FlyBase Gene Report: Dmel\dpr15

DEFECTIVE PROBOSCIS EXTENSION RESPONSE -: Defective proboscis extension response (Dpr) cell surface proteins are members of the immunoglobulin superfamily. They form a complex interaction network with Dpr-interacting proteins (DIPs), acting as neuronal surface labels in the specificity of synaptic connections between neurons and target cells. (Adapted from FBrf0230454 and FBrf0149073).

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the GBrowse view of Dmel\dpr15 or the JBrowse view of Dmel\dpr15 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Comments on Gene Model

Annotated transcripts do not represent all supported alternative splices within 5' UTR.

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.49

Sequence Ontology: Class of Gene

nuclear_gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

dpr15-RA

FBtr0082549

NM_169453

3490

662

dpr15-RB

FBtr0339647

NM_001300370

3474

662

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank

dpr15-PA

FBpp0082022

70.2

662

9.13

NP_731672

AAF54753

dpr15-PB

FBpp0308709

70.2

662

9.13

NP_001287299

AHN57298

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

662 aa isoforms: dpr15-PA, dpr15-PB

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\dpr15 using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

dpr15_1

Linkouts

Gene Ontology (3 terms)

Molecular Function (0 terms)

There is no information supporting a Molecular Function term for this gene. (Based on a review of available data on: 2013-02-08 )

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (0 terms)

Biological Process (2 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

synapse organization

inferred from expression pattern

(Carrillo et al., 2015)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

sensory perception of chemical stimulus

inferred from sequence or structural similarity with FLYBASE:dpr1; FB:FBgn0040726

(Nakamura et al., 2002)

synapse organization

inferred from biological aspect of ancestor with PANTHER:PTN000589413

(assigned by GO_Central )

(Gaudet et al., 2011)

Cellular Component (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

neuron projection membrane

inferred from biological aspect of ancestor with PANTHER:PTN000589413

(assigned by GO_Central )

(Gaudet et al., 2011)

Expression Data

Expression Summary Ribbons

Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.

For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.

Transcript Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\dpr15 in GBrowse 2

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\dpr15

View exonic expression by tissue for Dmel\dpr15

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0037993

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

FBgn0037993

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

CG10095-RA

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG10095

Flygut - An atlas of the Drosophila adult midgut

FBgn0037993

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, and Transgenic Constructs

Classical and Insertion Alleles ( 4 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 2 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of dpr15

Transgenic constructs containing regulatory region of dpr15

Deletions and Duplications ( 2 )

Disrupted in

Df(3R)Exel6162

(Ryder, 2004.4.26)

Df(3R)Exel7313

(Ryder, 2004.4.26)

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

partially lethal - majority die, with Scer\GAL4^pnr-MD237

dpr15^GD16391

partially lethal - majority die | adult stage, with Scer\GAL4^pnr-MD237

dpr15^GD14615

viable

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

viable, with Scer\GAL4^Mef2.PR

Other Phenotypes

Allele

body color defective, with Scer\GAL4^pnr-MD237

dpr15^GD16391

flightless, with Scer\GAL4^Mef2.PR

dpr15^GD16391

pain response defective | adult stage, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

dpr15^GD14615

some die during pupal stage, with Scer\GAL4^pnr-MD237

dpr15^GD16391

visible, with Scer\GAL4^pnr-MD237

Phenotype manifest in

Allele

mesothoracic tergum, with Scer\GAL4^pnr-MD237

dpr15^GD16391

myofibril, with Scer\GAL4^Mef2.PR

dpr15^GD16391

sarcomere, with Scer\GAL4^Mef2.PR

dpr15^GD16391

trichogen cell, with Scer\GAL4^pnr-MD237

dpr15^GD14615

Z disc, with Scer\GAL4^Mef2.PR

dpr15^GD16391

Orthologs

Downloads

Download All DIOPT Orthologs

Download All OrthoDB Orthologs

Human Orthologs (via DIOPT v7.1)

Homo sapiens (Human) (13)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Hsap\CADM1

1 of 15

Yes

Hsap\CADM2

1 of 15

Yes

Hsap\CADM3

1 of 15

Yes

Hsap\CADM4

1 of 15

Yes

Hsap\IGSF9B

1 of 15

Yes

Hsap\KIRREL1

1 of 15

Yes

Hsap\KIRREL2

1 of 15

Yes

Hsap\KIRREL3

1 of 15

Yes

Hsap\LRIT1

1 of 15

Yes

Hsap\LRIT3

1 of 15

Yes

Hsap\PAPLN

1 of 15

Yes

Hsap\SDK1

1 of 15

Yes

Hsap\USH2A

1 of 15

Yes

Model Organism Orthologs (via DIOPT v7.1)

