• Home
• Tools
  • Tools Overview
  • Query Tools

    
    • QuickSearch
    • QueryBuilder
    • TermLink
    • CytoSearch
    • Interactions Browser
    • ImageBrowse
    • Find A Person
    • Google™ FlyBase
  • Genomic/Map Tools

    
    • BLAST
    • GBrowse
    • CytoSearch
    • Aberrations Maps
    • Chromosome Maps
    • Coordinates Converter
  • Retrieve/Convert

    
    • Batch Download
    • Coordinates Converter
    • ID Converter
  • Data Submission

    
    • Fast-Track Your Paper
    • Submit Personal Comm
    • Add A New Person
    • Update Person Info
  • People

    
    • Find A Person
    • Add A New Person
    • Update Person Info
• Files
  • Files Overview
  • Downloads:
  • Precomputed files
  • Archived data
  • Releases (FTP)
  • Genomes (FTP)
  • AAA data (FTP)
  • Lists:
  • Transposons (Dmel)
  • Transposons (other)
  • Vectors & Constructs
  • Anatomical Terms
  • Map Conversion
• Species
  • Phylogeny
  • Sequenced Species
  • Synteny Table
  • Color Illustrations
  • Abbreviations
• Documents
  • About FlyBase
  • Reference Manual:
  • Sections
  • Contents
  • Nomenclature
  • Release Notes
• Resources
  • All Resources
  • Model Organisms
  • Stock Collections
  • Other links:
  • BDGP
  • DGRC
  • FlyExpress
  • Interactive Fly
  • modENCODE
  • Textpresso for Fly
• News
  • News
  • FlyBase Forum
  • FlyBase Positions
  • Meetings
  • Courses
  • Fly Board
  • White papers
  • Funding
  • bionet.dros
• Help
  • Google™ FlyBase
  • Site Map
  • FAQs
  • FlyBase Guides
  • Video Tutorials
  • Report help
  • New to Flies
  • Pers. comm.
  • Author guidelines
  • Contact FlyBase
• Archives
  • Prior Release
  • Other Archives
  • Coordinate Converter

Gene Dmel\MBD-R2

General Information
Symbol	Dmel\MBD-R2	Species	D. melanogaster
Name	MBD-R2	Annotation symbol	CG10042
Feature type	protein_coding_gene	FlyBase ID	FBgn0038016
Gene Model Status	Current	Stock availability	3 publicly available
Also Known As	dMBD-R2
Genomic Location
Chromosome (arm)	3R	Recombination map
Cytogenetic map	87B7-87B8	Sequence location	3R:8,177,865..8,182,024 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene MBD-R2 is referred to in FlyBase by the symbol Dmel\MBD-R2 (CG10042, FBgn0038016). It is a protein_coding_gene from Drosophila melanogaster. An electronic pipeline based on InterPro domains suggests that it has the molecular function: DNA binding; zinc ion binding. There is experimental evidence that it is involved in the biological process: mitotic cell cycle G2/M transition DNA damage checkpoint; neurogenesis. 5 alleles are reported. No phenotypic data is available. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: DNA-binding, integrase-type; Methyl-CpG DNA binding; Zinc finger, C2CH-type; Zinc finger, C2H2; Zinc finger, C2H2-like; Zinc finger, FYVE/PHD-type; Zinc finger, PHD-finger; Zinc finger, PHD-type; Zinc finger, PHD-type, conserved site; Zinc finger, RING/FYVE/PHD-type. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression. Peak expression observed at stages throughout embryogenesis, during early larval stages, during early pupal stages, in stages of adults of both sexes. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult hindgut, larval/adult salivary gland, larval trachea, adult ovary, adult male reproductive system. Comments on Affy2 ProbeSet: ProbeSet 1638609_s_at completely aligns to an exonic region common to each of the 2 FlyBase-annotated transcript isoforms of MBD-R2. Gene sequence location is 3R:8177865..8182024.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2011_10	Controlled Vocabulary Terms day 6 of adulthood day 5 of adulthood male day 7 of adulthood spermatozoon References Neumüller et al., 2011, Cell Stem Cell 8(5): 580--593
FB2012_01	References Dekanty et al., 2010, PLoS Genet. 6(6): e1000994 Andersen et al., 2010, Mol. Cell. Biol. 30(19): 4744--4755 Sequence features BKN21706 HFA14180
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 87B7-87B8   Limits computationally determined from genome sequence between P{PZ}svp07842 and P{lacW}Vha55j2E9
