FB2021_02, released April 13, 2021

Gene: Dmel\KLHL18

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General Information
Symbol
Dmel\KLHL18
Species
D. melanogaster
Name
Kelch like family member 18
Annotation Symbol
CG3571
Feature Type
protein_coding_gene
FlyBase ID
FBgn0037978
Gene Model Status
Current
Stock Availability
6 publicly available
Gene Summary
Contribute a Gene Snapshot for this gene.
All Summaries
Also Known As

dKLHL18

Key Links
Genomic Location
Cytogenetic map
87A4-87A5
Sequence location
3R:12,007,476..12,010,434 [-]
Recombination map
3-51
RefSeq locus
NT_033777 REGION:12007476..12010434
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (4 terms)
Molecular Function (1 term)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
enables protein homodimerization activity
inferred from direct assay
(Zhou et al., 2015)
Terms Based on Predictions or Assertions (0 terms)
Biological Process (2 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
involved_in imaginal disc fusion, thorax closure
inferred from mutant phenotype
(Fujiyama-Nakamura et al., 2009)
involved_in protein autoubiquitination
inferred from direct assay
(Zhou et al., 2015)
Terms Based on Predictions or Assertions (0 terms)
Cellular Component (1 term)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
part_of Cul3-RING ubiquitin ligase complex
inferred from genetic interaction with FLYBASE:Cul3; FB:FBgn0261268
(Fujiyama-Nakamura et al., 2009)
inferred from physical interaction with FLYBASE:Cul3; FB:FBgn0261268
(Fujiyama-Nakamura et al., 2009)
Terms Based on Predictions or Assertions (0 terms)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Gene Model and Products
Number of Transcripts
3
Number of Unique Polypeptides
2

Please see the JBrowse view of Dmel\KLHL18 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Gene model reviewed during 5.47

Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
KLHL18-RA
FBtr0082556
NM_141886
2101
575
KLHL18-RB
FBtr0082557
NM_169446
2199
538
KLHL18-RC
FBtr0335434
NM_001275565
2292
575
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
KLHL18-PA
FBpp0082029
64.9
575
6.51
NP_650143
AAF54737
KLHL18-PB
FBpp0082030
60.4
538
6.61
NP_731664
AAF54738
KLHL18-PC
FBpp0307415
64.9
575
6.51
NP_001262494
AGB95876
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

575 aa isoforms: KLHL18-PA, KLHL18-PC
Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Nucleotide / Polypeptide Records
 
UniProt
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\KLHL18 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 1 -- 3
organism

