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Gene Dmel\CG6719

General Information
Symbol	Dmel\CG6719	Species	D. melanogaster
Name		Annotation symbol	CG6719
Feature type	protein_coding_gene	FlyBase ID	FBgn0037893
Gene Model Status	Current	Stock availability	4 publicly available
Genomic Location
Chromosome (arm)	3R	Recombination map
Cytogenetic map	86E4-86E4	Sequence location	3R:7,234,514..7,235,609 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	This gene is referred to in FlyBase by the symbol Dmel\CG6719 (FBgn0037893). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: chaperone binding. Based on sequence similarity, it is predicted to be involved in the biological process: 'de novo' protein folding. 3 alleles are reported. The phenotype of these alleles is annotated with: trichogen cell. It has one annotated transcript and one annotated polypeptide. Protein features are: Prefoldin; Prefoldin subunit; Prefoldin, subunit 3. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderately high expression. Peak expression observed within 00-12 hour embryonic stages, during early larval stages, in adult female stages. Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: larval central nervous system, larval trachea, adult ovary. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, adult spermathecae, adult male reproductive system, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1639895_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of CG6719. Gene sequence location is 3R:7234514..7235609.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2012_01	Sequence features BKN21935 HFA16099
FB2011_10
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 86E4-86E4   Limits computationally determined from genome sequence between P{EP}EP3340EP3340 and P{PZ}tho1&P{PZ}l(3)0462905275
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\CG6719 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) CG6719-RA FBtr0082406  NM_141810   958   194
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein CG6719-PA   FBpp0081882   22.3   194   4.76     NP_650067   AAF54630
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Prefoldin subunit (IPR004127) Prefoldin (IPR009053) Prefoldin, subunit 3 (IPR016655)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA694930   AA696515   AA801880   AA802522   AA990895   AE014297 AAF54630   AW943231   BI355256   BI564089   BI566650   BI576153   BI577722   BI585110   BI618849   BI630492   BI634150   BP542831   BP542832   BP549029   BP549030   BP556745   BP556746   BP559151   BP559152   BT003247 AAO25004   CO185215   CO314453   EC058066   EC202893   EC247565   EV592950   GH747963   GH750966   GH751856   GH751962   GH752108   GH757103   GH758956   GH759524   GH761408   GH770557   GH771295   GH772864   GH774197   GH774559   GH778640   GH779145   GH785234   GH786414   GH787660   GH789215   GH791492   GH791725   GH793663   GH799494   GH802734   GH803521   GH804046   GH804279   GH806503   GH814240   GH815630   GH815809   GH822538   GH825289   GH833628   GH834379   GH835111   GH835221   GH835418   GH835446   GH836139   GH841996   GH843220   GH843686   GH843745   GH845469   GH846798   GH852286   GH858097   GH863364   GH871885   GH875552   GH877847   GH883803   GH887489   GH893260   GH895008   GH898052   GH900679   GH901297   GH904901   GH907037   GH907740   GH909115   GH909724   GH910373   GH910763   GH911473   GH916453   GH917269   GH922476   GH927510   GH932221   GH933489   GH936741   GH936805   GH937176   GH939146
UniProtKB/Swiss-Prot	Q9VGP6
UniProtKB/TrEMBL	Q86PA8
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0037893    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0037893 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderately high expression. Peak expression observed within 00-12 hour embryonic stages, during early larval stages, in adult female stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0037893 expression level Developmental Stage   Expression Level embryo 00-02hr    6669 embryo 02-04hr    1496 embryo 04-06hr    3042 embryo 06-08hr    3387 embryo 08-10hr    3469 embryo 10-12hr    5189 embryo 12-14hr    3819 embryo 14-16hr    3682 embryo 16-18hr    3404 embryo 18-20hr    2637 embryo 