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Gene Dmel\PGRP-LB

General Information
Symbol	Dmel\PGRP-LB	Species	D. melanogaster
Name	Peptidoglycan recognition protein LB	Annotation symbol	CG14704
Feature type	protein_coding_gene	FlyBase ID	FBgn0037906
Gene Model Status	Current	Stock availability	3 publicly available
Genomic Location
Chromosome (arm)	3R	Recombination map
Cytogenetic map	86E6-86E6	Sequence location	3R:7,278,571..7,286,274 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Peptidoglycan recognition protein LB is referred to in FlyBase by the symbol Dmel\PGRP-LB (CG14704, FBgn0037906). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: protein binding; N-acetylmuramoyl-L-alanine amidase activity. There is experimental evidence that it is involved in the biological process: defense response to Gram-positive bacterium; negative regulation of peptidoglycan recognition protein signaling pathway. 8 alleles are reported. No phenotypic data is available. It has 6 annotated transcripts and 6 annotated polypeptides. Protein features are: N-acetylmuramoyl-L-alanine amidase domain; Peptidoglycan recognition protein; Peptidoglycan recognition protein family domain, metazoa/bacteria; Peptidoglycan recognition protein, PGRP-S. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of extremely low expression. Peak expression observed within 18-24 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: larval/adult midgut. Expression at moderate levels in the following post-embryonic organs or tissues: adult crop, larval/adult hindgut, adult heart, larval/adult salivary gland. Comments on Affy2 ProbeSet: ProbeSet 1630741_s_at completely aligns to an exonic region common to each of the 3 FlyBase-annotated transcript isoforms of PGRP-LB. Gene sequence location is 3R:7278571..7286274.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 86E6-86E6   Limits computationally determined from genome sequence between P{PZ}tho1&P{PZ}l(3)0462905275 and P{EP}Lk6EP886
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\PGRP-LB for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.49
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) PGRP-LB-RA FBtr0082398  NM_141822   1129   215 PGRP-LB-RB FBtr0082397  NM_169393   1068   215 PGRP-LB-RC FBtr0082396  NM_169392   1255   232 PGRP-LB-RD FBtr0306097  NM_001260123   926   255 PGRP-LB-RE FBtr0306098  NM_001260124   925   215 PGRP-LB-RF FBtr0306099  NM_001260125   1234   215
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein PGRP-LB-PA   FBpp0081874   23.6   215   8.13     NP_650079   AAF54643 PGRP-LB-PB   FBpp0081873   23.6   215   8.13     NP_731576   AAN13506 PGRP-LB-PC   FBpp0081872   25.4   232   8.13     NP_731575   AAN13505 PGRP-LB-PD   FBpp0297234   27.8   255   7.15     NP_001247052   AFH06370 PGRP-LB-PE   FBpp0297235   23.6   215   8.13     NP_001247053   AFH06371 PGRP-LB-PF   FBpp0297236   23.6   215   8.13     NP_001247054   AFH06372
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • N-acetylmuramoyl-L-alanine amidase domain (IPR002502) Peptidoglycan recognition protein family domain, metazoa/bacteria (IPR006619) Peptidoglycan recognition protein (IPR015510) Peptidoglycan recognition protein, PGRP-S (IPR017331)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014297 AAF54643   AE014297 AAN13505   AE014297 AAN13506   AF207537 AAG23731   AF207538 AAG23732   AE014297 AFH06370   AE014297 AFH06371   AE014297 AFH06372   AI114389   AI389755   AW940806   AY060759 AAL28307   BI237829   BT011455   CA806167   EL886256
UniProtKB/Swiss-Prot	Q8INK6
UniProtKB/TrEMBL	A4V2P5
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 3   organism   (Fisher et al., 2012) Comment:maternally deposited embryonic stage 4 -- 6   organism   (Fisher et al., 2012)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
extracellular region inferred from direct assay (assigned by UniProtKB) (De Gregorio et al., 2002)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: larval/adult midgut. Expression at moderate levels in the following post-embryonic organs or tissues: adult crop, larval/adult hindgut, adult heart, larval/adult salivary gland. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    15.4 Larval Midgut    520.3 Larval Hindgut    159.3 Larval Malpighian Tubules    20.7 Larval Fat Body    37.6 Larval Salivary Gland    211.4 Larval Trachea    35.9 Larval Carcass    65.7 Adult Head    75.6 Adult Eye    48.3 Adult Brain    14.6 Adult Thoracic-Abdominal Ganglion    10.7 Adult Crop    418.1 Adult Midgut    601.8 Adult Hindgut    120.3 Adult Malpighian Tubules    15.4 Adult Fat Body    91.5 Adult Salivary Gland    411.8 Adult Heart    147.9 Adult VirginFemale Spermatheca    94.8 Adult InseminatedFemale Spermatheca    70.6 Adult Ovary    11.6 Adult Testis    15.1 Adult Male Accessory Gland    54.8 Adult Carcass    96.7 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    15.4 Larval Midgut  520.3 Larval Hindgut    159.3 Larval Malpighian Tubules    20.7 Larval Fat Body    37.6 Larval Salivary Gland    211.4 Larval Trachea    35.9 Larval Carcass    65.7 Adult Head    75.6 Adult Eye    48.3 Adult Brain    14.6 Adult Thoracic-Abdominal Ganglion    10.7 Adult Crop    418.1 Adult Midgut  (601.8) Adult Hindgut    120.3 Adult Malpighian Tubules    15.4 Adult Fat Body    91.5 Adult Salivary Gland    411.8 Adult Heart    147.9 Adult VirginFemale Spermatheca    94.8 Adult InseminatedFemale Spermatheca    70.6 Adult Ovary    11.6 Adult Testis    15.1 Adult Male Accessory Gland    54.8 Adult Carcass    96.7 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    15.4 Larval Midgut    520.3 Larval Hindgut    159.3 Larval Malpighian Tubules    20.7 Larval Fat Body    37.6 Larval Salivary Gland    211.4 Larval Trachea    35.9 Larval Carcass    65.7 Adult Head    75.6 Adult Eye    48.3 Adult Brain    14.6 Adult Thoracic-Abdominal Ganglion    10.7 Adult Crop    418.1 Adult Midgut    601.8 Adult Hindgut    120.3 Adult Malpighian Tubules    15.4 Adult Fat Body    91.5 Adult