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Gene: Dmel\Octβ2R

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General Information
Symbol
Dmel\Octβ2R
Species
D. melanogaster
Name
Octopamine β2 receptor
Annotation Symbol
CG33976
Feature Type
protein_coding_gene
FlyBase ID
FBgn0038063
Gene Model Status
Current
Stock Availability
16 publicly available
Gene Snapshot
In progress.Contributions welcome.
Other Summaries
Also Known As
octβ2R, DmOctβ2R, Dm_3R:45121
Key Links
Genomic Location
Cytogenetic map
87C1-87C2
Sequence location
3R:12,550,625..12,595,725 [-]
Recombination map
3-52
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI Genome Data Viewer
UCSC Genome Browser
Ensembl Genome Browser
PopFly Genome Browser
GO Summary Ribbons
Families, Domains and Molecular Function
Gene Group Membership (FlyBase)
Protein Family (UniProt, Sequence Similarities)
Belongs to the G-protein coupled receptor 1 family. (Q4LBB9)
Protein Domains/Motifs
InterPro
G protein-coupled receptor, rhodopsin-like; Basic-leucine zipper domain; GPCR, rhodopsin-like, 7TM
Molecular Function (see GO section for details)
Experimental Evidence
octopamine receptor activity
Predictions / Assertions
DNA-binding transcription factor activity; G-protein coupled amine receptor activity; octopamine receptor activity
Summaries
Gene Group Membership
OCTOPAMINE RECEPTORS -
Octopamine receptors belong to the Class A GPCR family. In mammalian systems, octopamine is a member of the trace amines, but in insects octopamine and tyramine are thought to be the main neurotransmitters. (Adapted from PMID:17088868, FBrf0214056 and FBrf0190865).
UniProt Contributed Function Data
Autoreceptor for octopamine (OA), which is a neurotransmitter, neurohormone, and neuromodulator in invertebrates (PubMed:15998303, PubMed:21186359). Essential for ovulation and fertilization (PubMed:25099506, PubMed:25353988). During ovulation it mediates the OA-induced relaxation of the oviduct visceral muscles, by increasing cAMP levels and activating effectors such as calmodulin-dependent kinase II (CaMKII) and cAMP-dependent protein kinase A (PKA) pathways (PubMed:25353988). Positively regulates synaptic growth; an action that is antagonized by Octbeta1R (PubMed:21186359, PubMed:22553037).
(UniProt, Q4LBB9)
Gene Model and Products
Number of Transcripts
6
Number of Unique Polypeptides
2

Please see the GBrowse view of Dmel\Octβ2R or the JBrowse view of Dmel\Octβ2R for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model
Gene model reviewed during 5.56
Gene model reviewed during 5.44
Stop-codon suppression (UAA) postulated; FBrf0216884.
gene_with_stop_codon_read_through ; SO:0000697
Gene model reviewed during 6.02
Low-frequency RNA-Seq exon junction(s) not annotated.
Sequence Ontology: Class of Gene
gene_with_stop_codon_read_through
(Jungreis et al., 2011)
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Octβ2R-RA
FBtr0100019
NM_001038960
2260
536
Octβ2R-RC
FBtr0304844
NM_001260147
3229
536
Octβ2R-RD
FBtr0304845
NM_001260148
3063
536
Octβ2R-RE
FBtr0304846
NM_001260149
6593
536
Octβ2R-RF
FBtr0330120
NM_001170125
2260
630
Octβ2R-RG
FBtr0347149
NM_001316576
6672
536
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
Octβ2R-PA
FBpp0099980
60.4
536
8.94
NP_001034049
AAF54835
Octβ2R-PC
FBpp0293384
60.4
536
8.94
NP_001247076
AFH06394
Octβ2R-PD
FBpp0293385
60.4
536
8.94
NP_001247077
AFH06395
Octβ2R-PE
FBpp0293386
60.4
536
8.94
NP_001247078
AFH06396
Octβ2R-PF
FBpp0303153
70.3
630
8.77
NP_001163596
ACZ94893
Octβ2R-PG
FBpp0312480
60.4
536
8.94
NP_001303505
ALI30563
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