Comment: maternally deposited

(Fisher et al., 2012)
embryonic stage 4 -- 6
organism
(Fisher et al., 2012)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
part_of Cul3-RING ubiquitin ligase complex
inferred from genetic interaction with FLYBASE:Cul3; FB:FBgn0261268
(Fujiyama-Nakamura et al., 2009)
inferred from physical interaction with FLYBASE:Cul3; FB:FBgn0261268
(Fujiyama-Nakamura et al., 2009)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\KLHL18 in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 2 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 5 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of KLHL18
Transgenic constructs containing regulatory region of KLHL18
Aberrations (Deficiencies and Duplications) ( 3 )
Phenotypes
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (28)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\KLHL18
14 of 15
Yes
Yes
Hsap\HLA-DRB4
1 of 15
No
Yes
Hsap\IPP
1 of 15
No
No
Hsap\IVNS1ABP
1 of 15
No
Yes
Hsap\KBTBD2
1 of 15
No
Yes
Hsap\KBTBD3
1 of 15
No
Yes
Hsap\KBTBD6
1 of 15
No
Yes
Hsap\KBTBD7
1 of 15
No
Yes
Hsap\KBTBD8
1 of 15
No
Yes
Hsap\KEAP1
1 of 15
No
No
Hsap\KLHL1
1 of 15
No
No
Hsap\KLHL4
1 of 15
No
No
Hsap\KLHL5
1 of 15
No
No
Hsap\KLHL6
1 of 15
No
Yes
Hsap\KLHL7
1 of 15
No
No
Hsap\KLHL8
1 of 15
No
Yes
Hsap\KLHL11
1 of 15
No
Yes
Hsap\KLHL12
1 of 15
No
Yes
Hsap\KLHL20
1 of 15
No
No
Hsap\KLHL24
1 of 15
No
Yes
Hsap\KLHL25
1 of 15
No
Yes
Hsap\KLHL28
1 of 15
No
No
Hsap\KLHL29
1 of 15
No
Yes
Hsap\KLHL30
1 of 15
No
Yes
Hsap\KLHL35
1 of 15
No
Yes
Hsap\KLHL38
1 of 15
No
Yes
Hsap\KLHL40
1 of 15
No
Yes
1  
Hsap\KLHL41
1 of 15
No
No
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (27)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Klhl18
13 of 15
Yes
Yes
Mmus\Chp1
1 of 15
No
No
Mmus\Ipp
1 of 15
No
No
Mmus\Ivns1abp
1 of 15
No
Yes
Mmus\Kbtbd2
1 of 15
No
Yes
Mmus\Kbtbd3
1 of 15
No
Yes
Mmus\Kbtbd6
1 of 15
No
Yes
Mmus\Kbtbd7
1 of 15
No
Yes
Mmus\Kbtbd8
1 of 15
No
Yes
Mmus\Keap1
1 of 15
No
No
Mmus\Klhl1
1 of 15
No
No
Mmus\Klhl4
1 of 15
No
No
Mmus\Klhl5
1 of 15
No
No
Mmus\Klhl6
1 of 15
No
Yes
Mmus\Klhl7
1 of 15
No
No
Mmus\Klhl8
1 of 15
No
Yes
Mmus\Klhl11
1 of 15
No
Yes
Mmus\Klhl12
1 of 15
No
Yes
Mmus\Klhl17
1 of 15
No
No
Mmus\Klhl24
1 of 15
No
Yes
Mmus\Klhl28
1 of 15
No
No
Mmus\Klhl29
1 of 15
No
Yes
Mmus\Klhl30
1 of 15
No
Yes
Mmus\Klhl35
1 of 15
No
Yes
Mmus\Klhl38
1 of 15
No
Yes
Mmus\Klhl40
1 of 15
No
Yes
Mmus\Klhl41
1 of 15
No
Yes
Rattus norvegicus (Norway rat) (27)
Rnor\Klhl18
9 of 13
Yes
Yes
Rnor\Ipp
1 of 13
No
No
Rnor\Ivns1abp
1 of 13
No
Yes
Rnor\Kbtbd2
1 of 13
No
Yes
Rnor\Kbtbd3
1 of 13
No
Yes
Rnor\Kbtbd6
1 of 13
No
Yes
Rnor\Kbtbd8
1 of 13
No
Yes
Rnor\Keap1
1 of 13
No
No
Rnor\Klhl1
1 of 13
No
No
Rnor\Klhl4
1 of 13
No
No
Rnor\Klhl5
1 of 13
No
No
Rnor\Klhl6
1 of 13
No
Yes
Rnor\Klhl7
1 of 13
No
No
Rnor\Klhl8
1 of 13
No
Yes
Rnor\Klhl11
1 of 13
No
Yes
Rnor\Klhl12
1 of 13
No
Yes
Rnor\Klhl17
1 of 13
No
No
Rnor\Klhl20
1 of 13
No
No
Rnor\Klhl24
1 of 13
No
Yes
Rnor\Klhl25
1 of 13
No
Yes
Rnor\Klhl28
1 of 13
No
No
Rnor\Klhl29
1 of 13
No
Yes
Rnor\Klhl30
1 of 13
No
Yes
Rnor\Klhl35
1 of 13
No
Yes
Rnor\Klhl38
1 of 13
No
Yes
Rnor\Klhl40
1 of 13
No
Yes
Rnor\Klhl41
1 of 13
No
Yes
Xenopus tropicalis (Western clawed frog) (27)
Xtro\klhl18
3 of 12
Yes
Yes
Xtro\ipp
1 of 12
No
No
Xtro\ivns1abp
1 of 12
No
Yes
Xtro\kbtbd2
1 of 12
