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Gene Dmel\CG10126

General Information
Symbol	Dmel\CG10126	Species	D. melanogaster
Name		Annotation symbol	CG10126
Feature type	protein_coding_gene	FlyBase ID	FBgn0038088
Gene Model Status	Current	Stock availability	3 publicly available
Genomic Location
Chromosome (arm)	3R	Recombination map
Cytogenetic map	87D2-87D2	Sequence location	3R:8,681,266..8,684,968 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	This gene is referred to in FlyBase by the symbol Dmel\CG10126 (FBgn0038088). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: calcium ion binding. There is experimental evidence that it is involved in the biological process: neurogenesis. 2 alleles are reported. No phenotypic data is available. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: Calcium-binding EF-hand; EF-Hand 1, calcium-binding site; EF-hand-like domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of extremely low expression. Peak expression observed during late pupal stages, in adult male stages. Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult organs/tissues expressed at moderate or high levels. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, adult thoracico-abdominal ganglion, adult crop, adult hindgut, larval/adult Malpighian tubules, larval/adult salivary gland, larval trachea, adult spermathecae, adult male reproductive system, larval carcass. Expression at moderate levels in the following post-embryonic organs or tissues: larval/adult central nervous system, adult midgut, larval hindgut, adult heart, larval fat body, adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1627073_a_at completely aligns to an exonic region common to each of the 2 FlyBase-annotated transcript isoforms of CG10126. Gene sequence location is 3R:8681266..8684968.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 87D2-87D2   Limits computationally determined from genome sequence between P{lacW}Vha55j2E9 and P{PZ}CtBP03463
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\CG10126 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.48
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) CG10126-RA FBtr0082686  NM_141977   907   215 CG10126-RB FBtr0082687  NM_176487   835   227
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein CG10126-PA   FBpp0082154   24.4   215   4.22     NP_650234   AAF54868 CG10126-PB   FBpp0082155   25.9   227   4.40     NP_788664   AAO41493
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • EF-hand domain (IPR002048) EF-hand-like domain (IPR011992) EF-Hand 1, calcium-binding site (IPR018247)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014297 AAF54868   AE014297 AAO41493   AI109719   AI403534   AI946681   AW941852   AY060767 AAL28315   BE977762   BE978541   BT088991   CO154911   CO179016   CO299350   CO344909   EC073655   EC252651   EC261032
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q86PF4 Q9VG23
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 3   organism   (Fisher et al., 2012) Comment:maternally deposited embryonic stage 13 -- 16   embryonic dorsal epidermis   (Fisher et al., 2012) embryonic head epidermis   (Fisher et al., 2012) embryonic ventral epidermis   (Fisher et al., 2012) embryonic/larval posterior spiracle   (Fisher et al., 2012)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult organs/tissues expressed at moderate or high levels. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, adult thoracico-abdominal ganglion, adult crop, adult hindgut, larval/adult Malpighian tubules, larval/adult salivary gland, larval trachea, adult spermathecae, adult male reproductive system, larval carcass. Expression at moderate levels in the following post-embryonic organs or tissues: larval/adult central nervous system, adult midgut, larval hindgut, adult heart, larval fat body, adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    224.375 Larval Midgut    82.9 Larval Hindgut    489.4 Larval Malpighian Tubules    2004 Larval Fat Body    285.9 Larval Salivary Gland    4051.3 Larval Trachea    688.4 Larval Carcass    1688.925 Adult Head    941.6 Adult Eye    853.625 Adult Brain    340.6 Adult Thoracic-Abdominal Ganglion    579.9 Adult Crop    623.5 Adult Midgut    130.5 Adult Hindgut    692.4 Adult Malpighian Tubules    2478.8 Adult Fat Body    31.1 Adult Salivary Gland    3078.8 Adult Heart    321.075 Adult VirginFemale Spermatheca    1525.8 Adult InseminatedFemale Spermatheca    2509.9 Adult Ovary    23.2 Adult Testis    2146.3 Adult Male Accessory Gland    2569 Adult Carcass    411.6 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    224.375 Larval Midgut    82.9 Larval Hindgut    489.4 Larval Malpighian Tubules  (2004) Larval Fat Body    285.9 Larval Salivary Gland  (4051.3) Larval Trachea  (688.4) Larval Carcass  (1688.925) Adult Head  (941.6) Adult Eye  (853.625) Adult Brain    340.6 Adult Thoracic-Abdominal Ganglion  (579.9) Adult Crop  (623.5) Adult Midgut    130.5 Adult Hindgut  (692.4) Adult Malpighian Tubules  (2478.8) Adult Fat Body    31.1 Adult Salivary Gland  (3078.8) Adult Heart    321.075 Adult VirginFemale Spermatheca  (1525.8) Adult InseminatedFemale Spermatheca  (2509.9) Adult Ovary    23.2 Adult Testis  (2146.3) Adult Male Accessory Gland  (2569) Adult Carcass    411.6 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    224.375 Larval Midgut    82.9 Larval Hindgut    489.4 Larval Malpighian Tubules  (2004) Larval