Salivary Gland    411.8 Adult Heart    147.9 Adult VirginFemale Spermatheca    94.8 Adult InseminatedFemale Spermatheca    70.6 Adult Ovary    11.6 Adult Testis    15.1 Adult Male Accessory Gland    54.8 Adult Carcass    96.7 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    15.4 Larval Midgut    520.3 Larval Hindgut    159.3 Larval Malpighian Tubules    20.7 Larval Fat Body    37.6 Larval Salivary Gland    211.4 Larval Trachea    35.9 Larval Carcass    65.7 Adult Head    75.6 Adult Eye    48.3 Adult Brain    14.6 Adult Thoracic-Abdominal Ganglion    10.7 Adult Crop    418.1 Adult Midgut    601.8 Adult Hindgut    120.3 Adult Malpighian Tubules    15.4 Adult Fat Body    91.5 Adult Salivary Gland    411.8 Adult Heart    147.9 Adult VirginFemale Spermatheca    94.8 Adult InseminatedFemale Spermatheca    70.6 Adult Ovary    11.6 Adult Testis    15.1 Adult Male Accessory Gland    54.8 Adult Carcass    96.7 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    15.4 Larval Midgut    520.3 Larval Hindgut    159.3 Larval Malpighian Tubules    20.7 Larval Fat Body    37.6 Larval Salivary Gland    211.4 Larval Trachea    35.9 Larval Carcass    65.7 Adult Head    75.6 Adult Eye    48.3 Adult Brain    14.6 Adult Thoracic-Abdominal Ganglion    10.7 Adult Crop    418.1 Adult Midgut    601.8 Adult Hindgut    120.3 Adult Malpighian Tubules    15.4 Adult Fat Body    91.5 Adult Salivary Gland    411.8 Adult Heart    147.9 Adult VirginFemale Spermatheca    94.8 Adult InseminatedFemale Spermatheca    70.6 Adult Ovary    11.6 Adult Testis    15.1 Adult Male Accessory Gland    54.8 Adult Carcass    96.7 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    15.4 Larval Midgut  520.3 Larval Hindgut    159.3 Larval Malpighian Tubules    20.7 Larval Fat Body    37.6 Larval Salivary Gland    211.4 Larval Trachea    35.9 Larval Carcass    65.7 Adult Head    75.6 Adult Eye    48.3 Adult Brain    14.6 Adult Thoracic-Abdominal Ganglion    10.7 Adult Crop    418.1 Adult Midgut  601.8 Adult Hindgut    120.3 Adult Malpighian Tubules    15.4 Adult Fat Body    91.5 Adult Salivary Gland    411.8 Adult Heart    147.9 Adult VirginFemale Spermatheca    94.8 Adult InseminatedFemale Spermatheca    70.6 Adult Ovary    11.6 Adult Testis    15.1 Adult Male Accessory Gland    54.8 Adult Carcass    96.7 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    15.4 Larval Midgut    520.3 Larval Hindgut    159.3 Larval Malpighian Tubules    20.7 Larval Fat Body    37.6 Larval Salivary Gland    211.4 Larval Trachea    35.9 Larval Carcass    65.7 Adult Head    75.6 Adult Eye    48.3 Adult Brain    14.6 Adult Thoracic-Abdominal Ganglion    10.7 Adult Crop    418.1 Adult Midgut    601.8 Adult Hindgut    120.3 Adult Malpighian Tubules    15.4 Adult Fat Body    91.5 Adult Salivary Gland    411.8 Adult Heart    147.9 Adult VirginFemale Spermatheca    94.8 Adult InseminatedFemale Spermatheca    70.6 Adult Ovary    11.6 Adult Testis    15.1 Adult Male Accessory Gland    54.8 Adult Carcass    96.7 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    15.4 Larval Midgut    520.3 Larval Hindgut    159.3 Larval Malpighian Tubules    20.7 Larval Fat Body    37.6 Larval Salivary Gland    211.4 Larval Trachea    35.9 Larval Carcass    65.7 Adult Head    75.6 Adult Eye    48.3 Adult Brain    14.6 Adult Thoracic-Abdominal Ganglion    10.7 Adult Crop    418.1 Adult Midgut    601.8 Adult Hindgut    120.3 Adult Malpighian Tubules    15.4 Adult Fat Body    91.5 Adult Salivary Gland    411.8 Adult Heart    147.9 Adult VirginFemale Spermatheca    94.8 Adult InseminatedFemale Spermatheca    70.6 Adult Ovary    11.6 Adult Testis    15.1 Adult Male Accessory Gland    54.8 Adult Carcass    96.7 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    75.6   NA  Eye    48.3   NA  Brain    14.6   15.4  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    no informative data   NA  Crop    418.1   520.3  Midgut    601.8   159.3  Hindgut    120.3   20.7  Malpighian Tubules    no informative data   37.6  Fat Body    91.5   211.4  Salivary Gland    411.8   NA  Heart    147.9   35.9  Trachea    NA   NA  VirginFemale Spermatheca    94.8   NA  InseminatedFemale Spermatheca    70.6   NA  Ovary    11.6   NA  Testis    15.1   NA  Male Accessory Gland    54.8   65.7  Carcass    96.7 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    10 central nervous system, larvae L3    1 central nervous system, pupae P8    0 head, virgin 1-day female    3 head, virgin 4-day female    4 head, virgin 20-day female    9 head, mated 1-day female    2 head, mated 4-day female    2 head, mated 20-day female    7 head, mated 1-day male    4 head, mated 4-day male    4 head, mated 20-day male    9 salivary gland, larvae L3 wandering    4 salivary gland, white prepupae    4 digestive system, larvae L3 wandering    47 digestive system, 1-day adult    61 digestive system, 4-day adult    50 digestive system, 20-day adult    47 fat body, larvae L3 wandering    4 fat body, white prepupae    3 fat body, pupae P8    3 carcass, larvae L3 wandering    4 carcass, 1-day adult    7 carcass, 4-day adult    7 carcass, 20-day adult    24 ovary, virgin 4-day female    2 ovary, mated 4-day female    2 testis, mated 4-day male    3 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    10 central nervous system, larvae L3    1 central nervous system, pupae P8    0 head, virgin 1-day female    3 head, virgin 4-day female    4 head, virgin 20-day female    9 head, mated 1-day female    2 head, mated 4-day female    2 head, mated 20-day female    7 head, mated 1-day male    4 head, mated 4-day male    4 head, mated 20-day male    9 salivary gland, larvae L3 wandering    4 salivary gland, white prepupae    4 digestive system, larvae L3 wandering  (47) digestive system, 1-day adult  (61) digestive system, 4-day adult  (50) digestive system, 20-day adult  (47) fat body, larvae L3 wandering    4 fat body, white prepupae    3 fat body, pupae P8    3 carcass, larvae L3 wandering    4 carcass, 1-day adult    7 carcass, 