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Gene Dmel\Octβ2R

General Information
Symbol	Dmel\Octβ2R	Species	D. melanogaster
Name	Octβ2R	Annotation symbol	CG33976
Feature type	protein_coding_gene	FlyBase ID	FBgn0038063
Gene Model Status	Current	Stock availability	7 publicly available
Also Known As	CG6989, Octbeta2R
Genomic Location
Chromosome (arm)	3R	Recombination map
Cytogenetic map	87C1-87C2	Sequence location	3R:8,378,211..8,421,447 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Octβ2R is referred to in FlyBase by the symbol Dmel\Octβ2R (CG33976, FBgn0038063). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: octopamine receptor activity. There is experimental evidence that it is involved in the biological process: positive regulation of synaptic growth at neuromuscular junction. 7 alleles are reported. No phenotypic data is available. It has 5 annotated transcripts and 5 annotated polypeptides. Protein features are: Basic-leucine zipper domain; G protein-coupled receptor, rhodopsin-like; GPCR, rhodopsin-like, 7TM. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of no expression detected. Peak expression observed during early larval stages, during late pupal stages. Summary of FlyAtlas Anatomical Expression Data: Little or no expression detected in any larval or adult organs/tissues. Gene sequence location is 3R:8378211..8421447.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 87C1-87C2   Limits computationally determined from genome sequence between P{PZ}svp07842 and P{lacW}Vha55j2E9
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Octβ2R for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene merge based on EST/cDNA data Gene model reviewed during 5.44 gene_with_stop_codon_read_through ; SO:0000697 Stop-codon suppression (UAA) postulated; FBrf0216884.
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Octβ2R-RA FBtr0100019  NM_001038960   2260   536 Octβ2R-RC FBtr0304844  NM_001260147   3229   536 Octβ2R-RD FBtr0304845  NM_001260148   3063   536 Octβ2R-RE FBtr0304846  NM_001260149   4729   536 Octβ2R-RF FBtr0330120  NM_001170125   2260   630
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Octβ2R-PA   FBpp0099980   60.4   536   8.94     NP_001034049   AAF54835 Octβ2R-PC   FBpp0293384   60.4   536   8.94     NP_001247076   AFH06394 Octβ2R-PD   FBpp0293385   60.4   536   8.94     NP_001247077   AFH06395 Octβ2R-PE   FBpp0293386   60.4   536   8.94     NP_001247078   AFH06396 Octβ2R-PF   FBpp0303153   70.3   630   8.77     NP_001163596   ACZ94893
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • G protein-coupled receptor, rhodopsin-like (IPR000276) Basic-leucine zipper domain (IPR004827) GPCR, rhodopsin-like, 7TM (IPR017452)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014297 AAF54835   AE014297 ACZ94893   AE014297 AFH06394   AE014297 AFH06395   AE014297 AFH06396   AJ880689 CAI56430   AX254617   AX254618   BI565563   BI583728   BI587299   BI609279   BT053715   CO276364   CO276724   CZ488294   CZ488295   EC060015   EC090451   EC243560
UniProtKB/Swiss-Prot	Q4LBB9
UniProtKB/TrEMBL	E1JIJ4
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Little or no expression detected in any larval or adult organs/tissues. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    0 central nervous system, larvae L3    1 central nervous system, pupae P8    1 head, virgin 1-day female    2 head, virgin 4-day female    1 head, virgin 20-day female    2 head, mated 1-day female    2 head, mated 4-day female    3 head, mated 20-day female    1 head, mated 1-day male    2 head, mated 4-day male    6 head, mated 20-day male    5 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    1 carcass, larvae L3 wandering    2 carcass, 1-day adult    2 carcass, 4-day adult    2 carcass, 20-day adult    2 ovary, virgin 4-day female    1 ovary, mated 4-day female    1 testis, mated 4-day male    1 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    0 central nervous system, larvae L3    1 central nervous system, pupae P8    1 head, virgin 1-day female    2 head, virgin 4-day female    1 head, virgin 20-day female    2 head, mated 1-day female    