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Gene Dmel\Fancl

General Information
Symbol	Dmel\Fancl	Species	D. melanogaster
Name	Fancl	Annotation symbol	CG12812
Feature type	protein_coding_gene	FlyBase ID	FBgn0037781
Gene Model Status	Current	Stock availability	3 publicly available
Genomic Location
Chromosome (arm)	3R	Recombination map
Cytogenetic map	85F8-85F8	Sequence location	3R:5,877,230..5,878,591 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Fancl is referred to in FlyBase by the symbol Dmel\Fancl (CG12812, FBgn0037781). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: ubiquitin-protein ligase activity. There is experimental evidence that it is involved in the biological process: DNA repair; protein monoubiquitination. 4 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: E3 ubiquitin-protein ligase FANCL; Fanconi anemia complex, subunit FancL, WD-repeat containing domain; Zinc finger, RING/FYVE/PHD-type. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of very low expression. Peak expression observed within 00-06 and 18-24 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval/adult midgut, adult Malpighian tubules, adult ovary. Comments on Affy2 ProbeSet: ProbeSet 1637319_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of Fancl. Gene sequence location is 3R:5877230..5878591.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 85F8-85F8   Limits computationally determined from genome sequence between P{lacW}s2681 and P{EP}Fmr1EP3517&P{PZ}tws02414
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Fancl for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.48
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Fancl-RA FBtr0082203  NM_141717   1248   381
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Fancl-PA   FBpp0081681   43.7   381   4.75     NP_649974   AAF54486
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Fanconi anemia complex, subunit FancL, WD-repeat containing domain (IPR019162) E3 ubiquitin-protein ligase FANCL (IPR026848) Zinc finger, RING/FYVE/PHD-type (IPR013083)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014297 AAF54486   AY075174 AAL68044   BF505116   BI161997   CK659179   GH946045   GH956879   GH960944   GH961763   GH967086   GH967513   GH969695   GH970251   GH972466   GH973072   GH976217   GH982332   GH983104   GH983337   GH983366
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q8T913
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 3   organism   (Fisher et al., 2012) Comment:maternally deposited
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval/adult midgut, adult Malpighian tubules, adult ovary. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    44.9 Larval Midgut    223.1 Larval Hindgut    34.5 Larval Malpighian Tubules    92.6 Larval Fat Body    13.3 Larval Salivary Gland    3.3 Larval Trachea    9.375 Larval Carcass    9.15 Adult Head    1.9 Adult Eye    3.9 Adult Brain    2.1 Adult Thoracic-Abdominal Ganglion    2.1 Adult Crop    3.8 Adult Midgut    363.2 Adult Hindgut    44.9 Adult Malpighian Tubules    128.9 Adult Fat Body    5.9 Adult Salivary Gland    10.2 Adult Heart    1.725 Adult VirginFemale Spermatheca    1.2 Adult InseminatedFemale Spermatheca    5.7 Adult Ovary    121.9 Adult Testis    59.1 Adult Male Accessory Gland    2.2 Adult Carcass    6.4 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    44.9 Larval Midgut    223.1 Larval Hindgut    34.5 Larval Malpighian Tubules    92.6 Larval Fat Body    13.3 Larval Salivary Gland    3.3 Larval Trachea    9.375 Larval Carcass    9.15 Adult Head    1.9 Adult Eye    3.9 Adult Brain    2.1 Adult Thoracic-Abdominal Ganglion    2.1 Adult Crop    3.8 Adult Midgut    363.2 Adult Hindgut    44.9 Adult Malpighian Tubules    128.9 Adult Fat Body    5.9 Adult Salivary Gland    10.2 Adult Heart    1.725 Adult VirginFemale Spermatheca    1.2 Adult InseminatedFemale Spermatheca    5.7 Adult Ovary    121.9 Adult Testis    59.1 Adult Male Accessory Gland    2.2 Adult Carcass    6.4 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    44.9 Larval Midgut    223.1 Larval Hindgut    34.5 Larval Malpighian Tubules    92.6 Larval Fat Body    13.3 Larval Salivary Gland    3.3 Larval Trachea    9.375 Larval Carcass    9.15 Adult Head    1.9 Adult Eye    3.9 Adult Brain    2.1 Adult Thoracic-Abdominal Ganglion    2.1 Adult Crop    3.8 Adult Midgut    363.2 Adult Hindgut    44.9 Adult Malpighian Tubules    128.9 Adult Fat Body    5.9 Adult Salivary Gland    10.2 Adult Heart    1.725 Adult VirginFemale Spermatheca    1.2 Adult InseminatedFemale Spermatheca    5.7 Adult Ovary    121.9 Adult Testis    59.1 Adult Male Accessory Gland    2.2 Adult Carcass    6.4 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    44.9 Larval Midgut    223.1 Larval Hindgut    34.5 Larval Malpighian Tubules    92.6 Larval Fat Body    13.3 Larval Salivary Gland    3.3 Larval Trachea    9.375 Larval Carcass    9.15 Adult Head    1.9 Adult Eye    3.9 Adult Brain    2.1 Adult Thoracic-Abdominal Ganglion    2.1 Adult Crop    3.8 Adult Midgut    363.2 Adult Hindgut    44.9 Adult Malpighian Tubules    128.9 Adult Fat Body    5.9 Adult Salivary Gland    10.2 Adult Heart    1.725 Adult VirginFemale Spermatheca    1.2 Adult InseminatedFemale Spermatheca    5.7 Adult Ovary    121.9 Adult Testis    59.1 Adult Male Accessory Gland    2.2 Adult Carcass    6.4 