FB2021_02, released April 13, 2021

Gene: Dmel\Octβ2R

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General Information
Symbol
Dmel\Octβ2R
Species
D. melanogaster
Name
Octopamine β2 receptor
Annotation Symbol
CG33976
Feature Type
protein_coding_gene
FlyBase ID
FBgn0038063
Gene Model Status
Current
Stock Availability
26 publicly available
Gene Summary
Autoreceptor for octopamine (OA), which is a neurotransmitter, neurohormone, and neuromodulator in invertebrates (PubMed:15998303, PubMed:21186359). Essential for ovulation and fertilization (PubMed:25099506, PubMed:25353988). During ovulation it mediates the OA-induced relaxation of the oviduct visceral muscles, by increasing cAMP levels and activating effectors such as calmodulin-dependent kinase II (CaMKII) and cAMP-dependent protein kinase A (PKA) pathways (PubMed:25353988). Positively regulates synaptic growth; an action that is antagonized by Octbeta1R (PubMed:21186359, PubMed:22553037). (UniProt, Q4LBB9)
Contribute a Gene Snapshot for this gene.
All Summaries
Also Known As

DmOctβ2R, Dm_3R:45121

Key Links
Genomic Location
Cytogenetic map
87C1-87C1
Sequence location
3R:12,550,625..12,595,725 [-]
Recombination map
3-52
RefSeq locus
NT_033777 REGION:12550625..12595725
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (13 terms)
Molecular Function (4 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
enables octopamine receptor activity
inferred from direct assay
(Maqueira et al., 2005)
Terms Based on Predictions or Assertions (4 terms)
CV Term
Evidence
References
enables DNA-binding transcription factor activity
inferred from electronic annotation with InterPro:IPR004827
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
enables G protein-coupled amine receptor activity
inferred from sequence or structural similarity
(Brody and Cravchik, 2000)
enables G protein-coupled receptor activity
inferred from biological aspect of ancestor with PANTHER:PTN002798190
(assigned by GO_Central )
(Gaudet et al., 2011)
enables octopamine receptor activity
inferred from biological aspect of ancestor with PANTHER:PTN001206597
(assigned by GO_Central )
(Gaudet et al., 2011)
inferred from sequence or structural similarity with UniProtKB:Q9VCZ3
(Maqueira et al., 2005)
Biological Process (7 terms)
Terms Based on Experimental Evidence (4 terms)
CV Term
Evidence
References
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway
inferred from direct assay
(Maqueira et al., 2005)
involved_in fertilization
inferred from mutant phenotype
(Li et al., 2015)
involved_in ovulation
inferred from mutant phenotype
(Li et al., 2015)
involved_in positive regulation of synaptic growth at neuromuscular junction
inferred from mutant phenotype
(Koon and Budnik, 2012)
Terms Based on Predictions or Assertions (4 terms)
CV Term
Evidence
References
involved_in adenylate cyclase-activating adrenergic receptor signaling pathway
inferred from biological aspect of ancestor with PANTHER:PTN001205212
(assigned by GO_Central )
(Gaudet et al., 2011)
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway
inferred from sequence or structural similarity with UniProtKB:Q9VCZ3
(Maqueira et al., 2005)
involved_in G protein-coupled receptor signaling pathway
inferred from sequence or structural similarity
(Brody and Cravchik, 2000)
involved_in regulation of transcription, DNA-templated
inferred from electronic annotation with InterPro:IPR004827
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
Cellular Component (2 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
located_in integral component of plasma membrane
inferred from direct assay
(Maqueira et al., 2005)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
located_in integral component of membrane
inferred from sequence or structural similarity
(Brody and Cravchik, 2000)
located_in integral component of plasma membrane
inferred from biological aspect of ancestor with PANTHER:PTN002798190
(assigned by GO_Central )
(Gaudet et al., 2011)
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the G-protein coupled receptor 1 family. (Q4LBB9)
Protein Signatures (InterPro)
Summaries
Gene Group (FlyBase)
OCTOPAMINE RECEPTORS -
Octopamine receptors belong to the Class A GPCR family. In mammalian systems, octopamine is a member of the trace amines, but in insects octopamine and tyramine are thought to be the main neurotransmitters. (Adapted from PMID:17088868, FBrf0214056 and FBrf0190865).
Protein Function (UniProtKB)
Autoreceptor for octopamine (OA), which is a neurotransmitter, neurohormone, and neuromodulator in invertebrates (PubMed:15998303, PubMed:21186359). Essential for ovulation and fertilization (PubMed:25099506, PubMed:25353988). During ovulation it mediates the OA-induced relaxation of the oviduct visceral muscles, by increasing cAMP levels and activating effectors such as calmodulin-dependent kinase II (CaMKII) and cAMP-dependent protein kinase A (PKA) pathways (PubMed:25353988). Positively regulates synaptic growth; an action that is antagonized by Octbeta1R (PubMed:21186359, PubMed:22553037).
(UniProt, Q4LBB9)
Gene Model and Products
Number of Transcripts
6
Number of Unique Polypeptides
2

