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Gene Dmel\KLHL18

General Information
Symbol	Dmel\KLHL18	Species	D. melanogaster
Name		Annotation symbol	CG3571
Feature type	protein_coding_gene	FlyBase ID	FBgn0037978
Gene Model Status	Current	Stock availability	4 publicly available
Genomic Location
Chromosome (arm)	3R	Recombination map
Cytogenetic map	87A4-87A5	Sequence location	3R:7,833,832..7,836,152 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	This gene is referred to in FlyBase by the symbol Dmel\KLHL18 (CG3571, FBgn0037978). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: actin binding. There is experimental evidence that it is involved in the biological process: imaginal disc fusion, thorax closure. 4 alleles are reported. The phenotypes of these alleles are annotated with: trichogen cell; scutellar bristle. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: BTB/Kelch-associated; BTB/POZ; BTB/POZ fold; BTB/POZ-like; Galactose oxidase, beta-propeller; Kelch repeat type 1; Kelch-like protein, gigaxonin. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression. Peak expression observed within 00-12 hour embryonic stages, during late larval stages, during early pupal stages. Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: larval fat body. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, larval/adult central nervous system, adult female reproductive system, adult male accessory gland, larval carcass. Comments on Affy2 ProbeSet: ProbeSet 1631045_a_at completely aligns to an exonic region common to each of the 2 FlyBase-annotated transcript isoforms of KLHL18. Gene sequence location is 3R:7833832..7836152.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2011_10
FB2012_01	Sequence features HFA15496 BKN25744
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 87A4-87A5   Limits computationally determined from genome sequence between P{EP}Lk6EP886 and P{PZ}svp07842
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\KLHL18 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) KLHL18-RA FBtr0082556  NM_141886   2088   575 KLHL18-RB FBtr0082557  NM_169446   2122   538
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein KLHL18-PA   FBpp0082029   64.9   575   6.51     NP_650143   AAF54737 KLHL18-PB   FBpp0082030   60.4   538   6.61     NP_731664   AAF54738
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • BTB/POZ-like (IPR000210) Kelch repeat type 1 (IPR006652) BTB/Kelch-associated (IPR011705) BTB/POZ (IPR013069) BTB/POZ fold (IPR011333) Kelch-like protein, gigaxonin (IPR017096) Galactose oxidase, beta-propeller (IPR015916)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA392045   AA536537   AE014297 AAF54737   AE014297 AAF54738   AI238353   AI257567   AI512777   AI513659   AI516335   AI518079   AI518297   AW943602   AX094055   AY051950 AAK93374   BE975237   BF504938   BF505223   BF505235   BG632814   BI162555   BI162556   BI232264   BI234440   BI234969   BI363701   BI366002   BI633313   BP554297   BP554298   BT015287 AAT94516   CA804177   CA805253   CA806130   CA806510   CA806567   CA806716   CA806801   CA806994   CA807195   CA807462   CA807654   CO180983   CO331318   EC057177   EC072846   EC079760   GH747734   GH747763   GH750215   GH751108   GH751280   GH751729   GH751934   GH752617   GH758078   GH758084   GH759366   GH759375   GH770481   GH771867   GH772508   GH773891   GH774037   GH774380   GH774819   GH775408   GH777254   GH778054   GH778648   GH782255   GH782907   GH784681   GH786700   GH789093   GH789298   GH789684   GH790173   GH791456   GH794082   GH794518   GH795213   GH795511   GH795720   GH796520   GH797031   GH797060   GH797281   GH797460   GH798663   GH798904   GH801430   GH802696   GH802802   GH811682   GH812398   GH814895   GH814980   GH815571   GH817090   GH818291   GH818754   GH818872   GH819409   GH819763   GH820055   GH820332   GH822543   GH823145   GH824012   GH826091   GH826427   GH826887   GH828264   GH828335   GH831979   GH832850   GH835740   GH837117   GH837665   GH837739   GH838543   GH838864   GH838955   GH840180   GH841378   GH845553   GH845589   GH846021   GH846575   GH846814   GH848569   GH848850   GH854104   GH857245   GH857908   GH859240   GH862466   GH863448   GH864403   