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    44.9 Larval Midgut    223.1 Larval Hindgut    34.5 Larval Malpighian Tubules    92.6 Larval Fat Body    13.3 Larval Salivary Gland    3.3 Larval Trachea    9.375 Larval Carcass    9.15 Adult Head    1.9 Adult Eye    3.9 Adult Brain    2.1 Adult Thoracic-Abdominal Ganglion    2.1 Adult Crop    3.8 Adult Midgut    363.2 Adult Hindgut    44.9 Adult Malpighian Tubules    128.9 Adult Fat Body    5.9 Adult Salivary Gland    10.2 Adult Heart    1.725 Adult VirginFemale Spermatheca    1.2 Adult InseminatedFemale Spermatheca    5.7 Adult Ovary    121.9 Adult Testis    59.1 Adult Male Accessory Gland    2.2 Adult Carcass    6.4 Expression Level Scale  None   Low   Moderate   High  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    44.9 Larval Midgut    223.1 Larval Hindgut    34.5 Larval Malpighian Tubules    92.6 Larval Fat Body    13.3 Larval Salivary Gland    3.3 Larval Trachea    9.375 Larval Carcass    9.15 Adult Head    1.9 Adult Eye    3.9 Adult Brain    2.1 Adult Thoracic-Abdominal Ganglion    2.1 Adult Crop    3.8 Adult Midgut    363.2 Adult Hindgut    44.9 Adult Malpighian Tubules    128.9 Adult Fat Body    5.9 Adult Salivary Gland    10.2 Adult Heart    1.725 Adult VirginFemale Spermatheca    1.2 Adult InseminatedFemale Spermatheca    5.7 Adult Ovary    121.9 Adult Testis    59.1 Adult Male Accessory Gland    2.2 Adult Carcass    6.4 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    44.9 Larval Midgut    223.1 Larval Hindgut    34.5 Larval Malpighian Tubules    92.6 Larval Fat Body    13.3 Larval Salivary Gland    3.3 Larval Trachea    9.375 Larval Carcass    9.15 Adult Head    1.9 Adult Eye    3.9 Adult Brain    2.1 Adult Thoracic-Abdominal Ganglion    2.1 Adult Crop    3.8 Adult Midgut    363.2 Adult Hindgut    44.9 Adult Malpighian Tubules    128.9 Adult Fat Body    5.9 Adult Salivary Gland    10.2 Adult Heart    1.725 Adult VirginFemale Spermatheca    1.2 Adult InseminatedFemale Spermatheca    5.7 Adult Ovary    121.9 Adult Testis    59.1 Adult Male Accessory Gland    2.2 Adult Carcass    6.4 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    44.9 Larval Midgut    223.1 Larval Hindgut    34.5 Larval Malpighian Tubules    92.6 Larval Fat Body    13.3 Larval Salivary Gland    3.3 Larval Trachea    9.375 Larval Carcass    9.15 Adult Head    1.9 Adult Eye    3.9 Adult Brain    2.1 Adult Thoracic-Abdominal Ganglion    2.1 Adult Crop    3.8 Adult Midgut    363.2 Adult Hindgut    44.9 Adult Malpighian Tubules    128.9 Adult Fat Body    5.9 Adult Salivary Gland    10.2 Adult Heart    1.725 Adult VirginFemale Spermatheca    1.2 Adult InseminatedFemale Spermatheca    5.7 Adult Ovary    121.9 Adult Testis    59.1 Adult Male Accessory Gland    2.2 Adult Carcass    6.4 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    1.9   NA  Eye    3.9   NA  Brain    2.1   44.9  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    2.1   NA  Crop    3.8   223.1  Midgut    363.2   34.5  Hindgut    44.9   92.6  Malpighian Tubules    128.9   no informative data  Fat Body    5.9   3.3  Salivary Gland    no informative data   NA  Heart    1.725   9.375  Trachea    NA   NA  VirginFemale Spermatheca    1.2   NA  InseminatedFemale Spermatheca    5.7   NA  Ovary    121.9   NA  Testis    59.1   NA  Male Accessory Gland    2.2   9.15  Carcass    6.4 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    9 central nervous system, larvae L3    2 central nervous system, pupae P8    0 head, virgin 1-day female    0 head, virgin 4-day female    0 head, virgin 20-day female    0 head, mated 1-day female    0 head, mated 4-day female    0 head, mated 20-day female    0 head, mated 1-day male    0 head, mated 4-day male    0 head, mated 20-day male    0 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    3 digestive system, larvae L3 wandering    14 digestive system, 1-day adult    20 digestive system, 4-day adult    24 digestive system, 20-day adult    24 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    2 carcass, larvae L3 wandering    1 carcass, 1-day adult    0 carcass, 4-day adult    1 carcass, 20-day adult    1 ovary, virgin 4-day female    15 ovary, mated 4-day female    9 testis, mated 4-day male    10 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    9 central nervous system, larvae L3    2 central nervous system, pupae P8    0 head, virgin 1-day female    0 head, virgin 4-day female    0 head, virgin 20-day female    0 head, mated 1-day female    0 head, mated 4-day female    0 head, mated 20-day female    0 head, mated 1-day male    0 head, mated 4-day male    0 head, mated 20-day male    0 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    3 digestive system, larvae L3 wandering    14 digestive system, 1-day adult    20 digestive system, 4-day adult    24 digestive system, 20-day adult    24 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    2 carcass, larvae L3 wandering    1 carcass, 1-day adult    0 carcass, 4-day adult    1 carcass, 20-day adult    1 ovary, virgin 4-day female    15 ovary, mated 4-day female    9 testis, mated 4-day male    10 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    9 central nervous system, larvae L3    2 central nervous system, pupae P8    0 head, virgin 1-day female    0 head, virgin 4-day female    0 head, virgin 20-day female    0 head, mated 1-day female    0 head, mated 4-day