FB2021_01, released Feb 18, 2021

Gene: Dmel\wkd

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General Information
Symbol
Dmel\wkd
Species
D. melanogaster
Name
whacked
Annotation Symbol
CG5344
Feature Type
protein_coding_gene
FlyBase ID
FBgn0037917
Gene Model Status
Current
Stock Availability
7 publicly available
Gene Snapshot
whacked (wkd) encodes a RabGAP that catalyzes the GTPase activity of its Rab-GTP partners. Its essential substrate appears to be the product of Rab35. wkd mutations are associated with seamless tube defects in the tracheal system. [Date last reviewed: 2019-03-21]
Other Summaries
Key Links
Genomic Location
Cytogenetic map
86E11-86E11
Sequence location
3R:11,581,576..11,585,305 [+]
Recombination map

3-51

RefSeq locus
NT_033777 REGION:11581576..11585305
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (9 terms)
Molecular Function (1 term)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
enables GTPase activator activity
inferred from biological aspect of ancestor with PANTHER:PTN000537561
(assigned by GO_Central )
(Gaudet et al., 2011)
inferred from sequence or structural similarity with FLYBASE:Evi5; FB:FBgn0262740
(FlyBase Curators, 2008--)
Biological Process (5 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
involved_in lumen formation, open tracheal system
inferred from mutant phenotype
(Schottenfeld-Roames and Ghabrial, 2012)
inferred from high throughput mutant phenotype
(Ghabrial et al., 2011)
involved_in polarity specification of proximal/distal axis
inferred from mutant phenotype
(assigned by UniProt )
(Schottenfeld-Roames and Ghabrial, 2012)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
involved_in activation of GTPase activity
inferred from biological aspect of ancestor with PANTHER:PTN000537561
(assigned by GO_Central )
(Gaudet et al., 2011)
involved_in intracellular protein transport
inferred from biological aspect of ancestor with PANTHER:PTN000537561
(assigned by GO_Central )
(Gaudet et al., 2011)
involved_in regulation of GTPase activity
inferred from sequence or structural similarity with FLYBASE:Evi5; FB:FBgn0262740
(FlyBase Curators, 2008--)
Cellular Component (3 terms)
Terms Based on Experimental Evidence (3 terms)
CV Term
Evidence
References
located_in cytoplasmic side of apical plasma membrane
inferred from direct assay
(assigned by UniProt )
(Schottenfeld-Roames and Ghabrial, 2012)
located_in cytoplasm
inferred from direct assay
(assigned by UniProt )
(Schottenfeld-Roames and Ghabrial, 2012)
located_in filopodium
inferred from direct assay
(Schottenfeld-Roames and Ghabrial, 2012)
Terms Based on Predictions or Assertions (0 terms)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Gene Group (FlyBase)
RAB GTPASE ACTIVATING PROTEINS -
RabGAPs are GTPase activating proteins for Rab family GTPases. RabGAPs share a common TBC (Tre-2/Bub2/Cdc16) domain. (Adapted from PMID:15731001 and FBrf0158741).
Protein Function (UniProtKB)
Essential for ensuring the polarized growth of tracheal seamless tubes. During seamless tube morphogenesis, likely to act as a GTPase-activating protein (GAP) for Rab35 to regulate vesicle trafficking from the recycling endosomes to the lumenal apical membrane to ensure the polarized dynein motor complex-dependent growth of seamless tubes along the proximodistal axis in tracheal terminal cells. When the terminal branch lumen is growing, Rab35-GTP is active and likely directs the transport of apical membrane vesicles from the soma to the distal tip of elongating terminal cell branches thus providing a continuous supply of apical membrane components as the lumen grows. Whereas when Rab35-GDP is inactivated, presumably by this GAP, apical membrane vesicles are transported to a central location adjacent to the terminal cell nucleus.
(UniProt, Q9VGL8)
Gene Model and Products
Number of Transcripts
2
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\wkd for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Annotated transcripts do not represent all supported alternative splices within 5' UTR.

