Gene Dmel\CG4706

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General Information

Symbol

Dmel\CG4706

Species

D. melanogaster

Name

Annotation symbol

CG4706

Feature type

protein_coding_gene

FlyBase ID

FBgn0037862

Gene Model Status

Current

Stock availability

4 publicly available

Genomic Location

Chromosome (arm)

Recombination map

Cytogenetic map

86D4-86D4

Sequence location

3R:6,962,899..6,965,467 [+]

Genomic Maps

Select View:

Summary Information

Automatically generated summary

See sections below for more information

This gene is referred to in FlyBase by the symbol Dmel\CG4706 (FBgn0037862). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: aconitate hydratase activity. There is experimental evidence that it is involved in the biological process: multicellular organism reproduction. 4 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: Aconitase A/isopropylmalate dehydratase small subunit, swivel; Aconitase family, 4Fe-4S cluster binding site; Aconitase, mitochondrial-like; Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha; Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha, subdomain 1/3; Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha, subdomain 2; Aconitase/3-isopropylmalate dehydratase, swivel; Aconitase/isopropylmalate dehydratase. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of no expression detected. Peak expression observed in adult male stages. Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult testis. Comments on Affy2 ProbeSet: ProbeSet 1630300_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of CG4706. Gene sequence location is 3R:6962899..6965467.

User Contributed Data

Beta version, feedback welcome

Recent Updates

Description

What does this section display?

This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms).

What does this section not display?

This section does not currently display links that were removed or gene model changes.

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FB2013_03

FB2013_02

All updates

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Detailed Mapping Data

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

86D4-86D4

Limits computationally determined from genome sequence between P{EP}EP3340^EP3340 and P{PZ}tho¹&P{PZ}l(3)04629⁰⁵²⁷⁵

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

Left of (cM)

Right of (cM)

Notes

Gene Model & Products

Please see the GBrowse view of Dmel\CG4706 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Comments on Gene Model

Gene model reviewed during 5.47

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Associated CDS (aa)

CG4706-RA

FBtr0082336

NM_141785

2569

783

Additional Transcript Data & Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank protein

CG4706-PA

FBpp0081812

85.1

783

7.11

NP_650042

AAF54588

Additional Polypeptide Data & Comments

Reported size (kDa)

Comments

External Data

Linkouts

Crossreferences

InterPro domains - A database of protein families, domains, and functional sites

•

Aconitase A/isopropylmalate dehydratase small subunit, swivel (IPR000573)

Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha (IPR001030)

Aconitase, mitochondrial-like (IPR006248)

Aconitase family, 4Fe-4S cluster binding site (IPR018136)

Aconitase/3-isopropylmalate dehydratase, swivel (IPR015928)

Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha, subdomain 1/3 (IPR015931)

Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha, subdomain 2 (IPR015932)

Aconitase/isopropylmalate dehydratase (IPR015937)

MitoDrome - A database of annotated Dmel nuclear genes encoding mitochondrial proteins

•

MTDROME04706

Sequences Consistent with the Gene Model

DDBJ /
EMBL /
GenBank

DNA sequence

Protein sequence

Name

Q8T4D6

Mapped Features

Mapped Features have been reorganized, please see this article for details.

Additional mapped features and mutations can be found on GBrowse or related reports.

Type

Symbol & Location

Additional Notes

References

External Data

Linkouts

Crossreferences

Expression Data

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 3

organism

(Fisher et al., 2012)

Comment:maternally deposited

embryonic stage 4 -- 6

organism

(Fisher et al., 2012)

embryonic stage 13 -- 16

embryonic/larval midgut

(Fisher et al., 2012)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

day 5 of adulthood & male -- day 7 of adulthood & male

spermatozoon

(Dorus et al., 2006, Wasbrough et al., 2010)

Additional Descriptive Data

Marker for

Subcellular Localization (GO Cellular Component)

CV term

Evidence

References

extracellular space

inferred from direct assay

(Findlay et al., 2009)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

Reference

See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.

FlyAtlas Anatomy Microarray

FlyAtlas Anatomical Expression Data

(FlyAtlas-RNA.adult)

(FlyAtlas-RNA.larva)

	Styles
	Linear
	Logarithmic
	Heatmap
	Back-to-back
	Scales
	gene max expression
	Moderate expression bin max
	High level expression bin max
	Very high expression bin max

Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult testis.
[download data (TSV)]

Guide to FlyAtlas expression level colors
	No expression (0 - 9.999)
	Low expression (10 - 99.999)
	Moderate expression (100 - 499.999)
	High level expression (500 - 999.999)
	Very high expression (>999.999)

Linear, scaled to maximum expression level
Tissue		Expression Level
Larval Central Nervous System		1.65
Larval Midgut		1.2
Larval Hindgut		3.2
Larval Malpighian Tubules		3.5
Larval Fat Body		51.5
Larval Salivary Gland		4.4
Larval Trachea		3.775
Larval Carcass		7.5
Adult Head		4.5
Adult Eye		1.9
Adult Brain		2.8
Adult Thoracic-Abdominal Ganglion		2.5
Adult Crop		6.7
Adult Midgut		1.5
Adult Hindgut		3.3
Adult Malpighian Tubules		5.8
Adult Fat Body		4
Adult Salivary Gland		13.5
Adult Heart		0.85
Adult VirginFemale Spermatheca		1.6
Adult InseminatedFemale Spermatheca		2.1
Adult Ovary		3
Adult Testis		585.9
Adult Male Accessory Gland		2.4
Adult Carcass		2.1
Expression Level Scale		None Low Moderate High

Linear, scaled to Moderate expression
Tissue		Expression Level
Larval Central Nervous System		1.65
Larval Midgut		1.2
Larval Hindgut		3.2
Larval Malpighian Tubules		3.5
Larval Fat Body		51.5
Larval Salivary Gland		4.4
Larval Trachea		3.775
Larval Carcass		7.5
Adult Head		4.5
Adult Eye		1.9
Adult Brain		2.8
Adult Thoracic-Abdominal Ganglion		2.5
Adult Crop		6.7
Adult Midgut		1.5
Adult Hindgut		3.3
Adult Malpighian Tubules		5.8
Adult Fat Body		4
Adult Salivary Gland		13.5
Adult Heart		0.85
Adult VirginFemale Spermatheca		1.6
Adult InseminatedFemale Spermatheca		2.1
Adult Ovary		3
Adult Testis		(585.9)
Adult Male Accessory Gland		2.4
Adult Carcass		2.1
Expression Level Scale		None Low Moderate High

