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Gene Dmel\CG10898

General Information
Symbol	Dmel\CG10898	Species	D. melanogaster
Name		Annotation symbol	CG10898
Feature type	protein_coding_gene	FlyBase ID	FBgn0037911
Gene Model Status	Current	Stock availability	10 publicly available
Genomic Location
Chromosome (arm)	3R	Recombination map
Cytogenetic map	86E10-86E10	Sequence location	3R:7,383,451..7,385,599 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	This gene is referred to in FlyBase by the symbol Dmel\CG10898 (FBgn0037911). It is a protein_coding_gene from Drosophila melanogaster. An electronic pipeline based on InterPro domains suggests that it has the molecular function: hydrolase activity. Based on sequence similarity, it is predicted to be involved in the biological process: DNA repair. 7 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: NUDIX hydrolase; NUDIX hydrolase domain; NUDIX hydrolase domain-like; NUDIX hydrolase, conserved site. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of low expression. Peak expression observed during late pupal stages. Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: larval trachea. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, adult central nervous system, adult crop, adult hindgut, larval/adult Malpighian tubules, larval/adult salivary gland, adult ovary, larval carcass. Comments on Affy2 ProbeSet: ProbeSet 1638731_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of CG10898. Gene sequence location is 3R:7383451..7385599.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2011_10
FB2012_01	Sequence features BKN20956 HFA14279
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 86E10-86E10   Limits computationally determined from genome sequence between P{PZ}tho1&P{PZ}l(3)0462905275 and P{EP}Lk6EP886
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\CG10898 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) CG10898-RA FBtr0082410  NM_141826   2016   340
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein CG10898-PA   FBpp0081886   37.6   340   6.79     NP_650083   AAF54653
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • NUDIX hydrolase domain (IPR000086) NUDIX hydrolase domain-like (IPR015797) NUDIX hydrolase, conserved site (IPR020084) NUDIX hydrolase (IPR020476)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA949286   AE014297 AAF54653   AI260758   AI260759   AI295676   AW942800   AX094156   AY070551 AAL48022   BF486784   BP553799   CK132230   CO311161   CZ466162   DN154060   EC062394   EC198065   EC205818   EC230960   EC248092
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9VGM4
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0037911    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0037911 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of low expression. Peak expression observed during late pupal stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0037911 expression level Developmental Stage   Expression Level embryo 00-02hr    1284 embryo 02-04hr    462 embryo 04-06hr    727 embryo 06-08hr    673 embryo 08-10hr    541 embryo 10-12hr    916 embryo 12-14hr    1480 embryo 14-16hr    1731 embryo 16-18hr    606 embryo 18-20hr    858 embryo 20-22hr    214 embryo 22-24hr    277 larva L1    427 larva L2    1554 larva L3 12hr old    660 larva L3 puffstage 1-2    812 larva L3 puffstage 3-6    657 larva L3 puffstage 7-9    703 white prepupae new    626 white prepupae 12hr    493 white prepupae 24hr    820 pupae 2d postWPP    4116 pupae 3d postWPP    1212 