Please see the JBrowse view of Dmel\Octβ2R for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Gene model reviewed during 5.56

Gene model reviewed during 5.44

Stop-codon suppression (UAA) postulated; FBrf0216884.

Gene model reviewed during 6.02

Low-frequency RNA-Seq exon junction(s) not annotated.

Sequence Ontology: Class of Gene
gene_with_stop_codon_read_through
(Jungreis et al., 2011)
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Octβ2R-RA
FBtr0100019
NM_001038960
2260
536
Octβ2R-RC
FBtr0304844
NM_001260147
3229
536
Octβ2R-RD
FBtr0304845
NM_001260148
3063
536
Octβ2R-RE
FBtr0304846
NM_001260149
6593
536
Octβ2R-RF
FBtr0330120
NM_001170125
2260
630
Octβ2R-RG
FBtr0347149
NM_001316576
6672
536
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
Octβ2R-PA
FBpp0099980
60.4
536
8.94
NP_001034049
AAF54835
Octβ2R-PC
FBpp0293384
60.4
536
8.94
NP_001247076
AFH06394
Octβ2R-PD
FBpp0293385
60.4
536
8.94
NP_001247077
AFH06395
Octβ2R-PE
FBpp0293386
60.4
536
8.94
NP_001247078
AFH06396
Octβ2R-PF
FBpp0303153
70.3
630
8.77
NP_001163596
ACZ94893
Octβ2R-PG
FBpp0312480
60.4
536
8.94
NP_001303505
ALI30563
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