Linear, scaled to High level expression
Tissue		Expression Level
Larval Central Nervous System		1.65
Larval Midgut		1.2
Larval Hindgut		3.2
Larval Malpighian Tubules		3.5
Larval Fat Body		51.5
Larval Salivary Gland		4.4
Larval Trachea		3.775
Larval Carcass		7.5
Adult Head		4.5
Adult Eye		1.9
Adult Brain		2.8
Adult Thoracic-Abdominal Ganglion		2.5
Adult Crop		6.7
Adult Midgut		1.5
Adult Hindgut		3.3
Adult Malpighian Tubules		5.8
Adult Fat Body		4
Adult Salivary Gland		13.5
Adult Heart		0.85
Adult VirginFemale Spermatheca		1.6
Adult InseminatedFemale Spermatheca		2.1
Adult Ovary		3
Adult Testis		585.9
Adult Male Accessory Gland		2.4
Adult Carcass		2.1
Expression Level Scale		None Low Moderate High Very high

Linear, scaled to Very high expression
Tissue		Expression Level
Larval Central Nervous System		1.65
Larval Midgut		1.2
Larval Hindgut		3.2
Larval Malpighian Tubules		3.5
Larval Fat Body		51.5
Larval Salivary Gland		4.4
Larval Trachea		3.775
Larval Carcass		7.5
Adult Head		4.5
Adult Eye		1.9
Adult Brain		2.8
Adult Thoracic-Abdominal Ganglion		2.5
Adult Crop		6.7
Adult Midgut		1.5
Adult Hindgut		3.3
Adult Malpighian Tubules		5.8
Adult Fat Body		4
Adult Salivary Gland		13.5
Adult Heart		0.85
Adult VirginFemale Spermatheca		1.6
Adult InseminatedFemale Spermatheca		2.1
Adult Ovary		3
Adult Testis		585.9
Adult Male Accessory Gland		2.4
Adult Carcass		2.1
Expression Level Scale		Very high

log, scaled to maximum expression level
Tissue		Expression Level
Larval Central Nervous System		1.65
Larval Midgut		1.2
Larval Hindgut		3.2
Larval Malpighian Tubules		3.5
Larval Fat Body		51.5
Larval Salivary Gland		4.4
Larval Trachea		3.775
Larval Carcass		7.5
Adult Head		4.5
Adult Eye		1.9
Adult Brain		2.8
Adult Thoracic-Abdominal Ganglion		2.5
Adult Crop		6.7
Adult Midgut		1.5
Adult Hindgut		3.3
Adult Malpighian Tubules		5.8
Adult Fat Body		4
Adult Salivary Gland		13.5
Adult Heart		0.85
Adult VirginFemale Spermatheca		1.6
Adult InseminatedFemale Spermatheca		2.1
Adult Ovary		3
Adult Testis		585.9
Adult Male Accessory Gland		2.4
Adult Carcass		2.1
Expression Level Scale		None Low Moderate High Very high

log, scaled to Moderate expression
Tissue		Expression Level
Larval Central Nervous System		1.65
Larval Midgut		1.2
Larval Hindgut		3.2
Larval Malpighian Tubules		3.5
Larval Fat Body		51.5
Larval Salivary Gland		4.4
Larval Trachea		3.775
Larval Carcass		7.5
Adult Head		4.5
Adult Eye		1.9
Adult Brain		2.8
Adult Thoracic-Abdominal Ganglion		2.5
Adult Crop		6.7
Adult Midgut		1.5
Adult Hindgut		3.3
Adult Malpighian Tubules		5.8
Adult Fat Body		4
Adult Salivary Gland		13.5
Adult Heart		0.85
Adult VirginFemale Spermatheca		1.6
Adult InseminatedFemale Spermatheca		2.1
Adult Ovary		3
Adult Testis		585.9
Adult Male Accessory Gland		2.4
Adult Carcass		2.1
Expression Level Scale		None Low Moderate High

log, scaled to High level expression
Tissue		Expression Level
Larval Central Nervous System		1.65
Larval Midgut		1.2
Larval Hindgut		3.2
Larval Malpighian Tubules		3.5
Larval Fat Body		51.5
Larval Salivary Gland		4.4
Larval Trachea		3.775
Larval Carcass		7.5
Adult Head		4.5
Adult Eye		1.9
Adult Brain		2.8
Adult Thoracic-Abdominal Ganglion		2.5
Adult Crop		6.7
Adult Midgut		1.5
Adult Hindgut		3.3
Adult Malpighian Tubules		5.8
Adult Fat Body		4
Adult Salivary Gland		13.5
Adult Heart		0.85
Adult VirginFemale Spermatheca		1.6
Adult InseminatedFemale Spermatheca		2.1
Adult Ovary		3
Adult Testis		585.9
Adult Male Accessory Gland		2.4
Adult Carcass		2.1
Expression Level Scale		None Low Moderate High Very high

log, scaled to Very high expression
Tissue		Expression Level
Larval Central Nervous System		1.65
Larval Midgut		1.2
Larval Hindgut		3.2
Larval Malpighian Tubules		3.5
Larval Fat Body		51.5
Larval Salivary Gland		4.4
Larval Trachea		3.775
Larval Carcass		7.5
Adult Head		4.5
Adult Eye		1.9
Adult Brain		2.8
Adult Thoracic-Abdominal Ganglion		2.5
Adult Crop		6.7
Adult Midgut		1.5
Adult Hindgut		3.3
Adult Malpighian Tubules		5.8
Adult Fat Body		4
Adult Salivary Gland		13.5
Adult Heart		0.85
Adult VirginFemale Spermatheca		1.6
Adult InseminatedFemale Spermatheca		2.1
Adult Ovary		3
Adult Testis		585.9
Adult Male Accessory Gland		2.4
Adult Carcass		2.1
Expression Level Scale		None Low Moderate High Very high

Heatmap
Tissue		Expression Level
Larval Central Nervous System
Larval Midgut
Larval Hindgut
Larval Malpighian Tubules
Larval Fat Body
Larval Salivary Gland
Larval Trachea
Larval Carcass
Adult Head
Adult Eye
Adult Brain
Adult Thoracic-Abdominal Ganglion
Adult Crop
Adult Midgut
Adult Hindgut
Adult Malpighian Tubules
Adult Fat Body
Adult Salivary Gland
Adult Heart
Adult VirginFemale Spermatheca
Adult InseminatedFemale Spermatheca
Adult Ovary
Adult Testis
Adult Male Accessory Gland
Adult Carcass

FlyAtlas Organ/Tissue Expression, larval vs. adult
Larval Expression Level	Tissue	Adult Expression Level
NA	Head	4.5
NA	Eye	1.9
NA	Brain	2.8
1.65	Central Nervous System	NA
NA	Thoracic-Abdominal Ganglion	2.5
NA	Crop	6.7
1.2	Midgut	1.5
3.2	Hindgut	3.3
3.5	Malpighian Tubules	5.8
no informative data	Fat Body	4
4.4	Salivary Gland	no informative data
NA	Heart	0.85
3.775	Trachea	NA
NA	VirginFemale Spermatheca	1.6
NA	InseminatedFemale Spermatheca	2.1
NA	Ovary	3
NA	Testis	585.9
NA	Male Accessory Gland	2.4
7.5	Carcass	2.1

FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)

modENCODE Anatomy RNA-Seq

modENCODE Tissue Expression Data

(modENCODE_mRNA-Seq_tissues)

