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General Information
Symbol
Dmel\CG10041
Species
D. melanogaster
Name
Annotation Symbol
CG10041
Feature Type
FlyBase ID
FBgn0038014
Gene Model Status
Stock Availability
Enzyme Name (EC)
Acylaminoacyl-peptidase (3.4.19.1)
Chymotrypsin (3.4.21.1)
Acrosin (3.4.21.10)
C-terminal processing peptidase (3.4.21.102)
Cathepsin G (3.4.21.20)
Coagulation factor VIIa (3.4.21.21)
Coagulation factor IXa (3.4.21.22)
Prolyl oligopeptidase (3.4.21.26)
Coagulation factor XIa (3.4.21.27)
Plasma kallikrein (3.4.21.34)
Tissue kallikrein (3.4.21.35)
Pancreatic elastase (3.4.21.36)
Coagulation factor XIIa (3.4.21.38)
Chymase (3.4.21.39)
Trypsin (3.4.21.4)
Complement subcomponent C1r (3.4.21.41)
Complement subcomponent C1s (3.4.21.42)
Classical-complement-pathway C3/C5 convertase (3.4.21.43)
Complement factor I (3.4.21.45)
Complement factor D (3.4.21.46)
Alternative-complement-pathway C3/C5 convertase (3.4.21.47)
Cerevisin (3.4.21.48)
Thrombin (3.4.21.5)
Endopeptidase La (3.4.21.53)
Gamma-renin (3.4.21.54)
Tryptase (3.4.21.59)
Coagulation factor Xa (3.4.21.6)
Kexin (3.4.21.61)
Subtilisin (3.4.21.62)
T-plasminogen activator (3.4.21.68)
Protein C (activated) (3.4.21.69)
Plasmin (3.4.21.7)
Pancreatic elastase II (3.4.21.71)
U-plasminogen activator (3.4.21.73)
Furin (3.4.21.75)
Granzyme A (3.4.21.78)
Granzyme B (3.4.21.79)
Oligopeptidase B (3.4.21.83)
Repressor LexA (3.4.21.88)
Signal peptidase I (3.4.21.89)
Enteropeptidase (3.4.21.9)
Endopeptidase Clp (3.4.21.92)
Proprotein convertase 1 (3.4.21.93)
Proprotein convertase 2 (3.4.21.94)
Microbial collagenase (3.4.24.3)
Neutrophil collagenase (3.4.24.34)
Interstitial collagenase (3.4.24.7)
Gene Snapshot
Also Known As

SP178

Key Links
Genomic Location
Cytogenetic map
Sequence location
3R:12,350,815..12,352,103 [-]
Recombination map