Fat Body    285.9 Larval Salivary Gland  (4051.3) Larval Trachea    688.4 Larval Carcass  (1688.925) Adult Head    941.6 Adult Eye    853.625 Adult Brain    340.6 Adult Thoracic-Abdominal Ganglion    579.9 Adult Crop    623.5 Adult Midgut    130.5 Adult Hindgut    692.4 Adult Malpighian Tubules  (2478.8) Adult Fat Body    31.1 Adult Salivary Gland  (3078.8) Adult Heart    321.075 Adult VirginFemale Spermatheca  (1525.8) Adult InseminatedFemale Spermatheca  (2509.9) Adult Ovary    23.2 Adult Testis  (2146.3) Adult Male Accessory Gland  (2569) Adult Carcass    411.6 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    224.375 Larval Midgut    82.9 Larval Hindgut    489.4 Larval Malpighian Tubules    2004 Larval Fat Body    285.9 Larval Salivary Gland    4051.3 Larval Trachea    688.4 Larval Carcass    1688.925 Adult Head    941.6 Adult Eye    853.625 Adult Brain    340.6 Adult Thoracic-Abdominal Ganglion    579.9 Adult Crop    623.5 Adult Midgut    130.5 Adult Hindgut    692.4 Adult Malpighian Tubules    2478.8 Adult Fat Body    31.1 Adult Salivary Gland    3078.8 Adult Heart    321.075 Adult VirginFemale Spermatheca    1525.8 Adult InseminatedFemale Spermatheca    2509.9 Adult Ovary    23.2 Adult Testis    2146.3 Adult Male Accessory Gland    2569 Adult Carcass    411.6 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    224.375 Larval Midgut    82.9 Larval Hindgut    489.4 Larval Malpighian Tubules    2004 Larval Fat Body    285.9 Larval Salivary Gland    4051.3 Larval Trachea    688.4 Larval Carcass    1688.925 Adult Head    941.6 Adult Eye    853.625 Adult Brain    340.6 Adult Thoracic-Abdominal Ganglion    579.9 Adult Crop    623.5 Adult Midgut    130.5 Adult Hindgut    692.4 Adult Malpighian Tubules    2478.8 Adult Fat Body    31.1 Adult Salivary Gland    3078.8 Adult Heart    321.075 Adult VirginFemale Spermatheca    1525.8 Adult InseminatedFemale Spermatheca    2509.9 Adult Ovary    23.2 Adult Testis    2146.3 Adult Male Accessory Gland    2569 Adult Carcass    411.6 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    224.375 Larval Midgut    82.9 Larval Hindgut    489.4 Larval Malpighian Tubules  (2004) Larval Fat Body    285.9 Larval Salivary Gland  (4051.3) Larval Trachea  688.4 Larval Carcass  (1688.925) Adult Head  (941.6) Adult Eye  (853.625) Adult Brain    340.6 Adult Thoracic-Abdominal Ganglion  579.9 Adult Crop  623.5 Adult Midgut    130.5 Adult Hindgut  692.4 Adult Malpighian Tubules  (2478.8) Adult Fat Body    31.1 Adult Salivary Gland  (3078.8) Adult Heart    321.075 Adult VirginFemale Spermatheca  (1525.8) Adult InseminatedFemale Spermatheca  (2509.9) Adult Ovary    23.2 Adult Testis  (2146.3) Adult Male Accessory Gland  (2569) Adult Carcass    411.6 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    224.375 Larval Midgut    82.9 Larval Hindgut    489.4 Larval Malpighian Tubules  (2004) Larval Fat Body    285.9 Larval Salivary Gland  (4051.3) Larval Trachea    688.4 Larval Carcass  1688.925 Adult Head    941.6 Adult Eye    853.625 Adult Brain    340.6 Adult Thoracic-Abdominal Ganglion    579.9 Adult Crop    623.5 Adult Midgut    130.5 Adult Hindgut    692.4 Adult Malpighian Tubules  (2478.8) Adult Fat Body    31.1 Adult Salivary Gland  (3078.8) Adult Heart    321.075 Adult VirginFemale Spermatheca  1525.8 Adult InseminatedFemale Spermatheca  (2509.9) Adult Ovary    23.2 Adult Testis  (2146.3) Adult Male Accessory Gland  (2569) Adult Carcass    411.6 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    224.375 Larval Midgut    82.9 Larval Hindgut    489.4 Larval Malpighian Tubules    2004 Larval Fat Body    285.9 Larval Salivary Gland    4051.3 Larval Trachea    688.4 Larval Carcass    1688.925 Adult Head    941.6 Adult Eye    853.625 Adult Brain    340.6 Adult Thoracic-Abdominal Ganglion    579.9 Adult Crop    623.5 Adult Midgut    130.5 Adult Hindgut    692.4 Adult Malpighian Tubules    2478.8 Adult Fat Body    31.1 Adult Salivary Gland    3078.8 Adult Heart    321.075 Adult VirginFemale Spermatheca    1525.8 Adult InseminatedFemale Spermatheca    2509.9 Adult Ovary    23.2 Adult Testis    2146.3 Adult Male Accessory Gland    2569 Adult Carcass    411.6 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    941.6   NA  Eye    853.625   NA  Brain    340.6   224.375  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    579.9   NA  Crop    623.5   82.9  Midgut    130.5   489.4  Hindgut    692.4   2004  Malpighian Tubules    2478.8   285.9  Fat Body    31.1   4051.3  Salivary Gland    3078.8   NA  Heart    321.075   688.4  Trachea    NA   NA  VirginFemale Spermatheca    1525.8   NA  InseminatedFemale Spermatheca    2509.9   NA  Ovary    23.2   NA  Testis    2146.3   NA  Male Accessory Gland    2569   1688.925  Carcass    411.6 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    43 central nervous system, larvae L3    26 central nervous system, pupae P8    8 head, virgin 1-day female    15 head, virgin 4-day female    26 head, virgin 20-day female    21 head, mated 1-day female    20 head, mated 4-day female    21 head, mated 20-day female    22 head, mated 1-day male    21 head, mated 4-day male    32 head, mated 20-day male    52 salivary gland, larvae L3 wandering    182 salivary gland, white prepupae    68 digestive system, larvae L3 wandering    16 digestive system, 1-day adult    26 digestive system, 4-day adult    23 digestive system, 20-day adult    31 fat body, larvae L3 wandering    1 fat