2 head, mated 4-day female    3 head, mated 20-day female    1 head, mated 1-day male    2 head, mated 4-day male    6 head, mated 20-day male    5 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    1 carcass, larvae L3 wandering    2 carcass, 1-day adult    2 carcass, 4-day adult    2 carcass, 20-day adult    2 ovary, virgin 4-day female    1 ovary, mated 4-day female    1 testis, mated 4-day male    1 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    0 central nervous system, larvae L3    1 central nervous system, pupae P8    1 head, virgin 1-day female    2 head, virgin 4-day female    1 head, virgin 20-day female    2 head, mated 1-day female    2 head, mated 4-day female    3 head, mated 20-day female    1 head, mated 1-day male    2 head, mated 4-day male    6 head, mated 20-day male    5 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    1 carcass, larvae L3 wandering    2 carcass, 1-day adult    2 carcass, 4-day adult    2 carcass, 20-day adult    2 ovary, virgin 4-day female    1 ovary, mated 4-day female    1 testis, mated 4-day male    1 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    0 central nervous system, larvae L3    1 central nervous system, pupae P8    1 head, virgin 1-day female    2 head, virgin 4-day female    1 head, virgin 20-day female    2 head, mated 1-day female    2 head, mated 4-day female    3 head, mated 20-day female    1 head, mated 1-day male    2 head, mated 4-day male    6 head, mated 20-day male    5 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    1 carcass, larvae L3 wandering    2 carcass, 1-day adult    2 carcass, 4-day adult    2 carcass, 20-day adult    2 ovary, virgin 4-day female    1 ovary, mated 4-day female    1 testis, mated 4-day male    1 accessory gland, mated 4-day male    0 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    0 central nervous system, larvae L3    1 central nervous system, pupae P8    1 head, virgin 1-day female    2 head, virgin 4-day female    1 head, virgin 20-day female    2 head, mated 1-day female    2 head, mated 4-day female    3 head, mated 20-day female    1 head, mated 1-day male    2 head, mated 4-day male    6 head, mated 20-day male    5 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    1 carcass, larvae L3 wandering    2 carcass, 1-day adult    2 carcass, 4-day adult    2 carcass, 20-day adult    2 ovary, virgin 4-day female    1 ovary, mated 4-day female    1 testis, mated 4-day male    1 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    0 central nervous system, larvae L3    1 central nervous system, pupae P8    1 head, virgin 1-day female    2 head, virgin 4-day female    1 head, virgin 20-day female    2 head, mated 1-day female    2 head, mated 4-day female    3 head, mated 20-day female    1 head, mated 1-day male    2 head, mated 4-day male    6 head, mated 20-day male    5 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    1 carcass, larvae L3 wandering    2 carcass, 1-day adult    2 carcass, 4-day adult    2 carcass, 20-day adult    2 ovary, virgin 4-day female    1 ovary, mated 4-day female    1 testis, mated 4-day male    1 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    0 central nervous system, larvae L3    1 central nervous system, pupae P8    1 head, virgin 1-day female    2 head, virgin 4-day female    1 head, virgin 20-day female    2 head, mated 1-day female    2 head, mated 4-day female    3 head, mated 20-day female    1 head, mated 1-day male    2 head, mated 4-day male    6 head, mated 20-day male    5 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    1 carcass, larvae L3 wandering    2 carcass, 1-day adult    2 carcass, 4-day adult    2 carcass, 20-day adult    2 ovary, virgin 4-day female    1 ovary, mated 4-day female    1 testis, mated 4-day male    1 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    0 central nervous system, larvae L3    1 central nervous system, pupae P8    1 head, virgin 1-day female    2 head, virgin 4-day female    1 head, virgin 20-day female    2 head, mated 1-day female    2 head, mated 4-day female    3 head, mated 20-day female    1 head, mated 1-day