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Gene Dmel\sea

General Information
Symbol	Dmel\sea	Species	D. melanogaster
Name	scheggia	Annotation symbol	CG6782
Feature type	protein_coding_gene	FlyBase ID	FBgn0037912
Gene Model Status	Current	Stock availability	7 publicly available
Also Known As	CG31305, DmCIC
Genomic Location
Chromosome (arm)	3R	Recombination map
Cytogenetic map	86E10-86E10	Sequence location	3R:7,385,612..7,392,771 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene scheggia is referred to in FlyBase by the symbol Dmel\sea (CG6782, FBgn0037912). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: transmembrane transporter activity; tricarboxylate secondary active transmembrane transporter activity. There is experimental evidence that it is involved in the biological process: citrate transport; mitochondrial citrate transport. 16 alleles are reported. The phenotypes of these alleles are annotated with: condensed chromosome; embryonic/larval neuroblast. It has 4 annotated transcripts and 4 annotated polypeptides. Protein features are: Mitochondrial carrier domain; Mitochondrial substrate/solute carrier. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderate expression. Peak expression observed within 00-06 and 12-24 hour embryonic stages, at stages throughout the larval period, at stages throughout the pupal period, in stages of adults of both sexes. This gene is annotated by FlyBase as a dicistronic gene, meaning that some or all of its transcripts encode two or more polypeptide-coding open reading frames (ORFs) , with each ORF assigned to a different gene. The distribution of RNA-Seq coverage data amongst the different encoded genes cannot be determined. Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, adult thoracico-abdominal ganglion, adult crop, larval/adult midgut, larval/adult hindgut, adult Malpighian tubules, adult heart, adult fat body, adult salivary gland, larval trachea, adult female reproductive system, larval/adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: larval/adult central nervous system, larval Malpighian tubules, larval fat body, larval salivary gland, adult male reproductive system. Comments on Affy2 ProbeSet: ProbeSet 1623518_s_at aligns to a genomic region shared by exons of 2 FlyBase-annotated genes; hence it is impossible to interpret the expression pattern and levels of sea expression signal. See the GBrowse view of sea to determine the overlapping gene(s). Gene sequence location is 3R:7385612..7392771.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 86E10-86E10   Limits computationally determined from genome sequence between P{PZ}tho1&P{PZ}l(3)0462905275 and P{EP}Lk6EP886
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\sea for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	gene_with_dicistronic_mRNA ; SO:0000722
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) sea-RA FBtr0100461  NM_001032007   1314   317 sea-RC FBtr0100462  NM_001032006   1352   317 sea-RD FBtr0100464  NM_001032005   1661   317 sea-RE FBtr0100465  NM_001032004   1447   317
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein sea-PA   FBpp0099888   34.1   317   9.91     NP_001027178   AAN13508 sea-PC   FBpp0099889   34.1   317   9.91     NP_001027177   AAN13509 sea-PD   FBpp0099890   34.1   317   9.91     NP_001027176   AAF54654 sea-PE   FBpp0099892   34.1   317   9.91     NP_001027175   AAN13510
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Mitochondrial substrate/solute carrier (IPR018108) Mitochondrial carrier domain (IPR023395) MitoDrome - A database of annotated Dmel nuclear genes encoding mitochondrial proteins • MTDROME31305
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA140693   AA140694   AA803257   AA803449   AA804078   AA978681   AE014297 AAF54654   AE014297 AAN13508   AE014297 AAN13509   AE014297 AAN13510   AI063973   AI064631   AI108239   AI239104   AI294952   AI387236   AI389649   AI389687   AI389751   AI402446   AI402825   AI514635   AQ073857   AQ073947   AQ074008   AX154663   AY060229   AY061503 AAL29051   BF490431   BG641333   BI167715   BI172906   BI216019   BI228018   BI229065   BI234229   BI235173   BI236051   BI238546   BI241378   BI241456   BI242778   BI357460   BI361318   BI364285   BI365869   BI366521   BI367872   BI368408   BI368883   BI369383   BI370262   BI370315   BI371488   BI375983   BI482704   BI483503   BI567477   BI568235   BI569075   BI569076   BI569556   BI570156   BI570193   BI573538   BI574768   BI575726   BI577498   BI579130   BI582694   BI583822   BI585638   BI587043   BI588184   BI588891   BI604840   BI605675   BI610267   BI611821   BI616440   BI616636   BI617974   BI618501   BI620038   BI620635   BI625014   BI625740   BI627179   BI628465   BI629242   BI633806   BI636946   BI639721   BP544594   BP544595   BP551603   BP551604   BP553912   BP559772   BP559773   BQ102904   BQ103028   BT001798 AAN71553   BX053548   CC060158   CO180835   CO184710   CO188218   CO190805   CO263479   CO264704   CO298939   CO316914   CO322168   CO324512   CO327113   CO341762   EC064170   EC066569   EC078265   EC083003   EC194995   EC198545   EC208287   EC209165   EC223797   EC246442   EC251475   EC251910   EC262727   EV582002   EV592493   EV595614   FD586329   FD586372   FD587030   FD587527   GH740203   GH741356   GH742007   GH746622   GH757457   GH759968   GH762995   GH767131   GH768942   GH803934   GH804066   GH807915   GH820286   GH821466   GH827401   GH837019   GH859215   GH868570   GH873873   GH885867   GH899143   GH907997   GH917643   GH921934   GH922810   GH923339   GH941769   GH943109   GH943162   GH943336   GH944610   GH944625   GH945329   GH945412   GH945744   GH947532   GH947575   GH947973   GH949235   GH949371   GH950326   GH950421   GH950504   GH950506   GH951493   GH953328   GH953368   GH954657   GH959590   GH961119   GH961607   GH963023   GH963181   GH963252   GH963462   GH963495   GH963898   GH964287   GH964496   GH965480   GH965974   GH966920   GH967115   GH967506   GH968523   GH969587   GH970123   GH971866   GH972143   GH972846   GH973092   GH974665   GH975671   GH976543   GH978567   GH980129   GH982992   GH983348   GH983655   GO254501
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q7KSQ0
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 7 of adulthood -- day 49 of adulthood   adult heart   (Cammarato et al., 2011)
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