20-22hr    2111 embryo 22-24hr    2100 larva L1    4582 larva L2    4839 larva L3 12hr old    4271 larva L3 puffstage 1-2    2879 larva L3 puffstage 3-6    2913 larva L3 puffstage 7-9    3554 white prepupae new    3339 white prepupae 12hr    3127 white prepupae 24hr    3956 pupae 2d postWPP    3858 pupae 3d postWPP    3271 pupae 4d postWPP    1486 adult male 01day    1711 adult male 05day    2124 adult male 30day    2099 adult female 01day    3484 adult female 05day    6459 adult female 30day    6872 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (6669) embryo 02-04hr  (1496) embryo 04-06hr  (3042) embryo 06-08hr  (3387) embryo 08-10hr  (3469) embryo 10-12hr  (5189) embryo 12-14hr  (3819) embryo 14-16hr  (3682) embryo 16-18hr  (3404) embryo 18-20hr  (2637) embryo 20-22hr  (2111) embryo 22-24hr  (2100) larva L1  (4582) larva L2  (4839) larva L3 12hr old  (4271) larva L3 puffstage 1-2  (2879) larva L3 puffstage 3-6  (2913) larva L3 puffstage 7-9  (3554) white prepupae new  (3339) white prepupae 12hr  (3127) white prepupae 24hr  (3956) pupae 2d postWPP  (3858) pupae 3d postWPP  (3271) pupae 4d postWPP  (1486) adult male 01day  (1711) adult male 05day  (2124) adult male 30day  (2099) adult female 01day  (3484) adult female 05day  (6459) adult female 30day  (6872) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (6669) embryo 02-04hr  1496 embryo 04-06hr  (3042) embryo 06-08hr  (3387) embryo 08-10hr  (3469) embryo 10-12hr  (5189) embryo 12-14hr  (3819) embryo 14-16hr  (3682) embryo 16-18hr  (3404) embryo 18-20hr  (2637) embryo 20-22hr  (2111) embryo 22-24hr  (2100) larva L1  (4582) larva L2  (4839) larva L3 12hr old  (4271) larva L3 puffstage 1-2  (2879) larva L3 puffstage 3-6  (2913) larva L3 puffstage 7-9  (3554) white prepupae new  (3339) white prepupae 12hr  (3127) white prepupae 24hr  (3956) pupae 2d postWPP  (3858) pupae 3d postWPP  (3271) pupae 4d postWPP  1486 adult male 01day  (1711) adult male 05day  (2124) adult male 30day  (2099) adult female 01day  (3484) adult female 05day  (6459) adult female 30day  (6872) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    6669 embryo 02-04hr    1496 embryo 04-06hr    3042 embryo 06-08hr    3387 embryo 08-10hr    3469 embryo 10-12hr    5189 embryo 12-14hr    3819 embryo 14-16hr    3682 embryo 16-18hr    3404 embryo 18-20hr    2637 embryo 20-22hr    2111 embryo 22-24hr    2100 larva L1    4582 larva L2    4839 larva L3 12hr old    4271 larva L3 puffstage 1-2    2879 larva L3 puffstage 3-6    2913 larva L3 puffstage 7-9    3554 white prepupae new    3339 white prepupae 12hr    3127 white prepupae 24hr    3956 pupae 2d postWPP    3858 pupae 3d postWPP    3271 pupae 4d postWPP    1486 adult male 01day    1711 adult male 05day    2124 adult male 30day    2099 adult female 01day    3484 adult female 05day    6459 adult female 30day    6872 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    6669 embryo 02-04hr    1496 embryo 04-06hr    3042 embryo 06-08hr    3387 embryo 08-10hr    3469 embryo 10-12hr    5189 embryo 12-14hr    3819 embryo 14-16hr    3682 embryo 16-18hr    3404 embryo 18-20hr    2637 embryo 20-22hr    2111 embryo 22-24hr    2100 larva L1    4582 larva L2    4839 larva L3 12hr old    4271 larva L3 puffstage 1-2    2879 larva L3 puffstage 3-6    2913 larva L3 puffstage 7-9    3554 white prepupae new    3339 white prepupae 12hr    3127 white prepupae 24hr    3956 pupae 2d postWPP    3858 pupae 3d postWPP    3271 pupae 4d postWPP    1486 adult male 01day    1711 adult male 05day    2124 adult male 30day    2099 adult female 01day    3484 adult female 05day    6459 adult female 30day    6872 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0037893 expression level Developmental Stage   Expression Level embryo 00-02hr    6669 embryo 02-04hr    1496 embryo 04-06hr    3042 embryo 06-08hr    3387 embryo 08-10hr    3469 embryo 10-12hr    5189 embryo 12-14hr    3819 embryo 14-16hr    3682 embryo 16-18hr    3404 embryo 18-20hr    2637 embryo 20-22hr    2111 embryo 22-24hr    2100 larva L1    4582 larva L2    4839 larva L3 12hr old    4271 larva L3 puffstage 1-2    2879 larva L3 puffstage 3-6    2913 larva L3 puffstage 7-9    3554 white prepupae new    3339 white prepupae 12hr    3127 white prepupae 