male    2 head, mated 4-day male    6 head, mated 20-day male    5 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    1 carcass, larvae L3 wandering    2 carcass, 1-day adult    2 carcass, 4-day adult    2 carcass, 20-day adult    2 ovary, virgin 4-day female    1 ovary, mated 4-day female    1 testis, mated 4-day male    1 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of no expression detected. Peak expression observed during early larval stages, during late pupal stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    1 embryo 16-18hr    1 embryo 18-20hr    4 embryo 20-22hr    6 embryo 22-24hr    6 larva L1    4 larva L2    4 larva L3 12hr old    10 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    2 larva L3 puffstage 7-9    2 white prepupae new    1 white prepupae 12hr    0 white prepupae 24hr    0 pupae 2d postWPP    0 pupae 3d postWPP    1 pupae 4d postWPP    15 adult male 01day    3 adult male 05day    3 adult male 30day    3 adult female 01day    2 adult female 05day    1 adult female 30day    1 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    1 embryo 16-18hr    1 embryo 18-20hr    4 embryo 20-22hr    6 embryo 22-24hr    6 larva L1    4 larva L2    4 larva L3 12hr old    10 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    2 larva L3 puffstage 7-9    2 white prepupae new    1 white prepupae 12hr    0 white prepupae 24hr    0 pupae 2d postWPP    0 pupae 3d postWPP    1 pupae 4d postWPP    15 adult male 01day    3 adult male 05day    3 adult male 30day    3 adult female 01day    2 adult female 05day    1 adult female 30day    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    1 embryo 16-18hr    1 embryo 18-20hr    4 embryo 20-22hr    6 embryo 22-24hr    6 larva L1    4 larva L2    4 larva L3 12hr old    10 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    2 larva L3 puffstage 7-9    2 white prepupae new    1 white prepupae 12hr    0 white prepupae 24hr    0 pupae 2d postWPP    0 pupae 3d postWPP    1 pupae 4d postWPP    15 adult male 01day    3 adult male 05day    3 adult male 30day    3 adult female 01day    2 adult female 05day    1 adult female 30day    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    1 embryo 16-18hr    1 embryo 18-20hr    4 embryo 20-22hr    6 embryo 22-24hr    6 larva L1    4 larva L2    4 larva L3 12hr old    10 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    2 larva L3 puffstage 7-9    2 white prepupae new    1 white prepupae 12hr    0 white prepupae 24hr    0 pupae 2d postWPP    0 pupae 3d postWPP    1 pupae 4d postWPP    15 adult male 01day    3 adult male 05day    3 adult male 30day    3 adult female 01day    2 adult female 05day    1 adult female 30day    1 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    1 embryo 16-18hr    1 embryo 18-20hr    4 embryo 20-22hr    6 embryo 22-24hr    6 larva L1    4 larva L2    4 larva L3 12hr old    10 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    2 larva L3 puffstage 7-9    2 white prepupae new    1 white prepupae 12hr    0 white prepupae 24hr    0 pupae 2d postWPP    0 pupae 3d postWPP    1 pupae 4d postWPP    15 adult male 01day    3 adult male 05day    3 adult male 30day    3 adult female 01day    2 adult female 05day    1 adult female 30day    1 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    1 embryo 16-18hr    1 embryo 18-20hr    4 embryo 20-22hr    6 embryo 22-24hr    6 larva L1    4 larva L2    4 larva L3 12hr old    10 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    2 larva L3 puffstage 7-9    2 white prepupae new    1 white prepupae 12hr    0 white prepupae 24hr    0 pupae 2d postWPP    0 pupae 3d postWPP    1 pupae 4d postWPP    15 adult male 01day    3 adult male 05day    3 adult male 30day    3 adult female 01day    2 adult female 05day    1 adult female 30day    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    1 embryo 16-18hr    1 embryo 18-20hr    4 embryo 20-22hr    6 embryo 22-24hr    6 larva L1    4 larva L2    4 larva L3 12hr old    10 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    2 larva L3 puffstage 7-9    2 white prepupae new    1 white prepupae 12hr    