIJ006375 Culex pipens (mosquito) ENSCPOP00000009730 Cavia porcellus (guinea pig) 103567 Chlamidomonas reinhardtii (green alga) RP31906 Caenorhabditis remanei (nematode) ENSCSAVP00000010535 Ciona savignyi (sedentary tunicate) 229052 Capitella spl (polychaete worm) DDB0231659 Dictyostelium discoideum (amoeba) DEHA2B09350g Debaryomyces Hansenii (yeast) 128126 Daphnia pulex (daphnia) ENSDARP00000047644 Danio rerio (zebra fish) ENSECAP00000009055 Equus caballus (horse) NP_416130.3 Escherichia coli K12 (bacteria) XP_653227 Entamoeba histolytica (anaerobic protozoan) ENSGACP00000009495 Gymnopilus aculeatus (mushroom) 166495 Hypsipyla robusta (cedar shoot borer) ENSP00000318318 Homo sapiens (human) ISCW010706-PA Ixodes scapularis (deer tick) KLLA0D13728g Kluyveromyces lactis (yeast) 109203 Lottia gigantea (owl limpet) LmjF32.1580 Leishmania major (virus) 38716 Monocosta brevicollis (choanoflagellate) ENSMODP00000011544 Monodelphis domestica (gray opossum) ENSMUSP00000034856 Mus musculus (house mouse) 843 Nematostella vectensis (starlet anemone) XP_001603028.1 Nasonia vitripennis (wasp) ENSOANP00000010422 Ornithorynchus anatinus (platypus) ENSORLP00000002007 Oryzias latipes (japanese killifish) LOC_Os01g03710.1 Oryza sativa (asian rice) 15606 Ostreococcus tauri (green alga) MAL8P1.156 Plasmodium falciparum (protozoal parasite) PHUM004825-PA Pediculus humanus (human body louse) PP08127 Pristionchus pacificus (nematode) 168973 Physcomitrella patens (moss) ENSPPYP00000007544 Pongo pygmaeus (orangutan) 75143 Phytophthora ramorum (sudden oak death pathogen) 133212 Phytophthora sojae (root rot pathogen) 758948 Populus trichocarpa (black cottonwood) ENSPTRP00000012471 Pan troglodytes (chimpanzee) PVX_093650 Plasmodium vivax (protozoal parasite) ENSRNOP00000025783 Rattus norvegicus (norway rat) 4877993 Sorghum bicolor (sorghum) YER003C Saccharomyces cerevisiae (budding yeast) Smp_089590 Schistosoma mansoni (trematode parasite) SPBC2G2.16 Schizosaccharomyces pombe (fission yeast) XP_001188945.1 Strongylocentrotus purpuratus (purple sea urchin) 30639 Trichoplax adhaerens (metazoa) TA11125 Theileria annulata (apicomplexan parasite) XP_975088.1 Tribolium castaneum (red flour beetle) Tc00.1047053503677.10 Trypanosoma cruzi (parasitic trypanosome) Tc00.1047053511717.90 Trypanosoma cruzi (parasitic trypanosome) ENSTNIP00000013305 Tetraodon nigroviridis (green spotted pufferfish) TP04_0879 Theileria parva (parasitic protozoan) 9679 Thalassiosira pseudonana (marine diatom) ENSTRUP00000041150 Takifugu rubripes (pufferfish Takifugu) 3732.m00032 Tetrahymena thermophila (ciliate protozoa) 92153.m00183 Trichomonas vaginalis (parasitic flagellated protozoan) ENSXETP00000045684 Xenopus tropicalis (frog) YALI0B18348g Yarrowia lipolytica (nonconventional yeast) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV16997 LH16513 ISCW010706 FBgn0068220 FBgn0213973 FBgn0209843 FBgn0190165 FBgn0178699 JGI_V11_128126 FBgn0081050 FBgn0161892 FBgn0145463 FBgn0124876 FBgn0109331 FBgn0100030 CPIJ006375 BGIBMGA006473 ACYPI000187 GB16992 AGAP000053 AAEL015438 AAEL002331 PB22893 PHUM044270 GLEAN_07395
Stocks & Reagents
Stocks Listed in FlyBase ( 6 )
Bloomington	20968 y1 w67c23; P{EPgy2}CG8417EY15077 34379 y1 sc* v1; P{TRiP.HMS01369}attP2
Harvard	- PBac{RB}CG8417e04055
VDRC	v106461 P{KK102505}VIE-260B v49509 w1118; P{GD17273}v49509 v49508 w1118; P{GD17273}v49508/TM3
Genomic Clones ( 2 )
	BACR23O04 BACR30F01 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 37 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GH10745 RH55676
Other clones	DPiM_GH10745 yak-ad_CG8417
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT25623 AT26720 AT27612 GH18851 LP07762 LP18873 RH01893 RH02743 RH04071 RH09954 RH21531 RH28672 RH31604 RH49947 RH60856 SD07996
Other clones	103311 106376 214347.26 214537.44 214563.38 214565.31 AT11960 bs17f09 bs67d12 EK226421 EK242932 EP09348 EP21311 FGM219C10 IP17306 RH01242 RP004216146