	Styles
	Linear
	Logarithmic
	Heatmap
	Scales
	gene max expression
	Moderate expression bin max
	High expression bin max
	Extremely high expression bin max

[download data (TSV)]

Guide to modENCODE expression level colors
	No/Extremely low expression (0 - 0)
	Very low expression (1 - 3)
	Low expression (4 - 10)
	Moderate expression (11 - 25)
	Moderately high expression (26 - 50)
	High expression (51 - 100)
	Very high expression (101 - 1000)
	Extremely high expression (>1000)

Linear, scaled to maximum expression level
Tissue		Expression Level
imaginal disc, larvae L3 wandering		20
central nervous system, larvae L3		0
central nervous system, pupae P8		0
head, virgin 1-day female		0
head, virgin 4-day female		0
head, virgin 20-day female		0
head, mated 1-day female		0
head, mated 4-day female		0
head, mated 20-day female		0
head, mated 1-day male		0
head, mated 4-day male		0
head, mated 20-day male		0
salivary gland, larvae L3 wandering		0
salivary gland, white prepupae		1
digestive system, larvae L3 wandering		0
digestive system, 1-day adult		0
digestive system, 4-day adult		1
digestive system, 20-day adult		0
fat body, larvae L3 wandering		0
fat body, white prepupae		5
fat body, pupae P8		4
carcass, larvae L3 wandering		0
carcass, 1-day adult		0
carcass, 4-day adult		0
carcass, 20-day adult		0
ovary, virgin 4-day female		0
ovary, mated 4-day female		0
testis, mated 4-day male		49
accessory gland, mated 4-day male		6
Expression Level Scale		Very low Low Moderate Moderately high High

Linear, scaled to Moderate expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		20
central nervous system, larvae L3		0
central nervous system, pupae P8		0
head, virgin 1-day female		0
head, virgin 4-day female		0
head, virgin 20-day female		0
head, mated 1-day female		0
head, mated 4-day female		0
head, mated 20-day female		0
head, mated 1-day male		0
head, mated 4-day male		0
head, mated 20-day male		0
salivary gland, larvae L3 wandering		0
salivary gland, white prepupae		1
digestive system, larvae L3 wandering		0
digestive system, 1-day adult		0
digestive system, 4-day adult		1
digestive system, 20-day adult		0
fat body, larvae L3 wandering		0
fat body, white prepupae		5
fat body, pupae P8		4
carcass, larvae L3 wandering		0
carcass, 1-day adult		0
carcass, 4-day adult		0
carcass, 20-day adult		0
ovary, virgin 4-day female		0
ovary, mated 4-day female		0
testis, mated 4-day male		(49)
accessory gland, mated 4-day male		6
Expression Level Scale		Very low Low Moderate Moderately high

Linear, scaled to High expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		20
central nervous system, larvae L3		0
central nervous system, pupae P8		0
head, virgin 1-day female		0
head, virgin 4-day female		0
head, virgin 20-day female		0
head, mated 1-day female		0
head, mated 4-day female		0
head, mated 20-day female		0
head, mated 1-day male		0
head, mated 4-day male		0
head, mated 20-day male		0
salivary gland, larvae L3 wandering		0
salivary gland, white prepupae		1
digestive system, larvae L3 wandering		0
digestive system, 1-day adult		0
digestive system, 4-day adult		1
digestive system, 20-day adult		0
fat body, larvae L3 wandering		0
fat body, white prepupae		5
fat body, pupae P8		4
carcass, larvae L3 wandering		0
carcass, 1-day adult		0
carcass, 4-day adult		0
carcass, 20-day adult		0
ovary, virgin 4-day female		0
ovary, mated 4-day female		0
testis, mated 4-day male		49
accessory gland, mated 4-day male		6
Expression Level Scale		Very low Low Moderate Moderately high High Very high

Linear, scaled to Extremely high expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		20
central nervous system, larvae L3		0
central nervous system, pupae P8		0
head, virgin 1-day female		0
head, virgin 4-day female		0
head, virgin 20-day female		0
head, mated 1-day female		0
head, mated 4-day female		0
head, mated 20-day female		0
head, mated 1-day male		0
head, mated 4-day male		0
head, mated 20-day male		0
salivary gland, larvae L3 wandering		0
salivary gland, white prepupae		1
digestive system, larvae L3 wandering		0
digestive system, 1-day adult		0
digestive system, 4-day adult		1
digestive system, 20-day adult		0
fat body, larvae L3 wandering		0
fat body, white prepupae		5
fat body, pupae P8		4
carcass, larvae L3 wandering		0
carcass, 1-day adult		0
carcass, 4-day adult		0
carcass, 20-day adult		0
ovary, virgin 4-day female		0
ovary, mated 4-day female		0
testis, mated 4-day male		49
accessory gland, mated 4-day male		6
Expression Level Scale		Extremely high

log, scaled to maximum expression level
Tissue		Expression Level
imaginal disc, larvae L3 wandering		20
central nervous system, larvae L3		0
central nervous system, pupae P8		0
head, virgin 1-day female		0
head, virgin 4-day female		0
head, virgin 20-day female		0
head, mated 1-day female		0
head, mated 4-day female		0
head, mated 20-day female		0
head, mated 1-day male		0
head, mated 4-day male		0
head, mated 20-day male		0
salivary gland, larvae L3 wandering		0
salivary gland, white prepupae		1
digestive system, larvae L3 wandering		0
digestive system, 1-day adult		0
digestive system, 4-day adult		1
digestive system, 20-day adult		0
fat body, larvae L3 wandering		0
fat body, white prepupae		5
fat body, pupae P8		4
carcass, larvae L3 wandering		0
carcass, 1-day adult		0
carcass, 4-day adult		0
carcass, 20-day adult		0
ovary, virgin 4-day female		0
ovary, mated 4-day female		0
testis, mated 4-day male		49
accessory gland, mated 4-day male		6
Expression Level Scale		Very low Low Moderate Moderately high High

log, scaled to Moderate expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		20
central nervous system, larvae L3		0
central nervous system, pupae P8		0
head, virgin 1-day female		0
head, virgin 4-day female		0
head, virgin 20-day female		0
head, mated 1-day female		0
head, mated 4-day female		0
head, mated 20-day female		0
head, mated 1-day male		0
head, mated 4-day male		0
head, mated 20-day male		0
salivary gland, larvae L3 wandering		0
salivary gland, white prepupae		1
digestive system, larvae L3 wandering		0
digestive system, 1-day adult		0
digestive system, 4-day adult		1
digestive system, 20-day adult		0
fat body, larvae L3 wandering		0
fat body, white prepupae		5
fat body, pupae P8		4
carcass, larvae L3 wandering		0
carcass, 1-day adult		0
carcass, 4-day adult		0
carcass, 20-day adult		0
ovary, virgin 4-day female		0
ovary, mated 4-day female		0
testis, mated 4-day male		(49)
accessory gland, mated 4-day male		6
Expression Level Scale		Very low Low Moderate Moderately high