0 white prepupae 24hr    0 pupae 2d postWPP    0 pupae 3d postWPP    1 pupae 4d postWPP    15 adult male 01day    3 adult male 05day    3 adult male 30day    3 adult female 01day    2 adult female 05day    1 adult female 30day    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    1 embryo 16-18hr    1 embryo 18-20hr    4 embryo 20-22hr    6 embryo 22-24hr    6 larva L1    4 larva L2    4 larva L3 12hr old    10 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    2 larva L3 puffstage 7-9    2 white prepupae new    1 white prepupae 12hr    0 white prepupae 24hr    0 pupae 2d postWPP    0 pupae 3d postWPP    1 pupae 4d postWPP    15 adult male 01day    3 adult male 05day    3 adult male 30day    3 adult female 01day    2 adult female 05day    1 adult female 30day    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    1 Schneider line 2 Sg4    1 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    2 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    2 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    3 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    1 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    1 Schneider line 2 Sg4    1 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    2 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    2 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    3 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    1 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    1 Schneider line 2 Sg4    1 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    2 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    2 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    3 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    1 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    1 Schneider line 2 Sg4    1 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    2 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    2 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    3 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    1 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    1 Schneider line 2 Sg4    1 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    2 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    2 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    3 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    1 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    1 Schneider line 2 Sg4    1 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    2 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    2 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    3 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    1 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    1 Schneider line 2 Sg4    1 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    2 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    2 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    3 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    1 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    1 Schneider line 2 Sg4    1 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    2 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    2 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    3 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    1 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    0 cold shock, 4-day adult    0 heat shock, 4-day adult    2 Cadmium 50 mM 6 hrs, larvae L3    3 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    2 Cadmium 100 mM 48 hrs, 4-day adult    1 Copper 0.5 mM 12 hrs, larvae L3    4 Copper 15 mM 48 hrs, 4-day adult    2 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    1 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    1 Caffeine 25 mg/ml 48 hrs, 4-day adult    1 Paraquat 5 mM 48 hrs, 4-day adult    1 Paraquat 10 mM 48 hrs, 4-day adult    3 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    0 cold shock, 4-day adult    0 heat shock, 4-day adult    2 Cadmium 50 mM 6 hrs, larvae L3    3 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    2 Cadmium 100 