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\MBD-R2 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) MBD-R2-RA FBtr0082612  NM_141921   3698   1081 MBD-R2-RB FBtr0082611  NM_169461   3901   1169
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein MBD-R2-PA   FBpp0082082   119.9   1081   7.00     NP_650178   AAF54780 MBD-R2-PB   FBpp0082081   130.1   1169   8.11     NP_731688   AAF54781
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Methyl-CpG DNA binding (IPR001739) Zinc finger, PHD-type (IPR001965) Zinc finger, C2CH-type (IPR006612) Zinc finger, C2H2 (IPR007087) Zinc finger, C2H2-like (IPR015880) Zinc finger, FYVE/PHD-type (IPR011011) DNA-binding, integrase-type (IPR016177) Zinc finger, PHD-finger (IPR019787) Zinc finger, PHD-type, conserved site (IPR019786) Zinc finger, RING/FYVE/PHD-type (IPR013083)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014297 AAF54780   AE014297 AAF54781   AI531188   AI532392   AI542546   AI542806   AI544277   AY113647 AAM29652   BI228324   BI238355   BI361439   BI370218   BI371592   BI635040   BZ665701   CK657597   CO178914   CO262312   CO279389   CO284106   CO288369   CO291647   CO294029   CO310626   CO320954   CO321552   CO327001   CO328688   CO331469   CO341488   EC058664   EC063951   EC080576   EC085889   EC205024   EC207979   EC210152   EC224254   EC227403   EC230275   EC235263   EC239598   EC245530   EC248004   EC257163   EC257696   FE426498   FE862667   FE862726   FE863240   FE863286   GH741704   GH742453   GH743217   GH765571   GH779764   GH954015   GH956051   GH958934   GH959539   GH967808   GH972278   GH974727   GH974808   GH975161   GH975802   GH978876   GH980525   GH981116   GH981177
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q7KSN0 Q9VGA4
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 5 of adulthood & male -- day 7 of adulthood & male   spermatozoon   (Wasbrough et al., 2010)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0038016    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0038016 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression. Peak expression observed at stages throughout embryogenesis, during early larval stages, during early pupal stages, in stages of adults of both sexes. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0038016 expression level Developmental Stage   Expression Level embryo 00-02hr    3232 embryo 02-04hr    1459 embryo 04-06hr    2894 embryo 06-08hr    3139 embryo 08-10hr    2524 embryo 10-12hr    2083 embryo 12-14hr    1593 embryo 14-16hr    1430 embryo 16-18hr    1322 embryo 18-20hr    1251 embryo 20-22hr    1405 embryo 22-24hr    1423 larva L1    1436 larva L2    897 larva L3 12hr old    717 larva L3 puffstage 1-2    751 larva L3 puffstage 3-6    1215 larva L3 puffstage 7-9    1241 white prepupae new    1306 white prepupae 12hr    1551 white prepupae 24hr    1847 pupae 2d postWPP    1337 pupae 3d postWPP    960 pupae 4d postWPP    901 adult male 01day    1242 adult male 05day    1663 adult male 30day    1601 adult female 01day    1496 adult female 05day    2191 adult female 30day    2268 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (3232) embryo 02-04hr  (1459) embryo 04-06hr  (2894) embryo 06-08hr  (3139) embryo 08-10hr  (2524) embryo 10-12hr  (2083) embryo 12-14hr  (1593) embryo 14-16hr  (1430) embryo 16-18hr  (1322) embryo 18-20hr  (1251) embryo 20-22hr  (1405) embryo 22-24hr  (1423) larva L1  (1436) larva L2  (897) larva L3 12hr old  (717) larva L3 puffstage 1-2  (751) larva L3 puffstage 3-6  (1215) larva L3 puffstage 7-9  (1241) white prepupae new  (1306) white prepupae 12hr  (1551) white prepupae 24hr  (1847) pupae 2d postWPP  (1337) pupae 3d postWPP  (960) pupae 4d postWPP  (901) adult male 01day  (1242) adult male 05day  (1663) adult male 30day  (1601) adult female 01day  (1496) adult female 05day  (2191) adult female 30day  (2268) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (3232) embryo 02-04hr  1459 embryo 04-06hr  (2894) embryo 06-08hr  (3139) embryo 08-10hr  (2524) embryo 10-12hr  (2083) embryo 12-14hr  (1593) embryo 14-16hr  1430 embryo 16-18hr    1322 embryo 18-20hr    1251 embryo 20-22hr  1405 embryo 22-24hr  1423 larva L1  1436 larva L2    897 larva L3 12hr old    717 larva L3 puffstage 1-2    751 larva L3 puffstage 3-6    1215 larva L3 puffstage 7-9    1241 white prepupae new    1306 white prepupae 12hr  (1551) white prepupae 24hr  (1847) pupae 2d postWPP    1337 pupae 3d postWPP    960 pupae 4d postWPP    901 adult male 01day    1242 adult male 05day  (1663) adult male 30day  (1601) adult female 01day  1496 adult female 05day  (2191) adult female 30day  (2268) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    3232 embryo 02-04hr    1459 embryo 04-06hr    2894 embryo 06-08hr    3139 embryo 08-10hr    2524 embryo 10-12hr    2083 embryo 12-14hr    1593 embryo 14-16hr    1430 embryo 16-18hr    1322 embryo 18-20hr    1251 embryo 20-22hr    1405 embryo 22-24hr    1423 larva L1    1436 larva L2    897 larva L3 12hr old    717 larva L3 puffstage 1-2    751 larva L3 puffstage 3-6    1215 larva L3 puffstage 7-9    1241 white prepupae new    1306 white prepupae 12hr    1551 white prepupae 24hr    1847 pupae 2d postWPP    1337 pupae 3d postWPP    960 pupae 4d postWPP    901 adult male 01day    1242 adult male 05day    1663 adult male 30day    1601 adult female 01day    1496 adult female 05day    2191 adult female 30day    2268 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    3232 embryo 02-04hr    1459 embryo 04-06hr    2894 embryo 06-08hr    3139 embryo 08-10hr    2524 embryo 10-12hr    2083 embryo 12-14hr    1593 embryo 14-16hr    1430 embryo 16-18hr    1322 embryo 18-20hr    1251 embryo 20-22hr    1405 embryo 22-24hr    1423 larva L1    1436 larva L2    897 larva L3 12hr old    717 larva L3 puffstage 1-2    751 larva L3 puffstage 3-6    1215 larva L3 puffstage 7-9    1241 white prepupae new    1306 white prepupae 12hr    1551 white prepupae 24hr    1847 pupae 2d postWPP    1337 pupae 3d postWPP    960 pupae 4d postWPP    901 adult male 01day    1242 adult male 05day    1663 adult male 30day    1601 adult female 01day    1496 adult female 05day    2191 adult female 30day    2268 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0038016 expression level Developmental Stage   Expression Level embryo 00-02hr    3232 embryo 02-04hr    1459 embryo 04-06hr    2894 embryo 06-08hr    3139 embryo 08-10hr    2524 embryo 10-12hr    2083 embryo 12-14hr    1593 embryo 14-16hr    1430 embryo 16-18hr    1322 embryo 18-20hr    1251 embryo 20-22hr    1405 embryo 22-24hr    1423 larva L1    1436 larva L2    897 larva L3 12hr old    717 larva L3 puffstage 1-2    751 larva L3 puffstage 3-6    1215 larva L3 puffstage 7-9    1241 white prepupae new    1306 white prepupae 12hr    1551 white prepupae 24hr    1847 pupae 2d postWPP    1337 pupae 3d postWPP    960 pupae 4d postWPP    901 adult male 01day    1242 adult male 05day    1663 adult male 30day    1601 adult female 01day    1496 adult female 05day    2191 adult female 30day    2268 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (3232) embryo 02-04hr  (1459) embryo 04-06hr  (2894) embryo 06-08hr  (3139) embryo 08-10hr  (2524) embryo 10-12hr  (2083) embryo 12-14hr  (1593) embryo 14-16hr  (1430) embryo 16-18hr  (1322) embryo 18-20hr  (1251) embryo 20-22hr  (1405) embryo 22-24hr  (1423) larva L1  (1436) larva L2  (897) larva L3 12hr old  (717) larva L3 puffstage 1-2  (751) larva L3 puffstage 3-6  (1215) larva L3 puffstage 7-9  (1241) white prepupae new  (1306) white prepupae 12hr  (1551) white prepupae 24hr  (1847) pupae 2d postWPP  (1337) pupae 3d postWPP  (960) pupae 4d postWPP  (901) adult male 01day  (1242) adult male 05day  (1663) adult male 30day  (1601) adult female 01day  (1496) adult female 05day  (2191) adult female 30day  (2268) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (3232) embryo 02-04hr  1459 embryo 04-06hr  (2894) embryo 06-08hr  (3139) embryo 08-10hr  (2524) embryo 10-12hr  2083 embryo 