FlyBase Gene Report: Dmel\Octβ2R

General Information

Symbol

Dmel\Octβ2R

Species

D. melanogaster

Name

Octopamine β2 receptor

Annotation Symbol

CG33976

Feature Type

protein_coding_gene

FlyBase ID

FBgn0038063

Gene Model Status

Current

Stock Availability

26 publicly available

Gene Summary

Autoreceptor for octopamine (OA), which is a neurotransmitter, neurohormone, and neuromodulator in invertebrates (PubMed:15998303, PubMed:21186359). Essential for ovulation and fertilization (PubMed:25099506, PubMed:25353988). During ovulation it mediates the OA-induced relaxation of the oviduct visceral muscles, by increasing cAMP levels and activating effectors such as calmodulin-dependent kinase II (CaMKII) and cAMP-dependent protein kinase A (PKA) pathways (PubMed:25353988). Positively regulates synaptic growth; an action that is antagonized by Octbeta1R (PubMed:21186359, PubMed:22553037). (UniProt, Q4LBB9)

Contribute a Gene Snapshot for this gene.

All Summaries

Alliance
Auto summary
Gene Group
UniProtKB
Interactive Fly

Also Known As

Dm_3R:45121 , DmOctβ2R

Key Links

Genomic Location

Cytogenetic map

87C1-87C1

Sequence location

3R:12,550,625..12,595,725 [-]

Recombination map

3-52

RefSeq locus

NT_033777 REGION:12550625..12595725

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse GBrowse

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Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

GO Summary Ribbons

Gene Ontology (GO) Annotations (13 terms)

Molecular Function (4 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

enables octopamine receptor activity

inferred from direct assay

(Maqueira et al., 2005)

Terms Based on Predictions or Assertions (4 terms)

CV Term

Evidence

References

enables DNA-binding transcription factor activity

inferred from electronic annotation with InterPro:IPR004827

(assigned by InterPro )

(FlyBase Curators et al., 2004-)

enables G protein-coupled amine receptor activity

inferred from sequence or structural similarity

(Brody and Cravchik, 2000)

enables G protein-coupled receptor activity

inferred from biological aspect of ancestor with PANTHER:PTN002798190

(assigned by GO_Central )

(Gaudet et al., 2011)

enables octopamine receptor activity

inferred from biological aspect of ancestor with PANTHER:PTN001206597

(assigned by GO_Central )

(Gaudet et al., 2011)

inferred from sequence or structural similarity with UniProtKB:Q9VCZ3

(Maqueira et al., 2005)

Biological Process (7 terms)

Terms Based on Experimental Evidence (4 terms)

CV Term

Evidence

References

involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway

inferred from direct assay

(Maqueira et al., 2005)

involved_in fertilization

inferred from mutant phenotype

(Li et al., 2015)

involved_in ovulation

inferred from mutant phenotype

(Li et al., 2015)

involved_in positive regulation of synaptic assembly at neuromuscular junction

inferred from mutant phenotype

(Koon and Budnik, 2012)

Terms Based on Predictions or Assertions (4 terms)

CV Term

Evidence

References

involved_in adenylate cyclase-activating adrenergic receptor signaling pathway

inferred from biological aspect of ancestor with PANTHER:PTN001205212

(assigned by GO_Central )

(Gaudet et al., 2011)

involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway

inferred from sequence or structural similarity with UniProtKB:Q9VCZ3

(Maqueira et al., 2005)

involved_in G protein-coupled receptor signaling pathway

inferred from sequence or structural similarity

(Brody and Cravchik, 2000)

involved_in regulation of transcription, DNA-templated

inferred from electronic annotation with InterPro:IPR004827

(assigned by InterPro )

(FlyBase Curators et al., 2004-)

Cellular Component (2 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

located_in integral component of plasma membrane

inferred from direct assay

(Maqueira et al., 2005)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

located_in integral component of membrane

inferred from sequence or structural similarity

(Brody and Cravchik, 2000)

is_active_in integral component of plasma membrane

inferred from biological aspect of ancestor with PANTHER:PTN002798190

(assigned by GO_Central )

(Gaudet et al., 2011)

Gene Group (FlyBase)

OCTOPAMINE RECEPTORS

Protein Family (UniProt)

Belongs to the G-protein coupled receptor 1 family. (Q4LBB9)

Protein Signatures (InterPro)

Summaries

Gene Group (FlyBase)

OCTOPAMINE RECEPTORS -: Octopamine receptors belong to the Class A GPCR family. In mammalian systems, octopamine is a member of the trace amines, but in insects octopamine and tyramine are thought to be the main neurotransmitters. (Adapted from PMID:17088868, FBrf0214056 and FBrf0190865).