536 aa isoforms: Octβ2R-PA, Octβ2R-PC, Octβ2R-PD, Octβ2R-PE, Octβ2R-PG
Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Octβ2R using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
alpha'/beta' Kenyon cell
(Sato et al., 2010)
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in integral component of plasma membrane
inferred from direct assay
(Maqueira et al., 2005)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Octβ2R in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 19 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 11 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Octβ2R
Transgenic constructs containing regulatory region of Octβ2R
Aberrations (Deficiencies and Duplications) ( 1 )
Inferred from experimentation ( 1 )
Gene disrupted in
Df(3R)Exel7317
(Ryder, 2004.4.26)
Inferred from location ( 0 )
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
viable
viable, with Scer\GAL4Mef2.PR
viable, with Scer\GAL4pnr-MD237
Sterility
Allele
female semi-fertile, with Scer\GAL4Mef2.PU
female semi-sterile, with Scer\GAL4Tub.PU
female sterile
female sterile | recessive
fertile
Other Phenotypes
Allele
abnormal locomotor behavior | third instar larval stage
abnormal memory | adult stage, with Scer\GAL4GMR26E01
abnormal memory | adult stage, with Scer\GAL4GMR42D07
abnormal memory | adult stage, with Scer\GAL4VT037861
abnormal memory | adult stage, with Scer\GAL4VT050658
abnormal neuroanatomy | recessive | third instar larval stage
abnormal neurophysiology
abnormal sleep
abnormal sleep | adult stage
abnormal starvation stress response
abnormal starvation stress response, with Scer\GAL4futsch-C380
abnormal starvation stress response, with Scer\GAL4Tdc2.PC
decreased fecundity | female | recessive
Phenotype manifest in
Allele
egg
egg | decreased number
embryonic/larval neuromuscular junction | third instar larval stage
embryonic/larval neuromuscular junction | third instar larval stage, with Scer\GAL4futsch-C380
embryonic/larval neuromuscular junction | third instar larval stage, with Scer\GAL4Tdc2.PC
multidendritic neuron | third instar larval stage
ovary
type I bouton | third instar larval stage
type I bouton | third instar larval stage, with Scer\GAL4futsch-C380
type I bouton | third instar larval stage, with Scer\GAL4Tdc2.PC
type II bouton | third instar larval stage
type II bouton | third instar larval stage, with Scer\GAL4futsch-C380
type II bouton | third instar larval stage, with Scer\GAL4Tdc2.PC
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (14)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\ADRB2
5 of 15
Yes
Yes
1  
Hsap\HTR4
5 of 15
Yes
No
Hsap\ADRB1
4 of 15
No
Yes
Hsap\ADRB3
3 of 15
No
Yes
Hsap\DRD1
2 of 15
No
No
Hsap\DRD5
2 of 15
No
No
Hsap\GPR148
1 of 15
No
Yes
Hsap\TAAR1
1 of 15
No
Yes
Hsap\TAAR2
1 of 15
No
Yes
Hsap\TAAR3P
1 of 15
No
Yes
Hsap\TAAR5
1 of 15
No
Yes
Hsap\TAAR6
1 of 15
No
Yes
Hsap\TAAR8
1 of 15
No
Yes
Hsap\TAAR9
1 of 15
No
Yes
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (21)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Adrb2
5 of 15
Yes
Yes
Mmus\Adrb1
4 of 15
No
Yes
Mmus\Htr4
4 of 15
No
No
Mmus\Adrb3
3 of 15
No
Yes
Mmus\Drd1
2 of 15
No
No
Mmus\Drd5
2 of 15
No
No
Mmus\Taar1
1 of 15
No
Yes
Mmus\Taar2
1 of 15
No
Yes
Mmus\Taar3
1 of 15
No
Yes
Mmus\Taar4
1 of 15
No
Yes
Mmus\Taar5
1 of 15
No
Yes
Mmus\Taar6
1 of 15
No
Yes
Mmus\Taar7a
1 of 15
No
Yes
Mmus\Taar7b
1 of 15
No
Yes
Mmus\Taar7d
1 of 15
No
Yes
Mmus\Taar7e
1 of 15
No
Yes
Mmus\Taar7f
1 of 15
No
Yes
Mmus\Taar8a
1 of 15
No
Yes
Mmus\Taar8b
1 of 15
No
Yes
Mmus\Taar8c
1 of 15
No
Yes
Mmus\Taar9
1 of 15
No
Yes
Rattus norvegicus (Norway rat) (22)
Rnor\Htr4
5 of 13
Yes
No
Rnor\Adrb1
4 of 13
No
Yes
Rnor\Adrb2
4 of 13
No
Yes
Rnor\Adrb3
3 of 13
No
Yes
Rnor\Drd5
2 of 13
No
No
Rnor\Taar7h
2 of 13
No
Yes
Rnor\Drd1
1 of 13
No
No
Rnor\LOC100910174
1 of 13
No
Yes
Rnor\Taar1
1 of 13
No
Yes
Rnor\Taar2
1 of 13
No
Yes
Rnor\Taar3
1 of 13
No
Yes
Rnor\Taar4
1 of 13
No
Yes
Rnor\Taar5
1 of 13
No
Yes
Rnor\Taar6
1 of 13
No
Yes
Rnor\Taar7a
1 of 13
No
Yes
Rnor\Taar7b
1 of 13
No
Yes
Rnor\Taar7d
1 of 13
No
Yes
Rnor\Taar7e
1 of 13
No
Yes
Rnor\Taar7g
1 of 13
No
Yes
Rnor\Taar8b
1 of 13
No
Yes
Rnor\Taar8c
1 of 13
No
Yes
Rnor\Taar9
1 of 13
No
Yes
Xenopus tropicalis (Western clawed frog) (7)
Xtro\htr4
3 of 12
Yes
Yes
Xtro\adrb1
2 of 12
No
Yes
Xtro\adrb2
2 of 12
No
Yes
Xtro\drd1c
2 of 12
No
No
Xtro\drd1
2 of 12
No
No
Xtro\drd5
2 of 12
No
No
Xtro\LOC100490372
2 of 12
No
Yes
Danio rerio (Zebrafish) (94)
Drer\adrb3b
4 of 15
Yes
Yes
Drer\adrb1
3 of 15
No
Yes
Drer\adrb2a
3 of 15
No
Yes
Drer\adrb2b
3 of 15
No
Yes
Drer\adrb3a
3 of 15
No
Yes
Drer\si:dkey-247m21.3
3 of 15
No
Yes
Drer\drd1a
2 of 15
No
No
Drer\drd1b
2 of 15
No
No
Drer\drd6b
2 of 15
No
No
Drer\drd7
2 of 15
No
No
Drer\htr4
2 of 15
No
Yes
Drer\LOC563567
2 of 15
No
No
Drer\LOC567498
2 of 15
No
No
Drer\taar12a
2 of 15
No
Yes
Drer\taar12b
2 of 15
No
Yes
Drer\taar12c
2 of 15
No
Yes
Drer\taar12e
2 of 15
No
Yes
Drer\taar12f
2 of 15
No
Yes
Drer\taar12g
2 of 15
No
Yes
Drer\taar12h
2 of 15
No
Yes
Drer\taar12i
2 of 15
No
Yes
Drer\taar12j
2 of 15
No
Yes
Drer\taar12m
2 of 15
No
Yes
Drer\taar19t
2 of 15
No
Yes
Drer\hrh2b
1 of 15
No
No
Drer\LOC100149223
1 of 15
No
Yes
Drer\si:ch211-238p8.18
1 of 15
No
Yes
Drer\si:ch211-238p8.24
1 of 15
No
Yes
Drer\si:dkey-181m19.17
1 of 15
No
Yes
Drer\si:dkey-246e3.4
1 of 15
No
Yes
Drer\taar1b
1 of 15
No
Yes
Drer\taar10a
1 of 15
No
Yes
Drer\taar10b
1 of 15
No
Yes
Drer\taar10c
1 of 15
No
Yes
Drer\taar10d
1 of 15
No
Yes
Drer\taar10
1 of 15
No
Yes
Drer\taar11
1 of 15
No
Yes
Drer\taar13a
1 of 15
No
Yes
Drer\taar13b
1 of 15
No
Yes
Drer\taar13c
1 of 15
No
Yes
Drer\taar13d
1 of 15
No
Yes
Drer\taar13e
1 of 15
No
Yes
Drer\taar14a
1 of 15
No
Yes
Drer\taar14b
1 of 15
No
Yes
Drer\taar14d
1 of 15
No
Yes
Drer\taar14e
1 of 15
No
Yes
Drer\taar14f
1 of 15
No
Yes
Drer\taar14g
1 of 15
No
Yes
Drer\taar14h
1 of 15
No
Yes
Drer\taar14i
1 of 15
No
Yes
Drer\taar14j
1 of 15
No
Yes
Drer\taar14l
1 of 15
No
Yes
Drer\taar16f
1 of 15
No
Yes
Drer\taar16g
1 of 15
No
Yes
Drer\taar17a
1 of 15
No
Yes
Drer\taar18a
1 of 15
No
Yes
Drer\taar18b
1 of 15
No
Yes
Drer\taar18c
1 of 15
No
Yes
Drer\taar18d
1 of 15
No
Yes
Drer\taar18g
1 of 15
No
Yes
Drer\taar18h
1 of 15
No
Yes
Drer\taar18i
1 of 15
No
Yes
Drer\taar18j
1 of 15
No
Yes
Drer\taar19a
1 of 15
No
Yes
Drer\taar19b
1 of 15
No
Yes
Drer\taar19c
1 of 15
No
Yes
Drer\taar19d
1 of 15
No
Yes
Drer\taar19g
1 of 15
No
Yes
Drer\taar19j
1 of 15
No
Yes
Drer\taar19k
1 of 15
No
Yes
Drer\taar19o
