FlyBase Gene Report: Dmel\ATP8B

General Information

Symbol

Dmel\ATP8B

Species

D. melanogaster

Name

ATPase 8B

Annotation Symbol

CG14741

Feature Type

protein_coding_gene

FlyBase ID

FBgn0037989

Gene Model Status

Current

Stock Availability

10 publicly available

Enzyme Name (EC)

P-type phospholipid transporter (7.6.2.1)

Gene Summary

ATPase 8B (ATP8B) encodes a phospholipid flippase involved in olfaction. [Date last reviewed: 2019-09-12] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Gene Group
Interactive Fly

Also Known As

dATP8B

Key Links

Genomic Location

Cytogenetic map

87A7-87A7

Sequence location

3R:12,068,375..12,090,612 [-]

Recombination map

3-51

RefSeq locus

NT_033777 REGION:12068375..12090612

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse GBrowse

Help me choose

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

GO Summary Ribbons

Gene Ontology (GO) Annotations (13 terms)

Molecular Function (4 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (4 terms)

CV Term

Evidence

References

enables ATP binding

inferred from electronic annotation with InterPro:IPR006539

(assigned by InterPro )

(FlyBase Curators et al., 2004-)

enables ATP hydrolysis activity

inferred from electronic annotation with InterPro:IPR001757

(assigned by InterPro )

(FlyBase Curators et al., 2004-)

enables ATPase-coupled intramembrane lipid transporter activity

inferred from sequence or structural similarity with SGD:S000000024

(Tanaka et al., 2011)

inferred from biological aspect of ancestor with PANTHER:PTN000642368

(assigned by GO_Central )

(Gaudet et al., 2011)

enables magnesium ion binding

inferred from electronic annotation with InterPro:IPR006539

(assigned by InterPro )

(FlyBase Curators et al., 2004-)

Biological Process (4 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

involved_in detection of chemical stimulus involved in sensory perception of smell

inferred from mutant phenotype

(Liu et al., 2014)

involved_in regulation of protein localization

inferred from mutant phenotype

(Ha et al., 2014)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

involved_in Golgi organization

inferred from biological aspect of ancestor with PANTHER:PTN001184364

(assigned by GO_Central )

(Gaudet et al., 2011)

involved_in phospholipid translocation

inferred from biological aspect of ancestor with PANTHER:PTN000642368

(assigned by GO_Central )

(Gaudet et al., 2011)

inferred from sequence or structural similarity with SGD:S000000024

(Tanaka et al., 2011)

Cellular Component (5 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

located_in cilium

inferred from direct assay

(Ha et al., 2014)

located_in sensory dendrite

inferred from direct assay

(Ha et al., 2014, Liu et al., 2014)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

located_in integral component of membrane

inferred from electronic annotation with InterPro:IPR001757, InterPro:IPR006539

(assigned by InterPro )

(FlyBase Curators et al., 2004-)

inferred from sequence model

(Tanaka et al., 2011)

is_active_in plasma membrane

inferred from biological aspect of ancestor with PANTHER:PTN000642368

(assigned by GO_Central )

(Gaudet et al., 2011)

is_active_in trans-Golgi network

inferred from biological aspect of ancestor with PANTHER:PTN001943259

(assigned by GO_Central )

(Gaudet et al., 2011)

Gene Group (FlyBase)

PHOSPHOLIPID TRANSPORTING ATPASES

Protein Family (UniProt)

Protein Signatures (InterPro)

Catalytic Activity (EC)

Experimental Evidence

Predictions / Assertions

ATP + H(2)O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2) (7.6.2.1)

Summaries

Gene Snapshot

ATPase 8B (ATP8B) encodes a phospholipid flippase involved in olfaction. [Date last reviewed: 2019-09-12]

Gene Group (FlyBase)

PHOSPHOLIPID TRANSPORTING ATPASES -: The phospholipid transporting type IV P-ATPases are flippases that translocate phospholipids against concentration gradient from one side of a membrane to the other. This lipid shuttling forms new membrane structures, in particular vesicles. (Adapted from PMID:18439418 and PMID:26240149).

