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Gene Dmel\Arfip

General Information
Symbol	Dmel\Arfip	Species	D. melanogaster
Name	Arfaptin	Annotation symbol	CG17184
Feature type	protein_coding_gene	FlyBase ID	FBgn0037884
Gene Model Status	Current	Stock availability	7 publicly available
Genomic Location
Chromosome (arm)	3R	Recombination map
Cytogenetic map	86D8-86D8	Sequence location	3R:7,058,151..7,060,735 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Arfaptin is referred to in FlyBase by the symbol Dmel\Arfip (CG17184, FBgn0037884). It is a protein_coding_gene from Drosophila melanogaster. An electronic pipeline based on InterPro domains suggests that it has the molecular function: protein domain specific binding. There is experimental evidence that it is involved in the biological process: behavioral response to ethanol. 9 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: Arfaptin homology (AH) domain; Arfaptin homology (AH) domain/BAR domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression. Peak expression observed within 00-18 hour embryonic stages, during late larval stages, at stages throughout the pupal period, in stages of adults of both sexes. Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult tissues/organs expressed at moderate levels. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, larval fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male reproductive system, larval carcass. Comments on Affy2 ProbeSet: ProbeSet 1629848_s_at completely aligns to an exonic region common to each of the 2 FlyBase-annotated transcript isoforms of CG17184. Gene sequence location is 3R:7058151..7060735.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02	Controlled Vocabulary Terms behavioral response to ethanol
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 86D8-86D8   Limits computationally determined from genome sequence between P{EP}EP3340EP3340 and P{PZ}tho1&P{PZ}l(3)0462905275
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Arfip for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.49 Low-frequency RNA-Seq exon junction(s) not annotated.
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Arfip-RA FBtr0082364  NM_141801   2004   355
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Arfip-PA   FBpp0081840   38.8   355   7.66     NP_650058   AAF54618
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Arfaptin homology (AH) domain (IPR010504) Arfaptin homology (AH) domain/BAR domain (IPR027267)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA990787   AE014297 AAF54618   AI108632   AI512315   AI514786   AW943697   BG637068   BI163707   BI212997   BI214814   BI356588   BI371010   BI482233   BI483280   BI485852   BI577144   BI580210   BI637858   BT004867 AAO45223   BT023858   BX066688   CL868525   CO192708   CO314459   CO333190   CZ473812   CZ473813   EC090725   EC214209   EV594134
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9VGQ8
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult tissues/organs expressed at moderate levels. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, larval fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male reproductive system, larval carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    402.775 Larval Midgut    259.5 Larval Hindgut    300.1 Larval Malpighian Tubules    122.7 Larval Fat Body    115 Larval Salivary Gland    304.3 Larval Trachea    146.5 Larval Carcass    294.175 Adult Head    129.4 Adult Eye    95.375 Adult Brain    308.2 Adult Thoracic-Abdominal Ganglion    321.4 Adult Crop    176.5 Adult Midgut    150.9 Adult Hindgut    174.1 Adult Malpighian Tubules    128.3 Adult Fat Body    86.5 Adult Salivary Gland    202.6 Adult Heart    98.175 Adult VirginFemale Spermatheca    137.1 Adult InseminatedFemale Spermatheca    167.5 Adult Ovary    439.9 Adult Testis    178.4 Adult Male Accessory Gland    140.8 Adult Carcass    89.8 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    402.775 Larval Midgut    259.5 Larval Hindgut    300.1 Larval Malpighian Tubules    122.7 Larval Fat Body    115 Larval Salivary Gland    304.3 Larval Trachea    146.5 Larval Carcass    294.175 Adult Head    129.4 Adult Eye    95.375 Adult Brain    308.2 Adult Thoracic-Abdominal Ganglion    321.4 Adult Crop    176.5 Adult Midgut    150.9 Adult Hindgut    174.1 Adult Malpighian Tubules    128.3 Adult Fat Body    86.5 Adult Salivary Gland    202.6 Adult Heart    98.175 Adult VirginFemale Spermatheca    137.1 Adult InseminatedFemale Spermatheca    167.5 Adult Ovary    439.9 Adult Testis    178.4 Adult Male Accessory Gland    140.8 Adult Carcass    89.8 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    402.775 Larval Midgut    259.5 Larval Hindgut    300.1 Larval Malpighian Tubules    122.7 Larval Fat Body    115 Larval Salivary Gland    304.3 Larval Trachea    146.5 Larval Carcass    294.175 Adult Head    129.4 Adult Eye    95.375 Adult Brain    308.2 Adult Thoracic-Abdominal Ganglion    321.4 Adult Crop    176.5 Adult Midgut    150.9 Adult Hindgut    174.1 Adult Malpighian Tubules    128.3 Adult Fat Body    86.5 Adult Salivary Gland    202.6 Adult Heart    98.175 Adult VirginFemale Spermatheca    137.1 Adult InseminatedFemale Spermatheca    167.5 Adult Ovary    439.9 Adult Testis    178.4 Adult Male Accessory Gland    140.8 Adult Carcass    89.8 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    402.775 Larval Midgut    259.5 Larval Hindgut    300.1 Larval Malpighian Tubules    122.7 Larval Fat Body    115 Larval Salivary Gland    304.3 Larval Trachea    146.5 Larval Carcass    294.175 Adult Head    129.4 Adult Eye    95.375 Adult Brain    