24hr    3956 pupae 2d postWPP    3858 pupae 3d postWPP    3271 pupae 4d postWPP    1486 adult male 01day    1711 adult male 05day    2124 adult male 30day    2099 adult female 01day    3484 adult female 05day    6459 adult female 30day    6872 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (6669) embryo 02-04hr  (1496) embryo 04-06hr  (3042) embryo 06-08hr  (3387) embryo 08-10hr  (3469) embryo 10-12hr  (5189) embryo 12-14hr  (3819) embryo 14-16hr  (3682) embryo 16-18hr  (3404) embryo 18-20hr  (2637) embryo 20-22hr  (2111) embryo 22-24hr  (2100) larva L1  (4582) larva L2  (4839) larva L3 12hr old  (4271) larva L3 puffstage 1-2  (2879) larva L3 puffstage 3-6  (2913) larva L3 puffstage 7-9  (3554) white prepupae new  (3339) white prepupae 12hr  (3127) white prepupae 24hr  (3956) pupae 2d postWPP  (3858) pupae 3d postWPP  (3271) pupae 4d postWPP  (1486) adult male 01day  (1711) adult male 05day  (2124) adult male 30day  (2099) adult female 01day  (3484) adult female 05day  (6459) adult female 30day  (6872) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (6669) embryo 02-04hr  1496 embryo 04-06hr  (3042) embryo 06-08hr  (3387) embryo 08-10hr  (3469) embryo 10-12hr  (5189) embryo 12-14hr  (3819) embryo 14-16hr  (3682) embryo 16-18hr  (3404) embryo 18-20hr  (2637) embryo 20-22hr  2111 embryo 22-24hr  2100 larva L1  (4582) larva L2  (4839) larva L3 12hr old  (4271) larva L3 puffstage 1-2  (2879) larva L3 puffstage 3-6  (2913) larva L3 puffstage 7-9  (3554) white prepupae new  (3339) white prepupae 12hr  (3127) white prepupae 24hr  (3956) pupae 2d postWPP  (3858) pupae 3d postWPP  (3271) pupae 4d postWPP  1486 adult male 01day  1711 adult male 05day  2124 adult male 30day  2099 adult female 01day  (3484) adult female 05day  (6459) adult female 30day  (6872) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    6669 embryo 02-04hr    1496 embryo 04-06hr    3042 embryo 06-08hr    3387 embryo 08-10hr    3469 embryo 10-12hr    5189 embryo 12-14hr    3819 embryo 14-16hr    3682 embryo 16-18hr    3404 embryo 18-20hr    2637 embryo 20-22hr    2111 embryo 22-24hr    2100 larva L1    4582 larva L2    4839 larva L3 12hr old    4271 larva L3 puffstage 1-2    2879 larva L3 puffstage 3-6    2913 larva L3 puffstage 7-9    3554 white prepupae new    3339 white prepupae 12hr    3127 white prepupae 24hr    3956 pupae 2d postWPP    3858 pupae 3d postWPP    3271 pupae 4d postWPP    1486 adult male 01day    1711 adult male 05day    2124 adult male 30day    2099 adult female 01day    3484 adult female 05day    6459 adult female 30day    6872 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    6669 embryo 02-04hr    1496 embryo 04-06hr    3042 embryo 06-08hr    3387 embryo 08-10hr    3469 embryo 10-12hr    5189 embryo 12-14hr    3819 embryo 14-16hr    3682 embryo 16-18hr    3404 embryo 18-20hr    2637 embryo 20-22hr    2111 embryo 22-24hr    2100 larva L1    4582 larva L2    4839 larva L3 12hr old    4271 larva L3 puffstage 1-2    2879 larva L3 puffstage 3-6    2913 larva L3 puffstage 7-9    3554 white prepupae new    3339 white prepupae 12hr    3127 white prepupae 24hr    3956 pupae 2d postWPP    3858 pupae 3d postWPP    3271 pupae 4d postWPP    1486 adult male 01day    1711 adult male 05day    2124 adult male 30day    2099 adult female 01day    3484 adult female 05day    6459 adult female 30day    6872 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0037893    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0037893 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: larval central nervous system, larval trachea, adult ovary. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, adult spermathecae, adult male reproductive system, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0037893 expression level Tissue   Expression Level Larval Central Nervous System    629.575 Larval Midgut    289.8 Larval Hindgut    431.6 Larval Malpighian Tubules    277.1 Larval Fat Body    275.5 Larval Salivary Gland    438.6 Larval Trachea    607.6 Larval Carcass    418.95 Adult Head    242.2 Adult Eye    239.975 Adult Brain    302.4 Adult Thoracic-Abdominal Ganglion    317.8 Adult Crop    387 Adult Midgut    328.5 Adult Hindgut    395.8 Adult Malpighian Tubules    197.2 Adult Fat