GH864540   GH865204   GH866657   GH866891   GH867733   GH868086   GH868988   GH873491   GH874332   GH874630   GH875951   GH877769   GH878733   GH879670   GH881712   GH882354   GH883693   GH884793   GH886733   GH887513   GH888168   GH889673   GH891901   GH895019   GH895534   GH895630   GH897459   GH898901   GH905686   GH905884   GH908910   GH909027   GH909656   GH913268   GH913335   GH913576   GH913697   GH913830   GH915183   GH916145   GH916633   GH919489   GH921213   GH922043   GH923879   GH925169   GH925239   GH926488   GH927415   GH929531   GH929614   GH930538   GH930844   GH930921   GH931314   GH931961   GH932028   GH933084   GH936388   GH938570   GH940387   GH940486
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9VGE5 Q9VGE6
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0037978    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0037978 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression. Peak expression observed within 00-12 hour embryonic stages, during late larval stages, during early pupal stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0037978 expression level Developmental Stage   Expression Level embryo 00-02hr    1348 embryo 02-04hr    2195 embryo 04-06hr    2545 embryo 06-08hr    2509 embryo 08-10hr    2161 embryo 10-12hr    2330 embryo 12-14hr    1267 embryo 14-16hr    1062 embryo 16-18hr    854 embryo 18-20hr    752 embryo 20-22hr    1011 embryo 22-24hr    853 larva L1    496 larva L2    536 larva L3 12hr old    482 larva L3 puffstage 1-2    1313 larva L3 puffstage 3-6    1695 larva L3 puffstage 7-9    1737 white prepupae new    1308 white prepupae 12hr    2214 white prepupae 24hr    1252 pupae 2d postWPP    1152 pupae 3d postWPP    849 pupae 4d postWPP    531 adult male 01day    648 adult male 05day    833 adult male 30day    681 adult female 01day    599 adult female 05day    807 adult female 30day    755 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (1348) embryo 02-04hr  (2195) embryo 04-06hr  (2545) embryo 06-08hr  (2509) embryo 08-10hr  (2161) embryo 10-12hr  (2330) embryo 12-14hr  (1267) embryo 14-16hr  (1062) embryo 16-18hr  (854) embryo 18-20hr  (752) embryo 20-22hr  (1011) embryo 22-24hr  (853) larva L1  (496) larva L2  (536) larva L3 12hr old  (482) larva L3 puffstage 1-2  (1313) larva L3 puffstage 3-6  (1695) larva L3 puffstage 7-9  (1737) white prepupae new  (1308) white prepupae 12hr  (2214) white prepupae 24hr  (1252) pupae 2d postWPP  (1152) pupae 3d postWPP  (849) pupae 4d postWPP  (531) adult male 01day  (648) adult male 05day  (833) adult male 30day  (681) adult female 01day  (599) adult female 05day  (807) adult female 30day  (755) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    1348 embryo 02-04hr  (2195) embryo 04-06hr  (2545) embryo 06-08hr  (2509) embryo 08-10hr  (2161) embryo 10-12hr  (2330) embryo 12-14hr    1267 embryo 14-16hr    1062 embryo 16-18hr    854 embryo 18-20hr    752 embryo 20-22hr    1011 embryo 22-24hr    853 larva L1    496 larva L2    536 larva L3 12hr old    482 larva L3 puffstage 1-2    1313 larva L3 puffstage 3-6  (1695) larva L3 puffstage 7-9  (1737) white prepupae new    1308 white prepupae 12hr  (2214) white prepupae 24hr    1252 pupae 2d postWPP    1152 pupae 3d postWPP    849 pupae 4d postWPP    531 adult male 01day    648 adult male 05day    833 adult male 30day    681 adult female 01day    599 adult female 05day    807 adult female 30day    755 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    1348 embryo 02-04hr    2195 embryo 04-06hr    2545 embryo 06-08hr    2509 embryo 08-10hr    2161 embryo 10-12hr    2330 embryo 12-14hr    1267 embryo 14-16hr    1062 embryo 16-18hr    854 embryo 18-20hr    752 embryo 20-22hr    1011 embryo 22-24hr    853 larva L1    496 larva L2    536 larva L3 12hr old    482 larva L3 puffstage 1-2    1313 larva L3 puffstage 3-6    1695 larva L3 puffstage 7-9    1737 white prepupae new    1308 white prepupae 12hr    2214 white prepupae 24hr    1252 pupae 2d postWPP    1152 pupae 3d postWPP    849 pupae 4d postWPP    531 adult male 01day    648 adult male 05day    833 adult male 30day    681 adult female 01day    599 adult female 05day    807 adult female 30day    755 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    