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Gene Dmel\Sas

General Information
Symbol	Dmel\Sas	Species	D. melanogaster
Name	Sialic acid phosphate synthase	Annotation symbol	CG5232
Feature type	protein_coding_gene	FlyBase ID	FBgn0038045
Gene Model Status	Current	Stock availability	4 publicly available
Also Known As	Neu5Ac
Genomic Location
Chromosome (arm)	3R	Recombination map
Cytogenetic map	87B10-87B10	Sequence location	3R:8,252,300..8,253,599 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Sialic acid phosphate synthase is referred to in FlyBase by the symbol Dmel\Sas (CG5232, FBgn0038045). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: N-acylneuraminate-9-phosphate synthase activity. An electronic pipeline based on InterPro domains suggests that it is involved in the biological process: carbohydrate biosynthetic process. 4 alleles are reported. The phenotype of these alleles is annotated with: mesothoracic tergum. It has one annotated transcript and one annotated polypeptide. Protein features are: Aldolase-type TIM barrel; Antifreeze-like/N-acetylneuraminic acid synthase C-terminal; N-acetylneuraminic acid synthase, N-terminal; SAF domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of low expression to a trough of extremely low expression. Peak expression observed within 06-24 hour embryonic stages, during early larval stages, during early pupal stages. Summary of FlyAtlas Anatomical Expression Data: Little or no expression detected in any larval or adult organs/tissues. Comments on Affy2 ProbeSet: ProbeSet 1639936_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of Sas. Gene sequence location is 3R:8252300..8253599.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2011_10
FB2012_01	Sequence features HFA15743 BKN22230
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 87B10-87B10   Limits computationally determined from genome sequence between P{PZ}svp07842 and P{lacW}Vha55j2E9
Experimentally Determined Cytological Location
Cytogenetic map Notes References 87B15-87B15     (Kim, 2001.7.9)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Sas for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Sas-RA FBtr0082588  NM_141938   1194   372
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Sas-PA   FBpp0082060   41.2   372   6.35     NP_650195   AAF54811
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Antifreeze-like/N-acetylneuraminic acid synthase C-terminal (IPR006190) N-acetylneuraminic acid synthase, N-terminal (IPR013132) Aldolase-type TIM barrel (IPR013785) SAF domain (IPR013974)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014297 AAF54811   AF397531 AAK92125   BT032769   CZ471077
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9VG74
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0038045    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0038045 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of low expression to a trough of extremely low expression. Peak expression observed within 06-24 hour embryonic stages, during early larval stages, during early pupal stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0038045 expression level Developmental Stage   Expression Level embryo 00-02hr    4 embryo 02-04hr    4 embryo 04-06hr    12 embryo 06-08hr    34 embryo 08-10hr    26 embryo 10-12hr    128 embryo 12-14hr    198 embryo 14-16hr    172 embryo 16-18hr    186 embryo 18-20hr    91 embryo 20-22hr    92 embryo 22-24hr    101 larva L1    171 larva L2    111 larva L3 12hr old    46 larva L3 puffstage 1-2    44 larva L3 puffstage 3-6    59 larva L3 puffstage 7-9    73 white prepupae new    60 white prepupae 12hr    101 white prepupae 24hr    82 pupae 2d postWPP    100 pupae 3d postWPP    94 pupae 4d postWPP    16 adult male 01day    40 adult male 05day    42 adult male 30day    34 adult female 01day    14 adult female 05day    12 adult female 30day    6 Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr    4 embryo 