body, white prepupae    13 fat body, pupae P8    19 carcass, larvae L3 wandering    87 carcass, 1-day adult    18 carcass, 4-day adult    23 carcass, 20-day adult    32 ovary, virgin 4-day female    2 ovary, mated 4-day female    3 testis, mated 4-day male    167 accessory gland, mated 4-day male    132 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (43) central nervous system, larvae L3  26 central nervous system, pupae P8    8 head, virgin 1-day female    15 head, virgin 4-day female  26 head, virgin 20-day female    21 head, mated 1-day female    20 head, mated 4-day female    21 head, mated 20-day female    22 head, mated 1-day male    21 head, mated 4-day male  (32) head, mated 20-day male  (52) salivary gland, larvae L3 wandering  (182) salivary gland, white prepupae  (68) digestive system, larvae L3 wandering    16 digestive system, 1-day adult  26 digestive system, 4-day adult    23 digestive system, 20-day adult  (31) fat body, larvae L3 wandering    1 fat body, white prepupae    13 fat body, pupae P8    19 carcass, larvae L3 wandering  (87) carcass, 1-day adult    18 carcass, 4-day adult    23 carcass, 20-day adult  (32) ovary, virgin 4-day female    2 ovary, mated 4-day female    3 testis, mated 4-day male  (167) accessory gland, mated 4-day male  (132) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    43 central nervous system, larvae L3    26 central nervous system, pupae P8    8 head, virgin 1-day female    15 head, virgin 4-day female    26 head, virgin 20-day female    21 head, mated 1-day female    20 head, mated 4-day female    21 head, mated 20-day female    22 head, mated 1-day male    21 head, mated 4-day male    32 head, mated 20-day male    52 salivary gland, larvae L3 wandering  (182) salivary gland, white prepupae    68 digestive system, larvae L3 wandering    16 digestive system, 1-day adult    26 digestive system, 4-day adult    23 digestive system, 20-day adult    31 fat body, larvae L3 wandering    1 fat body, white prepupae    13 fat body, pupae P8    19 carcass, larvae L3 wandering    87 carcass, 1-day adult    18 carcass, 4-day adult    23 carcass, 20-day adult    32 ovary, virgin 4-day female    2 ovary, mated 4-day female    3 testis, mated 4-day male  (167) accessory gland, mated 4-day male  (132) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    43 central nervous system, larvae L3    26 central nervous system, pupae P8    8 head, virgin 1-day female    15 head, virgin 4-day female    26 head, virgin 20-day female    21 head, mated 1-day female    20 head, mated 4-day female    21 head, mated 20-day female    22 head, mated 1-day male    21 head, mated 4-day male    32 head, mated 20-day male    52 salivary gland, larvae L3 wandering    182 salivary gland, white prepupae    68 digestive system, larvae L3 wandering    16 digestive system, 1-day adult    26 digestive system, 4-day adult    23 digestive system, 20-day adult    31 fat body, larvae L3 wandering    1 fat body, white prepupae    13 fat body, pupae P8    19 carcass, larvae L3 wandering    87 carcass, 1-day adult    18 carcass, 4-day adult    23 carcass, 20-day adult    32 ovary, virgin 4-day female    2 ovary, mated 4-day female    3 testis, mated 4-day male    167 accessory gland, mated 4-day male    132 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    43 central nervous system, larvae L3    26 central nervous system, pupae P8    8 head, virgin 1-day female    15 head, virgin 4-day female    26 head, virgin 20-day female    21 head, mated 1-day female    20 head, mated 4-day female    21 head, mated 20-day female    22 head, mated 1-day male    21 head, mated 4-day male    32 head, mated 20-day male    52 salivary gland, larvae L3 wandering    182 salivary gland, white prepupae    68 digestive system, larvae L3 wandering    16 digestive system, 1-day adult    26 digestive system, 4-day adult    23 digestive system, 20-day adult    31 fat body, larvae L3 wandering    1 fat body, white prepupae    13 fat body, pupae P8    19 carcass, larvae L3 wandering    87 carcass, 1-day adult    18 carcass, 4-day adult    23 carcass, 20-day adult    32 ovary, virgin 4-day female    2 ovary, mated 4-day female    3 testis, mated 4-day male    167 accessory gland, mated 4-day male    132 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (43) central nervous system, larvae L3  26 central nervous system, pupae P8    8 head, virgin 1-day female    15 head, virgin 4-day female  26 head, virgin 20-day female    21 head, mated 1-day female    20 head, mated 4-day female    21 head, mated 20-day female    22 head, mated 1-day male    21 head, mated 4-day male  32 head, mated 20-day male  (52) salivary gland, larvae L3 wandering  (182) salivary gland, white prepupae  (68) digestive system, larvae L3 wandering    16 digestive system, 1-day adult  26 digestive system, 4-day adult    23 digestive system, 20-day adult  31 fat body, larvae L3 wandering    1 fat body, white prepupae    13 fat body, pupae P8    19 carcass, larvae L3 wandering  (87) carcass, 1-day adult    18 carcass, 4-day adult    23 carcass, 20-day adult  32 ovary, virgin 4-day female    2 ovary, mated 4-day female    3 testis, mated 4-day male  (167) accessory gland, mated 4-day male  (132) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    43 central nervous system, larvae L3    26 central nervous system, pupae P8    8 head, virgin 1-day female    15 head, virgin 4-day female    26 