Mus musculus (laboratory mouse) (13)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Mmus\Cadm1

1 of 15

Yes

Mmus\Cadm2

1 of 15

Yes

Mmus\Cadm3

1 of 15

Yes

Mmus\Cadm4

1 of 15

Yes

Mmus\Igsf9b

1 of 15

Yes

Mmus\Kirrel2

1 of 15

Yes

Mmus\Kirrel3

1 of 15

Yes

Mmus\Kirrel

1 of 15

Yes

Mmus\Lrit1

1 of 15

Yes

Mmus\Lrit3

1 of 15

Yes

Mmus\Papln

1 of 15

Yes

Mmus\Ptprq

1 of 15

Yes

Mmus\Sdk1

1 of 15

Yes

Rattus norvegicus (Norway rat) (12)

Rnor\Cadm1

1 of 13

Yes

Rnor\Cadm2

1 of 13

Yes

Rnor\Cadm3

1 of 13

Yes

Rnor\Cadm4

1 of 13

Yes

Rnor\Hmcn1

1 of 13

Yes

Rnor\Igsf9b

1 of 13

Yes

Rnor\Kirrel1

1 of 13

Yes

Rnor\Kirrel2

1 of 13

Yes

Rnor\Kirrel3

1 of 13

Yes

Rnor\Lrit1

1 of 13

Yes

Rnor\Obscn

1 of 13

Yes

Rnor\Opcml

1 of 13

Yes

Xenopus tropicalis (Western clawed frog) (4)

Xtro\igsf9b

1 of 12

Yes

Xtro\kirrel2

1 of 12

Yes

Xtro\lrit3

1 of 12

Yes

Xtro\papln

1 of 12

Yes

Danio rerio (Zebrafish) (22)

Drer\dscama

1 of 15

Yes

Drer\dscamb

1 of 15

Yes

Drer\igsf9a

1 of 15

Yes

Drer\igsf9bb

1 of 15

Yes

Drer\itgb4

1 of 15

Yes

Drer\kirrel1a

1 of 15

Yes

Drer\kirrel1b

1 of 15

Yes

Drer\kirrel3a

1 of 15

Yes

Drer\kirrel3b

1 of 15

Yes

Drer\kirrel3l

1 of 15

Yes

Drer\LOC101885725

1 of 15

Yes

Drer\lrit1a

1 of 15

Yes

Drer\lrit1b

1 of 15

Yes

Drer\lrit3a

1 of 15

Yes

Drer\lrit3b

1 of 15

Yes

Drer\ncam1b

1 of 15

Yes

Drer\paplna

1 of 15

Yes

Drer\sdk1a

1 of 15

Yes

Drer\sdk1b

1 of 15

Yes

Drer\si:ch211-163c2.2

1 of 15

Yes

Drer\si:ch1073-459j12.1

1 of 15

Yes

Drer\ush2a

1 of 15

Yes

Caenorhabditis elegans (Nematode, roundworm) (4)

Cele\zig-8

2 of 15

Yes

Cele\C53A5.13

1 of 15

Yes

Cele\rig-3

1 of 15

Yes

Cele\zig-10

1 of 15

Yes

Arabidopsis thaliana (thale-cress) (0)

No records found.

Saccharomyces cerevisiae (Brewer's yeast) (0)

No records found.

Schizosaccharomyces pombe (Fission yeast) (0)

No records found.

Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG09190BPB )

Organism

Common Name

Gene

AAA Syntenic Ortholog

Multiple Dmel Genes in this Orthologous Group

Drosophila melanogaster

fruit fly

Dmel\dpr15

Drosophila suzukii

Spotted wing Drosophila

Dsuz\DS10_00008574

Drosophila suzukii

Spotted wing Drosophila

Drosophila simulans

Drosophila sechellia

Drosophila erecta

Drosophila yakuba

Drosophila ananassae

Drosophila pseudoobscura pseudoobscura

Dpse\GA10069

Drosophila persimilis

Dper\GL21574

Drosophila willistoni

Dwil\GK11567

Drosophila virilis

Dvir\GJ10069

Drosophila mojavensis

Dmoj\GI22469

Drosophila grimshawi

Dgri\GH15510

Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG09150306 )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Musca domestica

House fly

Mdoa\17021958

Lucilia cuprina

Australian sheep blowfly

Lcup\FF38_08506

Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W0PR4 )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Bombyx mori

Silkmoth

Bmor\BGIBMGA012382

Bombyx mori

Silkmoth

Bmor\BGIBMGA003965

Bombyx mori

Silkmoth

Bmor\BGIBMGA007216

Bombyx mori

Silkmoth

Bmor\BGIBMGA013888

Bombyx mori

Silkmoth

Bmor\BGIBMGA010535

Bombyx mori

Silkmoth

Bmor\BGIBMGA000193

Bombyx mori

Silkmoth

Bmor\BGIBMGA014206

Bombyx mori

Silkmoth

Bmor\BGIBMGA001545

Bombyx mori

Silkmoth

Bmor\BGIBMGA001286

Bombyx mori

Silkmoth

Bmor\BGIBMGA013755

Danaus plexippus

Monarch butterfly

Dple\DPOGS208163-PA

Danaus plexippus

Monarch butterfly

Dple\DPOGS205598-PA

Danaus plexippus

Monarch butterfly

Dple\DPOGS203110-PA

Danaus plexippus

Monarch butterfly

Dple\DPOGS209896-PA

Danaus plexippus

Monarch butterfly

Dple\DPOGS206247-PA

Danaus plexippus

Monarch butterfly

Dple\DPOGS211358-PA

Danaus plexippus

Monarch butterfly

Dple\DPOGS209302-PA

Danaus plexippus

Monarch butterfly

Dple\DPOGS206250-PA

Danaus plexippus

Monarch butterfly

Dple\DPOGS214345-PA

Danaus plexippus

Monarch butterfly

Dple\DPOGS202517-PA

Danaus plexippus

Monarch butterfly

Dple\DPOGS206579-PA

Danaus plexippus

Monarch butterfly

Dple\DPOGS215421-PA

Danaus plexippus

Monarch butterfly

Dple\DPOGS210612-PA

Danaus plexippus

Monarch butterfly

Dple\DPOGS202050-PA

Heliconius melpomene

Postman butterfly

Hmel\HMEL017455

Heliconius melpomene

Postman butterfly

Hmel\HMEL005895

Heliconius melpomene

Postman butterfly

Hmel\HMEL004236

Heliconius melpomene

Postman butterfly

Hmel\HMEL015385

Heliconius melpomene

Postman butterfly

Hmel\HMEL011101

Heliconius melpomene

Postman butterfly

Hmel\HMEL003046

Heliconius melpomene

Postman butterfly

Hmel\HMEL018058

Heliconius melpomene

Postman butterfly

Hmel\HMEL005985

Heliconius melpomene

Postman butterfly

Hmel\HMEL004804

Heliconius melpomene

Postman butterfly

Hmel\HMEL017922

Heliconius melpomene

Postman butterfly

Hmel\HMEL013417

Heliconius melpomene

Postman butterfly

Hmel\HMEL015365

Apis florea

Little honeybee

Aflo\2417180518

Apis florea

Little honeybee

Aflo\3131127988

Apis florea

Little honeybee

Aflo\4250949204

Apis florea

Little honeybee

Aflo\3079719972

Apis florea

Little honeybee

Aflo\2702348164

Apis florea

Little honeybee

Aflo\2396217188

Apis florea

Little honeybee

Aflo\2163659954

Apis florea

Little honeybee

Aflo\3438323492

Apis florea

Little honeybee

Aflo\2459072772

Apis florea

Little honeybee

Aflo\4806685908

Apis florea

Little honeybee

Aflo\2147492609

Apis florea

Little honeybee

Aflo\4084224804

Apis florea

Little honeybee

Aflo\2359502756

Apis florea

Little honeybee

Aflo\2147489233

Apis florea

Little honeybee

Aflo\2147491617

Apis mellifera

Western honey bee

Amel\GB47707

Apis mellifera

Western honey bee

Amel\GB53574

Apis mellifera

Western honey bee

Amel\GB51181

Apis mellifera

Western honey bee

Amel\GB40061

Apis mellifera

Western honey bee

Amel\GB41414

Apis mellifera

Western honey bee

Amel\GB54299

Apis mellifera

Western honey bee

Amel\GB51183

Apis mellifera

Western honey bee

Amel\GB44739