4-day adult    7 carcass, 20-day adult    24 ovary, virgin 4-day female    2 ovary, mated 4-day female    2 testis, mated 4-day male    3 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    10 central nervous system, larvae L3    1 central nervous system, pupae P8    0 head, virgin 1-day female    3 head, virgin 4-day female    4 head, virgin 20-day female    9 head, mated 1-day female    2 head, mated 4-day female    2 head, mated 20-day female    7 head, mated 1-day male    4 head, mated 4-day male    4 head, mated 20-day male    9 salivary gland, larvae L3 wandering    4 salivary gland, white prepupae    4 digestive system, larvae L3 wandering    47 digestive system, 1-day adult    61 digestive system, 4-day adult    50 digestive system, 20-day adult    47 fat body, larvae L3 wandering    4 fat body, white prepupae    3 fat body, pupae P8    3 carcass, larvae L3 wandering    4 carcass, 1-day adult    7 carcass, 4-day adult    7 carcass, 20-day adult    24 ovary, virgin 4-day female    2 ovary, mated 4-day female    2 testis, mated 4-day male    3 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    10 central nervous system, larvae L3    1 central nervous system, pupae P8    0 head, virgin 1-day female    3 head, virgin 4-day female    4 head, virgin 20-day female    9 head, mated 1-day female    2 head, mated 4-day female    2 head, mated 20-day female    7 head, mated 1-day male    4 head, mated 4-day male    4 head, mated 20-day male    9 salivary gland, larvae L3 wandering    4 salivary gland, white prepupae    4 digestive system, larvae L3 wandering    47 digestive system, 1-day adult    61 digestive system, 4-day adult    50 digestive system, 20-day adult    47 fat body, larvae L3 wandering    4 fat body, white prepupae    3 fat body, pupae P8    3 carcass, larvae L3 wandering    4 carcass, 1-day adult    7 carcass, 4-day adult    7 carcass, 20-day adult    24 ovary, virgin 4-day female    2 ovary, mated 4-day female    2 testis, mated 4-day male    3 accessory gland, mated 4-day male    2 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    10 central nervous system, larvae L3    1 central nervous system, pupae P8    0 head, virgin 1-day female    3 head, virgin 4-day female    4 head, virgin 20-day female    9 head, mated 1-day female    2 head, mated 4-day female    2 head, mated 20-day female    7 head, mated 1-day male    4 head, mated 4-day male    4 head, mated 20-day male    9 salivary gland, larvae L3 wandering    4 salivary gland, white prepupae    4 digestive system, larvae L3 wandering    47 digestive system, 1-day adult    61 digestive system, 4-day adult    50 digestive system, 20-day adult    47 fat body, larvae L3 wandering    4 fat body, white prepupae    3 fat body, pupae P8    3 carcass, larvae L3 wandering    4 carcass, 1-day adult    7 carcass, 4-day adult    7 carcass, 20-day adult    24 ovary, virgin 4-day female    2 ovary, mated 4-day female    2 testis, mated 4-day male    3 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    10 central nervous system, larvae L3    1 central nervous system, pupae P8    0 head, virgin 1-day female    3 head, virgin 4-day female    4 head, virgin 20-day female    9 head, mated 1-day female    2 head, mated 4-day female    2 head, mated 20-day female    7 head, mated 1-day male    4 head, mated 4-day male    4 head, mated 20-day male    9 salivary gland, larvae L3 wandering    4 salivary gland, white prepupae    4 digestive system, larvae L3 wandering  (47) digestive system, 1-day adult  (61) digestive system, 4-day adult  (50) digestive system, 20-day adult  (47) fat body, larvae L3 wandering    4 fat body, white prepupae    3 fat body, pupae P8    3 carcass, larvae L3 wandering    4 carcass, 1-day adult    7 carcass, 4-day adult    7 carcass, 20-day adult    24 ovary, virgin 4-day female    2 ovary, mated 4-day female    2 testis, mated 4-day male    3 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    10 central nervous system, larvae L3    1 central nervous system, pupae P8    0 head, virgin 1-day female    3 head, virgin 4-day female    4 head, virgin 20-day female    9 head, mated 1-day female    2 head, mated 4-day female    2 head, mated 20-day female    7 head, mated 1-day male    4 head, mated 4-day male    4 head, mated 20-day male    9 salivary gland, larvae L3 wandering    4 salivary gland, white prepupae    4 digestive system, larvae L3 wandering    47 digestive system, 1-day adult    61 digestive system, 4-day adult    50 digestive system, 20-day adult    47 fat body, larvae L3 wandering    4 fat body, white prepupae    3 fat body, pupae P8    3 carcass, larvae L3 wandering    4 carcass, 1-day adult    7 carcass, 4-day adult    7 carcass, 20-day adult    24 ovary, virgin 4-day female    2 ovary, mated 4-day female    2 testis, mated 4-day male    3 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    10 central nervous system, larvae L3    1 central nervous system, pupae P8    0 head, virgin 1-day female    3 head, virgin 4-day female    4 head, virgin 20-day female    9 head, mated 1-day female    2 head, mated 4-day female    2 head, mated 20-day female    7 head, mated 1-day male    4 head, mated 4-day male    4 head, mated 20-day male    9 salivary gland, larvae L3 wandering    4 salivary gland, white prepupae    4 digestive system, larvae L3 wandering    47 digestive system, 1-day adult    61 digestive system, 4-day adult    50 digestive system, 20-day adult    47 fat body, larvae L3 wandering    4 fat body, white prepupae    3 fat body, pupae P8    3 carcass, larvae L3 wandering    4 carcass, 1-day adult    7 carcass, 4-day adult    7 carcass, 20-day adult    24 ovary, virgin 4-day female    2 ovary, mated 4-day female    2 testis, mated 4-day male    3 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of extremely low expression. Peak expression observed within 18-24 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    2 embryo 16-18hr    4 embryo 18-20hr    16 embryo 20-22hr    62 