log, scaled to High expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		20
central nervous system, larvae L3		0
central nervous system, pupae P8		0
head, virgin 1-day female		0
head, virgin 4-day female		0
head, virgin 20-day female		0
head, mated 1-day female		0
head, mated 4-day female		0
head, mated 20-day female		0
head, mated 1-day male		0
head, mated 4-day male		0
head, mated 20-day male		0
salivary gland, larvae L3 wandering		0
salivary gland, white prepupae		1
digestive system, larvae L3 wandering		0
digestive system, 1-day adult		0
digestive system, 4-day adult		1
digestive system, 20-day adult		0
fat body, larvae L3 wandering		0
fat body, white prepupae		5
fat body, pupae P8		4
carcass, larvae L3 wandering		0
carcass, 1-day adult		0
carcass, 4-day adult		0
carcass, 20-day adult		0
ovary, virgin 4-day female		0
ovary, mated 4-day female		0
testis, mated 4-day male		49
accessory gland, mated 4-day male		6
Expression Level Scale		Very low Low Moderate Moderately high High Very high

log, scaled to Extremely high expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		20
central nervous system, larvae L3		0
central nervous system, pupae P8		0
head, virgin 1-day female		0
head, virgin 4-day female		0
head, virgin 20-day female		0
head, mated 1-day female		0
head, mated 4-day female		0
head, mated 20-day female		0
head, mated 1-day male		0
head, mated 4-day male		0
head, mated 20-day male		0
salivary gland, larvae L3 wandering		0
salivary gland, white prepupae		1
digestive system, larvae L3 wandering		0
digestive system, 1-day adult		0
digestive system, 4-day adult		1
digestive system, 20-day adult		0
fat body, larvae L3 wandering		0
fat body, white prepupae		5
fat body, pupae P8		4
carcass, larvae L3 wandering		0
carcass, 1-day adult		0
carcass, 4-day adult		0
carcass, 20-day adult		0
ovary, virgin 4-day female		0
ovary, mated 4-day female		0
testis, mated 4-day male		49
accessory gland, mated 4-day male		6
Expression Level Scale		Very low Low Moderate Moderately high High Very high Extremely high

Heatmap
Tissue		Expression Level
imaginal disc, larvae L3 wandering
central nervous system, larvae L3
central nervous system, pupae P8
head, virgin 1-day female
head, virgin 4-day female
head, virgin 20-day female
head, mated 1-day female
head, mated 4-day female
head, mated 20-day female
head, mated 1-day male
head, mated 4-day male
head, mated 20-day male
salivary gland, larvae L3 wandering
salivary gland, white prepupae
digestive system, larvae L3 wandering
digestive system, 1-day adult
digestive system, 4-day adult
digestive system, 20-day adult
fat body, larvae L3 wandering
fat body, white prepupae
fat body, pupae P8
carcass, larvae L3 wandering
carcass, 1-day adult
carcass, 4-day adult
carcass, 20-day adult
ovary, virgin 4-day female
ovary, mated 4-day female
testis, mated 4-day male
accessory gland, mated 4-day male

modENCODE Development RNA-Seq

modENCODE Temporal Expression Data

(modENCODE_mRNA-Seq_U)

	Styles
	Linear
	Logarithmic
	Heatmap
	Scales
	gene max expression
	Moderate expression bin max
	High expression bin max
	Extremely high expression bin max

Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of no expression detected. Peak expression observed in adult male stages.
[download data (TSV)]

Guide to modENCODE expression level colors
	No/Extremely low expression (0 - 0)
	Very low expression (1 - 3)
	Low expression (4 - 10)
	Moderate expression (11 - 25)
	Moderately high expression (26 - 50)
	High expression (51 - 100)
	Very high expression (101 - 1000)
	Extremely high expression (>1000)

Linear, scaled to maximum expression level
Developmental Stage		Expression Level
embryo 00-02hr		0
embryo 02-04hr		0
embryo 04-06hr		0
embryo 06-08hr		0
embryo 08-10hr		0
embryo 10-12hr		0
embryo 12-14hr		0
embryo 14-16hr		0
embryo 16-18hr		0
embryo 18-20hr		0
embryo 20-22hr		0
embryo 22-24hr		0
larva L1		0
larva L2		0
larva L3 12hr old		0
larva L3 puffstage 1-2		2
larva L3 puffstage 3-6		7
larva L3 puffstage 7-9		9
white prepupae new		8
white prepupae 12hr		18
white prepupae 24hr		29
pupae 2d postWPP		36
pupae 3d postWPP		35
pupae 4d postWPP		27
adult male 01day		44
adult male 05day		58
adult male 30day		60
adult female 01day		0
adult female 05day		0
adult female 30day		0
Expression Level Scale		Very low Low Moderate Moderately high High

Linear, scaled to Moderate expression
Developmental Stage		Expression Level
embryo 00-02hr		0
embryo 02-04hr		0
embryo 04-06hr		0
embryo 06-08hr		0
embryo 08-10hr		0
embryo 10-12hr		0
embryo 12-14hr		0
embryo 14-16hr		0
embryo 16-18hr		0
embryo 18-20hr		0
embryo 20-22hr		0
embryo 22-24hr		0
larva L1		0
larva L2		0
larva L3 12hr old		0
larva L3 puffstage 1-2		2
larva L3 puffstage 3-6		7
larva L3 puffstage 7-9		9
white prepupae new		8
white prepupae 12hr		18
white prepupae 24hr		(29)
pupae 2d postWPP		(36)
pupae 3d postWPP		(35)
pupae 4d postWPP		(27)
adult male 01day		(44)
adult male 05day		(58)
adult male 30day		(60)
adult female 01day		0
adult female 05day		0
adult female 30day		0
Expression Level Scale		Very low Low Moderate Moderately high

Linear, scaled to High expression
Developmental Stage		Expression Level
embryo 00-02hr		0
embryo 02-04hr		0
embryo 04-06hr		0
embryo 06-08hr		0
embryo 08-10hr		0
embryo 10-12hr		0
embryo 12-14hr		0
embryo 14-16hr		0
embryo 16-18hr		0
embryo 18-20hr		0
embryo 20-22hr		0
embryo 22-24hr		0
larva L1		0
larva L2		0
larva L3 12hr old		0
larva L3 puffstage 1-2		2
larva L3 puffstage 3-6		7
larva L3 puffstage 7-9		9
white prepupae new		8
white prepupae 12hr		18
white prepupae 24hr		29
pupae 2d postWPP		36
pupae 3d postWPP		35
pupae 4d postWPP		27
adult male 01day		44
adult male 05day		58
adult male 30day		60
adult female 01day		0
adult female 05day		0
adult female 30day		0
Expression Level Scale		Very low Low Moderate Moderately high High Very high