Apis mellifera

Western honey bee

Amel\GB42260

Apis mellifera

Western honey bee

Amel\GB53294

Apis mellifera

Western honey bee

Amel\GB55000

Apis mellifera

Western honey bee

Amel\GB42584

Apis mellifera

Western honey bee

Amel\LOC724734

Apis mellifera

Western honey bee

Amel\GB40069

Apis mellifera

Western honey bee

Amel\GB42576

Bombus impatiens

Common eastern bumble bee

Bimp\BIMP21795

Bombus impatiens

Common eastern bumble bee

Bimp\BIMP22921

Bombus impatiens

Common eastern bumble bee

Bimp\BIMP15340

Bombus impatiens

Common eastern bumble bee

Bimp\BIMP22624

Bombus impatiens

Common eastern bumble bee

Bimp\BIMP17123

Bombus impatiens

Common eastern bumble bee

Bimp\BIMP21544

Bombus impatiens

Common eastern bumble bee

Bimp\BIMP15404

Bombus impatiens

Common eastern bumble bee

Bimp\BIMP17530

Bombus impatiens

Common eastern bumble bee

Bimp\BIMP15359

Bombus impatiens

Common eastern bumble bee

Bimp\BIMP20882

Bombus impatiens

Common eastern bumble bee

Bimp\BIMP12821

Bombus impatiens

Common eastern bumble bee

Bimp\BIMP14517

Bombus impatiens

Common eastern bumble bee

Bimp\BIMP20466

Bombus impatiens

Common eastern bumble bee

Bimp\BIMP21537

Bombus impatiens

Common eastern bumble bee

Bimp\BIMP23709

Bombus terrestris

Buff-tailed bumblebee

Bter\15211856

Bombus terrestris

Buff-tailed bumblebee

Bter\15205136

Bombus terrestris

Buff-tailed bumblebee

Bter\15205403

Bombus terrestris

Buff-tailed bumblebee

Bter\15203435

Bombus terrestris

Buff-tailed bumblebee

Bter\15206820

Bombus terrestris

Buff-tailed bumblebee

Bter\15206745

Bombus terrestris

Buff-tailed bumblebee

Bter\15206693

Bombus terrestris

Buff-tailed bumblebee

Bter\15208510

Bombus terrestris

Buff-tailed bumblebee

Bter\15214139

Bombus terrestris

Buff-tailed bumblebee

Bter\15208036

Bombus terrestris

Buff-tailed bumblebee

Bter\15205025

Bombus terrestris

Buff-tailed bumblebee

Bter\15211859

Bombus terrestris

Buff-tailed bumblebee

Bter\15207219

Bombus terrestris

Buff-tailed bumblebee

Bter\15206846

Linepithema humile

Argentine ant

Lhum\LH20666

Linepithema humile

Argentine ant

Lhum\LH24144

Linepithema humile

Argentine ant

Lhum\LH15450

Linepithema humile

Argentine ant

Lhum\LH21711

Linepithema humile

Argentine ant

Lhum\LH11455

Linepithema humile

Argentine ant

Lhum\LH15813

Linepithema humile

Argentine ant

Lhum\LH24235

Linepithema humile

Argentine ant

Lhum\LH13914

Linepithema humile

Argentine ant

Lhum\LH13903

Linepithema humile

Argentine ant

Lhum\LH17266

Linepithema humile

Argentine ant

Lhum\LH11448

Linepithema humile

Argentine ant

Lhum\LH19816

Megachile rotundata

Alfalfa leafcutting bee

Mrot\MROTU:0017e5

Megachile rotundata

Alfalfa leafcutting bee

Mrot\MROTU:0015e4

Megachile rotundata

Alfalfa leafcutting bee

Mrot\MROTU:000c21

Megachile rotundata

Alfalfa leafcutting bee

Mrot\MROTU:000441

Megachile rotundata

Alfalfa leafcutting bee

Mrot\MROTU:002375

Megachile rotundata

Alfalfa leafcutting bee

Mrot\MROTU:001379

Megachile rotundata

Alfalfa leafcutting bee

Mrot\MROTU:000cea

Megachile rotundata

Alfalfa leafcutting bee

Mrot\MROTU:001a70

Megachile rotundata

Alfalfa leafcutting bee

Mrot\MROTU:0017da

Megachile rotundata

Alfalfa leafcutting bee

Mrot\MROTU:002e27

Megachile rotundata

Alfalfa leafcutting bee

Mrot\MROTU:000451

Megachile rotundata

Alfalfa leafcutting bee

Mrot\MROTU:000450

Megachile rotundata

Alfalfa leafcutting bee

Mrot\MROTU:001328

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG014312

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG026492

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG008252

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG016852

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG012731

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG008188

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG031947

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG014303

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG010416