head, virgin 20-day female    21 head, mated 1-day female    20 head, mated 4-day female    21 head, mated 20-day female    22 head, mated 1-day male    21 head, mated 4-day male    32 head, mated 20-day male    52 salivary gland, larvae L3 wandering  (182) salivary gland, white prepupae    68 digestive system, larvae L3 wandering    16 digestive system, 1-day adult    26 digestive system, 4-day adult    23 digestive system, 20-day adult    31 fat body, larvae L3 wandering    1 fat body, white prepupae    13 fat body, pupae P8    19 carcass, larvae L3 wandering    87 carcass, 1-day adult    18 carcass, 4-day adult    23 carcass, 20-day adult    32 ovary, virgin 4-day female    2 ovary, mated 4-day female    3 testis, mated 4-day male  (167) accessory gland, mated 4-day male  132 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    43 central nervous system, larvae L3    26 central nervous system, pupae P8    8 head, virgin 1-day female    15 head, virgin 4-day female    26 head, virgin 20-day female    21 head, mated 1-day female    20 head, mated 4-day female    21 head, mated 20-day female    22 head, mated 1-day male    21 head, mated 4-day male    32 head, mated 20-day male    52 salivary gland, larvae L3 wandering    182 salivary gland, white prepupae    68 digestive system, larvae L3 wandering    16 digestive system, 1-day adult    26 digestive system, 4-day adult    23 digestive system, 20-day adult    31 fat body, larvae L3 wandering    1 fat body, white prepupae    13 fat body, pupae P8    19 carcass, larvae L3 wandering    87 carcass, 1-day adult    18 carcass, 4-day adult    23 carcass, 20-day adult    32 ovary, virgin 4-day female    2 ovary, mated 4-day female    3 testis, mated 4-day male    167 accessory gland, mated 4-day male    132 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of extremely low expression. Peak expression observed during late pupal stages, in adult male stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    2 embryo 14-16hr    4 embryo 16-18hr    7 embryo 18-20hr    6 embryo 20-22hr    6 embryo 22-24hr    10 larva L1    7 larva L2    18 larva L3 12hr old    10 larva L3 puffstage 1-2    30 larva L3 puffstage 3-6    44 larva L3 puffstage 7-9    48 white prepupae new    27 white prepupae 12hr    43 white prepupae 24hr    48 pupae 2d postWPP    92 pupae 3d postWPP    68 pupae 4d postWPP    64 adult male 01day    76 adult male 05day    79 adult male 30day    89 adult female 01day    8 adult female 05day    6 adult female 30day    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    2 embryo 14-16hr    4 embryo 16-18hr    7 embryo 18-20hr    6 embryo 20-22hr    6 embryo 22-24hr    10 larva L1    7 larva L2    18 larva L3 12hr old    10 larva L3 puffstage 1-2  (30) larva L3 puffstage 3-6  (44) larva L3 puffstage 7-9  (48) white prepupae new  (27) white prepupae 12hr  (43) white prepupae 24hr  (48) pupae 2d postWPP  (92) pupae 3d postWPP  (68) pupae 4d postWPP  (64) adult male 01day  (76) adult male 05day  (79) adult male 30day  (89) adult female 01day    8 adult female 05day    6 adult female 30day    8 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    2 embryo 14-16hr    4 embryo 16-18hr    7 embryo 18-20hr    6 embryo 20-22hr    6 embryo 22-24hr    10 larva L1    7 larva L2    18 larva L3 12hr old    10 larva L3 puffstage 1-2    30 larva L3 puffstage 3-6    44 larva L3 puffstage 7-9    48 white prepupae new    27 white prepupae 12hr    43 white prepupae 24hr    48 pupae 2d postWPP    92 pupae 3d postWPP    68 pupae 4d postWPP    64 adult male 01day    76 adult male 05day    79 adult male 30day    89 adult female 01day    8 adult female 05day    6 adult female 30day    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    2 embryo 14-16hr    4 embryo 16-18hr    7 embryo 18-20hr    6 embryo 20-22hr    6 embryo 22-24hr    10 larva L1    7 larva L2    18 larva L3 12hr old    10 larva L3 puffstage 1-2    30 larva L3 puffstage 3-6    44 larva L3 puffstage 7-9    48 white prepupae new    27 white prepupae 12hr    43 white prepupae 24hr    48 pupae 2d postWPP    92 pupae 3d postWPP    68 pupae 4d postWPP    64 adult male 01day    76 adult male 05day    79 adult male 30day    89 adult female 01day    8 adult female 05day    6 adult female 30day    8 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    2 embryo 14-16hr    4 embryo 16-18hr    7 embryo 18-20hr    6 embryo 20-22hr    6 embryo 22-24hr    10 larva L1    7 larva L2    18 larva L3 12hr old    10 larva L3 puffstage 1-2    30 larva L3 puffstage 3-6    44 larva L3 puffstage 7-9    48 white prepupae new    27 white prepupae 12hr    43 white prepupae 24hr    48 pupae 2d postWPP    92 pupae 3d postWPP    68 pupae 4d postWPP    64 adult male 01day    76 adult male 05day    79 adult male 30day    89 adult female 01day    8 adult female 05day    6 adult female 30day    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    2 embryo 14-16hr    4 embryo 16-18hr    7 embryo 18-20hr    6 embryo 20-22hr    6 embryo 22-24hr    10 larva L1    7 larva L2    18 larva L3 12hr old    10 larva L3 puffstage 1-2  30 larva L3 puffstage 3-6  (44) larva L3 puffstage 7-9  (48) white prepupae new  27 white prepupae 12hr  (43) white prepupae 24hr  (48) pupae 2d postWPP  (92) pupae 3d postWPP  (68) pupae 4d postWPP  (64) adult male 01day  (76) adult male 05day  (79) adult male 30day  (89) adult female 01day    8 adult female 05day    6 adult female 30day    8 