02-04hr    4 embryo 04-06hr    12 embryo 06-08hr    34 embryo 08-10hr    26 embryo 10-12hr  (128) embryo 12-14hr  (198) embryo 14-16hr  (172) embryo 16-18hr  (186) embryo 18-20hr    91 embryo 20-22hr    92 embryo 22-24hr  101 larva L1  (171) larva L2  (111) larva L3 12hr old    46 larva L3 puffstage 1-2    44 larva L3 puffstage 3-6    59 larva L3 puffstage 7-9    73 white prepupae new    60 white prepupae 12hr  101 white prepupae 24hr    82 pupae 2d postWPP    100 pupae 3d postWPP    94 pupae 4d postWPP    16 adult male 01day    40 adult male 05day    42 adult male 30day    34 adult female 01day    14 adult female 05day    12 adult female 30day    6 Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    4 embryo 02-04hr    4 embryo 04-06hr    12 embryo 06-08hr    34 embryo 08-10hr    26 embryo 10-12hr    128 embryo 12-14hr    198 embryo 14-16hr    172 embryo 16-18hr    186 embryo 18-20hr    91 embryo 20-22hr    92 embryo 22-24hr    101 larva L1    171 larva L2    111 larva L3 12hr old    46 larva L3 puffstage 1-2    44 larva L3 puffstage 3-6    59 larva L3 puffstage 7-9    73 white prepupae new    60 white prepupae 12hr    101 white prepupae 24hr    82 pupae 2d postWPP    100 pupae 3d postWPP    94 pupae 4d postWPP    16 adult male 01day    40 adult male 05day    42 adult male 30day    34 adult female 01day    14 adult female 05day    12 adult female 30day    6 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    4 embryo 02-04hr    4 embryo 04-06hr    12 embryo 06-08hr    34 embryo 08-10hr    26 embryo 10-12hr    128 embryo 12-14hr    198 embryo 14-16hr    172 embryo 16-18hr    186 embryo 18-20hr    91 embryo 20-22hr    92 embryo 22-24hr    101 larva L1    171 larva L2    111 larva L3 12hr old    46 larva L3 puffstage 1-2    44 larva L3 puffstage 3-6    59 larva L3 puffstage 7-9    73 white prepupae new    60 white prepupae 12hr    101 white prepupae 24hr    82 pupae 2d postWPP    100 pupae 3d postWPP    94 pupae 4d postWPP    16 adult male 01day    40 adult male 05day    42 adult male 30day    34 adult female 01day    14 adult female 05day    12 adult female 30day    6 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    4 embryo 02-04hr    4 embryo 04-06hr    12 embryo 06-08hr    34 embryo 08-10hr    26 embryo 10-12hr    128 embryo 12-14hr    198 embryo 14-16hr    172 embryo 16-18hr    186 embryo 18-20hr    91 embryo 20-22hr    92 embryo 22-24hr    101 larva L1    171 larva L2    111 larva L3 12hr old    46 larva L3 puffstage 1-2    44 larva L3 puffstage 3-6    59 larva L3 puffstage 7-9    73 white prepupae new    60 white prepupae 12hr    101 white prepupae 24hr    82 pupae 2d postWPP    100 pupae 3d postWPP    94 pupae 4d postWPP    16 adult male 01day    40 adult male 05day    42 adult male 30day    34 adult female 01day    14 adult female 05day    12 adult female 30day    6 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0038045 expression level Developmental Stage   Expression Level embryo 00-02hr    4 embryo 02-04hr    4 embryo 04-06hr    12 embryo 06-08hr    34 embryo 08-10hr    26 embryo 10-12hr    128 embryo 12-14hr    198 embryo 14-16hr    172 embryo 16-18hr    186 embryo 18-20hr    91 embryo 20-22hr    92 embryo 22-24hr    101 larva L1    171 larva L2    111 larva L3 12hr old    46 larva L3 puffstage 1-2    44 larva L3 puffstage 3-6    59 larva L3 puffstage 7-9    73 white prepupae new    60 white prepupae 12hr    101 white prepupae 24hr    82 pupae 2d postWPP    100 pupae 3d postWPP    94 pupae 4d postWPP    16 adult male 01day    40 adult male 05day    42 adult male 30day    34 adult female 01day    14 adult female 05day    12 adult female 30day    6 Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr    4 embryo 02-04hr    4 embryo 04-06hr    12 embryo 06-08hr    34 embryo 08-10hr    26 embryo 10-12hr  128 embryo 12-14hr  (198) embryo 14-16hr  (172) embryo 16-18hr  (186) embryo 18-20hr    91 embryo 20-22hr    92 embryo 22-24hr  101 larva L1  (171) larva