lipid particle inferred from direct assay (Beller et al., 2006) mitochondrion inferred from direct assay (Morciano et al., 2009) Nebenkern inferred from direct assay (Morciano et al., 2009)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, adult thoracico-abdominal ganglion, adult crop, larval/adult midgut, larval/adult hindgut, adult Malpighian tubules, adult heart, adult fat body, adult salivary gland, larval trachea, adult female reproductive system, larval/adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: larval/adult central nervous system, larval Malpighian tubules, larval fat body, larval salivary gland, adult male reproductive system. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    432.725 Larval Midgut    1421.1 Larval Hindgut    961.6 Larval Malpighian Tubules    130.5 Larval Fat Body    401.3 Larval Salivary Gland    412.5 Larval Trachea    932.25 Larval Carcass    869.6 Adult Head    913.9 Adult Eye    954.225 Adult Brain    495 Adult Thoracic-Abdominal Ganglion    584.4 Adult Crop    1108.9 Adult Midgut    1714.3 Adult Hindgut    1208.8 Adult Malpighian Tubules    617 Adult Fat Body    2481.3 Adult Salivary Gland    1637.4 Adult Heart    2103.375 Adult VirginFemale Spermatheca    3431.9 Adult InseminatedFemale Spermatheca    3479 Adult Ovary    502.6 Adult Testis    195.9 Adult Male Accessory Gland    188.2 Adult Carcass    1772.4 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    432.725 Larval Midgut  (1421.1) Larval Hindgut  (961.6) Larval Malpighian Tubules    130.5 Larval Fat Body    401.3 Larval Salivary Gland    412.5 Larval Trachea  (932.25) Larval Carcass  (869.6) Adult Head  (913.9) Adult Eye  (954.225) Adult Brain    495 Adult Thoracic-Abdominal Ganglion  (584.4) Adult Crop  (1108.9) Adult Midgut  (1714.3) Adult Hindgut  (1208.8) Adult Malpighian Tubules  (617) Adult Fat Body  (2481.3) Adult Salivary Gland  (1637.4) Adult Heart  (2103.375) Adult VirginFemale Spermatheca  (3431.9) Adult InseminatedFemale Spermatheca  (3479) Adult Ovary  502.6 Adult Testis    195.9 Adult Male Accessory Gland    188.2 Adult Carcass  (1772.4) Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    432.725 Larval Midgut  (1421.1) Larval Hindgut    961.6 Larval Malpighian Tubules    130.5 Larval Fat Body    401.3 Larval Salivary Gland    412.5 Larval Trachea    932.25 Larval Carcass    869.6 Adult Head    913.9 Adult Eye    954.225 Adult Brain    495 Adult Thoracic-Abdominal Ganglion    584.4 Adult Crop  (1108.9) Adult Midgut  (1714.3) Adult Hindgut  (1208.8) Adult Malpighian Tubules    617 Adult Fat Body  (2481.3) Adult Salivary Gland  (1637.4) Adult Heart  (2103.375) Adult VirginFemale Spermatheca  (3431.9) Adult InseminatedFemale Spermatheca  (3479) Adult Ovary    502.6 Adult Testis    195.9 Adult Male Accessory Gland    188.2 Adult Carcass  (1772.4) Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    432.725 Larval Midgut    1421.1 Larval Hindgut    961.6 Larval Malpighian Tubules    130.5 Larval Fat Body    401.3 Larval Salivary Gland    412.5 Larval Trachea    932.25 Larval Carcass    869.6 Adult Head    913.9 Adult Eye    954.225 Adult Brain    495 Adult Thoracic-Abdominal Ganglion    584.4 Adult Crop    1108.9 Adult Midgut    1714.3 Adult Hindgut    1208.8 Adult Malpighian Tubules    617 Adult Fat Body    2481.3 Adult Salivary Gland    1637.4 Adult Heart    2103.375 Adult VirginFemale Spermatheca    3431.9 Adult InseminatedFemale Spermatheca    3479 Adult Ovary    502.6 Adult Testis    195.9 Adult Male Accessory Gland    188.2 Adult Carcass    1772.4 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    432.725 Larval Midgut    1421.1 Larval Hindgut    961.6 Larval Malpighian Tubules    130.5 Larval Fat Body    401.3 Larval Salivary Gland    412.5 Larval Trachea    932.25 Larval Carcass    869.6 Adult Head    913.9 Adult Eye    954.225 Adult Brain    495 Adult Thoracic-Abdominal Ganglion    584.4 Adult Crop    1108.9 Adult Midgut    1714.3 Adult Hindgut    1208.8 Adult Malpighian Tubules    617 Adult Fat Body    2481.3 Adult Salivary Gland    1637.4 Adult Heart    2103.375 Adult VirginFemale Spermatheca    3431.9 Adult InseminatedFemale Spermatheca    3479 Adult Ovary    502.6 Adult Testis    195.9 Adult Male Accessory Gland    188.2 Adult Carcass    1772.4 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    432.725 Larval Midgut  (1421.1) Larval Hindgut  (961.6) Larval Malpighian Tubules    130.5 Larval Fat Body    401.3 Larval Salivary Gland    412.5 Larval Trachea  (932.25) Larval Carcass  (869.6) Adult Head  (913.9) Adult Eye  (954.225) Adult Brain    495 Adult Thoracic-Abdominal Ganglion  584.4 Adult Crop  (1108.9) Adult Midgut  (1714.3) Adult Hindgut  (1208.8) Adult Malpighian Tubules  617 Adult Fat Body  (2481.3) Adult Salivary Gland  (1637.4) Adult Heart  (2103.375) Adult VirginFemale Spermatheca  (3431.9) Adult InseminatedFemale Spermatheca  (3479) Adult Ovary  502.6 Adult Testis    195.9 Adult Male Accessory Gland    188.2 Adult Carcass  (1772.4) Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    432.725 Larval Midgut  1421.1 Larval Hindgut    961.6 Larval Malpighian Tubules    130.5 Larval Fat Body    401.3 Larval Salivary Gland    412.5 Larval Trachea    932.25 Larval Carcass    869.6 Adult Head    913.9 Adult Eye    954.225 Adult Brain    495 Adult Thoracic-Abdominal Ganglion    584.4 Adult Crop  1108.9 Adult Midgut  1714.3 Adult Hindgut  1208.8 Adult Malpighian Tubules    617 Adult Fat Body  (2481.3) Adult Salivary Gland  1637.4 Adult Heart  (2103.375) Adult VirginFemale Spermatheca  (3431.9) Adult InseminatedFemale Spermatheca  (3479) Adult Ovary    502.6 Adult Testis    195.9 Adult Male Accessory Gland    188.2 Adult Carcass  (1772.4) Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    432.725 Larval Midgut    1421.1 Larval Hindgut    961.6 Larval Malpighian Tubules    130.5 Larval Fat Body    401.3 Larval Salivary Gland    412.5 Larval Trachea    932.25 Larval Carcass    869.6 Adult Head    913.9 Adult Eye    954.225 Adult Brain    495 Adult Thoracic-Abdominal Ganglion    584.4 Adult Crop    1108.9 Adult Midgut    1714.3 Adult Hindgut    1208.8 Adult Malpighian Tubules    617 Adult Fat Body    2481.3 Adult Salivary Gland    1637.4 Adult Heart    2103.375 Adult VirginFemale Spermatheca    3431.9 Adult InseminatedFemale Spermatheca    3479 Adult Ovary    502.6 Adult Testis    195.9 Adult Male Accessory Gland    188.2 Adult Carcass    1772.4 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    913.9   NA  Eye    954.225   NA  Brain    495   432.725  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    584.4   NA  Crop    1108.9   1421.1  Midgut    1714.3   961.6  Hindgut    1208.8   130.5  Malpighian Tubules    617   401.3  Fat Body    2481.3   412.5  Salivary Gland    1637.4   NA  Heart    2103.375   932.25  Trachea    NA   NA  VirginFemale Spermatheca    3431.9   NA  InseminatedFemale Spermatheca    3479   NA  Ovary    502.6   NA  Testis    195.9   NA  Male Accessory Gland    