No
Yes
Xtro\kbtbd3
1 of 12
No
Yes
Xtro\kbtbd7
1 of 12
No
Yes
Xtro\kbtbd8
1 of 12
No
Yes
Xtro\keap1
1 of 12
No
No
Xtro\klhl4
1 of 12
No
No
Xtro\klhl5
1 of 12
No
No
Xtro\klhl6
1 of 12
No
Yes
Xtro\klhl7
1 of 12
No
No
Xtro\klhl8
1 of 12
No
Yes
Xtro\klhl11
1 of 12
No
Yes
Xtro\klhl12
1 of 12
No
Yes
Xtro\klhl17
1 of 12
No
No
Xtro\klhl20
1 of 12
No
No
Xtro\klhl24
1 of 12
No
Yes
Xtro\klhl25
1 of 12
No
Yes
Xtro\klhl28
1 of 12
No
Yes
Xtro\klhl29
1 of 12
No
Yes
Xtro\klhl30
1 of 12
No
Yes
Xtro\klhl35
1 of 12
No
Yes
Xtro\klhl38
1 of 12
No
Yes
Xtro\klhl40
1 of 12
No
Yes
Xtro\klhl41
1 of 12
No
Yes
Xtro\LOC100489128
1 of 12
No
Yes
Danio rerio (Zebrafish) (35)
Drer\klhl18
8 of 15
Yes
Yes
Drer\ipp
1 of 15
No
No
Drer\ivns1abpa
1 of 15
No
Yes
Drer\ivns1abpb
1 of 15
No
Yes
Drer\kbtbd2
1 of 15
No
Yes
Drer\kbtbd3
1 of 15
No
Yes
Drer\kbtbd4
1 of 15
No
Yes
Drer\kbtbd7
1 of 15
No
Yes
Drer\kbtbd8
1 of 15
No
Yes
Drer\keap1a
1 of 15
No
No
Drer\keap1b
1 of 15
No
No
Drer\klhl4
1 of 15
No
No
Drer\klhl5
1 of 15
No
No
Drer\klhl6
1 of 15
No
Yes
Drer\klhl7
1 of 15
No
No
Drer\klhl8
1 of 15
No
Yes
Drer\klhl11
1 of 15
No
Yes
Drer\klhl17
1 of 15
No
No
Drer\klhl20
1 of 15
No
No
Drer\klhl24a
1 of 15
No
Yes
Drer\klhl24b
1 of 15
No
Yes
Drer\klhl25
1 of 15
No
Yes
Drer\klhl28
1 of 15
No
No
Drer\klhl29
1 of 15
No
Yes
Drer\klhl30
1 of 15
No
Yes
Drer\klhl35
1 of 15
No
Yes
Drer\klhl38a
1 of 15
No
Yes
Drer\klhl38b
1 of 15
No
Yes
Drer\klhl40a
1 of 15
No
Yes
Drer\klhl40b
1 of 15
No
Yes
Drer\klhl41a
1 of 15
No
Yes
Drer\klhl41b
1 of 15
No
Yes
Drer\LOC100334314
1 of 15
No
Yes
Drer\LOC108178999
1 of 15
No
Yes
Drer\si:dkey-260j18.2
1 of 15
No
Yes
Caenorhabditis elegans (Nematode, roundworm) (58)
Cele\kel-3
14 of 15
Yes
Yes
Cele\bath-1
1 of 15
No
Yes
Cele\bath-2
1 of 15
No
Yes
Cele\bath-3
1 of 15
No
Yes
Cele\bath-4
1 of 15
No
Yes
Cele\bath-5
1 of 15
No
Yes
Cele\bath-7
1 of 15
No
Yes
Cele\bath-9
1 of 15
No
Yes
Cele\bath-10
1 of 15
No
Yes
Cele\bath-13
1 of 15
No
Yes
Cele\bath-15
1 of 15
No
Yes
Cele\bath-19
1 of 15
No
Yes
Cele\bath-20
1 of 15
No
Yes
Cele\bath-21
1 of 15
No
Yes
Cele\bath-23
1 of 15
No
Yes
Cele\bath-24
1 of 15
No
Yes
Cele\bath-25
1 of 15
No
Yes
Cele\bath-26
1 of 15
No
Yes
Cele\bath-27
1 of 15
No
Yes
Cele\bath-29
1 of 15
No
Yes
Cele\bath-30
1 of 15
No
Yes
Cele\bath-31
1 of 15
No
Yes
Cele\bath-33
1 of 15
No
Yes
Cele\bath-35
1 of 15
No
Yes
Cele\bath-36
1 of 15
No
Yes
Cele\bath-38
1 of 15
No
Yes
Cele\bath-45
1 of 15
No
Yes
Cele\bath-46
1 of 15
No
Yes
Cele\bath-47
1 of 15
No
Yes
Cele\btb-1
1 of 15
No
Yes
Cele\btb-2
1 of 15
No
Yes
Cele\btb-4
1 of 15
No
Yes
Cele\btb-7
1 of 15
No
Yes
Cele\btb-8
1 of 15
No
Yes
Cele\btb-9
1 of 15
No
Yes
Cele\btb-10
1 of 15
No
Yes
Cele\btb-12
1 of 15
No
Yes
Cele\btb-15
1 of 15
No
Yes
Cele\btb-16
1 of 15
No
Yes
Cele\btb-17
1 of 15
No
Yes
Cele\C53A5.6
1 of 15
No
Yes
Cele\C53A5.9
1 of 15
No
Yes
Cele\C53A5.11
1 of 15
No
Yes
Cele\F14D2.15
1 of 15
No
Yes
Cele\hpo-9
1 of 15
No
No
Cele\ivns-1
1 of 15
No
Yes
Cele\K08E4.7
1 of 15
No
Yes
Cele\kel-8
1 of 15
No
Yes
Cele\kel-20
1 of 15
No
No
Cele\math-1
1 of 15
No
Yes
Cele\math-13
1 of 15
No
Yes
Cele\math-20
1 of 15
No
Yes
Cele\math-29
1 of 15
No
Yes
Cele\math-38
1 of 15
No
Yes
Cele\math-40
1 of 15
No
Yes
Cele\math-50
1 of 15
No
Yes
Cele\sdz-18
1 of 15
No
Yes
Cele\sdz-28
1 of 15
No
Yes
Arabidopsis thaliana (thale-cress) (40)
Atha\AFR
1 of 9
Yes
No