L2  111 larva L3 12hr old    46 larva L3 puffstage 1-2    44 larva L3 puffstage 3-6    59 larva L3 puffstage 7-9    73 white prepupae new    60 white prepupae 12hr  101 white prepupae 24hr    82 pupae 2d postWPP    100 pupae 3d postWPP    94 pupae 4d postWPP    16 adult male 01day    40 adult male 05day    42 adult male 30day    34 adult female 01day    14 adult female 05day    12 adult female 30day    6 Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    4 embryo 02-04hr    4 embryo 04-06hr    12 embryo 06-08hr    34 embryo 08-10hr    26 embryo 10-12hr    128 embryo 12-14hr    198 embryo 14-16hr    172 embryo 16-18hr    186 embryo 18-20hr    91 embryo 20-22hr    92 embryo 22-24hr    101 larva L1    171 larva L2    111 larva L3 12hr old    46 larva L3 puffstage 1-2    44 larva L3 puffstage 3-6    59 larva L3 puffstage 7-9    73 white prepupae new    60 white prepupae 12hr    101 white prepupae 24hr    82 pupae 2d postWPP    100 pupae 3d postWPP    94 pupae 4d postWPP    16 adult male 01day    40 adult male 05day    42 adult male 30day    34 adult female 01day    14 adult female 05day    12 adult female 30day    6 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    4 embryo 02-04hr    4 embryo 04-06hr    12 embryo 06-08hr    34 embryo 08-10hr    26 embryo 10-12hr    128 embryo 12-14hr    198 embryo 14-16hr    172 embryo 16-18hr    186 embryo 18-20hr    91 embryo 20-22hr    92 embryo 22-24hr    101 larva L1    171 larva L2    111 larva L3 12hr old    46 larva L3 puffstage 1-2    44 larva L3 puffstage 3-6    59 larva L3 puffstage 7-9    73 white prepupae new    60 white prepupae 12hr    101 white prepupae 24hr    82 pupae 2d postWPP    100 pupae 3d postWPP    94 pupae 4d postWPP    16 adult male 01day    40 adult male 05day    42 adult male 30day    34 adult female 01day    14 adult female 05day    12 adult female 30day    6 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    4 embryo 02-04hr    4 embryo 04-06hr    12 embryo 06-08hr    34 embryo 08-10hr    26 embryo 10-12hr    128 embryo 12-14hr    198 embryo 14-16hr    172 embryo 16-18hr    186 embryo 18-20hr    91 embryo 20-22hr    92 embryo 22-24hr    101 larva L1    171 larva L2    111 larva L3 12hr old    46 larva L3 puffstage 1-2    44 larva L3 puffstage 3-6    59 larva L3 puffstage 7-9    73 white prepupae new    60 white prepupae 12hr    101 white prepupae 24hr    82 pupae 2d postWPP    100 pupae 3d postWPP    94 pupae 4d postWPP    16 adult male 01day    40 adult male 05day    42 adult male 30day    34 adult female 01day    14 adult female 05day    12 adult female 30day    6 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0038045    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0038045 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Little or no expression detected in any larval or adult organs/tissues. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0038045 expression level Tissue   Expression Level Larval Central Nervous System    84.25 Larval Midgut    5.4 Larval Hindgut    3.1 Larval Malpighian Tubules    4.7 Larval Fat Body    2.9 Larval Salivary Gland    8.3 Larval Trachea    4.675 Larval Carcass    3.625 Adult Head no informative data Adult Eye    4.725 Adult Brain    40.9 Adult Thoracic-Abdominal Ganglion    59.6 Adult Crop    4.4 Adult Midgut    3.7 Adult Hindgut    5.7 Adult Malpighian Tubules    2.9 Adult Fat Body    4.9 Adult Salivary Gland    6.2 Adult Heart    3.075 Adult VirginFemale Spermatheca    3.2 Adult InseminatedFemale Spermatheca    2.8 Adult Ovary    2.1 Adult Testis    6.6 Adult Male Accessory Gland    9.1 Adult Carcass    2.5 Expression Level Scale  None   Low  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    84.25 Larval Midgut    5.4 Larval Hindgut    3.1 Larval Malpighian Tubules    4.7 Larval Fat Body    2.9 Larval Salivary Gland    8.3 Larval Trachea    4.675 Larval Carcass    3.625 Adult Head no informative data Adult Eye    4.725 Adult Brain    40.9 Adult