12-14hr  1593 embryo 14-16hr  1430 embryo 16-18hr    1322 embryo 18-20hr    1251 embryo 20-22hr  1405 embryo 22-24hr  1423 larva L1  1436 larva L2    897 larva L3 12hr old    717 larva L3 puffstage 1-2    751 larva L3 puffstage 3-6    1215 larva L3 puffstage 7-9    1241 white prepupae new    1306 white prepupae 12hr  1551 white prepupae 24hr  1847 pupae 2d postWPP    1337 pupae 3d postWPP    960 pupae 4d postWPP    901 adult male 01day    1242 adult male 05day  1663 adult male 30day  1601 adult female 01day  1496 adult female 05day  2191 adult female 30day  2268 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    3232 embryo 02-04hr    1459 embryo 04-06hr    2894 embryo 06-08hr    3139 embryo 08-10hr    2524 embryo 10-12hr    2083 embryo 12-14hr    1593 embryo 14-16hr    1430 embryo 16-18hr    1322 embryo 18-20hr    1251 embryo 20-22hr    1405 embryo 22-24hr    1423 larva L1    1436 larva L2    897 larva L3 12hr old    717 larva L3 puffstage 1-2    751 larva L3 puffstage 3-6    1215 larva L3 puffstage 7-9    1241 white prepupae new    1306 white prepupae 12hr    1551 white prepupae 24hr    1847 pupae 2d postWPP    1337 pupae 3d postWPP    960 pupae 4d postWPP    901 adult male 01day    1242 adult male 05day    1663 adult male 30day    1601 adult female 01day    1496 adult female 05day    2191 adult female 30day    2268 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    3232 embryo 02-04hr    1459 embryo 04-06hr    2894 embryo 06-08hr    3139 embryo 08-10hr    2524 embryo 10-12hr    2083 embryo 12-14hr    1593 embryo 14-16hr    1430 embryo 16-18hr    1322 embryo 18-20hr    1251 embryo 20-22hr    1405 embryo 22-24hr    1423 larva L1    1436 larva L2    897 larva L3 12hr old    717 larva L3 puffstage 1-2    751 larva L3 puffstage 3-6    1215 larva L3 puffstage 7-9    1241 white prepupae new    1306 white prepupae 12hr    1551 white prepupae 24hr    1847 pupae 2d postWPP    1337 pupae 3d postWPP    960 pupae 4d postWPP    901 adult male 01day    1242 adult male 05day    1663 adult male 30day    1601 adult female 01day    1496 adult female 05day    2191 adult female 30day    2268 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0038016    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0038016 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult hindgut, larval/adult salivary gland, larval trachea, adult ovary, adult male reproductive system. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0038016 expression level Tissue   Expression Level Larval Central Nervous System    229.25 Larval Midgut    82.3 Larval Hindgut    104.9 Larval Malpighian Tubules    89.4 Larval Fat Body    64.5 Larval Salivary Gland    163.1 Larval Trachea    148.525 Larval Carcass    95.525 Adult Head    113.5 Adult Eye    127.075 Adult Brain    175.8 Adult Thoracic-Abdominal Ganglion    131 Adult Crop    119.8 Adult Midgut    88.1 Adult Hindgut    113.8 Adult Malpighian Tubules    76.8 Adult Fat Body    96 Adult Salivary Gland    154.4 Adult Heart    92.325 Adult VirginFemale Spermatheca    64.6 Adult InseminatedFemale Spermatheca    72 Adult Ovary    219.2 Adult Testis    199.9 Adult Male Accessory Gland    186.7 Adult Carcass    95.3 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    229.25 Larval Midgut    82.3 Larval Hindgut    104.9 Larval Malpighian Tubules    89.4 Larval Fat Body    64.5 Larval Salivary Gland    163.1 Larval Trachea    148.525 Larval Carcass    95.525 Adult Head    113.5 Adult Eye    127.075 Adult Brain    175.8 Adult Thoracic-Abdominal Ganglion    131 Adult Crop    119.8 Adult Midgut    88.1 Adult Hindgut    113.8 Adult Malpighian Tubules    76.8 Adult Fat Body    96 Adult Salivary Gland    154.4 Adult Heart    92.325 Adult VirginFemale Spermatheca    64.6 Adult InseminatedFemale Spermatheca    72 Adult Ovary    219.2 Adult Testis    199.9 Adult Male Accessory Gland    186.7 Adult Carcass    95.3 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    229.25 Larval Midgut    82.3 Larval Hindgut    104.9 Larval Malpighian Tubules    