pupae 4d postWPP    434 adult male 01day    752 adult male 05day    650 adult male 30day    710 adult female 01day    644 adult female 05day    867 adult female 30day    912 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (1284) embryo 02-04hr  (462) embryo 04-06hr  (727) embryo 06-08hr  (673) embryo 08-10hr  (541) embryo 10-12hr  (916) embryo 12-14hr  (1480) embryo 14-16hr  (1731) embryo 16-18hr  (606) embryo 18-20hr  (858) embryo 20-22hr  (214) embryo 22-24hr  (277) larva L1  (427) larva L2  (1554) larva L3 12hr old  (660) larva L3 puffstage 1-2  (812) larva L3 puffstage 3-6  (657) larva L3 puffstage 7-9  (703) white prepupae new  (626) white prepupae 12hr  (493) white prepupae 24hr  (820) pupae 2d postWPP  (4116) pupae 3d postWPP  (1212) pupae 4d postWPP  (434) adult male 01day  (752) adult male 05day  (650) adult male 30day  (710) adult female 01day  (644) adult female 05day  (867) adult female 30day  (912) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    1284 embryo 02-04hr    462 embryo 04-06hr    727 embryo 06-08hr    673 embryo 08-10hr    541 embryo 10-12hr    916 embryo 12-14hr  1480 embryo 14-16hr  (1731) embryo 16-18hr    606 embryo 18-20hr    858 embryo 20-22hr    214 embryo 22-24hr    277 larva L1    427 larva L2  (1554) larva L3 12hr old    660 larva L3 puffstage 1-2    812 larva L3 puffstage 3-6    657 larva L3 puffstage 7-9    703 white prepupae new    626 white prepupae 12hr    493 white prepupae 24hr    820 pupae 2d postWPP  (4116) pupae 3d postWPP    1212 pupae 4d postWPP    434 adult male 01day    752 adult male 05day    650 adult male 30day    710 adult female 01day    644 adult female 05day    867 adult female 30day    912 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    1284 embryo 02-04hr    462 embryo 04-06hr    727 embryo 06-08hr    673 embryo 08-10hr    541 embryo 10-12hr    916 embryo 12-14hr    1480 embryo 14-16hr    1731 embryo 16-18hr    606 embryo 18-20hr    858 embryo 20-22hr    214 embryo 22-24hr    277 larva L1    427 larva L2    1554 larva L3 12hr old    660 larva L3 puffstage 1-2    812 larva L3 puffstage 3-6    657 larva L3 puffstage 7-9    703 white prepupae new    626 white prepupae 12hr    493 white prepupae 24hr    820 pupae 2d postWPP    4116 pupae 3d postWPP    1212 pupae 4d postWPP    434 adult male 01day    752 adult male 05day    650 adult male 30day    710 adult female 01day    644 adult female 05day    867 adult female 30day    912 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    1284 embryo 02-04hr    462 embryo 04-06hr    727 embryo 06-08hr    673 embryo 08-10hr    541 embryo 10-12hr    916 embryo 12-14hr    1480 embryo 14-16hr    1731 embryo 16-18hr    606 embryo 18-20hr    858 embryo 20-22hr    214 embryo 22-24hr    277 larva L1    427 larva L2    1554 larva L3 12hr old    660 larva L3 puffstage 1-2    812 larva L3 puffstage 3-6    657 larva L3 puffstage 7-9    703 white prepupae new    626 white prepupae 12hr    493 white prepupae 24hr    820 pupae 2d postWPP    4116 pupae 3d postWPP    1212 pupae 4d postWPP    434 adult male 01day    752 adult male 05day    650 adult male 30day    710 adult female 01day    644 adult female 05day    867 adult female 30day    912 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0037911 expression level Developmental Stage   Expression Level embryo 00-02hr    1284 embryo 02-04hr    462 embryo 04-06hr    727 embryo 06-08hr    673 embryo 08-10hr    541 embryo 10-12hr    916 embryo 12-14hr    1480 embryo 14-16hr    1731 embryo 16-18hr    606 embryo 18-20hr    858 embryo 