308.2 Adult Thoracic-Abdominal Ganglion    321.4 Adult Crop    176.5 Adult Midgut    150.9 Adult Hindgut    174.1 Adult Malpighian Tubules    128.3 Adult Fat Body    86.5 Adult Salivary Gland    202.6 Adult Heart    98.175 Adult VirginFemale Spermatheca    137.1 Adult InseminatedFemale Spermatheca    167.5 Adult Ovary    439.9 Adult Testis    178.4 Adult Male Accessory Gland    140.8 Adult Carcass    89.8 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    402.775 Larval Midgut    259.5 Larval Hindgut    300.1 Larval Malpighian Tubules    122.7 Larval Fat Body    115 Larval Salivary Gland    304.3 Larval Trachea    146.5 Larval Carcass    294.175 Adult Head    129.4 Adult Eye    95.375 Adult Brain    308.2 Adult Thoracic-Abdominal Ganglion    321.4 Adult Crop    176.5 Adult Midgut    150.9 Adult Hindgut    174.1 Adult Malpighian Tubules    128.3 Adult Fat Body    86.5 Adult Salivary Gland    202.6 Adult Heart    98.175 Adult VirginFemale Spermatheca    137.1 Adult InseminatedFemale Spermatheca    167.5 Adult Ovary    439.9 Adult Testis    178.4 Adult Male Accessory Gland    140.8 Adult Carcass    89.8 Expression Level Scale  None   Low   Moderate   High  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    402.775 Larval Midgut    259.5 Larval Hindgut    300.1 Larval Malpighian Tubules    122.7 Larval Fat Body    115 Larval Salivary Gland    304.3 Larval Trachea    146.5 Larval Carcass    294.175 Adult Head    129.4 Adult Eye    95.375 Adult Brain    308.2 Adult Thoracic-Abdominal Ganglion    321.4 Adult Crop    176.5 Adult Midgut    150.9 Adult Hindgut    174.1 Adult Malpighian Tubules    128.3 Adult Fat Body    86.5 Adult Salivary Gland    202.6 Adult Heart    98.175 Adult VirginFemale Spermatheca    137.1 Adult InseminatedFemale Spermatheca    167.5 Adult Ovary    439.9 Adult Testis    178.4 Adult Male Accessory Gland    140.8 Adult Carcass    89.8 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    402.775 Larval Midgut    259.5 Larval Hindgut    300.1 Larval Malpighian Tubules    122.7 Larval Fat Body    115 Larval Salivary Gland    304.3 Larval Trachea    146.5 Larval Carcass    294.175 Adult Head    129.4 Adult Eye    95.375 Adult Brain    308.2 Adult Thoracic-Abdominal Ganglion    321.4 Adult Crop    176.5 Adult Midgut    150.9 Adult Hindgut    174.1 Adult Malpighian Tubules    128.3 Adult Fat Body    86.5 Adult Salivary Gland    202.6 Adult Heart    98.175 Adult VirginFemale Spermatheca    137.1 Adult InseminatedFemale Spermatheca    167.5 Adult Ovary    439.9 Adult Testis    178.4 Adult Male Accessory Gland    140.8 Adult Carcass    89.8 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    402.775 Larval Midgut    259.5 Larval Hindgut    300.1 Larval Malpighian Tubules    122.7 Larval Fat Body    115 Larval Salivary Gland    304.3 Larval Trachea    146.5 Larval Carcass    294.175 Adult Head    129.4 Adult Eye    95.375 Adult Brain    308.2 Adult Thoracic-Abdominal Ganglion    321.4 Adult Crop    176.5 Adult Midgut    150.9 Adult Hindgut    174.1 Adult Malpighian Tubules    128.3 Adult Fat Body    86.5 Adult Salivary Gland    202.6 Adult Heart    98.175 Adult VirginFemale Spermatheca    137.1 Adult InseminatedFemale Spermatheca    167.5 Adult Ovary    439.9 Adult Testis    178.4 Adult Male Accessory Gland    140.8 Adult Carcass    89.8 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    129.4   NA  Eye    95.375   NA  Brain    308.2   402.775  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    321.4   NA  Crop    176.5   259.5  Midgut    150.9   300.1  Hindgut    174.1   122.7  Malpighian Tubules    128.3   115  Fat Body    86.5   304.3  Salivary Gland    202.6   NA  Heart    98.175   146.5  Trachea    NA   NA  VirginFemale Spermatheca    137.1   NA  InseminatedFemale Spermatheca    167.5   NA  Ovary    439.9   NA  Testis    178.4   NA  Male Accessory Gland    140.8   294.175  Carcass    89.8 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    22 central nervous system, larvae L3    21 central nervous system, pupae P8    19 head, virgin 1-day female    6 head, virgin 4-day female    7 head, virgin 20-day female    9 head, mated 1-day female    6 head, mated 4-day female    6 head, mated 20-day female    7 head, mated 1-day male    11 head, mated 4-day male    12 head, mated 20-day male    13 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    4 digestive system, larvae L3 wandering    8 digestive system, 1-day adult    6 digestive system, 4-day adult    7 digestive system, 20-day adult    7 fat body, larvae L3 wandering    2 fat body, white prepupae    6 fat body, pupae P8    12 carcass, larvae L3 wandering    14 carcass, 1-day adult    4 carcass, 4-day adult    5 carcass, 20-day adult    5 ovary, virgin 4-day female    29 ovary, mated 4-day female    22 testis, mated 4-day male    12 accessory gland, mated 4-day male    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    22 central nervous system, larvae L3    21 central nervous system, pupae P8    19 head, virgin 1-day female    6 head, virgin 4-day female    7 head, virgin 20-day female    9 head, mated 1-day female    6 head, mated 4-day female    6 head, mated 20-day female    7 head, mated 1-day male    11 head, mated 4-day male    12 head, mated 20-day male    13 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    4 digestive system, larvae L3 wandering    8 digestive system, 1-day adult    6 digestive system, 4-day adult    7 digestive system, 20-day adult    7 fat body, larvae L3 wandering    2 fat body, white prepupae    6 fat body, pupae P8    12 carcass, larvae L3 wandering    14 carcass, 1-day adult    4 carcass, 4-day adult    