1348 embryo 02-04hr    2195 embryo 04-06hr    2545 embryo 06-08hr    2509 embryo 08-10hr    2161 embryo 10-12hr    2330 embryo 12-14hr    1267 embryo 14-16hr    1062 embryo 16-18hr    854 embryo 18-20hr    752 embryo 20-22hr    1011 embryo 22-24hr    853 larva L1    496 larva L2    536 larva L3 12hr old    482 larva L3 puffstage 1-2    1313 larva L3 puffstage 3-6    1695 larva L3 puffstage 7-9    1737 white prepupae new    1308 white prepupae 12hr    2214 white prepupae 24hr    1252 pupae 2d postWPP    1152 pupae 3d postWPP    849 pupae 4d postWPP    531 adult male 01day    648 adult male 05day    833 adult male 30day    681 adult female 01day    599 adult female 05day    807 adult female 30day    755 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0037978 expression level Developmental Stage   Expression Level embryo 00-02hr    1348 embryo 02-04hr    2195 embryo 04-06hr    2545 embryo 06-08hr    2509 embryo 08-10hr    2161 embryo 10-12hr    2330 embryo 12-14hr    1267 embryo 14-16hr    1062 embryo 16-18hr    854 embryo 18-20hr    752 embryo 20-22hr    1011 embryo 22-24hr    853 larva L1    496 larva L2    536 larva L3 12hr old    482 larva L3 puffstage 1-2    1313 larva L3 puffstage 3-6    1695 larva L3 puffstage 7-9    1737 white prepupae new    1308 white prepupae 12hr    2214 white prepupae 24hr    1252 pupae 2d postWPP    1152 pupae 3d postWPP    849 pupae 4d postWPP    531 adult male 01day    648 adult male 05day    833 adult male 30day    681 adult female 01day    599 adult female 05day    807 adult female 30day    755 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (1348) embryo 02-04hr  (2195) embryo 04-06hr  (2545) embryo 06-08hr  (2509) embryo 08-10hr  (2161) embryo 10-12hr  (2330) embryo 12-14hr  (1267) embryo 14-16hr  (1062) embryo 16-18hr  (854) embryo 18-20hr  (752) embryo 20-22hr  (1011) embryo 22-24hr  (853) larva L1  (496) larva L2  (536) larva L3 12hr old  (482) larva L3 puffstage 1-2  (1313) larva L3 puffstage 3-6  (1695) larva L3 puffstage 7-9  (1737) white prepupae new  (1308) white prepupae 12hr  (2214) white prepupae 24hr  (1252) pupae 2d postWPP  (1152) pupae 3d postWPP  (849) pupae 4d postWPP  (531) adult male 01day  (648) adult male 05day  (833) adult male 30day  (681) adult female 01day  (599) adult female 05day  (807) adult female 30day  (755) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    1348 embryo 02-04hr  2195 embryo 04-06hr  (2545) embryo 06-08hr  (2509) embryo 08-10hr  2161 embryo 10-12hr  2330 embryo 12-14hr    1267 embryo 14-16hr    1062 embryo 16-18hr    854 embryo 18-20hr    752 embryo 20-22hr    1011 embryo 22-24hr    853 larva L1    496 larva L2    536 larva L3 12hr old    482 larva L3 puffstage 1-2    1313 larva L3 puffstage 3-6  1695 larva L3 puffstage 7-9  1737 white prepupae new    1308 white prepupae 12hr  2214 white prepupae 24hr    1252 pupae 2d postWPP    1152 pupae 3d postWPP    849 pupae 4d postWPP    531 adult male 01day    648 adult male 05day    833 adult male 30day    681 adult female 01day    599 adult female 05day    807 adult female 30day    755 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    1348 embryo 02-04hr    2195 embryo 04-06hr    2545 embryo 06-08hr    2509 embryo 08-10hr    2161 embryo 10-12hr    2330 embryo 12-14hr    1267 embryo 14-16hr    1062 embryo 16-18hr    854 embryo 18-20hr    752 embryo 20-22hr    1011 embryo 22-24hr    853 larva L1    496 larva L2    536 larva L3 12hr old    482 larva L3 puffstage 1-2    1313 larva L3 puffstage 3-6    1695 larva L3 puffstage 7-9    1737 white prepupae new    1308 white prepupae 12hr    2214 white prepupae 24hr    1252 pupae 2d postWPP    1152 pupae 3d postWPP    849 pupae 4d postWPP    531 adult male 01day    648 adult male 05day    833 adult male 30day    681 adult female 01day    599 adult female 05day    807 adult female 30day    755 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    1348 embryo 02-04hr    2195 embryo 04-06hr    2545 embryo 06-08hr    2509 embryo 08-10hr    2161 embryo 10-12hr    2330 embryo 12-14hr    1267 embryo 14-16hr    1062 embryo 16-18hr    854 embryo 18-20hr    752 embryo 20-22hr    1011 embryo 22-24hr    853 larva L1    496 larva L2    536 larva L3 12hr old    482 larva L3 puffstage 1-2    1313 larva L3 puffstage 3-6    1695 larva L3 puffstage 7-9    1737 white prepupae new    1308 white prepupae 12hr    2214 white prepupae 24hr    1252 pupae 2d postWPP    1152 pupae 3d postWPP    849 pupae 4d postWPP    531 adult male 01day    648 adult male 05day    833 adult male 30day    681 adult female 01day    599 adult female 05day    807 adult female 30day    755 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0037978    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0037978 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: larval fat body. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, larval/adult central nervous system, adult female reproductive system, adult male accessory gland, larval carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0037978 expression level Tissue   Expression Level Larval Central Nervous System    162.575 Larval Midgut    63.5 Larval Hindgut    71.1 Larval Malpighian Tubules    83.2 Larval Fat Body    564.3 Larval Salivary Gland    69 Larval Trachea    82.9 Larval Carcass    153.95 Adult Head    110.9 Adult Eye    97.925 Adult Brain    233 Adult Thoracic-Abdominal Ganglion    282 Adult Crop    51.7 Adult Midgut    65.3 Adult Hindgut    50.3 Adult Malpighian Tubules    92.7 Adult Fat Body    95.5 Adult Salivary Gland    71.7 Adult Heart    81.025 Adult VirginFemale Spermatheca    100.8 Adult InseminatedFemale Spermatheca    99.9 Adult Ovary    101.9 Adult Testis    86.1 Adult Male Accessory Gland    101.7 Adult Carcass    78.4 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    162.575 Larval Midgut    63.5 Larval Hindgut    71.1 Larval Malpighian Tubules    83.2 Larval Fat Body  (564.3) Larval Salivary Gland    69 Larval Trachea    82.9 Larval Carcass    153.95 Adult Head    110.9 Adult Eye    97.925 Adult Brain    233 Adult Thoracic-Abdominal Ganglion    282 Adult Crop    51.7 Adult Midgut    65.3 Adult Hindgut    50.3 Adult Malpighian Tubules    92.7 Adult Fat Body    95.5 Adult Salivary Gland    71.7 Adult Heart    81.025 Adult VirginFemale Spermatheca    100.8 Adult InseminatedFemale Spermatheca    99.9 Adult Ovary    101.9 Adult Testis    86.1 Adult Male Accessory Gland    101.7 Adult Carcass    78.4 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    162.575 Larval Midgut    63.5 Larval Hindgut    71.1 Larval Malpighian Tubules    83.2 Larval Fat Body    564.3 Larval Salivary Gland    69 Larval Trachea    82.9 Larval Carcass    153.95 Adult Head    110.9 Adult Eye    97.925 Adult Brain    233 Adult Thoracic-Abdominal Ganglion    282 Adult Crop    51.7 Adult Midgut    65.3 Adult Hindgut    50.3 Adult Malpighian Tubules    92.7 Adult Fat Body    95.5 Adult Salivary Gland    71.7 Adult Heart    81.025 Adult VirginFemale Spermatheca    100.8 Adult InseminatedFemale Spermatheca    99.9 Adult Ovary    101.9 Adult Testis    86.1 Adult Male Accessory Gland    101.7 Adult Carcass    78.4 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    162.575 Larval Midgut    63.5 Larval Hindgut    71.1 Larval Malpighian Tubules    83.2 Larval Fat Body    564.3 Larval Salivary Gland    69 Larval Trachea    82.9 Larval Carcass    153.95 Adult Head    110.9 Adult Eye    97.925 Adult Brain    233 Adult Thoracic-Abdominal Ganglion    282 Adult Crop    51.7 Adult Midgut    65.3 Adult Hindgut    50.3 Adult Malpighian Tubules    92.7 Adult Fat Body    95.5 Adult Salivary Gland    71.7 Adult Heart    81.025 Adult VirginFemale Spermatheca    100.8 Adult InseminatedFemale Spermatheca    99.9 Adult Ovary    101.9 Adult Testis    86.1 Adult Male Accessory Gland    101.7 Adult Carcass    78.4 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0037978 expression level Tissue   Expression Level Larval Central Nervous System    162.575 Larval Midgut    63.5 Larval Hindgut    71.1 Larval Malpighian Tubules    83.2 Larval Fat Body    564.3 Larval Salivary Gland    69 Larval Trachea    82.9 Larval Carcass    153.95 Adult Head    110.9 Adult Eye    97.925 Adult Brain    233 Adult Thoracic-Abdominal Ganglion    282 Adult Crop    51.7 Adult Midgut    65.3 Adult Hindgut    50.3 Adult Malpighian Tubules    92.7 Adult Fat Body    95.5 Adult Salivary Gland    71.7 Adult Heart    81.025 