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG012803

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG009357

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG026490

Dendroctonus ponderosae

Mountain pine beetle

Dpod\YQE_00197

Dendroctonus ponderosae

Mountain pine beetle

Dpod\YQE_08735

Dendroctonus ponderosae

Mountain pine beetle

Dpod\YQE_10981

Dendroctonus ponderosae

Mountain pine beetle

Dpod\YQE_09070

Dendroctonus ponderosae

Mountain pine beetle

Dpod\YQE_11783

Dendroctonus ponderosae

Mountain pine beetle

Dpod\YQE_02239

Dendroctonus ponderosae

Mountain pine beetle

Dpod\YQE_11782

Dendroctonus ponderosae

Mountain pine beetle

Dpod\YQE_08745

Dendroctonus ponderosae

Mountain pine beetle

Dpod\YQE_03172

Dendroctonus ponderosae

Mountain pine beetle

Dpod\YQE_05970

Dendroctonus ponderosae

Mountain pine beetle

Dpod\YQE_11781

Dendroctonus ponderosae

Mountain pine beetle

Dpod\YQE_10980

Dendroctonus ponderosae

Mountain pine beetle

Dpod\YQE_08740

Dendroctonus ponderosae

Mountain pine beetle

Dpod\YQE_09092

Dendroctonus ponderosae

Mountain pine beetle

Dpod\YQE_02236

Dendroctonus ponderosae

Mountain pine beetle

Dpod\YQE_05826

Tribolium castaneum

Red flour beetle

Tcas\TC014172

Tribolium castaneum

Red flour beetle

Tcas\TC032133

Tribolium castaneum

Red flour beetle

Tcas\TC010127

Tribolium castaneum

Red flour beetle

Tcas\TC013655

Tribolium castaneum

Red flour beetle

Tcas\TC010603

Tribolium castaneum

Red flour beetle

Tcas\TC033556

Tribolium castaneum

Red flour beetle

Tcas\TC008933

Tribolium castaneum

Red flour beetle

Tcas\TC009101

Tribolium castaneum

Red flour beetle

Tcas\TC004621

Tribolium castaneum

Red flour beetle

Tcas\TC033698

Tribolium castaneum

Red flour beetle

Tcas\TC010130

Tribolium castaneum

Red flour beetle

Tcas\TC034457

Tribolium castaneum

Red flour beetle

Tcas\TC030995

Pediculus humanus

Human body louse

Phum\PHUM383040

Pediculus humanus

Human body louse

Phum\PHUM065930

Pediculus humanus

Human body louse

Phum\PHUM595090

Pediculus humanus

Human body louse

Phum\PHUM413630

Pediculus humanus

Human body louse

Phum\PHUM371260

Pediculus humanus

Human body louse

Phum\PHUM307810

Pediculus humanus

Human body louse

Phum\PHUM382820

Pediculus humanus

Human body louse

Phum\PHUM048790

Pediculus humanus

Human body louse

Phum\PHUM417160

Pediculus humanus

Human body louse

Phum\PHUM383760

Pediculus humanus

Human body louse

Phum\PHUM170650

Pediculus humanus

Human body louse

Phum\PHUM121360

Pediculus humanus

Human body louse

Phum\PHUM385160

Pediculus humanus

Human body louse

Phum\PHUM046150

Rhodnius prolixus

Kissing bug

Rpro\RPRC003049

Rhodnius prolixus

Kissing bug

Rpro\RPRC003034

Rhodnius prolixus

Kissing bug

Rpro\RPRC011156

Rhodnius prolixus

Kissing bug

Rpro\RPRC001258

Rhodnius prolixus

Kissing bug

Rpro\RPRC007179

Rhodnius prolixus

Kissing bug

Rpro\RPRC001654

Rhodnius prolixus

Kissing bug

Rpro\RPRC002071

Rhodnius prolixus

Kissing bug

Rpro\RPRC002652

Rhodnius prolixus

Kissing bug

Rpro\RPRC005435

Cimex lectularius

Bed bug

Clec\CLEC000635

Cimex lectularius

Bed bug

Clec\CLEC008185

Cimex lectularius

Bed bug

Clec\CLEC012784

Cimex lectularius

Bed bug

Clec\CLEC013183

Cimex lectularius

Bed bug

Clec\CLEC008244

Cimex lectularius

Bed bug

Clec\CLEC002918

Cimex lectularius

Bed bug

Clec\CLEC000637

Cimex lectularius

Bed bug

Clec\CLEC007277

Cimex lectularius

Bed bug

Clec\CLEC006324

Cimex lectularius

Bed bug

Clec\CLEC012689

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI37669

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI001500

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI005117

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI085714

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI000744

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI007143

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI006858