embryo 22-24hr    44 larva L1    29 larva L2    30 larva L3 12hr old    16 larva L3 puffstage 1-2    24 larva L3 puffstage 3-6    27 larva L3 puffstage 7-9    16 white prepupae new    5 white prepupae 12hr    6 white prepupae 24hr    2 pupae 2d postWPP    2 pupae 3d postWPP    2 pupae 4d postWPP    6 adult male 01day    14 adult male 05day    15 adult male 30day    18 adult female 01day    16 adult female 05day    7 adult female 30day    12 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    2 embryo 16-18hr    4 embryo 18-20hr    16 embryo 20-22hr  (62) embryo 22-24hr  (44) larva L1  (29) larva L2  (30) larva L3 12hr old    16 larva L3 puffstage 1-2    24 larva L3 puffstage 3-6  (27) larva L3 puffstage 7-9    16 white prepupae new    5 white prepupae 12hr    6 white prepupae 24hr    2 pupae 2d postWPP    2 pupae 3d postWPP    2 pupae 4d postWPP    6 adult male 01day    14 adult male 05day    15 adult male 30day    18 adult female 01day    16 adult female 05day    7 adult female 30day    12 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    2 embryo 16-18hr    4 embryo 18-20hr    16 embryo 20-22hr    62 embryo 22-24hr    44 larva L1    29 larva L2    30 larva L3 12hr old    16 larva L3 puffstage 1-2    24 larva L3 puffstage 3-6    27 larva L3 puffstage 7-9    16 white prepupae new    5 white prepupae 12hr    6 white prepupae 24hr    2 pupae 2d postWPP    2 pupae 3d postWPP    2 pupae 4d postWPP    6 adult male 01day    14 adult male 05day    15 adult male 30day    18 adult female 01day    16 adult female 05day    7 adult female 30day    12 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    2 embryo 16-18hr    4 embryo 18-20hr    16 embryo 20-22hr    62 embryo 22-24hr    44 larva L1    29 larva L2    30 larva L3 12hr old    16 larva L3 puffstage 1-2    24 larva L3 puffstage 3-6    27 larva L3 puffstage 7-9    16 white prepupae new    5 white prepupae 12hr    6 white prepupae 24hr    2 pupae 2d postWPP    2 pupae 3d postWPP    2 pupae 4d postWPP    6 adult male 01day    14 adult male 05day    15 adult male 30day    18 adult female 01day    16 adult female 05day    7 adult female 30day    12 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    2 embryo 16-18hr    4 embryo 18-20hr    16 embryo 20-22hr    62 embryo 22-24hr    44 larva L1    29 larva L2    30 larva L3 12hr old    16 larva L3 puffstage 1-2    24 larva L3 puffstage 3-6    27 larva L3 puffstage 7-9    16 white prepupae new    5 white prepupae 12hr    6 white prepupae 24hr    2 pupae 2d postWPP    2 pupae 3d postWPP    2 pupae 4d postWPP    6 adult male 01day    14 adult male 05day    15 adult male 30day    18 adult female 01day    16 adult female 05day    7 adult female 30day    12 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    2 embryo 16-18hr    4 embryo 18-20hr    16 embryo 20-22hr  (62) embryo 22-24hr  (44) larva L1  29 larva L2  30 larva L3 12hr old    16 larva L3 puffstage 1-2    24 larva L3 puffstage 3-6  27 larva L3 puffstage 7-9    16 white prepupae new    5 white prepupae 12hr    6 white prepupae 24hr    2 pupae 2d postWPP    2 pupae 3d postWPP    2 pupae 4d postWPP    6 adult male 01day    14 adult male 05day    15 adult male 30day    18 adult female 01day    16 adult female 05day    7 adult female 30day    12 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    2 embryo 16-18hr    4 embryo 18-20hr    16 embryo 20-22hr    62 embryo 22-24hr    44 larva L1    29 larva L2    30 larva L3 12hr old    16 larva L3 puffstage 1-2    24 larva L3 puffstage 3-6    27 larva L3 puffstage 7-9    16 white prepupae new    5 white prepupae 12hr    6 white prepupae 24hr    2 pupae 2d postWPP    2 pupae 3d postWPP    2 pupae 4d postWPP    6 adult male 01day    14 adult male 05day    15 adult male 30day    18 adult female 01day    16 adult female 05day    7 adult female 30day    12 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    2 embryo 16-18hr    4 embryo 18-20hr    16 embryo 20-22hr    62 embryo 22-24hr    44 larva L1    29 larva L2    30 larva L3 12hr old    16 larva L3 puffstage 1-2    24 larva L3 puffstage 3-6    27 larva L3 puffstage 7-9    16 white prepupae new    5 white prepupae 12hr    6 white prepupae 24hr    2 pupae 2d postWPP    2 pupae 3d postWPP    2 pupae 4d postWPP    6 adult male 01day    14 adult male 05day    15 adult male 30day    18 adult female 01day    16 adult female 05day    7 adult female 30day    12 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    1 embryonic 1182-4H    0 embryonic GM2    2 embryonic Kc167    0 embryonic S1    21 embryonic S3    0 leg disc CME L1    1 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    5 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    2 antennal disc ML-DmD20-c5    3 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    6 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    1 ovary fGS/OSS    0 ovary OSC    2 ovary OSS    3 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    1 embryonic 1182-4H    0 embryonic GM2    2 embryonic Kc167    0 embryonic S1    21 embryonic S3    0 leg disc CME L1    1 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    5 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    2 antennal disc ML-DmD20-c5    3 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    6 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    1 ovary fGS/OSS    0 ovary OSC    2 ovary OSS    3 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    1 embryonic 1182-4H    0 embryonic GM2    2 embryonic Kc167    0 embryonic S1    21 embryonic S3    0 leg disc CME L1    1 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    5 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    2 antennal disc ML-DmD20-c5    3 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    6 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    1 ovary fGS/OSS    0 ovary OSC    2 ovary OSS    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    1 embryonic 1182-4H    0 embryonic GM2    2 embryonic Kc167    0 embryonic