188.2   869.6  Carcass    1772.4 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    205 central nervous system, larvae L3    853 central nervous system, pupae P8    128 head, virgin 1-day female    546 head, virgin 4-day female    252 head, virgin 20-day female    201 head, mated 1-day female    323 head, mated 4-day female    180 head, mated 20-day female    175 head, mated 1-day male    499 head, mated 4-day male    276 head, mated 20-day male    291 salivary gland, larvae L3 wandering    40 salivary gland, white prepupae    51 digestive system, larvae L3 wandering    301 digestive system, 1-day adult    578 digestive system, 4-day adult    380 digestive system, 20-day adult    351 fat body, larvae L3 wandering    796 fat body, white prepupae    157 fat body, pupae P8    491 carcass, larvae L3 wandering    217 carcass, 1-day adult    206 carcass, 4-day adult    190 carcass, 20-day adult    208 ovary, virgin 4-day female    330 ovary, mated 4-day female    290 testis, mated 4-day male    219 accessory gland, mated 4-day male    75 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (205) central nervous system, larvae L3  (853) central nervous system, pupae P8  (128) head, virgin 1-day female  (546) head, virgin 4-day female  (252) head, virgin 20-day female  (201) head, mated 1-day female  (323) head, mated 4-day female  (180) head, mated 20-day female  (175) head, mated 1-day male  (499) head, mated 4-day male  (276) head, mated 20-day male  (291) salivary gland, larvae L3 wandering  (40) salivary gland, white prepupae  (51) digestive system, larvae L3 wandering  (301) digestive system, 1-day adult  (578) digestive system, 4-day adult  (380) digestive system, 20-day adult  (351) fat body, larvae L3 wandering  (796) fat body, white prepupae  (157) fat body, pupae P8  (491) carcass, larvae L3 wandering  (217) carcass, 1-day adult  (206) carcass, 4-day adult  (190) carcass, 20-day adult  (208) ovary, virgin 4-day female  (330) ovary, mated 4-day female  (290) testis, mated 4-day male  (219) accessory gland, mated 4-day male  (75) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (205) central nervous system, larvae L3  (853) central nervous system, pupae P8  (128) head, virgin 1-day female  (546) head, virgin 4-day female  (252) head, virgin 20-day female  (201) head, mated 1-day female  (323) head, mated 4-day female  (180) head, mated 20-day female  (175) head, mated 1-day male  (499) head, mated 4-day male  (276) head, mated 20-day male  (291) salivary gland, larvae L3 wandering    40 salivary gland, white prepupae    51 digestive system, larvae L3 wandering  (301) digestive system, 1-day adult  (578) digestive system, 4-day adult  (380) digestive system, 20-day adult  (351) fat body, larvae L3 wandering  (796) fat body, white prepupae  (157) fat body, pupae P8  (491) carcass, larvae L3 wandering  (217) carcass, 1-day adult  (206) carcass, 4-day adult  (190) carcass, 20-day adult  (208) ovary, virgin 4-day female  (330) ovary, mated 4-day female  (290) testis, mated 4-day male  (219) accessory gland, mated 4-day male    75 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    205 central nervous system, larvae L3    853 central nervous system, pupae P8    128 head, virgin 1-day female    546 head, virgin 4-day female    252 head, virgin 20-day female    201 head, mated 1-day female    323 head, mated 4-day female    180 head, mated 20-day female    175 head, mated 1-day male    499 head, mated 4-day male    276 head, mated 20-day male    291 salivary gland, larvae L3 wandering    40 salivary gland, white prepupae    51 digestive system, larvae L3 wandering    301 digestive system, 1-day adult    578 digestive system, 4-day adult    380 digestive system, 20-day adult    351 fat body, larvae L3 wandering    796 fat body, white prepupae    157 fat body, pupae P8    491 carcass, larvae L3 wandering    217 carcass, 1-day adult    206 carcass, 4-day adult    190 carcass, 20-day adult    208 ovary, virgin 4-day female    330 ovary, mated 4-day female    290 testis, mated 4-day male    219 accessory gland, mated 4-day male    75 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    205 central nervous system, larvae L3    853 central nervous system, pupae P8    128 head, virgin 1-day female    546 head, virgin 4-day female    252 head, virgin 20-day female    201 head, mated 1-day female    323 head, mated 4-day female    180 head, mated 20-day female    175 head, mated 1-day male    499 head, mated 4-day male    276 head, mated 20-day male    291 salivary gland, larvae L3 wandering    40 salivary gland, white prepupae    51 digestive system, larvae L3 wandering    301 digestive system, 1-day adult    578 digestive system, 4-day adult    380 digestive system, 20-day adult    351 fat body, larvae L3 wandering    796 fat body, white prepupae    157 fat body, pupae P8    491 carcass, larvae L3 wandering    217 carcass, 1-day adult    206 carcass, 4-day adult    190 carcass, 20-day adult    208 ovary, virgin 4-day female    330 ovary, mated 4-day female    290 testis, mated 4-day male    219 accessory gland, mated 4-day male    75 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (205) central nervous system, larvae L3  (853) central nervous system, pupae P8  (128) head, virgin 1-day female  (546) head, virgin 4-day female  (252) head, virgin 20-day female  (201) head, mated 1-day female  (323) head, mated 4-day female  (180) head, mated 20-day female  (175) head, mated 1-day male  (499) head, mated 4-day male  (276) head, mated 20-day male  (291) salivary gland, larvae L3 wandering  (40) salivary gland, white prepupae  (51) digestive system, larvae L3 wandering  (301) digestive system, 1-day adult  (578) digestive system, 4-day adult  (380) digestive system, 20-day adult  (351) fat body, larvae L3 wandering  (796) fat body, white prepupae  (157) fat body, pupae P8  (491) carcass, larvae L3 wandering  (217) carcass, 1-day adult  (206) carcass, 4-day adult  (190) carcass, 20-day adult  (208) ovary, virgin 4-day female  (330) ovary, mated 4-day female  (290) testis, mated 4-day male  (219) accessory gland, mated 4-day male  (75) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (205) central nervous system, larvae L3  (853) central nervous system, pupae P8  128 head, virgin 1-day female  (546) head, virgin 4-day female  (252) head, virgin 20-day female  (201) head, mated 1-day female  (323) head, mated 4-day female  (180) head, mated 20-day female  (175) head, mated 1-day male  (499) head, mated 4-day male  (276) head, mated 20-day male  (291) salivary gland, larvae L3 wandering    40 salivary gland, white prepupae    51 digestive system, larvae L3 wandering  (301) digestive system, 1-day adult  (578) digestive system, 4-day adult  (380) digestive system, 20-day adult  (351) fat body, larvae L3 wandering  (796) fat body, white prepupae  (157) fat body, pupae P8  (491) carcass, larvae L3 wandering  (217) carcass, 1-day adult  (206) carcass, 4-day adult  (190) carcass, 20-day adult  (208) ovary, virgin 4-day female  (330) ovary, mated 4-day female  (290) testis, mated 4-day male  (219) accessory gland, mated 4-day male    75 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    205 central nervous system, larvae L3    853 central nervous system, pupae P8    128 head, virgin 1-day female    546 head, virgin 4-day female    252 head, virgin 20-day female    201 head, mated 1-day female    323 head, mated 4-day female    180 head, mated 20-day female    175 head, mated 1-day male    499 head, mated 4-day male    276 head, mated 20-day male    291 salivary gland, larvae L3 wandering    40 salivary gland, white prepupae    51 digestive system, larvae L3 wandering    301 digestive system, 1-day adult    578 digestive system, 4-day adult    380 digestive system, 20-day adult    351 fat body, larvae L3 wandering    796 fat body, white prepupae    157 fat body, pupae P8    491 carcass, larvae L3 wandering    217 carcass, 1-day adult    206 carcass, 4-day adult    190 carcass, 20-day adult    208 ovary, virgin 4-day female    330 ovary, mated 4-day female    290 testis, mated 4-day male    219 accessory gland, mated 4-day male    75 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderate expression. Peak expression observed within 00-06 and 12-24 hour embryonic stages, at stages throughout the larval period, at stages throughout the pupal period, in stages of adults of both sexes. This gene is annotated by FlyBase as a dicistronic gene, meaning that some or all of its transcripts encode two or more polypeptide-coding open reading frames (ORFs) , with each ORF assigned to a different gene. The distribution of RNA-Seq coverage data amongst the different encoded genes cannot be determined. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    202 embryo 02-04hr    33 embryo 04-06hr    18 embryo 06-08hr    21 embryo 08-10hr    38 embryo 10-12hr    87 embryo 12-14hr    69 embryo 14-16hr    154 embryo 16-18hr    176 embryo 18-20hr    159 embryo 20-22hr    139 embryo 22-24hr    161 larva L1    209 larva L2    318 larva L3 12hr old    405 larva L3 puffstage 1-2    534 larva L3 puffstage 3-6    319 larva L3 puffstage 7-9    219 white prepupae new    196 white prepupae 12hr    338 white prepupae 24hr    254 pupae 2d postWPP    151 pupae 3d postWPP    100 pupae 4d postWPP    232 adult male 01day    265 adult male 05day    219 adult male 30day    212 adult female 01day    396 adult female 05day    307 adult female 30day    318 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (202) embryo 02-04hr  (33) embryo 04-06hr    18 embryo 06-08hr    21 embryo 08-10hr  (38) embryo 10-12hr  (87) embryo 12-14hr  (69) embryo 14-16hr  (154) embryo 16-18hr  (176) embryo 18-20hr  (159) embryo 20-22hr  (139) embryo 22-24hr  (161) larva L1  (209) larva L2  (318) larva L3 12hr old  (405) larva L3 puffstage 1-2  (534) larva L3 puffstage 3-6  (319) larva L3 puffstage 7-9  (219) white prepupae new  (196) white prepupae 12hr  (338) white prepupae 24hr  (254) pupae 2d postWPP  (151) pupae 3d postWPP  (100) pupae 4d postWPP  (232) adult male 01day  (265) adult male 05day  (219) adult male 30day  (212) adult female 01day  (396) adult female 05day  (307) adult female 30day  (318) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  (202) embryo 02-04hr    33 embryo 04-06hr    18 embryo 06-08hr    21 embryo 08-10hr    38 embryo 10-12hr    87 embryo 12-14hr    69 embryo 14-16hr  (154) embryo 16-18hr  (176) embryo 18-20hr  (159) embryo 20-22hr  (139) embryo 22-24hr  (161) larva L1  (209) larva L2  (318) larva L3 12hr old  (405) larva L3 puffstage 1-2  (534) larva L3 puffstage 3-6  (319) larva L3 puffstage 7-9  (219) white prepupae new  (196) white prepupae 12hr  (338) white prepupae 24hr  (254) pupae 2d postWPP  (151) pupae 3d postWPP    100 pupae 4d postWPP  (232) adult male 01day  (265) adult male 05day  (219) adult male 30day  (212) adult female 01day  (396) adult female 05day  (307) adult female 30day  (318) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    202 embryo 02-04hr    33 embryo 04-06hr    18 embryo 06-08hr    21 embryo 08-10hr    38 embryo 10-12hr    87 embryo 12-14hr    69 embryo 14-16hr    154 embryo 16-18hr    176 embryo 18-20hr    159 embryo 20-22hr    139 embryo 22-24hr    161 larva L1    209 larva L2    318 larva L3 12hr old    405 larva L3 puffstage 1-2    534 larva L3 puffstage 3-6    319 larva L3 puffstage 7-9    219 white prepupae new    196 white prepupae 12hr    338 white prepupae 24hr    254 pupae 2d postWPP    151 pupae 3d postWPP    100 pupae 4d postWPP    232 adult male 01day    265 adult male 05day    219 adult male 30day    212 adult female 01day    396 adult female 05day    307 adult female 30day    318 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    202 embryo 02-04hr    33 embryo 04-06hr    18 embryo 06-08hr    21 embryo 08-10hr    38 embryo 10-12hr    87 embryo 12-14hr    69 embryo 14-16hr    154 embryo 16-18hr    176 embryo 18-20hr    159 embryo 20-22hr    139 embryo 22-24hr    161 larva L1    209 larva L2    318 larva L3 12hr old    405 larva L3 puffstage 1-2    534 larva L3 puffstage 3-6    319 larva L3 puffstage 7-9    219 white prepupae new    196 white prepupae 12hr    338 white prepupae 24hr    254 pupae 2d postWPP    151 pupae 3d postWPP    100 pupae 4d postWPP    232 adult male 01day    265 adult male 05day    219 adult male 30day    212 adult female 01day    396 adult female 05day    307 adult female 30day    318 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (202) embryo 02-04hr  (33) embryo 04-06hr    18 embryo 06-08hr    21 embryo 08-10hr  (38) embryo 10-12hr  (87) embryo 12-14hr  (69) embryo 14-16hr  (154) embryo 16-18hr  (176) embryo 18-20hr  (159) embryo 20-22hr  (139) embryo 22-24hr  (161) larva L1  (209) larva L2  (318) larva L3 12hr old  (405) larva L3 puffstage 1-2  (534) larva L3 puffstage 3-6  (319) larva L3 puffstage 7-9  (219) white prepupae new  (196) white prepupae 12hr  (338) white prepupae 24hr  (254) pupae 2d postWPP  (151) pupae 3d postWPP  (100) pupae 4d postWPP  (232) adult male 01day  (265) adult male 05day  (219) adult male 30day  (212) adult female 01day  (396) adult female 05day  (307) adult female 30day  (318) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  (202) embryo 02-04hr    33 embryo 04-06hr    18 embryo 06-08hr    21 embryo 08-10hr    38 embryo 10-12hr    87 