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\ATP8B for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure New Section

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q9VGD4)

If you don't see the viewer to the right, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Comments on Gene Model

Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.49

Sequence Ontology: Class of Gene

nuclear_gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

ATP8B-RB

FBtr0300351

NM_169450

6697

1726

ATP8B-RC

FBtr0307015

NM_001260138

6500

1547

ATP8B-RD

FBtr0307016

NM_001260139

6007

1496

ATP8B-RF

FBtr0339643

NM_001300365

5810

1317

ATP8B-RG

FBtr0339644

NM_001300366

6245

1462

ATP8B-RH

FBtr0339645

NM_001260140

6458

1533

ATP8B-RI

FBtr0339646

NM_001300367

6203

1448

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank

ATP8B-PB

FBpp0289580

193.4

1726

7.67

NP_731669

AAF54749

ATP8B-PC

FBpp0297858

173.3

1547

7.41

NP_001247067

AFH06385

ATP8B-PD

FBpp0297859

168.2

1496

6.62

NP_001247068

AFH06386

ATP8B-PF

FBpp0308705

148.2

1317

6.38

NP_001287294

AHN57293

ATP8B-PG

FBpp0308706

163.5

1462

6.88

NP_001287295

AHN57294

ATP8B-PH

FBpp0308707

171.7

1533

7.41

NP_001247069

AFH06387

ATP8B-PI

FBpp0308708

161.9

1448

6.88

NP_001287296

AHN57295

Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\ATP8B using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Linkouts

Expression Data

Expression Summary Ribbons

Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.

For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.

Transcript Expression

microinjection

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage -- adult stage

(Ha et al., 2014)

adult stage

antenna

Comment: transcripts lacking variable exon enriched in antenna

(Ha et al., 2014)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

immunolocalization

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

basiconic sensillum of antennal segment 3

(Liu et al., 2014)

trichoid sensillum of antennal segment 3

(Liu et al., 2014)

adult olfactory receptor neuron | subset

• dendrite

(Liu et al., 2014)

adult olfactory receptor neuron Or67d

(Ha et al., 2014)

adult olfactory receptor neuron

Comment: expressed in all Orco-expressing olfactory neurons

(Ha et al., 2014)

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

Additional Descriptive Data

ATP8B-protein is expressed in the outer dendrites of Orco-expressing adult olfactory receptor neurons. These labeled dendrites are located in the shafts of both basiconic and trichoid sensilla.

(Liu et al., 2014)

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in cilium

inferred from direct assay

(Ha et al., 2014)

located_in sensory dendrite

inferred from direct assay

(Ha et al., 2014, Liu et al., 2014)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\ATP8B in GBrowse 2

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\ATP8B

View exonic expression by tissue for Dmel\ATP8B

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

41469/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0037989

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0037989

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0037989

Flygut - An atlas of the Drosophila adult midgut

FBgn0037989

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 11 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 8 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of ATP8B

Transgenic constructs containing regulatory region of ATP8B

Aberrations (Deficiencies and Duplications) ( 3 )

Inferred from experimentation ( 3 )

Gene disrupted in

Df(3R)Exel6162

(Ryder, 2004.4.26)

Df(3R)Exel7312

(Liu et al., 2014, Ryder, 2004.4.26)

Df(3R)Exel8155

(Liu et al., 2014, Ryder, 2004.4.26)

Gene partially disrupted in

Df(3R)Exel7312

(Liu et al., 2014)

Inferred from location ( 0 )

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

viable

Sterility

Allele

fertile

ATP8B^f05203

Other Phenotypes

Allele

abnormal neurophysiology

abnormal neurophysiology, with ATP8B^E351Q.UAS, Scer\GAL4^Or67d-GAL4-2

ATP8B^f05203

abnormal neurophysiology, with ATP8B^f05203, Scer\GAL4^Or67d-GAL4-2

ATP8B^E351Q.UAS

abnormal neurophysiology (with ATP8B^f05203)

ATP8B^ll2

abnormal neurophysiology (with ATP8B^ll2)

ATP8B^f05203

abnormal neurophysiology (with Df(3R)Exel7312)

ATP8B^ll2

abnormal neurophysiology (with Df(3R)Exel8155)

ATP8B^ll2

abnormal smell perception

abnormal smell perception (with ATP8B^f05203)

ATP8B^ll2

abnormal smell perception (with ATP8B^ll2)

ATP8B^f05203

abnormal smell perception (with Df(3R)Exel7312)

ATP8B^ll2

abnormal smell perception (with Df(3R)Exel8155)

ATP8B^ll2

short lived

ATP8B^f05203

Phenotype manifest in

Allele

adult antennal olfactory receptor neuron

ATP8B^f05203

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v8.0)