89.4 Larval Fat Body    64.5 Larval Salivary Gland    163.1 Larval Trachea    148.525 Larval Carcass    95.525 Adult Head    113.5 Adult Eye    127.075 Adult Brain    175.8 Adult Thoracic-Abdominal Ganglion    131 Adult Crop    119.8 Adult Midgut    88.1 Adult Hindgut    113.8 Adult Malpighian Tubules    76.8 Adult Fat Body    96 Adult Salivary Gland    154.4 Adult Heart    92.325 Adult VirginFemale Spermatheca    64.6 Adult InseminatedFemale Spermatheca    72 Adult Ovary    219.2 Adult Testis    199.9 Adult Male Accessory Gland    186.7 Adult Carcass    95.3 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    229.25 Larval Midgut    82.3 Larval Hindgut    104.9 Larval Malpighian Tubules    89.4 Larval Fat Body    64.5 Larval Salivary Gland    163.1 Larval Trachea    148.525 Larval Carcass    95.525 Adult Head    113.5 Adult Eye    127.075 Adult Brain    175.8 Adult Thoracic-Abdominal Ganglion    131 Adult Crop    119.8 Adult Midgut    88.1 Adult Hindgut    113.8 Adult Malpighian Tubules    76.8 Adult Fat Body    96 Adult Salivary Gland    154.4 Adult Heart    92.325 Adult VirginFemale Spermatheca    64.6 Adult InseminatedFemale Spermatheca    72 Adult Ovary    219.2 Adult Testis    199.9 Adult Male Accessory Gland    186.7 Adult Carcass    95.3 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0038016 expression level Tissue   Expression Level Larval Central Nervous System    229.25 Larval Midgut    82.3 Larval Hindgut    104.9 Larval Malpighian Tubules    89.4 Larval Fat Body    64.5 Larval Salivary Gland    163.1 Larval Trachea    148.525 Larval Carcass    95.525 Adult Head    113.5 Adult Eye    127.075 Adult Brain    175.8 Adult Thoracic-Abdominal Ganglion    131 Adult Crop    119.8 Adult Midgut    88.1 Adult Hindgut    113.8 Adult Malpighian Tubules    76.8 Adult Fat Body    96 Adult Salivary Gland    154.4 Adult Heart    92.325 Adult VirginFemale Spermatheca    64.6 Adult InseminatedFemale Spermatheca    72 Adult Ovary    219.2 Adult Testis    199.9 Adult Male Accessory Gland    186.7 Adult Carcass    95.3 Expression Level Scale  None   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    229.25 Larval Midgut    82.3 Larval Hindgut    104.9 Larval Malpighian Tubules    89.4 Larval Fat Body    64.5 Larval Salivary Gland    163.1 Larval Trachea    148.525 Larval Carcass    95.525 Adult Head    113.5 Adult Eye    127.075 Adult Brain    175.8 Adult Thoracic-Abdominal Ganglion    131 Adult Crop    119.8 Adult Midgut    88.1 Adult Hindgut    113.8 Adult Malpighian Tubules    76.8 Adult Fat Body    96 Adult Salivary Gland    154.4 Adult Heart    92.325 Adult VirginFemale Spermatheca    64.6 Adult InseminatedFemale Spermatheca    72 Adult Ovary    219.2 Adult Testis    199.9 Adult Male Accessory Gland    186.7 Adult Carcass    95.3 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    229.25 Larval Midgut    82.3 Larval Hindgut    104.9 Larval Malpighian Tubules    89.4 Larval Fat Body    64.5 Larval Salivary Gland    163.1 Larval Trachea    148.525 Larval Carcass    95.525 Adult Head    113.5 Adult Eye    127.075 Adult Brain    175.8 Adult Thoracic-Abdominal Ganglion    131 Adult Crop    119.8 Adult Midgut    88.1 Adult Hindgut    113.8 Adult Malpighian Tubules    76.8 Adult Fat Body    96 Adult Salivary Gland    154.4 Adult Heart    92.325 Adult VirginFemale Spermatheca    64.6 Adult InseminatedFemale Spermatheca    72 Adult Ovary    219.2 Adult Testis    199.9 Adult Male Accessory Gland    186.7 Adult Carcass    95.3 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    229.25 Larval Midgut    82.3 Larval Hindgut    104.9 Larval Malpighian Tubules    89.4 Larval Fat Body    64.5 Larval Salivary Gland    163.1 Larval Trachea    148.525 Larval Carcass    95.525 Adult Head    113.5 Adult Eye    127.075 Adult Brain    175.8 Adult Thoracic-Abdominal Ganglion    131 Adult Crop    119.8 Adult Midgut    88.1 Adult Hindgut    113.8 Adult Malpighian Tubules    76.8 Adult Fat Body    96 Adult Salivary Gland    154.4 Adult Heart    92.325 Adult