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0037744 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 41192
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_141683 RefSeq (Proteins) • NP_649940 DDBJ / EMBL / GenBank • AAF54442 AAL13350 AAL68359 AI114069 AI388085 AI945859 AW940379 AY059444 AY075552 BI623428 CL943675 CZ481807 Entrez Gene - A searchable database of RefSeq genes. • 41192 UniProtKB/TrEMBL • Q9VH77
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Mannose-6-phosphate isomerase, type I (IPR001250) Cupin, RmlC-type (IPR011051) Phosphomannose isomerase, type I, conserved site (IPR018050) RmlC-like jelly roll fold (IPR014710) Mannose-6-phosphate isomerase (IPR016305)
Linkouts
	BioGRID - A database of protein and genetic interactions • 66350 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0037744 DroID - A comprehensive database of gene and protein interactions. • FBgn0037744 DRSC - Results from RNAi screens. • FBgn0037744 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0037744 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG8417-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0037744 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 41192 InParanoid A subset of ortholog calls from InParanoid. • AAEL002331-PA Aedes aegypti (mosquito) AAEL015438-PA Aedes aegypti (mosquito) AGAP000053-PA Anopheles gambiae (mosquito) XP_623842.1 Apis mellifera (honey bee) XP_001950664.1 Acyrthosiphon pisum (pea aphid) At1g67070.1 Arabidopsis thaliana (wall cress) 33280 Batrachochytrium dendrobatidis (chytrid fungus) 123669 Branchiostoma floridae (lancelet) 261743 Branchiostoma floridae (lancelet) BGIBMGA006473-PA Bombyx mori (silk worm) ENSBTAP00000007684 Bos taurus (bovine) CAL0003967 Candida albicans (a form of yeast) CN01732 Caenorhabditis brenneri (small nematode) CN02539 Caenorhabditis brenneri (small nematode) CBP32503 Caenorhabditis briggsae (nematode) CE36417 Caenorhabditis elegans (worm) ENSCAFP00000026549 Canis familiaris (dog) CAGL0J02244g Candida glabrata (haploid yeast) ENSCINP00000010975 Ciona intestinalis (sea squirt) JA18908 Caenorhabditis japonica (nematode) CMQ359C Cyanidioschyzon merolae (red alga) cn08229 Cryptococcus neoformans (yeast-like fungus) cgd8_1920 Cryptosporidium parvum (protozoan parasite) CPIJ006375 Culex pipens (mosquito) ENSCPOP00000009730 Cavia porcellus (guinea pig) 103567 Chlamidomonas reinhardtii (green alga) RP31906 Caenorhabditis remanei (nematode) ENSCSAVP00000010535 Ciona savignyi (sedentary tunicate) 229052 Capitella spl (polychaete worm) DDB0231659 Dictyostelium discoideum (amoeba) DEHA2B09350g Debaryomyces Hansenii (yeast) 128126 Daphnia pulex (daphnia) ENSDARP00000047644 Danio rerio (zebra fish) ENSECAP00000009055 Equus caballus (horse) NP_416130.3 Escherichia coli K12 (bacteria) XP_653227 Entamoeba histolytica (anaerobic protozoan) ENSGACP00000009495 Gymnopilus aculeatus (mushroom) 166495 Hypsipyla robusta (cedar shoot borer) ENSP00000318318 Homo sapiens (human) ISCW010706-PA Ixodes scapularis (deer tick) KLLA0D13728g Kluyveromyces lactis (yeast) 109203 Lottia gigantea (owl limpet) LmjF32.1580 Leishmania major (virus) 38716 Monocosta brevicollis (choanoflagellate) ENSMODP00000011544 Monodelphis domestica (gray opossum) ENSMUSP00000034856 Mus musculus (house mouse) 843 Nematostella vectensis (starlet anemone) XP_001603028.1 Nasonia vitripennis (wasp) ENSOANP00000010422 Ornithorynchus anatinus (platypus) ENSORLP00000002007 Oryzias latipes (japanese killifish) LOC_Os01g03710.1 Oryza sativa (asian rice) 15606 Ostreococcus tauri (green alga) MAL8P1.156 Plasmodium falciparum (protozoal parasite) PHUM004825-PA Pediculus humanus (human body louse) PP08127 Pristionchus pacificus (nematode) 168973 Physcomitrella patens (moss) ENSPPYP00000007544 Pongo pygmaeus (orangutan) 75143 Phytophthora ramorum (sudden oak death pathogen) 133212 Phytophthora sojae (root rot pathogen) 758948 Populus