Homo sapiens (Human) (34)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Hsap\ATP8B2

12 of 15

Yes

Hsap\ATP8B4

9 of 15

Yes

Hsap\ATP8B1

8 of 15

Yes

Hsap\ATP8B3

6 of 15

Yes

4 of 15

4 of 15

3 of 15

3 of 15

3 of 15

3 of 15

3 of 15

2 of 15

2 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Model Organism Orthologs (via DIOPT v8.0)

Mus musculus (laboratory mouse) (35)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Mmus\Atp8b2

11 of 15

Yes

Mmus\Atp8b4

9 of 15

Yes

Mmus\Atp8b5

9 of 15

Yes

Mmus\Atp8b1

8 of 15

Yes

Mmus\Atp8b3

6 of 15

Yes

4 of 15

4 of 15

3 of 15

3 of 15

3 of 15

3 of 15

2 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Rattus norvegicus (Norway rat) (30)

Rnor\Atp8b2

9 of 13

Yes

Rnor\Atp8b1

8 of 13

Yes

Rnor\Atp8b3

6 of 13

Yes

4 of 13

4 of 13

3 of 13

3 of 13

Yes

Rnor\Atp10b

3 of 13

Rnor\Atp10d

3 of 13

Rnor\Atp8b4

2 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Xenopus tropicalis (Western clawed frog) (31)

Xtro\atp8b1

8 of 12

Yes

Xtro\LOC100490503

6 of 12

Yes

Xtro\atp8b3

5 of 12

Yes

Xtro\atp8b4

5 of 12

Yes

3 of 12

3 of 12

3 of 12

2 of 12

2 of 12

2 of 12

2 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Yes

Danio rerio (Zebrafish) (39)

Drer\atp8b1

8 of 15

Yes

Drer\atp8b4

7 of 15

Yes

Drer\atp8b5b

7 of 15

Yes

Drer\atp8b3

6 of 15

Yes

Drer\atp8b5a

6 of 15

Yes

4 of 15

4 of 15

3 of 15

3 of 15

3 of 15

Yes

Drer\atp10b

3 of 15

Drer\atp10d

3 of 15

Drer\atp9a

2 of 15

Yes

2 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Drer\si:dkey-211e20.10

1 of 15

Caenorhabditis elegans (Nematode, roundworm) (17)

Cele\tat-2

11 of 15

Yes

2 of 15

2 of 15

2 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Arabidopsis thaliana (thale-cress) (12)

Atha\ACA.l

4 of 9

Yes

Atha\ALA3

4 of 9

Yes

Atha\AT1G17500

4 of 9

Yes

Atha\AT1G54280

4 of 9

Yes

Atha\AT1G68710

4 of 9

Yes

Atha\AT3G13900

4 of 9

Yes

Atha\AT3G25610

4 of 9

Yes

Atha\AT3G27870

4 of 9

Yes

3 of 9

3 of 9

2 of 9

1 of 9

Saccharomyces cerevisiae (Brewer's yeast) (13)

Scer\DNF1

4 of 15

Yes

Scer\DNF2

4 of 15

Yes

2 of 15

2 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Schizosaccharomyces pombe (Fission yeast) (3)

Spom\SPAC4F10.16c

2 of 12

Yes

Spom\SPAC24B11.12c

2 of 12

Yes

Spom\SPBC887.12

1 of 12

Other Organism Orthologs (via OrthoDB)

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v8.0)

Drosophila melanogaster (Fruit fly) (13)

Gene Symbol

Score

Source

Alignment

5 of 10

5 of 10

4 of 10

4 of 10

3 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Model Summary Ribbon

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 3 )

Human Ortholog

Disease

Evidence

References

ATP8B1; ATPase phospholipid transporting 8B1

model of progressive familial intrahepatic cholestasis 1

IEA

(FlyBase, 2019-)

model of benign recurrent intrahepatic cholestasis 1

IEA

(FlyBase, 2019-)

model of intrahepatic cholestasis of pregnancy 1

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

ATP8B2; ATPase phospholipid transporting 8B2

12 of 15

605867

ATP8B4; ATPase phospholipid transporting 8B4 (putative)