Body    219.9 Adult Salivary Gland    303 Adult Heart    219.225 Adult VirginFemale Spermatheca    147.4 Adult InseminatedFemale Spermatheca    190.7 Adult Ovary    730.6 Adult Testis    280.3 Adult Male Accessory Gland    412.5 Adult Carcass    188.6 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (629.575) Larval Midgut    289.8 Larval Hindgut    431.6 Larval Malpighian Tubules    277.1 Larval Fat Body    275.5 Larval Salivary Gland    438.6 Larval Trachea  (607.6) Larval Carcass    418.95 Adult Head    242.2 Adult Eye    239.975 Adult Brain    302.4 Adult Thoracic-Abdominal Ganglion    317.8 Adult Crop    387 Adult Midgut    328.5 Adult Hindgut    395.8 Adult Malpighian Tubules    197.2 Adult Fat Body    219.9 Adult Salivary Gland    303 Adult Heart    219.225 Adult VirginFemale Spermatheca    147.4 Adult InseminatedFemale Spermatheca    190.7 Adult Ovary  (730.6) Adult Testis    280.3 Adult Male Accessory Gland    412.5 Adult Carcass    188.6 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    629.575 Larval Midgut    289.8 Larval Hindgut    431.6 Larval Malpighian Tubules    277.1 Larval Fat Body    275.5 Larval Salivary Gland    438.6 Larval Trachea    607.6 Larval Carcass    418.95 Adult Head    242.2 Adult Eye    239.975 Adult Brain    302.4 Adult Thoracic-Abdominal Ganglion    317.8 Adult Crop    387 Adult Midgut    328.5 Adult Hindgut    395.8 Adult Malpighian Tubules    197.2 Adult Fat Body    219.9 Adult Salivary Gland    303 Adult Heart    219.225 Adult VirginFemale Spermatheca    147.4 Adult InseminatedFemale Spermatheca    190.7 Adult Ovary    730.6 Adult Testis    280.3 Adult Male Accessory Gland    412.5 Adult Carcass    188.6 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    629.575 Larval Midgut    289.8 Larval Hindgut    431.6 Larval Malpighian Tubules    277.1 Larval Fat Body    275.5 Larval Salivary Gland    438.6 Larval Trachea    607.6 Larval Carcass    418.95 Adult Head    242.2 Adult Eye    239.975 Adult Brain    302.4 Adult Thoracic-Abdominal Ganglion    317.8 Adult Crop    387 Adult Midgut    328.5 Adult Hindgut    395.8 Adult Malpighian Tubules    197.2 Adult Fat Body    219.9 Adult Salivary Gland    303 Adult Heart    219.225 Adult VirginFemale Spermatheca    147.4 Adult InseminatedFemale Spermatheca    190.7 Adult Ovary    730.6 Adult Testis    280.3 Adult Male Accessory Gland    412.5 Adult Carcass    188.6 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0037893 expression level Tissue   Expression Level Larval Central Nervous System    629.575 Larval Midgut    289.8 Larval Hindgut    431.6 Larval Malpighian Tubules    277.1 Larval Fat Body    275.5 Larval Salivary Gland    438.6 Larval Trachea    607.6 Larval Carcass    418.95 Adult Head    242.2 Adult Eye    239.975 Adult Brain    302.4 Adult Thoracic-Abdominal Ganglion    317.8 Adult Crop    387 Adult Midgut    328.5 Adult Hindgut    395.8 Adult Malpighian Tubules    197.2 Adult Fat Body    219.9 Adult Salivary Gland    303 Adult Heart    219.225 Adult VirginFemale Spermatheca    147.4 Adult InseminatedFemale Spermatheca    190.7 Adult Ovary    730.6 Adult Testis    280.3 Adult Male Accessory Gland    412.5 Adult Carcass    188.6 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  629.575 Larval Midgut    289.8 Larval Hindgut    431.6 Larval Malpighian Tubules    277.1 Larval Fat Body    275.5 Larval Salivary Gland    438.6 Larval Trachea  607.6 Larval Carcass    418.95 Adult Head    242.2 Adult Eye    239.975 Adult Brain    302.4 Adult Thoracic-Abdominal Ganglion    317.8 Adult Crop    387 Adult Midgut    328.5 Adult Hindgut    395.8 Adult Malpighian Tubules    197.2 Adult Fat Body    219.9 Adult Salivary Gland    303 Adult Heart    219.225 Adult VirginFemale Spermatheca    147.4 Adult InseminatedFemale Spermatheca    190.7 Adult Ovary  730.6 Adult Testis    280.3 Adult Male Accessory Gland    412.5 Adult Carcass    188.6 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    629.575 Larval Midgut    289.8 Larval Hindgut    431.6 Larval Malpighian Tubules    277.1 Larval Fat Body    275.5 Larval Salivary Gland    438.6 Larval Trachea    607.6 Larval Carcass    418.95 Adult Head    242.2 Adult Eye    239.975 Adult Brain    302.4 Adult Thoracic-Abdominal