Linear, scaled to Extremely high expression
Developmental Stage		Expression Level
embryo 00-02hr		0
embryo 02-04hr		0
embryo 04-06hr		0
embryo 06-08hr		0
embryo 08-10hr		0
embryo 10-12hr		0
embryo 12-14hr		0
embryo 14-16hr		0
embryo 16-18hr		0
embryo 18-20hr		0
embryo 20-22hr		0
embryo 22-24hr		0
larva L1		0
larva L2		0
larva L3 12hr old		0
larva L3 puffstage 1-2		2
larva L3 puffstage 3-6		7
larva L3 puffstage 7-9		9
white prepupae new		8
white prepupae 12hr		18
white prepupae 24hr		29
pupae 2d postWPP		36
pupae 3d postWPP		35
pupae 4d postWPP		27
adult male 01day		44
adult male 05day		58
adult male 30day		60
adult female 01day		0
adult female 05day		0
adult female 30day		0
Expression Level Scale		Extremely high

log, scaled to maximum expression level
Developmental Stage		Expression Level
embryo 00-02hr		0
embryo 02-04hr		0
embryo 04-06hr		0
embryo 06-08hr		0
embryo 08-10hr		0
embryo 10-12hr		0
embryo 12-14hr		0
embryo 14-16hr		0
embryo 16-18hr		0
embryo 18-20hr		0
embryo 20-22hr		0
embryo 22-24hr		0
larva L1		0
larva L2		0
larva L3 12hr old		0
larva L3 puffstage 1-2		2
larva L3 puffstage 3-6		7
larva L3 puffstage 7-9		9
white prepupae new		8
white prepupae 12hr		18
white prepupae 24hr		29
pupae 2d postWPP		36
pupae 3d postWPP		35
pupae 4d postWPP		27
adult male 01day		44
adult male 05day		58
adult male 30day		60
adult female 01day		0
adult female 05day		0
adult female 30day		0
Expression Level Scale		Very low Low Moderate Moderately high High

log, scaled to Moderate expression
Developmental Stage		Expression Level
embryo 00-02hr		0
embryo 02-04hr		0
embryo 04-06hr		0
embryo 06-08hr		0
embryo 08-10hr		0
embryo 10-12hr		0
embryo 12-14hr		0
embryo 14-16hr		0
embryo 16-18hr		0
embryo 18-20hr		0
embryo 20-22hr		0
embryo 22-24hr		0
larva L1		0
larva L2		0
larva L3 12hr old		0
larva L3 puffstage 1-2		2
larva L3 puffstage 3-6		7
larva L3 puffstage 7-9		9
white prepupae new		8
white prepupae 12hr		18
white prepupae 24hr		29
pupae 2d postWPP		(36)
pupae 3d postWPP		(35)
pupae 4d postWPP		27
adult male 01day		(44)
adult male 05day		(58)
adult male 30day		(60)
adult female 01day		0
adult female 05day		0
adult female 30day		0
Expression Level Scale		Very low Low Moderate Moderately high

log, scaled to High expression
Developmental Stage		Expression Level
embryo 00-02hr		0
embryo 02-04hr		0
embryo 04-06hr		0
embryo 06-08hr		0
embryo 08-10hr		0
embryo 10-12hr		0
embryo 12-14hr		0
embryo 14-16hr		0
embryo 16-18hr		0
embryo 18-20hr		0
embryo 20-22hr		0
embryo 22-24hr		0
larva L1		0
larva L2		0
larva L3 12hr old		0
larva L3 puffstage 1-2		2
larva L3 puffstage 3-6		7
larva L3 puffstage 7-9		9
white prepupae new		8
white prepupae 12hr		18
white prepupae 24hr		29
pupae 2d postWPP		36
pupae 3d postWPP		35
pupae 4d postWPP		27
adult male 01day		44
adult male 05day		58
adult male 30day		60
adult female 01day		0
adult female 05day		0
adult female 30day		0
Expression Level Scale		Very low Low Moderate Moderately high High Very high

log, scaled to Extremely high expression
Developmental Stage		Expression Level
embryo 00-02hr		0
embryo 02-04hr		0
embryo 04-06hr		0
embryo 06-08hr		0
embryo 08-10hr		0
embryo 10-12hr		0
embryo 12-14hr		0
embryo 14-16hr		0
embryo 16-18hr		0
embryo 18-20hr		0
embryo 20-22hr		0
embryo 22-24hr		0
larva L1		0
larva L2		0
larva L3 12hr old		0
larva L3 puffstage 1-2		2
larva L3 puffstage 3-6		7
larva L3 puffstage 7-9		9
white prepupae new		8
white prepupae 12hr		18
white prepupae 24hr		29
pupae 2d postWPP		36
pupae 3d postWPP		35
pupae 4d postWPP		27
adult male 01day		44
adult male 05day		58
adult male 30day		60
adult female 01day		0
adult female 05day		0
adult female 30day		0
Expression Level Scale		Very low Low Moderate Moderately high High Very high Extremely high

Heatmap
Developmental Stage		Expression Level
embryo 00-02hr
embryo 02-04hr
embryo 04-06hr
embryo 06-08hr
embryo 08-10hr
embryo 10-12hr
embryo 12-14hr
embryo 14-16hr
embryo 16-18hr
embryo 18-20hr
embryo 20-22hr
embryo 22-24hr
larva L1
larva L2
larva L3 12hr old
larva L3 puffstage 1-2
larva L3 puffstage 3-6
larva L3 puffstage 7-9
white prepupae new
white prepupae 12hr
white prepupae 24hr
pupae 2d postWPP
pupae 3d postWPP
pupae 4d postWPP
adult male 01day
adult male 05day
adult male 30day
adult female 01day
adult female 05day
adult female 30day

modENCODE Temporal Expression Data (Graveley et al., 2011)

modENCODE Cell Lines RNA-Seq

modENCODE Treatments RNA-Seq

modENCODE Treatment Expression Data

(modENCODE_mRNA-Seq_treatments)

	Styles
	Linear
	Logarithmic
	Heatmap
	Scales
	gene max expression
	Moderate expression bin max
	High expression bin max
	Extremely high expression bin max

[download data (TSV)]

Guide to modENCODE expression level colors
	No/Extremely low expression (0 - 0)
	Very low expression (1 - 3)
	Low expression (4 - 10)
	Moderate expression (11 - 25)
	Moderately high expression (26 - 50)
	High expression (51 - 100)
	Very high expression (101 - 1000)
	Extremely high expression (>1000)

Linear, scaled to maximum expression level
Treatment		Expression Level
extended cold, 4-day adult		1
cold shock, 4-day adult		1
heat shock, 4-day adult		3
Cadmium 50 mM 6 hrs, larvae L3		1
Cadmium 50 mM 12 hrs, larvae L3		2
Cadmium 50 mM 48 hrs, 4-day adult		2
Cadmium 100 mM 48 hrs, 4-day adult		3
Copper 0.5 mM 12 hrs, larvae L3		1
Copper 15 mM 48 hrs, 4-day adult		4
Zinc 5 mM 12 hrs, larvae L3		1
Zinc 4.5 mM 48 hrs, 4-day adult		7
Ethanol 2.5% 3 hrs, larvae L3		6
Ethanol 5% 3 hrs, larvae L3		0
Ethanol 10% 3 hrs, larvae L3		1
Caffeine 1.5 mg/ml 4 hrs, larvae L3		1
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		2
Caffeine 25 mg/ml 48 hrs, 4-day adult		1
Paraquat 5 mM 48 hrs, 4-day adult		8
Paraquat 10 mM 48 hrs, 4-day adult		9
Rotenone 2 μg 12 hrs, larvae L3		1
Rotenone 8 μg 12 hrs, larvae L3		1
Expression Level Scale		Very low Low Moderate