20-22hr    214 embryo 22-24hr    277 larva L1    427 larva L2    1554 larva L3 12hr old    660 larva L3 puffstage 1-2    812 larva L3 puffstage 3-6    657 larva L3 puffstage 7-9    703 white prepupae new    626 white prepupae 12hr    493 white prepupae 24hr    820 pupae 2d postWPP    4116 pupae 3d postWPP    1212 pupae 4d postWPP    434 adult male 01day    752 adult male 05day    650 adult male 30day    710 adult female 01day    644 adult female 05day    867 adult female 30day    912 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (1284) embryo 02-04hr  (462) embryo 04-06hr  (727) embryo 06-08hr  (673) embryo 08-10hr  (541) embryo 10-12hr  (916) embryo 12-14hr  (1480) embryo 14-16hr  (1731) embryo 16-18hr  (606) embryo 18-20hr  (858) embryo 20-22hr  (214) embryo 22-24hr  (277) larva L1  (427) larva L2  (1554) larva L3 12hr old  (660) larva L3 puffstage 1-2  (812) larva L3 puffstage 3-6  (657) larva L3 puffstage 7-9  (703) white prepupae new  (626) white prepupae 12hr  (493) white prepupae 24hr  (820) pupae 2d postWPP  (4116) pupae 3d postWPP  (1212) pupae 4d postWPP  (434) adult male 01day  (752) adult male 05day  (650) adult male 30day  (710) adult female 01day  (644) adult female 05day  (867) adult female 30day  (912) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    1284 embryo 02-04hr    462 embryo 04-06hr    727 embryo 06-08hr    673 embryo 08-10hr    541 embryo 10-12hr    916 embryo 12-14hr  1480 embryo 14-16hr  1731 embryo 16-18hr    606 embryo 18-20hr    858 embryo 20-22hr    214 embryo 22-24hr    277 larva L1    427 larva L2  1554 larva L3 12hr old    660 larva L3 puffstage 1-2    812 larva L3 puffstage 3-6    657 larva L3 puffstage 7-9    703 white prepupae new    626 white prepupae 12hr    493 white prepupae 24hr    820 pupae 2d postWPP  (4116) pupae 3d postWPP    1212 pupae 4d postWPP    434 adult male 01day    752 adult male 05day    650 adult male 30day    710 adult female 01day    644 adult female 05day    867 adult female 30day    912 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    1284 embryo 02-04hr    462 embryo 04-06hr    727 embryo 06-08hr    673 embryo 08-10hr    541 embryo 10-12hr    916 embryo 12-14hr    1480 embryo 14-16hr    1731 embryo 16-18hr    606 embryo 18-20hr    858 embryo 20-22hr    214 embryo 22-24hr    277 larva L1    427 larva L2    1554 larva L3 12hr old    660 larva L3 puffstage 1-2    812 larva L3 puffstage 3-6    657 larva L3 puffstage 7-9    703 white prepupae new    626 white prepupae 12hr    493 white prepupae 24hr    820 pupae 2d postWPP    4116 pupae 3d postWPP    1212 pupae 4d postWPP    434 adult male 01day    752 adult male 05day    650 adult male 30day    710 adult female 01day    644 adult female 05day    867 adult female 30day    912 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    1284 embryo 02-04hr    462 embryo 04-06hr    727 embryo 06-08hr    673 embryo 08-10hr    541 embryo 10-12hr    916 embryo 12-14hr    1480 embryo 14-16hr    1731 embryo 16-18hr    606 embryo 18-20hr    858 embryo 20-22hr    214 embryo 22-24hr    277 larva L1    427 larva L2    1554 larva L3 12hr old    660 larva L3 puffstage 1-2    812 larva L3 puffstage 3-6    657 larva L3 puffstage 7-9    703 white prepupae new    626 white prepupae 12hr    493 white prepupae 24hr    820 pupae 2d postWPP    4116 pupae 3d postWPP    1212 pupae 4d postWPP    434 adult male 01day    752 adult male 05day    650 adult male 30day    710 adult female 01day    644 adult female 05day    867 adult female 30day    912 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0037911    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0037911 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: larval trachea. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, adult central nervous system, adult crop, adult hindgut, larval/adult Malpighian tubules, larval/adult salivary gland, adult ovary, larval carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0037911 expression level Tissue   Expression Level Larval Central Nervous System    43.8 Larval Midgut    89.2 Larval Hindgut    92.6 Larval Malpighian Tubules    246.7 Larval Fat Body    60 Larval Salivary Gland    103.8 Larval Trachea    1212.825 Larval Carcass    354.925 Adult Head    104.3 Adult Eye    187.125 Adult Brain    100.5 Adult Thoracic-Abdominal Ganglion    138.7 Adult Crop    161.7 Adult Midgut    72.6 Adult Hindgut    105.4 Adult Malpighian Tubules    288 Adult Fat Body    29.2 Adult Salivary Gland    167.9 Adult Heart    52.7 Adult VirginFemale Spermatheca    70.4 Adult InseminatedFemale Spermatheca    94.8 Adult Ovary    183.8 Adult Testis    83.2 Adult Male Accessory Gland    49.7 Adult Carcass    80.2 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    43.8 Larval Midgut    89.2 Larval Hindgut    92.6 Larval Malpighian Tubules    246.7 Larval Fat Body    60 Larval Salivary Gland    103.8 Larval Trachea  (1212.825) Larval Carcass    354.925 Adult Head    104.3 Adult Eye    187.125 Adult Brain    100.5 Adult Thoracic-Abdominal Ganglion    138.7 Adult Crop    161.7 Adult Midgut    72.6 Adult Hindgut    105.4 Adult Malpighian Tubules    288 Adult Fat Body    29.2 Adult Salivary Gland    167.9 Adult Heart    52.7 Adult VirginFemale Spermatheca    70.4 Adult InseminatedFemale Spermatheca    94.8 Adult Ovary    183.8 Adult Testis    83.2 Adult Male Accessory Gland    49.7 Adult Carcass    80.2 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    43.8 Larval Midgut    89.2 Larval Hindgut    92.6 Larval Malpighian Tubules    246.7 Larval Fat Body    60 Larval Salivary Gland    103.8 Larval Trachea  (1212.825) Larval Carcass    354.925 Adult Head    104.3 Adult Eye    187.125 Adult Brain    100.5 Adult Thoracic-Abdominal Ganglion    138.7 Adult Crop    161.7 Adult Midgut    72.6 Adult Hindgut    105.4 Adult Malpighian Tubules    288 Adult Fat Body    29.2 Adult Salivary Gland    167.9 Adult Heart    52.7 Adult VirginFemale Spermatheca    70.4 Adult InseminatedFemale Spermatheca    94.8 Adult Ovary    183.8 Adult Testis    83.2 Adult Male Accessory Gland    49.7 Adult Carcass    80.2 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    43.8 Larval Midgut    89.2 Larval Hindgut    92.6 Larval Malpighian Tubules    246.7 Larval Fat Body    60 Larval Salivary Gland    103.8 Larval Trachea    1212.825 Larval Carcass    354.925 Adult Head    104.3 Adult Eye    187.125 Adult Brain    100.5 Adult Thoracic-Abdominal Ganglion    138.7 Adult Crop    161.7 Adult Midgut    72.6 Adult Hindgut    105.4 Adult Malpighian Tubules    288 Adult Fat Body    29.2 Adult Salivary Gland    167.9 Adult Heart    52.7 Adult VirginFemale Spermatheca    70.4 Adult InseminatedFemale Spermatheca    94.8 Adult Ovary    183.8 Adult Testis    83.2 Adult Male Accessory Gland    49.7 Adult Carcass    80.2 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0037911 expression level Tissue   Expression Level Larval Central Nervous System    43.8 Larval Midgut    89.2 Larval Hindgut    92.6 Larval Malpighian Tubules    246.7 Larval Fat Body    60 Larval Salivary Gland    103.8 Larval Trachea    1212.825 