Ganglion    317.8 Adult Crop    387 Adult Midgut    328.5 Adult Hindgut    395.8 Adult Malpighian Tubules    197.2 Adult Fat Body    219.9 Adult Salivary Gland    303 Adult Heart    219.225 Adult VirginFemale Spermatheca    147.4 Adult InseminatedFemale Spermatheca    190.7 Adult Ovary    730.6 Adult Testis    280.3 Adult Male Accessory Gland    412.5 Adult Carcass    188.6 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    629.575 Larval Midgut    289.8 Larval Hindgut    431.6 Larval Malpighian Tubules    277.1 Larval Fat Body    275.5 Larval Salivary Gland    438.6 Larval Trachea    607.6 Larval Carcass    418.95 Adult Head    242.2 Adult Eye    239.975 Adult Brain    302.4 Adult Thoracic-Abdominal Ganglion    317.8 Adult Crop    387 Adult Midgut    328.5 Adult Hindgut    395.8 Adult Malpighian Tubules    197.2 Adult Fat Body    219.9 Adult Salivary Gland    303 Adult Heart    219.225 Adult VirginFemale Spermatheca    147.4 Adult InseminatedFemale Spermatheca    190.7 Adult Ovary    730.6 Adult Testis    280.3 Adult Male Accessory Gland    412.5 Adult Carcass    188.6 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    242.2   NA  Eye    239.975   NA  Brain    302.4   629.575  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    317.8   NA  Crop    387   289.8  Midgut    328.5   431.6  Hindgut    395.8   277.1  Malpighian Tubules    197.2   275.5  Fat Body    219.9   438.6  Salivary Gland    303   NA  Heart    219.225   607.6  Trachea    NA   NA  VirginFemale Spermatheca    147.4   NA  InseminatedFemale Spermatheca    190.7   NA  Ovary    730.6   NA  Testis    280.3   NA  Male Accessory Gland    412.5   418.95  Carcass    188.6 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_03
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0037893 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG6719-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable CG6719e00315 viable, with Scer\GAL4pnr-MD237 CG6719GD12016 Sterility Allele fertile CG6719e00315 Other Phenotypes Allele visible, with Scer\GAL4pnr-MD237 CG6719GD12016 Phenotype manifest in Allele trichogen cell, with Scer\GAL4pnr-MD237 CG6719GD12016
Classical Alleles ( 2 )
For All Classical Alleles Show
Allele of CG6719 Class Mutagen Stocks Known lesion CG6719e00315 piggyBac transposase 2 -- CG6719G5308 P-element activity 1 --
Alleles Carried on Transgenic Constructs ( 1 )
For All Alleles Carried on Transgenic Constructs Show
Allele of CG6719 Class Mutagen Stocks Known lesion CG6719GD12016 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes
Aneuploid Aberrations
Disrupted in	Df(3R)Exel6160 (Ryder, 2004.4.26) Df(3R)Exel7308 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD12016} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions PBac{RB}CG6719e00315 NA insertion of mobile activating element P{EP}CG6719G5308 NA
Gene Ontology: Function, Process & Cellular Component ( 4 unique terms )
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 4 terms )
Molecular Function
CV term Evidence References
chaperone binding inferred from sequence or structural similarity with InterPro:IPR004127 (Swiss-Prot Project Members, 2000.10.1) unfolded protein binding inferred from electronic annotation with InterPro:IPR004127 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
'de novo' protein folding inferred from sequence or structural similarity with InterPro:IPR004127 (Swiss-Prot Project Members, 2000.10.1)
Cellular Component
CV term Evidence References
prefoldin complex inferred from sequence or structural similarity with InterPro:IPR004127 (Swiss-Prot Project Members, 2000.10.1)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions CG6719 allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 66498 DroID - A comprehensive database of gene and protein interactions. • FBgn0037893 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 41365
Orthologs
Genome-wide drosophilid orthologs	Dana\GF18161 Dere\GG17226 Dgri\GH24010 Dmoj\GI10062 Dper\GL12609 Dpse\GA19809 Dsec\GM26102 Dsim\GD20662 Dvir\GJ23797 Dwil\GK11798 Dyak\GE24626
Curated drosophilid orthologs	Dpse\GA19809