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    2 embryo 14-16hr    4 embryo 16-18hr    7 embryo 18-20hr    6 embryo 20-22hr    6 embryo 22-24hr    10 larva L1    7 larva L2    18 larva L3 12hr old    10 larva L3 puffstage 1-2    30 larva L3 puffstage 3-6    44 larva L3 puffstage 7-9    48 white prepupae new    27 white prepupae 12hr    43 white prepupae 24hr    48 pupae 2d postWPP    92 pupae 3d postWPP    68 pupae 4d postWPP    64 adult male 01day    76 adult male 05day    79 adult male 30day    89 adult female 01day    8 adult female 05day    6 adult female 30day    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    2 embryo 14-16hr    4 embryo 16-18hr    7 embryo 18-20hr    6 embryo 20-22hr    6 embryo 22-24hr    10 larva L1    7 larva L2    18 larva L3 12hr old    10 larva L3 puffstage 1-2    30 larva L3 puffstage 3-6    44 larva L3 puffstage 7-9    48 white prepupae new    27 white prepupae 12hr    43 white prepupae 24hr    48 pupae 2d postWPP    92 pupae 3d postWPP    68 pupae 4d postWPP    64 adult male 01day    76 adult male 05day    79 adult male 30day    89 adult female 01day    8 adult female 05day    6 adult female 30day    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    20 Schneider line 2 Sg4    108 embryonic 1182-4H    153 embryonic GM2    173 embryonic Kc167    3 embryonic S1    24 embryonic S3    1 leg disc CME L1    155 wing disc CME-W2    37 wing disc ML-DmD8    71 wing disc ML-DmD9    134 wing disc ML-DmD16-c3    32 wing disc ML-DmD21    57 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    1 eye-antennal disc ML-DmD11    101 antennal disc ML-DmD20-c5    92 mixed discs ML-DmD4-c1    141 CNS ML-DmBG1-c1    234 CNS ML-DmBG2-c2    169 tumorous blood cells mbn2    13 ovary fGS/OSS    10 ovary OSC    4 ovary OSS    84 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    20 Schneider line 2 Sg4  (108) embryonic 1182-4H  (153) embryonic GM2  (173) embryonic Kc167    3 embryonic S1    24 embryonic S3    1 leg disc CME L1  (155) wing disc CME-W2  (37) wing disc ML-DmD8  (71) wing disc ML-DmD9  (134) wing disc ML-DmD16-c3  (32) wing disc ML-DmD21  (57) wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    1 eye-antennal disc ML-DmD11  (101) antennal disc ML-DmD20-c5  (92) mixed discs ML-DmD4-c1  (141) CNS ML-DmBG1-c1  (234) CNS ML-DmBG2-c2  (169) tumorous blood cells mbn2    13 ovary fGS/OSS    10 ovary OSC    4 ovary OSS  (84) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    20 Schneider line 2 Sg4  (108) embryonic 1182-4H  (153) embryonic GM2  (173) embryonic Kc167    3 embryonic S1    24 embryonic S3    1 leg disc CME L1  (155) wing disc CME-W2    37 wing disc ML-DmD8    71 wing disc ML-DmD9  (134) wing disc ML-DmD16-c3    32 wing disc ML-DmD21    57 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    1 eye-antennal disc ML-DmD11  101 antennal disc ML-DmD20-c5    92 mixed discs ML-DmD4-c1  (141) CNS ML-DmBG1-c1  (234) CNS ML-DmBG2-c2  (169) tumorous blood cells mbn2    13 ovary fGS/OSS    10 ovary OSC    4 ovary OSS    84 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    20 Schneider line 2 Sg4    108 embryonic 1182-4H    153 embryonic GM2    173 embryonic Kc167    3 embryonic S1    24 embryonic S3    1 leg disc CME L1    155 wing disc CME-W2    37 wing disc ML-DmD8    71 wing disc ML-DmD9    134 wing disc ML-DmD16-c3    32 wing disc ML-DmD21    57 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    1 eye-antennal disc ML-DmD11    101 antennal disc ML-DmD20-c5    92 mixed discs ML-DmD4-c1    141 CNS ML-DmBG1-c1    234 CNS ML-DmBG2-c2    169 tumorous blood cells mbn2    13 ovary fGS/OSS    10 ovary OSC    4 ovary OSS    84 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    20 Schneider line 2 Sg4    108 embryonic 1182-4H    153 embryonic GM2    173 embryonic Kc167    3 embryonic S1    24 embryonic S3    1 leg disc CME L1    155 wing disc CME-W2    37 wing disc ML-DmD8    71 wing disc ML-DmD9    134 wing disc ML-DmD16-c3    32 wing disc ML-DmD21    57 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    1 eye-antennal disc ML-DmD11    101 antennal disc ML-DmD20-c5    92 mixed discs ML-DmD4-c1    141 CNS ML-DmBG1-c1    234 CNS ML-DmBG2-c2    169 tumorous blood cells mbn2    13 ovary fGS/OSS    10 ovary OSC    4 ovary OSS    84 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    20 Schneider line 2 Sg4  (108) embryonic 1182-4H  (153) embryonic GM2  (173) embryonic Kc167    3 embryonic S1    24 embryonic S3    1 leg disc CME L1  (155) wing disc CME-W2  (37) wing disc ML-DmD8  (71) wing disc ML-DmD9  (134) wing disc ML-DmD16-c3  32 wing disc ML-DmD21  (57) wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    1 eye-antennal disc ML-DmD11  (101) antennal disc ML-DmD20-c5  (92) mixed discs ML-DmD4-c1  (141) CNS ML-DmBG1-c1  (234) CNS ML-DmBG2-c2  (169) tumorous blood cells mbn2    13 ovary fGS/OSS    10 ovary OSC    4 ovary OSS  (84) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    20 Schneider line 2 Sg4  108 embryonic 1182-4H  (153) embryonic GM2  (173) embryonic Kc167    3 embryonic S1    24 embryonic S3    1 leg disc CME L1  (155) wing disc CME-W2    37 wing disc ML-DmD8    71 wing disc ML-DmD9  134 wing disc ML-DmD16-c3    32 wing disc ML-DmD21    57 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    1 eye-antennal disc ML-DmD11  101 antennal disc ML-DmD20-c5    92 mixed discs ML-DmD4-c1  141 CNS ML-DmBG1-c1  (234) CNS ML-DmBG2-c2  (169) tumorous blood cells