S1    21 embryonic S3    0 leg disc CME L1    1 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    5 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    2 antennal disc ML-DmD20-c5    3 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    6 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    1 ovary fGS/OSS    0 ovary OSC    2 ovary OSS    3 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    1 embryonic 1182-4H    0 embryonic GM2    2 embryonic Kc167    0 embryonic S1    21 embryonic S3    0 leg disc CME L1    1 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    5 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    2 antennal disc ML-DmD20-c5    3 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    6 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    1 ovary fGS/OSS    0 ovary OSC    2 ovary OSS    3 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    1 embryonic 1182-4H    0 embryonic GM2    2 embryonic Kc167    0 embryonic S1    21 embryonic S3    0 leg disc CME L1    1 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    5 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    2 antennal disc ML-DmD20-c5    3 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    6 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    1 ovary fGS/OSS    0 ovary OSC    2 ovary OSS    3 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    1 embryonic 1182-4H    0 embryonic GM2    2 embryonic Kc167    0 embryonic S1    21 embryonic S3    0 leg disc CME L1    1 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    5 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    2 antennal disc ML-DmD20-c5    3 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    6 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    1 ovary fGS/OSS    0 ovary OSC    2 ovary OSS    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    1 embryonic 1182-4H    0 embryonic GM2    2 embryonic Kc167    0 embryonic S1    21 embryonic S3    0 leg disc CME L1    1 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    5 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    2 antennal disc ML-DmD20-c5    3 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    6 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    1 ovary fGS/OSS    0 ovary OSC    2 ovary OSS    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    8 cold shock, 4-day adult    7 heat shock, 4-day adult    8 Cadmium 50 mM 6 hrs, larvae L3    22 Cadmium 50 mM 12 hrs, larvae L3    18 Cadmium 50 mM 48 hrs, 4-day adult    14 Cadmium 100 mM 48 hrs, 4-day adult    7 Copper 0.5 mM 12 hrs, larvae L3    6 Copper 15 mM 48 hrs, 4-day adult    6 Zinc 5 mM 12 hrs, larvae L3    10 Zinc 4.5 mM 48 hrs, 4-day adult    9 Ethanol 2.5% 3 hrs, larvae L3    9 Ethanol 5% 3 hrs, larvae L3    17 Ethanol 10% 3 hrs, larvae L3    16 Caffeine 1.5 mg/ml 4 hrs, larvae L3    24 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    8 Caffeine 25 mg/ml 48 hrs, 4-day adult    6 Paraquat 5 mM 48 hrs, 4-day adult    6 Paraquat 10 mM 48 hrs, 4-day adult    9 Rotenone 2 μg 12 hrs, larvae L3    26 Rotenone 8 μg 12 hrs, larvae L3    22 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    8 cold shock, 4-day adult    7 heat shock, 4-day adult    8 Cadmium 50 mM 6 hrs, larvae L3    22 Cadmium 50 mM 12 hrs, larvae L3    18 Cadmium 50 mM 48 hrs, 4-day adult    14 Cadmium 100 mM 48 hrs, 4-day adult    7 Copper 0.5 mM 12 hrs, larvae L3    6 Copper 15 mM 48 hrs, 4-day adult    6 Zinc 5 mM 12 hrs, larvae L3    10 Zinc 4.5 mM 48 hrs, 4-day adult    9 Ethanol 2.5% 3 hrs, larvae L3    9 Ethanol 5% 3 hrs, larvae L3    17 Ethanol 10% 3 hrs, larvae L3    16 Caffeine 1.5 mg/ml 4 hrs, larvae L3    24 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    8 Caffeine 25 mg/ml 48 hrs, 4-day adult    6 Paraquat 5 mM 48 hrs, 4-day adult    6 Paraquat 10 mM 48 hrs, 4-day adult    9 Rotenone 2 μg 12 hrs, larvae L3  26 Rotenone 8 μg 12 hrs, larvae L3    22 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    8 cold shock, 4-day adult    7 heat shock, 4-day adult    8 Cadmium 50 mM 6 hrs, larvae L3    22 Cadmium 50 mM 12 hrs, larvae L3    18 Cadmium 50 mM 48 hrs, 4-day adult    14 Cadmium 100 mM 48 hrs, 4-day adult    7 Copper 0.5 mM 12 hrs, larvae L3    6 Copper 15 mM 48 hrs, 4-day adult    6 Zinc 5 mM 12 hrs, larvae L3    10 Zinc 4.5 mM 48 hrs, 4-day adult    9 Ethanol 2.5% 3 hrs, larvae L3    9 Ethanol 5% 3 hrs, larvae L3    17 Ethanol 10% 3 hrs, larvae L3    16 Caffeine 1.5 mg/ml 4 hrs, larvae L3    24 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    8 Caffeine 25 mg/ml 48 hrs, 4-day adult    6 Paraquat 5 mM 48 hrs, 4-day adult    6 Paraquat 10 mM 48 hrs, 4-day adult    9 Rotenone 2 μg 12 hrs, larvae L3    26 Rotenone 8 μg 12 hrs, larvae L3    22 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    8 cold shock, 4-day adult    7 heat shock, 4-day adult    8 Cadmium 50 mM 6 hrs, larvae L3    22 Cadmium 50 mM 12 hrs, larvae L3    18 Cadmium 50 mM 48 hrs, 4-day adult    14 Cadmium 100 mM 48 hrs, 4-day adult    7 Copper 0.5 mM 12 hrs, larvae L3    6 Copper 15 mM 48 hrs, 4-day adult    6 Zinc 5 mM 12 hrs, larvae L3    10 Zinc 4.5 mM 48 hrs, 4-day adult    9 Ethanol 2.5% 3 hrs, larvae L3    9 Ethanol 5% 3 hrs, larvae L3    17 Ethanol 10% 3 hrs, larvae L3    16 Caffeine 1.5 mg/ml 4 hrs, larvae L3    24 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    8 Caffeine 25 mg/ml 48 hrs, 4-day adult    6 Paraquat 5 mM 48 hrs, 4-day adult    6 Paraquat 10 mM 48 hrs, 4-day adult    9 Rotenone 2 μg 12 hrs, larvae L3    26 Rotenone 8 μg 12 hrs, larvae L3    22 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    8 cold shock, 4-day adult    7 heat shock, 4-day adult    8 Cadmium 50 mM 6 hrs, larvae L3    22 Cadmium 50 mM 12 hrs, larvae L3    18 Cadmium 50 mM 48 hrs, 4-day adult    14 Cadmium 100 mM 48 hrs, 4-day adult    7 Copper 0.5 mM 12 hrs, larvae L3    6 Copper 15 mM 48 hrs, 4-day adult    6 Zinc 5 mM 12 hrs, larvae L3    10 Zinc 4.5 mM 