FB2020_06, released Dec 22, 2020

Gene: Dmel\ATP8B

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General Information
Symbol
Dmel\ATP8B
Species
D. melanogaster
Name
ATPase 8B
Annotation Symbol
CG14741
Feature Type
protein_coding_gene
FlyBase ID
FBgn0037989
Gene Model Status
Current
Stock Availability
9 publicly available
Gene Snapshot
ATPase 8B (ATP8B) encodes a phospholipid flippase involved in olfaction. [Date last reviewed: 2019-09-12]
Other Summaries
Also Known As

dATP8B

Key Links
Genomic Location
Cytogenetic map
87A7-87A7
Sequence location
3R:12,068,375..12,090,612 [-]
Recombination map

3-51

RefSeq locus
NT_033777 REGION:12068375..12090612
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (12 terms)
Molecular Function (3 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
enables ATP binding
inferred from electronic annotation with InterPro:IPR006539
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
enables ATPase-coupled intramembrane lipid transporter activity
inferred from biological aspect of ancestor with PANTHER:PTN000642368
(assigned by GO_Central )
(Gaudet et al., 2011)
inferred from sequence or structural similarity with SGD:S000000024
(Tanaka et al., 2011)
enables magnesium ion binding
inferred from electronic annotation with InterPro:IPR006539
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
Biological Process (4 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
involved_in detection of chemical stimulus involved in sensory perception of smell
inferred from mutant phenotype
(Liu et al., 2014)
involved_in regulation of protein localization
inferred from mutant phenotype
(Ha et al., 2014)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
involved_in Golgi organization
inferred from biological aspect of ancestor with PANTHER:PTN001184364
(assigned by GO_Central )
(Gaudet et al., 2011)
involved_in phospholipid translocation
inferred from sequence or structural similarity with SGD:S000000024
(Tanaka et al., 2011)
inferred from biological aspect of ancestor with PANTHER:PTN000642368
(assigned by GO_Central )
(Gaudet et al., 2011)
Cellular Component (5 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
located_in cilium
inferred from direct assay
(Ha et al., 2014)
located_in sensory dendrite
inferred from direct assay
(Ha et al., 2014, Liu et al., 2014)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
located_in integral component of membrane
inferred from electronic annotation with InterPro:IPR001757, InterPro:IPR006539
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
inferred from sequence model
(Tanaka et al., 2011)
located_in plasma membrane
inferred from biological aspect of ancestor with PANTHER:PTN000642368
(assigned by GO_Central )
(Gaudet et al., 2011)
located_in trans-Golgi network
inferred from biological aspect of ancestor with PANTHER:PTN001943259
(assigned by GO_Central )
(Gaudet et al., 2011)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Gene Group (FlyBase)
PHOSPHOLIPID TRANSPORTING ATPASES -
The phospholipid transporting type IV P-ATPases are flippases that translocate phospholipids against concentration gradient from one side of a membrane to the other. This lipid shuttling forms new membrane structures, in particular vesicles. (Adapted from PMID:18439418 and PMID:26240149).
Gene Model and Products
Number of Transcripts
7
Number of Unique Polypeptides
7

Please see the JBrowse view of Dmel\ATP8B for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.49

Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
ATP8B-RB
FBtr0300351
NM_169450
6697
1726
ATP8B-RC
FBtr0307015
NM_001260138
6500
1547
ATP8B-RD
FBtr0307016
NM_001260139
6007
1496
ATP8B-RF
FBtr0339643
NM_001300365
5810
1317
ATP8B-RG
FBtr0339644
NM_001300366
6245
1462
ATP8B-RH
FBtr0339645
NM_001260140
6458
1533
ATP8B-RI
FBtr0339646
NM_001300367
6203
1448
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
ATP8B-PB
FBpp0289580
193.4
1726
7.67
NP_731669
AAF54749
ATP8B-PC
FBpp0297858
173.3
1547
7.41
NP_001247067
AFH06385
ATP8B-PD
FBpp0297859
168.2
1496
6.62
NP_001247068
AFH06386
ATP8B-PF
FBpp0308705
148.2
1317
6.38
NP_001287294
AHN57293
ATP8B-PG
FBpp0308706
163.5
1462
6.88
NP_001287295
AHN57294
ATP8B-PH
FBpp0308707
171.7
1533
7.41
NP_001247069
AFH06387
ATP8B-PI
FBpp0308708
161.9
1448
6.88
NP_001287296
AHN57295
Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\ATP8B using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
microinjection
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
antenna