3-52

RefSeq locus
NT_033777 REGION:12350815..12352103
Sequence
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (4 terms)
Molecular Function (1 term)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
inferred from electronic annotation with InterPro:IPR001254, InterPro:IPR001314, InterPro:IPR018114
(assigned by InterPro )
inferred from sequence model
Biological Process (2 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
inferred from high throughput expression pattern
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
inferred from electronic annotation with InterPro:IPR001254, InterPro:IPR001314, InterPro:IPR018114
(assigned by InterPro )
inferred from sequence model
Cellular Component (1 term)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
inferred from high throughput direct assay
Terms Based on Predictions or Assertions (0 terms)
Protein Family (UniProt)
-
Catalytic Activity (EC)
Experimental Evidence
-
Predictions / Assertions
Cleavage of an N-acetyl or N-formyl amino acid from the N-terminus of a polypeptide (3.4.19.1)
Preferential cleavage: Tyr-|-Xaa, Trp-|-Xaa, Phe-|-Xaa, Leu-|-Xaa (3.4.21.1)
Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa (3.4.21.10)
The enzyme shows specific recognition of a C-terminal tripeptide, Xaa- Yaa-Zaa, in which Xaa is preferably Ala or Leu, Yaa is preferably Ala or Tyr, and Zaa is preferably Ala, but then cleaves at a variable distance from the C-terminus (3.4.21.102)
A typical cleavage is -Ala-Ala-|-Arg-Ala-Ala- Lys-Glu-Asn-Tyr-Ala-Leu-Ala-Ala (3.4.21.102)
Specificity similar to chymotrypsin C (3.4.21.20)
Selective cleavage of Arg-|-Ile bond in factor X to form factor Xa (3.4.21.21)
Selective cleavage of Arg-|-Ile bond in factor X to form factor Xa (3.4.21.22)
Hydrolysis of Pro-|-Xaa >> Ala-|-Xaa in oligopeptides (3.4.21.26)
Selective cleavage of Arg-|-Ala and Arg-|-Val bonds in factor IX to form factor IXa (3.4.21.27)
Cleaves selectively Arg-|-Xaa and Lys-|-Xaa bonds, including Lys-|-Arg and Arg-|-Ser bonds in (human) kininogen to release bradykinin (3.4.21.34)
Preferential cleavage of Arg-|-Xaa bonds in small molecule substrates (3.4.21.35)
Highly selective action to release kallidin (lysyl-bradykinin) from kininogen involves hydrolysis of Met-|-Xaa or Leu-|-Xaa (3.4.21.35)
Hydrolysis of proteins, including elastin (3.4.21.36)
Preferential cleavage: Ala-|-Xaa (3.4.21.36)
Selective cleavage of Arg-|-Ile bonds in factor VII to form factor VIIa and factor XI to form factor XIa (3.4.21.38)
Preferential cleavage: Phe-|-Xaa > Tyr-|-Xaa > Trp-|-Xaa > Leu-|-Xaa (3.4.21.39)
Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa (3.4.21.4)
Selective cleavage of Lys(or Arg)-|-Ile bond in complement subcomponent C1s to form the active form of C1s (EC 3 (3.4.21.41)
21 (3.4.21.41)
42) (3.4.21.41)
Cleavage of Arg-|-Ala bond in complement component C4 to form C4a and C4b, and Lys(or Arg)-|-Lys bond in complement component C2 to form C2a and C2b: the 'classical' pathway C3 convertase (3.4.21.42)
Selective cleavage of Arg-|-Ser bond in complement component C3 alpha- chain to form C3a and C3b, and Arg-|-Xaa bond in complement component C5 alpha-chain to form C5a and C5b (3.4.21.43)
Inactivates complement subcomponents C3b, iC3b and C4b by proteolytic cleavage (3.4.21.45)
Selective cleavage of Arg-|-Lys bond in complement factor B when in complex with complement subcomponent C3b or with cobra venom factor (3.4.21.46)
Cleavage of Arg-|-Ser bond in complement component C3 alpha-chain to yield C3a and C3b, and Arg-|-Xaa bond in complement component C5 alpha- chain to yield C5a and C5b (3.4.21.47)
Hydrolysis of proteins with broad specificity, and of Bz-Arg-OEt > Ac-Tyr-OEt (3.4.21.48)
Does not hydrolyze peptide amides (3.4.21.48)
Selective cleavage of Arg-|-Gly bonds in fibrinogen to form fibrin and release fibrinopeptides A and B (3.4.21.5)
Hydrolysis of proteins in presence of ATP (3.4.21.53)