48 hrs, 4-day adult    9 Ethanol 2.5% 3 hrs, larvae L3    9 Ethanol 5% 3 hrs, larvae L3    17 Ethanol 10% 3 hrs, larvae L3    16 Caffeine 1.5 mg/ml 4 hrs, larvae L3    24 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    8 Caffeine 25 mg/ml 48 hrs, 4-day adult    6 Paraquat 5 mM 48 hrs, 4-day adult    6 Paraquat 10 mM 48 hrs, 4-day adult    9 Rotenone 2 μg 12 hrs, larvae L3    26 Rotenone 8 μg 12 hrs, larvae L3    22 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    8 cold shock, 4-day adult    7 heat shock, 4-day adult    8 Cadmium 50 mM 6 hrs, larvae L3    22 Cadmium 50 mM 12 hrs, larvae L3    18 Cadmium 50 mM 48 hrs, 4-day adult    14 Cadmium 100 mM 48 hrs, 4-day adult    7 Copper 0.5 mM 12 hrs, larvae L3    6 Copper 15 mM 48 hrs, 4-day adult    6 Zinc 5 mM 12 hrs, larvae L3    10 Zinc 4.5 mM 48 hrs, 4-day adult    9 Ethanol 2.5% 3 hrs, larvae L3    9 Ethanol 5% 3 hrs, larvae L3    17 Ethanol 10% 3 hrs, larvae L3    16 Caffeine 1.5 mg/ml 4 hrs, larvae L3    24 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    8 Caffeine 25 mg/ml 48 hrs, 4-day adult    6 Paraquat 5 mM 48 hrs, 4-day adult    6 Paraquat 10 mM 48 hrs, 4-day adult    9 Rotenone 2 μg 12 hrs, larvae L3  26 Rotenone 8 μg 12 hrs, larvae L3    22 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    8 cold shock, 4-day adult    7 heat shock, 4-day adult    8 Cadmium 50 mM 6 hrs, larvae L3    22 Cadmium 50 mM 12 hrs, larvae L3    18 Cadmium 50 mM 48 hrs, 4-day adult    14 Cadmium 100 mM 48 hrs, 4-day adult    7 Copper 0.5 mM 12 hrs, larvae L3    6 Copper 15 mM 48 hrs, 4-day adult    6 Zinc 5 mM 12 hrs, larvae L3    10 Zinc 4.5 mM 48 hrs, 4-day adult    9 Ethanol 2.5% 3 hrs, larvae L3    9 Ethanol 5% 3 hrs, larvae L3    17 Ethanol 10% 3 hrs, larvae L3    16 Caffeine 1.5 mg/ml 4 hrs, larvae L3    24 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    8 Caffeine 25 mg/ml 48 hrs, 4-day adult    6 Paraquat 5 mM 48 hrs, 4-day adult    6 Paraquat 10 mM 48 hrs, 4-day adult    9 Rotenone 2 μg 12 hrs, larvae L3    26 Rotenone 8 μg 12 hrs, larvae L3    22 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    8 cold shock, 4-day adult    7 heat shock, 4-day adult    8 Cadmium 50 mM 6 hrs, larvae L3    22 Cadmium 50 mM 12 hrs, larvae L3    18 Cadmium 50 mM 48 hrs, 4-day adult    14 Cadmium 100 mM 48 hrs, 4-day adult    7 Copper 0.5 mM 12 hrs, larvae L3    6 Copper 15 mM 48 hrs, 4-day adult    6 Zinc 5 mM 12 hrs, larvae L3    10 Zinc 4.5 mM 48 hrs, 4-day adult    9 Ethanol 2.5% 3 hrs, larvae L3    9 Ethanol 5% 3 hrs, larvae L3    17 Ethanol 10% 3 hrs, larvae L3    16 Caffeine 1.5 mg/ml 4 hrs, larvae L3    24 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    8 Caffeine 25 mg/ml 48 hrs, 4-day adult    6 Paraquat 5 mM 48 hrs, 4-day adult    6 Paraquat 10 mM 48 hrs, 4-day adult    9 Rotenone 2 μg 12 hrs, larvae L3    26 Rotenone 8 μg 12 hrs, larvae L3    22 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_20 mE1_20_mRNA_expression_cluster_16
External Data & Images
Linkouts	BDGP expression data • GH21008 RE34140 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0037906 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG14704-RC
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal | pupal stage | heat sensitive, with Scer\GAL4da.G32 PGRP-LB500.dsRNA.Scer\UAS viable PGRP-LBΔ viable, with Scer\GAL4pnr-MD237 PGRP-LBGD5166 Sterility Allele fertile PGRP-LBΔ Other Phenotypes Allele immune response defective PGRP-LBΔ immune response defective, with Scer\GAL4da.G32 PGRP-LB500.dsRNA.Scer\UAS immune response defective (with Df(3L)PGRP-SC1Δ) PGRP-LBΔ immune response defective (with Df(3R)Exel8153) PGRP-LBΔ short lived PGRP-LBΔ short lived (with Df(3L)PGRP-SC1Δ) PGRP-LBΔ Phenotype manifest in Allele
Classical Alleles ( 2 )
For All Classical Alleles Show
Allele of PGRP-LB Class Mutagen Stocks Known lesion PGRP-LBMI03733 1 -- PGRP-LBΔ gene targeting by homologous recombination 0 Yes
Alleles Carried on Transgenic Constructs ( 6 )
For All Alleles Carried on Transgenic Constructs Show
Allele of PGRP-LB Class Mutagen Stocks Known lesion PGRP-LBGD5166 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes PGRP-LBKK110099 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes PGRP-LB500.dsRNA.Scer\UAS in vitro construct - regulatory fusion in vitro construct - RNAi 0 Yes PGRP-LBNIG.14704R 0 -- PGRP-LBScer\UAS.cGa in vitro construct - regulatory fusion 0 Yes PGRP-LBScer\UAS.T:Avic\GFP-YFP in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3R)Exel6160 (Ryder, 2004.4.26) Df(3R)Exel8153 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD5166} NA P{KK110099} NA P{UAS-PGRP-LB.500} NA P{UAS-PGRP-LB.G} NA P{UAS-PGRP-LB.YFP} NA characterization construct P{NIG.14704R} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions Mi{MIC}PGRP-LBMI03733 NA
Gene Ontology: Function, Process & Cellular Component ( 14 unique terms )
Terms Based on Experimental Evidence ( 5 terms )
Molecular Function
CV term Evidence References
N-acetylmuramoyl-L-alanine amidase activity inferred from direct assay (Zaidman-Remy et al., 2006) protein binding inferred from physical interaction with CG16790 (assigned by UniProtKB) (Kim et al., 2003)
Biological Process
CV term Evidence References
defense response to Gram-positive bacterium inferred from direct assay (assigned by UniProtKB) (De Gregorio et al., 2002) negative regulation of peptidoglycan recognition protein signaling pathway inferred from direct assay (Zaidman-Remy et al., 2006)
Cellular Component
CV term Evidence References
extracellular region inferred from direct assay (assigned by UniProtKB) (De Gregorio et al., 2002)
Terms Based on Predictions or Assertions ( 9 terms )
Molecular Function
CV term Evidence References
amidase activity non-traceable author statement (Steiner, 2004) peptidoglycan binding inferred from sequence or structural similarity with UniProtKB:O76537 (Werner et al., 2000) non-traceable author statement (Werner, 1999.11.19, Lemaitre, 2000.12.20) traceable author statement (Steiner, 2004) zinc ion binding inferred from electronic annotation with InterPro:IPR006619 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
