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Gene Dmel\CG5641

General Information
Symbol	Dmel\CG5641	Species	D. melanogaster
Name		Annotation symbol	CG5641
Feature type	protein_coding_gene	FlyBase ID	FBgn0038046
Gene Model Status	Current	Stock availability	6 publicly available
Genomic Location
Chromosome (arm)	3R	Recombination map
Cytogenetic map	87B10-87B10	Sequence location	3R:8,253,515..8,255,002 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	This gene is referred to in FlyBase by the symbol Dmel\CG5641 (FBgn0038046). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: DNA binding; double-stranded RNA binding. Based on sequence similarity, it is predicted to be involved in the biological process: positive regulation of transcription, DNA-dependent. 4 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: 2-5-oligoadenylate synthetase, N-terminal; DZF. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-12 hour embryonic stages, during early pupal stages. Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: larval central nervous system. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, adult central nervous system, larval hindgut, larval Malpighian tubules, larval fat body, larval salivary gland, larval trachea, adult ovary, adult male reproductive system, larval carcass. Comments on Affy2 ProbeSet: ProbeSet 1627873_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of CG5641. Gene sequence location is 3R:8253515..8255002.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2011_10
FB2012_01	Sequence features HFA15852 BKN28375
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 87B10-87B10   Limits computationally determined from genome sequence between P{PZ}svp07842 and P{lacW}Vha55j2E9
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\CG5641 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) CG5641-RA FBtr0082594  NM_141939   1365   396
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein CG5641-PA   FBpp0082066   43.7   396   6.93     NP_650196   AAF54812
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • 2-5-oligoadenylate synthetase, N-terminal (IPR006116) DZF (IPR006561)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA801873   AE014297 AAF54812   AI389034   AI403153   AI405540   AI944651   AW940981   AY051610 AAK93034   BI228998   BI232053   BI232301   BI233221   BI352034   BI352194   BI354013   BI354494   BI614337   BI615242   BI615879   BI621545   BI624458   BI626431   BI628519   BI634961   CO264487   EC236340   EC267152   EL877233   EL883765   FD585835   FD586544   FD586554   FD586572   FD587273   FD587298   GH742278
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9VG73
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0038046    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0038046 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-12 hour embryonic stages, during early pupal stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0038046 expression level Developmental Stage   Expression Level embryo 00-02hr    6653 embryo 02-04hr    3710 embryo 04-06hr    5335 embryo 06-08hr    6679 embryo 08-10hr    5081 embryo 10-12hr    5395 embryo 12-14hr    2724 embryo 14-16hr    3119 embryo 16-18hr    1631 embryo 18-20hr    1035 embryo 20-22hr    669 embryo 22-24hr    593 larva L1    1585 larva L2    1619 larva L3 12hr old    1583 larva L3 puffstage 1-2    1887 larva L3 puffstage 3-6    2667 larva L3 puffstage 7-9    2675 white prepupae new    2948 white prepupae 12hr    3563 white prepupae 24hr    4630 pupae 2d postWPP    2863 pupae 3d postWPP    1711 pupae 4d postWPP    1630 adult male 01day    1893 adult male 05day    2594 adult male 30day    2570 adult female 01day    2984 adult female 05day    3767 adult female 30day    3933 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (6653) embryo 02-04hr  (3710) embryo 04-06hr  (5335) embryo 