Gene model reviewed during 5.47

Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
wkd-RA
FBtr0082413
NM_141832
2054
363
wkd-RB
FBtr0082414
NM_169402
2119
363
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
wkd-PA
FBpp0081889
42.1
363
9.59
NP_650089
AAF54659
wkd-PB
FBpp0081890
42.1
363
9.59
NP_731593
AAN13513
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

363 aa isoforms: wkd-PA, wkd-PB
Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\wkd using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 1 -- 3
organism

Comment: maternally deposited

(Fisher et al., 2012)
embryonic stage 11 -- 12
garland cell primordium
(Fisher et al., 2012)
embryonic stage 13 -- 16
embryonic head epidermis
(Fisher et al., 2012)
embryonic hindgut
(Fisher et al., 2012)
embryonic/larval garland cell
(Fisher et al., 2012)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in cytoplasmic side of apical plasma membrane
inferred from direct assay
(assigned by UniProt )
(Schottenfeld-Roames and Ghabrial, 2012)
located_in cytoplasm
inferred from direct assay
(assigned by UniProt )
(Schottenfeld-Roames and Ghabrial, 2012)
located_in filopodium
inferred from direct assay
(Schottenfeld-Roames and Ghabrial, 2012)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\wkd in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 1-3
  • Stages(s) 13-16
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 3 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 7 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of wkd
Transgenic constructs containing regulatory region of wkd
Aberrations (Deficiencies and Duplications) ( 2 )
Phenotypes
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (41)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\TBC1D10A
12 of 15
Yes
Yes
Hsap\TBC1D10B
11 of 15
No
Yes
Hsap\TBC1D10C
10 of 15
No
Yes
Hsap\GRTP1
2 of 15
No
No
Hsap\SGSM3
2 of 15
No
No
Hsap\TBC1D3C
2 of 15
No
No
Hsap\TBC1D3D
2 of 15
No
No
Hsap\TBC1D3E
2 of 15
No
No
Hsap\TBC1D3H
2 of 15
No
No
Hsap\TBC1D3
2 of 15
No
No
Hsap\TBC1D3I
2 of 15
No
No
Hsap\TBC1D3K
2 of 15
No
No
Hsap\TBC1D8B
2 of 15
No
No
Hsap\TBC1D8
2 of 15
No
No
Hsap\TBC1D9B
2 of 15
No
No
Hsap\TBC1D9
2 of 15
No
No
Hsap\TBC1D26
2 of 15
No
No
Hsap\TBC1D28
2 of 15
No
No
Hsap\USP6NL
2 of 15
No
No
Hsap\RABGAP1
1 of 15
No
No
Hsap\RABGAP1L
1 of 15
No
No
Hsap\SGSM1
1 of 15
No
No
Hsap\SGSM2
1 of 15
No
No
Hsap\TBC1D2B
1 of 15
No
No
Hsap\TBC1D2
1 of 15
No
No
Hsap\TBC1D3B
1 of 15
No
No
Hsap\TBC1D3F
1 of 15
No
No
Hsap\TBC1D3G
1 of 15
No
No
Hsap\TBC1D3J
1 of 15
No
No
Hsap\TBC1D5
1 of 15
No
No
Hsap\TBC1D12
1 of 15
No
Yes
Hsap\TBC1D13
1 of 15
No
No
Hsap\TBC1D14
1 of 15
No
Yes
Hsap\TBC1D15
1 of 15
No
No
Hsap\TBC1D16
1 of 15
No
No
Hsap\TBC1D17
1 of 15
No
No
Hsap\TBC1D21
1 of 15
No
No
Hsap\TBC1D25
1 of 15
No
No
Hsap\TBC1D29P
1 of 15
No
Yes
Hsap\TBC1D30
1 of 15
No
No
Hsap\USP6
1 of 15
No
No
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (26)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Tbc1d10a
13 of 15
Yes
Yes
Mmus\Tbc1d10b
10 of 15
No
Yes
Mmus\Tbc1d10c
9 of 15
No
Yes
Mmus\Grtp1
2 of 15
No
No
Mmus\Sgsm3
2 of 15
No
No
Mmus\Tbc1d8b
2 of 15
No
No
Mmus\Tbc1d8
2 of 15
No
No
Mmus\Tbc1d9b
2 of 15
No
No
Mmus\Tbc1d9
2 of 15
No
No
Mmus\Rabgap1l
1 of 15
No
No
Mmus\Rabgap1
1 of 15
No
No
Mmus\Sgsm1
1 of 15
No
No
Mmus\Sgsm2
1 of 15
No
No
Mmus\Tbc1d2b
1 of 15
No
No
Mmus\Tbc1d2
1 of 15
No
No
Mmus\Tbc1d5
1 of 15
No
No
Mmus\Tbc1d12
1 of 15
No
Yes
Mmus\Tbc1d13
1 of 15
No
No
Mmus\Tbc1d14
1 of 15
No
Yes
Mmus\Tbc1d15
1 of 15
No
No
Mmus\Tbc1d16
1 of 15
No
No
Mmus\Tbc1d17
1 of 15
No
No
Mmus\Tbc1d21
1 of 15
No
No
Mmus\Tbc1d25
1 of 15
No
No
Mmus\Tbc1d30
1 of 15
No
No
Mmus\Usp6nl
1 of 15
No
No
Rattus norvegicus (Norway rat) (23)
Rnor\Tbc1d10a
11 of 13
Yes
Yes
Rnor\Tbc1d10b
10 of 13
No
Yes
Rnor\Tbc1d10c
9 of 13
No
Yes
Rnor\Usp6nl
2 of 13
No
No
Rnor\Rabgap1l
1 of 13
No
No
Rnor\Rabgap1
1 of 13
No
No
Rnor\Sgsm1
1 of 13
No
No
Rnor\Sgsm2
1 of 13
No
No