defense response non-traceable author statement (Lemaitre, 2000.12.20) detection of bacterium non-traceable author statement (Werner, 1999.11.19) immune response inferred from sequence or structural similarity with UniProtKB:O76537 (Werner et al., 2000) peptidoglycan catabolic process inferred from electronic annotation with InterPro:IPR002502, InterPro:IPR006619, InterPro:IPR015510 (FlyBase Curators et al., 2004-) peptidoglycan metabolic process non-traceable author statement (Steiner, 2004)
Cellular Component
CV term Evidence References
integral to plasma membrane non-traceable author statement (Lemaitre, 2000.12.20)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
PGRP-LB - CG6833 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) PGRP-LB - Hrb98DE experimental knowledge based (Guruharsha et al., 2011) PGRP-LB - Smn anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions PGRP-LB allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 66511 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0037906 DroID - A comprehensive database of gene and protein interactions. • FBgn0037906 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 41379
Orthologs
OrthoDB Orthologs (94) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6G7CJP Dipteran inclusive ortholog search EOG608NJ3 Insect inclusive ortholog search EOG6T4BRW Arthropod inclusive ortholog search EOG6VX0NG Metazoa inclusive ortholog search EOG6VMT94
Orthologs in Drosophila Species (EOG6G7CJP)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\PGRP-LB     Drosophila simulans   Dsim\GD15111 Y   Drosophila sechellia   Dsec\GM26096 Y   Drosophila erecta   Dere\GG17219 Y   Drosophila yakuba   Dyak\GE24618 Y   Drosophila ananassae   Dana\GF16643 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA13189 Y   Drosophila persimilis   Dper\GL12268 Y   Drosophila willistoni   Dwil\GK11791 Y   Drosophila virilis   Dvir\GJ10054 Y   Drosophila mojavensis   Dmoj\GI22456 Y   Drosophila grimshawi   Dgri\GH15357 Y
Orthologs in non-Drosophila Dipterans (EOG608NJ3)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL010171   Anopheles gambiae Malaria mosquito  Agam\PGRPLB   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ006716
Orthologs in non-Dipteran Insects (EOG6T4BRW)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\PGRP-LC Y Apis mellifera Western honey bee  Amel\Pgrp-s2 Y Apis mellifera Western honey bee  Amel\GB47804 Y Apis mellifera Western honey bee  Amel\PGRP-S3 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG016162 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG016161 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG018589 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG016159 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG016164 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG016156 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG016157 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG007725 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG016163 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG000015 Y Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH17636 Y Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH17637 Y Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH10739 Y Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH18862 Y Atta cephalotes Leafcutter ant  Acep\ACEP13585 Y Atta cephalotes Leafcutter ant  Acep\ACEP15367 Y Atta cephalotes Leafcutter ant  Acep\ACEP25125 Y Atta cephalotes Leafcutter ant  Acep\ACEP15380 Y Camponotus floridanus Florida carpenter ant  Cflo\CFLO23127 Y Camponotus floridanus Florida carpenter ant  Cflo\CFLO22729 Y Camponotus floridanus Florida carpenter ant  Cflo\CFLO23128 Y Camponotus floridanus Florida carpenter ant  Cflo\CFLO18932 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL18752 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL18751 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL19536 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL18243 Y Linepithema humile Argentine ant  Lhum\LH18471 Y Linepithema humile Argentine ant  Lhum\LH22370 Y Linepithema humile Argentine ant  Lhum\LH23955 Y Linepithema humile Argentine ant  Lhum\LH26258 Y Linepithema humile Argentine ant  Lhum\LH26259 Y Pogonomyrmex barbatus Red harvester ant  Pbar\PB27216 Y Pogonomyrmex barbatus Red harvester ant  Pbar\PB27215 Y Pogonomyrmex barbatus Red harvester ant  Pbar\PB17278 Y Pogonomyrmex barbatus Red harvester ant  Pbar\PB22743 Y Pogonomyrmex barbatus Red harvester ant  Pbar\PB23590 Y Solenopsis invicta Red fire ant  Sinv\SINV10240 Y Solenopsis invicta Red fire ant  Sinv\SINV24386 Y Solenopsis invicta Red fire ant  Sinv\SINV23762 Y Bombyx mori Silkmoth  Bmor\BGIBMGA012866 Y Bombyx mori Silkmoth  Bmor\BGIBMGA008038 Y Bombyx mori Silkmoth  Bmor\BGIBMGA007987 Y Bombyx mori Silkmoth  Bmor\BGIBMGA000673 Y Pediculus humanus Human body louse  Phum\PHUM581030 Y Tribolium castaneum Red flour beetle  Tcas\GLEAN_15689 Y Tribolium castaneum Red flour beetle  Tcas\TC002790 Y Tribolium castaneum Red flour beetle  Tcas\TC013620 Y Tribolium castaneum Red flour beetle  Tcas\TC010611 Y
Orthologs in non-Insect Arthropods (EOG6VX0NG)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Ixodes scapularis Deer tick  Isca\ISCW024175 Y Ixodes scapularis Deer tick  Isca\ISCW004389 Y Ixodes scapularis Deer tick  Isca\ISCW024689 Y Ixodes scapularis Deer tick  Isca\ISCW022212 Y