Cleavage of the Leu-|-Leu bond in synthetic tetradecapeptide renin substrate, to produce angiotensin I, but not active on natural angiotensinogen (3.4.21.54)
Also hydrolyzes Bz-Arg-p-nitroanilide (3.4.21.54)
Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa, but with more restricted specificity than trypsin (3.4.21.59)
Selective cleavage of Arg-|-Thr and then Arg-|-Ile bonds in prothrombin to form thrombin (3.4.21.6)
Cleavage of -Lys-Arg-|-Xaa- and -Arg-Arg-|-Xaa- bonds to process yeast alpha-factor pheromone and killer toxin precursors (3.4.21.61)
Hydrolysis of proteins with broad specificity for peptide bonds, and a preference for a large uncharged residue in P1 (3.4.21.62)
Hydrolyzes peptide amides (3.4.21.62)
Specific cleavage of Arg-|-Val bond in plasminogen to form plasmin (3.4.21.68)
Degradation of blood coagulation factors Va and VIIIa (3.4.21.69)
Preferential cleavage: Lys-|-Xaa > Arg-|-Xaa, higher selectivity than trypsin (3.4.21.7)
Converts fibrin into soluble products (3.4.21.7)
Preferential cleavage: Leu-|-Xaa, Met-|-Xaa and Phe-|-Xaa (3.4.21.71)
Hydrolyzes elastin (3.4.21.71)
Specific cleavage of Arg-|-Val bond in plasminogen to form plasmin (3.4.21.73)
Release of mature proteins from their proproteins by cleavage of -Arg- Xaa-Yaa-Arg-|-Zaa- bonds, where Xaa can be any amino acid and Yaa is Arg or Lys (3.4.21.75)
Releases albumin, complement component C3 and von Willebrand factor from their respective precursors (3.4.21.75)
Hydrolysis of proteins, including fibronectin, type IV collagen and nucleolin (3.4.21.78)
Preferential cleavage: -Arg-|-Xaa-, -Lys-|-Xaa- >> -Phe-|- Xaa- in small molecule substrates (3.4.21.78)
Preferential cleavage: -Asp-|-Xaa- >> -Asn-|-Xaa- > -Met-|-Xaa-, -Ser-|-Xaa- (3.4.21.79)
Hydrolysis of -Arg-|-Xaa- and -Lys-|-Xaa- bonds in oligopeptides, even when P1' residue is proline (3.4.21.83)
Hydrolysis of Ala-|-Gly bond in repressor LexA (3.4.21.88)
Cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic proteins (3.4.21.89)
Activation of trypsinogen by selective cleavage of 6-Lys-|-Ile-7 bond (3.4.21.9)
Hydrolysis of proteins to small peptides in the presence of ATP and magnesium (3.4.21.92)
Alpha-casein is the usual test substrate (3.4.21.92)
In the absence of ATP, only oligopeptides shorter than five residues are hydrolyzed (such as succinyl-Leu-Tyr-|-NHMec, and Leu-Tyr-Leu-|-Tyr-Trp, in which cleavage of the -Tyr-|-Leu- and -Tyr-|-Trp bonds also occurs) (3.4.21.92)
Release of protein hormones, neuropeptides and renin from their precursors, generally by hydrolysis of -Lys-Arg-|- bonds (3.4.21.93)
Release of protein hormones and neuropeptides from their precursors, generally by hydrolysis of -Lys-Arg-|- bonds (3.4.21.94)
Digestion of native collagen in the triple helical region at Xaa-|-Gly bonds (3.4.24.3)
With synthetic peptides, a preference is shown for Gly at P3 and P1', Pro and Ala at P2 and P2', and hydroxyproline, Ala or Arg at P3' (3.4.24.3)
Cleavage of interstitial collagens in the triple helical domain (3.4.24.34)
Unlike EC 3 (3.4.24.34)
24 (3.4.24.34)
7, this enzyme cleaves type III collagen more slowly than type I (3.4.24.34)
Cleavage of the triple helix of collagen at about three-quarters of the length of the molecule from the N-terminus, at 775-Gly-|-Ile-776 in the alpha-1(I) chain (3.4.24.7)
Cleaves synthetic substrates and alpha-macroglobulins at bonds where P1' is a hydrophobic residue (3.4.24.7)
Summaries
Gene Group (FlyBase)
S1A SERINE PROTEASES - CHYMOTRYPSIN-LIKE -
Chymotrypsin-like serine proteases cleave substrates following one of the hydrophobic amino acids at the P1 position. (Adapted from FBrf0239469). Chymotrypsin-like serine proteases of the S1A family are endopeptidases that cleave substrates following one of the hydrophobic amino acids at the P1 position. (Adapted from FBrf0239469).
Gene Model and Products
Number of Transcripts
1
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\CG10041 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Gene model reviewed during 5.53