Thoracic-Abdominal Ganglion    59.6 Adult Crop    4.4 Adult Midgut    3.7 Adult Hindgut    5.7 Adult Malpighian Tubules    2.9 Adult Fat Body    4.9 Adult Salivary Gland    6.2 Adult Heart    3.075 Adult VirginFemale Spermatheca    3.2 Adult InseminatedFemale Spermatheca    2.8 Adult Ovary    2.1 Adult Testis    6.6 Adult Male Accessory Gland    9.1 Adult Carcass    2.5 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    84.25 Larval Midgut    5.4 Larval Hindgut    3.1 Larval Malpighian Tubules    4.7 Larval Fat Body    2.9 Larval Salivary Gland    8.3 Larval Trachea    4.675 Larval Carcass    3.625 Adult Head no informative data Adult Eye    4.725 Adult Brain    40.9 Adult Thoracic-Abdominal Ganglion    59.6 Adult Crop    4.4 Adult Midgut    3.7 Adult Hindgut    5.7 Adult Malpighian Tubules    2.9 Adult Fat Body    4.9 Adult Salivary Gland    6.2 Adult Heart    3.075 Adult VirginFemale Spermatheca    3.2 Adult InseminatedFemale Spermatheca    2.8 Adult Ovary    2.1 Adult Testis    6.6 Adult Male Accessory Gland    9.1 Adult Carcass    2.5 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    84.25 Larval Midgut    5.4 Larval Hindgut    3.1 Larval Malpighian Tubules    4.7 Larval Fat Body    2.9 Larval Salivary Gland    8.3 Larval Trachea    4.675 Larval Carcass    3.625 Adult Head no informative data Adult Eye    4.725 Adult Brain    40.9 Adult Thoracic-Abdominal Ganglion    59.6 Adult Crop    4.4 Adult Midgut    3.7 Adult Hindgut    5.7 Adult Malpighian Tubules    2.9 Adult Fat Body    4.9 Adult Salivary Gland    6.2 Adult Heart    3.075 Adult VirginFemale Spermatheca    3.2 Adult InseminatedFemale Spermatheca    2.8 Adult Ovary    2.1 Adult Testis    6.6 Adult Male Accessory Gland    9.1 Adult Carcass    2.5 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0038045 expression level Tissue   Expression Level Larval Central Nervous System    84.25 Larval Midgut    5.4 Larval Hindgut    3.1 Larval Malpighian Tubules    4.7 Larval Fat Body    2.9 Larval Salivary Gland    8.3 Larval Trachea    4.675 Larval Carcass    3.625 Adult Head no informative data Adult Eye    4.725 Adult Brain    40.9 Adult Thoracic-Abdominal Ganglion    59.6 Adult Crop    4.4 Adult Midgut    3.7 Adult Hindgut    5.7 Adult Malpighian Tubules    2.9 Adult Fat Body    4.9 Adult Salivary Gland    6.2 Adult Heart    3.075 Adult VirginFemale Spermatheca    3.2 Adult InseminatedFemale Spermatheca    2.8 Adult Ovary    2.1 Adult Testis    6.6 Adult Male Accessory Gland    9.1 Adult Carcass    2.5 Expression Level Scale  None   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    84.25 Larval Midgut    5.4 Larval Hindgut    3.1 Larval Malpighian Tubules    4.7 Larval Fat Body    2.9 Larval Salivary Gland    8.3 Larval Trachea    4.675 Larval Carcass    3.625 Adult Head no informative data Adult Eye    4.725 Adult Brain    40.9 Adult Thoracic-Abdominal Ganglion    59.6 Adult Crop    4.4 Adult Midgut    3.7 Adult Hindgut    5.7 Adult Malpighian Tubules    2.9 Adult Fat Body    4.9 Adult Salivary Gland    6.2 Adult Heart    3.075 Adult VirginFemale Spermatheca    3.2 Adult InseminatedFemale Spermatheca    2.8 Adult Ovary    2.1 Adult Testis    6.6 Adult Male Accessory Gland    9.1 Adult Carcass    2.5 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    84.25 Larval Midgut    5.4 Larval Hindgut    3.1 Larval Malpighian Tubules    4.7 Larval Fat Body    2.9 Larval Salivary Gland    8.3 Larval Trachea    4.675 Larval Carcass    3.625 Adult Head no informative data Adult Eye    4.725 Adult Brain    40.9 Adult Thoracic-Abdominal Ganglion    59.6 Adult Crop    4.4 Adult Midgut    3.7 Adult Hindgut    5.7 Adult Malpighian Tubules    2.9 Adult Fat Body    4.9 Adult Salivary Gland    6.2 Adult Heart    3.075 Adult VirginFemale Spermatheca    3.2 Adult InseminatedFemale Spermatheca    2.8 Adult Ovary    2.1 Adult Testis    6.6 Adult Male Accessory Gland    9.1 Adult Carcass    2.5 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    