VirginFemale Spermatheca    64.6 Adult InseminatedFemale Spermatheca    72 Adult Ovary    219.2 Adult Testis    199.9 Adult Male Accessory Gland    186.7 Adult Carcass    95.3 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    113.5   NA  Eye    127.075   NA  Brain    175.8   229.25  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    131   NA  Crop    119.8   82.3  Midgut    88.1   104.9  Hindgut    113.8   89.4  Malpighian Tubules    76.8   64.5  Fat Body    96   163.1  Salivary Gland    154.4   NA  Heart    92.325   148.525  Trachea    NA   NA  VirginFemale Spermatheca    64.6   NA  InseminatedFemale Spermatheca    72   NA  Ovary    219.2   NA  Testis    199.9   NA  Male Accessory Gland    186.7   95.525  Carcass    95.3 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_01
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0038016 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG10042-RB
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal, with Scer\GAL41407 MBD-R2GD6844 lethal | pupal stage, with Scer\GAL4pnr-MD237 MBD-R2GD6844 Other Phenotypes Allele neuroanatomy defective | larval stage, with Scer\GAL41407 MBD-R2GD6844 Phenotype manifest in Allele embryonic/larval neuroblast | larval stage, with Scer\GAL41407 MBD-R2GD6844 ganglion mother cell | larval stage, with Scer\GAL41407 MBD-R2GD6844
Classical Alleles ( 1 )
For All Classical Alleles Show
Allele of MBD-R2 Class Mutagen Stocks Known lesion MBD-R2KG09669 P-element activity 1 --
Alleles Carried on Transgenic Constructs ( 4 )
For All Alleles Carried on Transgenic Constructs Show
Allele of MBD-R2 Class Mutagen Stocks Known lesion MBD-R2HM05219 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes MBD-R2JF02351 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes MBD-R2GD6844 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes MBD-R2KK101655 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3R)Exel6164 (Ryder, 2004.4.26) Df(3R)Exel6165 (Ryder, 2004.4.26) Df(3R)Exel7314 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD6844} NA P{KK101655} NA P{TRiP.HM05219} NA P{TRiP.JF02351} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions P{SUPor-P}MBD-R2KG09669 NA
Gene Ontology: Function, Process & Cellular Component ( 6 unique terms )
Terms Based on Experimental Evidence ( 4 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
mitotic cell cycle G2/M transition DNA damage checkpoint inferred from genetic interaction with nbs (Kondo and Perrimon, 2011) neurogenesis inferred from mutant phenotype (Neumüller et al., 2011)
Cellular Component
CV term Evidence References
nucleus inferred from direct assay (Wagner et al., 2007) transcriptionally active chromatin inferred from direct assay (Prestel et al., 2010)
Terms Based on Predictions or Assertions ( 2 terms )
Molecular Function
CV term Evidence References
DNA binding inferred from electronic annotation with InterPro:IPR001739, InterPro:IPR016177 (FlyBase Curators et al., 2004-) zinc ion binding inferred from electronic annotation with InterPro:IPR001965, InterPro:IPR007087, InterPro:IPR015880 (FlyBase Curators et al., 2004-)
Biological Process ( 0 terms)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions MBD-R2 allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 66608 DroID - A comprehensive database of gene and protein interactions. • FBgn0038016 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 41498
Orthologs
Genome-wide drosophilid orthologs	Dana\GF17728 Dere\GG17141 Dgri\GH23968 Dmoj\GI10057 Dper\GL21556 Dpse\GA26332 Dsec\GM26024 Dsim\GD20581 Dvir\GJ23793 Dwil\GK11973 Dyak\GE24531
Curated drosophilid orthologs	Dpse\GA10029