embryo 12-14hr    69 embryo 14-16hr  (154) embryo 16-18hr  (176) embryo 18-20hr  (159) embryo 20-22hr  139 embryo 22-24hr  (161) larva L1  (209) larva L2  (318) larva L3 12hr old  (405) larva L3 puffstage 1-2  (534) larva L3 puffstage 3-6  (319) larva L3 puffstage 7-9  (219) white prepupae new  (196) white prepupae 12hr  (338) white prepupae 24hr  (254) pupae 2d postWPP  (151) pupae 3d postWPP    100 pupae 4d postWPP  (232) adult male 01day  (265) adult male 05day  (219) adult male 30day  (212) adult female 01day  (396) adult female 05day  (307) adult female 30day  (318) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    202 embryo 02-04hr    33 embryo 04-06hr    18 embryo 06-08hr    21 embryo 08-10hr    38 embryo 10-12hr    87 embryo 12-14hr    69 embryo 14-16hr    154 embryo 16-18hr    176 embryo 18-20hr    159 embryo 20-22hr    139 embryo 22-24hr    161 larva L1    209 larva L2    318 larva L3 12hr old    405 larva L3 puffstage 1-2    534 larva L3 puffstage 3-6    319 larva L3 puffstage 7-9    219 white prepupae new    196 white prepupae 12hr    338 white prepupae 24hr    254 pupae 2d postWPP    151 pupae 3d postWPP    100 pupae 4d postWPP    232 adult male 01day    265 adult male 05day    219 adult male 30day    212 adult female 01day    396 adult female 05day    307 adult female 30day    318 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    271 Schneider line 2 Sg4    294 embryonic 1182-4H    153 embryonic GM2    160 embryonic Kc167    122 embryonic S1    201 embryonic S3    235 leg disc CME L1    291 wing disc CME-W2    134 wing disc ML-DmD8    181 wing disc ML-DmD9    297 wing disc ML-DmD16-c3    226 wing disc ML-DmD21    509 wing disc ML-DmD32    262 haltere disc ML-DmD17-c3    218 eye-antennal disc ML-DmD11    319 antennal disc ML-DmD20-c5    549 mixed discs ML-DmD4-c1    413 CNS ML-DmBG1-c1    116 CNS ML-DmBG2-c2    101 tumorous blood cells mbn2    119 ovary fGS/OSS    170 ovary OSC    106 ovary OSS    101 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (271) Schneider line 2 Sg4  (294) embryonic 1182-4H  (153) embryonic GM2  (160) embryonic Kc167  (122) embryonic S1  (201) embryonic S3  (235) leg disc CME L1  (291) wing disc CME-W2  (134) wing disc ML-DmD8  (181) wing disc ML-DmD9  (297) wing disc ML-DmD16-c3  (226) wing disc ML-DmD21  (509) wing disc ML-DmD32  (262) haltere disc ML-DmD17-c3  (218) eye-antennal disc ML-DmD11  (319) antennal disc ML-DmD20-c5  (549) mixed discs ML-DmD4-c1  (413) CNS ML-DmBG1-c1  (116) CNS ML-DmBG2-c2  (101) tumorous blood cells mbn2  (119) ovary fGS/OSS  (170) ovary OSC  (106) ovary OSS  (101) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+  (271) Schneider line 2 Sg4  (294) embryonic 1182-4H  (153) embryonic GM2  (160) embryonic Kc167  (122) embryonic S1  (201) embryonic S3  (235) leg disc CME L1  (291) wing disc CME-W2  (134) wing disc ML-DmD8  (181) wing disc ML-DmD9  (297) wing disc ML-DmD16-c3  (226) wing disc ML-DmD21  (509) wing disc ML-DmD32  (262) haltere disc ML-DmD17-c3  (218) eye-antennal disc ML-DmD11  (319) antennal disc ML-DmD20-c5  (549) mixed discs ML-DmD4-c1  (413) CNS ML-DmBG1-c1  (116) CNS ML-DmBG2-c2  101 tumorous blood cells mbn2  (119) ovary fGS/OSS  (170) ovary OSC  106 ovary OSS  101 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    271 Schneider line 2 Sg4    294 embryonic 1182-4H    153 embryonic GM2    160 embryonic Kc167    122 embryonic S1    201 embryonic S3    235 leg disc CME L1    291 wing disc CME-W2    134 wing disc ML-DmD8    181 wing disc ML-DmD9    297 wing disc ML-DmD16-c3    226 wing disc ML-DmD21    509 wing disc ML-DmD32    262 haltere disc ML-DmD17-c3    218 eye-antennal disc ML-DmD11    319 antennal disc ML-DmD20-c5    549 mixed discs ML-DmD4-c1    413 CNS ML-DmBG1-c1    116 CNS ML-DmBG2-c2    101 tumorous blood cells mbn2    119 ovary fGS/OSS    170 ovary OSC    106 ovary OSS    101 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    271 Schneider line 2 Sg4    294 embryonic 1182-4H    153 embryonic GM2    160 embryonic Kc167    122 embryonic S1    201 embryonic S3    235 leg disc CME L1    291 wing disc CME-W2    134 wing disc ML-DmD8    181 wing disc ML-DmD9    297 wing disc ML-DmD16-c3    226 wing disc ML-DmD21    509 wing disc ML-DmD32    262 haltere disc ML-DmD17-c3    218 eye-antennal disc ML-DmD11    319 antennal disc ML-DmD20-c5    549 mixed discs ML-DmD4-c1    413 CNS ML-DmBG1-c1    116 CNS ML-DmBG2-c2    101 tumorous blood cells mbn2    119 ovary fGS/OSS    170 ovary OSC    106 ovary OSS    101 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (271) Schneider line 2 Sg4  (294) embryonic 1182-4H  (153) embryonic GM2  (160) embryonic Kc167  (122) embryonic S1  (201) embryonic S3  (235) leg disc CME L1  (291) wing disc CME-W2  (134) wing disc ML-DmD8  (181) wing disc ML-DmD9  (297) wing disc ML-DmD16-c3  (226) wing disc ML-DmD21  (509) wing disc ML-DmD32  (262) haltere disc ML-DmD17-c3  (218) eye-antennal disc ML-DmD11  (319) antennal disc ML-DmD20-c5  (549) mixed discs ML-DmD4-c1  (413) CNS ML-DmBG1-c1  (116) CNS ML-DmBG2-c2  (101) tumorous blood cells mbn2  (119) ovary fGS/OSS  (170) ovary OSC  (106) ovary OSS  (101) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+  (271) Schneider line 2 Sg4  (294) embryonic 1182-4H  (153) embryonic GM2  (160) embryonic Kc167  122 embryonic S1  (201) embryonic S3  (235) leg disc CME L1  (291) wing disc CME-W2  134 wing disc ML-DmD8  (181) wing disc ML-DmD9  (297) wing disc ML-DmD16-c3  (226) wing disc ML-DmD21  (509) wing disc ML-DmD32  (262) haltere disc ML-DmD17-c3  (218) eye-antennal disc ML-DmD11  (319) antennal disc ML-DmD20-c5  (549) mixed discs ML-DmD4-c1  (413) CNS ML-DmBG1-c1  116 CNS ML-DmBG2-c2  101 tumorous blood cells mbn2  119 ovary fGS/OSS  (170) ovary OSC  106 ovary OSS  101 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    271 Schneider line 2 Sg4    294 embryonic 1182-4H    153 embryonic GM2    160 embryonic Kc167    122 embryonic S1    201 embryonic S3    235 leg disc CME L1    291 wing disc CME-W2    134 wing disc ML-DmD8    181 wing disc ML-DmD9    297 wing disc ML-DmD16-c3    226 wing disc ML-DmD21    509 wing disc ML-DmD32    262 haltere disc ML-DmD17-c3    218 eye-antennal disc ML-DmD11    319 antennal disc ML-DmD20-c5    549 mixed discs ML-DmD4-c1    413 CNS ML-DmBG1-c1    116 CNS ML-DmBG2-c2    101 tumorous blood cells mbn2    119 ovary fGS/OSS    170 ovary OSC    106 ovary OSS    101 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    307 cold shock, 4-day adult    274 heat shock, 4-day adult    396 Cadmium 50 mM 6 hrs, larvae L3    855 Cadmium 50 mM 12 hrs, larvae L3    510 Cadmium 50 mM 48 hrs, 4-day adult    401 Cadmium 100 mM 48 hrs, 4-day adult    204 Copper 