5 carcass, 20-day adult    5 ovary, virgin 4-day female  (29) ovary, mated 4-day female    22 testis, mated 4-day male    12 accessory gland, mated 4-day male    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    22 central nervous system, larvae L3    21 central nervous system, pupae P8    19 head, virgin 1-day female    6 head, virgin 4-day female    7 head, virgin 20-day female    9 head, mated 1-day female    6 head, mated 4-day female    6 head, mated 20-day female    7 head, mated 1-day male    11 head, mated 4-day male    12 head, mated 20-day male    13 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    4 digestive system, larvae L3 wandering    8 digestive system, 1-day adult    6 digestive system, 4-day adult    7 digestive system, 20-day adult    7 fat body, larvae L3 wandering    2 fat body, white prepupae    6 fat body, pupae P8    12 carcass, larvae L3 wandering    14 carcass, 1-day adult    4 carcass, 4-day adult    5 carcass, 20-day adult    5 ovary, virgin 4-day female    29 ovary, mated 4-day female    22 testis, mated 4-day male    12 accessory gland, mated 4-day male    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    22 central nervous system, larvae L3    21 central nervous system, pupae P8    19 head, virgin 1-day female    6 head, virgin 4-day female    7 head, virgin 20-day female    9 head, mated 1-day female    6 head, mated 4-day female    6 head, mated 20-day female    7 head, mated 1-day male    11 head, mated 4-day male    12 head, mated 20-day male    13 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    4 digestive system, larvae L3 wandering    8 digestive system, 1-day adult    6 digestive system, 4-day adult    7 digestive system, 20-day adult    7 fat body, larvae L3 wandering    2 fat body, white prepupae    6 fat body, pupae P8    12 carcass, larvae L3 wandering    14 carcass, 1-day adult    4 carcass, 4-day adult    5 carcass, 20-day adult    5 ovary, virgin 4-day female    29 ovary, mated 4-day female    22 testis, mated 4-day male    12 accessory gland, mated 4-day male    4 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    22 central nervous system, larvae L3    21 central nervous system, pupae P8    19 head, virgin 1-day female    6 head, virgin 4-day female    7 head, virgin 20-day female    9 head, mated 1-day female    6 head, mated 4-day female    6 head, mated 20-day female    7 head, mated 1-day male    11 head, mated 4-day male    12 head, mated 20-day male    13 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    4 digestive system, larvae L3 wandering    8 digestive system, 1-day adult    6 digestive system, 4-day adult    7 digestive system, 20-day adult    7 fat body, larvae L3 wandering    2 fat body, white prepupae    6 fat body, pupae P8    12 carcass, larvae L3 wandering    14 carcass, 1-day adult    4 carcass, 4-day adult    5 carcass, 20-day adult    5 ovary, virgin 4-day female    29 ovary, mated 4-day female    22 testis, mated 4-day male    12 accessory gland, mated 4-day male    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    22 central nervous system, larvae L3    21 central nervous system, pupae P8    19 head, virgin 1-day female    6 head, virgin 4-day female    7 head, virgin 20-day female    9 head, mated 1-day female    6 head, mated 4-day female    6 head, mated 20-day female    7 head, mated 1-day male    11 head, mated 4-day male    12 head, mated 20-day male    13 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    4 digestive system, larvae L3 wandering    8 digestive system, 1-day adult    6 digestive system, 4-day adult    7 digestive system, 20-day adult    7 fat body, larvae L3 wandering    2 fat body, white prepupae    6 fat body, pupae P8    12 carcass, larvae L3 wandering    14 carcass, 1-day adult    4 carcass, 4-day adult    5 carcass, 20-day adult    5 ovary, virgin 4-day female  29 ovary, mated 4-day female    22 testis, mated 4-day male    12 accessory gland, mated 4-day male    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    22 central nervous system, larvae L3    21 central nervous system, pupae P8    19 head, virgin 1-day female    6 head, virgin 4-day female    7 head, virgin 20-day female    9 head, mated 1-day female    6 head, mated 4-day female    6 head, mated 20-day female    7 head, mated 1-day male    11 head, mated 4-day male    12 head, mated 20-day male    13 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    4 digestive system, larvae L3 wandering    8 digestive system, 1-day adult    6 digestive system, 4-day adult    7 digestive system, 20-day adult    7 fat body, larvae L3 wandering    2 fat body, white prepupae    6 fat body, pupae P8    12 carcass, larvae L3 wandering    14 carcass, 1-day adult    4 carcass, 4-day adult    5 carcass, 20-day adult    5 ovary, virgin 4-day female    29 ovary, mated 4-day female    22 testis, mated 4-day male    12 accessory gland, mated 4-day male    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    22 central nervous system, larvae L3    21 central nervous system, pupae P8    19 head, virgin 1-day female    6 head, virgin 4-day female    7 head, virgin 20-day female    9 head, mated 1-day female    6 head, mated 4-day female    6 head, mated 20-day female    7 head, mated 1-day male    11 head, mated 4-day male    12 head, mated 20-day male    13 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    4 digestive system, larvae L3 wandering    8 digestive system, 1-day adult    6 digestive system, 4-day adult    7 digestive system, 20-day adult    7 fat body, larvae L3 wandering    2 fat body, white prepupae    6 fat body, pupae P8    12 carcass, larvae L3 wandering    14 carcass, 1-day adult    4 carcass, 4-day adult    5 carcass, 20-day adult    5 ovary, virgin 4-day female    29 ovary, mated 4-day female    22 testis, mated 4-day male    12 accessory gland, mated 4-day male    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression. Peak expression observed within 00-18 hour embryonic stages, during late larval stages, at stages throughout the pupal period, in stages of adults of both sexes. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    50 embryo 02-04hr    13 embryo 04-06hr    14 embryo 06-08hr    18 embryo 08-10hr    19 embryo 10-12hr    28 embryo 12-14hr    20 embryo 14-16hr    18 embryo 16-18hr    14 embryo 18-20hr    12 embryo 20-22hr    12 embryo 22-24hr    9 larva L1    15 larva L2    11 larva L3 12hr old    9 larva L3 puffstage 1-2    11 larva L3 puffstage 3-6    17 larva L3 puffstage 7-9    21 white prepupae new    20 white prepupae 12hr    24 white prepupae 24hr    26 pupae 2d postWPP    22 pupae 3d postWPP    14 pupae 4d postWPP    12 adult male 01day    16 adult male 05day    22 adult male 30day    20 adult female 01day    17 adult female 05day    26 adult female 30day    29 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (50) embryo 02-04hr    13 embryo 04-06hr    14 embryo 06-08hr    18 embryo 08-10hr    19 embryo 10-12hr  (28) embryo 12-14hr    20 embryo 14-16hr    18 embryo 16-18hr    14 embryo 18-20hr    12 embryo 20-22hr    12 embryo 22-24hr    9 larva L1    15 larva L2    11 larva L3 12hr old    9 larva L3 puffstage 1-2    11 larva L3 puffstage 3-6    17 larva L3 puffstage 7-9    21 white prepupae new    20 white prepupae 12hr    24 white prepupae 24hr  26 pupae 2d postWPP    22 pupae 3d postWPP    14 pupae 4d postWPP    12 adult male 01day    16 adult male 05day    22 adult male 30day    20 adult female 01day    17 adult female 05day  26 adult female 30day  (29) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    50 embryo 02-04hr    13 embryo 04-06hr    14 embryo 06-08hr    18 embryo 08-10hr    19 embryo 10-12hr    28 embryo 12-14hr    20 embryo 14-16hr    18 embryo 16-18hr    14 embryo 18-20hr    12 embryo 20-22hr    12 embryo 22-24hr    9 larva L1    15 larva L2    11 larva L3 12hr old    9 larva L3 puffstage 1-2    11 larva L3 puffstage 3-6    17 larva L3 puffstage 7-9    21 white prepupae new    20 white prepupae 12hr    24 white prepupae 24hr    26 pupae 2d postWPP    22 pupae 3d postWPP    14 pupae 4d postWPP    12 adult male 01day    16 adult male 05day    22 adult male 30day    20 adult female 01day    17 adult female 05day    26 adult female 30day    29 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    50 embryo 02-04hr    13 embryo 04-06hr    14 embryo 06-08hr    18 embryo 08-10hr    19 embryo 10-12hr    28 embryo 12-14hr    20 embryo 14-16hr    18 embryo 16-18hr    14 embryo 18-20hr    12 embryo 20-22hr    12 embryo 22-24hr    9 larva L1    15 larva L2    11 larva L3 12hr old    9 larva L3 puffstage 1-2    11 larva L3 puffstage 3-6    17 larva L3 puffstage 7-9    21 white prepupae new    20 white prepupae 12hr    24 white prepupae 24hr    26 pupae 2d postWPP    22 pupae 3d postWPP    14 pupae 4d postWPP    12 adult male 01day    16 adult male 05day    22 adult male 30day    20 adult female 01day    17 adult female 05day    26 adult female 30day    29 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    50 embryo 02-04hr    13 embryo 04-06hr    14 embryo 06-08hr    18 embryo 08-10hr    19 embryo 10-12hr    28 embryo 12-14hr    20 embryo 14-16hr    18 embryo 16-18hr    14 embryo 18-20hr    12 embryo 20-22hr    12 embryo 22-24hr    9 larva L1    15 larva L2    11 larva L3 12hr old    9 larva L3 puffstage 1-2    11 larva L3 puffstage 3-6    17 larva L3 puffstage 7-9    21 white prepupae new    20 white prepupae 12hr    24 white prepupae 24hr    26 pupae 2d postWPP    22 pupae 3d postWPP    14 pupae 4d postWPP    12 adult male 01day    16 adult male 05day    22 adult male 30day    20 adult female 01day    17 adult female 05day    26 adult female 30day    29 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (50) embryo 02-04hr    13 embryo 04-06hr    14 embryo 06-08hr    18 embryo 08-10hr    19 embryo 10-12hr  28 embryo 12-14hr    20 embryo 14-16hr    18 embryo 16-18hr    14 embryo 18-20hr    12 embryo 20-22hr    12 embryo 22-24hr    9 larva L1    15 larva L2    11 larva L3 12hr old    9 larva L3 puffstage 1-2    11 larva L3 puffstage 3-6    17 larva L3 puffstage 7-9    21 white prepupae new    20 white prepupae 12hr    24 white prepupae 24hr  26 pupae 2d postWPP    22 pupae 3d postWPP    14 pupae 4d postWPP    12 adult male 01day    16 adult male 05day    22 adult male 30day    20 adult female 01day    17 adult female 05day  26 adult female 30day  29 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    50 embryo 02-04hr    13 embryo 04-06hr    14 embryo 06-08hr    18 embryo 08-10hr    19 embryo 10-12hr    28 embryo 12-14hr    20 embryo 14-16hr    18 embryo 16-18hr    14 embryo 18-20hr    12 embryo 20-22hr    12 embryo 22-24hr    9 larva L1    15 larva L2    11 larva L3 12hr old    9 larva L3 puffstage 1-2    11 larva L3 puffstage 3-6    17 larva L3 puffstage 7-9    21 white prepupae new    20 white prepupae 12hr    24 white prepupae 24hr    26 pupae 2d postWPP    22 pupae 3d postWPP    14 pupae 4d postWPP    12 adult male 01day    16 adult male 05day    22 adult male 30day    20 adult female 01day    17 adult female 05day    26 adult female 30day    29 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    50 embryo 02-04hr    13 embryo 04-06hr    14 embryo 06-08hr    18 embryo 08-10hr    19 embryo 10-12hr    