Comment: transcripts lacking variable exon enriched in antenna

(Ha et al., 2014)
embryonic stage -- adult stage
(Ha et al., 2014)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
sensillum basiconicum of antennal segment 3
(Liu et al., 2014)
sensillum trichodeum of antennal segment 3
(Liu et al., 2014)
adult olfactory receptor neuron | subset
• dendrite
(Liu et al., 2014)
adult olfactory receptor neuron Or67d
(Ha et al., 2014)
adult olfactory receptor neuron

Comment: expressed in all Orco-expressing olfactory neurons

(Ha et al., 2014)
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
• membrane
(Aradska et al., 2015)
Additional Descriptive Data

ATP8B-protein is expressed in the outer dendrites of Orco-expressing adult olfactory receptor neurons. These labeled dendrites are located in the shafts of both basiconic and trichoid sensilla.

(Liu et al., 2014)
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in cilium
inferred from direct assay
(Ha et al., 2014)
located_in sensory dendrite
inferred from direct assay
(Ha et al., 2014, Liu et al., 2014)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\ATP8B in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 11 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 8 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of ATP8B
Transgenic constructs containing regulatory region of ATP8B
Deletions and Duplications ( 3 )
Phenotypes
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (34)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\ATP8B2
12 of 15
Yes
Yes
Hsap\ATP8B4
9 of 15
No
Yes
Hsap\ATP8B1
8 of 15
No
Yes
Hsap\ATP8B3
6 of 15
No
Yes
Hsap\ATP11A
4 of 15
No
No
Hsap\ATP11C
4 of 15
No
No
Hsap\ATP8A1
3 of 15
No
No
Hsap\ATP8A2
3 of 15
No
No
Hsap\ATP10B
3 of 15
No
No
Hsap\ATP10D
3 of 15
No
No
Hsap\ATP11B
3 of 15
No
No
1  
Hsap\ATP9A
2 of 15
No
No
Hsap\ATP10A
2 of 15
No
No
1  
Hsap\ATP1A1
1 of 15
No
No
Hsap\ATP1A2
1 of 15
No
No
Hsap\ATP1A3
1 of 15
No
No
1  
Hsap\ATP1A4
1 of 15
No
No
Hsap\ATP2A1
1 of 15
No
No
Hsap\ATP2A2
1 of 15
No
No
Hsap\ATP2A3
1 of 15
No
No
Hsap\ATP2B1
1 of 15
No
No
Hsap\ATP2B2
1 of 15
No
No
1  
Hsap\ATP2B3
1 of 15
No
No
Hsap\ATP2B4
1 of 15
No
No
1  
Hsap\ATP2C1
1 of 15
No
No
Hsap\ATP2C2
1 of 15
No
No
Hsap\ATP4A
1 of 15
No
No
Hsap\ATP9B
1 of 15
No
No
Hsap\ATP12A
1 of 15
No
No
Hsap\ATP13A1
1 of 15
No
No
Hsap\ATP13A2
1 of 15
No
No
Hsap\ATP13A3
1 of 15
No
No
Hsap\ATP13A4
1 of 15
No
No
Hsap\ATP13A5
1 of 15
No
No
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (35)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Atp8b2
11 of 15
Yes
Yes
Mmus\Atp8b4
9 of 15
No
Yes
Mmus\Atp8b5
9 of 15
No
Yes
Mmus\Atp8b1
8 of 15
No
Yes
Mmus\Atp8b3
6 of 15
No
Yes
Mmus\Atp11a
4 of 15
No
No
Mmus\Atp11c
4 of 15
No
No
Mmus\Atp8a1
3 of 15
No
No
Mmus\Atp8a2
3 of 15
No
No
Mmus\Atp10b
3 of 15
No
No
Mmus\Atp11b
3 of 15
No
No
Mmus\Atp10a
2 of 15
No
No
Mmus\Atp1a1
1 of 15
No
No
Mmus\Atp1a2
1 of 15
No
No
Mmus\Atp1a3
1 of 15
No
No
Mmus\Atp1a4
1 of 15
No
No
Mmus\Atp2a1
1 of 15
No
No
Mmus\Atp2a2
1 of 15
No
No
Mmus\Atp2a3
1 of 15
No
No
Mmus\Atp2b1
1 of 15
No
No
Mmus\Atp2b2
1 of 15
No
No
Mmus\Atp2b3
1 of 15
No
No
Mmus\Atp2b4
1 of 15
No
No
Mmus\Atp2c1
1 of 15
No
No
Mmus\Atp2c2