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI000101

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI005884

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI003058

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI064251

Zootermopsis nevadensis

Nevada dampwood termite

Znev\Znev_18076

Zootermopsis nevadensis

Nevada dampwood termite

Znev\Znev_09296

Zootermopsis nevadensis

Nevada dampwood termite

Znev\Znev_17958

Zootermopsis nevadensis

Nevada dampwood termite

Znev\Znev_17530

Zootermopsis nevadensis

Nevada dampwood termite

Znev\Znev_00600

Zootermopsis nevadensis

Nevada dampwood termite

Znev\Znev_15530

Zootermopsis nevadensis

Nevada dampwood termite

Znev\Znev_17473

Zootermopsis nevadensis

Nevada dampwood termite

Znev\Znev_01763

Zootermopsis nevadensis

Nevada dampwood termite

Znev\Znev_18036

Zootermopsis nevadensis

Nevada dampwood termite

Znev\Znev_18613

Zootermopsis nevadensis

Nevada dampwood termite

Znev\Znev_18483

Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X0FMW )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strigamia maritima

European centipede

Smar\SMAR009512

Strigamia maritima

European centipede

Smar\SMAR014426

Strigamia maritima

European centipede

Smar\SMAR012075

Strigamia maritima

European centipede

Smar\SMAR012076

Strigamia maritima

European centipede

Smar\SMAR005541

Strigamia maritima

European centipede

Smar\SMAR014109

Strigamia maritima

European centipede

Smar\SMAR013494

Ixodes scapularis

Black-legged tick

Isca\ISCW023418

Ixodes scapularis

Black-legged tick

Isca\ISCW021113

Ixodes scapularis

Black-legged tick

Isca\ISCW012168

Ixodes scapularis

Black-legged tick

Isca\ISCW014701

Ixodes scapularis

Black-legged tick

Isca\ISCW008568

Ixodes scapularis

Black-legged tick

Isca\ISCW019915

Ixodes scapularis

Black-legged tick

Isca\ISCW023662

Ixodes scapularis

Black-legged tick

Isca\ISCW013590

Ixodes scapularis

Black-legged tick

Isca\ISCW012169

Ixodes scapularis

Black-legged tick

Isca\ISCW012308

Ixodes scapularis

Black-legged tick

Isca\ISCW013453

Ixodes scapularis

Black-legged tick

Isca\ISCW016670

Ixodes scapularis

Black-legged tick

Isca\ISCW019922

Ixodes scapularis

Black-legged tick

Isca\ISCW019928

Stegodyphus mimosarum

African social velvet spider

Smim\KFM63060.1

Stegodyphus mimosarum

African social velvet spider

Smim\KFM72123.1

Stegodyphus mimosarum

African social velvet spider

Smim\KFM81311.1

Stegodyphus mimosarum

African social velvet spider

Smim\KFM60060.1

Stegodyphus mimosarum

African social velvet spider

Smim\KFM78383.1

Tetranychus urticae

Two-spotted spider mite

Turt\tetur22g01460

Tetranychus urticae

Two-spotted spider mite

Turt\tetur07g03340

Tetranychus urticae

Two-spotted spider mite

Turt\tetur22g01450

Tetranychus urticae

Two-spotted spider mite

Turt\tetur22g01490

Tetranychus urticae

Two-spotted spider mite

Turt\tetur08g01110

Tetranychus urticae

Two-spotted spider mite

Turt\tetur01g00020

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_316516

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_14273

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_65065

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_70078

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_28601

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_4207

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_40950

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_56750

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_4664

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_312160

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_300025

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_54448

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_192128

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_48341

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_57343

Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0QR8 )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Kirrel2L_5