06-08hr  (6679) embryo 08-10hr  (5081) embryo 10-12hr  (5395) embryo 12-14hr  (2724) embryo 14-16hr  (3119) embryo 16-18hr  (1631) embryo 18-20hr  (1035) embryo 20-22hr  (669) embryo 22-24hr  (593) larva L1  (1585) larva L2  (1619) larva L3 12hr old  (1583) larva L3 puffstage 1-2  (1887) larva L3 puffstage 3-6  (2667) larva L3 puffstage 7-9  (2675) white prepupae new  (2948) white prepupae 12hr  (3563) white prepupae 24hr  (4630) pupae 2d postWPP  (2863) pupae 3d postWPP  (1711) pupae 4d postWPP  (1630) adult male 01day  (1893) adult male 05day  (2594) adult male 30day  (2570) adult female 01day  (2984) adult female 05day  (3767) adult female 30day  (3933) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (6653) embryo 02-04hr  (3710) embryo 04-06hr  (5335) embryo 06-08hr  (6679) embryo 08-10hr  (5081) embryo 10-12hr  (5395) embryo 12-14hr  (2724) embryo 14-16hr  (3119) embryo 16-18hr  (1631) embryo 18-20hr    1035 embryo 20-22hr    669 embryo 22-24hr    593 larva L1  (1585) larva L2  (1619) larva L3 12hr old  (1583) larva L3 puffstage 1-2  (1887) larva L3 puffstage 3-6  (2667) larva L3 puffstage 7-9  (2675) white prepupae new  (2948) white prepupae 12hr  (3563) white prepupae 24hr  (4630) pupae 2d postWPP  (2863) pupae 3d postWPP  (1711) pupae 4d postWPP  (1630) adult male 01day  (1893) adult male 05day  (2594) adult male 30day  (2570) adult female 01day  (2984) adult female 05day  (3767) adult female 30day  (3933) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    6653 embryo 02-04hr    3710 embryo 04-06hr    5335 embryo 06-08hr    6679 embryo 08-10hr    5081 embryo 10-12hr    5395 embryo 12-14hr    2724 embryo 14-16hr    3119 embryo 16-18hr    1631 embryo 18-20hr    1035 embryo 20-22hr    669 embryo 22-24hr    593 larva L1    1585 larva L2    1619 larva L3 12hr old    1583 larva L3 puffstage 1-2    1887 larva L3 puffstage 3-6    2667 larva L3 puffstage 7-9    2675 white prepupae new    2948 white prepupae 12hr    3563 white prepupae 24hr    4630 pupae 2d postWPP    2863 pupae 3d postWPP    1711 pupae 4d postWPP    1630 adult male 01day    1893 adult male 05day    2594 adult male 30day    2570 adult female 01day    2984 adult female 05day    3767 adult female 30day    3933 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    6653 embryo 02-04hr    3710 embryo 04-06hr    5335 embryo 06-08hr    6679 embryo 08-10hr    5081 embryo 10-12hr    5395 embryo 12-14hr    2724 embryo 14-16hr    3119 embryo 16-18hr    1631 embryo 18-20hr    1035 embryo 20-22hr    669 embryo 22-24hr    593 larva L1    1585 larva L2    1619 larva L3 12hr old    1583 larva L3 puffstage 1-2    1887 larva L3 puffstage 3-6    2667 larva L3 puffstage 7-9    2675 white prepupae new    2948 white prepupae 12hr    3563 white prepupae 24hr    4630 pupae 2d postWPP    2863 pupae 3d postWPP    1711 pupae 4d postWPP    1630 adult male 01day    1893 adult male 05day    2594 adult male 30day    2570 adult female 01day    2984 adult female 05day    3767 adult female 30day    3933 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0038046 expression level Developmental Stage   Expression Level embryo 00-02hr    6653 embryo 02-04hr    3710 embryo 04-06hr    5335 embryo 06-08hr    6679 embryo 08-10hr    5081 embryo 10-12hr    5395 embryo 12-14hr    2724 embryo 14-16hr    3119 embryo 16-18hr    1631 embryo 18-20hr    1035 embryo 20-22hr    669 embryo 22-24hr    593 larva L1    1585 larva L2    1619 larva L3 12hr old    1583 larva L3 puffstage 1-2    1887 larva L3 puffstage 3-6    2667 larva L3 puffstage 7-9    2675 white prepupae new    2948 white prepupae 12hr    3563 white prepupae 24hr    4630 pupae 2d postWPP    2863 pupae 3d postWPP    1711 pupae 4d postWPP    1630 adult male 01day    1893 adult male 05day    2594 adult male 30day    2570 adult female 01day    2984 adult female 05day    3767 adult female 30day    3933 