28 embryo 12-14hr    20 embryo 14-16hr    18 embryo 16-18hr    14 embryo 18-20hr    12 embryo 20-22hr    12 embryo 22-24hr    9 larva L1    15 larva L2    11 larva L3 12hr old    9 larva L3 puffstage 1-2    11 larva L3 puffstage 3-6    17 larva L3 puffstage 7-9    21 white prepupae new    20 white prepupae 12hr    24 white prepupae 24hr    26 pupae 2d postWPP    22 pupae 3d postWPP    14 pupae 4d postWPP    12 adult male 01day    16 adult male 05day    22 adult male 30day    20 adult female 01day    17 adult female 05day    26 adult female 30day    29 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    35 Schneider line 2 Sg4    30 embryonic 1182-4H    23 embryonic GM2    50 embryonic Kc167    32 embryonic S1    33 embryonic S3    21 leg disc CME L1    25 wing disc CME-W2    23 wing disc ML-DmD8    15 wing disc ML-DmD9    16 wing disc ML-DmD16-c3    15 wing disc ML-DmD21    19 wing disc ML-DmD32    17 haltere disc ML-DmD17-c3    15 eye-antennal disc ML-DmD11    16 antennal disc ML-DmD20-c5    27 mixed discs ML-DmD4-c1    19 CNS ML-DmBG1-c1    15 CNS ML-DmBG2-c2    71 tumorous blood cells mbn2    37 ovary fGS/OSS    9 ovary OSC    6 ovary OSS    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (35) Schneider line 2 Sg4  (30) embryonic 1182-4H    23 embryonic GM2  (50) embryonic Kc167  (32) embryonic S1  (33) embryonic S3    21 leg disc CME L1    25 wing disc CME-W2    23 wing disc ML-DmD8    15 wing disc ML-DmD9    16 wing disc ML-DmD16-c3    15 wing disc ML-DmD21    19 wing disc ML-DmD32    17 haltere disc ML-DmD17-c3    15 eye-antennal disc ML-DmD11    16 antennal disc ML-DmD20-c5  (27) mixed discs ML-DmD4-c1    19 CNS ML-DmBG1-c1    15 CNS ML-DmBG2-c2  (71) tumorous blood cells mbn2  (37) ovary fGS/OSS    9 ovary OSC    6 ovary OSS    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    35 Schneider line 2 Sg4    30 embryonic 1182-4H    23 embryonic GM2    50 embryonic Kc167    32 embryonic S1    33 embryonic S3    21 leg disc CME L1    25 wing disc CME-W2    23 wing disc ML-DmD8    15 wing disc ML-DmD9    16 wing disc ML-DmD16-c3    15 wing disc ML-DmD21    19 wing disc ML-DmD32    17 haltere disc ML-DmD17-c3    15 eye-antennal disc ML-DmD11    16 antennal disc ML-DmD20-c5    27 mixed discs ML-DmD4-c1    19 CNS ML-DmBG1-c1    15 CNS ML-DmBG2-c2    71 tumorous blood cells mbn2    37 ovary fGS/OSS    9 ovary OSC    6 ovary OSS    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    35 Schneider line 2 Sg4    30 embryonic 1182-4H    23 embryonic GM2    50 embryonic Kc167    32 embryonic S1    33 embryonic S3    21 leg disc CME L1    25 wing disc CME-W2    23 wing disc ML-DmD8    15 wing disc ML-DmD9    16 wing disc ML-DmD16-c3    15 wing disc ML-DmD21    19 wing disc ML-DmD32    17 haltere disc ML-DmD17-c3    15 eye-antennal disc ML-DmD11    16 antennal disc ML-DmD20-c5    27 mixed discs ML-DmD4-c1    19 CNS ML-DmBG1-c1    15 CNS ML-DmBG2-c2    71 tumorous blood cells mbn2    37 ovary fGS/OSS    9 ovary OSC    6 ovary OSS    2 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    35 Schneider line 2 Sg4    30 embryonic 1182-4H    23 embryonic GM2    50 embryonic Kc167    32 embryonic S1    33 embryonic S3    21 leg disc CME L1    25 wing disc CME-W2    23 wing disc ML-DmD8    15 wing disc ML-DmD9    16 wing disc ML-DmD16-c3    15 wing disc ML-DmD21    19 wing disc ML-DmD32    17 haltere disc ML-DmD17-c3    15 eye-antennal disc ML-DmD11    16 antennal disc ML-DmD20-c5    27 mixed discs ML-DmD4-c1    19 CNS ML-DmBG1-c1    15 CNS ML-DmBG2-c2    71 tumorous blood cells mbn2    37 ovary fGS/OSS    9 ovary OSC    6 ovary OSS    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (35) Schneider line 2 Sg4  30 embryonic 1182-4H    23 embryonic GM2  (50) embryonic Kc167  32 embryonic S1  (33) embryonic S3    21 leg disc CME L1    25 wing disc CME-W2    23 wing disc ML-DmD8    15 wing disc ML-DmD9    16 wing disc ML-DmD16-c3    15 wing disc ML-DmD21    19 wing disc ML-DmD32    17 haltere disc ML-DmD17-c3    15 eye-antennal disc ML-DmD11    16 antennal disc ML-DmD20-c5  27 mixed discs ML-DmD4-c1    19 CNS ML-DmBG1-c1    15 CNS ML-DmBG2-c2  (71) tumorous blood cells mbn2  (37) ovary fGS/OSS    9 ovary OSC    6 ovary OSS    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    35 Schneider line 2 Sg4    30 embryonic 1182-4H    23 embryonic GM2    50 embryonic Kc167    32 embryonic S1    33 embryonic S3    21 leg disc CME L1    25 wing disc CME-W2    23 wing disc ML-DmD8    15 wing disc ML-DmD9    16 wing disc ML-DmD16-c3    15 wing disc ML-DmD21    19 wing disc ML-DmD32    17 haltere disc ML-DmD17-c3    15 eye-antennal disc ML-DmD11    16 antennal disc ML-DmD20-c5    27 mixed discs ML-DmD4-c1    19 CNS ML-DmBG1-c1    15 CNS ML-DmBG2-c2    71 tumorous blood cells mbn2    37 ovary fGS/OSS    9 ovary OSC    6 ovary OSS    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    35 Schneider line 2 Sg4    30 embryonic 1182-4H    23 embryonic GM2    50 embryonic Kc167    32 embryonic S1    33 embryonic S3    21 leg disc CME L1    25 wing disc CME-W2    23 wing disc ML-DmD8    15 wing disc ML-DmD9    16 wing disc ML-DmD16-c3    15 wing disc ML-DmD21    19 wing disc ML-DmD32    17 haltere disc ML-DmD17-c3    15 eye-antennal disc ML-DmD11    16 antennal disc ML-DmD20-c5    27 mixed discs ML-DmD4-c1    19 CNS ML-DmBG1-c1    15 CNS ML-DmBG2-c2    71 tumorous blood cells mbn2    37 ovary fGS/OSS    9 ovary OSC    6 ovary OSS    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    8 cold shock, 4-day adult    7 heat shock, 4-day adult    12 Cadmium 50 mM 6 hrs, larvae L3    7 Cadmium 50 mM 12 hrs, larvae L3    9 Cadmium 50 mM 48 hrs, 4-day adult    