1 of 15
No
No
Mmus\Atp4a
1 of 15
No
No
Mmus\Atp9a
1 of 15
No
No
Mmus\Atp9b
1 of 15
No
No
Mmus\Atp10d
1 of 15
No
No
Mmus\Atp12a
1 of 15
No
No
Mmus\Atp13a1
1 of 15
No
No
Mmus\Atp13a2
1 of 15
No
No
Mmus\Atp13a3
1 of 15
No
No
Mmus\Atp13a4
1 of 15
No
No
Mmus\Atp13a5
1 of 15
No
No
Rattus norvegicus (Norway rat) (30)
Rnor\Atp8b2
9 of 13
Yes
Yes
Rnor\Atp8b1
8 of 13
No
Yes
Rnor\Atp8b3
6 of 13
No
Yes
Rnor\Atp11a
4 of 13
No
No
Rnor\Atp11c
4 of 13
No
No
Rnor\Atp8a2
3 of 13
No
No
Rnor\Atp8b5p
3 of 13
No
Yes
Rnor\Atp10b
3 of 13
No
No
Rnor\Atp10d
3 of 13
No
No
Rnor\Atp8b4
2 of 13
No
Yes
Rnor\Atp1a1
1 of 13
No
No
1  
Rnor\Atp1a2
1 of 13
No
No
Rnor\Atp1a3
1 of 13
No
No
Rnor\Atp1a4
1 of 13
No
No
Rnor\Atp2a2
1 of 13
No
No
Rnor\Atp2b4
1 of 13
No
No
Rnor\Atp2c1
1 of 13
No
No
Rnor\Atp2c2
1 of 13
No
No
Rnor\Atp4a
1 of 13
No
No
Rnor\Atp8a1
1 of 13
No
No
Rnor\Atp9a
1 of 13
No
No
Rnor\Atp9b
1 of 13
No
No
Rnor\Atp10a
1 of 13
No
No
Rnor\Atp11b
1 of 13
No
No
Rnor\Atp12a
1 of 13
No
No
Rnor\Atp13a1
1 of 13
No
No
Rnor\Atp13a2
1 of 13
No
No
Rnor\Atp13a3
1 of 13
No
No
Rnor\Atp13a4
1 of 13
No
No
Rnor\Atp13a5
1 of 13
No
No
Xenopus tropicalis (Western clawed frog) (31)
Xtro\atp8b1
8 of 12
Yes
Yes
Xtro\LOC100490503
6 of 12
No
Yes
Xtro\atp8b3
5 of 12
No
Yes
Xtro\atp8b4
5 of 12
No
Yes
Xtro\atp10d
3 of 12
No
No
Xtro\atp11a
3 of 12
No
No
Xtro\atp11c
3 of 12
No
No
Xtro\atp8a1
2 of 12
No
No
Xtro\atp9a
2 of 12
No
No
Xtro\atp10a
2 of 12
No
No
Xtro\atp11b
2 of 12
No
No
Xtro\atp1a1
1 of 12
No
No
Xtro\atp1a2
1 of 12
No
No
Xtro\atp1a3
1 of 12
No
No
Xtro\atp2a1
1 of 12
No
No
Xtro\atp2a2
1 of 12
No
No
Xtro\atp2b2
1 of 12
No
No
Xtro\atp2c1
1 of 12
No
No
Xtro\atp2c2
1 of 12
No
No
Xtro\atp4a
1 of 12
No
No
Xtro\atp8a2
1 of 12
No
No
Xtro\atp9b
1 of 12
No
No
Xtro\atp10b
1 of 12
No
No
Xtro\atp12a-like
1 of 12
No
No
Xtro\atp13a1
1 of 12
No
No
Xtro\atp13a3
1 of 12
No
No
Xtro\atp13a4
1 of 12
No
No
Xtro\atp13a5
1 of 12
No
No
Xtro\atp13a-like
1 of 12
No
No
Xtro\LOC100488346
1 of 12
No
No
Xtro\LOC101730879
1 of 12
No
Yes
Danio rerio (Zebrafish) (39)
Drer\atp8b1
8 of 15
Yes
Yes
Drer\atp8b4
7 of 15
No
Yes
Drer\atp8b5b
7 of 15
No
Yes
Drer\atp8b3
6 of 15
No
Yes
Drer\atp8b5a
6 of 15
No
Yes
Drer\atp11a
4 of 15
No
No
Drer\atp11c
4 of 15
No
No
Drer\atp8a1
3 of 15
No
No
Drer\atp8a2
3 of 15
No
No
Drer\atp8b2
3 of 15
No
Yes
Drer\atp10b
3 of 15
No
No
Drer\atp10d
3 of 15
No
No
Drer\atp9a
2 of 15
No
Yes
Drer\atp10a
2 of 15
No
No
Drer\atp1a1a.1
1 of 15
No
No
Drer\atp1a1a.2
1 of 15
No
No
Drer\atp1a1a.3
1 of 15
No
No
Drer\atp1a1a.4
1 of 15
No
No
Drer\atp1a1a.5
1 of 15
No
No
Drer\atp1a1b
1 of 15
No
No
Drer\atp1a2a
1 of 15
No
No
Drer\atp1a3a
1 of 15
No
No
Drer\atp2a1
1 of 15
No
No
Drer\atp2a1l
1 of 15
No
No
Drer\atp2a2a
1 of 15
No
No
Drer\atp2a2b
1 of 15
No
No
Drer\atp2a3
1 of 15
No
No
Drer\atp2b1a
1 of 15
No
No
Drer\atp2b1b
1 of 15
No
No
Drer\atp2b2
1 of 15
No
No
Drer\atp2b3a
1 of 15
No
No
Drer\atp2b3b
1 of 15
No
No
Drer\atp2c1
1 of 15
No
No
Drer\atp9b
1 of 15
No
No
Drer\atp13a1
1 of 15
No
No
Drer\atp13a2
1 of 15
No
No
Drer\atp13a3
1 of 15
No
No
Drer\si:dkey-28b4.8
1 of 15
No
No
Drer\si:dkey-211e20.10
1 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (17)
Cele\tat-2
11 of 15
Yes
Yes
Cele\tat-1