Protein Function (UniProtKB)

(UniProt, Q4LBB9)

Summary (Interactive Fly)

G-protein coupled receptor - autoregulatory control of synaptic and behavioral plasticity at excitatory synapses - control of appetitive motivation

Interactive Fly

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Octβ2R for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure New Section

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q4LBB9)

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Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Comments on Gene Model

Gene model reviewed during 5.56

Gene model reviewed during 5.44

Stop-codon suppression (UAA) postulated; FBrf0216884.

Gene model reviewed during 6.02

Low-frequency RNA-Seq exon junction(s) not annotated.

Sequence Ontology: Class of Gene

gene_with_stop_codon_read_through

(Jungreis et al., 2011)

nuclear_gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Octβ2R-RA

FBtr0100019

NM_001038960

2260

536

Octβ2R-RC

FBtr0304844

NM_001260147

3229

536

Octβ2R-RD

FBtr0304845

NM_001260148

3063

536

Octβ2R-RE

FBtr0304846

NM_001260149

6593

536

Octβ2R-RF

FBtr0330120

NM_001170125

2260

630

Octβ2R-RG

FBtr0347149

NM_001316576

6672

536

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank

Octβ2R-PA

FBpp0099980

60.4

536

8.94

NP_001034049

AAF54835

Octβ2R-PC

FBpp0293384

60.4

536

8.94

NP_001247076

AFH06394

Octβ2R-PD

FBpp0293385

60.4

536

8.94

NP_001247077

AFH06395

Octβ2R-PE

FBpp0293386

60.4

536

8.94

NP_001247078

AFH06396

Octβ2R-PF

FBpp0303153

70.3

630

8.77

NP_001163596

ACZ94893

Octβ2R-PG

FBpp0312480

60.4

536

8.94

NP_001303505

ALI30563

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

536 aa isoforms: Octβ2R-PA, Octβ2R-PC, Octβ2R-PD, Octβ2R-PE, Octβ2R-PG

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Octβ2R using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Linkouts

Expression Data

Expression Summary Ribbons

Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.

For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.

Transcript Expression

RT-PCR

Stage

Tissue/Position (including subcellular localization)

Reference

third instar larval stage

embryonic/larval brain

(El-Kholy et al., 2015)

embryonic/larval hindgut

(El-Kholy et al., 2015)

embryonic/larval tracheal section

(El-Kholy et al., 2015)

embryonic/larval fat body

(El-Kholy et al., 2015)

embryonic/larval salivary gland

(El-Kholy et al., 2015)

embryonic/larval Malpighian tubule

(El-Kholy et al., 2015)

adult stage

adult brain

(El-Kholy et al., 2015)

adult muscle system

(El-Kholy et al., 2015)

adult hindgut

(El-Kholy et al., 2015)

adult fat body

(El-Kholy et al., 2015)

adult tracheal section

(El-Kholy et al., 2015)

adult Malpighian tubule

(El-Kholy et al., 2015)

female reproductive system

(El-Kholy et al., 2015)

male reproductive system

(El-Kholy et al., 2015)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

immunolocalization

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

alpha'/beta' Kenyon cell

(Sato et al., 2010)

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in integral component of plasma membrane

inferred from direct assay

(Maqueira et al., 2005)

Expression Deduced from Reporters

Reporter: P{Octβ2R-GAL4.L}

Stage

Tissue/Position (including subcellular localization)

Reference

third instar larval stage

embryonic/larval somatic muscle cell

(El-Kholy et al., 2015)

embryonic/larval brain | restricted

(El-Kholy et al., 2015)

larval abdominal neuromere | faint | restricted

(El-Kholy et al., 2015)

High-Throughput Expression Data

Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Octβ2R in GBrowse 2

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Octβ2R

View exonic expression by tissue for Dmel\Octβ2R

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0038063

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

41549/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0038063

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0038063

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0038063

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG6989

Flygut - An atlas of the Drosophila adult midgut

FBgn0038063

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 19 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 11 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Octβ2R