Atha\AT1G16250
1 of 9
Yes
Yes
Atha\AT1G19460
1 of 9
Yes
Yes
Atha\AT1G19930
1 of 9
Yes
Yes
Atha\AT1G22040
1 of 9
Yes
No
Atha\AT1G27420
1 of 9
Yes
No
Atha\AT1G30090
1 of 9
Yes
Yes
Atha\AT1G55270
1 of 9
Yes
No
Atha\AT1G67480
1 of 9
Yes
No
Atha\AT2G03460
1 of 9
Yes
Yes
Atha\AT2G29770
1 of 9
Yes
Yes
Atha\AT2G29820
1 of 9
Yes
Yes
Atha\AT2G41360
1 of 9
Yes
Yes
Atha\AT2G44030
1 of 9
Yes
Yes
Atha\AT2G44700
1 of 9
Yes
Yes
Atha\AT3G06570
1 of 9
Yes
Yes
Atha\AT3G08810
1 of 9
Yes
Yes
Atha\AT3G10510
1 of 9
Yes
Yes
Atha\AT3G24610
1 of 9
Yes
Yes
Atha\AT3G27910
1 of 9
Yes
Yes
Atha\AT3G63220
1 of 9
Yes
No
Atha\AT4G02310
1 of 9
Yes
Yes
Atha\AT4G19250
1 of 9
Yes
Yes
Atha\AT4G19330
1 of 9
Yes
Yes
Atha\AT4G25710
1 of 9
Yes
Yes
Atha\AT4G36840
1 of 9
Yes
Yes
Atha\AT4G39753
1 of 9
Yes
Yes
Atha\AT4G39760
1 of 9
Yes
Yes
Atha\AT5G01660
1 of 9
Yes
Yes
Atha\AT5G03010
1 of 9
Yes
Yes
Atha\AT5G28160
1 of 9
Yes
Yes
Atha\AT5G28180
1 of 9
Yes
Yes
Atha\AT5G38670
1 of 9
Yes
Yes
Atha\AT5G38680
1 of 9
Yes
Yes
Atha\AT5G39560
1 of 9
Yes
Yes
Atha\AT5G48980
1 of 9
Yes
Yes
Atha\AT5G51250
1 of 9
Yes
Yes
Atha\AT5G60570
1 of 9
Yes
Yes
Atha\SKIP4
1 of 9
Yes
No
Atha\SKIP6
1 of 9
Yes
No
Saccharomyces cerevisiae (Brewer's yeast) (0)
No records found.
Schizosaccharomyces pombe (Fission yeast) (0)
No records found.
Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG091904KR )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00008586
Drosophila simulans
Dsim\GD20611
Drosophila sechellia
Dsec\GM26048
Drosophila erecta
Dere\GG17168
Drosophila yakuba
Dyak\GE24559
Drosophila ananassae
Dana\GF17752
Drosophila pseudoobscura pseudoobscura
Dpse\GA17529
Drosophila persimilis
Dper\GL21584
Drosophila willistoni
Dwil\GK11665
Drosophila virilis
Dvir\GJ23685
Drosophila mojavensis
Dmoj\GI24060
Drosophila grimshawi
Dgri\GH12392
Drosophila grimshawi
Dgri\GH25262
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG0915038F )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17015630
Glossina morsitans
Tsetse fly
Gmor\GMOY009052
Mayetiola destructor
Hessian fly
Mdes\Mdes010435
Anopheles darlingi
American malaria mosquito
Adar\ADAC004892
Anopheles gambiae
Malaria mosquito
Agam\AGAP011142
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ013035
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W03LQ )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG022272
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_07008
Tribolium castaneum
Red flour beetle
Tcas\TC006676
Pediculus humanus
Human body louse
Phum\PHUM449490
Rhodnius prolixus
Kissing bug
Rpro\RPRC007120
Cimex lectularius
Bed bug
Clec\CLEC002667
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI005528
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI085804
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_01582
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X03IL )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR010077
Strigamia maritima
European centipede
Smar\SMAR001579
Ixodes scapularis
Black-legged tick
Isca\ISCW007741
Stegodyphus mimosarum
African social velvet spider
Smim\KFM59345.1
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_305899
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G04QJ )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Klhl12
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Diablo