Rnor\Sgsm3
1 of 13
No
No
Rnor\Tbc1d2b
1 of 13
No
No
Rnor\Tbc1d2
1 of 13
No
No
Rnor\Tbc1d5
1 of 13
No
No
Rnor\Tbc1d8
1 of 13
No
No
Rnor\Tbc1d9b
1 of 13
No
No
Rnor\Tbc1d9
1 of 13
No
No
Rnor\Tbc1d12
1 of 13
No
Yes
Rnor\Tbc1d13
1 of 13
No
No
Rnor\Tbc1d14
1 of 13
No
Yes
Rnor\Tbc1d15
1 of 13
No
No
Rnor\Tbc1d16
1 of 13
No
No
Rnor\Tbc1d17
1 of 13
No
No
Rnor\Tbc1d25
1 of 13
No
No
Rnor\Tbc1d30
1 of 13
No
No
Xenopus tropicalis (Western clawed frog) (16)
Xtro\tbc1d10a
11 of 12
Yes
Yes
Xtro\tbc1d10b
8 of 12
No
Yes
Xtro\grtp1
2 of 12
No
No
Xtro\LOC100496433
1 of 12
No
No
Xtro\rabgap1l
1 of 12
No
No
Xtro\sgsm1
1 of 12
No
No
Xtro\sgsm2
1 of 12
No
No
Xtro\sgsm3
1 of 12
No
No
Xtro\tbc1d2b
1 of 12
No
No
Xtro\tbc1d5
1 of 12
No
No
Xtro\tbc1d8b
1 of 12
No
No
Xtro\tbc1d9b
1 of 12
No
No
Xtro\tbc1d9
1 of 12
No
No
Xtro\tbc1d14
1 of 12
No
Yes
Xtro\tbc1d16
1 of 12
No
No
Xtro\usp6nl
1 of 12
No
No
Danio rerio (Zebrafish) (32)
Drer\tbc1d10ab
11 of 15
Yes
Yes
Drer\tbc1d10c
6 of 15
No
Yes
Drer\tbc1d10aa
5 of 15
No
Yes
Drer\grtp1a
2 of 15
No
No
Drer\sgsm3
2 of 15
No
No
Drer\si:ch211-266k8.4
2 of 15
No
No
Drer\si:ch211-288d18.1
2 of 15
No
No
Drer\si:dkey-110k5.6
2 of 15
No
No
Drer\si:dkeyp-19e1.3
2 of 15
No
No
Drer\tbc1d9
2 of 15
No
No
Drer\usp6nl
2 of 15
No
No
Drer\grtp1b
1 of 15
No
No
Drer\rabgap1l2
1 of 15
No
No
Drer\rabgap1l
1 of 15
No
No
Drer\sgsm1a
1 of 15
No
No
Drer\sgsm1b
1 of 15
No
No
Drer\sgsm2
1 of 15
No
No
Drer\si:dkey-238d18.4
1 of 15
No
No
Drer\tbc1d2b
1 of 15
No
No
Drer\tbc1d2
1 of 15
No
No
Drer\tbc1d5
1 of 15
No
No
Drer\tbc1d9b
1 of 15
No
No
Drer\tbc1d10b
1 of 15
No
Yes
Drer\tbc1d12a
1 of 15
No
Yes
Drer\tbc1d12b
1 of 15
No
Yes
Drer\tbc1d13
1 of 15
No
No
Drer\tbc1d14
1 of 15
No
Yes
Drer\tbc1d15
1 of 15
No
No
Drer\tbc1d16
1 of 15
No
No
Drer\tbc1d17
1 of 15
No
No
Drer\tbc1d25
1 of 15
No
No
Drer\tbc1d30
1 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (14)
Cele\tbc-10
12 of 15
Yes
Yes
Cele\tbc-9
2 of 15
No
No
Cele\tbc-17
2 of 15
No
No
Cele\tbc-18
2 of 15
No
No
Cele\tbc-2
1 of 15
No
No
Cele\tbc-6
1 of 15
No
No
Cele\tbc-8
1 of 15
No
No
Cele\tbc-11
1 of 15
No
No
Cele\tbc-12
1 of 15
No
Yes
Cele\tbc-13
1 of 15
No
No
Cele\tbc-14
1 of 15
No
No
Cele\tbc-16
1 of 15
No
No
Cele\tbc-19
1 of 15
No
No
Cele\Y48E1C.4
1 of 15
No
Yes
Arabidopsis thaliana (thale-cress) (2)
Atha\AT3G02460
4 of 9
Yes
No
Atha\PAM1
3 of 9
No
No
Saccharomyces cerevisiae (Brewer's yeast) (8)
Scer\GYL1
2 of 15
Yes
No
Scer\GYP5
2 of 15
Yes
No
Scer\MDR1
2 of 15
Yes
No
Scer\MSB3
2 of 15
Yes
No
Scer\MSB4
2 of 15
Yes
No
Scer\BUB2
1 of 15
No
No
Scer\GYP6
1 of 15
No
No
Scer\GYP7
1 of 15
No
No
Schizosaccharomyces pombe (Fission yeast) (7)
Spom\gyp2
1 of 12
Yes
No
Spom\gyp3
1 of 12
Yes
No
Spom\gyp51
1 of 12
Yes
No
Spom\SPAC4G8.04
1 of 12
Yes
No
Spom\SPBC215.01
1 of 12
Yes
No
Spom\SPBC1778.09
1 of 12
Yes
No
Spom\SPCC1620.12c
1 of 12
Yes
No
Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG09190ANF )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00010386
Drosophila simulans
Dsim\GD18765
Drosophila sechellia
Dsec\GM23956
Drosophila erecta
Dere\GG18255
Drosophila yakuba
Dyak\GE24183
Drosophila ananassae
Dana\GF18380
Drosophila pseudoobscura pseudoobscura
Dpse\GA18817
Drosophila pseudoobscura pseudoobscura
Dpse\GA22257
Drosophila persimilis
Dper\GL12234
Drosophila willistoni
Dwil\GK14254
Drosophila virilis
Dvir\GJ11103
Drosophila mojavensis
Dmoj\GI10296
Drosophila grimshawi
Dgri\GH23093
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091506X3 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17015632
Glossina morsitans
Tsetse fly
Gmor\GMOY009054
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_10100
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL004131
Anopheles darlingi
American malaria mosquito
Adar\ADAC005958
Anopheles gambiae
Malaria mosquito
Agam\AGAP001953
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ011634
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W08QG )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA012816