12 Cadmium 100 mM 48 hrs, 4-day adult    15 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    10 Zinc 5 mM 12 hrs, larvae L3    8 Zinc 4.5 mM 48 hrs, 4-day adult    5 Ethanol 2.5% 3 hrs, larvae L3    22 Ethanol 5% 3 hrs, larvae L3    6 Ethanol 10% 3 hrs, larvae L3    6 Caffeine 1.5 mg/ml 4 hrs, larvae L3    5 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    17 Caffeine 25 mg/ml 48 hrs, 4-day adult    7 Paraquat 5 mM 48 hrs, 4-day adult    15 Paraquat 10 mM 48 hrs, 4-day adult    16 Rotenone 2 μg 12 hrs, larvae L3    7 Rotenone 8 μg 12 hrs, larvae L3    8 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    8 cold shock, 4-day adult    7 heat shock, 4-day adult    12 Cadmium 50 mM 6 hrs, larvae L3    7 Cadmium 50 mM 12 hrs, larvae L3    9 Cadmium 50 mM 48 hrs, 4-day adult    12 Cadmium 100 mM 48 hrs, 4-day adult    15 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    10 Zinc 5 mM 12 hrs, larvae L3    8 Zinc 4.5 mM 48 hrs, 4-day adult    5 Ethanol 2.5% 3 hrs, larvae L3    22 Ethanol 5% 3 hrs, larvae L3    6 Ethanol 10% 3 hrs, larvae L3    6 Caffeine 1.5 mg/ml 4 hrs, larvae L3    5 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    17 Caffeine 25 mg/ml 48 hrs, 4-day adult    7 Paraquat 5 mM 48 hrs, 4-day adult    15 Paraquat 10 mM 48 hrs, 4-day adult    16 Rotenone 2 μg 12 hrs, larvae L3    7 Rotenone 8 μg 12 hrs, larvae L3    8 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    8 cold shock, 4-day adult    7 heat shock, 4-day adult    12 Cadmium 50 mM 6 hrs, larvae L3    7 Cadmium 50 mM 12 hrs, larvae L3    9 Cadmium 50 mM 48 hrs, 4-day adult    12 Cadmium 100 mM 48 hrs, 4-day adult    15 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    10 Zinc 5 mM 12 hrs, larvae L3    8 Zinc 4.5 mM 48 hrs, 4-day adult    5 Ethanol 2.5% 3 hrs, larvae L3    22 Ethanol 5% 3 hrs, larvae L3    6 Ethanol 10% 3 hrs, larvae L3    6 Caffeine 1.5 mg/ml 4 hrs, larvae L3    5 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    17 Caffeine 25 mg/ml 48 hrs, 4-day adult    7 Paraquat 5 mM 48 hrs, 4-day adult    15 Paraquat 10 mM 48 hrs, 4-day adult    16 Rotenone 2 μg 12 hrs, larvae L3    7 Rotenone 8 μg 12 hrs, larvae L3    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    8 cold shock, 4-day adult    7 heat shock, 4-day adult    12 Cadmium 50 mM 6 hrs, larvae L3    7 Cadmium 50 mM 12 hrs, larvae L3    9 Cadmium 50 mM 48 hrs, 4-day adult    12 Cadmium 100 mM 48 hrs, 4-day adult    15 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    10 Zinc 5 mM 12 hrs, larvae L3    8 Zinc 4.5 mM 48 hrs, 4-day adult    5 Ethanol 2.5% 3 hrs, larvae L3    22 Ethanol 5% 3 hrs, larvae L3    6 Ethanol 10% 3 hrs, larvae L3    6 Caffeine 1.5 mg/ml 4 hrs, larvae L3    5 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    17 Caffeine 25 mg/ml 48 hrs, 4-day adult    7 Paraquat 5 mM 48 hrs, 4-day adult    15 Paraquat 10 mM 48 hrs, 4-day adult    16 Rotenone 2 μg 12 hrs, larvae L3    7 Rotenone 8 μg 12 hrs, larvae L3    8 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    8 cold shock, 4-day adult    7 heat shock, 4-day adult    12 Cadmium 50 mM 6 hrs, larvae L3    7 Cadmium 50 mM 12 hrs, larvae L3    9 Cadmium 50 mM 48 hrs, 4-day adult    12 Cadmium 100 mM 48 hrs, 4-day adult    15 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    10 Zinc 5 mM 12 hrs, larvae L3    8 Zinc 4.5 mM 48 hrs, 4-day adult    5 Ethanol 2.5% 3 hrs, larvae L3    22 Ethanol 5% 3 hrs, larvae L3    6 Ethanol 10% 3 hrs, larvae L3    6 Caffeine 1.5 mg/ml 4 hrs, larvae L3    5 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    17 Caffeine 25 mg/ml 48 hrs, 4-day adult    7 Paraquat 5 mM 48 hrs, 4-day adult    15 Paraquat 10 mM 48 hrs, 4-day adult    16 Rotenone 2 μg 12 hrs, larvae L3    7 Rotenone 8 μg 12 hrs, larvae L3    8 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    8 cold shock, 4-day adult    7 heat shock, 4-day adult    12 Cadmium 50 mM 6 hrs, larvae L3    7 Cadmium 50 mM 12 hrs, larvae L3    9 Cadmium 50 mM 48 hrs, 4-day adult    12 Cadmium 100 mM 48 hrs, 4-day adult    15 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    10 Zinc 5 mM 12 hrs, larvae L3    8 Zinc 4.5 mM 48 hrs, 4-day adult    5 Ethanol 2.5% 3 hrs, larvae L3    22 Ethanol 5% 3 hrs, larvae L3    6 Ethanol 10% 3 hrs, larvae L3    6 Caffeine 1.5 mg/ml 4 hrs, larvae L3    5 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    17 Caffeine 25 mg/ml 48 hrs, 4-day adult    7 Paraquat 5 mM 48 hrs, 4-day adult    15 Paraquat 10 mM 48 hrs, 4-day adult    16 Rotenone 2 μg 12 hrs, larvae L3    7 Rotenone 8 μg 12 hrs, larvae L3    8 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    8 cold shock, 4-day adult    7 heat shock, 4-day adult    12 Cadmium 50 mM 6 hrs, larvae L3    7 Cadmium 50 mM 12 hrs, larvae L3    9 Cadmium 50 mM 48 hrs, 4-day adult    12 Cadmium 100 mM 48 hrs, 4-day adult    15 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    10 Zinc 5 mM 12 hrs, larvae L3    8 Zinc 4.5 mM 48 hrs, 4-day adult    5 Ethanol 2.5% 3 hrs, larvae L3    22 Ethanol 5% 3 hrs, larvae L3    6 Ethanol 10% 3 hrs, larvae L3    6 Caffeine 1.5 mg/ml 4 hrs, larvae L3    5 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    17 Caffeine 25 mg/ml 48 hrs, 4-day adult    7 Paraquat 5 mM 48 hrs, 4-day adult    15 Paraquat 10 mM 48 hrs, 4-day adult    16 Rotenone 2 μg 12 hrs, larvae L3    7 Rotenone 8 μg 12 hrs, larvae L3    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    8 cold shock, 4-day adult    7 heat shock, 4-day adult    12 Cadmium 50 mM 6 hrs, larvae L3    7 Cadmium 50 mM 12 hrs, larvae L3    9 Cadmium 50 mM 48 hrs, 4-day adult    12 Cadmium 100 mM 48 hrs, 4-day adult    15 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    10 Zinc 5 mM 12 hrs, larvae L3    8 Zinc 4.5 mM 48 hrs, 4-day adult    5 Ethanol 2.5% 3 hrs, larvae L3    22 Ethanol 5% 3 hrs, larvae L3    6 Ethanol 10% 3 hrs, larvae L3    6 Caffeine 1.5 mg/ml 4 hrs, larvae L3    5 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    17 Caffeine 25 mg/ml 48 hrs, 4-day adult    7 Paraquat 5 mM 48 hrs, 4-day adult    15 Paraquat 10 mM 48 hrs, 4-day adult    16 Rotenone 2 μg 12 hrs, larvae L3    7 Rotenone 8 μg 12 hrs, larvae L3    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_06 mE1_20_mRNA_expression_cluster_09