Gene model reviewed during 6.23

Sequence Ontology: Class of Gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
FBtr0473577
976
287
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
FBpp0423040
32.2
287
9.86
Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\CG10041 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
inferred from high throughput direct assay
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\CG10041 in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Flygut - An atlas of the Drosophila adult midgut
Images
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 0 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 5 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of CG10041
Transgenic constructs containing regulatory region of CG10041
Deletions and Duplications ( 3 )
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
Phenotype manifest in
Allele
Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (6)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
1 of 15
Yes
Yes
1 of 15
Yes
Yes
1 of 15
Yes
Yes
1 of 15
Yes
Yes
1  
1 of 15
Yes
Yes
1 of 15
Yes
No
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (11)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
1 of 15
Yes
No
1 of 15
Yes
Yes
1 of 15
Yes
Yes
1 of 15
Yes
Yes
1 of 15
Yes
Yes
1 of 15
Yes
Yes
1 of 15
Yes
Yes
1 of 15
Yes
Yes
1 of 15
Yes
Yes
1 of 15
Yes
Yes
1 of 15
Yes
No
Rattus norvegicus (Norway rat) (6)
1 of 13
Yes
Yes
1 of 13
Yes
Yes
1 of 13
Yes
Yes
1 of 13
Yes
No
1 of 13
Yes
Yes
1 of 13
Yes
No
Xenopus tropicalis (Western clawed frog) (0)
No records found.
Danio rerio (Zebrafish) (8)
1 of 15
Yes
No
1 of 15
Yes
Yes
1 of 15
Yes
Yes
1 of 15
Yes
Yes
1 of 15
Yes
Yes
1 of 15
Yes
No
1 of 15
Yes
Yes
1 of 15
Yes
Yes
Caenorhabditis elegans (Nematode, roundworm) (1)
1 of 15
Yes
No
Arabidopsis thaliana (thale-cress) (0)
No records found.
Saccharomyces cerevisiae (Brewer's yeast) (0)
No records found.
Schizosaccharomyces pombe (Fission yeast) (0)
No records found.
Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG09190D3H )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila simulans
Drosophila sechellia
Drosophila erecta
Drosophila yakuba
Drosophila ananassae
Drosophila pseudoobscura pseudoobscura
Drosophila persimilis
Drosophila willistoni
Drosophila virilis
Drosophila mojavensis
Drosophila grimshawi
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG09150ADH )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Glossina morsitans
Tsetse fly
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( None identified )
No non-Dipteran orthologies identified
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( None identified )
No non-Insect Arthropod orthologies identified
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( None identified )
No non-Arthropod Metazoa orthologies identified
Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (38)
2 of 10
2 of 10
2 of 10
2 of 10
2 of 10
2 of 10
2 of 10
2 of 10
2 of 10
2 of 10
2 of 10
2 of 10
2 of 10
2 of 10
2 of 10
2 of 10
2 of 10
2 of 10
2 of 10
1 of 10
1 of 10
1 of 10
1 of 10
1 of 10
1 of 10
1 of 10
1 of 10
1 of 10
1 of 10
1 of 10
1 of 10
1 of 10
1 of 10
1 of 10
1 of 10
1 of 10
1 of 10
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    Functional Complementation Data
    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
    Interactions
    Summary of Physical Interactions
    esyN Network Diagram
    Interactions Browser
    Summary of Genetic Interactions
    esyN Network Diagram
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    External Data
    Linkouts
    DroID - A comprehensive database of gene and protein interactions.
    InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
    Pathways
    Signaling Pathways (FlyBase)
    Metabolic Pathways
    External Data
    Linkouts
    Genomic Location and Detailed Mapping Data
    Chromosome (arm)
    3R
    Recombination map

    3-52

    Cytogenetic map
    Sequence location
    3R:12,350,815..12,352,103 [-]
    FlyBase Computed Cytological Location
    Cytogenetic map
    Evidence for location
    87B7-87B7
    Limits computationally determined from genome sequence between P{PZ}svp07842 and P{lacW}Vha55j2E9
    Experimentally Determined Cytological Location
    Cytogenetic map
    Notes
    References
    Experimentally Determined Recombination Data
    Location
    Left of (cM)
    Right of (cM)
    Notes
    Stocks and Reagents
    Stocks (4)
    Genomic Clones (16)
     

    Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

    cDNA Clones (6)
     

    Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

    cDNA clones, fully sequenced
    BDGP DGC clones
    Other clones
    Drosophila Genomics Resource Center cDNA clones

    For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

    cDNA Clones, End Sequenced (ESTs)
    BDGP DGC clones
      RNAi and Array Information
      Linkouts
      DRSC - Results frm RNAi screens
      GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
      Antibody Information
      Laboratory Generated Antibodies
       
      Commercially Available Antibodies
       
      Other Information
      Relationship to Other Genes
      Source for database identify of
      Source for database merge of
      Additional comments
      Other Comments
      Origin and Etymology
      Discoverer
      Etymology
      Identification
      External Crossreferences and Linkouts ( 22 )
      Sequence Crossreferences
      NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
      GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
      RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
      UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
      Other crossreferences
      Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
      Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
      Flygut - An atlas of the Drosophila adult midgut
      GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
      KEGG Genes - Molecular building blocks of life in the genomic space.
      modMine - A data warehouse for the modENCODE project
      Linkouts
      DroID - A comprehensive database of gene and protein interactions.
      DRSC - Results frm RNAi screens
      FLIGHT - Cell culture data for RNAi and other high-throughput technologies
      FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
      FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
      FlyMine - An integrated database for Drosophila genomics
      InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
      Synonyms and Secondary IDs (2)
      Datasets (0)
      Study focus (0)
      Experimental Role
      Project
      Project Type
      Title
      References (26)