536 aa isoforms: Octβ2R-PA, Octβ2R-PC, Octβ2R-PD, Octβ2R-PE, Octβ2R-PG
Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Octβ2R using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Gene Ontology (11 terms)
Molecular Function (3 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
octopamine receptor activity
inferred from direct assay
(Maqueira et al., 2005)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
DNA-binding transcription factor activity
inferred from electronic annotation with InterPro:IPR004827
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
G-protein coupled amine receptor activity
inferred from sequence or structural similarity
(Brody and Cravchik, 2000)
octopamine receptor activity
inferred from sequence or structural similarity with UniProtKB:Q9VCZ3
(Maqueira et al., 2005)
inferred from biological aspect of ancestor with PANTHER:PTN001206597
(assigned by GO_Central )
(Gaudet et al., 2011)
Biological Process (6 terms)
Terms Based on Experimental Evidence (4 terms)
CV Term
Evidence
References
adenylate cyclase-activating G-protein coupled receptor signaling pathway
inferred from direct assay
(Maqueira et al., 2005)
fertilization
inferred from mutant phenotype
(Li et al., 2015)
ovulation
inferred from mutant phenotype
(Li et al., 2015)
positive regulation of synaptic growth at neuromuscular junction
inferred from mutant phenotype
(Koon and Budnik, 2012)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
adenylate cyclase-activating G-protein coupled receptor signaling pathway
inferred from sequence or structural similarity with UniProtKB:Q9VCZ3
(Maqueira et al., 2005)
G-protein coupled receptor signaling pathway
inferred from sequence or structural similarity
(Brody and Cravchik, 2000)
regulation of transcription, DNA-templated
inferred from electronic annotation with InterPro:IPR004827
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
Cellular Component (2 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
integral component of plasma membrane
inferred from direct assay
(Maqueira et al., 2005)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
integral component of membrane
inferred from sequence or structural similarity
(Brody and Cravchik, 2000)
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
integral component of plasma membrane
inferred from direct assay
(Maqueira et al., 2005)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Octβ2R in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs and Phenotypes
Classical and Insertion Alleles ( 7 )
Transgenic Constructs ( 7 )
Deletions and Duplications ( 1 )
Summary of Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
viable
viable, with Scer\GAL4Mef2.PR
viable, with Scer\GAL4pnr-MD237
Sterility
Allele
female semi-fertile, with Scer\GAL4Mef2.PU
female semi-sterile, with Scer\GAL4Tub.PU
female sterile
fertile
Other Phenotypes
Allele
locomotor behavior defective | third instar larval stage
neuroanatomy defective | recessive | third instar larval stage
neurophysiology defective
sleep defective
starvation stress response defective
starvation stress response defective, with Scer\GAL4futsch-C380
starvation stress response defective, with Scer\GAL4Tdc2.PC
Phenotype manifest in
Allele
egg
embryonic/larval neuromuscular junction | third instar larval stage
embryonic/larval neuromuscular junction | third instar larval stage, with Scer\GAL4futsch-C380
embryonic/larval neuromuscular junction | third instar larval stage, with Scer\GAL4Tdc2.PC
multidendritic neuron | third instar larval stage
ovary
type I bouton | third instar larval stage
type I bouton | third instar larval stage, with Scer\GAL4futsch-C380
type I bouton | third instar larval stage, with Scer\GAL4Tdc2.PC
type II bouton | third instar larval stage
type II bouton | third instar larval stage, with Scer\GAL4futsch-C380
type II bouton | third instar larval stage, with Scer\GAL4Tdc2.PC
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v7.1)
Homo sapiens (Human) (12)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\ADRB2
3 of 15
Yes
Yes
 