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (6653) embryo 02-04hr  (3710) embryo 04-06hr  (5335) embryo 06-08hr  (6679) embryo 08-10hr  (5081) embryo 10-12hr  (5395) embryo 12-14hr  (2724) embryo 14-16hr  (3119) embryo 16-18hr  (1631) embryo 18-20hr  (1035) embryo 20-22hr  (669) embryo 22-24hr  (593) larva L1  (1585) larva L2  (1619) larva L3 12hr old  (1583) larva L3 puffstage 1-2  (1887) larva L3 puffstage 3-6  (2667) larva L3 puffstage 7-9  (2675) white prepupae new  (2948) white prepupae 12hr  (3563) white prepupae 24hr  (4630) pupae 2d postWPP  (2863) pupae 3d postWPP  (1711) pupae 4d postWPP  (1630) adult male 01day  (1893) adult male 05day  (2594) adult male 30day  (2570) adult female 01day  (2984) adult female 05day  (3767) adult female 30day  (3933) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (6653) embryo 02-04hr  (3710) embryo 04-06hr  (5335) embryo 06-08hr  (6679) embryo 08-10hr  (5081) embryo 10-12hr  (5395) embryo 12-14hr  (2724) embryo 14-16hr  (3119) embryo 16-18hr  1631 embryo 18-20hr    1035 embryo 20-22hr    669 embryo 22-24hr    593 larva L1  1585 larva L2  1619 larva L3 12hr old  1583 larva L3 puffstage 1-2  1887 larva L3 puffstage 3-6  (2667) larva L3 puffstage 7-9  (2675) white prepupae new  (2948) white prepupae 12hr  (3563) white prepupae 24hr  (4630) pupae 2d postWPP  (2863) pupae 3d postWPP  1711 pupae 4d postWPP  1630 adult male 01day  1893 adult male 05day  (2594) adult male 30day  (2570) adult female 01day  (2984) adult female 05day  (3767) adult female 30day  (3933) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    6653 embryo 02-04hr    3710 embryo 04-06hr    5335 embryo 06-08hr    6679 embryo 08-10hr    5081 embryo 10-12hr    5395 embryo 12-14hr    2724 embryo 14-16hr    3119 embryo 16-18hr    1631 embryo 18-20hr    1035 embryo 20-22hr    669 embryo 22-24hr    593 larva L1    1585 larva L2    1619 larva L3 12hr old    1583 larva L3 puffstage 1-2    1887 larva L3 puffstage 3-6    2667 larva L3 puffstage 7-9    2675 white prepupae new    2948 white prepupae 12hr    3563 white prepupae 24hr    4630 pupae 2d postWPP    2863 pupae 3d postWPP    1711 pupae 4d postWPP    1630 adult male 01day    1893 adult male 05day    2594 adult male 30day    2570 adult female 01day    2984 adult female 05day    3767 adult female 30day    3933 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    6653 embryo 02-04hr    3710 embryo 04-06hr    5335 embryo 06-08hr    6679 embryo 08-10hr    5081 embryo 10-12hr    5395 embryo 12-14hr    2724 embryo 14-16hr    3119 embryo 16-18hr    1631 embryo 18-20hr    1035 embryo 20-22hr    669 embryo 22-24hr    593 larva L1    1585 larva L2    1619 larva L3 12hr old    1583 larva L3 puffstage 1-2    1887 larva L3 puffstage 3-6    2667 larva L3 puffstage 7-9    2675 white prepupae new    2948 white prepupae 12hr    3563 white prepupae 24hr    4630 pupae 2d postWPP    2863 pupae 3d postWPP    1711 pupae 4d postWPP    1630 adult male 01day    1893 adult male 05day    2594 adult male 30day    2570 adult female 01day    2984 adult female 05day    3767 adult female 30day    3933 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0038046    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0038046 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: larval central nervous system. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, adult central nervous system, larval hindgut, larval Malpighian tubules, larval fat body, larval salivary gland, larval trachea, adult ovary, adult male reproductive system, larval carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0038046 expression level Tissue   Expression Level Larval Central Nervous System    518.1 Larval Midgut    74.8 Larval Hindgut    137.5 Larval Malpighian Tubules    131.2 Larval Fat Body    131.7 Larval Salivary Gland    251.5 Larval Trachea    192.45 Larval Carcass    132.175 Adult Head    132.7 Adult Eye    291.1 Adult Brain    206.9 Adult Thoracic-Abdominal Ganglion    173.3 Adult Crop    77.1 Adult Midgut    82.8 Adult Hindgut    86.5 Adult Malpighian Tubules    61.9 Adult Fat Body    88.2 Adult Salivary Gland    83.5 Adult Heart    87.375 Adult VirginFemale Spermatheca    69.2 Adult InseminatedFemale Spermatheca    72.2 Adult Ovary    233.8 Adult Testis    234.9 Adult Male Accessory Gland    163.8 Adult Carcass    86.5 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  518.1 Larval Midgut    74.8 Larval Hindgut    137.5 Larval Malpighian Tubules    131.2 Larval Fat Body    131.7 Larval Salivary Gland    251.5 Larval Trachea    192.45 Larval Carcass    132.175 Adult Head    132.7 Adult Eye    291.1 Adult Brain    206.9 Adult Thoracic-Abdominal Ganglion    173.3 Adult Crop    77.1 Adult Midgut    82.8 Adult Hindgut    86.5 Adult Malpighian Tubules    61.9 Adult Fat Body    88.2 Adult Salivary Gland    83.5 Adult Heart    87.375 Adult VirginFemale Spermatheca    69.2 Adult InseminatedFemale Spermatheca    72.2 Adult Ovary    233.8 Adult Testis    234.9 Adult Male Accessory Gland    163.8 Adult Carcass    86.5 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    518.1 Larval Midgut    74.8 Larval Hindgut    137.5 Larval Malpighian Tubules    131.2 Larval Fat Body    131.7 Larval Salivary Gland    251.5 Larval Trachea    192.45 Larval Carcass    132.175 Adult Head    132.7 Adult Eye    291.1 Adult Brain    206.9 Adult Thoracic-Abdominal Ganglion    173.3 Adult Crop    77.1 Adult Midgut    82.8 Adult Hindgut    86.5 Adult Malpighian Tubules    61.9 Adult Fat Body    88.2 Adult Salivary Gland    83.5 Adult Heart    87.375 Adult VirginFemale Spermatheca    69.2 Adult InseminatedFemale Spermatheca    72.2 Adult Ovary    233.8 Adult Testis    234.9 Adult Male Accessory Gland    163.8 Adult Carcass    86.5 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    518.1 Larval Midgut    74.8 Larval Hindgut    137.5 Larval Malpighian Tubules    131.2 Larval Fat Body    131.7 Larval Salivary Gland    251.5 Larval Trachea    192.45 Larval Carcass    132.175 Adult Head    132.7 Adult Eye    291.1 Adult Brain    206.9 Adult Thoracic-Abdominal Ganglion    173.3 Adult Crop    77.1 Adult Midgut    82.8 Adult Hindgut    86.5 Adult Malpighian Tubules    61.9 Adult Fat Body    88.2 Adult Salivary Gland    83.5 Adult Heart    87.375 Adult VirginFemale Spermatheca    69.2 Adult InseminatedFemale Spermatheca    72.2 Adult Ovary    233.8 Adult Testis    234.9 Adult Male Accessory Gland    163.8 Adult Carcass    86.5 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0038046 expression level Tissue   Expression Level Larval Central Nervous System    518.1 Larval Midgut    74.8 Larval Hindgut    137.5 Larval Malpighian Tubules    131.2 Larval Fat Body    131.7 Larval Salivary Gland    251.5 Larval Trachea    192.45 Larval Carcass    132.175 Adult Head    132.7 Adult Eye    291.1 Adult Brain    206.9 Adult Thoracic-Abdominal Ganglion    173.3 Adult Crop    77.1 Adult Midgut    82.8 Adult Hindgut    86.5 Adult Malpighian Tubules    61.9 Adult Fat Body    88.2 Adult Salivary Gland    83.5 Adult Heart    87.375 Adult VirginFemale Spermatheca    69.2 Adult InseminatedFemale Spermatheca    72.2 Adult Ovary    233.8 Adult Testis    234.9 Adult Male Accessory Gland    163.8 Adult Carcass    86.5 Expression Level Scale  None   Low   Moderate   High  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  518.1 Larval Midgut    74.8 Larval Hindgut    137.5 Larval Malpighian Tubules    131.2 Larval Fat Body    131.7 Larval Salivary Gland    251.5 Larval Trachea    192.45 Larval Carcass    132.175 Adult Head    132.7 Adult Eye    291.1 Adult Brain    206.9 Adult Thoracic-Abdominal Ganglion    173.3 Adult Crop    77.1 Adult Midgut    82.8 Adult Hindgut    86.5 Adult Malpighian Tubules    61.9 Adult Fat Body    88.2 