female    0 head, mated 20-day female    0 head, mated 1-day male    0 head, mated 4-day male    0 head, mated 20-day male    0 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    3 digestive system, larvae L3 wandering    14 digestive system, 1-day adult    20 digestive system, 4-day adult    24 digestive system, 20-day adult    24 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    2 carcass, larvae L3 wandering    1 carcass, 1-day adult    0 carcass, 4-day adult    1 carcass, 20-day adult    1 ovary, virgin 4-day female    15 ovary, mated 4-day female    9 testis, mated 4-day male    10 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    9 central nervous system, larvae L3    2 central nervous system, pupae P8    0 head, virgin 1-day female    0 head, virgin 4-day female    0 head, virgin 20-day female    0 head, mated 1-day female    0 head, mated 4-day female    0 head, mated 20-day female    0 head, mated 1-day male    0 head, mated 4-day male    0 head, mated 20-day male    0 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    3 digestive system, larvae L3 wandering    14 digestive system, 1-day adult    20 digestive system, 4-day adult    24 digestive system, 20-day adult    24 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    2 carcass, larvae L3 wandering    1 carcass, 1-day adult    0 carcass, 4-day adult    1 carcass, 20-day adult    1 ovary, virgin 4-day female    15 ovary, mated 4-day female    9 testis, mated 4-day male    10 accessory gland, mated 4-day male    1 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    9 central nervous system, larvae L3    2 central nervous system, pupae P8    0 head, virgin 1-day female    0 head, virgin 4-day female    0 head, virgin 20-day female    0 head, mated 1-day female    0 head, mated 4-day female    0 head, mated 20-day female    0 head, mated 1-day male    0 head, mated 4-day male    0 head, mated 20-day male    0 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    3 digestive system, larvae L3 wandering    14 digestive system, 1-day adult    20 digestive system, 4-day adult    24 digestive system, 20-day adult    24 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    2 carcass, larvae L3 wandering    1 carcass, 1-day adult    0 carcass, 4-day adult    1 carcass, 20-day adult    1 ovary, virgin 4-day female    15 ovary, mated 4-day female    9 testis, mated 4-day male    10 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    9 central nervous system, larvae L3    2 central nervous system, pupae P8    0 head, virgin 1-day female    0 head, virgin 4-day female    0 head, virgin 20-day female    0 head, mated 1-day female    0 head, mated 4-day female    0 head, mated 20-day female    0 head, mated 1-day male    0 head, mated 4-day male    0 head, mated 20-day male    0 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    3 digestive system, larvae L3 wandering    14 digestive system, 1-day adult    20 digestive system, 4-day adult    24 digestive system, 20-day adult    24 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    2 carcass, larvae L3 wandering    1 carcass, 1-day adult    0 carcass, 4-day adult    1 carcass, 20-day adult    1 ovary, virgin 4-day female    15 ovary, mated 4-day female    9 testis, mated 4-day male    10 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    9 central nervous system, larvae L3    2 central nervous system, pupae P8    0 head, virgin 1-day female    0 head, virgin 4-day female    0 head, virgin 20-day female    0 head, mated 1-day female    0 head, mated 4-day female    0 head, mated 20-day female    0 head, mated 1-day male    0 head, mated 4-day male    0 head, mated 20-day male    0 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    3 digestive system, larvae L3 wandering    14 digestive system, 1-day adult    20 digestive system, 4-day adult    24 digestive system, 20-day adult    24 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    2 carcass, larvae L3 wandering    1 carcass, 1-day adult    0 carcass, 4-day adult    1 carcass, 20-day adult    1 ovary, virgin 4-day female    15 ovary, mated 4-day female    9 testis, mated 4-day male    10 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    9 central nervous system, larvae L3    2 central nervous system, pupae P8    0 head, virgin 1-day female    0 head, virgin 4-day female    0 head, virgin 20-day female    0 head, mated 1-day female    0 head, mated 4-day female    0 head, mated 20-day female    0 head, mated 1-day male    0 head, mated 4-day male    0 head, mated 20-day male    0 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    3 digestive system, larvae L3 wandering    14 digestive system, 1-day adult    20 digestive system, 4-day adult    24 digestive system, 20-day adult    24 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    2 carcass, larvae L3 wandering    1 carcass, 1-day adult    0 carcass, 4-day adult    1 carcass, 20-day adult    1 ovary, virgin 4-day female    15 ovary, mated 4-day female    9 testis, mated 4-day male    10 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of very low expression. Peak expression observed within 00-06 and 18-24 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    20 embryo 02-04hr    7 embryo 04-06hr    7 embryo 06-08hr    5 embryo 08-10hr    5 embryo 10-12hr    2 embryo 12-14hr    1 embryo 14-16hr    2 