mbn2    13 ovary fGS/OSS    10 ovary OSC    4 ovary OSS    84 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    20 Schneider line 2 Sg4    108 embryonic 1182-4H    153 embryonic GM2    173 embryonic Kc167    3 embryonic S1    24 embryonic S3    1 leg disc CME L1    155 wing disc CME-W2    37 wing disc ML-DmD8    71 wing disc ML-DmD9    134 wing disc ML-DmD16-c3    32 wing disc ML-DmD21    57 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    1 eye-antennal disc ML-DmD11    101 antennal disc ML-DmD20-c5    92 mixed discs ML-DmD4-c1    141 CNS ML-DmBG1-c1    234 CNS ML-DmBG2-c2    169 tumorous blood cells mbn2    13 ovary fGS/OSS    10 ovary OSC    4 ovary OSS    84 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    25 cold shock, 4-day adult    30 heat shock, 4-day adult    22 Cadmium 50 mM 6 hrs, larvae L3    30 Cadmium 50 mM 12 hrs, larvae L3    90 Cadmium 50 mM 48 hrs, 4-day adult    27 Cadmium 100 mM 48 hrs, 4-day adult    47 Copper 0.5 mM 12 hrs, larvae L3    31 Copper 15 mM 48 hrs, 4-day adult    33 Zinc 5 mM 12 hrs, larvae L3    37 Zinc 4.5 mM 48 hrs, 4-day adult    67 Ethanol 2.5% 3 hrs, larvae L3    29 Ethanol 5% 3 hrs, larvae L3    52 Ethanol 10% 3 hrs, larvae L3    34 Caffeine 1.5 mg/ml 4 hrs, larvae L3    37 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    26 Caffeine 25 mg/ml 48 hrs, 4-day adult    28 Paraquat 5 mM 48 hrs, 4-day adult    35 Paraquat 10 mM 48 hrs, 4-day adult    43 Rotenone 2 μg 12 hrs, larvae L3    33 Rotenone 8 μg 12 hrs, larvae L3    21 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    25 cold shock, 4-day adult  (30) heat shock, 4-day adult    22 Cadmium 50 mM 6 hrs, larvae L3  (30) Cadmium 50 mM 12 hrs, larvae L3  (90) Cadmium 50 mM 48 hrs, 4-day adult  (27) Cadmium 100 mM 48 hrs, 4-day adult  (47) Copper 0.5 mM 12 hrs, larvae L3  (31) Copper 15 mM 48 hrs, 4-day adult  (33) Zinc 5 mM 12 hrs, larvae L3  (37) Zinc 4.5 mM 48 hrs, 4-day adult  (67) Ethanol 2.5% 3 hrs, larvae L3  (29) Ethanol 5% 3 hrs, larvae L3  (52) Ethanol 10% 3 hrs, larvae L3  (34) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (37) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  26 Caffeine 25 mg/ml 48 hrs, 4-day adult  (28) Paraquat 5 mM 48 hrs, 4-day adult  (35) Paraquat 10 mM 48 hrs, 4-day adult  (43) Rotenone 2 μg 12 hrs, larvae L3  (33) Rotenone 8 μg 12 hrs, larvae L3    21 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    25 cold shock, 4-day adult    30 heat shock, 4-day adult    22 Cadmium 50 mM 6 hrs, larvae L3    30 Cadmium 50 mM 12 hrs, larvae L3    90 Cadmium 50 mM 48 hrs, 4-day adult    27 Cadmium 100 mM 48 hrs, 4-day adult    47 Copper 0.5 mM 12 hrs, larvae L3    31 Copper 15 mM 48 hrs, 4-day adult    33 Zinc 5 mM 12 hrs, larvae L3    37 Zinc 4.5 mM 48 hrs, 4-day adult    67 Ethanol 2.5% 3 hrs, larvae L3    29 Ethanol 5% 3 hrs, larvae L3    52 Ethanol 10% 3 hrs, larvae L3    34 Caffeine 1.5 mg/ml 4 hrs, larvae L3    37 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    26 Caffeine 25 mg/ml 48 hrs, 4-day adult    28 Paraquat 5 mM 48 hrs, 4-day adult    35 Paraquat 10 mM 48 hrs, 4-day adult    43 Rotenone 2 μg 12 hrs, larvae L3    33 Rotenone 8 μg 12 hrs, larvae L3    21 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    25 cold shock, 4-day adult    30 heat shock, 4-day adult    22 Cadmium 50 mM 6 hrs, larvae L3    30 Cadmium 50 mM 12 hrs, larvae L3    90 Cadmium 50 mM 48 hrs, 4-day adult    27 Cadmium 100 mM 48 hrs, 4-day adult    47 Copper 0.5 mM 12 hrs, larvae L3    31 Copper 15 mM 48 hrs, 4-day adult    33 Zinc 5 mM 12 hrs, larvae L3    37 Zinc 4.5 mM 48 hrs, 4-day adult    67 Ethanol 2.5% 3 hrs, larvae L3    29 Ethanol 5% 3 hrs, larvae L3    52 Ethanol 10% 3 hrs, larvae L3    34 Caffeine 1.5 mg/ml 4 hrs, larvae L3    37 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    26 Caffeine 25 mg/ml 48 hrs, 4-day adult    28 Paraquat 5 mM 48 hrs, 4-day adult    35 Paraquat 10 mM 48 hrs, 4-day adult    43 Rotenone 2 μg 12 hrs, larvae L3    33 Rotenone 8 μg 12 hrs, larvae L3    21 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    25 cold shock, 4-day adult    30 heat shock, 4-day adult    22 Cadmium 50 mM 6 hrs, larvae L3    30 Cadmium 50 mM 12 hrs, larvae L3    90 Cadmium 50 mM 48 hrs, 4-day adult    27 Cadmium 100 mM 48 hrs, 4-day adult    47 Copper 0.5 mM 12 hrs, larvae L3    31 Copper 15 mM 48 hrs, 4-day adult    33 Zinc 5 mM 12 hrs, larvae L3    37 Zinc 4.5 mM 48 hrs, 4-day adult    67 Ethanol 2.5% 3 hrs, larvae L3    29 Ethanol 5% 3 hrs, larvae L3    52 Ethanol 10% 3 hrs, larvae L3    34 Caffeine 1.5 mg/ml 4 hrs, larvae L3    37 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    26 Caffeine 25 mg/ml 48 hrs, 4-day adult    28 Paraquat 5 mM 48 hrs, 4-day adult    35 Paraquat 10 mM 48 hrs, 4-day adult    43 Rotenone 2 μg 12 hrs, larvae L3    33 Rotenone 8 μg 12 hrs, larvae L3    21 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    25 cold shock, 4-day adult  30 heat shock, 4-day adult    22 Cadmium 50 mM 6 hrs, larvae L3  30 Cadmium 50 mM 12 hrs, larvae L3  (90) Cadmium 50 mM 48 hrs, 4-day adult  27 Cadmium 100 mM 48 hrs, 4-day adult  (47) Copper 0.5 mM 12 hrs, larvae L3  31 Copper 15 mM 48 hrs, 4-day adult  (33) Zinc 5 mM 12 hrs, larvae L3  (37) Zinc 4.5 mM 48 hrs, 4-day adult  (67) Ethanol 2.5% 3 hrs, larvae L3  29 Ethanol 5% 3 hrs, larvae L3  (52) Ethanol 10% 3 hrs, larvae L3  (34) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (37) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  