84.25 Larval Midgut    5.4 Larval Hindgut    3.1 Larval Malpighian Tubules    4.7 Larval Fat Body    2.9 Larval Salivary Gland    8.3 Larval Trachea    4.675 Larval Carcass    3.625 Adult Head no informative data Adult Eye    4.725 Adult Brain    40.9 Adult Thoracic-Abdominal Ganglion    59.6 Adult Crop    4.4 Adult Midgut    3.7 Adult Hindgut    5.7 Adult Malpighian Tubules    2.9 Adult Fat Body    4.9 Adult Salivary Gland    6.2 Adult Heart    3.075 Adult VirginFemale Spermatheca    3.2 Adult InseminatedFemale Spermatheca    2.8 Adult Ovary    2.1 Adult Testis    6.6 Adult Male Accessory Gland    9.1 Adult Carcass    2.5 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head no informative data Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    no informative data   NA  Eye    4.725   NA  Brain    40.9   84.25  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    59.6   NA  Crop    4.4   5.4  Midgut    3.7   3.1  Hindgut    5.7   4.7  Malpighian Tubules    2.9   2.9  Fat Body    4.9   8.3  Salivary Gland    6.2   NA  Heart    3.075   4.675  Trachea    NA   NA  VirginFemale Spermatheca    3.2   NA  InseminatedFemale Spermatheca    2.8   NA  Ovary    2.1   NA  Testis    6.6   NA  Male Accessory Gland    9.1   3.625  Carcass    2.5 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_29
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0038045 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG5232-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele semi-lethal | pupal stage, with Scer\GAL4pnr-MD237 SasGD11586 Other Phenotypes Allele visible, with Scer\GAL4pnr-MD237 SasGD11586 Phenotype manifest in Allele mesothoracic tergum, with Scer\GAL4pnr-MD237 SasGD11586
Classical Alleles ( 1 )
For All Classical Alleles Show
Allele of Sas Class Mutagen Stocks Known lesion Sasc06915 piggyBac transposase 0 --
Alleles Carried on Transgenic Constructs ( 3 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Sas Class Mutagen Stocks Known lesion SasGD11586 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes SasHMS01346 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes SasKK102164 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes
Aneuploid Aberrations
Disrupted in	Df(3R)Exel6164 (Ryder, 2004.4.26) Df(3R)Exel6165 (Ryder, 2004.4.26) Df(3R)Exel7316 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD11586} NA P{KK102164} NA P{TRiP.HMS01346} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions PBac{PB}Sasc06915 NA
Gene Ontology: Function, Process & Cellular Component ( 2 unique terms )
Terms Based on Experimental Evidence ( 1 term )
Molecular Function
CV term Evidence References
N-acylneuraminate-9-phosphate synthase activity inferred from direct assay (Kim et al., 2002)
Biological Process ( 0 terms)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 2 terms )
Molecular Function
CV term Evidence References
N-acylneuraminate-9-phosphate synthase activity non-traceable author statement (Kim, 2001.7.9)
Biological Process
CV term Evidence References
carbohydrate biosynthetic process inferred from electronic annotation with InterPro:IPR013132 (FlyBase Curators et al., 2004-)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Sas allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 66626 DroID - A comprehensive database of gene and protein interactions. • FBgn0038045 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 41528
Orthologs
Genome-wide drosophilid orthologs	Dana\GF17956 Dere\GG18905 Dgri\GH13892 Dmoj\GI24828 Dper\GL27311 Dpse\GA18754 Dsec\GM24031 Dsim\GD18832 Dvir\GJ24471 Dwil\GK14403 Dyak\GE26192
Curated drosophilid orthologs	Dpse\GA18754