Adult Salivary Gland    83.5 Adult Heart    87.375 Adult VirginFemale Spermatheca    69.2 Adult InseminatedFemale Spermatheca    72.2 Adult Ovary    233.8 Adult Testis    234.9 Adult Male Accessory Gland    163.8 Adult Carcass    86.5 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    518.1 Larval Midgut    74.8 Larval Hindgut    137.5 Larval Malpighian Tubules    131.2 Larval Fat Body    131.7 Larval Salivary Gland    251.5 Larval Trachea    192.45 Larval Carcass    132.175 Adult Head    132.7 Adult Eye    291.1 Adult Brain    206.9 Adult Thoracic-Abdominal Ganglion    173.3 Adult Crop    77.1 Adult Midgut    82.8 Adult Hindgut    86.5 Adult Malpighian Tubules    61.9 Adult Fat Body    88.2 Adult Salivary Gland    83.5 Adult Heart    87.375 Adult VirginFemale Spermatheca    69.2 Adult InseminatedFemale Spermatheca    72.2 Adult Ovary    233.8 Adult Testis    234.9 Adult Male Accessory Gland    163.8 Adult Carcass    86.5 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    518.1 Larval Midgut    74.8 Larval Hindgut    137.5 Larval Malpighian Tubules    131.2 Larval Fat Body    131.7 Larval Salivary Gland    251.5 Larval Trachea    192.45 Larval Carcass    132.175 Adult Head    132.7 Adult Eye    291.1 Adult Brain    206.9 Adult Thoracic-Abdominal Ganglion    173.3 Adult Crop    77.1 Adult Midgut    82.8 Adult Hindgut    86.5 Adult Malpighian Tubules    61.9 Adult Fat Body    88.2 Adult Salivary Gland    83.5 Adult Heart    87.375 Adult VirginFemale Spermatheca    69.2 Adult InseminatedFemale Spermatheca    72.2 Adult Ovary    233.8 Adult Testis    234.9 Adult Male Accessory Gland    163.8 Adult Carcass    86.5 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    132.7   NA  Eye    291.1   NA  Brain    206.9   518.1  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    173.3   NA  Crop    77.1   74.8  Midgut    82.8   137.5  Hindgut    86.5   131.2  Malpighian Tubules    61.9   131.7  Fat Body    88.2   251.5  Salivary Gland    83.5   NA  Heart    87.375   192.45  Trachea    NA   NA  VirginFemale Spermatheca    69.2   NA  InseminatedFemale Spermatheca    72.2   NA  Ovary    233.8   NA  Testis    234.9   NA  Male Accessory Gland    163.8   132.175  Carcass    86.5 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_06
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0038046 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG5641-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for CG5641 Stages(s) 1-3 Stages(s) 4-6 Stages(s) 7-8 Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable, with Scer\GAL4pnr-MD237 CG5641GD11716 CG5641GD16764 Phenotype manifest in Allele
Classical Alleles ( 1 )
For All Classical Alleles Show
Allele of CG5641 Class Mutagen Stocks Known lesion CG5641NP2255 1 --
Alleles Carried on Transgenic Constructs ( 3 )
For All Alleles Carried on Transgenic Constructs Show
Allele of CG5641 Class Mutagen Stocks Known lesion CG5641GD11716 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes CG5641GD16764 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes CG5641KK108375 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes
Aneuploid Aberrations
Disrupted in	Df(3R)Exel6164 (Ryder, 2004.4.26) Df(3R)Exel6165 (Ryder, 2004.4.26) Df(3R)Exel7316 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD11716} NA P{GD16764} NA P{KK108375} NA
Insertions
	Type of insertions Name Expression data insertion of enhancer trap binary system P{GawB}CG5641NP2255 No
Gene Ontology: Function, Process & Cellular Component ( 11 unique terms )
Terms Based on Experimental Evidence ( 2 terms )
Molecular Function ( 0 terms)
Biological Process ( 0 terms)
Cellular Component
CV term Evidence References
catalytic step 2 spliceosome inferred from direct assay (Herold et al., 2009) precatalytic spliceosome inferred from direct assay (Herold et al., 2009)
Terms Based on Predictions or Assertions ( 9 terms )