Transgenic constructs containing regulatory region of Octβ2R

Aberrations (Deficiencies and Duplications) ( 1 )

Inferred from experimentation ( 1 )

Gene disrupted in

Df(3R)Exel7317

(Ryder, 2004.4.26)

Inferred from location ( 0 )

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

viable

Octβ2R^f05679

viable, with Scer\GAL4^Mef2.PR

viable, with Scer\GAL4^pnr-MD237

Sterility

Allele

female semi-fertile, with Scer\GAL4^Mef2.PU

Octβ2R^KK109808

female semi-sterile, with Scer\GAL4^Tub.PU

Octβ2R^KK109808

female sterile

Octβ2R^f05679

female sterile | recessive

Octβ2R^f05679

fertile

Octβ2R^f05679

Other Phenotypes

Allele

abnormal locomotor behavior | third instar larval stage

Octβ2R^f05679

abnormal memory | adult stage, with Scer\GAL4^GMR26E01

Octβ2R^KK109808

abnormal memory | adult stage, with Scer\GAL4^GMR42D07

Octβ2R^KK109808

abnormal memory | adult stage, with Scer\GAL4^VT037861

Octβ2R^KK109808

abnormal memory | adult stage, with Scer\GAL4^VT050658

Octβ2R^KK109808

abnormal neuroanatomy | recessive | third instar larval stage

Octβ2R^f05679

abnormal neurophysiology

Octβ2R^f05679

abnormal sleep

Octβ2R^f05679

abnormal sleep | adult stage

abnormal starvation stress response

Octβ2R^f05679

abnormal starvation stress response, with Scer\GAL4^futsch-C380

abnormal starvation stress response, with Scer\GAL4^Tdc2.PC

decreased fecundity | female | recessive

Octβ2R^f05679

Phenotype manifest in

Allele

egg

Octβ2R^f05679

egg | decreased number

Octβ2R^f05679

embryonic/larval neuromuscular junction | third instar larval stage

Octβ2R^f05679

embryonic/larval neuromuscular junction | third instar larval stage, with Scer\GAL4^futsch-C380

embryonic/larval neuromuscular junction | third instar larval stage, with Scer\GAL4^Tdc2.PC

multidendritic neuron | third instar larval stage

Octβ2R^f05679

ovary

Octβ2R^f05679

type I bouton | third instar larval stage

Octβ2R^f05679

type I bouton | third instar larval stage, with Scer\GAL4^futsch-C380

type I bouton | third instar larval stage, with Scer\GAL4^Tdc2.PC

type II bouton | third instar larval stage

Octβ2R^f05679

type II bouton | third instar larval stage, with Scer\GAL4^futsch-C380

type II bouton | third instar larval stage, with Scer\GAL4^Tdc2.PC

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v8.0)

Homo sapiens (Human) (14)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Hsap\ADRB2

5 of 15

Yes

Hsap\HTR4

5 of 15

Yes

Hsap\ADRB1

4 of 15

Yes

Hsap\ADRB3

3 of 15

Yes

Hsap\DRD1

2 of 15

Hsap\DRD5

2 of 15

Hsap\GPR148

1 of 15

Yes

Hsap\TAAR1

1 of 15

Yes

Hsap\TAAR2

1 of 15

Yes

Hsap\TAAR3P

1 of 15

Yes

Hsap\TAAR5

1 of 15

Yes

Hsap\TAAR6

1 of 15

Yes

Hsap\TAAR8

1 of 15

Yes

Hsap\TAAR9

1 of 15

Yes

Model Organism Orthologs (via DIOPT v8.0)

Mus musculus (laboratory mouse) (21)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Mmus\Adrb2