Danaus plexippus
Monarch butterfly
Dple\DPOGS206865-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL014042
Apis florea
Little honeybee
Aflo\2152282708
Apis mellifera
Western honey bee
Amel\RabGAP7
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP17864
Bombus terrestris
Buff-tailed bumblebee
Bter\15206380
Linepithema humile
Argentine ant
Lhum\LH13550
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:001d56
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG006994
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_09380
Tribolium castaneum
Red flour beetle
Tcas\GLEAN_15650
Pediculus humanus
Human body louse
Phum\PHUM255350
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI003432
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_09922
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X08M5 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR008834
Ixodes scapularis
Black-legged tick
Isca\ISCW005174
Stegodyphus mimosarum
African social velvet spider
Smim\KFM61189.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur32g00140
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_47414
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G07CB )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\SPU_015192gn
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Tbc1d10b
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000014896
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000014895
Gallus gallus
Domestic chicken
Ggal\TBC1D10A
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (19)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
RN-tre
5 of 10
CG5916
4 of 10
CG12241
4 of 10
Tbc1d8-9
4 of 10
CG1695
3 of 10
CG8155
3 of 10
CG42795
3 of 10
GAPcenA
3 of 10
GAPsec
3 of 10
TBC1D5
3 of 10
Tbc1d15-17
3 of 10
TBC1D16
3 of 10
tbc
3 of 10
CG4041
2 of 10
CG5745
2 of 10
Evi5
2 of 10
plx
2 of 10
CG3703
1 of 10
GstT3
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    TBC1D10A; TBC1 domain family member 10A
    12 of 15
    610020
        TBC1D10B; TBC1 domain family member 10B
        11 of 15
        613620
            TBC1D10C; TBC1 domain family member 10C
            10 of 15
            610831
                Functional Complementation Data
                Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
                Interactions
                Summary of Physical Interactions
                esyN Network Diagram
                Interactions Browser
                Summary of Genetic Interactions
                esyN Network Diagram
                esyN Network Key:
                Suppression
                Enhancement
                View in Interactions Browser
                Please look at the allele data for full details of the genetic interactions
                Starting gene(s)
                Interaction type
                Interacting gene(s)
                Reference
                wkd
                suppressible
                Rab35
                (Schottenfeld-Roames and Ghabrial, 2012)
                Starting gene(s)
                Interaction type
                Interacting gene(s)
                Reference
                External Data
                Linkouts
                BioGRID - A database of protein and genetic interactions.
                DroID - A comprehensive database of gene and protein interactions.
                InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
                MIST (protein-protein) - An integrated Molecular Interaction Database
                Pathways
                Signaling Pathways (FlyBase)
                Metabolic Pathways
                External Data
                Linkouts
                Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                Genomic Location and Detailed Mapping Data
                Chromosome (arm)
                3R
                Recombination map