1 of 15
No
Yes
Drer\taar19r
1 of 15
No
Yes
Drer\taar19s
1 of 15
No
Yes
Drer\taar20a1
1 of 15
No
Yes
Drer\taar20a
1 of 15
No
Yes
Drer\taar20b1
1 of 15
No
Yes
Drer\taar20b
1 of 15
No
Yes
Drer\taar20c1
1 of 15
No
Yes
Drer\taar20c
1 of 15
No
Yes
Drer\taar20d1
1 of 15
No
Yes
Drer\taar20h
1 of 15
No
Yes
Drer\taar20i
1 of 15
No
Yes
Drer\taar20j
1 of 15
No
Yes
Drer\taar20l
1 of 15
No
Yes
Drer\taar20n
1 of 15
No
Yes
Drer\taar20o
1 of 15
No
Yes
Drer\taar20r
1 of 15
No
Yes
Drer\taar20t
1 of 15
No
Yes
Drer\taar20u
1 of 15
No
Yes
Drer\taar20v
1 of 15
No
Yes
Drer\taar20w
1 of 15
No
Yes
Drer\taar20x
1 of 15
No
Yes
Drer\taar20z
1 of 15
No
Yes
Drer\zgc:162592
1 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (4)
Cele\ckr-2
1 of 15
Yes
No
Cele\dop-1
1 of 15
Yes
No
Cele\F59D12.1
1 of 15
Yes
No
Cele\ser-5
1 of 15
Yes
No
Arabidopsis thaliana (thale-cress) (0)
No records found.
Saccharomyces cerevisiae (Brewer's yeast) (0)
No records found.
Schizosaccharomyces pombe (Fission yeast) (0)
No records found.
Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG091908MD )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00011627
Drosophila simulans
Dsim\GD20557
Drosophila sechellia
Dsec\GM25999
Drosophila erecta
Dere\GG17113
Drosophila yakuba
Dyak\GE24503
Drosophila ananassae
Dana\GF23002
Drosophila pseudoobscura pseudoobscura
Dpse\GA26828
Drosophila persimilis
Dper\GL13571
Drosophila willistoni
Dwil\GK13569
Drosophila virilis
Dvir\GJ10601
Drosophila mojavensis
Dmoj\GI23111
Drosophila grimshawi
Dgri\GH18896
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091504XH )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17011642
Musca domestica
House fly
Mdoa\17024764
Glossina morsitans
Tsetse fly
Gmor\GMOY002031
Glossina morsitans
Tsetse fly
Gmor\GMOY005183
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_11895
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_11888
Mayetiola destructor
Hessian fly
Mdes\Mdes003046
Mayetiola destructor
Hessian fly
Mdes\Mdes001620
Mayetiola destructor
Hessian fly
Mdes\Mdes015187
Aedes aegypti
Yellow fever mosquito
Aaeg\GPRDOP4
Aedes aegypti
Yellow fever mosquito
Aaeg\GPRNNA2
Anopheles darlingi
American malaria mosquito
Adar\ADAC005264
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ014487
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W0B2C )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BmOAR2.1
Bombyx mori
Silkmoth
Bmor\BGIBMGA002248
Bombyx mori
Silkmoth
Bmor\BGIBMGA002249
Bombyx mori
Silkmoth
Bmor\BGIBMGA002326
Danaus plexippus
Monarch butterfly
Dple\DPOGS205366-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS200581-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS209108-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL002743
Heliconius melpomene
Postman butterfly
Hmel\HMEL014462
Heliconius melpomene
Postman butterfly
Hmel\HMEL009712
Apis florea
Little honeybee
Aflo\5278539204
Apis florea
Little honeybee
Aflo\3651180356
Apis florea
Little honeybee
Aflo\4501543908
Apis mellifera
Western honey bee
Amel\GB52879
Apis mellifera
Western honey bee
Amel\oa2
Apis mellifera
Western honey bee
Amel\GB52878
Apis mellifera
Western honey bee
Amel\GB49696
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP21653
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP11589
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP11590
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP11588
Bombus terrestris
Buff-tailed bumblebee
Bter\15202637
Bombus terrestris
Buff-tailed bumblebee
Bter\15207086
Bombus terrestris
Buff-tailed bumblebee
Bter\15202817
Bombus terrestris
Buff-tailed bumblebee
Bter\15207087
Linepithema humile
Argentine ant
Lhum\LH12970
Linepithema humile
Argentine ant
Lhum\LH12975
Linepithema humile
Argentine ant
Lhum\LH12976
Linepithema humile
Argentine ant
Lhum\LH20188
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:000d42
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:00234b
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:000d44
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:000d43
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG001703
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_00011
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_12979
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_12851
Tribolium castaneum
Red flour beetle
Tcas\TC012597
Tribolium castaneum
Red flour beetle
Tcas\TC012598
Tribolium castaneum
Red flour beetle
Tcas\TC012600
Pediculus humanus
Human body louse
Phum\PHUM549550
Pediculus humanus
Human body louse
Phum\PHUM027040
Pediculus humanus
Human body louse
Phum\PHUM497230
Rhodnius prolixus
Kissing bug
Rpro\RPRC011545
Rhodnius prolixus
Kissing bug
Rpro\RPRC014610
Rhodnius prolixus
Kissing bug
Rpro\RPRC005349
Cimex lectularius
Bed bug
Clec\CLEC025394
Cimex lectularius
Bed bug
Clec\CLEC025157
Cimex lectularius
Bed bug
Clec\CLEC025161
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI010025
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI004658
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI007386
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_13825
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_13827
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_10946
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X09X5 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR013184
Ixodes scapularis
Black-legged tick
Isca\ISCW008552
Stegodyphus mimosarum
African social velvet spider
Smim\KFM60041.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM60165.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur08g04980
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_347041
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( None identified )
No non-Arthropod Metazoa orthologies identified
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (11)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
Octβ1R
4 of 10
Octβ3R
2 of 10
CG12290
1 of 10
Dop1R1
1 of 10
Dop1R2
1 of 10
Dop2R
1 of 10
DopEcR
1 of 10
Octα2R
1 of 10
Oct-TyrR
1 of 10
TyrRII
1 of 10
TyrR
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 3 )
    Human Ortholog
    Disease
    Evidence
    References
    ADRB2; adrenoceptor beta 2
    model of  obesity
    IEA
    (FlyBase, 2019-)
    model of  asthma
    IEA
    (FlyBase, 2019-)
    ADRB3; adrenoceptor beta 3
    model of  obesity
    IEA
    (FlyBase, 2019-)
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    ADRB2; adrenoceptor beta 2
    5 of 15
    109690
     