5 of 15

Yes

Mmus\Adrb1

4 of 15

Yes

Mmus\Htr4

4 of 15

Mmus\Adrb3

3 of 15

Yes

Mmus\Drd1

2 of 15

Mmus\Drd5

2 of 15

Mmus\Taar1

1 of 15

Yes

Mmus\Taar2

1 of 15

Yes

Mmus\Taar3

1 of 15

Yes

Mmus\Taar4

1 of 15

Yes

Mmus\Taar5

1 of 15

Yes

Mmus\Taar6

1 of 15

Yes

Mmus\Taar7a

1 of 15

Yes

Mmus\Taar7b

1 of 15

Yes

Mmus\Taar7d

1 of 15

Yes

Mmus\Taar7e

1 of 15

Yes

Mmus\Taar7f

1 of 15

Yes

Mmus\Taar8a

1 of 15

Yes

Mmus\Taar8b

1 of 15

Yes

Mmus\Taar8c

1 of 15

Yes

Mmus\Taar9

1 of 15

Yes

Rattus norvegicus (Norway rat) (22)

Rnor\Htr4

5 of 13

Yes

Rnor\Adrb1

4 of 13

Yes

Rnor\Adrb2

4 of 13

Yes

Rnor\Adrb3

3 of 13

Yes

Rnor\Drd5

2 of 13

Rnor\Taar7h

2 of 13

Yes

Rnor\Drd1

1 of 13

Rnor\LOC100910174

1 of 13

Yes

Rnor\Taar1

1 of 13

Yes

Rnor\Taar2

1 of 13

Yes

Rnor\Taar3

1 of 13

Yes

Rnor\Taar4

1 of 13

Yes

Rnor\Taar5

1 of 13

Yes

Rnor\Taar6

1 of 13

Yes

Rnor\Taar7a

1 of 13

Yes

Rnor\Taar7b

1 of 13

Yes

Rnor\Taar7d

1 of 13

Yes

Rnor\Taar7e

1 of 13

Yes

Rnor\Taar7g

1 of 13

Yes

Rnor\Taar8b

1 of 13

Yes

Rnor\Taar8c

1 of 13

Yes

Rnor\Taar9

1 of 13

Yes

Xenopus tropicalis (Western clawed frog) (7)

Xtro\htr4

3 of 12

Yes

Xtro\adrb1

2 of 12

Yes

Xtro\adrb2

2 of 12

Yes

2 of 12

2 of 12

2 of 12

2 of 12

Yes

Danio rerio (Zebrafish) (94)