embryo 16-18hr    6 embryo 18-20hr    14 embryo 20-22hr    11 embryo 22-24hr    22 larva L1    7 larva L2    9 larva L3 12hr old    10 larva L3 puffstage 1-2    13 larva L3 puffstage 3-6    7 larva L3 puffstage 7-9    6 white prepupae new    5 white prepupae 12hr    3 white prepupae 24hr    3 pupae 2d postWPP    2 pupae 3d postWPP    2 pupae 4d postWPP    3 adult male 01day    7 adult male 05day    9 adult male 30day    8 adult female 01day    7 adult female 05day    10 adult female 30day    12 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    20 embryo 02-04hr    7 embryo 04-06hr    7 embryo 06-08hr    5 embryo 08-10hr    5 embryo 10-12hr    2 embryo 12-14hr    1 embryo 14-16hr    2 embryo 16-18hr    6 embryo 18-20hr    14 embryo 20-22hr    11 embryo 22-24hr    22 larva L1    7 larva L2    9 larva L3 12hr old    10 larva L3 puffstage 1-2    13 larva L3 puffstage 3-6    7 larva L3 puffstage 7-9    6 white prepupae new    5 white prepupae 12hr    3 white prepupae 24hr    3 pupae 2d postWPP    2 pupae 3d postWPP    2 pupae 4d postWPP    3 adult male 01day    7 adult male 05day    9 adult male 30day    8 adult female 01day    7 adult female 05day    10 adult female 30day    12 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    20 embryo 02-04hr    7 embryo 04-06hr    7 embryo 06-08hr    5 embryo 08-10hr    5 embryo 10-12hr    2 embryo 12-14hr    1 embryo 14-16hr    2 embryo 16-18hr    6 embryo 18-20hr    14 embryo 20-22hr    11 embryo 22-24hr    22 larva L1    7 larva L2    9 larva L3 12hr old    10 larva L3 puffstage 1-2    13 larva L3 puffstage 3-6    7 larva L3 puffstage 7-9    6 white prepupae new    5 white prepupae 12hr    3 white prepupae 24hr    3 pupae 2d postWPP    2 pupae 3d postWPP    2 pupae 4d postWPP    3 adult male 01day    7 adult male 05day    9 adult male 30day    8 adult female 01day    7 adult female 05day    10 adult female 30day    12 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    20 embryo 02-04hr    7 embryo 04-06hr    7 embryo 06-08hr    5 embryo 08-10hr    5 embryo 10-12hr    2 embryo 12-14hr    1 embryo 14-16hr    2 embryo 16-18hr    6 embryo 18-20hr    14 embryo 20-22hr    11 embryo 22-24hr    22 larva L1    7 larva L2    9 larva L3 12hr old    10 larva L3 puffstage 1-2    13 larva L3 puffstage 3-6    7 larva L3 puffstage 7-9    6 white prepupae new    5 white prepupae 12hr    3 white prepupae 24hr    3 pupae 2d postWPP    2 pupae 3d postWPP    2 pupae 4d postWPP    3 adult male 01day    7 adult male 05day    9 adult male 30day    8 adult female 01day    7 adult female 05day    10 adult female 30day    12 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    20 embryo 02-04hr    7 embryo 04-06hr    7 embryo 06-08hr    5 embryo 08-10hr    5 embryo 10-12hr    2 embryo 12-14hr    1 embryo 14-16hr    2 embryo 16-18hr    6 embryo 18-20hr    14 embryo 20-22hr    11 embryo 22-24hr    22 larva L1    7 larva L2    9 larva L3 12hr old    10 larva L3 puffstage 1-2    13 larva L3 puffstage 3-6    7 larva L3 puffstage 7-9    6 white prepupae new    5 white prepupae 12hr    3 white prepupae 24hr    3 pupae 2d postWPP    2 pupae 3d postWPP    2 pupae 4d postWPP    3 adult male 01day    7 adult male 05day    9 adult male 30day    8 adult female 01day    7 adult female 05day    10 adult female 30day    12 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    20 embryo 02-04hr    7 embryo 04-06hr    7 embryo 06-08hr    5 embryo 08-10hr    5 embryo 10-12hr    2 embryo 12-14hr    1 embryo 14-16hr    2 embryo 16-18hr    6 embryo 18-20hr    14 embryo 20-22hr    11 embryo 22-24hr    22 larva L1    7 larva L2    9 larva L3 12hr old    10 larva L3 puffstage 1-2    13 larva L3 puffstage 3-6    7 larva L3 puffstage 7-9    6 white prepupae new    5 white prepupae 12hr    3 white prepupae 24hr    3 pupae 2d postWPP    2 pupae 3d postWPP    2 pupae 4d postWPP    3 adult male 01day    7 adult male 05day    9 adult male 30day    8 adult female 01day    7 adult female 05day    10 adult female 30day    12 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    20 embryo 02-04hr    7 embryo 04-06hr    7 embryo 06-08hr    5 embryo 08-10hr    5 embryo 10-12hr    2 embryo 12-14hr    1 embryo 14-16hr    2 embryo 16-18hr    6 embryo 18-20hr    14 embryo 20-22hr    11 embryo 22-24hr    22 larva L1    7 larva L2    9 larva L3 12hr old    10 larva L3 puffstage 1-2    13 larva L3 puffstage 3-6    7 larva L3 puffstage 7-9    6 white prepupae new    5 white prepupae 12hr    3 white prepupae 24hr    3 pupae 2d postWPP    2 pupae 3d postWPP    2 pupae 4d postWPP    3 adult male 01day    7 adult male 05day    9 adult male 30day    8 adult female 01day    7 adult female 05day    10 adult female 30day    12 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    20 embryo 02-04hr    7 embryo 04-06hr    7 embryo 06-08hr    5 embryo 08-10hr    5 embryo 10-12hr    2 embryo 12-14hr    1 embryo 14-16hr    2 embryo 16-18hr    6 embryo 18-20hr    14 embryo 20-22hr    11 embryo 22-24hr    22 larva L1    7 larva L2    9 larva L3 12hr old    10 larva L3 puffstage 1-2    13 larva L3 puffstage 3-6    7 larva L3 puffstage 7-9    6 white prepupae new    5 white prepupae 12hr    3 white prepupae 24hr    3 pupae 2d postWPP    2 pupae 3d postWPP    2 pupae 4d postWPP    3 adult male 01day    7 adult male 05day    9 adult male 30day    8 adult female 01day    7 adult female 05day    10 adult female 30day    