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Klhl2
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Klhl2_1
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Sentrin
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Klhl5
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Actinfilin
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Klhl5-2
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000020003
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000006681
Ciona intestinalis
Vase tunicate
Cint\LOC100179937
Ciona intestinalis
Vase tunicate
Cint\LOC100175104
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000002846
Gallus gallus
Domestic chicken
Ggal\KLHL17
Gallus gallus
Domestic chicken
Ggal\KLHL2
Gallus gallus
Domestic chicken
Ggal\KLHL5
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000000518
Gallus gallus
Domestic chicken
Ggal\KLHL4
Gallus gallus
Domestic chicken
Ggal\KLHL1
Gallus gallus
Domestic chicken
Ggal\KLHL3
Gallus gallus
Domestic chicken
Ggal\KLHL20
Gallus gallus
Domestic chicken
Ggal\KLHL18
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (8)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
CG9426
4 of 10
CG15097
4 of 10
CG17754
4 of 10
dbo
4 of 10
Keap1
4 of 10
klhl10
3 of 10
kel
2 of 10
CG1812
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    KLHL18; kelch like family member 18
    14 of 15
        Functional Complementation Data
        Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
        Interactions
        Summary of Physical Interactions
        Summary of Genetic Interactions
        esyN Network Diagram
        esyN Network Key:
        Suppression
        Enhancement
        View in Interactions Browser
        Please look at the allele data for full details of the genetic interactions
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        KLHL18
        enhanceable
        CG5808
        (Fujiyama-Nakamura et al., 2009)
        KLHL18
        enhanceable
        CG10324
        (Fujiyama-Nakamura et al., 2009)
        KLHL18
        enhanceable
        Cul3
        (Fujiyama-Nakamura et al., 2009)
        KLHL18
        enhanceable
        l(2)37Cb
        (Fujiyama-Nakamura et al., 2009)
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        External Data
        Linkouts
        BioGRID - A database of protein and genetic interactions.
        DroID - A comprehensive database of gene and protein interactions.
        InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
        MIST (protein-protein) - An integrated Molecular Interaction Database
        Pathways
        Signaling Pathways (FlyBase)
        Metabolic Pathways
        External Data
        Linkouts
        Genomic Location and Detailed Mapping Data
        Chromosome (arm)
        3R
        Recombination map
        3-51
        Cytogenetic map
        87A4-87A5
        Sequence location
        3R:12,007,476..12,010,434 [-]
        FlyBase Computed Cytological Location
        Cytogenetic map
        Evidence for location
        87A4-87A5
        Limits computationally determined from genome sequence between P{EP}Lk6EP886 and P{PZ}svp07842
        Experimentally Determined Cytological Location
        Cytogenetic map
        Notes
        References
        Experimentally Determined Recombination Data
        Location