0.5 mM 12 hrs, larvae L3    880 Copper 15 mM 48 hrs, 4-day adult    117 Zinc 5 mM 12 hrs, larvae L3    459 Zinc 4.5 mM 48 hrs, 4-day adult    139 Ethanol 2.5% 3 hrs, larvae L3    262 Ethanol 5% 3 hrs, larvae L3    740 Ethanol 10% 3 hrs, larvae L3    641 Caffeine 1.5 mg/ml 4 hrs, larvae L3    562 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    214 Caffeine 25 mg/ml 48 hrs, 4-day adult    268 Paraquat 5 mM 48 hrs, 4-day adult    232 Paraquat 10 mM 48 hrs, 4-day adult    221 Rotenone 2 μg 12 hrs, larvae L3    824 Rotenone 8 μg 12 hrs, larvae L3    1046 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (307) cold shock, 4-day adult  (274) heat shock, 4-day adult  (396) Cadmium 50 mM 6 hrs, larvae L3  (855) Cadmium 50 mM 12 hrs, larvae L3  (510) Cadmium 50 mM 48 hrs, 4-day adult  (401) Cadmium 100 mM 48 hrs, 4-day adult  (204) Copper 0.5 mM 12 hrs, larvae L3  (880) Copper 15 mM 48 hrs, 4-day adult  (117) Zinc 5 mM 12 hrs, larvae L3  (459) Zinc 4.5 mM 48 hrs, 4-day adult  (139) Ethanol 2.5% 3 hrs, larvae L3  (262) Ethanol 5% 3 hrs, larvae L3  (740) Ethanol 10% 3 hrs, larvae L3  (641) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (562) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (214) Caffeine 25 mg/ml 48 hrs, 4-day adult  (268) Paraquat 5 mM 48 hrs, 4-day adult  (232) Paraquat 10 mM 48 hrs, 4-day adult  (221) Rotenone 2 μg 12 hrs, larvae L3  (824) Rotenone 8 μg 12 hrs, larvae L3  (1046) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult  (307) cold shock, 4-day adult  (274) heat shock, 4-day adult  (396) Cadmium 50 mM 6 hrs, larvae L3  (855) Cadmium 50 mM 12 hrs, larvae L3  (510) Cadmium 50 mM 48 hrs, 4-day adult  (401) Cadmium 100 mM 48 hrs, 4-day adult  (204) Copper 0.5 mM 12 hrs, larvae L3  (880) Copper 15 mM 48 hrs, 4-day adult  (117) Zinc 5 mM 12 hrs, larvae L3  (459) Zinc 4.5 mM 48 hrs, 4-day adult  (139) Ethanol 2.5% 3 hrs, larvae L3  (262) Ethanol 5% 3 hrs, larvae L3  (740) Ethanol 10% 3 hrs, larvae L3  (641) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (562) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (214) Caffeine 25 mg/ml 48 hrs, 4-day adult  (268) Paraquat 5 mM 48 hrs, 4-day adult  (232) Paraquat 10 mM 48 hrs, 4-day adult  (221) Rotenone 2 μg 12 hrs, larvae L3  (824) Rotenone 8 μg 12 hrs, larvae L3  (1046) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    307 cold shock, 4-day adult    274 heat shock, 4-day adult    396 Cadmium 50 mM 6 hrs, larvae L3    855 Cadmium 50 mM 12 hrs, larvae L3    510 Cadmium 50 mM 48 hrs, 4-day adult    401 Cadmium 100 mM 48 hrs, 4-day adult    204 Copper 0.5 mM 12 hrs, larvae L3    880 Copper 15 mM 48 hrs, 4-day adult    117 Zinc 5 mM 12 hrs, larvae L3    459 Zinc 4.5 mM 48 hrs, 4-day adult    139 Ethanol 2.5% 3 hrs, larvae L3    262 Ethanol 5% 3 hrs, larvae L3    740 Ethanol 10% 3 hrs, larvae L3    641 Caffeine 1.5 mg/ml 4 hrs, larvae L3    562 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    214 Caffeine 25 mg/ml 48 hrs, 4-day adult    268 Paraquat 5 mM 48 hrs, 4-day adult    232 Paraquat 10 mM 48 hrs, 4-day adult    221 Rotenone 2 μg 12 hrs, larvae L3    824 Rotenone 8 μg 12 hrs, larvae L3    1046 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    307 cold shock, 4-day adult    274 heat shock, 4-day adult    396 Cadmium 50 mM 6 hrs, larvae L3    855 Cadmium 50 mM 12 hrs, larvae L3    510 Cadmium 50 mM 48 hrs, 4-day adult    401 Cadmium 100 mM 48 hrs, 4-day adult    204 Copper 0.5 mM 12 hrs, larvae L3    880 Copper 15 mM 48 hrs, 4-day adult    117 Zinc 5 mM 12 hrs, larvae L3    459 Zinc 4.5 mM 48 hrs, 4-day adult    139 Ethanol 2.5% 3 hrs, larvae L3    262 Ethanol 5% 3 hrs, larvae L3    740 Ethanol 10% 3 hrs, larvae L3    641 Caffeine 1.5 mg/ml 4 hrs, larvae L3    562 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    214 Caffeine 25 mg/ml 48 hrs, 4-day adult    268 Paraquat 5 mM 48 hrs, 4-day adult    232 Paraquat 10 mM 48 hrs, 4-day adult    221 Rotenone 2 μg 12 hrs, larvae L3    824 Rotenone 8 μg 12 hrs, larvae L3    1046 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (307) cold shock, 4-day adult  (274) heat shock, 4-day adult  (396) Cadmium 50 mM 6 hrs, larvae L3  (855) Cadmium 50 mM 12 hrs, larvae L3  (510) Cadmium 50 mM 48 hrs, 4-day adult  (401) Cadmium 100 mM 48 hrs, 4-day adult  (204) Copper 0.5 mM 12 hrs, larvae L3  (880) Copper 15 mM 48 hrs, 4-day adult  (117) Zinc 5 mM 12 hrs, larvae L3  (459) Zinc 4.5 mM 48 hrs, 4-day adult  (139) Ethanol 2.5% 3 hrs, larvae L3  (262) Ethanol 5% 3 hrs, larvae L3  (740) Ethanol 10% 3 hrs, larvae L3  (641) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (562) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (214) Caffeine 25 mg/ml 48 hrs, 4-day adult  (268) Paraquat 5 mM 48 hrs, 4-day adult  (232) Paraquat 10 mM 48 hrs, 4-day adult  (221) Rotenone 2 μg 12 hrs, larvae L3  (824) Rotenone 8 μg 12 hrs, larvae L3  (1046) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult  (307) cold shock, 4-day adult  (274) heat shock, 4-day adult  (396) Cadmium 50 mM 6 hrs, larvae L3  (855) Cadmium 50 mM 12 hrs, larvae L3  (510) Cadmium 50 mM 48 hrs, 4-day adult  (401) Cadmium 100 mM 48 hrs, 4-day adult  (204) Copper 0.5 mM 12 hrs, larvae L3  (880) Copper 15 mM 48 hrs, 4-day adult  117 Zinc 5 mM 12 hrs, larvae L3  (459) Zinc 4.5 mM 48 hrs, 4-day adult  139 Ethanol 2.5% 3 hrs, larvae L3  (262) Ethanol 5% 3 hrs, larvae L3  (740) Ethanol 10% 3 hrs, larvae L3  (641) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (562) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (214) Caffeine 25 mg/ml 48 hrs, 4-day adult  (268) Paraquat 5 mM 48 hrs, 4-day adult  (232) Paraquat 10 mM 48 hrs, 4-day adult  (221) Rotenone 2 μg 12 hrs, larvae L3  (824) Rotenone 8 μg 12 hrs, larvae L3  (1046) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    307 cold shock, 4-day adult    274 heat shock, 4-day adult    396 Cadmium 50 mM 6 hrs, larvae L3    855 Cadmium 50 mM 12 hrs, larvae L3    510 Cadmium 50 mM 48 hrs, 4-day adult    401 Cadmium 100 mM 48 hrs, 4-day adult    204 Copper 0.5 mM 12 hrs, larvae L3    880 Copper 15 mM 48 hrs, 4-day adult    117 Zinc 5 mM 12 hrs, larvae L3    459 Zinc 4.5 mM 48 hrs, 4-day adult    139 Ethanol 2.5% 3 hrs, larvae L3    262 Ethanol 5% 3 hrs, larvae L3    740 Ethanol 10% 3 hrs, larvae L3    641 Caffeine 1.5 mg/ml 4 hrs, larvae L3    562 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    214 Caffeine 25 mg/ml 48 hrs, 4-day adult    268 Paraquat 5 mM 48 hrs, 4-day adult    232 Paraquat 10 mM 48 hrs, 4-day adult    221 Rotenone 2 μg 12 hrs, larvae L3    824 Rotenone 8 μg 12 hrs, larvae L3    1046 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_20 mE1_20_mRNA_expression_cluster_02