Adult VirginFemale Spermatheca    100.8 Adult InseminatedFemale Spermatheca    99.9 Adult Ovary    101.9 Adult Testis    86.1 Adult Male Accessory Gland    101.7 Adult Carcass    78.4 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    162.575 Larval Midgut    63.5 Larval Hindgut    71.1 Larval Malpighian Tubules    83.2 Larval Fat Body  564.3 Larval Salivary Gland    69 Larval Trachea    82.9 Larval Carcass    153.95 Adult Head    110.9 Adult Eye    97.925 Adult Brain    233 Adult Thoracic-Abdominal Ganglion    282 Adult Crop    51.7 Adult Midgut    65.3 Adult Hindgut    50.3 Adult Malpighian Tubules    92.7 Adult Fat Body    95.5 Adult Salivary Gland    71.7 Adult Heart    81.025 Adult VirginFemale Spermatheca    100.8 Adult InseminatedFemale Spermatheca    99.9 Adult Ovary    101.9 Adult Testis    86.1 Adult Male Accessory Gland    101.7 Adult Carcass    78.4 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    162.575 Larval Midgut    63.5 Larval Hindgut    71.1 Larval Malpighian Tubules    83.2 Larval Fat Body    564.3 Larval Salivary Gland    69 Larval Trachea    82.9 Larval Carcass    153.95 Adult Head    110.9 Adult Eye    97.925 Adult Brain    233 Adult Thoracic-Abdominal Ganglion    282 Adult Crop    51.7 Adult Midgut    65.3 Adult Hindgut    50.3 Adult Malpighian Tubules    92.7 Adult Fat Body    95.5 Adult Salivary Gland    71.7 Adult Heart    81.025 Adult VirginFemale Spermatheca    100.8 Adult InseminatedFemale Spermatheca    99.9 Adult Ovary    101.9 Adult Testis    86.1 Adult Male Accessory Gland    101.7 Adult Carcass    78.4 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    162.575 Larval Midgut    63.5 Larval Hindgut    71.1 Larval Malpighian Tubules    83.2 Larval Fat Body    564.3 Larval Salivary Gland    69 Larval Trachea    82.9 Larval Carcass    153.95 Adult Head    110.9 Adult Eye    97.925 Adult Brain    233 Adult Thoracic-Abdominal Ganglion    282 Adult Crop    51.7 Adult Midgut    65.3 Adult Hindgut    50.3 Adult Malpighian Tubules    92.7 Adult Fat Body    95.5 Adult Salivary Gland    71.7 Adult Heart    81.025 Adult VirginFemale Spermatheca    100.8 Adult InseminatedFemale Spermatheca    99.9 Adult Ovary    101.9 Adult Testis    86.1 Adult Male Accessory Gland    101.7 Adult Carcass    78.4 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    110.9   NA  Eye    97.925   NA  Brain    233   162.575  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    282   NA  Crop    51.7   63.5  Midgut    65.3   71.1  Hindgut    50.3   83.2  Malpighian Tubules    92.7   564.3  Fat Body    95.5   69  Salivary Gland    71.7   NA  Heart    81.025   82.9  Trachea    NA   NA  VirginFemale Spermatheca    100.8   NA  InseminatedFemale Spermatheca    99.9   NA  Ovary    101.9   NA  Testis    86.1   NA  Male Accessory Gland    101.7   153.95  Carcass    78.4 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_30
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0037978 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG3571-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable, with Scer\GAL4pnr-MD237 KLHL18GD11014 Other Phenotypes Allele visible, with Scer\GAL4pnr-MD237 KLHL18GD11014 KLHL18GS10310 KLHL18GS15802 KLHL18Scer\UAS.cFNa Phenotype manifest in Allele adult external thorax | dorsal, with Scer\GAL4pnr-MD237 KLHL18GS15802 KLHL18GS10310 KLHL18Scer\UAS.cFNa scutellar bristle, with Scer\GAL4pnr-MD237 KLHL18GS15802 KLHL18GS10310 KLHL18Scer\UAS.cFNa trichogen cell, with Scer\GAL4pnr-MD237 KLHL18GD11014
Classical Alleles ( 2 )
For All Classical Alleles Show
Allele of KLHL18 Class Mutagen Stocks Known lesion KLHL18GS10310 1 -- KLHL18GS15802 1 --
Alleles Carried on Transgenic Constructs ( 2 )
For All Alleles Carried on Transgenic Constructs Show
Allele of KLHL18 Class Mutagen Stocks Known lesion KLHL18GD11014 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes KLHL18Scer\UAS.cFNa in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3R)Exel6162 (Ryder, 2004.4.26) Df(3R)Exel7312 (Ryder, 2004.4.26) Df(3R)Exel8155 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{UAS-KLHL18.FN} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions P{SUPor-P}KG06469 NA insertion of mobile activating element P{GSV6}KLHL18GS10310 NA P{GSV6}KLHL18GS15802 NA