Molecular Function
CV term Evidence References
ATP binding inferred from electronic annotation with InterPro:IPR006116 (FlyBase Curators et al., 2004-) DNA binding inferred from sequence or structural similarity with UniProtKB:Q12905 (assigned by UniProtKB) (GOA Curators et al., 2007) double-stranded RNA binding inferred from sequence or structural similarity with UniProtKB:Q12905 (assigned by UniProtKB) (GOA Curators et al., 2007) transferase activity inferred from electronic annotation with InterPro:IPR006116 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
immune response inferred from electronic annotation with InterPro:IPR006116 (FlyBase Curators et al., 2004-) nuclear mRNA splicing, via spliceosome inferred by curator from GO:0071011|GO:0071013 (Herold et al., 2009) positive regulation of transcription, DNA-dependent inferred from sequence or structural similarity with UniProtKB:Q12905 (assigned by UniProtKB) (FBrf0198850, GOA Curators et al., 2007)
Cellular Component
CV term Evidence References
nucleolus inferred from sequence or structural similarity with UniProtKB:Q12905 (assigned by UniProtKB) (GOA Curators et al., 2007) nucleus inferred from sequence or structural similarity with UniProtKB:Q12905 (assigned by UniProtKB) (GOA Curators et al., 2007)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions CG5641 allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 66627 DroID - A comprehensive database of gene and protein interactions. • FBgn0038046 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 41529
Orthologs
Genome-wide drosophilid orthologs	Dana\GF17043 Dere\GG17126 Dgri\GH17463 Dmoj\GI22787 Dper\GL27175 Dpse\GA19024 Dsec\GM26008 Dsim\GD20566 Dvir\GJ22789 Dwil\GK12843 Dyak\GE24517
Curated drosophilid orthologs	Dpse\GA19024
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL006048-PA Aedes aegypti (mosquito) AGAP001997-PA Anopheles gambiae (mosquito) XP_624830.1 Apis mellifera (honey bee) XP_001952312.1 Acyrthosiphon pisum (pea aphid) 279457 Branchiostoma floridae (lancelet) XP_001894513.1 Brugia malayi (roundworm nematode) BGIBMGA009554-PA Bombyx mori (silk worm) ENSBTAP00000016549 Bos taurus (bovine) CN10565 Caenorhabditis brenneri (small nematode) CBP30522 Caenorhabditis briggsae (nematode) CE12778 Caenorhabditis elegans (worm) ENSCAFP00000025827 Canis familiaris (dog) ENSCINP00000007077 Ciona intestinalis (sea squirt) ENSCPOP00000005263 Cavia porcellus (guinea pig) RP13585 Caenorhabditis remanei (nematode) ENSCSAVP00000012018 Ciona savignyi (sedentary tunicate) 148485 Capitella spl (polychaete worm) 304101 Daphnia pulex (daphnia) ENSDARP00000022486 Danio rerio (zebra fish) ENSECAP00000006934 Equus caballus (horse) ENSGACP00000000720 Gymnopilus aculeatus (mushroom) ENSGALP00000018849 Gallus gallus (chicken) 185807 Hypsipyla robusta (cedar shoot borer) ENSP00000355011 Homo sapiens (human) ISCW017579-PA Ixodes scapularis (deer tick) 117522 Lottia gigantea (owl limpet) ENSMODP00000021687 Monodelphis domestica (gray opossum) ENSMMUP00000010668 Macaca mulatta (rhesus monkey) ENSMUSP00000001042 Mus musculus (house mouse) 123730 Nematostella vectensis (starlet anemone) XP_001607450.1 Nasonia vitripennis (wasp) ENSOANP00000018820 Ornithorynchus anatinus (platypus) ENSORLP00000013739 Oryzias latipes (japanese killifish) PHUM004839-PA Pediculus humanus (human body louse) PP19716 Pristionchus pacificus (nematode) ENSPPYP00000000934 Pongo pygmaeus (orangutan) ENSPTRP00000002286 Pan troglodytes (chimpanzee) ENSRNOP00000045539 Rattus norvegicus (norway rat) Smp_141000 Schistosoma mansoni (trematode parasite) XP_001176545.1 Strongylocentrotus purpuratus (purple sea urchin) XP_001201253.1 Strongylocentrotus purpuratus (purple sea urchin) 52288 Trichoplax adhaerens (metazoa) XP_968185.1 Tribolium castaneum (red flour beetle) ENSTNIP00000007671 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000011665 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000031274 Xenopus tropicalis (frog) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV10830 LH16668 ISCW017579 FBgn0241631 FBgn0214852 FBgn0209893 FBgn0192034 FBgn0180864 JGI_V11_304101 FBgn0079022 FBgn0164756 FBgn0145514 FBgn0124933 FBgn0109354 FBgn0094062 CPIJ006945 BGIBMGA009554 ACYPI007293 GB13665 AGAP001997 AAEL015636 AAEL006048 PB22537 PHUM361360 GLEAN_04865