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0037884 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG17184-RB
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable Arfipd04253 ArfipEY11874 viable, with Scer\GAL4pnr-MD237 ArfipGD9307 Sterility Allele fertile Arfipd04253 ArfipEY11874 Other Phenotypes Allele chemical sensitive (with Arfip12) Arfip71 chemical sensitive (with Arfip71) Arfip12 chemical sensitive | recessive Arfip12 neuroanatomy defective | pharate adult stage, with Scer\GAL4Ccap.PP Arfipd04253 Phenotype manifest in Allele neurite | pharate adult stage, with Scer\GAL4Ccap.PP Arfipd04253
Classical Alleles ( 6 )
For All Classical Alleles Show
Allele of Arfip Class Mutagen Stocks Known lesion Arfipd04253 P-element activity 2 Yes Arfipd04252 P-element activity 1 -- ArfipEY11874 P-element activity 1 Yes ArfipUM-8176-3 1 Yes Arfip12 amorphic allele - molecular evidence P-element activity 0 Yes Arfip71 amorphic allele - molecular evidence 0 --
Alleles Carried on Transgenic Constructs ( 3 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Arfip Class Mutagen Stocks Known lesion ArfipGD9307 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes ArfipKK102955 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes ArfipScer\UAS.T:Ivir\HA1 in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{UAS-Arfip.HA} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EPgy2}ArfipEY11874 NA P{XP}Arfipd04252 NA P{XP}Arfipd04253 NA miscellaneous insertions P{RS3}ArfipUM-8176-3 NA
Gene Ontology: Function, Process & Cellular Component ( 2 unique terms )
Terms Based on Experimental Evidence ( 1 term )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
behavioral response to ethanol inferred from mutant phenotype (Peru Y Colón de Portugal et al., 2012)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 1 term )
Molecular Function
CV term Evidence References
protein domain specific binding inferred from electronic annotation with InterPro:IPR010504 (FlyBase Curators et al., 2004-)
Biological Process ( 0 terms)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
Arfip - RnrS anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Arfip allele Gene References
External Data
Linkouts	DroID - A comprehensive database of gene and protein interactions. • FBgn0037884 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 41353
Orthologs
OrthoDB Orthologs (45) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG602XC7 Dipteran inclusive ortholog search EOG6KPTKM Insect inclusive ortholog search EOG6FTTW7 Arthropod inclusive ortholog search EOG6X95ZT Metazoa inclusive ortholog search EOG6C8MMB
Orthologs in Drosophila Species (EOG602XC7)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\Arfip     Drosophila simulans   Dsim\GD18741 Y   Drosophila sechellia   Dsec\GM26111 Y   Drosophila erecta   Dere\GG17231 Y   Drosophila yakuba   Dyak\GE24633 Y   Drosophila ananassae   Dana\GF18250 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA14372 Y   Drosophila persimilis   Dper\GL12025 Y   Drosophila willistoni   Dwil\GK11946 Y   Drosophila virilis   Dvir\GJ23979 Y   Drosophila mojavensis   Dmoj\GI23886 Y   Drosophila grimshawi   Dgri\GH17348 Y
Orthologs in non-Drosophila Dipterans (EOG6KPTKM)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Anopheles gambiae Malaria mosquito  Agam\AGAP004910
Orthologs in non-Dipteran Insects (EOG6FTTW7)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\LOC412599   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG014075   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH23546   Atta cephalotes Leafcutter ant  Acep\ACEP21897   Camponotus floridanus Florida carpenter ant  Cflo\CFLO18409   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL20621   Linepithema humile Argentine ant  Lhum\LH12864   Pogonomyrmex barbatus Red harvester ant  Pbar\PB16565   Solenopsis invicta Red fire ant  Sinv\SINV17218   Solenopsis invicta Red fire ant  Sinv\SINV17220   Acyrthosiphon pisum Pea aphid  Apim\ACYPI000821   Bombyx mori Silkmoth  Bmor\BGIBMGA009991   Pediculus humanus Human body louse  Phum\PHUM357560   Tribolium castaneum Red flour beetle  Tcas\TC001620
Orthologs in non-Insect Arthropods (EOG6X95ZT)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\COII   Ixodes scapularis Deer tick  Isca\ISCW022668
Orthologs in non-Arthropod Metazoa (EOG6C8MMB)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\F54C8.7   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_024178gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_011861gn   Danio rerio Zebrafish  Drer\arfip2b   Danio rerio Zebrafish  Drer\arfip2a   Danio rerio Zebrafish  Drer\arfip1   Xenopus tropicalis Western clawed frog  Xtro\arfip2   Xenopus tropicalis Western clawed frog  Xtro\arfip1   Gallus gallus Domestic chicken  Ggal\ARFIP1   Gallus gallus Domestic chicken  Ggal\ARFIP2   Mus musculus House mouse  Mmus\Arfip1   Mus musculus House mouse  Mmus\Arfip2   Rattus norvegicus Norway rat  Rnor\Arfip1   Rattus norvegicus Norway rat  Rnor\Arfip2   Homo sapiens Human  Hsap\ARFIP2   Homo sapiens Human  Hsap\ARFIP1