Linear, scaled to Moderate expression
Treatment		Expression Level
extended cold, 4-day adult		1
cold shock, 4-day adult		1
heat shock, 4-day adult		3
Cadmium 50 mM 6 hrs, larvae L3		1
Cadmium 50 mM 12 hrs, larvae L3		2
Cadmium 50 mM 48 hrs, 4-day adult		2
Cadmium 100 mM 48 hrs, 4-day adult		3
Copper 0.5 mM 12 hrs, larvae L3		1
Copper 15 mM 48 hrs, 4-day adult		4
Zinc 5 mM 12 hrs, larvae L3		1
Zinc 4.5 mM 48 hrs, 4-day adult		7
Ethanol 2.5% 3 hrs, larvae L3		6
Ethanol 5% 3 hrs, larvae L3		0
Ethanol 10% 3 hrs, larvae L3		1
Caffeine 1.5 mg/ml 4 hrs, larvae L3		1
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		2
Caffeine 25 mg/ml 48 hrs, 4-day adult		1
Paraquat 5 mM 48 hrs, 4-day adult		8
Paraquat 10 mM 48 hrs, 4-day adult		9
Rotenone 2 μg 12 hrs, larvae L3		1
Rotenone 8 μg 12 hrs, larvae L3		1
Expression Level Scale		Very low Low Moderate Moderately high

Linear, scaled to High expression
Treatment		Expression Level
extended cold, 4-day adult		1
cold shock, 4-day adult		1
heat shock, 4-day adult		3
Cadmium 50 mM 6 hrs, larvae L3		1
Cadmium 50 mM 12 hrs, larvae L3		2
Cadmium 50 mM 48 hrs, 4-day adult		2
Cadmium 100 mM 48 hrs, 4-day adult		3
Copper 0.5 mM 12 hrs, larvae L3		1
Copper 15 mM 48 hrs, 4-day adult		4
Zinc 5 mM 12 hrs, larvae L3		1
Zinc 4.5 mM 48 hrs, 4-day adult		7
Ethanol 2.5% 3 hrs, larvae L3		6
Ethanol 5% 3 hrs, larvae L3		0
Ethanol 10% 3 hrs, larvae L3		1
Caffeine 1.5 mg/ml 4 hrs, larvae L3		1
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		2
Caffeine 25 mg/ml 48 hrs, 4-day adult		1
Paraquat 5 mM 48 hrs, 4-day adult		8
Paraquat 10 mM 48 hrs, 4-day adult		9
Rotenone 2 μg 12 hrs, larvae L3		1
Rotenone 8 μg 12 hrs, larvae L3		1
Expression Level Scale		Very low Low Moderate Moderately high High Very high

Linear, scaled to Extremely high expression
Treatment		Expression Level
extended cold, 4-day adult		1
cold shock, 4-day adult		1
heat shock, 4-day adult		3
Cadmium 50 mM 6 hrs, larvae L3		1
Cadmium 50 mM 12 hrs, larvae L3		2
Cadmium 50 mM 48 hrs, 4-day adult		2
Cadmium 100 mM 48 hrs, 4-day adult		3
Copper 0.5 mM 12 hrs, larvae L3		1
Copper 15 mM 48 hrs, 4-day adult		4
Zinc 5 mM 12 hrs, larvae L3		1
Zinc 4.5 mM 48 hrs, 4-day adult		7
Ethanol 2.5% 3 hrs, larvae L3		6
Ethanol 5% 3 hrs, larvae L3		0
Ethanol 10% 3 hrs, larvae L3		1
Caffeine 1.5 mg/ml 4 hrs, larvae L3		1
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		2
Caffeine 25 mg/ml 48 hrs, 4-day adult		1
Paraquat 5 mM 48 hrs, 4-day adult		8
Paraquat 10 mM 48 hrs, 4-day adult		9
Rotenone 2 μg 12 hrs, larvae L3		1
Rotenone 8 μg 12 hrs, larvae L3		1
Expression Level Scale		Extremely high

log, scaled to maximum expression level
Treatment		Expression Level
extended cold, 4-day adult		1
cold shock, 4-day adult		1
heat shock, 4-day adult		3
Cadmium 50 mM 6 hrs, larvae L3		1
Cadmium 50 mM 12 hrs, larvae L3		2
Cadmium 50 mM 48 hrs, 4-day adult		2
Cadmium 100 mM 48 hrs, 4-day adult		3
Copper 0.5 mM 12 hrs, larvae L3		1
Copper 15 mM 48 hrs, 4-day adult		4
Zinc 5 mM 12 hrs, larvae L3		1
Zinc 4.5 mM 48 hrs, 4-day adult		7
Ethanol 2.5% 3 hrs, larvae L3		6
Ethanol 5% 3 hrs, larvae L3		0
Ethanol 10% 3 hrs, larvae L3		1
Caffeine 1.5 mg/ml 4 hrs, larvae L3		1
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		2
Caffeine 25 mg/ml 48 hrs, 4-day adult		1
Paraquat 5 mM 48 hrs, 4-day adult		8
Paraquat 10 mM 48 hrs, 4-day adult		9
Rotenone 2 μg 12 hrs, larvae L3		1
Rotenone 8 μg 12 hrs, larvae L3		1
Expression Level Scale		Very low Low Moderate

log, scaled to Moderate expression
Treatment		Expression Level
extended cold, 4-day adult		1
cold shock, 4-day adult		1
heat shock, 4-day adult		3
Cadmium 50 mM 6 hrs, larvae L3		1
Cadmium 50 mM 12 hrs, larvae L3		2
Cadmium 50 mM 48 hrs, 4-day adult		2
Cadmium 100 mM 48 hrs, 4-day adult		3
Copper 0.5 mM 12 hrs, larvae L3		1
Copper 15 mM 48 hrs, 4-day adult		4
Zinc 5 mM 12 hrs, larvae L3		1
Zinc 4.5 mM 48 hrs, 4-day adult		7
Ethanol 2.5% 3 hrs, larvae L3		6
Ethanol 5% 3 hrs, larvae L3		0
Ethanol 10% 3 hrs, larvae L3		1
Caffeine 1.5 mg/ml 4 hrs, larvae L3		1
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		2
Caffeine 25 mg/ml 48 hrs, 4-day adult		1
Paraquat 5 mM 48 hrs, 4-day adult		8
Paraquat 10 mM 48 hrs, 4-day adult		9
Rotenone 2 μg 12 hrs, larvae L3		1
Rotenone 8 μg 12 hrs, larvae L3		1
Expression Level Scale		Very low Low Moderate Moderately high