Larval Carcass    354.925 Adult Head    104.3 Adult Eye    187.125 Adult Brain    100.5 Adult Thoracic-Abdominal Ganglion    138.7 Adult Crop    161.7 Adult Midgut    72.6 Adult Hindgut    105.4 Adult Malpighian Tubules    288 Adult Fat Body    29.2 Adult Salivary Gland    167.9 Adult Heart    52.7 Adult VirginFemale Spermatheca    70.4 Adult InseminatedFemale Spermatheca    94.8 Adult Ovary    183.8 Adult Testis    83.2 Adult Male Accessory Gland    49.7 Adult Carcass    80.2 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    43.8 Larval Midgut    89.2 Larval Hindgut    92.6 Larval Malpighian Tubules    246.7 Larval Fat Body    60 Larval Salivary Gland    103.8 Larval Trachea  (1212.825) Larval Carcass    354.925 Adult Head    104.3 Adult Eye    187.125 Adult Brain    100.5 Adult Thoracic-Abdominal Ganglion    138.7 Adult Crop    161.7 Adult Midgut    72.6 Adult Hindgut    105.4 Adult Malpighian Tubules    288 Adult Fat Body    29.2 Adult Salivary Gland    167.9 Adult Heart    52.7 Adult VirginFemale Spermatheca    70.4 Adult InseminatedFemale Spermatheca    94.8 Adult Ovary    183.8 Adult Testis    83.2 Adult Male Accessory Gland    49.7 Adult Carcass    80.2 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    43.8 Larval Midgut    89.2 Larval Hindgut    92.6 Larval Malpighian Tubules    246.7 Larval Fat Body    60 Larval Salivary Gland    103.8 Larval Trachea  1212.825 Larval Carcass    354.925 Adult Head    104.3 Adult Eye    187.125 Adult Brain    100.5 Adult Thoracic-Abdominal Ganglion    138.7 Adult Crop    161.7 Adult Midgut    72.6 Adult Hindgut    105.4 Adult Malpighian Tubules    288 Adult Fat Body    29.2 Adult Salivary Gland    167.9 Adult Heart    52.7 Adult VirginFemale Spermatheca    70.4 Adult InseminatedFemale Spermatheca    94.8 Adult Ovary    183.8 Adult Testis    83.2 Adult Male Accessory Gland    49.7 Adult Carcass    80.2 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    43.8 Larval Midgut    89.2 Larval Hindgut    92.6 Larval Malpighian Tubules    246.7 Larval Fat Body    60 Larval Salivary Gland    103.8 Larval Trachea    1212.825 Larval Carcass    354.925 Adult Head    104.3 Adult Eye    187.125 Adult Brain    100.5 Adult Thoracic-Abdominal Ganglion    138.7 Adult Crop    161.7 Adult Midgut    72.6 Adult Hindgut    105.4 Adult Malpighian Tubules    288 Adult Fat Body    29.2 Adult Salivary Gland    167.9 Adult Heart    52.7 Adult VirginFemale Spermatheca    70.4 Adult InseminatedFemale Spermatheca    94.8 Adult Ovary    183.8 Adult Testis    83.2 Adult Male Accessory Gland    49.7 Adult Carcass    80.2 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    104.3   NA  Eye    187.125   NA  Brain    100.5   43.8  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    138.7   NA  Crop    161.7   89.2  Midgut    72.6   92.6  Hindgut    105.4   246.7  Malpighian Tubules    288   60  Fat Body    29.2   103.8  Salivary Gland    167.9   NA  Heart    52.7   1212.825  Trachea    NA   NA  VirginFemale Spermatheca    70.4   NA  InseminatedFemale Spermatheca    94.8   NA  Ovary    183.8   NA  Testis    83.2   NA  Male Accessory Gland    49.7   354.925  Carcass    80.2 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_09
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0037911 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG10898-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable CG10898c05103 viable, with Scer\GAL4pnr-MD237 CG10898GD4230 Sterility Allele fertile CG10898c05103 Phenotype manifest in Allele
Classical Alleles ( 5 )