Gene Ontology: Function, Process & Cellular Component ( 3 unique terms )
Terms Based on Experimental Evidence ( 2 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
imaginal disc fusion, thorax closure inferred from mutant phenotype (Fujiyama-Nakamura et al., 2009)
Cellular Component
CV term Evidence References
Cul3-RING ubiquitin ligase complex inferred from genetic interaction with Cul-3 (Fujiyama-Nakamura et al., 2009) inferred from physical interaction with Cul-3 (Fujiyama-Nakamura et al., 2009)
Terms Based on Predictions or Assertions ( 1 term )
Molecular Function
CV term Evidence References
actin binding inferred from sequence or structural similarity (Goldstein and Gunawardena, 2000)
Biological Process ( 0 terms)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions KLHL18 allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 66575 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0037978 DroID - A comprehensive database of gene and protein interactions. • FBgn0037978 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 41458
Orthologs
Genome-wide drosophilid orthologs	Dana\GF17752 Dere\GG17168 Dgri\GH12392 Dmoj\GI24060 Dper\GL21584 Dpse\GA17529 Dsec\GM26048 Dsim\GD20611 Dvir\GJ23685 Dwil\GK11665 Dyak\GE24559
Curated drosophilid orthologs	Dpse\GA17529
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AGAP011142-PA Anopheles gambiae (mosquito) XP_001950327.1 Acyrthosiphon pisum (pea aphid) At1g67480.1 Arabidopsis thaliana (wall cress) 58921 Branchiostoma floridae (lancelet) XP_001896720.1 Brugia malayi (roundworm nematode) ENSBTAP00000008633 Bos taurus (bovine) CN28823 Caenorhabditis brenneri (small nematode) CBP11702 Caenorhabditis briggsae (nematode) CE29825 Caenorhabditis elegans (worm) ENSCAFP00000019632 Canis familiaris (dog) ENSCINP00000013326 Ciona intestinalis (sea squirt) JA06774 Caenorhabditis japonica (nematode) CPIJ013035 Culex pipens (mosquito) ENSCPOP00000001969 Cavia porcellus (guinea pig) 151000 Capitella spl (polychaete worm) 305899 Daphnia pulex (daphnia) ENSDARP00000025821 Danio rerio (zebra fish) ENSECAP00000022119 Equus caballus (horse) ENSGALP00000008957 Gallus gallus (chicken) ENSP00000232766 Homo sapiens (human) ISCW007741-PA Ixodes scapularis (deer tick) 177864 Lottia gigantea (owl limpet) ENSMODP00000017603 Monodelphis domestica (gray opossum) ENSMMUP00000008505 Macaca mulatta (rhesus monkey) ENSMUSP00000107565 Mus musculus (house mouse) 158213 Nematostella vectensis (starlet anemone) XP_001599274.1 Nasonia vitripennis (wasp) ENSORLP00000009587 Oryzias latipes (japanese killifish) PF13_0238 Plasmodium falciparum (protozoal parasite) PHUM005117-PA Pediculus humanus (human body louse) PP23532 Pristionchus pacificus (nematode) ENSPPYP00000015572 Pongo pygmaeus (orangutan) ENSPTRP00000025637 Pan troglodytes (chimpanzee) PVX_083080 Plasmodium vivax (protozoal parasite) ENSRNOP00000052988 Rattus norvegicus (norway rat) XP_783729.1 Strongylocentrotus purpuratus (purple sea urchin) 31047 Trichoplax adhaerens (metazoa) XP_972811.2 Tribolium castaneum (red flour beetle) ENSTNIP00000005642 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000021417 Takifugu rubripes (pufferfish Takifugu) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV18288 ISCW007741 FBgn0241671 FBgn0213676 FBgn0210782 FBgn0192078 FBgn0180903 JGI_V11_305899 FBgn0077540 FBgn0159177 FBgn0146783 FBgn0132717 FBgn0119871 FBgn0109395 FBgn0094770 CPIJ013035 ACYPI005528 AGAP011142 PHUM449490 GLEAN_06676
Stocks & Reagents
Stocks Listed in FlyBase ( 4 )
Kyoto	202465 y1 w67c23; P{GSV6}KLHL18GS10310/TM3, Sb1 Ser1 206359 y1 w67c23; P{GSV6}KLHL18GS15802/TM3, Sb1 Ser1
VDRC	v43777 w1118; P{GD11014}v43777 v43778 w1118; P{GD11014}v43778/CyO
Genomic Clones ( 2 )
	BACR06O05 BACR48E12 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 193 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GH14381 LD42169
Other clones	DPiM_GH14381
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT07082 AT07407 AT07419 LD12409 LD17187 LD37491 LD37770 LD44805 LD45872 LP05971 RE28308 RE30139 RE30750 RE48625 RE51425 SD27374