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0037912 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG31305-RB
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal seaΔ24 viable seaBG02200 Other Phenotypes Allele mitotic cell cycle defective seaEP3364 seaunspecified seaΔ24 mitotic cell cycle defective (with Df(3R)Mx-1) seaEP3364 seaΔ24 mitotic cell cycle defective (with seaEP3364) seaΔ24 mitotic cell cycle defective (with seaΔ24) seaEP3364 Phenotype manifest in Allele condensed chromosome seaEP3364 seaΔ24 seaunspecified condensed chromosome (with Df(3R)Mx-1) seaEP3364 seaΔ24 condensed chromosome (with seaEP3364) seaΔ24 condensed chromosome (with seaΔ24) seaEP3364 embryonic/larval neuroblast seaEP3364 seaΔ24 embryonic/larval neuroblast (with Df(3R)Mx-1) seaEP3364 seaΔ24 embryonic/larval neuroblast (with seaEP3364) seaΔ24 embryonic/larval neuroblast (with seaΔ24) seaEP3364
Classical Alleles ( 13 )
For All Classical Alleles Show
Allele of sea Class Mutagen Stocks Known lesion seaCB-0520-3 1 -- seaCB-5268-3 1 -- sead03917 1 -- seaEP3364 loss of function allele P-element activity 1 Yes seaEY02678a P-element activity 1 Yes seaf03747 1 -- seaBG02200 0 Yes sead01014 0 -- sead05984 0 -- seaEP3252 P-element activity 0 Yes seaEP3435 P-element activity 0 Yes seaunspecified 0 -- seaΔ24 loss of function allele Delta2-3 0 Yes
Alleles Carried on Transgenic Constructs ( 3 )
For All Alleles Carried on Transgenic Constructs Show
Allele of sea Class Mutagen Stocks Known lesion seaHMS00936 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes seahs.PM in vitro construct - regulatory fusion 0 Yes seaKK116001 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3R)Mx-1 (Morciano et al., 2009)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{KK116001} NA P{TRiP.HMS00936} NA heat-shock construct P{hs-sea.M} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EP}fabpEP3252 NA P{EP}fabpEP3435 NA P{EP}seaEP3364 NA P{EPgy2}fabpEY02678a NA P{XP}sead01014 NA P{XP}sead03917 NA P{XP}sead05984 NA miscellaneous insertions P{GT1}seaBG02200 NA P{RS3}seaCB-0520-3 NA P{RS3}seaCB-5268-3 NA P{UASp-YFP.Rab23.S51N}01 NA P{UASp-YFP.Rab27}14 NA PBac{WH}seaf03747 NA
Gene Ontology: Function, Process & Cellular Component ( 8 unique terms )
Terms Based on Experimental Evidence ( 5 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
citrate transport inferred from direct assay (Carrisi et al., 2008) mitochondrial citrate transport inferred from mutant phenotype (Morciano et al., 2009)
Cellular Component
CV term Evidence References
lipid particle inferred from direct assay (Beller et al., 2006) mitochondrion inferred from direct assay (Morciano et al., 2009) Nebenkern inferred from direct assay (Morciano et al., 2009)
Terms Based on Predictions or Assertions ( 3 terms )
Molecular Function
CV term Evidence References
transmembrane transporter activity inferred from sequence or structural similarity (Nelson, 2000.4.10) tricarboxylate secondary active transmembrane transporter activity inferred from sequence or structural similarity with UniProtKB:P32089 (FlyBase, 1992-)
Biological Process ( 0 terms)
Cellular Component
CV term Evidence References
mitochondrial envelope inferred from sequence or structural similarity (Nelson, 2000.4.10)
Sequence Ontology: Class of Gene
	gene_with_dicistronic_mRNA (FlyBase Genome Annotators, 2002-2003) nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
sea - CG1907 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) sea - Chc anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) sea - Hsp23 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) sea - SmD3 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) sea - Tapδ anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions sea allele Gene References
External Data
Linkouts	DPiM - DPiM, Drosophila Protein interaction Map • FBgn0037912 DroID - A comprehensive database of gene and protein interactions. • FBgn0037912 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 3772221
Orthologs
OrthoDB Orthologs (43) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG60024F Dipteran inclusive ortholog search EOG67WNXH Insect inclusive ortholog search EOG6DBS9H Arthropod inclusive ortholog search EOG6W3R3T Metazoa inclusive ortholog search EOG63NM6R
Orthologs in Drosophila Species (EOG60024F)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\sea     Drosophila simulans   Dsim\GD20656 Y   Drosophila sechellia   Dsec\GM26094 Y   Drosophila erecta   Dere\GG17216 Y   Drosophila yakuba   Dyak\GE10109     Drosophila yakuba   Dyak\GE10110 Y   Drosophila ananassae   Dana\GF16639 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA26244 Y   Drosophila persimilis   Dper\GL12264 Y   Drosophila willistoni   Dwil\GK11788 Y   Drosophila virilis   Dvir\GJ10052 Y   Drosophila mojavensis   Dmoj\GI22454 Y   Drosophila grimshawi   Dgri\GH15324 Y
Orthologs in non-Drosophila Dipterans (EOG67WNXH)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL005991   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ013697
Orthologs in non-Dipteran Insects (EOG6DBS9H)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\LOC412678   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG009371   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH10940   Atta cephalotes Leafcutter ant  Acep\ACEP20123   Camponotus floridanus Florida carpenter ant  Cflo\CFLO17021   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL15772   Linepithema humile Argentine ant  Lhum\LH13956   Pogonomyrmex barbatus Red harvester ant  Pbar\PB26048   Solenopsis invicta Red fire ant  Sinv\SINV11286   Acyrthosiphon pisum Pea aphid  Apim\ACYPI007104   Bombyx mori Silkmoth  Bmor\BGIBMGA013168   Pediculus humanus Human body louse  Phum\PHUM608670   Tribolium castaneum Red flour beetle  Tcas\GLEAN_15070
Orthologs in non-Insect Arthropods (EOG6W3R3T)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\ATRX   Ixodes scapularis Deer tick  Isca\ISCW005064
Orthologs in non-Arthropod Metazoa (EOG63NM6R)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\K11H3.3   Caenorhabditis elegans Nematode  Cele\Y37B11A.3   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_006617gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_006452gn   Danio rerio Zebrafish  Drer\slc25a1   Danio rerio Zebrafish  Drer\si:dkey-178e17.1   Danio rerio Zebrafish  Drer\ENSDARG00000076381   Xenopus tropicalis Western clawed frog  Xtro\slc25a1   Gallus gallus Domestic chicken  Ggal\SLC25A1   Mus musculus House mouse  Mmus\Slc25a1   Rattus norvegicus Norway rat  Rnor\ENSRNOG00000027858   Rattus norvegicus Norway rat  Rnor\Slc25a1   Homo sapiens Human  Hsap\SLC25A1
Human Orthologs (1)
Gene OMIM HGNC Hsap\SLC25A1