Human Orthologs (2)
Gene OMIM HGNC Hsap\ARFIP2     Hsap\ARFIP1
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD18741 Drosophila sechellia Dsec\GM26111 Drosophila erecta Dere\GG17231 Drosophila yakuba Dyak\GE24633 Drosophila ananassae Dana\GF18250 Drosophila pseudoobscura pseudoobscura Dpse\GA14372 Drosophila persimilis Dper\GL12025 Drosophila willistoni Dwil\GK11946 Drosophila virilis Dvir\GJ23979 Drosophila mojavensis Dmoj\GI23886 Drosophila grimshawi Dgri\GH17348
Stocks & Reagents
Stocks Listed in FlyBase ( 7 )
Bloomington	19201 w1118; P{XP}Arfipd04253 20706 y1 w67c23; P{EPgy2}ArfipEY11874
Harvard	- P{XP}Arfipd04252 - P{XP}Arfipd04253
Kyoto	124395 w1118; P{RS3}ArfipUM-8176-3
VDRC	v103951 P{KK102955}VIE-260B v20401 w1118; P{GD9307}v20401
Genomic Clones ( 2 )
	BACR48B07 BACR48M21 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 23 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	IP10803 LD44124
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH07838 LD34664 LD46473 RE03175 RE18291 RE20943 RE42769 RE57807 RE64891 RE66152 RE69202 RE70787 RE74359 SD14920 SD19973
Other clones	117516 281140 Dmel_neb_006290_0693_2134 EC34327 EK236547 EK306149
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0037884 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 41353
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: Arfip CG17184 (Peru Y Colón de Portugal et al., 2012)
Source for database merge of
Additional comments
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_141801 RefSeq (Proteins) • NP_650058 DDBJ / EMBL / GenBank • AAF54618 AAN13497 AAO45223 AI512315 AW943697 BT004867 CL868525 CZ473812 CZ473813 Entrez Gene - A searchable database of RefSeq genes. • 41353 UniProtKB/TrEMBL • Q9VGQ8
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Arfaptin homology (AH) domain (IPR010504) Arfaptin homology (AH) domain/BAR domain (IPR027267)
Linkouts
	DroID - A comprehensive database of gene and protein interactions. • FBgn0037884 DRSC - Results from RNAi screens. • FBgn0037884 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0037884 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG17184-RB FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0037884 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 41353 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 41353 modMine - Data generated by the modENCODE project. • FBgn0037884
Synonyms & Secondary IDs ( 5 )
Reported As
Symbol Synonym	Arfip (Peru Y Colón de Portugal et al., 2012) CG17184 (Peru Y Colón de Portugal et al., 2012, Korolchuk et al., 2007, Keleman et al., 2009.8.5, Cheli et al., 2010)
Name Synonym	Arfaptin (Peru Y Colón de Portugal et al., 2012, ) arfaptin-2 (Korolchuk et al., 2007) partner of Rac1 (Korolchuk et al., 2007)
Secondary FlyBase IDs
References ( 19 )
Research paper	Peru Y Colón de Portugal et al., 2012, J. Neurosci. 32(49): 17706--17713 Adult Neuronal Arf6 Controls Ethanol-Induced Behavior with Arfaptin Downstream of Rac1 and RhoGAP18B. [FBrf0220158] Spasic et al., 2012, PLoS Genet. 8(1): e1002433 Genome-Wide Assessment of AU-Rich Elements by the AREScore Algorithm. [FBrf0217189] Cheli et al., 2010, Hum. Mol. Genet. 19(5): 861--878 Genetic modifiers of abnormal organelle biogenesis in a Drosophila model of BLOC-1 deficiency. [FBrf0209903] Zhao et al., 2008, Genetics 178(2): 883--901 A Drosophila gain-of-function screen for candidate genes involved in steroid-dependent neuroendocrine cell remodeling. [FBrf0204350] Korolchuk et al., 2007, J. Cell Sci. 120(24): 4367--4376 Drosophila Vps35 function is necessary for normal endocytic trafficking and actin cytoskeleton organisation. [FBrf0202367] Borras et al., 2003, Genetics 163(2): 637--645 Transcription profiling in Drosophila eyes that overexpress the human glaucoma-associated trabecular meshwork-inducible glucocorticoid response protein/myocilin (TIGR/MYOC). [FBrf0157243]
Supplementary material	Graveley et al., 2011, Nature 471(7339): Supplementary Table 33. Fuzzy Cluster Members. [FBrf0213980] The modENCODE Consortium, 2010, Science 330(6012): DataS14: Gene co-expression clusters. [FBrf0213979] Mummery-Widmer et al., 2009, Nature 458(7241): Supplementary Table 2 - Genome-wide bristle screen results. [FBrf0214518]
Personal communication to FlyBase	Keleman et al., 2009.8.5, RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0208510] Mintseris et al., 2009.11.23, DPiM: the Drosophila Protein Interaction Mapping project DPiM: the Drosophila Protein Interaction Mapping project [FBrf0209452] Dickson et al., 2007.7.18, RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0200327] Gene Disruption Project members and Exelixis, 2005, Genomic mapping of Exelixis insertion collection. (Computer file) Genomic mapping of Exelixis insertion collection. (Computer file) [FBrf0184340] Bloomington Drosophila Stock Center, 2004.11.6, Exelixis insertion alleles that are not in FlyBase. Exelixis insertion alleles that are not in FlyBase. [FBrf0179797] FlyBase Curators et al., 2004-, Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. [FBrf0174215] Gene Disruption Project members, 2001-, (Computer file) (Computer file) [FBrf0132177] BDGP Project Members, 2000-, Berkeley Drosophila Genome Project. (Computer file) Berkeley Drosophila Genome Project. (Computer file) [FBrf0125078]
FlyBase analysis	FlyBase, 1992-, FlyBase curation. FlyBase curation. [FBrf0105495]
Curated genome annotation	FamiliarityBreedsContempt, 1999.11, [Automatic annotations performed at the Celera Jamboreee.] [Automatic annotations performed at the Celera Jamboreee.] [FBrf0126705]