12 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    5 Schneider line 2 Sg4    5 embryonic 1182-4H    5 embryonic GM2    2 embryonic Kc167    8 embryonic S1    5 embryonic S3    5 leg disc CME L1    4 wing disc CME-W2    5 wing disc ML-DmD8    3 wing disc ML-DmD9    3 wing disc ML-DmD16-c3    6 wing disc ML-DmD21    5 wing disc ML-DmD32    3 haltere disc ML-DmD17-c3    7 eye-antennal disc ML-DmD11    3 antennal disc ML-DmD20-c5    4 mixed discs ML-DmD4-c1    3 CNS ML-DmBG1-c1    10 CNS ML-DmBG2-c2    7 tumorous blood cells mbn2    4 ovary fGS/OSS    10 ovary OSC    5 ovary OSS    2 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    5 Schneider line 2 Sg4    5 embryonic 1182-4H    5 embryonic GM2    2 embryonic Kc167    8 embryonic S1    5 embryonic S3    5 leg disc CME L1    4 wing disc CME-W2    5 wing disc ML-DmD8    3 wing disc ML-DmD9    3 wing disc ML-DmD16-c3    6 wing disc ML-DmD21    5 wing disc ML-DmD32    3 haltere disc ML-DmD17-c3    7 eye-antennal disc ML-DmD11    3 antennal disc ML-DmD20-c5    4 mixed discs ML-DmD4-c1    3 CNS ML-DmBG1-c1    10 CNS ML-DmBG2-c2    7 tumorous blood cells mbn2    4 ovary fGS/OSS    10 ovary OSC    5 ovary OSS    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    5 Schneider line 2 Sg4    5 embryonic 1182-4H    5 embryonic GM2    2 embryonic Kc167    8 embryonic S1    5 embryonic S3    5 leg disc CME L1    4 wing disc CME-W2    5 wing disc ML-DmD8    3 wing disc ML-DmD9    3 wing disc ML-DmD16-c3    6 wing disc ML-DmD21    5 wing disc ML-DmD32    3 haltere disc ML-DmD17-c3    7 eye-antennal disc ML-DmD11    3 antennal disc ML-DmD20-c5    4 mixed discs ML-DmD4-c1    3 CNS ML-DmBG1-c1    10 CNS ML-DmBG2-c2    7 tumorous blood cells mbn2    4 ovary fGS/OSS    10 ovary OSC    5 ovary OSS    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    5 Schneider line 2 Sg4    5 embryonic 1182-4H    5 embryonic GM2    2 embryonic Kc167    8 embryonic S1    5 embryonic S3    5 leg disc CME L1    4 wing disc CME-W2    5 wing disc ML-DmD8    3 wing disc ML-DmD9    3 wing disc ML-DmD16-c3    6 wing disc ML-DmD21    5 wing disc ML-DmD32    3 haltere disc ML-DmD17-c3    7 eye-antennal disc ML-DmD11    3 antennal disc ML-DmD20-c5    4 mixed discs ML-DmD4-c1    3 CNS ML-DmBG1-c1    10 CNS ML-DmBG2-c2    7 tumorous blood cells mbn2    4 ovary fGS/OSS    10 ovary OSC    5 ovary OSS    2 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    5 Schneider line 2 Sg4    5 embryonic 1182-4H    5 embryonic GM2    2 embryonic Kc167    8 embryonic S1    5 embryonic S3    5 leg disc CME L1    4 wing disc CME-W2    5 wing disc ML-DmD8    3 wing disc ML-DmD9    3 wing disc ML-DmD16-c3    6 wing disc ML-DmD21    5 wing disc ML-DmD32    3 haltere disc ML-DmD17-c3    7 eye-antennal disc ML-DmD11    3 antennal disc ML-DmD20-c5    4 mixed discs ML-DmD4-c1    3 CNS ML-DmBG1-c1    10 CNS ML-DmBG2-c2    7 tumorous blood cells mbn2    4 ovary fGS/OSS    10 ovary OSC    5 ovary OSS    2 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    5 Schneider line 2 Sg4    5 embryonic 1182-4H    5 embryonic GM2    2 embryonic Kc167    8 embryonic S1    5 embryonic S3    5 leg disc CME L1    4 wing disc CME-W2    5 wing disc ML-DmD8    3 wing disc ML-DmD9    3 wing disc ML-DmD16-c3    6 wing disc ML-DmD21    5 wing disc ML-DmD32    3 haltere disc ML-DmD17-c3    7 eye-antennal disc ML-DmD11    3 antennal disc ML-DmD20-c5    4 mixed discs ML-DmD4-c1    3 CNS ML-DmBG1-c1    10 CNS ML-DmBG2-c2    7 tumorous blood cells mbn2    4 ovary fGS/OSS    10 ovary OSC    5 ovary OSS    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    5 Schneider line 2 Sg4    5 embryonic 1182-4H    5 embryonic GM2    2 embryonic Kc167    8 embryonic S1    5 embryonic S3    5 leg disc CME L1    4 wing disc CME-W2    5 wing disc ML-DmD8    3 wing disc ML-DmD9    3 wing disc ML-DmD16-c3    6 wing disc ML-DmD21    5 wing disc ML-DmD32    3 haltere disc ML-DmD17-c3    7 eye-antennal disc ML-DmD11    3 antennal disc ML-DmD20-c5    4 mixed discs ML-DmD4-c1    3 CNS ML-DmBG1-c1    10 CNS ML-DmBG2-c2    7 tumorous blood cells mbn2    4 ovary fGS/OSS    10 ovary OSC    5 ovary OSS    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    5 Schneider line 2 Sg4    5 embryonic 1182-4H    5 embryonic GM2    2 embryonic Kc167    8 embryonic S1    5 embryonic S3    5 leg disc CME L1    4 wing disc CME-W2    5 wing disc ML-DmD8    3 wing disc ML-DmD9    3 wing disc ML-DmD16-c3    6 wing disc ML-DmD21    5 wing disc ML-DmD32    3 haltere disc ML-DmD17-c3    7 eye-antennal disc ML-DmD11    3 antennal disc ML-DmD20-c5    4 mixed discs ML-DmD4-c1    3 CNS ML-DmBG1-c1    10 CNS ML-DmBG2-c2    7 tumorous blood cells mbn2    4 ovary fGS/OSS    10 ovary OSC    5 ovary OSS    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    3 cold shock, 4-day adult    3 heat shock, 4-day adult    13 Cadmium 50 mM 6 hrs, larvae L3    11 Cadmium 50 mM 12 hrs, larvae L3    10 Cadmium 50 mM 48 hrs, 4-day adult    12 Cadmium 100 mM 48 hrs, 4-day adult    11 Copper 0.5 mM 12 hrs, larvae L3    7 Copper 15 mM 48 hrs, 4-day adult    7 Zinc 5 mM 12 hrs, larvae L3    4 Zinc 4.5 mM 48 hrs, 4-day adult    6 Ethanol 2.5% 3 hrs, larvae L3    13 Ethanol 5% 3 hrs, larvae L3    24 Ethanol 10% 3 hrs, larvae L3    13 Caffeine 1.5 mg/ml 4 hrs, larvae L3    14 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    9 Caffeine 25 mg/ml 48 hrs, 4-day