2 of 15
No
No
Cele\tat-3
2 of 15
No
No
Cele\tat-4
2 of 15
No
No
Cele\catp-1
1 of 15
No
No
Cele\catp-2
1 of 15
No
No
Cele\catp-3
1 of 15
No
No
Cele\catp-4
1 of 15
No
No
Cele\catp-5
1 of 15
No
No
Cele\catp-6
1 of 15
No
No
Cele\catp-8
1 of 15
No
No
Cele\mca-1
1 of 15
No
No
Cele\mca-2
1 of 15
No
No
Cele\pmr-1
1 of 15
No
No
Cele\sca-1
1 of 15
No
No
Cele\tat-5
1 of 15
No
No
Cele\tat-6
1 of 15
No
No
Arabidopsis thaliana (thale-cress) (12)
Atha\ACA.l
4 of 9
Yes
No
Atha\ALA3
4 of 9
Yes
No
Atha\AT1G17500
4 of 9
Yes
No
Atha\AT1G54280
4 of 9
Yes
No
Atha\AT1G68710
4 of 9
Yes
No
Atha\AT3G13900
4 of 9
Yes
No
Atha\AT3G25610
4 of 9
Yes
No
Atha\AT3G27870
4 of 9
Yes
No
Atha\AT1G26130
3 of 9
No
No
Atha\AT1G72700
3 of 9
No
No
Atha\ALA1
2 of 9
No
No
Atha\ALA2
1 of 9
No
No
Saccharomyces cerevisiae (Brewer's yeast) (13)
Scer\DNF1
4 of 15
Yes
No
Scer\DNF2
4 of 15
Yes
No
Scer\DNF3
2 of 15
No
No
Scer\DRS2
2 of 15
No
No
Scer\ENA1
1 of 15
No
No
Scer\ENA2
1 of 15
No
No
Scer\ENA5
1 of 15
No
No
Scer\PMA1
1 of 15
No
No
Scer\PMA2
1 of 15
No
No
Scer\PMC1
1 of 15
No
No
Scer\PMR1
1 of 15
No
No
Scer\SPF1
1 of 15
No
No
Scer\YPK9
1 of 15
No
No
Schizosaccharomyces pombe (Fission yeast) (3)
Spom\SPAC4F10.16c
2 of 12
Yes
No
Spom\SPAC24B11.12c
2 of 12
Yes
No
Spom\SPBC887.12
1 of 12
No
No
Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG091900G5 )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00008578
Drosophila simulans
Dsim\GD20604
Drosophila sechellia
Dsec\GM26043
Drosophila erecta
Dere\GG17161
Drosophila yakuba
Dyak\GE24551
Drosophila ananassae
Dana\GF17746
Drosophila pseudoobscura pseudoobscura
Dpse\GA13214
Drosophila persimilis
Dper\GL21577
Drosophila willistoni
Dwil\GK25424
Drosophila virilis
Dvir\GJ18766
Drosophila mojavensis
Dmoj\GI14418
Drosophila grimshawi
Dgri\GH24867
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091500CJ )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17020828
Glossina morsitans
Tsetse fly
Gmor\GMOY006051
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_14449
Mayetiola destructor
Hessian fly
Mdes\Mdes014057
Mayetiola destructor
Hessian fly
Mdes\Mdes010103
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL005495
Anopheles darlingi
American malaria mosquito
Adar\ADAC002815
Anopheles gambiae
Malaria mosquito
Agam\AGAP002644
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ008924
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W00A3 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA001552
Bombyx mori
Silkmoth
Bmor\BGIBMGA001553
Danaus plexippus
Monarch butterfly
Dple\DPOGS202529-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL007435
Apis florea
Little honeybee
Aflo\2935019652
Apis mellifera
Western honey bee
Amel\GB52189
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP22729
Bombus terrestris
Buff-tailed bumblebee
Bter\15214608
Linepithema humile
Argentine ant
Lhum\LH13744
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:001fde
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG006046
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_11616
Tribolium castaneum
Red flour beetle
Tcas\TC011007
Pediculus humanus
Human body louse
Phum\PHUM399950
Rhodnius prolixus
Kissing bug