    HTR4; 5-hydroxytryptamine receptor 4
    5 of 15
    602164
        ADRB1; adrenoceptor beta 1
        4 of 15
        109630
          ADRB3; adrenoceptor beta 3
          3 of 15
          109691
          Functional Complementation Data
          Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
          Interactions
          Summary of Physical Interactions
          esyN Network Diagram
          Interactions Browser
          Summary of Genetic Interactions
          esyN Network Diagram
          esyN Network Key:
          Suppression
          Enhancement
          View in Interactions Browser
          Please look at the allele data for full details of the genetic interactions
          Starting gene(s)
          Interaction type
          Interacting gene(s)
          Reference
          Octβ2R
          suppressible
          CaMKII
          (Lim et al., 2014)
          Octβ2R
          suppressible
          Oamb
          (Lim et al., 2014)
          Octβ2R
          suppressible
          Octβ1R
          (Lim et al., 2014, Koon and Budnik, 2012)
          Octβ2R
          suppressible
          Octβ3R
          (Lim et al., 2014)
          Octβ2R
          suppressible
          Pka-C1
          (Lim et al., 2014)
          Starting gene(s)
          Interaction type
          Interacting gene(s)
          Reference
          Octβ1R
          suppressible
          Octβ2R
          (Koon and Budnik, 2012)
          rad
          enhanceable
          Octβ2R
          (Yang et al., 2016)
          External Data
          Linkouts
          BioGRID - A database of protein and genetic interactions.
          DroID - A comprehensive database of gene and protein interactions.
          InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
          Pathways
          Signaling Pathways (FlyBase)
          Metabolic Pathways
          External Data
          Linkouts
          Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
          Genomic Location and Detailed Mapping Data
          Chromosome (arm)
          3R
          Recombination map
          3-52
          Cytogenetic map
          87C1-87C1
          Sequence location
          3R:12,550,625..12,595,725 [-]
          FlyBase Computed Cytological Location
          Cytogenetic map
          Evidence for location
          87C1-87C1
          Limits computationally determined from genome sequence between P{PZ}svp07842 and P{lacW}Vha55j2E9
          Experimentally Determined Cytological Location
          Cytogenetic map
          Notes
          References
          Experimentally Determined Recombination Data
          Location