mM 48 hrs, 4-day adult    1 Copper 0.5 mM 12 hrs, larvae L3    4 Copper 15 mM 48 hrs, 4-day adult    2 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    1 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    1 Caffeine 25 mg/ml 48 hrs, 4-day adult    1 Paraquat 5 mM 48 hrs, 4-day adult    1 Paraquat 10 mM 48 hrs, 4-day adult    3 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    0 cold shock, 4-day adult    0 heat shock, 4-day adult    2 Cadmium 50 mM 6 hrs, larvae L3    3 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    2 Cadmium 100 mM 48 hrs, 4-day adult    1 Copper 0.5 mM 12 hrs, larvae L3    4 Copper 15 mM 48 hrs, 4-day adult    2 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    1 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    1 Caffeine 25 mg/ml 48 hrs, 4-day adult    1 Paraquat 5 mM 48 hrs, 4-day adult    1 Paraquat 10 mM 48 hrs, 4-day adult    3 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    0 cold shock, 4-day adult    0 heat shock, 4-day adult    2 Cadmium 50 mM 6 hrs, larvae L3    3 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    2 Cadmium 100 mM 48 hrs, 4-day adult    1 Copper 0.5 mM 12 hrs, larvae L3    4 Copper 15 mM 48 hrs, 4-day adult    2 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    1 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    1 Caffeine 25 mg/ml 48 hrs, 4-day adult    1 Paraquat 5 mM 48 hrs, 4-day adult    1 Paraquat 10 mM 48 hrs, 4-day adult    3 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    0 cold shock, 4-day adult    0 heat shock, 4-day adult    2 Cadmium 50 mM 6 hrs, larvae L3    3 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    2 Cadmium 100 mM 48 hrs, 4-day adult    1 Copper 0.5 mM 12 hrs, larvae L3    4 Copper 15 mM 48 hrs, 4-day adult    2 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    1 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    1 Caffeine 25 mg/ml 48 hrs, 4-day adult    1 Paraquat 5 mM 48 hrs, 4-day adult    1 Paraquat 10 mM 48 hrs, 4-day adult    3 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    0 cold shock, 4-day adult    0 heat shock, 4-day adult    2 Cadmium 50 mM 6 hrs, larvae L3    3 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    2 Cadmium 100 mM 48 hrs, 4-day adult    1 Copper 0.5 mM 12 hrs, larvae L3    4 Copper 15 mM 48 hrs, 4-day adult    2 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    1 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    1 Caffeine 25 mg/ml 48 hrs, 4-day adult    1 Paraquat 5 mM 48 hrs, 4-day adult    1 Paraquat 10 mM 48 hrs, 4-day adult    3 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    0 cold shock, 4-day adult    0 heat shock, 4-day adult    2 Cadmium 50 mM 6 hrs, larvae L3    3 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    2 Cadmium 100 mM 48 hrs, 4-day adult    1 Copper 0.5 mM 12 hrs, larvae L3    4 Copper 15 mM 48 hrs, 4-day adult    2 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    1 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    1 Caffeine 25 mg/ml 48 hrs, 4-day adult    1 Paraquat 5 mM 48 hrs, 4-day adult    1 Paraquat 10 mM 48 hrs, 4-day adult    3 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    0 cold shock, 4-day adult    0 heat shock, 4-day adult    2 Cadmium 50 mM 6 hrs, larvae L3    3 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    2 Cadmium 100 mM 48 hrs, 4-day adult    1 Copper 0.5 mM 12 hrs, larvae L3    4 Copper 15 mM 48 hrs, 4-day adult    2 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    1 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    1 Caffeine 25 mg/ml 48 hrs, 4-day adult    1 Paraquat 5 mM 48 hrs, 4-day adult    1 Paraquat 10 mM 48 hrs, 4-day adult    3 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_20