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD20656 Drosophila sechellia Dsec\GM26094 Drosophila erecta Dere\GG17216 Drosophila yakuba Dyak\GE10110 Drosophila ananassae Dana\GF16639 Drosophila pseudoobscura pseudoobscura Dpse\GA26244 Drosophila persimilis Dper\GL12264 Drosophila willistoni Dwil\GK11788 Drosophila virilis Dvir\GJ10052 Drosophila mojavensis Dmoj\GI22454 Drosophila grimshawi Dgri\GH15324
Stocks & Reagents
Stocks Listed in FlyBase ( 7 )
Bloomington	33976 y1 sc* v1; P{TRiP.HMS00936}attP2 17118 w1118; P{EP}seaEP3364 fabpEP3364/TM6B, Tb1 15579 y1 w67c23; P{EPgy2}fabpEY02678a seaEY02678a P{EPgy2}Mrp4EY02678b/TM3, Sb1 Ser1
Harvard	- P{XP}sead03917 - PBac{WH}seaf03747
Kyoto	123217 w1118; P{RS3}seaCB-0520-3 123539 w1118; P{RS3}seaCB-5268-3
Genomic Clones ( 1 )
	BACR24C01 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 201 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GH01923 LD46175 RH27308
Other clones	DPiM_LD46175
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT26891 GM10469 GM12756 GM13204 RH64821 RH70327 SD12654 SD18793 SD22380 SD27967
Other clones	5917 31348 62131 66165 79171 162579 166664 214221.47 214313.42 522705 CK01.29C.C9 CK01.106A.H9 CK01.169B.E2 CK00404 Dmel_dig_014568_0617_2120 Dmel_neb_007320_0691_0326 Dmel_neb_016077_0583_2037 EC12946 EC28447 EK038503 EK049801 EK088629 EK139959 EK174143 EK187452 EK193964 EK266152 EP05826 EP13114 FGC026G02 FGM213G08 FGM227A01 FGM322H01 GH02844 GH04207 GH07025 GH15283 GH17704 GH20875 GH20924 GH21002 GH21667 GH22125 LD32657 LP08444 RE08163 RE15608 RE22810 RE25429 RE26766 RE29895 RE30984 RE32041 RE35035 RE38433 RE38533 RE40202 RE43955 RE45481 RE49362 RE51262 RE52075 RE53735 RE54373 RE54939 RE55550 RE56723 RE56780 RE58392 RE63902 RE65432 RE66411 RE71185 RE73114 RH01278 RH01652 RH02424 RH02471 RH09141 RH15364 RH18242 RH20982 RH22523 RH25259 RH26596 RH29295 RH30341 RH32028 RH37879 RH39642 RH46390 RH46669 RH48473 RH49352 RH51195 RH51824 RH56880 RH58080 RH66223 RH68415 RH71531 RM01316 RM01416 RM01616 RM01716 RP01344 RP001004112 RP001014966 RP001018561 RP001019549 RP001020259 RP001020760 RP001053084 RP003009086 RP003052292 RP003064034 RP003120659 RP003135910 RP003197292 RP003228159 RP003239516 RP003243231 RP003264229 RP003284402 RP003306531 RP003317181 RP003318159 RP003331059 RP003331533 RP003338429 RP003495497 RP003498253 RP004110844 RP004130474 RP004131661 RP004157537 RP004169919 RP004171988 RP004172296 RP004172992 RP004186133 RP004186744 RP004202933 RP004206683 RP004207971 RP004208645 RP004210722 RP004214263 RP004227512 RP004230504 RP004232125 RP004239034 RP004239124 RP004243304 RP004251751 RP004253549 RP004254238 RP004259448 RP004263023 RP004316642 RP004337674 RP004359227 RP004387528 RP004391352 RP004402193 RP004406206 RP004431550 RP004439185 RP004452918 RP004466481 RP004470961 RP004474394 RP004484606 RP004491701 RP004503384 RP004505852 RP004509692 RP004514139 RP004514452 RP004516554 RP004517297 RP004518649 RP004534048 RP004538390 RP004556069 UUGC0298 UUGC0424
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0037912 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 3772221
Antibody Information
	polyclonal (Morciano et al., 2009)
Other Information
Discoverer
Etymology
	The gene is named after the chromosome splinter ("scheggia" in Italian) phenotype of mutants. (Morciano et al., 2009)
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: sea CG6782 (Morciano et al., 2009)
Source for database merge of
Additional comments	Dicistronic annotation CG31305 split out into separate annotations for each open reading frame, CG6783 and CG6782 in release 4.2 of the genome annotation. (FlyBase Genome Annotators, 2005) One or more of the processed transcripts for this gene contain(s) two non-overlapping open reading frames (ORFs). The non-overlapping ORFs are represented by CG6783 and sea. (FlyBase Genome Annotators, 2002-2003)
Other Comments
	Nonsense-mediated mRNA decay (NMD) down-regulates a distinct splice isoform(s) of this gene. (Hansen et al., 2009)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_001032004 NM_001032005 NM_001032006 NM_001032007 RefSeq (Proteins) • NP_001027175 NP_001027176 NP_001027177 NP_001027178 DDBJ / EMBL / GenBank • AAF54654 AAF54654.1 AAF54655.2 AAL29051 AAN13508 AAN13508.1 AAN13509 AAN13509.1 AAN13510 AAN13510.1 AAN13511.1 AAN13512.1 AAN71553 AI514635 AQ073857 AQ073947 AQ074008 AX154663 AY061503 BI587043 BT001798 CC060158 Entrez Gene - A searchable database of RefSeq genes. • 3772221 UniProtKB/TrEMBL • Q7KSQ0
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Mitochondrial substrate/solute carrier (IPR018108) Mitochondrial carrier domain (IPR023395) MitoDrome - A database of annotated Dmel nuclear genes encoding mitochondrial proteins • MTDROME31305
Linkouts
	DPiM - DPiM, Drosophila Protein interaction Map • FBgn0037912 DroID - A comprehensive database of gene and protein interactions. • FBgn0037912 DRSC - Results from RNAi screens. • FBgn0037912 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0037912 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG31305-RB FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0037912 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 3772221 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 3772221 modMine - Data generated by the modENCODE project. • FBgn0037912
Synonyms & Secondary IDs ( 8 )
Reported As
Symbol Synonym	anon-WO0140519.12   CG6782 (Beller et al., 2006, Sambandan et al., 2006, Quinones-Coello, 2007, Zhang et al., 2007, Knowles-Barley et al., 2010, Carrisi et al., 2008, Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Cammarato et al., 2011) CG31305 (Giot et al., 2003, Dionne et al., 2006, Quinones-Coello, 2007, Hansen et al., 2009, Burgler and Macdonald, 2005) DmCIC (Carrisi et al., 2008, Niwa and Enya, 2011) l(3)EP3364 (Morciano et al., 2009) sea (Morciano et al., 2009) SLC25A1 (Morciano et al., 2009)
Name Synonym	scheggia (Morciano et al., 2009)
Secondary FlyBase IDs
	FBgn0044763 FBgn0051305 FBpp0088715 FBpp0088716 FBpp0088717 FBpp0088718 FBpp0088719 FBpp0088720 FBpp0088721 FBtr0089774 FBtr0089775 FBtr0089776 FBtr0089777 FBtr0089778 FBtr0089779 FBtr0089780
References ( 32 )
Generate a list of	All references relating to this gene ( 32 )
List References by type	Research paper  ( 9 ) Supplementary material  ( 8 ) Personal communication to FlyBase  ( 7 ) FlyBase analysis  ( 5 ) Curated genome annotation  ( 2 ) Patent  ( 1 )
Recent research papers ( 1 )
	Niwa and Enya, 2011, Appl. Ent. Zool. 46(4): 573--580 A mitochondrial carrier gene, CG32103, is highly expressed in the corpora allata in the fruit fly Drosophila melanogaster (Diptera: Drosophilidae). [FBrf0216542] Show all research papers ...