Strongylocentrotus purpuratus

Purple sea urchin

Spur\SPU_022824gn

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Kirrel2L

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Igsf10L

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Kirrel2L_2

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Srcrr1

Ciona intestinalis

Vase tunicate

Cint\ENSCING00000020423

Ciona intestinalis

Vase tunicate

Cint\ENSCING00000024031

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v7.1)

Drosophila melanogaster (Fruit fly) (34)

Gene Symbol

Score

Source

Alignment

4 of 10

4 of 10

4 of 10

4 of 10

4 of 10

4 of 10

4 of 10

3 of 10

3 of 10

3 of 10

3 of 10

3 of 10

3 of 10

3 of 10

3 of 10

3 of 10

3 of 10

2 of 10

2 of 10

2 of 10

Ama

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

rst

1 of 10

Strn-Mlck

1 of 10

tutl

1 of 10

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Model Summary Ribbon

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease Associations of Human Orthologs (via DIOPT v7.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Interactions Browser

View in Interactions Browser

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

dpr15 - DIP-β

surface plasmon resonance, predetermined participant

(Cosmanescu et al., 2018)

dpr15 - DIP-γ

enzyme linked immunosorbent assay, surface plasmon resonance, predetermined participant

(Cosmanescu et al., 2018, Carrillo et al., 2015)

Summary of Genetic Interactions

esyN Network Diagram

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0037993

Pathways

Gene Group - Pathway Membership (FlyBase)

External Data

Linkouts

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

3-51

Cytogenetic map

87A10-87B1

Sequence location

3R:12,138,833..12,158,595 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

87A10-87B1

Limits computationally determined from genome sequence between P{EP}Lk6^EP886 and P{PZ}svp⁰⁷⁸⁴²

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

3-51

(FlyBase, 2016)

3-49.1

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (7)

Bloomington

25285

w¹¹¹⁸; Mi{ET1}dpr15^MB07991

34192

y¹ w^*; Mi{MIC}dpr15^MI01408

61655

y¹ w^*; Mi{PT-GFSTF.1}dpr15^{MI01408-GFSTF.1}

66827

y¹ w^*; Mi{Trojan-GAL4.1}dpr15^{MI01408-TG4.1}/TM3, Sb¹ Ser¹

VDRC

v29144

w¹¹¹⁸; P{GD14615}v29144

v46244

w¹¹¹⁸; P{GD16391}v46244

v46245

w¹¹¹⁸; P{GD16391}v46245

Genomic Clones (41)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (20)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequences

BDGP DGC clones

LP06602

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0037993

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0037993

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

41473

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Other Information

Relationship to Other Genes

Source for database identify of

Source for identity of: dpr15 CG10095

(Nakamura et al., 2002)

Source for database merge of

Additional comments

Other Comments

Origin and Etymology

Discoverer

Etymology

Identification

External Crossreferences and Linkouts ( 38 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

41473

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0037993

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0037993

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

dpr15_1

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG10095

Flygut - An atlas of the Drosophila adult midgut

FBgn0037993

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

41473

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

Dmel_CG10095

modMine - A data warehouse for the modENCODE project

FBgn0037993

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0037993

DRSC - Results frm RNAi screens

FBgn0037993

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

FBgn0037993

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

CG10095-RA

FlyMine - An integrated database for Drosophila genomics

FBgn0037993

Synonyms and Secondary IDs (6)

Reported As

Symbol Synonym

CG10095

(Hosono et al., 2015, Vogel et al., 2003, Nakamura et al., 2002)

CT28423

(Hynes and Zhao, 2000)

Dpr-15

(Vogel et al., 2003)

Dpr15

(Cosmanescu et al., 2018, Zinn and Özkan, 2017, Carrillo et al., 2015, Ozkan et al., 2013)

dpr15

(Shih et al., 2019, Lee et al., 2018, Gene Disruption Project members, 2016-, Gene Disruption Project members, 2015-, Nagarkar-Jaiswal et al., 2015, Ashwal-Fluss et al., 2014, Ozkan et al., 2013, Nakamura et al., 2002)

Name Synonyms

defective proboscis extension response 15

dpr15

Secondary FlyBase IDs

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

References (34)

Report Sections

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