26 Caffeine 25 mg/ml 48 hrs, 4-day adult  28 Paraquat 5 mM 48 hrs, 4-day adult  (35) Paraquat 10 mM 48 hrs, 4-day adult  (43) Rotenone 2 μg 12 hrs, larvae L3  (33) Rotenone 8 μg 12 hrs, larvae L3    21 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    25 cold shock, 4-day adult    30 heat shock, 4-day adult    22 Cadmium 50 mM 6 hrs, larvae L3    30 Cadmium 50 mM 12 hrs, larvae L3    90 Cadmium 50 mM 48 hrs, 4-day adult    27 Cadmium 100 mM 48 hrs, 4-day adult    47 Copper 0.5 mM 12 hrs, larvae L3    31 Copper 15 mM 48 hrs, 4-day adult    33 Zinc 5 mM 12 hrs, larvae L3    37 Zinc 4.5 mM 48 hrs, 4-day adult    67 Ethanol 2.5% 3 hrs, larvae L3    29 Ethanol 5% 3 hrs, larvae L3    52 Ethanol 10% 3 hrs, larvae L3    34 Caffeine 1.5 mg/ml 4 hrs, larvae L3    37 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    26 Caffeine 25 mg/ml 48 hrs, 4-day adult    28 Paraquat 5 mM 48 hrs, 4-day adult    35 Paraquat 10 mM 48 hrs, 4-day adult    43 Rotenone 2 μg 12 hrs, larvae L3    33 Rotenone 8 μg 12 hrs, larvae L3    21 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    25 cold shock, 4-day adult    30 heat shock, 4-day adult    22 Cadmium 50 mM 6 hrs, larvae L3    30 Cadmium 50 mM 12 hrs, larvae L3    90 Cadmium 50 mM 48 hrs, 4-day adult    27 Cadmium 100 mM 48 hrs, 4-day adult    47 Copper 0.5 mM 12 hrs, larvae L3    31 Copper 15 mM 48 hrs, 4-day adult    33 Zinc 5 mM 12 hrs, larvae L3    37 Zinc 4.5 mM 48 hrs, 4-day adult    67 Ethanol 2.5% 3 hrs, larvae L3    29 Ethanol 5% 3 hrs, larvae L3    52 Ethanol 10% 3 hrs, larvae L3    34 Caffeine 1.5 mg/ml 4 hrs, larvae L3    37 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    26 Caffeine 25 mg/ml 48 hrs, 4-day adult    28 Paraquat 5 mM 48 hrs, 4-day adult    35 Paraquat 10 mM 48 hrs, 4-day adult    43 Rotenone 2 μg 12 hrs, larvae L3    33 Rotenone 8 μg 12 hrs, larvae L3    21 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_04
External Data & Images
Linkouts	BDGP expression data • GH22994 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0038088 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG10126-RB
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal CG10126GD6638 lethal | pupal stage, with Scer\GAL4pnr-MD237 CG10126GD6638 partially lethal - majority die | pupal stage, with Scer\GAL4pnr-MD237 CG10126GD6638 Other Phenotypes Allele neuroanatomy defective | larval stage CG10126GD6638 Phenotype manifest in Allele embryonic/larval neuroblast | larval stage CG10126GD6638 ganglion mother cell | larval stage CG10126GD6638
Classical Alleles ( 0 )
For All Classical Alleles Show
Allele of CG10126 Class Mutagen Stocks Known lesion
Alleles Carried on Transgenic Constructs ( 2 )
For All Alleles Carried on Transgenic Constructs Show
Allele of CG10126 Class Mutagen Stocks Known lesion CG10126GD6638 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes CG10126KK111654 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes
Aneuploid Aberrations
Disrupted in	Df(3R)Exel7318 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD6638} NA P{KK111654} NA
Insertions
	Type of insertions Name Expression data
Gene Ontology: Function, Process & Cellular Component ( 2 unique terms )
Terms Based on Experimental Evidence ( 1 term )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
neurogenesis inferred from mutant phenotype (Neumüller et al., 2011)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 1 term )
Molecular Function
CV term Evidence References
calcium ion binding inferred from sequence or structural similarity with UniProtKB:P80363 (FlyBase, 1992-)
Biological Process ( 0 terms)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
CG10126 - CG6020 anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based (Mintseris et al., 2009.11.23, Guruharsha et al., 2011) CG10126 - Smn anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based (Mintseris et al., 2009.11.23, Guruharsha et al., 2011) CG10126 - rux experimental knowledge based, anti tag coimmunoprecipitation, peptide massfingerprinting (Guruharsha et al., 2011, Mintseris et al., 2009.11.23)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions CG10126 allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 66670 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0038088 DroID - A comprehensive database of gene and protein interactions. • FBgn0038088 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 41579
Orthologs
OrthoDB Orthologs (42) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG63R472 Dipteran inclusive ortholog search EOG60CHRV Insect inclusive ortholog search EOG6BCCHV Arthropod inclusive ortholog search EOG6PC87X Metazoa inclusive ortholog search EOG6XQ39W
Orthologs in Drosophila Species (EOG63R472)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\CG10126     Drosophila simulans   Dsim\GD20537 Y   Drosophila sechellia   Dsec\GM25975 Y   Drosophila erecta   Dere\GG17094 Y   Drosophila yakuba   Dyak\GE24482 Y   Drosophila ananassae   Dana\GF18095 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA27168 Y   Drosophila persimilis   Dper\GL23159 Y   Drosophila willistoni   Dwil\GK10861 Y   Drosophila virilis   Dvir\GJ10812 Y   Drosophila mojavensis   Dmoj\GI24237 Y   Drosophila grimshawi   Dgri\GH19205 Y
Orthologs in non-Drosophila Dipterans (EOG60CHRV)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL008489 Y Anopheles gambiae Malaria mosquito  Agam\AGAP007666 Y Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ000193 Y