adult    5 Paraquat 5 mM 48 hrs, 4-day adult    13 Paraquat 10 mM 48 hrs, 4-day adult    8 Rotenone 2 μg 12 hrs, larvae L3    15 Rotenone 8 μg 12 hrs, larvae L3    12 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    3 cold shock, 4-day adult    3 heat shock, 4-day adult    13 Cadmium 50 mM 6 hrs, larvae L3    11 Cadmium 50 mM 12 hrs, larvae L3    10 Cadmium 50 mM 48 hrs, 4-day adult    12 Cadmium 100 mM 48 hrs, 4-day adult    11 Copper 0.5 mM 12 hrs, larvae L3    7 Copper 15 mM 48 hrs, 4-day adult    7 Zinc 5 mM 12 hrs, larvae L3    4 Zinc 4.5 mM 48 hrs, 4-day adult    6 Ethanol 2.5% 3 hrs, larvae L3    13 Ethanol 5% 3 hrs, larvae L3    24 Ethanol 10% 3 hrs, larvae L3    13 Caffeine 1.5 mg/ml 4 hrs, larvae L3    14 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    9 Caffeine 25 mg/ml 48 hrs, 4-day adult    5 Paraquat 5 mM 48 hrs, 4-day adult    13 Paraquat 10 mM 48 hrs, 4-day adult    8 Rotenone 2 μg 12 hrs, larvae L3    15 Rotenone 8 μg 12 hrs, larvae L3    12 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    3 cold shock, 4-day adult    3 heat shock, 4-day adult    13 Cadmium 50 mM 6 hrs, larvae L3    11 Cadmium 50 mM 12 hrs, larvae L3    10 Cadmium 50 mM 48 hrs, 4-day adult    12 Cadmium 100 mM 48 hrs, 4-day adult    11 Copper 0.5 mM 12 hrs, larvae L3    7 Copper 15 mM 48 hrs, 4-day adult    7 Zinc 5 mM 12 hrs, larvae L3    4 Zinc 4.5 mM 48 hrs, 4-day adult    6 Ethanol 2.5% 3 hrs, larvae L3    13 Ethanol 5% 3 hrs, larvae L3    24 Ethanol 10% 3 hrs, larvae L3    13 Caffeine 1.5 mg/ml 4 hrs, larvae L3    14 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    9 Caffeine 25 mg/ml 48 hrs, 4-day adult    5 Paraquat 5 mM 48 hrs, 4-day adult    13 Paraquat 10 mM 48 hrs, 4-day adult    8 Rotenone 2 μg 12 hrs, larvae L3    15 Rotenone 8 μg 12 hrs, larvae L3    12 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    3 cold shock, 4-day adult    3 heat shock, 4-day adult    13 Cadmium 50 mM 6 hrs, larvae L3    11 Cadmium 50 mM 12 hrs, larvae L3    10 Cadmium 50 mM 48 hrs, 4-day adult    12 Cadmium 100 mM 48 hrs, 4-day adult    11 Copper 0.5 mM 12 hrs, larvae L3    7 Copper 15 mM 48 hrs, 4-day adult    7 Zinc 5 mM 12 hrs, larvae L3    4 Zinc 4.5 mM 48 hrs, 4-day adult    6 Ethanol 2.5% 3 hrs, larvae L3    13 Ethanol 5% 3 hrs, larvae L3    24 Ethanol 10% 3 hrs, larvae L3    13 Caffeine 1.5 mg/ml 4 hrs, larvae L3    14 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    9 Caffeine 25 mg/ml 48 hrs, 4-day adult    5 Paraquat 5 mM 48 hrs, 4-day adult    13 Paraquat 10 mM 48 hrs, 4-day adult    8 Rotenone 2 μg 12 hrs, larvae L3    15 Rotenone 8 μg 12 hrs, larvae L3    12 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    3 cold shock, 4-day adult    3 heat shock, 4-day adult    13 Cadmium 50 mM 6 hrs, larvae L3    11 Cadmium 50 mM 12 hrs, larvae L3    10 Cadmium 50 mM 48 hrs, 4-day adult    12 Cadmium 100 mM 48 hrs, 4-day adult    11 Copper 0.5 mM 12 hrs, larvae L3    7 Copper 15 mM 48 hrs, 4-day adult    7 Zinc 5 mM 12 hrs, larvae L3    4 Zinc 4.5 mM 48 hrs, 4-day adult    6 Ethanol 2.5% 3 hrs, larvae L3    13 Ethanol 5% 3 hrs, larvae L3    24 Ethanol 10% 3 hrs, larvae L3    13 Caffeine 1.5 mg/ml 4 hrs, larvae L3    14 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    9 Caffeine 25 mg/ml 48 hrs, 4-day adult    5 Paraquat 5 mM 48 hrs, 4-day adult    13 Paraquat 10 mM 48 hrs, 4-day adult    8 Rotenone 2 μg 12 hrs, larvae L3    15 Rotenone 8 μg 12 hrs, larvae L3    12 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    3 cold shock, 4-day adult    3 heat shock, 4-day adult    13 Cadmium 50 mM 6 hrs, larvae L3    11 Cadmium 50 mM 12 hrs, larvae L3    10 Cadmium 50 mM 48 hrs, 4-day adult    12 Cadmium 100 mM 48 hrs, 4-day adult    11 Copper 0.5 mM 12 hrs, larvae L3    7 Copper 15 mM 48 hrs, 4-day adult    7 Zinc 5 mM 12 hrs, larvae L3    4 Zinc 4.5 mM 48 hrs, 4-day adult    6 Ethanol 2.5% 3 hrs, larvae L3    13 Ethanol 5% 3 hrs, larvae L3    24 Ethanol 10% 3 hrs, larvae L3    13 Caffeine 1.5 mg/ml 4 hrs, larvae L3    14 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    9 Caffeine 25 mg/ml 48 hrs, 4-day adult    5 Paraquat 5 mM 48 hrs, 4-day adult    13 Paraquat 10 mM 48 hrs, 4-day adult    8 Rotenone 2 μg 12 hrs, larvae L3    15 Rotenone 8 μg 12 hrs, larvae L3    12 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    3 cold shock, 4-day adult    3 heat shock, 4-day adult    13 Cadmium 50 mM 6 hrs, larvae L3    11 Cadmium 50 mM 12 hrs, larvae L3    10 Cadmium 50 mM 48 hrs, 4-day adult    12 Cadmium 100 mM 48 hrs, 4-day adult    11 Copper 0.5 mM 12 hrs, larvae L3    7 Copper 15 mM 48 hrs, 4-day adult    7 Zinc 5 mM 12 hrs, larvae L3    4 Zinc 4.5 mM 48 hrs, 4-day adult    6 Ethanol 2.5% 3 hrs, larvae L3    13 Ethanol 5% 3 hrs, larvae L3    24 Ethanol 10% 3 hrs, larvae L3    13 Caffeine 1.5 mg/ml 4 hrs, larvae L3    14 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    9 Caffeine 25 mg/ml 48 hrs, 4-day adult    5 Paraquat 5 mM 48 hrs, 4-day adult    13 Paraquat 10 mM 48 hrs, 4-day adult    8 Rotenone 2 μg 12 hrs, larvae L3    15 Rotenone 8 μg 12 hrs, larvae L3    12 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    3 cold shock, 4-day adult    3 heat shock, 4-day adult    13 Cadmium 50 mM 6 hrs, larvae L3    11 Cadmium 50 mM 12 hrs, larvae L3    10 Cadmium 50 mM 48 hrs, 4-day adult    12 Cadmium 100 mM 48 hrs, 4-day adult    11 Copper 0.5 mM 12 hrs, larvae L3    7 Copper 15 mM 48 hrs, 4-day adult    7 Zinc 5 mM 12 hrs, larvae L3    4 Zinc 4.5 mM 48 hrs, 4-day adult    6 Ethanol 2.5% 3 hrs, larvae L3    13 Ethanol 5% 3 hrs, larvae L3    24 Ethanol 10% 3 hrs, larvae L3    13 Caffeine 1.5 mg/ml 4 hrs, larvae L3    14 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    9 Caffeine 25 mg/ml 48 hrs, 4-day adult    5 Paraquat 5 mM 48 hrs, 4-day adult    13 Paraquat 10 mM 48 hrs, 4-day adult    8 Rotenone 2 μg 12 hrs, larvae L3    15 Rotenone 8 μg 12 hrs, larvae L3    12 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_20 mE1_20_mRNA_expression_cluster_05