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL004427-PA Aedes aegypti (mosquito) AGAP011165-PA Anopheles gambiae (mosquito) XP_624282.1 Apis mellifera (honey bee) XP_001944529.1 Acyrthosiphon pisum (pea aphid) At5g49510.1 Arabidopsis thaliana (wall cress) 84536 Batrachochytrium dendrobatidis (chytrid fungus) 119757 Branchiostoma floridae (lancelet) XP_001898686.1 Brugia malayi (roundworm nematode) ENSBTAP00000044334 Bos taurus (bovine) CAL0003453 Candida albicans (a form of yeast) CBP09410 Caenorhabditis briggsae (nematode) CE13349 Caenorhabditis elegans (worm) ENSCAFP00000029046 Canis familiaris (dog) CAGL0K01177g Candida glabrata (haploid yeast) ENSCINP00000018884 Ciona intestinalis (sea squirt) JA03962 Caenorhabditis japonica (nematode) CMF141C Cyanidioschyzon merolae (red alga) cn04521 Cryptococcus neoformans (yeast-like fungus) cgd5_930 Cryptosporidium parvum (protozoan parasite) CPIJ013352 Culex pipens (mosquito) ENSCPOP00000012293 Cavia porcellus (guinea pig) 112797 Chlamidomonas reinhardtii (green alga) RP04548 Caenorhabditis remanei (nematode) 168351 Capitella spl (polychaete worm) DDB0237722 Dictyostelium discoideum (amoeba) DEHA2F16610g Debaryomyces Hansenii (yeast) 306350 Daphnia pulex (daphnia) ENSDARP00000053029 Danio rerio (zebra fish) ENSECAP00000001497 Equus caballus (horse) XP_656814 Entamoeba histolytica (anaerobic protozoan) ENSGACP00000002532 Gymnopilus aculeatus (mushroom) ENSGALP00000013653 Gallus gallus (chicken) GL50803_7030 Giardia lamblia (flagellated protozoan) 71753 Hypsipyla robusta (cedar shoot borer) ENSP00000286428 Homo sapiens (human) ISCW016281-PA Ixodes scapularis (deer tick) KLLA0C04510g Kluyveromyces lactis (yeast) 202995 Lottia gigantea (owl limpet) LmjF26.1380 Leishmania major (virus) 29713 Monocosta brevicollis (choanoflagellate) ENSMODP00000020596 Monodelphis domestica (gray opossum) ENSMMUP00000019779 Macaca mulatta (rhesus monkey) ENSMUSP00000033540 Mus musculus (house mouse) 176056 Nematostella vectensis (starlet anemone) XP_001599491.1 Nasonia vitripennis (wasp) ENSOANP00000002020 Ornithorynchus anatinus (platypus) ENSORLP00000010474 Oryzias latipes (japanese killifish) LOC_Os12g37590.1 Oryza sativa (asian rice) 20681 Ostreococcus tauri (green alga) MAL7P1.94 Plasmodium falciparum (protozoal parasite) PHUM005740-PA Pediculus humanus (human body louse) 221391 Physcomitrella patens (moss) ENSPPYP00000023400 Pongo pygmaeus (orangutan) 141993 Phytophthora sojae (root rot pathogen) 833669 Populus trichocarpa (black cottonwood) ENSPTRP00000038725 Pan troglodytes (chimpanzee) PVX_096400 Plasmodium vivax (protozoal parasite) 5059660 Sorghum bicolor (sorghum) YGR078C Saccharomyces cerevisiae (budding yeast) Smp_021800 Schistosoma mansoni (trematode parasite) SPAC3H8.07c Schizosaccharomyces pombe (fission yeast) XP_797937.1 Strongylocentrotus purpuratus (purple sea urchin) 25500 Trichoplax adhaerens (metazoa) TA06440 Theileria annulata (apicomplexan parasite) XP_968036.1 Tribolium castaneum (red flour beetle) Tc00.1047053506287.140 Trypanosoma cruzi (parasitic trypanosome) Tc00.1047053508881.120 Trypanosoma cruzi (parasitic trypanosome) ENSTNIP00000006277 Tetraodon nigroviridis (green spotted pufferfish) TP01_0927 Theileria parva (parasitic protozoan) 34994 Thalassiosira pseudonana (marine diatom) ENSTRUP00000007946 Takifugu rubripes (pufferfish Takifugu) 80222.m00173 Trichomonas vaginalis (parasitic flagellated protozoan) ENSXETP00000003195 Xenopus tropicalis (frog) YALI0B08844g Yarrowia lipolytica (nonconventional yeast) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB19493 NV16598 LH25127 ISCW016281 FBgn0241736 FBgn0213809 FBgn0210893 FBgn0192128 FBgn0180957 JGI_V11_306350 FBgn0079805 FBgn0150215 FBgn0132828 FBgn0131466 FBgn0109453 FBgn0095179 CPIJ013352 ACYPI004415 GB11898 AGAP011165 AAEL004427 PHUM106440 GLEAN_01098
Stocks & Reagents
Stocks Listed in FlyBase ( 4 )
Bloomington	17842 w1118; PBac{RB}CG6719e00315 30151 w1118; P{EP}CG6719G5308/TM6C, Sb1
Harvard	- PBac{RB}CG6719e00315
VDRC	v27727 w1118; P{GD12016}v27727
Genomic Clones ( 2 )
	BACR05C15 BACR13P08 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 101 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD34406
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GM01810 GM03531 GM05754 GM07817 GM30128 RE71445 RH24581 RH32658 RH35779 RH36356 RH37370 RH49778 RH59546