          3-52

          (FlyBase, 2016)

          3-49.7

          (Comeron et al., 2012)
          Left of (cM)
          Right of (cM)
          Notes
          Stocks and Reagents
          Stocks (26)
          Genomic Clones (39)
          cDNA Clones (2)
           

          Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

          cDNA clones, fully sequenced
          BDGP DGC clones
            Other clones
            Drosophila Genomics Resource Center cDNA clones

            For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

            cDNA Clones, End Sequenced (ESTs)
            BDGP DGC clones
              Other clones
              RNAi and Array Information
              Linkouts
              DRSC - Results frm RNAi screens
              GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
              Antibody Information
              Laboratory Generated Antibodies
               

              polyclonal

              (Wu et al., 2013)
              Commercially Available Antibodies
               
              Other Information
              Relationship to Other Genes
              Source for database identify of

              Source for identity of: Octβ2R CG6989 CG18553

              (Evans, 2005.2.16)

              Source for identity of: Octβ2R CG33976

              (FlyBase Genome Annotators, 2005)
              Source for database merge of

              Source for merge of: CG6989 CG18553

              (Evans, 2005.2.16, FlyBase Genome Annotators, 2005)

              Source for merge of: CG6989 anon-WO0170980.184 anon-WO0170980.185

              (FlyBase, 1996-)
              Additional comments

              Source for merge of CG6989 anon-WO0170980.184 anon-WO0170980.185 was sequence comparison ( date:051113 ).