External Data & Images
Linkouts	BDGP expression data • AT07283 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0037781 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG12812-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable, with Scer\GAL4pnr-MD237 FanclGD7835 Other Phenotypes Allele chemical sensitive, with Scer\GAL4ey.PU FancldsRNA.Scer\UAS visible | chemical conditional, with Scer\GAL4ey.PU FancldsRNA.Scer\UAS Phenotype manifest in Allele eye | chemical conditional, with Scer\GAL4ey.PU FancldsRNA.Scer\UAS
Classical Alleles ( 0 )
For All Classical Alleles Show
Allele of Fancl Class Mutagen Stocks Known lesion
Alleles Carried on Transgenic Constructs ( 4 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Fancl Class Mutagen Stocks Known lesion FanclGD7835 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes FanclHMS00771 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes FancldsRNA.Scer\UAS in vitro construct - RNAi 0 Yes FanclNIG.12812R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3R)Exel6155 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD7835} NA P{NIG.12812R} NA P{TRiP.HMS00771} NA P{UASFancl.RNAi} NA
Insertions
	Type of insertions Name Expression data
Gene Ontology: Function, Process & Cellular Component ( 4 unique terms )
Terms Based on Experimental Evidence ( 2 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
DNA repair inferred from mutant phenotype (Marek and Bale, 2006) protein monoubiquitination inferred from mutant phenotype (Marek and Bale, 2006)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 2 terms )
Molecular Function
CV term Evidence References
ubiquitin-protein ligase activity inferred from sequence or structural similarity with HGNC_gene:FANCL, HGNC:20748 (Curators, 2008--)
Biological Process ( 0 terms)
Cellular Component
CV term Evidence References
Fanconi anaemia nuclear complex inferred from electronic annotation with InterPro:IPR026848 (FlyBase Curators et al., 2004-)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
Fancl - CG9114 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Fancl allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 66386 DroID - A comprehensive database of gene and protein interactions. • FBgn0037781 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 41231
Orthologs
OrthoDB Orthologs (37) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6TB4XG Dipteran inclusive ortholog search EOG6ZPF43 Insect inclusive ortholog search EOG6SF82P Arthropod inclusive ortholog search EOG6T1G37 Metazoa inclusive ortholog search EOG6J74JS
Orthologs in Drosophila Species (EOG6TB4XG)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\Fancl     Drosophila simulans   Dsim\GD20739 Y   Drosophila sechellia   Dsec\GM26190 Y   Drosophila erecta   Dere\GG17306 Y   Drosophila yakuba   Dyak\GE24708 Y   Drosophila ananassae   Dana\GF17137 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA11825 Y   Drosophila persimilis   Dper\GL27281 Y   Drosophila willistoni   Dwil\GK11033 Y   Drosophila virilis   Dvir\GJ10724 Y   Drosophila mojavensis   Dmoj\GI24447 Y   Drosophila grimshawi   Dgri\GH17888 Y
Orthologs in non-Drosophila Dipterans (EOG6ZPF43)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL003271   Anopheles gambiae Malaria mosquito  Agam\AGAP005271   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ801483
Orthologs in non-Dipteran Insects (EOG6SF82P)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB49338   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG000130   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH17778   Atta cephalotes Leafcutter ant  Acep\ACEP15664   Camponotus floridanus Florida carpenter ant  Cflo\CFLO14210   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL12690   Linepithema humile Argentine ant  Lhum\LH13337   Pogonomyrmex barbatus Red harvester ant  Pbar\PB14535   Solenopsis invicta Red fire ant  Sinv\SINV14752   Acyrthosiphon pisum Pea aphid  Apim\ACYPI002696   Pediculus humanus Human body louse  Phum\PHUM117540   Tribolium castaneum Red flour beetle  Tcas\GLEAN_15661
Orthologs in non-Insect Arthropods (EOG6T1G37)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\Camk1g   Ixodes scapularis Deer tick  Isca\ISCW013679
Orthologs in non-Arthropod Metazoa (EOG6J74JS)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_004252gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_005276gn   Danio rerio Zebrafish  Drer\fancl   Xenopus tropicalis Western clawed frog  Xtro\fancl   Gallus gallus Domestic chicken  Ggal\FANCL   Mus musculus House mouse  Mmus\Fancl   Rattus norvegicus Norway rat  Rnor\Fancl   Homo sapiens Human  Hsap\FANCL
Human Orthologs (1)
Gene OMIM HGNC Hsap\FANCL