For All Classical Alleles Show
Allele of CG10898 Class Mutagen Stocks Known lesion CG10898c05103 piggyBac transposase 2 -- CG10898c00045 piggyBac transposase 1 -- CG10898d01462 1 -- CG10898EY20591 P-element activity 1 -- CG10898HP30577 1 --
Alleles Carried on Transgenic Constructs ( 2 )
For All Alleles Carried on Transgenic Constructs Show
Allele of CG10898 Class Mutagen Stocks Known lesion CG10898GD4230 in vitro construct - RNAi in vitro construct - regulatory fusion 3 Yes CG10898KK100860 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes
Aneuploid Aberrations
Disrupted in	Df(3R)Exel6160 (Ryder, 2004.4.26) Df(3R)Exel8153 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD4230} NA P{KK100860} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions PBac{PB}CG10898c00045 NA PBac{PB}CG10898c05103 NA insertion of mobile activating element P{EPg}CG10898HP30577 NA P{EPgy2}CG10898EY20591 NA P{XP}CG10898d01462 NA
Gene Ontology: Function, Process & Cellular Component ( 2 unique terms )
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 2 terms )
Molecular Function
CV term Evidence References
hydrolase activity inferred from electronic annotation with InterPro:IPR000086, InterPro:IPR015797, InterPro:IPR020084 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
DNA repair inferred from sequence or structural similarity (Burtis, 1999.11)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions CG10898 allele Gene References
External Data
Linkouts	DPiM - DPiM, Drosophila Protein interaction Map • FBgn0037911 DroID - A comprehensive database of gene and protein interactions. • FBgn0037911 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 41384
Orthologs
Genome-wide drosophilid orthologs	Dana\GF18377 Dere\GG18222 Dgri\GH17327 Dmoj\GI10291 Dper\GL12379 Dpse\GA10624 Dsec\GM23952 Dsim\GD18763 Dvir\GJ11098 Dwil\GK11300 Dyak\GE24179
Curated drosophilid orthologs	Dpse\GA10624
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL007364-PA Aedes aegypti (mosquito) AGAP002403-PA Anopheles gambiae (mosquito) XP_397372.3 Apis mellifera (honey bee) XP_001951360.1 Acyrthosiphon pisum (pea aphid) 86473 Branchiostoma floridae (lancelet) BGIBMGA011509-PA Bombyx mori (silk worm) ENSBTAP00000004527 Bos taurus (bovine) CN18298 Caenorhabditis brenneri (small nematode) CN28923 Caenorhabditis brenneri (small nematode) CBP28171 Caenorhabditis briggsae (nematode) CE14186 Caenorhabditis elegans (worm) ENSCAFP00000014215 Canis familiaris (dog) JA00234 Caenorhabditis japonica (nematode) CPIJ007497 Culex pipens (mosquito) ENSCPOP00000001522 Cavia porcellus (guinea pig) RP49005 Caenorhabditis remanei (nematode) 64248 Capitella spl (polychaete worm) 202142 Daphnia pulex (daphnia) ENSDARP00000060954 Danio rerio (zebra fish) ENSECAP00000008519 Equus caballus (horse) 159814 Hypsipyla robusta (cedar shoot borer) ISCW015557-PA Ixodes scapularis (deer tick) 232724 Lottia gigantea (owl limpet) ENSMODP00000012017 Monodelphis domestica (gray opossum) ENSMMUP00000017093 Macaca mulatta (rhesus monkey) ENSMUSP00000086450 Mus musculus (house mouse) 214206 Nematostella vectensis (starlet anemone) ENSOANP00000011363 Ornithorynchus anatinus (platypus) PHUM005505-PA Pediculus humanus (human body louse) ENSRNOP00000015969 Rattus norvegicus (norway rat) XP_966613.1 Tribolium castaneum (red flour beetle) ENSTRUP00000030374 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000023110 Xenopus tropicalis (frog) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV10353 LH16161 ISCW015557 FBgn0241310 FBgn0213311 FBgn0198359 FBgn0190283 FBgn0178817 JGI_V11_202142 FBgn0070680 FBgn0149986 FBgn0133056 FBgn0124797 FBgn0110438 FBgn0095395 CPIJ007497 BGIBMGA011509 ACYPI005693 GB15950 AGAP002403 AAEL007364 PB20011 PHUM430950 GLEAN_04374