Drer\adrb3b

4 of 15

Yes

Drer\adrb1

3 of 15

Yes

Drer\adrb2a

3 of 15

Yes

Drer\adrb2b

3 of 15

Yes

Drer\adrb3a

3 of 15

Yes

Drer\si:dkey-247m21.3

3 of 15

Yes

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

Yes

Drer\LOC563567

2 of 15

Drer\LOC567498

2 of 15

Drer\taar12a

2 of 15

Yes

Drer\taar12b

2 of 15

Yes

Drer\taar12c

2 of 15

Yes

Drer\taar12e

2 of 15

Yes

Drer\taar12f

2 of 15

Yes

Drer\taar12g

2 of 15

Yes

Drer\taar12h

2 of 15

Yes

Drer\taar12i

2 of 15

Yes

Drer\taar12j

2 of 15

Yes

Drer\taar12m

2 of 15

Yes

Drer\taar19t

2 of 15

Yes

Drer\hrh2b

1 of 15

Drer\LOC100149223

1 of 15

Yes

Drer\si:ch211-238p8.18

1 of 15

Yes

Drer\si:ch211-238p8.24

1 of 15

Yes

Drer\si:dkey-181m19.17

1 of 15

Yes

Drer\si:dkey-246e3.4

1 of 15

Yes

Drer\taar1b

1 of 15

Yes

Drer\taar10a

1 of 15

Yes

Drer\taar10b

1 of 15

Yes

Drer\taar10c

1 of 15

Yes

Drer\taar10d

1 of 15

Yes

Drer\taar10

1 of 15

Yes

Drer\taar11

1 of 15

Yes

Drer\taar13a

1 of 15

Yes

Drer\taar13b

1 of 15

Yes

Drer\taar13c

1 of 15

Yes

Drer\taar13d

1 of 15

Yes

Drer\taar13e

1 of 15

Yes

Drer\taar14a

1 of 15

Yes

Drer\taar14b

1 of 15

Yes

Drer\taar14d

1 of 15

Yes

Drer\taar14e

1 of 15

Yes

Drer\taar14f

1 of 15

Yes

Drer\taar14g

1 of 15

Yes

Drer\taar14h

1 of 15

Yes

Drer\taar14i

1 of 15

Yes

Drer\taar14j

1 of 15

Yes

Drer\taar14l

1 of 15

Yes

Drer\taar16f

1 of 15

Yes

Drer\taar16g

1 of 15

Yes

Drer\taar17a

1 of 15

Yes

Drer\taar18a

1 of 15

Yes

Drer\taar18b

1 of 15

Yes

Drer\taar18c

1 of 15

Yes

Drer\taar18d

1 of 15

Yes

Drer\taar18g

1 of 15

Yes

Drer\taar18h

1 of 15

Yes

Drer\taar18i

1 of 15

Yes

Drer\taar18j

1 of 15

Yes

Drer\taar19a

1 of 15

Yes

Drer\taar19b

1 of 15

Yes

Drer\taar19c

1 of 15

Yes

Drer\taar19d

1 of 15

Yes

Drer\taar19g

1 of 15

Yes

Drer\taar19j

1 of 15

Yes

Drer\taar19k

1 of 15

Yes

Drer\taar19o

1 of 15

Yes

Drer\taar19r

1 of 15

Yes

Drer\taar19s

1 of 15

Yes

Drer\taar20a1

1 of 15

Yes

Drer\taar20a

1 of 15

Yes

Drer\taar20b1

1 of 15

Yes

Drer\taar20b

1 of 15

Yes

Drer\taar20c1

1 of 15

Yes

Drer\taar20c

1 of 15

Yes

Drer\taar20d1

1 of 15

Yes

Drer\taar20h

1 of 15

Yes

Drer\taar20i

1 of 15

Yes

Drer\taar20j

1 of 15

Yes

Drer\taar20l

1 of 15

Yes

Drer\taar20n

1 of 15

Yes

Drer\taar20o

1 of 15

Yes

Drer\taar20r

1 of 15

Yes

Drer\taar20t

1 of 15

Yes

Drer\taar20u

1 of 15

Yes

Drer\taar20v

1 of 15

Yes

Drer\taar20w

1 of 15

Yes

Drer\taar20x

1 of 15

Yes

Drer\taar20z

1 of 15

Yes

Drer\zgc:162592

1 of 15

Caenorhabditis elegans (Nematode, roundworm) (4)

Cele\ckr-2

1 of 15

Yes

Cele\dop-1

1 of 15

Yes

Cele\F59D12.1

1 of 15

Yes

Cele\ser-5

1 of 15

Yes

Arabidopsis thaliana (thale-cress) (0)

No records found.

Saccharomyces cerevisiae (Brewer's yeast) (0)

No records found.

Schizosaccharomyces pombe (Fission yeast) (0)

No records found.

Other Organism Orthologs (via OrthoDB)

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v8.0)

Drosophila melanogaster (Fruit fly) (11)

Gene Symbol

Score

Source

Alignment

4 of 10

2 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Model Summary Ribbon

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 3 )

Human Ortholog

Disease

Evidence

References

ADRB2; adrenoceptor beta 2

model of asthma

IEA

(FlyBase, 2019-)

model of obesity

IEA

(FlyBase, 2019-)

ADRB3; adrenoceptor beta 3

model of obesity

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

ADRB2; adrenoceptor beta 2

5 of 15

109690

HTR4; 5-hydroxytryptamine receptor 4

5 of 15

602164

ADRB1; adrenoceptor beta 1

4 of 15

109630

ADRB3; adrenoceptor beta 3

3 of 15

109691

OBESITY

obesity

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Interactions Browser

Summary of Genetic Interactions

esyN Network Diagram

esyN Network Key:

Suppression

Enhancement

View in Interactions Browser

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

suppressible

(Lim et al., 2014)

suppressible

(Lim et al., 2014)

suppressible

(Lim et al., 2014, Koon and Budnik, 2012)

suppressible

(Lim et al., 2014)

suppressible

(Lim et al., 2014)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Octβ1R

suppressible

Octβ2R

(Koon and Budnik, 2012)

rad

enhanceable

Octβ2R

(Yang et al., 2016)

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

66644

DroID - A comprehensive database of gene and protein interactions.