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL000097-PA Aedes aegypti (mosquito) AGAP004460-PA Anopheles gambiae (mosquito) XP_001951662.1 Acyrthosiphon pisum (pea aphid) 115797 Branchiostoma floridae (lancelet) BGIBMGA002651-PA Bombyx mori (silk worm) ENSBTAP00000025318 Bos taurus (bovine) ENSCAFP00000003592 Canis familiaris (dog) CPIJ013964 Culex pipens (mosquito) ENSCPOP00000001174 Cavia porcellus (guinea pig) 300651 Daphnia pulex (daphnia) ENSDARP00000067085 Danio rerio (zebra fish) ENSECAP00000014323 Equus caballus (horse) ENSGACP00000024614 Gymnopilus aculeatus (mushroom) ENSGALP00000037043 Gallus gallus (chicken) ENSP00000210444 Homo sapiens (human) ENSMODP00000003993 Monodelphis domestica (gray opossum) ENSMUSP00000030018 Mus musculus (house mouse) ENSOANP00000017638 Ornithorynchus anatinus (platypus) ENSORLP00000025775 Oryzias latipes (japanese killifish) PHUM006120-PA Pediculus humanus (human body louse) ENSPPYP00000021774 Pongo pygmaeus (orangutan) ENSPTRP00000036182 Pan troglodytes (chimpanzee) ENSRNOP00000012260 Rattus norvegicus (norway rat) XP_001194550.1 Strongylocentrotus purpuratus (purple sea urchin) ENSTNIP00000021237 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000039754 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000014349 Xenopus tropicalis (frog) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • FBgn0243227 FBgn0216409 FBgn0211551 FBgn0190348 FBgn0178896 JGI_V11_300651 FBgn0078754 FBgn0164892 FBgn0147549 FBgn0121368 FBgn0111112 FBgn0094974 CPIJ013964 BGIBMGA002651 ACYPI007229 AGAP004460 AAEL000097 PHUM018360 GLEAN_00193
Stocks & Reagents
Stocks Listed in FlyBase ( 4 )
Bloomington	34357 y1 sc* v1; P{TRiP.HMS01346}attP2/TM3, Sb1
VDRC	v103919 P{KK102164}VIE-260B v22040 w1118; P{GD11586}v22040 v22041 w1118; P{GD11586}v22041
Genomic Clones ( 1 )
	BACR28I14 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 1 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones
Other clones	IP20889
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones
Other clones
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0038045 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 41528
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: Neu5Ac CG5232 (FlyBase, 1996-)
Source for database merge of
Additional comments	Source for identity of Neu5Ac CG5232 was sequence comparison (date:010908). (FlyBase, 1996-)
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_141938 RefSeq (Proteins) • NP_650195 DDBJ / EMBL / GenBank • AAF54811 AAK92125 AF397531 CZ471077 Entrez Gene - A searchable database of RefSeq genes. • 41528 UniProtKB/TrEMBL • Q9VG74
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Antifreeze-like/N-acetylneuraminic acid synthase C-terminal (IPR006190) N-acetylneuraminic acid synthase, N-terminal (IPR013132) Aldolase-type TIM barrel (IPR013785) SAF domain (IPR013974)
Linkouts
	BioGRID - A database of protein and genetic interactions • 66626 DroID - A comprehensive database of gene and protein interactions. • FBgn0038045 DRSC - Results from RNAi screens. • FBgn0038045 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0038045 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG5232-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0038045 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 41528 InParanoid A subset of ortholog calls from InParanoid. • AAEL000097-PA Aedes aegypti (mosquito) AGAP004460-PA Anopheles gambiae (mosquito) XP_001951662.1 Acyrthosiphon pisum (pea aphid) 115797 Branchiostoma floridae (lancelet) BGIBMGA002651-PA Bombyx mori (silk worm) ENSBTAP00000025318 Bos taurus (bovine) ENSCAFP00000003592 Canis familiaris (dog) CPIJ013964 Culex pipens (mosquito) ENSCPOP00000001174 Cavia porcellus (guinea pig) 300651 Daphnia pulex (daphnia) ENSDARP00000067085 Danio rerio (zebra fish) ENSECAP00000014323 Equus caballus (horse) ENSGACP00000024614 Gymnopilus aculeatus (mushroom) ENSGALP00000037043 Gallus gallus (chicken) ENSP00000210444 Homo sapiens (human) ENSMODP00000003993 Monodelphis domestica (gray opossum) ENSMUSP00000030018 Mus musculus (house mouse) ENSOANP00000017638 Ornithorynchus anatinus (platypus) ENSORLP00000025775 Oryzias latipes (japanese killifish) PHUM006120-PA Pediculus humanus (human body louse) ENSPPYP00000021774 