log, scaled to High expression
Treatment		Expression Level
extended cold, 4-day adult		1
cold shock, 4-day adult		1
heat shock, 4-day adult		3
Cadmium 50 mM 6 hrs, larvae L3		1
Cadmium 50 mM 12 hrs, larvae L3		2
Cadmium 50 mM 48 hrs, 4-day adult		2
Cadmium 100 mM 48 hrs, 4-day adult		3
Copper 0.5 mM 12 hrs, larvae L3		1
Copper 15 mM 48 hrs, 4-day adult		4
Zinc 5 mM 12 hrs, larvae L3		1
Zinc 4.5 mM 48 hrs, 4-day adult		7
Ethanol 2.5% 3 hrs, larvae L3		6
Ethanol 5% 3 hrs, larvae L3		0
Ethanol 10% 3 hrs, larvae L3		1
Caffeine 1.5 mg/ml 4 hrs, larvae L3		1
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		2
Caffeine 25 mg/ml 48 hrs, 4-day adult		1
Paraquat 5 mM 48 hrs, 4-day adult		8
Paraquat 10 mM 48 hrs, 4-day adult		9
Rotenone 2 μg 12 hrs, larvae L3		1
Rotenone 8 μg 12 hrs, larvae L3		1
Expression Level Scale		Very low Low Moderate Moderately high High Very high

log, scaled to Extremely high expression
Treatment		Expression Level
extended cold, 4-day adult		1
cold shock, 4-day adult		1
heat shock, 4-day adult		3
Cadmium 50 mM 6 hrs, larvae L3		1
Cadmium 50 mM 12 hrs, larvae L3		2
Cadmium 50 mM 48 hrs, 4-day adult		2
Cadmium 100 mM 48 hrs, 4-day adult		3
Copper 0.5 mM 12 hrs, larvae L3		1
Copper 15 mM 48 hrs, 4-day adult		4
Zinc 5 mM 12 hrs, larvae L3		1
Zinc 4.5 mM 48 hrs, 4-day adult		7
Ethanol 2.5% 3 hrs, larvae L3		6
Ethanol 5% 3 hrs, larvae L3		0
Ethanol 10% 3 hrs, larvae L3		1
Caffeine 1.5 mg/ml 4 hrs, larvae L3		1
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		2
Caffeine 25 mg/ml 48 hrs, 4-day adult		1
Paraquat 5 mM 48 hrs, 4-day adult		8
Paraquat 10 mM 48 hrs, 4-day adult		9
Rotenone 2 μg 12 hrs, larvae L3		1
Rotenone 8 μg 12 hrs, larvae L3		1
Expression Level Scale		Very low Low Moderate Moderately high High Very high Extremely high

Heatmap
Treatment		Expression Level
extended cold, 4-day adult
cold shock, 4-day adult
heat shock, 4-day adult
Cadmium 50 mM 6 hrs, larvae L3
Cadmium 50 mM 12 hrs, larvae L3
Cadmium 50 mM 48 hrs, 4-day adult
Cadmium 100 mM 48 hrs, 4-day adult
Copper 0.5 mM 12 hrs, larvae L3
Copper 15 mM 48 hrs, 4-day adult
Zinc 5 mM 12 hrs, larvae L3
Zinc 4.5 mM 48 hrs, 4-day adult
Ethanol 2.5% 3 hrs, larvae L3
Ethanol 5% 3 hrs, larvae L3
Ethanol 10% 3 hrs, larvae L3
Caffeine 1.5 mg/ml 4 hrs, larvae L3
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
Caffeine 25 mg/ml 48 hrs, 4-day adult
Paraquat 5 mM 48 hrs, 4-day adult
Paraquat 10 mM 48 hrs, 4-day adult
Rotenone 2 μg 12 hrs, larvae L3
Rotenone 8 μg 12 hrs, larvae L3

Expression Clusters

A cluster of genes with similar mRNA expression dynamics across development.

(The modENCODE Consortium, 2010, Graveley et al., 2011)

External Data & Images

Linkouts

BDGP expression data

•

AT02886

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

•

FBgn0037862

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

•

CG4706-RA

Alleles & Phenotypes

Summary of Allele Phenotypes

Lethality

Allele

viable, with Scer\GAL4^pnr-MD237

CG4706^GD11401

Phenotype manifest in

Allele

Classical Alleles ( 1 )

For All Classical Alleles Show

Allele of CG4706	Class	Mutagen	Stocks	Known lesion
CG4706^MB05145			1	--

Alleles Carried on Transgenic Constructs ( 3 )

For All Alleles Carried on Transgenic Constructs Show

Allele of CG4706	Mutagen	Stocks	Known lesion
CG4706^GD11401	in vitro construct - RNAi in vitro construct - regulatory fusion	2	Yes
CG4706^KK105375	in vitro construct - RNAi in vitro construct - regulatory fusion	1	Yes
CG4706^NIG.4706R	in vitro construct - RNAi in vitro construct - regulatory fusion	0	Yes

Aneuploid Aberrations

Disrupted in

Df(3R)Exel7306

(Ryder, 2004.4.26)

Transgenic Constructs & Insertions

Transgenic Constructs

Type of construct

Name

Expression data

UAS construct

P{GD11401}

P{KK105375}

P{NIG.4706R}

Insertions

Type of insertions

Name

Expression data

insertion of enhancer trap binary system

Mi{ET1}CG4706^MB05145

Gene Ontology: Function, Process & Cellular Component ( 6 unique terms )

Terms Based on Experimental Evidence ( 2 terms )

Molecular Function ( 0 terms)

Biological Process

CV term

Evidence

References

multicellular organism reproduction

inferred from expression pattern

(Findlay et al., 2009)

Cellular Component

CV term

Evidence

References

extracellular space

inferred from direct assay

(Findlay et al., 2009)

Terms Based on Predictions or Assertions ( 4 terms )

Molecular Function

CV term

Evidence

References

4 iron, 4 sulfur cluster binding

inferred from electronic annotation with InterPro:IPR006248

(FlyBase Curators et al., 2004-)

aconitate hydratase activity

inferred from sequence or structural similarity with NCBI_gi:4501867

(FlyBase, 1992-)

Biological Process

CV term

Evidence

References

tricarboxylic acid cycle

inferred from sequence or structural similarity with UniProtKB:Q99798

(Sardiello et al., 2003.6.11)

Cellular Component

CV term

Evidence

References

mitochondrion

inferred from sequence or structural similarity with NCBI_gi:4501867

(FlyBase, 1992-)

inferred from sequence or structural similarity with UniProtKB:Q99798

(Sardiello et al., 2003.6.11)

Sequence Ontology: Class of Gene

nuclear_gene

protein_coding_gene

Interactions & Pathways

Summary of Physical Interactions

Summary of Genetic Interactions

Interacts with

Please look at the allele data for full details of the genetic interactions

CG4706 allele

Gene

References

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

•

FBgn0037862

InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets.