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD20739 Drosophila sechellia Dsec\GM26190 Drosophila erecta Dere\GG17306 Drosophila yakuba Dyak\GE24708 Drosophila ananassae Dana\GF17137 Drosophila pseudoobscura pseudoobscura Dpse\GA11825 Drosophila persimilis Dper\GL27281 Drosophila willistoni Dwil\GK11033 Drosophila virilis Dvir\GJ10724 Drosophila mojavensis Dmoj\GI24447 Drosophila grimshawi Dgri\GH17888
Stocks & Reagents
Stocks Listed in FlyBase ( 3 )
Bloomington	33050 y1 sc* v1; P{TRiP.HMS00771}attP2
VDRC	v32025 w1118; P{GD7835}v32025 v32027 w1118; P{GD7835}v32027
Genomic Clones ( 1 )
	BACR39F04 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 18 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	AT07283
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	LP16755
Other clones	RE01434 RP004070374 RP004210934 RP004211403 RP004214115 RP004221957 RP004223313 RP004324364 RP004387841 RP004396818 RP004430081 RP004437865 RP004466758 RP004472023 RP004533481 RP004539190
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0037781 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 41231
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: Fancl CG12812 (Marek, 2006.2.28)
Source for database merge of
Additional comments
Other Comments
	Knockdown of Fancl function results in specific hypersensitivity to cross-linking agents, which is observed as a higher frequency of chromosome fusions. (Marek and Bale, 2006)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_141717 RefSeq (Proteins) • NP_649974 DDBJ / EMBL / GenBank • AAF54486 AAL68044 AY075174 BF505116 Entrez Gene - A searchable database of RefSeq genes. • 41231 UniProtKB/TrEMBL • Q8T913
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Fanconi anemia complex, subunit FancL, WD-repeat containing domain (IPR019162) E3 ubiquitin-protein ligase FANCL (IPR026848) Zinc finger, RING/FYVE/PHD-type (IPR013083) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • AT07283
Linkouts
	BioGRID - A database of protein and genetic interactions • 66386 DroID - A comprehensive database of gene and protein interactions. • FBgn0037781 DRSC - Results from RNAi screens. • FBgn0037781 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0037781 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG12812-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0037781 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 41231 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 41231 modMine - Data generated by the modENCODE project. • FBgn0037781
Synonyms & Secondary IDs ( 4 )
Reported As
Symbol Synonym	CG12812 (Giot et al., 2003, Beuchle et al., 2007, Ni et al., 2010.12.1) FAL (Marek and Bale, 2006) FANCL (Marek and Bale, 2006, Marek and Bale, 2006) Fancl (Japanese National Institute of Genetics, 2012.5.21)
Name Synonym	Fancl (Marek, 2006.2.28)
Secondary FlyBase IDs
References ( 20 )
Research paper	Beuchle et al., 2007, Mech. Dev. 124(5): 390--406 Drosophila MICAL regulates myofilament organization and synaptic structure. [FBrf0200539] Marek and Bale, 2006, DNA Repair 5(11): 1317--1326 Drosophila homologs of FANCD2 and FANCL function in DNA repair. [FBrf0192069] Meetei et al., 2004, Cell Cycle 3(2): 179--181 FANCL replaces BRCA1 as the likely ubiquitin ligase responsible for FANCD2 monoubiquitination. [FBrf0191641]
Supplementary material	Graveley et al., 2011, Nature 471(7339): Supplementary Table 33. Fuzzy Cluster Members. [FBrf0213980] The modENCODE Consortium, 2010, Science 330(6012): DataS14: Gene co-expression clusters. [FBrf0213979] Mummery-Widmer et al., 2009, Nature 458(7241): Supplementary Table 2 - Genome-wide bristle screen results. [FBrf0214518] Giot et al., 2003, Science 302(5651): Tables S1 to S7. [FBrf0166452]
Personal communication to FlyBase	Ni et al., 2010.12.1, A genome-scale shRNA resource for transgenic RNAi in Drosophila. A genome-scale shRNA resource for transgenic RNAi in Drosophila. [FBrf0212437] Mintseris et al., 2009.11.23, DPiM: the Drosophila Protein Interaction Mapping project DPiM: the Drosophila Protein Interaction Mapping project [FBrf0209452] Dickson et al., 2007.7.18, RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0200327] Marek, 2006.2.28, Helping FlyBase: ADRC.06-60320. Helping FlyBase: ADRC.06-60320. [FBrf0191640] FlyBase Curators et al., 2004-, Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. [FBrf0174215] Ryder, 2004.4.26, Exelixis CG deletion data. Exelixis CG deletion data. [FBrf0184335] BDGP Project Members, 2000-, Berkeley Drosophila Genome Project. (Computer file) Berkeley Drosophila Genome Project. (Computer file) [FBrf0125078]
Abstract	Marek and Bale, 2006, A. Dros. Res. Conf. 47: 67 Drosophila homologs of FANCD2 and FANCL function in DNA repair. [FBrf0189123]
FlyBase analysis	FlyBase Curators, 2010-, Gene Ontology (GO) annotation review. Gene Ontology (GO) annotation review. [FBrf0216433] Curators, 2008--, Assigning Gene Ontology (GO) terms by sequence similarity in FlyBase. Assigning Gene Ontology (GO) terms by sequence similarity in FlyBase. [FBrf0202953] FlyBase Curators, 2002-, Use of the ND evidence code for Gene Ontology (GO) terms in FlyBase. Use of the ND evidence code for Gene Ontology (GO) terms in FlyBase. [FBrf0159398]
Stock list	Japanese National Institute of Genetics, 2012.5.21, RNAi stocks available from NIG-FLY. RNAi stocks available from NIG-FLY. [FBrf0218457]
Website	Fisher et al., 2012, BDGP insitu homepage BDGP insitu homepage [FBrf0219073]