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0038063 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG6989-RA;CG18553-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable Octβ2Rf05679 viable, with Scer\GAL4pnr-MD237 Octβ2RGD683 Octβ2RGD2954 Sterility Allele fertile Octβ2Rf05679 Other Phenotypes Allele locomotor behavior defective | third instar larval stage Octβ2Rf05679 neuroanatomy defective | recessive | third instar larval stage Octβ2Rf05679 neurophysiology defective Octβ2Rf05679 sleep defective Octβ2Rf05679 starvation stress response defective Octβ2Rf05679 starvation stress response defective, with Scer\GAL4futsch-C380 Octβ2RGD2954 Octβ2RKK109808 starvation stress response defective, with Scer\GAL4Tdc2.PC Octβ2RGD2954 Octβ2RKK109808 Phenotype manifest in Allele embryonic/larval neuromuscular junction | third instar larval stage Octβ2Rf05679 embryonic/larval neuromuscular junction | third instar larval stage, with Scer\GAL4futsch-C380 Octβ2RGD2954 Octβ2RKK109808 embryonic/larval neuromuscular junction | third instar larval stage, with Scer\GAL4Tdc2.PC Octβ2RGD2954 Octβ2RKK109808 multidendritic neuron | third instar larval stage Octβ2Rf05679 type I bouton | third instar larval stage Octβ2Rf05679 type I bouton | third instar larval stage, with Scer\GAL4futsch-C380 Octβ2RGD2954 Octβ2RKK109808 type I bouton | third instar larval stage, with Scer\GAL4Tdc2.PC Octβ2RGD2954 Octβ2RKK109808 type II bouton | third instar larval stage Octβ2Rf05679 type II bouton | third instar larval stage, with Scer\GAL4futsch-C380 Octβ2RGD2954 Octβ2RKK109808 type II bouton | third instar larval stage, with Scer\GAL4Tdc2.PC Octβ2RGD2954 Octβ2RKK109808
Classical Alleles ( 2 )
For All Classical Alleles Show
Allele of Octβ2R Class Mutagen Stocks Known lesion Octβ2Rf05679 piggyBac transposase 2 -- Octβ2RMI01794 1 --
Alleles Carried on Transgenic Constructs ( 5 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Octβ2R Class Mutagen Stocks Known lesion Octβ2RGD2954 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Octβ2RHMS01151 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Octβ2RKK109808 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Octβ2RKK112557 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Octβ2RGD683 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3R)Exel7317 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data
Insertions
	Type of insertions Name Expression data miscellaneous insertions Mi{MIC}Octβ2RMI01794 NA PBac{WH}Octβ2Rf05679 NA
Gene Ontology: Function, Process & Cellular Component ( 8 unique terms )
Terms Based on Experimental Evidence ( 2 terms )
Molecular Function
CV term Evidence References
octopamine receptor activity inferred from direct assay (Maqueira et al., 2005)
Biological Process
CV term Evidence References
positive regulation of synaptic growth at neuromuscular junction inferred from mutant phenotype (Koon and Budnik, 2012)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 6 terms )
Molecular Function
CV term Evidence References
G-protein coupled amine receptor activity inferred from sequence or structural similarity (Brody and Cravchik, 2000) sequence-specific DNA binding inferred from electronic annotation with InterPro:IPR004827 (FlyBase Curators et al., 2004-) sequence-specific DNA binding transcription factor activity inferred from electronic annotation with InterPro:IPR004827 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
G-protein coupled receptor signaling pathway inferred from electronic annotation with InterPro:IPR000276 (FlyBase Curators et al., 2004-) inferred from sequence or structural similarity (Brody and Cravchik, 2000) regulation of transcription, DNA-dependent inferred from electronic annotation with InterPro:IPR004827 (FlyBase Curators et al., 2004-)
Cellular Component
CV term Evidence References
integral to membrane inferred from electronic annotation with InterPro:IPR000276 (FlyBase Curators et al., 2004-) inferred from sequence or structural similarity (Brody and Cravchik, 2000)
Sequence Ontology: Class of Gene
	gene_with_stop_codon_read_through (Jungreis et al., 2011) nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Octβ2R allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 66644 DroID - A comprehensive database of gene and protein interactions. • FBgn0038063 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 41549
Orthologs