Other clones	32897 bs40d04 CK01.2A.E8 CK01.20B.B4 EC13302 EK299051 ESG012a.E21_E02 ESG013d.E21_A01 ESG014a.E21_A05 ESG014d.E21_A05 ESG015a.E21_C11 ESG015d.E21.1_E01 ESG016c.E21_H07 ESG018a.E21_C09 ESG018d.E21_E04 ESG0112b.B21_G09 ESG0117b.B21_B12 FGM229B02 RE01844 RP003000740 RP003009792 RP003040002 RP003066670 RP003078372 RP003082283 RP003094564 RP003099931 RP003104183 RP003105335 RP003105344 RP003111730 RP003111887 RP003113480 RP003115360 RP003115863 RP003123564 RP003128314 RP003134122 RP003142157 RP003143375 RP003144159 RP003149658 RP003155603 RP003156171 RP003159451 RP003160197 RP003160202 RP003169664 RP003177351 RP003180835 RP003181739 RP003195170 RP003197645 RP003205847 RP003207022 RP003210712 RP003211133 RP003211428 RP003213623 RP003214505 RP003215592 RP003217801 RP003220120 RP003220622 RP003222116 RP003222564 RP003224704 RP003227291 RP003231961 RP003232364 RP003233331 RP003233810 RP003245037 RP003247260 RP003253001 RP003253069 RP003254578 RP003264184 RP003272386 RP003280016 RP003289500 RP003297209 RP003298766 RP003304208 RP003312209 RP003312987 RP003314706 RP003316766 RP003317456 RP003318152 RP003320916 RP003323745 RP003331344 RP003332572 RP003337169 RP003338227 RP003341582 RP003346672 RP003358100 RP003365907 RP003368022 RP003384504 RP003391781 RP003394445 RP003397757 RP003404462 RP003409146 RP003425568 RP003439017 RP003443388 RP003443471 RP003446015 RP003447010 RP003455914 RP003464537 RP003464801 RP003467790 RP003468303 RP003469552 RP003471537 RP003471828 RP003474519 RP003482687 RP003484083 RP003484700 RP003484914 RP003485510 RP003490254 RP003492414 RP003494087 RP003494799 RP003498334 RP003499296 RP003505535 RP003515728 RP003521436 RP003522212 RP003526260 RP003530112 RP003543735 RP003544821 RP003546012 RP003547043 RP003550736 RP003554815 RP003561121 RP003569221 RP003572960 RP003584855 RP003587672 RP003588940 RP003589948 RP003591492 RP003597376 RP003603350 RP003605349 RP003609121 RP003612374 RP003613678 RP003623248 RP003624898 RP003632109 RP003634430 RP003638509 RP003642888 RP003643585 RP003647000 RP003648387 RP003657565 RP003661256 RP003667352 RP003669355 RP003670735 RP003673041
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0037978 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 41458
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: KLHL18 CG3571 (Fujiyama-Nakamura et al., 2009)
Source for database merge of	Source for merge of: CG3571 anon-WO0118547.179 (FlyBase, 1996-)
Additional comments	Source for merge of CG3571 anon-WO0118547.179 was sequence comparison (date:051113). (FlyBase, 1996-)
Other Comments
	dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology. (Kiger et al., 2003) Area matching Drosophila EST AA536537. (Davies, 2001.3.15)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_141886 NM_169446 RefSeq (Proteins) • NP_650143 NP_731664 DDBJ / EMBL / GenBank • AA536537 AAF54737 AAF54738 AAK93374 AAT94516 AI238353 AI516335 AW943602 AX094055 AY051950 BG632814 BT015287 Entrez Gene - A searchable database of RefSeq genes. • 41458 UniProtKB/TrEMBL • Q9VGE5 Q9VGE6
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • BTB/POZ-like (IPR000210) Kelch repeat type 1 (IPR006652) BTB/Kelch-associated (IPR011705) BTB/POZ (IPR013069) BTB/POZ fold (IPR011333) Kelch-like protein, gigaxonin (IPR017096) Galactose oxidase, beta-propeller (IPR015916)
Linkouts
	BioGRID - A database of protein and genetic interactions • 66575 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0037978 DroID - A comprehensive database of gene and protein interactions. • FBgn0037978 DRSC - Results from RNAi screens. • FBgn0037978 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0037978 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG3571-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0037978 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 41458 InParanoid A subset of ortholog calls from InParanoid. • AGAP011142-PA Anopheles gambiae (mosquito) XP_001950327.1 Acyrthosiphon pisum (pea aphid) At1g67480.1 Arabidopsis thaliana (wall cress) 58921 Branchiostoma floridae (lancelet) XP_001896720.1 Brugia malayi (roundworm nematode) ENSBTAP00000008633 Bos taurus (bovine) CN28823 Caenorhabditis brenneri (small nematode) CBP11702 Caenorhabditis briggsae (nematode) CE29825 Caenorhabditis elegans (worm) ENSCAFP00000019632 Canis familiaris (dog) ENSCINP00000013326 