        3-51

        (FlyBase, 2016)

        3-49.0

        (Comeron et al., 2012)
        Left of (cM)
        Right of (cM)
        Notes
        Stocks and Reagents
        Stocks (6)
        Genomic Clones (29)
        cDNA Clones (193)
         

        Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

        cDNA clones, fully sequenced
        BDGP DGC clones
        Other clones
        Drosophila Genomics Resource Center cDNA clones

        For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

        cDNA Clones, End Sequenced (ESTs)
        BDGP DGC clones
        Other clones
        RNAi and Array Information
        Linkouts
        DRSC - Results frm RNAi screens
        GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
        Antibody Information
        Laboratory Generated Antibodies
         
        Commercially Available Antibodies
         
        Other Information
        Relationship to Other Genes
        Source for database identify of

        Source for identity of: KLHL18 CG3571

        (Fujiyama-Nakamura et al., 2009)
        Source for database merge of

        Source for merge of: CG3571 anon-WO0118547.179

        (FlyBase, 1996-)
        Additional comments

        Source for merge of CG3571 anon-WO0118547.179 was sequence comparison ( date:051113 ).

        (FlyBase, 1996-)
        Other Comments

        dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.

        (Kiger et al., 2003)

        Area matching Drosophila EST AA536537.

        (Davies, 2001.3.15)
        Origin and Etymology
        Discoverer
        Etymology
        Identification
        External Crossreferences and Linkouts ( 49 )
        Sequence Crossreferences
        NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
        GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
        GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
        RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
        UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
        Other crossreferences
        BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
        Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
        Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
        Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
        Flygut - An atlas of the Drosophila adult midgut
        GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
        iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
        InterPro - A database of protein families, domains and functional sites
        KEGG Genes - Molecular building blocks of life in the genomic space.
        modMine - A data warehouse for the modENCODE project
        Linkouts
        BioGRID - A database of protein and genetic interactions.
        DPiM - Drosophila Protein interaction map
        DroID - A comprehensive database of gene and protein interactions.
        DRSC - Results frm RNAi screens
        FLIGHT - Cell culture data for RNAi and other high-throughput technologies
        FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
        FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
        FlyMine - An integrated database for Drosophila genomics
        InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
        MIST (protein-protein) - An integrated Molecular Interaction Database
        Synonyms and Secondary IDs (5)
        Reported As
        Symbol Synonym
        CG3571
        (Japanese National Institute of Genetics, 2012.5.21, Ni et al., 2010.12.1, Fujiyama-Nakamura et al., 2009, Liebl and Featherstone, 2008, Cao et al., 2007)
        KLHL18
        (Luck et al., 2014, Ida et al., 2013)
        anon-WO0118547.179
        dKLHL18
        (Zhou et al., 2015, Fujiyama-Nakamura et al., 2009)
        Name Synonyms
        Kelch like family member 18
        Secondary FlyBase IDs
        • FBgn0062189
        Datasets (0)
        Study focus (0)
        Experimental Role
        Project
        Project Type
        Title
        References (32)