•

41326

Orthologs

OrthoDB Orthologs (36) - based on analysis using Dmel annotation version 5.41

OrthoDB Ortholog Groups

OrthoDB orthology group searches

(Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288)

Drosophila inclusive ortholog search

EOG63JCQ3

Dipteran inclusive ortholog search

No orthologs identified

Insect inclusive ortholog search

EOG6BRVFP

Arthropod inclusive ortholog search

EOG6VT4C6

Metazoa inclusive ortholog search

EOG6DC66G

Orthologs in Drosophila Species (EOG63JCQ3)

Organism

Common Name

Gene

AAA Syntenic Ortholog

Multiple Dmel Genes in this Orthologous Group

Drosophila melanogaster

fruit fly

Drosophila simulans

Drosophila sechellia

Drosophila erecta

Drosophila yakuba

Drosophila ananassae

Drosophila pseudoobscura pseudoobscura

Dpse\GA18372

Drosophila persimilis

Dper\GL12556

Drosophila willistoni

Dwil\GK13996

Drosophila virilis

Dvir\GJ23339

Drosophila mojavensis

Dmoj\GI10118

Drosophila grimshawi

Dgri\GH19424

Orthologs in non-Drosophila Dipterans (None identified)

No non-Drosophilid orthologies identified

Orthologs in non-Dipteran Insects (EOG6BRVFP)

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Apis mellifera

Western honey bee

Amel\LOC408446

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG000897

Acromyrmex echinatior

Panamanian leafcutter ant

Aech\AECH16482

Atta cephalotes

Leafcutter ant

Acep\ACEP10786

Camponotus floridanus

Florida carpenter ant

Cflo\CFLO21234

Harpegnathos saltator

Jerdons jumping ant

Hsal\HSAL12380

Linepithema humile

Argentine ant

Lhum\LH19462

Pogonomyrmex barbatus

Red harvester ant

Pbar\PB22339

Solenopsis invicta

Red fire ant

Sinv\SINV18335

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI010059

Bombyx mori

Silkmoth

Bmor\BGIBMGA007121

Pediculus humanus

Human body louse

Phum\PHUM303350

Tribolium castaneum

Red flour beetle

Tcas\TC005725

Orthologs in non-Insect Arthropods (EOG6VT4C6)

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Daphnia pulex

Water flea

Dpux\JGI_V11_306094

Ixodes scapularis

Deer tick

Isca\ISCW016071

Orthologs in non-Arthropod Metazoa (EOG6DC66G)

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Caenorhabditis elegans

Nematode

Cele\aco-2

Strongylocentrotus purpuratus

Purple sea urchin

Spur\SPU_005839gn

Strongylocentrotus purpuratus

Purple sea urchin

Spur\SPU_008069gn

Danio rerio

Zebrafish

Drer\aco2

Xenopus tropicalis

Western clawed frog

Xtro\aco2

Gallus gallus

Domestic chicken

Ggal\ACO2

Mus musculus

House mouse

Mmus\Aco2

Rattus norvegicus

Norway rat

Rnor\Aco2

Homo sapiens

Human

Hsap\ACO2

Human Orthologs (1)

Gene

OMIM

HGNC

Hsap\ACO2

AAA Orthologs (11) based on analysis using Dmel annotation version 4.3

Organism

Gene

Drosophila simulans

Drosophila sechellia

Drosophila erecta

Drosophila yakuba

Drosophila ananassae

Drosophila pseudoobscura pseudoobscura

Dpse\GA18372

Drosophila persimilis

Dper\GL12556

Drosophila willistoni

Dwil\GK13996

Drosophila virilis

Dvir\GJ23339

Drosophila mojavensis

Dmoj\GI10118

Drosophila grimshawi

Dgri\GH19424

Stocks & Reagents

Stocks Listed in FlyBase ( 4 )

Bloomington

24609

w¹¹¹⁸; Mi{ET1}CG4706^MB05145

VDRC

v102843

P{KK105375}VIE-260B

v34888

w¹¹¹⁸; P{GD11401}v34888

v34889

w¹¹¹⁸; P{GD11401}v34889

Genomic Clones ( 1 )

BACR48M21

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones ( 11 )

Please Note

This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA Clones, Fully Sequenced

BDGP DGC clones

AT02886

Other clones

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi & Array Information

Linkouts

DRSC - Results from RNAi screens.

•

FBgn0037862

GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents

•

41326

Antibody Information

Other Information

Discoverer

Etymology

Identification

Relationship to Other Genes

Source for database identity of

Source for database merge of

Additional comments

The CG4706 gene may have been derived from the Acon gene by retroposition.

(Bai et al., 2007)

The CG4706 gene may be derived from the Acon gene by retroposition.

(Betran et al., 2002)

Other Comments

External Crossreferences & Linkouts

Sequence Crossreferences

RefSeq (Transcripts)

•

NM_141785

RefSeq (Proteins)

•

NP_650042

DDBJ / EMBL / GenBank

•

Entrez Gene - A searchable database of RefSeq genes.

•

41326

UniProtKB/TrEMBL

•

Q8T4D6

Other Crossreferences

InterPro domains - A database of protein families, domains, and functional sites

•

Aconitase A/isopropylmalate dehydratase small subunit, swivel (IPR000573)

Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha (IPR001030)

Aconitase, mitochondrial-like (IPR006248)

Aconitase family, 4Fe-4S cluster binding site (IPR018136)

Aconitase/3-isopropylmalate dehydratase, swivel (IPR015928)

Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha, subdomain 1/3 (IPR015931)

Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha, subdomain 2 (IPR015932)

Aconitase/isopropylmalate dehydratase (IPR015937)

MitoDrome - A database of annotated Dmel nuclear genes encoding mitochondrial proteins

•

MTDROME04706

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

•

AT02886

Linkouts

DroID - A comprehensive database of gene and protein interactions.

•

FBgn0037862

DRSC - Results from RNAi screens.

•

FBgn0037862

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

•

FBgn0037862

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

•

CG4706-RA

FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans

•

FBgn0037862

GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents

•

41326

InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets.

•

41326

modMine - Data generated by the modENCODE project.

•

FBgn0037862

Synonyms & Secondary IDs ( 1 )

Reported As

Symbol Synonym

CG4706

(Langille and Clark, 2007, Dorus et al., 2006, Zhou et al., 2008, Takemori and Yamamoto, 2009, Dorus et al., 2008, Findlay et al., 2009, Keleman et al., 2009.8.5, Bai et al., 2007, Bai et al., 2009, Wasbrough et al., 2010, Bai et al., 2007, Japanese National Institute of Genetics, 2012.5.21)

Name Synonym

Secondary FlyBase IDs

References ( 29 )

Generate a list of

All references relating to this gene ( 29 )

List References by type

Recent research papers ( 1 )

Díaz-Castillo and Ranz, 2012, Mol. Biol. Evol. 29(9): 2105--2108: Nuclear chromosome dynamics in the Drosophila male germ line contribute to the nonrandom genomic distribution of retrogenes. [FBrf0219274]

Show all research papers ...