FBgn0038063

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0038063

External Data

Linkouts

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

3-52

Cytogenetic map

87C1-87C1

Sequence location

3R:12,550,625..12,595,725 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

87C1-87C1

Limits computationally determined from genome sequence between P{PZ}svp⁰⁷⁸⁴² and P{lacW}Vha55^j2E9

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

3-52

(FlyBase, 2016)

3-49.7

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (26)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

78806

P{UAS-Octβ2R.S}1, w^*

82785

y¹; M{WKO.1-H1}ZH-86Fb

78808

w^*; P{UAS-Octβ2R.S}3/MKRS

86135

w^*; P{UAS-Octβ2R.D}attP40

78805

w^*; Octβ2R^Δ3.22/MKRS

86142

TI{2A-GAL4}Octβ2R^2A-B.GAL4.KI

18896

w¹¹¹⁸; PBac{WH}Octβ2R^f05679

86285

TI{2A-lexA::GAD}Octβ2R^{2A-ACDE.lexA.KI}

50580

y¹ v¹; P{TRiP.GLC01702}attP40

VDRC

v104050

P{KK112557}VIE-260B

v104524

P{KK109808}VIE-260B

v8486

w¹¹¹⁸; P{GD2954}v8486

More stocks available...

Genomic Clones (39)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (2)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

IP21062

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0038063

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

194796

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0038063

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

41549

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Wu et al., 2013)

Commercially Available Antibodies

Other Information

Relationship to Other Genes

Source for database identify of

Source for identity of: Octβ2R CG6989 CG18553

(Evans, 2005.2.16)

Source for identity of: Octβ2R CG33976

(FlyBase Genome Annotators, 2005)

Source for database merge of

Source for merge of: CG6989 CG18553

(Evans, 2005.2.16, FlyBase Genome Annotators, 2005)

Source for merge of: CG6989 anon-WO0170980.184 anon-WO0170980.185

(FlyBase, 1996-)

Additional comments

Source for merge of CG6989 anon-WO0170980.184 anon-WO0170980.185 was sequence comparison ( date:051113 ).

(FlyBase Genome Annotators, 2005, FlyBase, 1996-)

Other Comments

Origin and Etymology

Discoverer

Etymology

Identification

External Crossreferences and Linkouts ( 59 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

41549

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q4LBB9

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

Q4LBB9

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q4LBB9

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0038063

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0038063

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

41549/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0038063

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0038063

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0038063

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG6989

Flygut - An atlas of the Drosophila adult midgut

FBgn0038063

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0038063

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

41549

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

Dmel_CG33976

MARRVEL_MODEL - MARRVEL (model organism gene)

41549

modMine - A data warehouse for the modENCODE project

FBgn0038063

Linkouts

BioGRID - A database of protein and genetic interactions.

66644

DroID - A comprehensive database of gene and protein interactions.

FBgn0038063

DRSC - Results frm RNAi screens

FBgn0038063

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0038063

FlyMine - An integrated database for Drosophila genomics

FBgn0038063

Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution

Interactive Fly

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Synonyms and Secondary IDs (22)

Reported As

Symbol Synonym

CG18553

CG33976

(Ward and Moehring, 2021, Kondo et al., 2020, Koon et al., 2011, Ni et al., 2010.12.1, Keleman et al., 2009.8.5, FlyBase Genome Annotators, 2005)

CG6989

(Hauser et al., 2006, Evans and Maqueira, 2005, Maqueira et al., 2005, Metpally and Sowdhamini, 2005, Bryson-Richardson et al., 2004, Lai et al., 2003, Brody and Cravchik, 2000)

DmCG6989

(Roeder et al., 2003)

DmOctβ2R

(Qi et al., 2017, Maqueira et al., 2005)

Dm_3R:45121

(FlyBase Genome Annotators, 2014, Ladoukakis et al., 2011)

OCTβ2R

(Perry and Barron, 2013)

OctB2R

(Crocker et al., 2010)

OctBeta2

(Evans, 2005.2.16)

Octbeta2R

(Deng, 2020.1.10, Kondo et al., 2020, Rao and Deng, 2019.10.23, Ugrankar et al., 2018, Clandinin and Owens, 2016-, Crocker et al., 2016, Gene Disruption Project members, 2016-, Ashwal-Fluss et al., 2014, Chen et al., 2014, Izutsu et al., 2012, Jungreis et al., 2011, Brody, 2009.3.30)

Octβ-like

(Roeder et al., 2009)