Hsap\HTR4
3 of 15
Yes
No
Hsap\ADRB1
1 of 15
No
No
Hsap\ADRB3
1 of 15
No
No
Hsap\DRD1
1 of 15
No
No
Hsap\DRD5
1 of 15
No
No
Hsap\TAAR1
1 of 15
No
Yes
Hsap\TAAR2
1 of 15
No
Yes
Hsap\TAAR5
1 of 15
No
Yes
Hsap\TAAR6
1 of 15
No
Yes
Hsap\TAAR8
1 of 15
No
Yes
Hsap\TAAR9
1 of 15
No
Yes
Model Organism Orthologs (via DIOPT v7.1)
Mus musculus (laboratory mouse) (21)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Adrb2
3 of 15
Yes
Yes
Mmus\Htr4
3 of 15
Yes
No
Mmus\Adrb1
1 of 15
No
No
Mmus\Adrb3
1 of 15
No
No
Mmus\Drd1
1 of 15
No
No
Mmus\Drd5
1 of 15
No
No
Mmus\Taar1
1 of 15
No
Yes
Mmus\Taar2
1 of 15
No
Yes
Mmus\Taar3
1 of 15
No
Yes
Mmus\Taar4
1 of 15
No
Yes
Mmus\Taar5
1 of 15
No
Yes
Mmus\Taar6
1 of 15
No
Yes
Mmus\Taar7a
1 of 15
No
Yes
Mmus\Taar7b
1 of 15
No
Yes
Mmus\Taar7d
1 of 15
No
Yes
Mmus\Taar7e
1 of 15
No
Yes
Mmus\Taar7f
1 of 15
No
Yes
Mmus\Taar8a
1 of 15
No
Yes
Mmus\Taar8b
1 of 15
No
Yes
Mmus\Taar8c
1 of 15
No
Yes
Mmus\Taar9
1 of 15
No
Yes
Rattus norvegicus (Norway rat) (21)
Rnor\Htr4
3 of 13
Yes
No
Rnor\Adrb2
2 of 13
No
No
Rnor\Adrb1
1 of 13
No
No
Rnor\Adrb3
1 of 13
No
No
Rnor\Drd1
1 of 13
No
No
Rnor\Drd5
1 of 13
No
No
Rnor\Taar1
1 of 13
No
Yes
Rnor\Taar2
1 of 13
No
Yes
Rnor\Taar3
1 of 13
No
Yes
Rnor\Taar4
1 of 13
No
Yes
Rnor\Taar5
1 of 13
No
Yes
Rnor\Taar6
1 of 13
No
Yes
Rnor\Taar7a
1 of 13
No
Yes
Rnor\Taar7b
1 of 13
No
Yes
Rnor\Taar7d
1 of 13
No
Yes
Rnor\Taar7e
1 of 13
No
Yes
Rnor\Taar7g
1 of 13
No
Yes
Rnor\Taar7h
1 of 13
No
Yes
Rnor\Taar8b
1 of 13
No
Yes
Rnor\Taar8c
1 of 13
No
Yes
Rnor\Taar9
1 of 13
No
Yes
Xenopus tropicalis (Western clawed frog) (5)
Xtro\adrb2
1 of 12
Yes
Yes
Xtro\drd1c
1 of 12
Yes
No
Xtro\drd1
1 of 12
Yes
No
Xtro\drd5
1 of 12
Yes
No
Xtro\htr4
1 of 12
Yes
No
Danio rerio (Zebrafish) (73)
Drer\si:dkey-247m21.3
2 of 15
Yes
No
Drer\adrb1
1 of 15
No
No
Drer\adrb2a
1 of 15
No
No
Drer\adrb2b
1 of 15
No
No
Drer\adrb3b
1 of 15
No
No
Drer\drd1a
1 of 15
No
No
Drer\drd1b
1 of 15
No
No
Drer\drd6b
1 of 15
No
No
Drer\drd7
1 of 15
No
No
Drer\htr4
1 of 15
No
No
Drer\LOC563567
1 of 15
No
No
Drer\LOC567498
1 of 15
No
No
Drer\LOC100149223
1 of 15
No
Yes
Drer\si:dkey-246e3.4
1 of 15
No
Yes
Drer\taar1b
1 of 15
No
Yes
Drer\taar10a
1 of 15
No
Yes
Drer\taar10b
1 of 15
No
Yes
Drer\taar10c
1 of 15
No
Yes
Drer\taar10d
1 of 15
No
Yes
Drer\taar10
1 of 15
No
Yes
Drer\taar11
1 of 15
No
Yes
Drer\taar12a
1 of 15
No
Yes
Drer\taar12b
1 of 15
No
Yes
Drer\taar12c
1 of 15
No
Yes
Drer\taar12e
1 of 15
No
Yes
Drer\taar12f
1 of 15
No
Yes
Drer\taar12g
1 of 15
No
Yes
Drer\taar12h
1 of 15
No
Yes
Drer\taar12i
1 of 15
No
Yes
Drer\taar12j
1 of 15
No
Yes
Drer\taar12m
1 of 15
No
Yes
Drer\taar13b
1 of 15
No
Yes
Drer\taar13c
1 of 15
No
Yes
Drer\taar13d
1 of 15
No
Yes
Drer\taar13e
1 of 15
No
Yes
Drer\taar14a
1 of 15
No
Yes
Drer\taar14b
1 of 15
No
Yes
Drer\taar14d
1 of 15
No
Yes
Drer\taar14e
1 of 15
No
Yes
Drer\taar14f
1 of 15
No
Yes
Drer\taar14g
1 of 15
No
Yes
Drer\taar14h
1 of 15
No
Yes
Drer\taar14i
1 of 15
No
Yes
Drer\taar14j
1 of 15
No
Yes
Drer\taar14l
1 of 15
No
Yes
Drer\taar16f
1 of 15
No
Yes
Drer\taar18a
1 of 15
No
Yes
Drer\taar18b
1 of 15
No
Yes
Drer\taar18c
1 of 15
No
Yes
Drer\taar18g
1 of 15
No
Yes
Drer\taar19b
1 of 15
No
Yes
Drer\taar19c
1 of 15
No
Yes
Drer\taar19d
1 of 15
No
Yes
Drer\taar19g
1 of 15
No
Yes
Drer\taar19k
1 of 15
No
Yes
Drer\taar19o
1 of 15
No
Yes
Drer\taar19r
1 of 15
No
Yes
Drer\taar20a
1 of 15
No
Yes
Drer\taar20b
1 of 15
No
Yes
Drer\taar20c1
1 of 15
No
Yes
Drer\taar20c
1 of 15
No
Yes
Drer\taar20h
1 of 15
No
Yes
Drer\taar20i
1 of 15
No
Yes
Drer\taar20j
1 of 15
No
Yes
Drer\taar20l
1 of 15
No
Yes
Drer\taar20n
1 of 15
No
Yes
Drer\taar20o
1 of 15
No
Yes
Drer\taar20r
1 of 15
No
Yes
Drer\taar20t
1 of 15
No
Yes
Drer\taar20u
1 of 15
No
Yes
Drer\taar20w
1 of 15
No
Yes
Drer\taar20x
1 of 15
No
Yes
Drer\taar64
1 of 15
No
Yes
Caenorhabditis elegans (Nematode, roundworm) (3)
Cele\ckr-2
1 of 15
Yes
No
Cele\dop-1
1 of 15
Yes
No
Cele\F59D12.1
1 of 15
Yes
No
Arabidopsis thaliana (thale-cress) (0)
No orthologs reported.
Saccharomyces cerevisiae (Brewer's yeast) (0)
No orthologs reported.
Schizosaccharomyces pombe (Fission yeast) (0)
No orthologs reported.
Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG091908MD )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila melanogaster
fruit fly
Dmel\Octβ2R
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00011627
Drosophila simulans
Dsim\GD20557
Drosophila sechellia
Dsec\GM25999
Drosophila erecta
Dere\GG17113
Drosophila yakuba
Dyak\GE24503
Drosophila ananassae
Dana\GF23002
Drosophila pseudoobscura pseudoobscura
Dpse\GA26828
Drosophila persimilis
Dper\GL13571
Drosophila willistoni
Dwil\GK13569
Drosophila virilis