Ciona intestinalis (sea squirt) JA06774 Caenorhabditis japonica (nematode) CPIJ013035 Culex pipens (mosquito) ENSCPOP00000001969 Cavia porcellus (guinea pig) 151000 Capitella spl (polychaete worm) 305899 Daphnia pulex (daphnia) ENSDARP00000025821 Danio rerio (zebra fish) ENSECAP00000022119 Equus caballus (horse) ENSGALP00000008957 Gallus gallus (chicken) ENSP00000232766 Homo sapiens (human) ISCW007741-PA Ixodes scapularis (deer tick) 177864 Lottia gigantea (owl limpet) ENSMODP00000017603 Monodelphis domestica (gray opossum) ENSMMUP00000008505 Macaca mulatta (rhesus monkey) ENSMUSP00000107565 Mus musculus (house mouse) 158213 Nematostella vectensis (starlet anemone) XP_001599274.1 Nasonia vitripennis (wasp) ENSORLP00000009587 Oryzias latipes (japanese killifish) PF13_0238 Plasmodium falciparum (protozoal parasite) PHUM005117-PA Pediculus humanus (human body louse) PP23532 Pristionchus pacificus (nematode) ENSPPYP00000015572 Pongo pygmaeus (orangutan) ENSPTRP00000025637 Pan troglodytes (chimpanzee) PVX_083080 Plasmodium vivax (protozoal parasite) ENSRNOP00000052988 Rattus norvegicus (norway rat) XP_783729.1 Strongylocentrotus purpuratus (purple sea urchin) 31047 Trichoplax adhaerens (metazoa) XP_972811.2 Tribolium castaneum (red flour beetle) ENSTNIP00000005642 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000021417 Takifugu rubripes (pufferfish Takifugu) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 41458 modMine - Data generated by the modENCODE project. • FBgn0037978 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV18288 ISCW007741 FBgn0241671 FBgn0213676 FBgn0210782 FBgn0192078 FBgn0180903 JGI_V11_305899 FBgn0077540 FBgn0159177 FBgn0146783 FBgn0132717 FBgn0119871 FBgn0109395 FBgn0094770 CPIJ013035 ACYPI005528 AGAP011142 PHUM449490 GLEAN_06676
Synonyms & Secondary IDs ( 4 )
Reported As
Symbol Synonym	anon-WO0118547.179   CG3571 (Fujiyama-Nakamura et al., 2009, Cao et al., 2007) dKLHL18 (Fujiyama-Nakamura et al., 2009) KLHL18
Name Synonym
Secondary FlyBase IDs
	FBgn0062189
References ( 17 )
Research paper	Fujiyama-Nakamura et al., 2009, Genes Cells 14(8): 965--973 BTB protein, dKLHL18/CG3571, serves as an adaptor subunit for a dCul3 ubiquitin ligase complex. [FBrf0208555] Cao et al., 2007, J. Cell Biol. 176(6): 843--852 Fork head controls the timing and tissue selectivity of steroid-induced developmental cell death. [FBrf0193919]
Supplementary material	The modENCODE Consortium, 2010, Science 330(6012): DataS14: Gene co-expression clusters. [FBrf0213979] Mummery-Widmer et al., 2009, Nature 458(7241): Supplementary Table 2 - Genome-wide bristle screen results. [FBrf0214518] Giot et al., 2003, Science 302(5651): Tables S1 to S7. [FBrf0166452] Kiger et al., 2003, J. Biol. 2(4): Additional data file 1: The gene identity and primer sequences for dsRNAs used in the RNAi screens. [FBrf0174231] Goldstein and Gunawardena, 2000, J. Cell Biol. 150(2): Table S2. Identified cytoskeletal protein coding genes in Drosophila. [FBrf0132100]
Personal communication to FlyBase	Dickson et al., 2007.7.18, RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0200327] Ryder, 2004.4.26, Exelixis CG deletion data. Exelixis CG deletion data. [FBrf0184335]
FlyBase analysis	FlyBase, 1996-, FlyBase inference based on genome sequence analysis. FlyBase inference based on genome sequence analysis. [FBrf0104946] FlyBase, 1992-, FlyBase curation FlyBase curation. [FBrf0105495]
Patent	Davies et al., 2001, World Patent 0118547: Essential genes and assays relating thereto. [FBrf0199103]
DNA/RNA sequence record	Davies, 2001.3.15, GenBank/EMBL/DDBJ: AX094055 Sequence 179 from Patent WO0118547. [FBrf0149867]
Computer file	Gene Disruption Project members, 2001-, [title not yet available] [title not yet available] [FBrf0132177] BDGP Project Members, 2000-, Berkeley Drosophila Genome Project. Berkeley Drosophila Genome Project. [FBrf0125078]
Automatic genome annotation	FamiliarityBreedsContempt, 1999.11, [Annotations performed at the Celera Jamboreee.] [Annotations performed at the Celera Jamboreee.] [FBrf0126705]
Curated genome annotation	Goldstein, 1999.11, [Annotations performed at the Celera Jamboreee.] [Annotations performed at the Celera Jamboreee.] [FBrf0126668]