Rpro\RPRC005592
Cimex lectularius
Bed bug
Clec\CLEC006501
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI088026
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_09024
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X011Y )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR012351
Ixodes scapularis
Black-legged tick
Isca\ISCW000685
Stegodyphus mimosarum
African social velvet spider
Smim\KFM74350.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM74360.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM74359.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur07g00420
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_317597
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0139 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Atp8a1
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Atp8b2
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Atp8a1_1
Ciona intestinalis
Vase tunicate
Cint\LOC100186827
Ciona intestinalis
Vase tunicate
Cint\LOC100185432
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000005896
Ciona intestinalis
Vase tunicate
Cint\LOC100179108
Gallus gallus
Domestic chicken
Ggal\LOC431656
Gallus gallus
Domestic chicken
Ggal\ATP8A2
Gallus gallus
Domestic chicken
Ggal\ATP8B3
Gallus gallus
Domestic chicken
Ggal\ATP8B1
Gallus gallus
Domestic chicken
Ggal\ATP10B
Gallus gallus
Domestic chicken
Ggal\ATP10A
Gallus gallus
Domestic chicken
Ggal\ATP8A1
Gallus gallus
Domestic chicken
Ggal\ATP8B2
Gallus gallus
Domestic chicken
Ggal\ATP10D
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (13)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
ATP8A
5 of 10
CG9981
5 of 10
CG4301
4 of 10
CG33298
4 of 10
CG31729
3 of 10
anne
1 of 10
Atpα
1 of 10
CG6230
1 of 10
CG30060
1 of 10
JYalpha
1 of 10
PMCA
1 of 10
SERCA
1 of 10
SPoCk
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 3 )
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    ATP8B2; ATPase phospholipid transporting 8B2
    12 of 15
    605867
        ATP8B4; ATPase phospholipid transporting 8B4 (putative)
        9 of 15
        609123
            ATP8B1; ATPase phospholipid transporting 8B1
            8 of 15
            602397
            ATP8B3; ATPase phospholipid transporting 8B3
            6 of 15
            605866
                ATP11A; ATPase phospholipid transporting 11A
                4 of 15
                605868
                    ATP11C; ATPase phospholipid transporting 11C
                    4 of 15
                    300516
                    ATP8A1; ATPase phospholipid transporting 8A1
                    3 of 15
                    609542
                        ATP8A2; ATPase phospholipid transporting 8A2
                        3 of 15
                        605870
                        ATP10B; ATPase phospholipid transporting 10B (putative)
                        3 of 15
                            ATP10D; ATPase phospholipid transporting 10D (putative)
                            3 of 15
                                ATP11B; ATPase phospholipid transporting 11B (putative)
                                3 of 15
                                605869
                                     