Dvir\GJ10601
Drosophila mojavensis
Dmoj\GI23111
Drosophila grimshawi
Dgri\GH18896
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091504XH )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17011642
Musca domestica
House fly
Mdoa\17024764
Glossina morsitans
Tsetse fly
Gmor\GMOY002031
Glossina morsitans
Tsetse fly
Gmor\GMOY005183
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_11895
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_11888
Mayetiola destructor
Hessian fly
Mdes\Mdes003046
Mayetiola destructor
Hessian fly
Mdes\Mdes001620
Mayetiola destructor
Hessian fly
Mdes\Mdes015187
Aedes aegypti
Yellow fever mosquito
Aaeg\GPRDOP4
Aedes aegypti
Yellow fever mosquito
Aaeg\GPRNNA2
Anopheles darlingi
American malaria mosquito
Adar\ADAC005264
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ014487
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W0B2C )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BmOAR2.1
Bombyx mori
Silkmoth
Bmor\BGIBMGA002248
Bombyx mori
Silkmoth
Bmor\BGIBMGA002249
Bombyx mori
Silkmoth
Bmor\BGIBMGA002326
Danaus plexippus
Monarch butterfly
Dple\DPOGS205366-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS200581-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS209108-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL002743
Heliconius melpomene
Postman butterfly
Hmel\HMEL014462
Heliconius melpomene
Postman butterfly
Hmel\HMEL009712
Apis florea
Little honeybee
Aflo\5278539204
Apis florea
Little honeybee
Aflo\3651180356
Apis florea
Little honeybee
Aflo\4501543908
Apis mellifera
Western honey bee
Amel\GB52879
Apis mellifera
Western honey bee
Amel\oa2
Apis mellifera
Western honey bee
Amel\GB52878
Apis mellifera
Western honey bee
Amel\GB49696
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP21653
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP11589
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP11590
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP11588
Bombus terrestris
Buff-tailed bumblebee
Bter\15202637
Bombus terrestris
Buff-tailed bumblebee
Bter\15207086
Bombus terrestris
Buff-tailed bumblebee
Bter\15202817
Bombus terrestris
Buff-tailed bumblebee
Bter\15207087
Linepithema humile
Argentine ant
Lhum\LH12970
Linepithema humile
Argentine ant
Lhum\LH12975
Linepithema humile
Argentine ant
Lhum\LH12976
Linepithema humile
Argentine ant
Lhum\LH20188
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:000d42
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:00234b
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:000d44
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:000d43
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG001703
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_00011
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_12979
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_12851
Tribolium castaneum
Red flour beetle
Tcas\TC012597
Tribolium castaneum
Red flour beetle
Tcas\TC012598
Tribolium castaneum
Red flour beetle
Tcas\TC012600
Pediculus humanus
Human body louse
Phum\PHUM549550
Pediculus humanus
Human body louse
Phum\PHUM027040
Pediculus humanus
Human body louse
Phum\PHUM497230
Rhodnius prolixus
Kissing bug
Rpro\RPRC011545
Rhodnius prolixus
Kissing bug
Rpro\RPRC014610
Rhodnius prolixus
Kissing bug
Rpro\RPRC005349
Cimex lectularius
Bed bug
Clec\CLEC025394
Cimex lectularius
Bed bug
Clec\CLEC025157
Cimex lectularius
Bed bug
Clec\CLEC025161
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI010025
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI004658
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI007386
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_13825
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_13827
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_10946
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X09X5 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR013184
Ixodes scapularis
Black-legged tick
Isca\ISCW008552
Stegodyphus mimosarum
African social velvet spider
Smim\KFM60041.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM60165.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur08g04980
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_347041
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( None identified )
No non-Arthropod Metazoa orthologies identified
Human Disease Model Data
FlyBase Human Disease Model Reports
    Alleles Reported to Model Human Disease (Disease Ontology)
    Download
    Models ( 0 )
    Allele
    Disease
    Evidence
    References
    Interactions ( 0 )
    Allele
    Disease
    Interaction
    References
    Comments ( 0 )
     