Other clones	79633 117525 Dmel_neb_015841_0702_1720 EC29941 EK236526 FGC017B12 FGM003C01 FGM305C09 FGM319C04 RP003002367 RP003008384 RP003022442 RP003023486 RP003031987 RP003041510 RP003042710 RP003047444 RP003081084 RP003089470 RP003102897 RP003121016 RP003124674 RP003125136 RP003125489 RP003126782 RP003133886 RP003134812 RP003136880 RP003149807 RP003153834 RP003160256 RP003167312 RP003167543 RP003172098 RP003172484 RP003177274 RP003184844 RP003249854 RP003254226 RP003254478 RP003255461 RP003256623 RP003260129 RP003282882 RP003292265 RP003310702 RP003324484 RP003330563 RP003333403 RP003365323 RP003386001 RP003403161 RP003409376 RP003416570 RP003428084 RP003429875 RP003450405 RP003454303 RP003455216 RP003456645 RP003459863 RP003462643 RP003472594 RP003485326 RP003498510 RP003503127 RP003504988 RP003513419 RP003529117 RP003533932 RP003547834 RP003551895 RP003562238 RP003565958 RP003585086 RP003585553 RP003587432 RP003607867 RP003610591 RP003619768 RP003627986 RP003629389 RP003639075 RP003655487 RP003666138 RP003667218 RP003679714
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0037893 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 41365
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_141810 RefSeq (Proteins) • NP_650067 DDBJ / EMBL / GenBank • AA990895 AAF54630 AAO25004 AW943231 BT003247 Entrez Gene - A searchable database of RefSeq genes. • 41365 UniProtKB/Swiss-Prot • Q9VGP6 UniProtKB/TrEMBL • Q86PA8
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Prefoldin subunit (IPR004127) Prefoldin (IPR009053) Prefoldin, subunit 3 (IPR016655)
Linkouts
	BioGRID - A database of protein and genetic interactions • 66498 DroID - A comprehensive database of gene and protein interactions. • FBgn0037893 DRSC - Results from RNAi screens. • FBgn0037893 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0037893 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG6719-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0037893 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 41365 InParanoid A subset of ortholog calls from InParanoid. • AAEL004427-PA Aedes aegypti (mosquito) AGAP011165-PA Anopheles gambiae (mosquito) XP_624282.1 Apis mellifera (honey bee) XP_001944529.1 Acyrthosiphon pisum (pea aphid) At5g49510.1 Arabidopsis thaliana (wall cress) 84536 Batrachochytrium dendrobatidis (chytrid fungus) 119757 Branchiostoma floridae (lancelet) XP_001898686.1 Brugia malayi (roundworm nematode) ENSBTAP00000044334 Bos taurus (bovine) CAL0003453 Candida albicans (a form of yeast) CBP09410 Caenorhabditis briggsae (nematode) CE13349 Caenorhabditis elegans (worm) ENSCAFP00000029046 Canis familiaris (dog) CAGL0K01177g Candida glabrata (haploid yeast) ENSCINP00000018884 Ciona intestinalis (sea squirt) JA03962 Caenorhabditis japonica (nematode) CMF141C Cyanidioschyzon merolae (red alga) cn04521 Cryptococcus neoformans (yeast-like fungus) cgd5_930 Cryptosporidium parvum (protozoan parasite) CPIJ013352 Culex pipens (mosquito) ENSCPOP00000012293 Cavia porcellus (guinea pig) 112797 Chlamidomonas reinhardtii (green alga) RP04548 Caenorhabditis remanei (nematode) 168351 Capitella spl (polychaete worm) DDB0237722 Dictyostelium discoideum (amoeba) DEHA2F16610g Debaryomyces Hansenii (yeast) 306350 Daphnia pulex (daphnia) ENSDARP00000053029 Danio rerio (zebra fish) ENSECAP00000001497 Equus caballus (horse) XP_656814 Entamoeba histolytica (anaerobic protozoan) ENSGACP00000002532 Gymnopilus aculeatus (mushroom) ENSGALP00000013653 Gallus gallus (chicken) GL50803_7030 Giardia lamblia (flagellated protozoan) 71753 Hypsipyla robusta (cedar shoot borer) ENSP00000286428 Homo sapiens (human) ISCW016281-PA Ixodes scapularis (deer tick) KLLA0C04510g Kluyveromyces lactis (yeast) 202995 Lottia gigantea (owl limpet) LmjF26.1380 Leishmania major (virus) 29713 Monocosta brevicollis (choanoflagellate) ENSMODP00000020596 Monodelphis domestica (gray opossum) ENSMMUP00000019779 Macaca mulatta (rhesus monkey) ENSMUSP00000033540 Mus musculus (house mouse) 176056 Nematostella vectensis (starlet anemone) XP_001599491.1 Nasonia vitripennis (wasp) ENSOANP00000002020 Ornithorynchus anatinus (platypus) ENSORLP00000010474 Oryzias latipes (japanese killifish) LOC_Os12g37590.1 Oryza sativa (asian rice) 