                                    Functional Complementation Data
                                    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
                                    Interactions
                                    Summary of Physical Interactions
                                    esyN Network Diagram
                                    Interactions Browser
                                    Summary of Genetic Interactions
                                    esyN Network Diagram
                                    esyN Network Key:
                                    Suppression
                                    Enhancement
                                    View in Interactions Browser
                                    Please look at the allele data for full details of the genetic interactions
                                    Starting gene(s)
                                    Interaction type
                                    Interacting gene(s)
                                    Reference
                                    ATP8B
                                    suppressible
                                    Or67d
                                    (Ha et al., 2014)
                                    Starting gene(s)
                                    Interaction type
                                    Interacting gene(s)
                                    Reference
                                    Or83c
                                    enhanceable
                                    ATP8B
                                    (Ha et al., 2014)
                                    External Data
                                    Linkouts
                                    DroID - A comprehensive database of gene and protein interactions.
                                    InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
                                    Pathways
                                    Signaling Pathways (FlyBase)
                                    Metabolic Pathways
                                    External Data
                                    Linkouts
                                    Genomic Location and Detailed Mapping Data
                                    Chromosome (arm)
                                    3R
                                    Recombination map

                                    3-51

                                    Cytogenetic map
                                    87A7-87A7
                                    Sequence location
                                    3R:12,068,375..12,090,612 [-]
                                    FlyBase Computed Cytological Location
                                    Cytogenetic map
                                    Evidence for location
                                    87A7-87A7
                                    Limits computationally determined from genome sequence between P{EP}Lk6EP886 and P{PZ}svp07842
                                    Experimentally Determined Cytological Location
                                    Cytogenetic map
                                    Notes
                                    References
                                    Experimentally Determined Recombination Data
                                    Location

                                    3-51

                                    (FlyBase, 2016)

                                    3-49.1

                                    (Comeron et al., 2012)
                                    Left of (cM)
                                    Right of (cM)
                                    Notes
                                    Stocks and Reagents
                                    Stocks (9)
                                    Genomic Clones (33)
                                    cDNA Clones (6)
                                     

                                    Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

                                    cDNA clones, fully sequenced
                                    BDGP DGC clones
                                      Other clones
                                      Drosophila Genomics Resource Center cDNA clones

                                      For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

                                      cDNA Clones, End Sequenced (ESTs)
                                      BDGP DGC clones
                                      Other clones
                                      RNAi and Array Information
                                      Linkouts
                                      DRSC - Results frm RNAi screens
                                      GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                                      Antibody Information
                                      Laboratory Generated Antibodies
                                       

                                      polyclonal

                                      (Ha et al., 2014, Liu et al., 2014)
                                      Commercially Available Antibodies
                                       
                                      Other Information
                                      Relationship to Other Genes
                                      Source for database identify of

                                      Source for identity of: ATP8B CG14741

                                      (Liu et al., 2014)
                                      Source for database merge of
                                      Additional comments
                                      Other Comments
                                      Origin and Etymology
                                      Discoverer
                                      Etymology

                                      Named 'ATP8B' after the human orthologs.

                                      (Liu et al., 2014)
                                      Identification
                                      External Crossreferences and Linkouts ( 54 )
                                      Sequence Crossreferences
                                      NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                                      GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                                      RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                                      UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
                                      Other crossreferences
                                      Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
                                      Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
                                      Flygut - An atlas of the Drosophila adult midgut
                                      GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                                      iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
                                      InterPro - A database of protein families, domains and functional sites
                                      KEGG Genes - Molecular building blocks of life in the genomic space.
                                      modMine - A data warehouse for the modENCODE project
                                      Linkouts
                                      DroID - A comprehensive database of gene and protein interactions.
                                      DRSC - Results frm RNAi screens
                                      FLIGHT - Cell culture data for RNAi and other high-throughput technologies
                                      FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                                      FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
                                      FlyMine - An integrated database for Drosophila genomics
                                      InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
                                      Synonyms and Secondary IDs (6)
                                      Datasets (0)
                                      Study focus (0)
                                      Experimental Role
                                      Project
                                      Project Type
                                      Title
                                      References (35)