              (FlyBase Genome Annotators, 2005, FlyBase, 1996-)
              Other Comments
              Origin and Etymology
              Discoverer
              Etymology
              Identification
              External Crossreferences and Linkouts ( 53 )
              Sequence Crossreferences
              NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
              GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
              GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
              RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
              UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
              UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
              Other crossreferences
              BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
              Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
              Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
              Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
              Flygut - An atlas of the Drosophila adult midgut
              GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
              InterPro - A database of protein families, domains and functional sites
              KEGG Genes - Molecular building blocks of life in the genomic space.
              modMine - A data warehouse for the modENCODE project
              Linkouts
              BioGRID - A database of protein and genetic interactions.
              DroID - A comprehensive database of gene and protein interactions.
              DRSC - Results frm RNAi screens
              FLIGHT - Cell culture data for RNAi and other high-throughput technologies
              FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
              FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
              FlyMine - An integrated database for Drosophila genomics
              InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
              Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
              Synonyms and Secondary IDs (22)
              Reported As
              Symbol Synonym
              CG18553
              CG33976
              (Kondo et al., 2020, Koon et al., 2011, Ni et al., 2010.12.1, Keleman et al., 2009.8.5, FlyBase Genome Annotators, 2005)
              CG6989
              (Hauser et al., 2006, Evans and Maqueira, 2005, Maqueira et al., 2005, Metpally and Sowdhamini, 2005, Bryson-Richardson et al., 2004, Lai et al., 2003, Brody and Cravchik, 2000)
              DmCG6989
              (Roeder et al., 2003)
              DmOctβ2R
              (Qi et al., 2017, Maqueira et al., 2005)
              Dm_3R:45121
              (FlyBase Genome Annotators, 2014, Ladoukakis et al., 2011)
              OCTβ2R
              (Perry and Barron, 2013)
              OctB2R
              (Crocker et al., 2010)
              OctBeta2
              (Evans, 2005.2.16)
              Octbeta2R
              (Deng, 2020.1.10, Kondo et al., 2020, Rao and Deng, 2019.10.23, Ugrankar et al., 2018, Clandinin and Owens, 2016-, Crocker et al., 2016, Gene Disruption Project members, 2016-, Ashwal-Fluss et al., 2014, Chen et al., 2014, Izutsu et al., 2012, Jungreis et al., 2011, Brody, 2009.03)
              Octβ-like
              (Roeder et al., 2009)
              Octβ2R
              (Gao et al., 2020, Mazzotta et al., 2020, Deng et al., 2019, Gu et al., 2019, Kamimura et al., 2019, Meltzer et al., 2019, Meiselman et al., 2018, Tian and Wang, 2018, Youn et al., 2018, Deady and Sun, 2015, El-Kholy et al., 2015, Landayan and Wolf, 2015, Potdar and Sheeba, 2013, Koon and Budnik, 2012, Ohhara et al., 2012, Koon et al., 2011, Crocker et al., 2010)
              Octβ2r
              (Burke et al., 2012)
              anon-WO0170980.184
              anon-WO0170980.185
              octb2R
              (Shin et al., 2018)
              octβ2R
              (Li et al., 2017, Li et al., 2015)
              octβ2r
              (Lim et al., 2014)
              Name Synonyms
              Octopamine β2 receptor
              OctΒ2R
              (Meiselman et al., 2018)
              Octβ2R
              octopamine receptor
              (Selcho and Pauls, 2019)
              octopamine β receptor
              (Crocker et al., 2010)
              Secondary FlyBase IDs
              • FBgn0038064
              • FBgn0046561
              • FBgn0046562
              • FBgn0053976
              • FBtr0082672
              • FBpp0082141
              • FBtr0082673
              • FBpp0082142
              Datasets (0)
              Study focus (0)
              Experimental Role
              Project
              Project Type
              Title
              References (101)