9 of 15

609123

ATP8B1; ATPase phospholipid transporting 8B1

8 of 15

602397

ATP8B3; ATPase phospholipid transporting 8B3

6 of 15

605866

ATP11A; ATPase phospholipid transporting 11A

4 of 15

605868

ATP11C; ATPase phospholipid transporting 11C

4 of 15

300516

HEMOLYTIC ANEMIA, CONGENITAL, X-LINKED

X-linked congenital hemolytic anemia

ATP8A1; ATPase phospholipid transporting 8A1

3 of 15

609542

ATP8A2; ATPase phospholipid transporting 8A2

3 of 15

605870

CEREBELLAR ATAXIA, MENTAL RETARDATION, AND DYSEQUILIBRIUM SYNDROME 4; CAMRQ4

cerebellar ataxia, mental retardation and dysequlibrium syndrome

ATP10B; ATPase phospholipid transporting 10B (putative)

3 of 15

ATP10D; ATPase phospholipid transporting 10D (putative)

3 of 15

ATP11B; ATPase phospholipid transporting 11B (putative)

3 of 15

605869

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Interactions Browser

Summary of Genetic Interactions

esyN Network Diagram

esyN Network Key:

Suppression

Enhancement

View in Interactions Browser

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

ATP8B

suppressible

Or67d

(Ha et al., 2014)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Or83c

enhanceable

ATP8B

(Ha et al., 2014)

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0037989

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0037989

External Data

Linkouts

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

3-51

Cytogenetic map

87A7-87A7

Sequence location

3R:12,068,375..12,090,612 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

87A7-87A7

Limits computationally determined from genome sequence between P{EP}Lk6^EP886 and P{PZ}svp⁰⁷⁸⁴²

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

3-51

(FlyBase, 2016)

3-49.1

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (10)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

18847

w¹¹¹⁸; PBac{WH}ATP8B^f05203

63037

y¹ v¹; P{TRiP.HMS05311}attP40

63302

w¹¹¹⁸; PBac{IT.GAL4}ATP8B^0415-G4

35963

y¹ w^*; Mi{MIC}ATP8B^MI02110

38110

y¹ w^*; Mi{MIC}ATP8B^MI02325

43090

y¹ w^*; Mi{MIC}ATP8B^MI06979

91431

y¹ w^*; TI{CRIMIC.TG4.0}ATP8B^{CR01903-TG4.0}

VDRC

v330195

P{VSH330195}attP40

v102648

P{KK103739}VIE-260B

v342463

P{hsFLP}1, y¹ w¹¹¹⁸; P{HD_CFD01558}attP40/CyO-GFP

Genomic Clones (33)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (6)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

IP14033

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0037989

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

GM23677

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0037989

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

41469

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Ha et al., 2014, Liu et al., 2014)

Commercially Available Antibodies

Other Information

Relationship to Other Genes

Source for database identify of

Source for identity of: ATP8B CG14741

(Liu et al., 2014)

Source for database merge of

Additional comments

Other Comments

Origin and Etymology

Discoverer

Etymology

Named 'ATP8B' after the human orthologs.

(Liu et al., 2014)

Identification

External Crossreferences and Linkouts ( 60 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

41469

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q9VGD4

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q9VGD4

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0037989

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

41469/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0037989

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0037989

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0037989

Flygut - An atlas of the Drosophila adult midgut

FBgn0037989

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0037989

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

41469

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC011007

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

Dmel_CG14741

MARRVEL_MODEL - MARRVEL (model organism gene)

41469

modMine - A data warehouse for the modENCODE project

FBgn0037989

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0037989

DRSC - Results frm RNAi screens

FBgn0037989

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0037989

FlyMine - An integrated database for Drosophila genomics

FBgn0037989

Synonyms and Secondary IDs (6)

Reported As

Symbol Synonym

ATP8B

(Hurbain et al., 2022, Cattenoz et al., 2021, McLaughlin et al., 2021, Shiomi et al., 2021, Schmidt and Benton, 2020, Gene Disruption Project members, 2018-, Clandinin and Owens, 2016-)

CG14741

(Meadows, 2017.1.11, Danilov et al., 2015, Ha et al., 2014, Liu et al., 2014, Ida et al., 2013, Kwon et al., 2013, Ma et al., 2012, Anholt and Williams, 2010, Keleman et al., 2009.8.5, Perkins et al., 2009)

DmCG14741

(Tanaka et al., 2011)

atp8b

(Zhou et al., 2015)

dATP8B

(Ha et al., 2014, Liu et al., 2014)

Name Synonyms

ATPase 8B

Secondary FlyBase IDs

Datasets (8)

Study focus (0)

Experimental Role