OrthoDB Orthologs (59) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6ZW5WR Dipteran inclusive ortholog search EOG6H72KW Insect inclusive ortholog search EOG602VNK Arthropod inclusive ortholog search EOG6H9W2B Metazoa inclusive ortholog search EOG6RC3CK
Orthologs in Drosophila Species (EOG6ZW5WR)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\Octβ2R     Drosophila simulans   Dsim\GD20557 Y   Drosophila sechellia   Dsec\GM25999 Y   Drosophila erecta   Dere\GG17113 Y   Drosophila yakuba   Dyak\GE24503 Y   Drosophila ananassae   Dana\GF23002 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA26828 Y   Drosophila persimilis   Dper\GL13571 Y   Drosophila willistoni   Dwil\GK13569 Y   Drosophila virilis   Dvir\GJ10601 Y   Drosophila mojavensis   Dmoj\GI23111 Y   Drosophila grimshawi   Dgri\GH18896 Y
Orthologs in non-Drosophila Dipterans (EOG6H72KW)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL005945 Y Anopheles gambiae Malaria mosquito  Agam\GPRNNA2 Y Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ014487 Y
Orthologs in non-Dipteran Insects (EOG602VNK)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\oa2 Y Apis mellifera Western honey bee  Amel\GB49696 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG001703 Y Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH20860 Y Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH14340 Y Atta cephalotes Leafcutter ant  Acep\ACEP18896 Y Atta cephalotes Leafcutter ant  Acep\ACEP15017 Y Camponotus floridanus Florida carpenter ant  Cflo\CFLO14090 Y Camponotus floridanus Florida carpenter ant  Cflo\CFLO18779 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL18820 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL15966 Y Linepithema humile Argentine ant  Lhum\LH12970 Y Linepithema humile Argentine ant  Lhum\LH20188 Y Pogonomyrmex barbatus Red harvester ant  Pbar\PB23664 Y Pogonomyrmex barbatus Red harvester ant  Pbar\PB27222 Y Solenopsis invicta Red fire ant  Sinv\SINV24007 Y Solenopsis invicta Red fire ant  Sinv\SINV11870 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI004658 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI007386 Y Bombyx mori Silkmoth  Bmor\BmOAR2.1 Y Bombyx mori Silkmoth  Bmor\BGIBMGA002248 Y Pediculus humanus Human body louse  Phum\PHUM027040 Y Pediculus humanus Human body louse  Phum\PHUM497230 Y Tribolium castaneum Red flour beetle  Tcas\TC012600 Y Tribolium castaneum Red flour beetle  Tcas\TC012597 Y
Orthologs in non-Insect Arthropods (EOG6H9W2B)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\JGI_V11_347041 Y Ixodes scapularis Deer tick  Isca\ISCW008552 Y
Orthologs in non-Arthropod Metazoa (EOG6RC3CK)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Danio rerio Zebrafish  Drer\taar12i Y Danio rerio Zebrafish  Drer\taar12c Y Danio rerio Zebrafish  Drer\taar12b Y Danio rerio Zebrafish  Drer\taar12h Y Danio rerio Zebrafish  Drer\taar12a Y Danio rerio Zebrafish  Drer\taar12j Y Danio rerio Zebrafish  Drer\CU672229.1 Y Danio rerio Zebrafish  Drer\adra1ab Y Danio rerio Zebrafish  Drer\taar12e Y Danio rerio Zebrafish  Drer\taar12g Y Danio rerio Zebrafish  Drer\si:dkey-7c18.19 Y Xenopus tropicalis Western clawed frog  Xtro\ENSXETG00000010365 Y Gallus gallus Domestic chicken  Ggal\TAAR2 Y Mus musculus House mouse  Mmus\Taar2 Y Rattus norvegicus Norway rat  Rnor\Taar2 Y Rattus norvegicus Norway rat  Rnor\Taar7h Y Homo sapiens Human  Hsap\TAAR2 Y
Human Orthologs (1)
Gene OMIM HGNC Hsap\TAAR2
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD20557 Drosophila sechellia Dsec\GM25999 Drosophila erecta Dere\GG17113 Drosophila yakuba Dyak\GE24503 Drosophila ananassae Dana\GF23002 Drosophila pseudoobscura pseudoobscura Dpse\GA26828 Drosophila persimilis Dper\GL13571 Drosophila willistoni Dwil\GK13569 Drosophila virilis Dvir\GJ10601 Drosophila mojavensis Dmoj\GI23111 Drosophila grimshawi Dgri\GH18896
Stocks & Reagents
Stocks Listed in FlyBase ( 7 )
Bloomington	18896 w1118; PBac{WH}Octβ2Rf05679 37566 y1 w*; Mi{MIC}Octβ2RMI01794 34673 y1 sc* v1; P{TRiP.HMS01151}attP2
Harvard	- PBac{WH}Octβ2Rf05679
VDRC	v104050 P{KK112557}VIE-260B v104524 P{KK109808}VIE-260B v8486 w1118; P{GD2954}v8486
Genomic Clones ( 2 )