    Human Orthologs (via DIOPT v7.1)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    Complementation?
    Transgene?
    ADRB2; adrenoceptor beta 2
    3 of 15
    109690
     
    HTR4; 5-hydroxytryptamine receptor 4
    3 of 15
    602164
      Functional Complementation Data
      Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
      Interactions
      Summary of Physical Interactions
      esyN Network Diagram
      Interactions Browser
      Summary of Genetic Interactions
      esyN Network Diagram
      esyN Network Key:
      Suppression
      Enhancement
      View in Interactions Browser
      Please look at the allele data for full details of the genetic interactions
      Starting gene(s)
      Interaction type
      Interacting gene(s)
      Reference
      Octβ2R
      suppressible
      Octβ1R
      (Koon and Budnik, 2012)
      Starting gene(s)
      Interaction type
      Interacting gene(s)
      Reference
      Octβ1R
      suppressible
      Octβ2R
      (Koon and Budnik, 2012)
      External Data
      Linkouts
      BioGRID - A database of protein and genetic interactions.
      DroID - A comprehensive database of gene and protein interactions.
      InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
      Pathways
      Gene Group - Pathway Membership (FlyBase)
      External Data
      Linkouts
      Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
      Genomic Location and Detailed Mapping Data
      Chromosome (arm)
      3R
      Recombination map
      3-52
      Cytogenetic map
      87C1-87C2
      Sequence location
      3R:12,550,625..12,595,725 [-]
      FlyBase Computed Cytological Location
      Cytogenetic map
      Evidence for location
      87C1-87C2
      Limits computationally determined from genome sequence between P{PZ}svp07842 and P{lacW}Vha55j2E9
      Experimentally Determined Cytological Location
      Cytogenetic map
      Notes
      References
      Experimentally Determined Recombination Data
      Location
      3-52
      (FlyBase, 2016)
      3-49.7
      (Comeron et al., 2012)
      Left of (cM)
      Right of (cM)
      Notes
      Stocks and Reagents
      Stocks (16)
      Genomic Clones (39)
      cDNA Clones (2)
       

      Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

      cDNA clones, fully sequences
      BDGP DGC clones
        Other clones
        Drosophila Genomics Resource Center cDNA clones

        For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

        cDNA Clones, End Sequenced (ESTs)
        BDGP DGC clones
          Other clones
          RNAi and Array Information
          Linkouts
          DRSC - Results frm RNAi screens
          GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
          Antibody Information
          Laboratory Generated Antibodies
           
          polyclonal
          (Wu et al., 2013)
          Commercially Available Antibodies
           
          Other Information
          Relationship to Other Genes
          Source for database identify of
          Source for identity of: Octβ2R CG6989 CG18553
          (Evans, 2005.2.16)
          Source for identity of: Octβ2R CG33976
          (FlyBase Genome Annotators, 2005)
          Source for database merge of
          Source for merge of: CG6989 CG18553
          (Evans, 2005.2.16, FlyBase Genome Annotators, 2005)
          Source for merge of: CG6989 anon-WO0170980.184 anon-WO0170980.185
          (FlyBase, 1996-)
          Additional comments
          Source for merge of CG6989 anon-WO0170980.184 anon-WO0170980.185 was sequence comparison ( date:051113 ).
          (FlyBase Genome Annotators, 2005, FlyBase, 1996-)
          Other Comments
          Origin and Etymology
          Discoverer
          Etymology
          Identification
          External Crossreferences and Linkouts ( 53 )
          Crossreferences
          NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
          GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
          GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
          RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
          UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
          UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
          Other crossreferences
          BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
          InterPro - A database of protein families, domains and functional sites
          Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
          Linkouts
          BioGRID - A database of protein and genetic interactions.
          Drosophila Genomics Resource Center - Drosophila Genomics Resource Center cDNA clones
          DroID - A comprehensive database of gene and protein interactions.
          DRSC - Results frm RNAi screens
          Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
          FLIGHT - Cell culture data for RNAi and other high-throughput technologies
          FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
          Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
          Flygut - An atlas of the Drosophila adult midgut
          FlyMine - An integrated database for Drosophila genomics
          GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
          Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
          InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
          KEGG Genes - Molecular building blocks of life in the genomic space.
          modMine - A data warehouse for the modENCODE project
          Synonyms and Secondary IDs (19)
          Datasets (0)
          Study focus (0)
          Experimental Role
          Project
          Project Type
          Title
          References (76)