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL009416-PA Aedes aegypti (mosquito) AGAP006428-PA Anopheles gambiae (mosquito) XP_001121736.1 Apis mellifera (honey bee) BGIBMGA003413-PA Bombyx mori (silk worm) ENSBTAP00000007321 Bos taurus (bovine) ENSCAFP00000001582 Canis familiaris (dog) cn07303 Cryptococcus neoformans (yeast-like fungus) CPIJ004606 Culex pipens (mosquito) ENSCPOP00000001840 Cavia porcellus (guinea pig) 222293 Capitella spl (polychaete worm) 302349 Daphnia pulex (daphnia) ENSDARP00000056569 Danio rerio (zebra fish) ENSECAP00000022405 Equus caballus (horse) ENSGACP00000000643 Gymnopilus aculeatus (mushroom) ENSGALP00000002312 Gallus gallus (chicken) ENSP00000363124 Homo sapiens (human) ISCW002283-PA Ixodes scapularis (deer tick) ENSMODP00000004224 Monodelphis domestica (gray opossum) ENSMMUP00000037841 Macaca mulatta (rhesus monkey) ENSMUSP00000085969 Mus musculus (house mouse) XP_001602338.1 Nasonia vitripennis (wasp) ENSOANP00000015959 Ornithorynchus anatinus (platypus) ENSORLP00000023681 Oryzias latipes (japanese killifish) ENSPPYP00000012242 Pongo pygmaeus (orangutan) ENSPTRP00000023083 Pan troglodytes (chimpanzee) ENSRNOP00000044547 Rattus norvegicus (norway rat) XP_972506.1 Tribolium castaneum (red flour beetle) ENSTNIP00000010110 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000024227 Takifugu rubripes (pufferfish Takifugu) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB16778 NV13885 LH12880 ISCW002283 FBgn0241644 FBgn0213984 FBgn0210889 FBgn0192048 FBgn0180879 JGI_V11_302349 FBgn0247706 FBgn0159149 FBgn0132823 FBgn0131425 FBgn0109368 FBgn0094746 CPIJ004606 BGIBMGA003413 ACYPI002280 GB15775 AGAP006428 AAEL009416 PHUM440050 GLEAN_10453
Stocks & Reagents
Stocks Listed in FlyBase ( 3 )
Bloomington	27029 y1 v1; P{TRiP.JF02351}attP2 30481 y1 sc* v1; P{TRiP.HM05219}attP2 15204 y1; P{SUPor-P}MBD-R2KG09669 ry506/TM3, Sb1 Ser1
Genomic Clones ( 1 )
	BACR44K17 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 66 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	SD10773
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	LP24022 RE25839 RE34763 RE45650 RE56663 RE58517 SD01905 SD02124 SD03893 SD08901 SD09271
Other clones	20161 46704 61128 66179 73687 76350 99393 174948 193773 214283.57 214371.54 272621 CK01.40D.F2 CK01.73C.A6 CK01.86C.D6 CK01.100D.F9 EK057935 EK068347 EK085023 EK134217 EK165251 EK185918 EK197904 EK205532 EK222153 EK289401 EK291206 EK299860 EP05430 EP12536 RM05213 RM06013 RM06113 RM06313 RM06413 RP001006037 RP001006401 RP001021721 RP001037886 RP001046980 RP004018520 RP004086778 RP004121224 RP004233502 RP004236486 RP004240475 RP004255520 RP004333878 RP004349244 RP004355582 RP004358522 RP004399861 RP004462741 RP004556864
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0038016 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 41498
Antibody Information
	polyclonal (Prestel et al., 2010, Raja et al., 2010)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: MBD-R2 CG10042 (Rasheva, 2003.2.11)
Source for database merge of	Source for merge of: MBD-R2 CG17393 (FlyBase, 1996-)
Additional comments	Source for merge of MBD-R2 CG17393 was sequence comparison (date:001104). (FlyBase, 1996-)
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_141921 NM_169461 RefSeq (Proteins) • NP_650178 NP_731688 DDBJ / EMBL / GenBank • AAF54780 AAF54781 AAM29652 AI544277 AY113647 BZ665701 Entrez Gene - A searchable database of RefSeq genes. • 41498 UniProtKB/TrEMBL • Q7KSN0 Q9VGA4
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Methyl-CpG DNA binding (IPR001739) Zinc finger, PHD-type (IPR001965) Zinc finger, C2CH-type (IPR006612) Zinc finger, C2H2 (IPR007087) Zinc finger, C2H2-like (IPR015880) Zinc finger, FYVE/PHD-type (IPR011011) DNA-binding, integrase-type (IPR016177) Zinc finger, PHD-finger (IPR019787) Zinc finger, PHD-type, conserved site (IPR019786) Zinc finger, RING/FYVE/PHD-type (IPR013083)
Linkouts