	BACR02G11 BACR07J06 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 10 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones
Other clones	IP21062
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	RH14041 RH27837 RH63355
Other clones	712 194796 CK01.146D.H9 EK120629 EK121921 RH22407
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0038063 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 41549
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: Octβ2R CG6989 CG18553 (Evans, 2005.2.16) Source for identity of: Octβ2R CG33976 (FlyBase Genome Annotators, 2005)
Source for database merge of	Source for merge of: CG6989 anon-WO0170980.184 anon-WO0170980.185 (FlyBase, 1996-) Source for merge of: CG6989 CG18553 (Evans, 2005.2.16, FlyBase Genome Annotators, 2005)
Additional comments	Source for merge of CG6989 anon-WO0170980.184 anon-WO0170980.185 was sequence comparison (date:051113). (FlyBase Genome Annotators, 2005, FlyBase, 1996-)
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_001038960 NM_001170125 NM_001260147 NM_001260148 NM_001260149 RefSeq (Proteins) • NP_001034049 NP_001163596 NP_001247076 NP_001247077 NP_001247078 DDBJ / EMBL / GenBank • AAF54834.1 AAF54835 AAF54835.1 ACZ94893 AFH06394 AFH06395 AFH06396 AJ880689 AX254617 AX254618 CAI56430 CZ488294 CZ488295 Entrez Gene - A searchable database of RefSeq genes. • 41549 UniProtKB/Swiss-Prot • Q4LBB9 UniProtKB/TrEMBL • E1JIJ4
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • G protein-coupled receptor, rhodopsin-like (IPR000276) Basic-leucine zipper domain (IPR004827) GPCR, rhodopsin-like, 7TM (IPR017452)
Linkouts
	BioGRID - A database of protein and genetic interactions • 66644 DroID - A comprehensive database of gene and protein interactions. • FBgn0038063 DRSC - Results from RNAi screens. • FBgn0038063 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0038063 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG6989-RA;CG18553-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0038063 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 41549 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 41549 modMine - Data generated by the modENCODE project. • FBgn0038063
Synonyms & Secondary IDs ( 12 )
Reported As
Symbol Synonym	anon-WO0170980.184   anon-WO0170980.185   CG6989 (Evans and Maqueira, 2005, Maqueira et al., 2005, Lai et al., 2003, Bryson-Richardson et al., 2004, Brody and Cravchik, 2000, Metpally and Sowdhamini, 2005) CG18553   CG33976 (FlyBase Genome Annotators, 2005, Keleman et al., 2009.8.5, Ni et al., 2010.12.1, Koon et al., 2011) DmCG6989 (Roeder et al., 2003) DmOctβ2R (Maqueira et al., 2005) OctB2R (Crocker et al., 2010) OctBeta2 (Evans, 2005.2.16) Octbeta2R (Izutsu et al., 2012, Jungreis et al., 2011, Brody, 2009.03) Octβ2R (Crocker et al., 2010, Koon and Budnik, 2012, Ohhara et al., 2012, Koon et al., 2011)
Name Synonym	octopamine β receptor (Crocker et al., 2010) Octβ2R
Secondary FlyBase IDs
	FBgn0038064 FBgn0046561 FBgn0046562 FBgn0053976 FBpp0082141 FBpp0082142 FBtr0082672 FBtr0082673
References ( 34 )
Generate a list of	All references relating to this gene ( 34 )
List References by type	Research paper  ( 11 ) Supplementary material  ( 5 ) Review  ( 2 ) Personal communication to FlyBase  ( 9 ) FlyBase analysis  ( 3 ) DNA/RNA sequence record  ( 1 ) Patent  ( 1 ) Curated genome annotation  ( 2 )
Recent research papers ( 5 )
	Burke et al., 2012, Nature 492(7429): 433--437 Layered reward signalling through octopamine and dopamine in Drosophila. [FBrf0220407] Izutsu et al., 2012, PLoS ONE 7(3): e33288 Genome features of "dark-fly", a Drosophila line reared long-term in a dark environment. [FBrf0217825] Koon and Budnik, 2012, J. Neurosci. 32(18): 6312--6322 Inhibitory control of synaptic and behavioral plasticity by octopaminergic signaling. [FBrf0218256] Ohhara et al., 2012, Zool. Sci., Tokyo 29(2): 83--89 Expression of β-adrenergic-like Octopamine Receptors during Drosophila Development. [FBrf0217397] Koon et al., 2011, Nat. Neurosci. 14(2): 190--199 Autoregulatory and paracrine control of synaptic and behavioral plasticity by octopaminergic signaling. [FBrf0212895] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...