Pongo pygmaeus (orangutan) ENSPTRP00000036182 Pan troglodytes (chimpanzee) ENSRNOP00000012260 Rattus norvegicus (norway rat) XP_001194550.1 Strongylocentrotus purpuratus (purple sea urchin) ENSTNIP00000021237 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000039754 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000014349 Xenopus tropicalis (frog) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 41528 modMine - Data generated by the modENCODE project. • FBgn0038045 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • FBgn0243227 FBgn0216409 FBgn0211551 FBgn0190348 FBgn0178896 JGI_V11_300651 FBgn0078754 FBgn0164892 FBgn0147549 FBgn0121368 FBgn0111112 FBgn0094974 CPIJ013964 BGIBMGA002651 ACYPI007229 AGAP004460 AAEL000097 PHUM018360 GLEAN_00193
Synonyms & Secondary IDs ( 10 )
Reported As
Symbol Synonym	CG5232 (Kim et al., 2002, Keleman et al., 2009.8.5, Ni et al., 2010.12.1) DmSAS (Kim et al., 2002) Neu5Ac (Fabini and Wilson, 2001, Giot et al., 2003, ) Sas (Geng and MacDonald, 2007) SAS (Campbell et al., 2009) sas (Greenberg et al., 2006)
Name Synonym	N-acetylneuraminic acid phosphate synthase (Kim et al., 2001) Neu5Ac synthase (Kim, 2001.7.9) Sialic acid phosphate synthase (Kim et al., 2002) sialic acid synthase (Akan et al., 2007)
Secondary FlyBase IDs
References ( 19 )
Research paper	Campbell et al., 2009, J. Cell Sci. 122(15): 2604--2612 Crumbs stabilises epithelial polarity during tissue remodelling. [FBrf0208408] Geng and MacDonald, 2007, Fly 1(5): 259--267 Identification of genes that influence gurken expression. [FBrf0205043] Greenberg et al., 2006, Molec. Biol. Evol. 23(2): 401--410 Adaptive loss of an old duplicated gene during incipient speciation. [FBrf0191173] Kim et al., 2002, Glycobiology 12(2): 73--83 Expression of a functional Drosophila melanogaster N-acetylneuraminic acid (Neu5Ac) phosphate synthase gene: evidence for endogenous sialic acid biosynthetic ability in insects. [FBrf0147072] Fabini and Wilson, 2001, D. I. S. 84: 122--129 Glycosyltransferases in Drosophila melanogaster. [FBrf0150727]
Supplementary material	The modENCODE Consortium, 2010, Science 330(6012): DataS14: Gene co-expression clusters. [FBrf0213979] Mummery-Widmer et al., 2009, Nature 458(7241): Supplementary Table 2 - Genome-wide bristle screen results. [FBrf0214518] Giot et al., 2003, Science 302(5651): Tables S1 to S7. [FBrf0166452]
Personal communication to FlyBase	Ni et al., 2010.12.1, A genome-scale shRNA resource for transgenic RNAi in Drosophila. A genome-scale shRNA resource for transgenic RNAi in Drosophila. [FBrf0212437] Keleman et al., 2009.8.5, RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0208510] Dickson et al., 2007.7.18, RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0200327] FlyBase Curators et al., 2004-, Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. [FBrf0174215] Ryder, 2004.4.26, Exelixis CG deletion data. Exelixis CG deletion data. [FBrf0184335]
Abstract	Akan et al., 2007, A. Dros. Res. Conf. 48: 576C The Drosophila sialylation genes are expressed in a subset of neurons during embryonic development. [FBrf0198495] Kim et al., 2001, Molec. Biol. Cell 12(Suppl.): 506a Expression of a functional Drosophila melanogaster N-acetylneuraminic acid (Neu5Ac) phosphate synthase gene provides evidence that insects have endogenous sialic acid biosynthetic ability. [FBrf0145101]
FlyBase analysis	FlyBase, 1996-, FlyBase inference based on genome sequence analysis. FlyBase inference based on genome sequence analysis. [FBrf0104946]
DNA/RNA sequence record	Kim, 2001.7.9, GenBank/EMBL/DDBJ: AF397531 Drosophila melanogaster Neu5Ac synthase mRNA, complete cds. [FBrf0138689]
Computer file	Gene Disruption Project members and Exelixis, 2005, Genomic mapping of Exelixis insertion collection. Genomic mapping of Exelixis insertion collection. [FBrf0184340] Gene Disruption Project members, 2001-, [title not yet available] [title not yet available] [FBrf0132177]