trichocarpa (black cottonwood) ENSPTRP00000012471 Pan troglodytes (chimpanzee) PVX_093650 Plasmodium vivax (protozoal parasite) ENSRNOP00000025783 Rattus norvegicus (norway rat) 4877993 Sorghum bicolor (sorghum) YER003C Saccharomyces cerevisiae (budding yeast) Smp_089590 Schistosoma mansoni (trematode parasite) SPBC2G2.16 Schizosaccharomyces pombe (fission yeast) XP_001188945.1 Strongylocentrotus purpuratus (purple sea urchin) 30639 Trichoplax adhaerens (metazoa) TA11125 Theileria annulata (apicomplexan parasite) XP_975088.1 Tribolium castaneum (red flour beetle) Tc00.1047053503677.10 Trypanosoma cruzi (parasitic trypanosome) Tc00.1047053511717.90 Trypanosoma cruzi (parasitic trypanosome) ENSTNIP00000013305 Tetraodon nigroviridis (green spotted pufferfish) TP04_0879 Theileria parva (parasitic protozoan) 9679 Thalassiosira pseudonana (marine diatom) ENSTRUP00000041150 Takifugu rubripes (pufferfish Takifugu) 3732.m00032 Tetrahymena thermophila (ciliate protozoa) 92153.m00183 Trichomonas vaginalis (parasitic flagellated protozoan) ENSXETP00000045684 Xenopus tropicalis (frog) YALI0B18348g Yarrowia lipolytica (nonconventional yeast) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 41192 modMine - Data generated by the modENCODE project. • FBgn0037744 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV16997 LH16513 ISCW010706 FBgn0068220 FBgn0213973 FBgn0209843 FBgn0190165 FBgn0178699 JGI_V11_128126 FBgn0081050 FBgn0161892 FBgn0145463 FBgn0124876 FBgn0109331 FBgn0100030 CPIJ006375 BGIBMGA006473 ACYPI000187 GB16992 AGAP000053 AAEL015438 AAEL002331 PB22893 PHUM044270 GLEAN_07395
Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	CG8417 (Keleman et al., 2009.8.5, Ni et al., 2010.12.1)
Name Synonym
Secondary FlyBase IDs
References ( 16 )
Research paper	Pile et al., 2003, J. Biol. Chem. 278(39): 37840--37848 The SIN3 deacetylase complex represses genes encoding mitochondrial proteins: Implications for the regulation of energy metabolism. [FBrf0162185]
Supplementary material	The modENCODE Consortium, 2010, Science 330(6012): DataS14: Gene co-expression clusters. [FBrf0213979] Mummery-Widmer et al., 2009, Nature 458(7241): Supplementary Table 2 - Genome-wide bristle screen results. [FBrf0214518] Giot et al., 2003, Science 302(5651): Tables S1 to S7. [FBrf0166452]
Personal communication to FlyBase	Ni et al., 2010.12.1, A genome-scale shRNA resource for transgenic RNAi in Drosophila. A genome-scale shRNA resource for transgenic RNAi in Drosophila. [FBrf0212437] Keleman et al., 2009.8.5, RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0208510] Dickson et al., 2007.7.18, RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0200327] FlyBase Curators et al., 2004-, Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. [FBrf0174215] Oliver, 2001.8.16, File from B. Oliver containing information on ESTs expressed in the Drosophila testis, described in Andrews et al., 2000, Genome Res. 10(12): 2030-2043 (FBrf0132348). File from B. Oliver containing information on ESTs expressed in the Drosophila testis, described in Andrews et al., 2000, Genome Res. 10(12): 2030-2043 (FBrf0132348). [FBrf0137492]
FlyBase analysis	FlyBase, 1992-, FlyBase curation FlyBase curation. [FBrf0105495]
Computer file	Gene Disruption Project members and Exelixis, 2005, Genomic mapping of Exelixis insertion collection. Genomic mapping of Exelixis insertion collection. [FBrf0184340] Gene Disruption Project members, 2001-, [title not yet available] [title not yet available] [FBrf0132177] BDGP Project Members, 2000-, Berkeley Drosophila Genome Project. Berkeley Drosophila Genome Project. [FBrf0125078]
DNA/RNA sequence record	Stapleton, 2001.10.8, GenBank/EMBL/DDBJ: AY059444 Drosophila melanogaster GH10745 full length cDNA. [FBrf0140272]
Curated genome annotation	Ketchum, 1999.11, [Annotations performed at the Celera Jamboreee.] [Annotations performed at the Celera Jamboreee.] [FBrf0126677]