	BioGRID - A database of protein and genetic interactions • 66608 DroID - A comprehensive database of gene and protein interactions. • FBgn0038016 DRSC - Results from RNAi screens. • FBgn0038016 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0038016 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG10042-RB FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0038016 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 41498 InParanoid A subset of ortholog calls from InParanoid. • AAEL009416-PA Aedes aegypti (mosquito) AGAP006428-PA Anopheles gambiae (mosquito) XP_001121736.1 Apis mellifera (honey bee) BGIBMGA003413-PA Bombyx mori (silk worm) ENSBTAP00000007321 Bos taurus (bovine) ENSCAFP00000001582 Canis familiaris (dog) cn07303 Cryptococcus neoformans (yeast-like fungus) CPIJ004606 Culex pipens (mosquito) ENSCPOP00000001840 Cavia porcellus (guinea pig) 222293 Capitella spl (polychaete worm) 302349 Daphnia pulex (daphnia) ENSDARP00000056569 Danio rerio (zebra fish) ENSECAP00000022405 Equus caballus (horse) ENSGACP00000000643 Gymnopilus aculeatus (mushroom) ENSGALP00000002312 Gallus gallus (chicken) ENSP00000363124 Homo sapiens (human) ISCW002283-PA Ixodes scapularis (deer tick) ENSMODP00000004224 Monodelphis domestica (gray opossum) ENSMMUP00000037841 Macaca mulatta (rhesus monkey) ENSMUSP00000085969 Mus musculus (house mouse) XP_001602338.1 Nasonia vitripennis (wasp) ENSOANP00000015959 Ornithorynchus anatinus (platypus) ENSORLP00000023681 Oryzias latipes (japanese killifish) ENSPPYP00000012242 Pongo pygmaeus (orangutan) ENSPTRP00000023083 Pan troglodytes (chimpanzee) ENSRNOP00000044547 Rattus norvegicus (norway rat) XP_972506.1 Tribolium castaneum (red flour beetle) ENSTNIP00000010110 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000024227 Takifugu rubripes (pufferfish Takifugu) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 41498 modMine - Data generated by the modENCODE project. • FBgn0038016 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB16778 NV13885 LH12880 ISCW002283 FBgn0241644 FBgn0213984 FBgn0210889 FBgn0192048 FBgn0180879 JGI_V11_302349 FBgn0247706 FBgn0159149 FBgn0132823 FBgn0131425 FBgn0109368 FBgn0094746 CPIJ004606 BGIBMGA003413 ACYPI002280 GB15775 AGAP006428 AAEL009416 PHUM440050 GLEAN_10453
Synonyms & Secondary IDs ( 9 )
Reported As
Symbol Synonym	CG10042 (Robertson, 2001.1.8, Giot et al., 2003, Bienz, 2006, Wagner et al., 2007, Perkins et al., 2009, Perkins et al., 2009.3.31, Raja et al., 2010, Keleman et al., 2009.8.5) CG17393   dMBD-R2 (Rasheva et al., 2004, Rasheva et al., 2003, Wagner et al., 2007) Dm Tam3 (Hendrich and Tweedie, 2003) MBD (Eggert et al., 2005) MBD-R2 (Mendjan et al., 2006, Bienz, 2006, White et al., 2011, Wagner et al., 2007, Prestel et al., 2010, Raja et al., 2010, Kondo and Perrimon, 2011, Wasbrough et al., 2010, Neumüller et al., 2011, Dekanty et al., 2010) MBDR2 (Wagner et al., 2007) mbd-R2 (Andersen et al., 2010) TAM3 (Hendrich and Tweedie, 2003)
Name Synonym	MBD-R2 (Raja et al., 2010)
Secondary FlyBase IDs
	FBgn0038015
References ( 34 )
Generate a list of	All references relating to this gene ( 34 )
List References by type	Research paper  ( 9 ) Supplementary material  ( 6 ) Review  ( 2 ) Personal communication to FlyBase  ( 8 ) Abstract  ( 4 ) FlyBase analysis  ( 2 ) Computer file  ( 2 ) Automatic genome annotation  ( 1 )
Recent research papers ( 7 )
	Kondo and Perrimon, 2011, Sci. Signal. 4(154): rs1 A Genome-Wide RNAi Screen Identifies Core Components of the G2-M DNA Damage Checkpoint. [FBrf0212700] Neumüller et al., 2011, Cell Stem Cell 8(5): 580--593 Genome-Wide Analysis of Self-Renewal in Drosophila Neural Stem Cells by Transgenic RNAi. [FBrf0213621] White et al., 2011, J. Cell Biol. 193(4): 677--694 Drosophila histone locus bodies form by hierarchical recruitment of components. [FBrf0213662] Andersen et al., 2010, Mol. Cell. Biol. 30(19): 4744--4755 Drosophila MCRS2 Associates with RNA Polymerase II Complexes To Regulate Transcription. [FBrf0211794] Dekanty et al., 2010, PLoS Genet. 6(6): e1000994 Drosophila Genome-Wide RNAi Screen Identifies Multiple Regulators of HIF-Dependent Transcription in Hypoxia. [FBrf0211155] Prestel et al., 2010, Mol. Cell 38(6): 815--826 The Activation Potential of MOF Is Constrained for Dosage Compensation. [FBrf0211211] Raja et al., 2010, Mol. Cell 38(6): 827--841 The Nonspecific Lethal Complex Is a Transcriptional Regulator in Drosophila. [FBrf0211222] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...