                3-51

                Cytogenetic map
                86E11-86E11
                Sequence location
                3R:11,581,576..11,585,305 [+]
                FlyBase Computed Cytological Location
                Cytogenetic map
                Evidence for location
                86E11-86E11
                Limits computationally determined from genome sequence between P{PZ}tho1&P{PZ}l(3)0462905275 and P{EP}Lk6EP886
                Experimentally Determined Cytological Location
                Cytogenetic map
                Notes
                References
                Location based on deficiency mapping with Df(3R)Exel6276.
                (Ghabrial et al., 2011)
                Experimentally Determined Recombination Data
                Location

                3-51

                (FlyBase, 2016)

                3-48.6

                (Comeron et al., 2012)
                Left of (cM)
                Right of (cM)
                Notes
                Stocks and Reagents
                Stocks (7)
                Genomic Clones (13)
                 

                Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

                cDNA Clones (71)
                 

                Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

                cDNA clones, fully sequenced
                BDGP DGC clones
                Other clones
                Drosophila Genomics Resource Center cDNA clones

                For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

                cDNA Clones, End Sequenced (ESTs)
                BDGP DGC clones
                Other clones
                RNAi and Array Information
                Linkouts
                DRSC - Results frm RNAi screens
                GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                Antibody Information
                Laboratory Generated Antibodies
                 
                Commercially Available Antibodies
                 
                Other Information
                Relationship to Other Genes
                Source for database identify of

                Source for identity of: wkd CG5344

                (Ghabrial, 2005.3.2)
                Source for database merge of
                Additional comments

                FlyBase curator comment: the insertion in the "e01976" Exelixis line (PBac{RB}CG5342e01976) was originally assigned to the wkd gene in FBrf0179797, resulting in the "wkde01976" (FBal0161289) allele. However, FBrf0182831 shows that the insertion is actually within CG5342.

                (Bloomington Drosophila Stock Center, 2004.11.6)
                Other Comments

                May be required for tracheal terminal cell growth and branching.

                (Ghabrial et al., 2005)
                Origin and Etymology
                Discoverer
                Etymology
                Identification
                External Crossreferences and Linkouts ( 34 )
                Sequence Crossreferences
                NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
                Other crossreferences
                BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
                Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
                Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
                Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
                Flygut - An atlas of the Drosophila adult midgut
                GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
                InterPro - A database of protein families, domains and functional sites
                KEGG Genes - Molecular building blocks of life in the genomic space.
                modMine - A data warehouse for the modENCODE project
                Linkouts
                BioGRID - A database of protein and genetic interactions.
                DPiM - Drosophila Protein interaction map
                DroID - A comprehensive database of gene and protein interactions.
                DRSC - Results frm RNAi screens
                FLIGHT - Cell culture data for RNAi and other high-throughput technologies
                FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
                FlyMine - An integrated database for Drosophila genomics
                InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
                MIST (protein-protein) - An integrated Molecular Interaction Database
                Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                Synonyms and Secondary IDs (6)
                Datasets (0)
                Study focus (0)
                Experimental Role
                Project
                Project Type
                Title
                References (41)