Stocks & Reagents
Stocks Listed in FlyBase ( 10 )
Bloomington	21954 w1118; P{EPg}CG10898HP30577 17692 w1118; PBac{PB}CG10898c05103 22401 y1 w67c23; P{EPgy2}CG10898EY20591/TM3, Sb1 Ser1
Harvard	- P{XP}CG10898d01462 - PBac{PB}CG10898c00045 - PBac{PB}CG10898c05103
VDRC	v103422 P{KK100860}VIE-260B v13643 w1118; P{GD4230}v13643 v14910 w1118; P{GD4230}v14910/TM3 v39696 w1118; P{GD4230}v39696/CyO
Genomic Clones ( 1 )
	BACR24C01 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 15 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD28119
Other clones	DPiM_LD28119
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT21312 LP04726 LP04727 LP09369 LP13590
Other clones	11495 53071 101090 CK01.2B.E11 CK01.100A.C10 EK170053 EK223634 FGM226D02
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0037911 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 41384
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: CG10898 anon-WO0118547.280 (FlyBase, 1996-)
Additional comments	Source for merge of CG10898 anon-WO0118547.280 was sequence comparison (date:051113). (FlyBase, 1996-)
Other Comments
	Area matching Drosophila EST AI260759 (inverted). (Davies, 2001.3.15)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_141826 RefSeq (Proteins) • NP_650083 DDBJ / EMBL / GenBank • AA949286 AAF54653 AAL48022 AI260759 AW942800 AX094156 AY070551 CZ466162 Entrez Gene - A searchable database of RefSeq genes. • 41384 UniProtKB/TrEMBL • Q9VGM4
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • NUDIX hydrolase domain (IPR000086) NUDIX hydrolase domain-like (IPR015797) NUDIX hydrolase, conserved site (IPR020084) NUDIX hydrolase (IPR020476)
Linkouts
	DPiM - DPiM, Drosophila Protein interaction Map • FBgn0037911 DroID - A comprehensive database of gene and protein interactions. • FBgn0037911 DRSC - Results from RNAi screens. • FBgn0037911 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0037911 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG10898-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0037911 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 41384 InParanoid A subset of ortholog calls from InParanoid. • AAEL007364-PA Aedes aegypti (mosquito) AGAP002403-PA Anopheles gambiae (mosquito) XP_397372.3 Apis mellifera (honey bee) XP_001951360.1 Acyrthosiphon pisum (pea aphid) 86473 Branchiostoma floridae (lancelet) BGIBMGA011509-PA Bombyx mori (silk worm) ENSBTAP00000004527 Bos taurus (bovine) CN18298 Caenorhabditis brenneri (small nematode) CN28923 Caenorhabditis brenneri (small nematode) CBP28171 Caenorhabditis briggsae (nematode) CE14186 Caenorhabditis elegans (worm) ENSCAFP00000014215 Canis familiaris (dog) JA00234 Caenorhabditis japonica (nematode) CPIJ007497 Culex pipens (mosquito) ENSCPOP00000001522 Cavia porcellus (guinea pig) RP49005 Caenorhabditis remanei (nematode) 64248 Capitella spl (polychaete worm) 202142 Daphnia pulex (daphnia) ENSDARP00000060954 Danio rerio (zebra fish) ENSECAP00000008519 Equus caballus (horse) 159814 Hypsipyla robusta (cedar shoot borer) ISCW015557-PA Ixodes scapularis (deer tick) 232724 Lottia gigantea (owl limpet) ENSMODP00000012017 Monodelphis domestica (gray opossum) ENSMMUP00000017093 Macaca mulatta (rhesus monkey) ENSMUSP00000086450 Mus musculus (house mouse) 214206 Nematostella vectensis (starlet anemone) ENSOANP00000011363 Ornithorynchus anatinus (platypus) PHUM005505-PA Pediculus humanus (human body louse) ENSRNOP00000015969 Rattus norvegicus (norway rat) XP_966613.1 Tribolium castaneum (red flour beetle) ENSTRUP00000030374 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000023110 Xenopus tropicalis (frog) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 41384 modMine - Data generated by the modENCODE project. • FBgn0037911 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV10353 LH16161 ISCW015557 FBgn0241310 FBgn0213311 FBgn0198359 FBgn0190283 FBgn0178817 JGI_V11_202142 FBgn0070680 FBgn0149986 FBgn0133056 FBgn0124797 FBgn0110438 FBgn0095395 CPIJ007497 BGIBMGA011509 ACYPI005693 GB15950 AGAP002403 AAEL007364 PB20011 PHUM430950 GLEAN_04374
Synonyms & Secondary IDs ( 2 )
Reported As
Symbol Synonym	anon-WO0118547.280   CG10898 (Lebo et al., 2009, Keleman et al., 2009.8.5)
Name Synonym
Secondary FlyBase IDs
	FBgn0062122
References ( 20 )
Research paper	Lebo et al., 2009, BMC Genomics 10: 80 Somatic, germline and sex hierarchy regulated gene expression during Drosophila metamorphosis. [FBrf0207472] Egger et al., 2002, Development 129(14): 3295--3309 Gliogenesis in Drosophila: genome-wide analysis of downstream genes of glial cells missing in the embryonic nervous system. [FBrf0151258]
Supplementary material	The modENCODE Consortium, 2010, Science 330(6012): DataS14: Gene co-expression clusters. [FBrf0213979] Mummery-Widmer et al., 2009, Nature 458(7241): Supplementary Table 2 - Genome-wide bristle screen results. [FBrf0214518]
Personal communication to FlyBase	Keleman et al., 2009.8.5, RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0208510] Levis, 2009.8.13, Release 5 sequence localizations for HP and DP lines. Release 5 sequence localizations for HP and DP lines. [FBrf0208533] Dickson et al., 2007.7.18, RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0200327] Bellen, 2006.8.3, MBBatch686_2.xml MBBatch686_2.xml [FBrf0191805] Bloomington Drosophila Stock Center, 2004.11.6, Exelixis insertion alleles that are not in FlyBase. Exelixis insertion alleles that are not in FlyBase. [FBrf0179797] FlyBase Curators et al., 2004-, Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. [FBrf0174215] Ryder, 2004.4.26, Exelixis CG deletion data. Exelixis CG deletion data. [FBrf0184335]
FlyBase analysis	FlyBase Curators, 2008, Insertion identifiers and alleles based on genomic location of insertions with respect to gene annotations. Insertion identifiers and alleles based on genomic location of insertions with respect to gene annotations. [FBrf0202955] FlyBase, 1996-, FlyBase inference based on genome sequence analysis. FlyBase inference based on genome sequence analysis. [FBrf0104946] FlyBase, 1992-, FlyBase curation FlyBase curation. [FBrf0105495]
Patent	Davies et al., 2001, World Patent 0118547: Essential genes and assays relating thereto. [FBrf0199103]
DNA/RNA sequence record	Davies, 2001.3.15, GenBank/EMBL/DDBJ: AX094156 Sequence 280 from Patent WO0118547. [FBrf0149980]
Curated genome annotation	Burtis, 1999.11, [Annotations performed at the Celera Jamboreee.] [Annotations performed at the Celera Jamboreee.] [FBrf0126655]
Computer file	Gene Disruption Project members and Exelixis, 2005, Genomic mapping of Exelixis insertion collection. Genomic mapping of Exelixis insertion collection. [FBrf0184340] Gene Disruption Project members, 2001-, [title not yet available] [title not yet available] [FBrf0132177] BDGP Project Members, 2000-, Berkeley Drosophila Genome Project. Berkeley Drosophila Genome Project. [FBrf0125078]