Orthologs in non-Arthropod Metazoa (EOG6VMT94)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_007946gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_003882gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_000222gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_023247gn Y Danio rerio Zebrafish  Drer\pglyrp2 Y Danio rerio Zebrafish  Drer\pglyrp6 Y Xenopus tropicalis Western clawed frog  Xtro\pglyrp1 Y Xenopus tropicalis Western clawed frog  Xtro\pglyrp2 Y Xenopus tropicalis Western clawed frog  Xtro\pglyrp1 Y Mus musculus House mouse  Mmus\Pglyrp1 Y Mus musculus House mouse  Mmus\Pglyrp3 Y Mus musculus House mouse  Mmus\ENSMUSG00000079563 Y Mus musculus House mouse  Mmus\Pglyrp4 Y Rattus norvegicus Norway rat  Rnor\Pglyrp4 Y Rattus norvegicus Norway rat  Rnor\ENSRNOG00000012291 Y Rattus norvegicus Norway rat  Rnor\ENSRNOG00000042606 Y Rattus norvegicus Norway rat  Rnor\LOC687320 Y Rattus norvegicus Norway rat  Rnor\Pglyrp1 Y Rattus norvegicus Norway rat  Rnor\Pglyrp3 Y Homo sapiens Human  Hsap\PGLYRP2 Y Homo sapiens Human  Hsap\PGLYRP3 Y Homo sapiens Human  Hsap\PGLYRP4 Y Homo sapiens Human  Hsap\PGLYRP1 Y
Human Orthologs (4)
Gene OMIM HGNC Hsap\PGLYRP2     Hsap\PGLYRP3     Hsap\PGLYRP4     Hsap\PGLYRP1
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD15111 Drosophila sechellia Dsec\GM26096 Drosophila erecta Dere\GG17219 Drosophila yakuba Dyak\GE24618 Drosophila ananassae Dana\GF16643 Drosophila pseudoobscura pseudoobscura Dpse\GA13189 Drosophila persimilis Dper\GL12268 Drosophila willistoni Dwil\GK11791 Drosophila virilis Dvir\GJ10054 Drosophila mojavensis Dmoj\GI22456 Drosophila grimshawi Dgri\GH15357
Stocks & Reagents
Stocks Listed in FlyBase ( 3 )
Bloomington	37079 y1 w*; Mi{MIC}PGRP-LBMI03733 CG17230MI03733/TM3, Sb1 Ser1
VDRC	v104557 P{KK110099}VIE-260B v13159 w1118 P{GD5166}v13159
Genomic Clones ( 1 )
	BACR13P08 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 6 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GH21008 RE34140
Other clones	DPiM_GH21008
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH11251
Other clones	ESG012b.E21.1_A07 IP17534
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0037906 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 41379
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: PGRP-LB CG14704 (FlyBase, 1996-)
Source for database merge of
Additional comments	Source for identity of PGRP-LB CG14704 was sequence comparison (date:001020). (FlyBase, 1996-)
Other Comments
	PGRP-LB down-regulates the imd pathway during local immune response. (Zaidman-Remy et al., 2006)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_141822 NM_169392 NM_169393 NM_001260123 NM_001260124 NM_001260125 RefSeq (Proteins) • NP_650079 NP_731575 NP_731576 NP_001247052 NP_001247053 NP_001247054 DDBJ / EMBL / GenBank • AAF54643 AAG23731 AAG23732 AAL28307 AAN13505 AAN13506 AF207537 AF207538 AFH06370 AFH06371 AFH06372 AI114389 AI389755 AW940806 AY060759 BI237829 Entrez Gene - A searchable database of RefSeq genes. • 41379 UniProtKB/Swiss-Prot • Q8INK6 UniProtKB/TrEMBL • A4V2P5
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • N-acetylmuramoyl-L-alanine amidase domain (IPR002502) Peptidoglycan recognition protein family domain, metazoa/bacteria (IPR006619) Peptidoglycan recognition protein (IPR015510) Peptidoglycan recognition protein, PGRP-S (IPR017331) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • GH21008 RE34140
Linkouts
	BioGRID - A database of protein and genetic interactions • 66511 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0037906 DroID - A comprehensive database of gene and protein interactions. • FBgn0037906 DRSC - Results from RNAi screens. • FBgn0037906 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0037906 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG14704-RC FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0037906 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 41379 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 41379 modMine - Data generated by the modENCODE project. • FBgn0037906
Synonyms & Secondary IDs ( 4 )
Reported As
Symbol Synonym	CG14704 (Pal et al., 2007, Irving et al., 2001, De Gregorio et al., 2001, Lemaitre, 2000.12.20, Valanne et al., 2007, Gendrin et al., 2009, Keleman et al., 2009.8.5, Hernandez-Romano et al., 2008, Douglas et al., 2011) PGRP-LB (Pal et al., 2007, Zaidman-Remy et al., 2007, Ha et al., 2009, Waterhouse et al., 2007, Christophides et al., 2002, Gendrin et al., 2009, Ryu et al., 2008, Zaidman-Remy et al., 2006, Neyen et al., 2012, Lee and Edery, 2008, Lhocine et al., 2008, Buchon et al., 2009, Sackton et al., 2007, Kim et al., 2005, Wagner et al., 2008, Wertheim et al., 2005, Curtis et al., 2007, Reiser et al., 2004, Zaidman-Rémy et al., 2011, Douglas et al., 2011, Paredes et al., 2011, Bosco-Drayon et al., 2012)
Name Synonym	Peptidoglycan recognition protein LB   Peptidoglycan-recognition protein-LB precursor (Hernandez-Romano et al., 2008)
Secondary FlyBase IDs
References ( 54 )
Generate a list of	All references relating to this gene ( 54 )
List References by type	Research paper  ( 33 ) Supplementary material  ( 5 ) Review  ( 1 ) Personal communication to FlyBase  ( 8 ) Abstract  ( 1 ) FlyBase analysis  ( 2 ) DNA/RNA sequence record  ( 2 ) Website  ( 1 ) Curated genome annotation  ( 1 )
Recent research papers ( 6 )
	Bosco-Drayon et al., 2012, Cell Host Microbe 12(2): 153--165 Peptidoglycan Sensing by the Receptor PGRP-LE in the Drosophila Gut Induces Immune Responses to Infectious Bacteria and Tolerance to Microbiota. [FBrf0219236] Neyen et al., 2012, J. Immunol. 189(4): 1886--1897 Tissue- and Ligand-Specific Sensing of Gram-Negative Infection in Drosophila by PGRP-LC Isoforms and PGRP-LE. [FBrf0219094] Sebald et al., 2012, PLoS ONE 7(8): e43144 CHD1 Contributes to Intestinal Resistance against Infection by P. aeruginosa in Drosophila melanogaster. [FBrf0219215] Douglas et al., 2011, Proc. Biol. Sci. 278(1704): 333--338 How the insect immune system interacts with an obligate symbiotic bacterium. [FBrf0212672] Paredes et al., 2011, Immunity 35(5): 770--779 Negative Regulation by Amidase PGRPs Shapes the Drosophila Antibacterial Response and Protects the Fly from Innocuous Infection. [FBrf0216727] Zaidman-Rémy et al., 2011, PLoS ONE 6(2): e17231 Drosophila Immunity: Analysis of PGRP-SB1 Expression, Enzymatic Activity and Function. [FBrf0213192] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...