20681 Ostreococcus tauri (green alga) MAL7P1.94 Plasmodium falciparum (protozoal parasite) PHUM005740-PA Pediculus humanus (human body louse) 221391 Physcomitrella patens (moss) ENSPPYP00000023400 Pongo pygmaeus (orangutan) 141993 Phytophthora sojae (root rot pathogen) 833669 Populus trichocarpa (black cottonwood) ENSPTRP00000038725 Pan troglodytes (chimpanzee) PVX_096400 Plasmodium vivax (protozoal parasite) 5059660 Sorghum bicolor (sorghum) YGR078C Saccharomyces cerevisiae (budding yeast) Smp_021800 Schistosoma mansoni (trematode parasite) SPAC3H8.07c Schizosaccharomyces pombe (fission yeast) XP_797937.1 Strongylocentrotus purpuratus (purple sea urchin) 25500 Trichoplax adhaerens (metazoa) TA06440 Theileria annulata (apicomplexan parasite) XP_968036.1 Tribolium castaneum (red flour beetle) Tc00.1047053506287.140 Trypanosoma cruzi (parasitic trypanosome) Tc00.1047053508881.120 Trypanosoma cruzi (parasitic trypanosome) ENSTNIP00000006277 Tetraodon nigroviridis (green spotted pufferfish) TP01_0927 Theileria parva (parasitic protozoan) 34994 Thalassiosira pseudonana (marine diatom) ENSTRUP00000007946 Takifugu rubripes (pufferfish Takifugu) 80222.m00173 Trichomonas vaginalis (parasitic flagellated protozoan) ENSXETP00000003195 Xenopus tropicalis (frog) YALI0B08844g Yarrowia lipolytica (nonconventional yeast) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 41365 modMine - Data generated by the modENCODE project. • FBgn0037893 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB19493 NV16598 LH25127 ISCW016281 FBgn0241736 FBgn0213809 FBgn0210893 FBgn0192128 FBgn0180957 JGI_V11_306350 FBgn0079805 FBgn0150215 FBgn0132828 FBgn0131466 FBgn0109453 FBgn0095179 CPIJ013352 ACYPI004415 GB11898 AGAP011165 AAEL004427 PHUM106440 GLEAN_01098
Synonyms & Secondary IDs ( 3 )
Reported As
Symbol Synonym	BcDNA:LD34406   CG6719 (Dorer et al., 2006, Still et al., 2004, Gandhi et al., 2007, Witsell et al., 2009) PAC10 (Dorer et al., 2006)
Name Synonym
Secondary FlyBase IDs
	FBgn0064920
References ( 18 )
Research paper	Blanco et al., 2010, BMC Dev. Biol. 10: 94 Gene expression following induction of regeneration in Drosophila wing imaginal discs. Expression profile of regenerating wing discs. [FBrf0211812] Witsell et al., 2009, Genetics 183(3): 1187--1193 Removal of the bloom syndrome DNA helicase extends the utility of imprecise transposon excision for making null mutations in Drosophila. [FBrf0209368] Dorer et al., 2006, PLoS Pathog. 2(4): RNA interference analysis of Legionella in Drosophila cells: exploitation of early secretory apparatus dynamics. [FBrf0194432] Still et al., 2004, BMC Evol. Biol. 4(1): 16 Structure-function evolution of the transforming acidic coiled coil genes revealed by analysis of phylogenetically diverse organisms. [FBrf0179960]
Supplementary material	The modENCODE Consortium, 2010, Science 330(6012): DataS14: Gene co-expression clusters. [FBrf0213979] Mummery-Widmer et al., 2009, Nature 458(7241): Supplementary Table 2 - Genome-wide bristle screen results. [FBrf0214518] Gandhi et al., 2007, Nat. Genet. 38(3): Supplementary Information [FBrf0208882] Giot et al., 2003, Science 302(5651): Tables S1 to S7. [FBrf0166452]
Personal communication to FlyBase	Bellen, 2010.2.16, BDGP_2010_0216.GenExel.xml BDGP_2010_0216.GenExel.xml [FBrf0210005] Dickson et al., 2007.7.18, RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0200327] Bloomington Drosophila Stock Center, 2004.11.6, Exelixis insertion alleles that are not in FlyBase. Exelixis insertion alleles that are not in FlyBase. [FBrf0179797] FlyBase Curators et al., 2004-, Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. [FBrf0174215] Ryder, 2004.4.26, Exelixis CG deletion data. Exelixis CG deletion data. [FBrf0184335]
FlyBase analysis	FlyBase, 1992-, FlyBase curation FlyBase curation. [FBrf0105495]
Protein sequence record	Swiss-Prot Project Members, 2000.10.1, UniProtKB: Q9VGP6 PROBABLE PREFOLDIN SUBUNIT 3. [FBrf0136239]
Computer file	BDGP Project Members, 2000-, Berkeley Drosophila Genome Project. Berkeley Drosophila Genome Project. [FBrf0125078]
Curated genome annotation	Beasley, 1999.11, [Annotations performed at the Celera Jamboreee.] [Annotations performed at the Celera Jamboreee.] [FBrf0126653]