Stocks & Reagents
Stocks Listed in FlyBase ( 6 )
Kyoto	104141 w*; P{GawB}CG5641NP2255 / TM3, Sb1 Ser1
VDRC	v101343 P{KK108375}VIE-260B v42042 w1118 P{GD11716}v42042 v42043 w1118 P{GD11716}v42043 v48200 w1118; P{GD16764}v48200 v48201 w1118; P{GD16764}v48201
Genomic Clones ( 1 )
	BACR28I14 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 32 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GH25564
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH20112 GH22536 GM03517 GM17303 GM27037 RE26681 RE28056 RE28347 RE29515 RH39944 RH43691 RH44827 RH45768 RH52902 RH56951 RH64021 RH67372
Other clones	82358 572804 EK139402 GM18269 GM25951 IP07172 IP13423 RM02622 RM02822 RM02922 RM03022 RM03122 RM03222 RP001012996
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0038046 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 41529
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_141939 RefSeq (Proteins) • NP_650196 DDBJ / EMBL / GenBank • AAF54812 AAK93034 AI405540 AI944651 AW940981 AY051610 Entrez Gene - A searchable database of RefSeq genes. • 41529 UniProtKB/TrEMBL • Q9VG73
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • 2-5-oligoadenylate synthetase, N-terminal (IPR006116) DZF (IPR006561)
Linkouts
	BioGRID - A database of protein and genetic interactions • 66627 DroID - A comprehensive database of gene and protein interactions. • FBgn0038046 DRSC - Results from RNAi screens. • FBgn0038046 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0038046 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG5641-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0038046 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 41529 InParanoid A subset of ortholog calls from InParanoid. • AAEL006048-PA Aedes aegypti (mosquito) AGAP001997-PA Anopheles gambiae (mosquito) XP_624830.1 Apis mellifera (honey bee) XP_001952312.1 Acyrthosiphon pisum (pea aphid) 279457 Branchiostoma floridae (lancelet) XP_001894513.1 Brugia malayi (roundworm nematode) BGIBMGA009554-PA Bombyx mori (silk worm) ENSBTAP00000016549 Bos taurus (bovine) CN10565 Caenorhabditis brenneri (small nematode) CBP30522 Caenorhabditis briggsae (nematode) CE12778 Caenorhabditis elegans (worm) ENSCAFP00000025827 Canis familiaris (dog) ENSCINP00000007077 Ciona intestinalis (sea squirt) ENSCPOP00000005263 Cavia porcellus (guinea pig) RP13585 Caenorhabditis remanei (nematode) ENSCSAVP00000012018 Ciona savignyi (sedentary tunicate) 148485 Capitella spl (polychaete worm) 304101 Daphnia pulex (daphnia) ENSDARP00000022486 Danio rerio (zebra fish) ENSECAP00000006934 Equus caballus (horse) ENSGACP00000000720 Gymnopilus aculeatus (mushroom) ENSGALP00000018849 Gallus gallus (chicken) 185807 Hypsipyla robusta (cedar shoot borer) ENSP00000355011 Homo sapiens (human) ISCW017579-PA Ixodes scapularis (deer tick) 117522 Lottia gigantea (owl limpet) ENSMODP00000021687 Monodelphis domestica (gray opossum) ENSMMUP00000010668 Macaca mulatta (rhesus monkey) ENSMUSP00000001042 Mus musculus (house mouse) 123730 Nematostella vectensis (starlet anemone) XP_001607450.1 Nasonia vitripennis (wasp) ENSOANP00000018820 Ornithorynchus anatinus (platypus) ENSORLP00000013739 Oryzias latipes (japanese killifish) PHUM004839-PA Pediculus humanus (human body louse) PP19716 Pristionchus pacificus (nematode) ENSPPYP00000000934 Pongo pygmaeus (orangutan) ENSPTRP00000002286 Pan troglodytes (chimpanzee) ENSRNOP00000045539 Rattus norvegicus (norway rat) Smp_141000 Schistosoma mansoni (trematode parasite) XP_001176545.1 Strongylocentrotus purpuratus (purple sea urchin) XP_001201253.1 Strongylocentrotus purpuratus (purple sea urchin) 52288 Trichoplax adhaerens (metazoa) XP_968185.1 Tribolium castaneum (red flour beetle) ENSTNIP00000007671 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000011665 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000031274 Xenopus tropicalis (frog) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 41529 modMine - Data generated by the modENCODE project. • FBgn0038046 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV10830 LH16668 ISCW017579 FBgn0241631 FBgn0214852 FBgn0209893 FBgn0192034 FBgn0180864 JGI_V11_304101 FBgn0079022 FBgn0164756 FBgn0145514 FBgn0124933 FBgn0109354 FBgn0094062 CPIJ006945 BGIBMGA009554 ACYPI007293 GB13665 AGAP001997 AAEL015636 AAEL006048 PB22537 PHUM361360 GLEAN_04865
Synonyms & Secondary IDs ( 2 )
Reported As
Symbol Synonym	CG5641 (FBrf0198850, Quinones-Coello, 2007, Worringer et al., 2009, Keleman et al., 2009.8.5, Herold et al., 2009)
Name Synonym	Interleukin enhancer binding factor (Takahashi et al., 2001)
Secondary FlyBase IDs
References ( 19 )
Research paper	Herold et al., 2009, Mol. Cell. Biol. 29(1): 281--301 Conservation of the protein composition and electron microscopy structure of Drosophila melanogaster and human spliceosomal complexes. [FBrf0207172] Worringer et al., 2009, BMC Molec. Biol. 10: 33 The zinc finger protein Zn72D and DEAD box helicase Belle interact and control maleless mRNA and protein levels. [FBrf0208034] Takahashi et al., 2001, Proc. Natl. Acad. Sci. USA 98(7): 3920--3925 The nucleotide changes governing cuticular hydrocarbon variation and their evolution in Drosophila melanogaster. [FBrf0135925]
Supplementary material	The modENCODE Consortium, 2010, Science 330(6012): DataS14: Gene co-expression clusters. [FBrf0213979] Mummery-Widmer et al., 2009, Nature 458(7241): Supplementary Table 2 - Genome-wide bristle screen results. [FBrf0214518] Quinones-Coello, 2007, Genetics 175(3): Supplemental Table 1. List of genes associated with protein or enhancer traps. [FBrf0200393] Giot et al., 2003, Science 302(5651): Tables S1 to S7. [FBrf0166452]
Personal communication to FlyBase	Keleman et al., 2009.8.5, RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0208510] Dickson et al., 2007.7.18, RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0200327] FlyBase Curators et al., 2004-, Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. [FBrf0174215] Ryder, 2004.4.26, Exelixis CG deletion data. Exelixis CG deletion data. [FBrf0184335] Oliver, 2001.8.16, File from B. Oliver containing information on ESTs expressed in the Drosophila testis, described in Andrews et al., 2000, Genome Res. 10(12): 2030-2043 (FBrf0132348). File from B. Oliver containing information on ESTs expressed in the Drosophila testis, described in Andrews et al., 2000, Genome Res. 10(12): 2030-2043 (FBrf0132348). [FBrf0137492]
FlyBase analysis	FlyBase Curators, 2008, Insertion identifiers and alleles based on genomic location of insertions with respect to gene annotations. Insertion identifiers and alleles based on genomic location of insertions with respect to gene annotations. [FBrf0202955] FlyBase, 1992-, FlyBase curation FlyBase curation. [FBrf0105495]
Protein sequence record	Interleukin enhancer-binding factor 2 homolog. [FBrf0198850]
Website	GOA Curators et al., 2007, Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity. Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity. [FBrf0212479]
Computer file	BDGP Project Members, 2000-, Berkeley Drosophila Genome Project. Berkeley Drosophila Genome Project. [FBrf0125078]
Curated genome annotation	Kodira, 1999.11, [Annotations performed at the Celera Jamboreee.] [Annotations performed at the Celera Jamboreee.] [FBrf0126678]