Orthologs in non-Dipteran Insects (EOG6BCCHV)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB41806 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG013447 Y Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH15970 Y Atta cephalotes Leafcutter ant  Acep\ACEP14664 Y Camponotus floridanus Florida carpenter ant  Cflo\CFLO23231 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL15523 Y Linepithema humile Argentine ant  Lhum\LH14331 Y Pogonomyrmex barbatus Red harvester ant  Pbar\PB10902 Y Solenopsis invicta Red fire ant  Sinv\SINV18177 Y Bombyx mori Silkmoth  Bmor\BGIBMGA000232 Y Pediculus humanus Human body louse  Phum\PHUM401590 Y Tribolium castaneum Red flour beetle  Tcas\TC014014 Y
Orthologs in non-Insect Arthropods (EOG6PC87X)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\Acot1 Y Daphnia pulex Water flea  Dpux\JGI_V11_228861 Y Daphnia pulex Water flea  Dpux\JGI_V11_322610 Y Daphnia pulex Water flea  Dpux\JGI_V11_305777 Y Ixodes scapularis Deer tick  Isca\ISCW021456 Y
Orthologs in non-Arthropod Metazoa (EOG6XQ39W)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_027158gn Y Danio rerio Zebrafish  Drer\capslb Y Danio rerio Zebrafish  Drer\capsla Y Xenopus tropicalis Western clawed frog  Xtro\capsl Y Xenopus tropicalis Western clawed frog  Xtro\caps Y Gallus gallus Domestic chicken  Ggal\CAPSL Y Mus musculus House mouse  Mmus\Capsl Y Rattus norvegicus Norway rat  Rnor\Capsl Y Homo sapiens Human  Hsap\CAPSL Y Homo sapiens Human  Hsap\FLJ00390 Y
Human Orthologs (2)
Gene OMIM HGNC Hsap\CAPSL     Hsap\FLJ00390
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD20537 Drosophila sechellia Dsec\GM25975 Drosophila erecta Dere\GG17094 Drosophila yakuba Dyak\GE24482 Drosophila ananassae Dana\GF18095 Drosophila pseudoobscura pseudoobscura Dpse\GA27168 Drosophila persimilis Dper\GL23159 Drosophila willistoni Dwil\GK10861 Drosophila virilis Dvir\GJ10812 Drosophila mojavensis Dmoj\GI24237 Drosophila grimshawi Dgri\GH19205
Stocks & Reagents
Stocks Listed in FlyBase ( 3 )
VDRC	v102435 P{KK111654}VIE-260B v44104 w1118; P{GD6638}v44104 v44103 w1118; P{GD6638}v44103/CyO
Genomic Clones ( 2 )
	BACR09O13 BACR17F05 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 13 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GH22994
Other clones	DPiM_GH22994 GH08978
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones
Other clones	47278 214469.34 524245 bs29e07 bs68g06 bs79a11 EK058203 EK175138 EN05024 EP20354
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0038088 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 41579
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_141977 NM_176487 RefSeq (Proteins) • NP_650234 NP_788664 DDBJ / EMBL / GenBank • AAF54868 AAL28315 AAO41493 AI109719 AI403534 AI946681 AW941852 AY060767 Entrez Gene - A searchable database of RefSeq genes. • 41579 UniProtKB/TrEMBL • Q9VG23 Q86PF4
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • EF-hand domain (IPR002048) EF-hand-like domain (IPR011992) EF-Hand 1, calcium-binding site (IPR018247) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • GH22994
Linkouts
	BioGRID - A database of protein and genetic interactions • 66670 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0038088 DroID - A comprehensive database of gene and protein interactions. • FBgn0038088 DRSC - Results from RNAi screens. • FBgn0038088 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0038088 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG10126-RB FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0038088 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 41579 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 41579 modMine - Data generated by the modENCODE project. • FBgn0038088
Synonyms & Secondary IDs ( 2 )
Reported As
Symbol Synonym	CG10126 (Blanco et al., 2010, Keleman et al., 2009.8.5, Cherbas et al., 2011) CT28495 (Ceriani et al., 2002)
Name Synonym
Secondary FlyBase IDs
References ( 20 )
Research paper	Cherbas et al., 2011, Genome Res. 21(2): 301--314 The transcriptional diversity of 25 Drosophila cell lines. [FBrf0213077] Blanco et al., 2010, BMC Dev. Biol. 10: 94 Gene expression following induction of regeneration in Drosophila wing imaginal discs. Expression profile of regenerating wing discs. [FBrf0211812] Butler et al., 2003, Development 130(4): 659--670 Discovery of genes with highly restricted expression patterns in the Drosophila wing disc using DNA oligonucleotide microarrays. [FBrf0155718] Ceriani et al., 2002, J. Neurosci. 22(21): 9305--9319 Genome-wide expression analysis in Drosophila reveals genes controlling circadian behavior. [FBrf0152147]
Supplementary material	Guruharsha et al., 2011, Cell 147(3): Table S3. [FBrf0218395] Neumüller et al., 2011, Cell Stem Cell 8(5): Supplemental Table S1. [FBrf0214431] The modENCODE Consortium, 2010, Science 330(6012): DataS14: Gene co-expression clusters. [FBrf0213979] Mummery-Widmer et al., 2009, Nature 458(7241): Supplementary Table 2 - Genome-wide bristle screen results. [FBrf0214518] Giot et al., 2003, Science 302(5651): Tables S1 to S7. [FBrf0166452]
Personal communication to FlyBase	Keleman et al., 2009.8.5, RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0208510] Mintseris et al., 2009.11.23, DPiM: the Drosophila Protein Interaction Mapping project DPiM: the Drosophila Protein Interaction Mapping project [FBrf0209452] Dickson et al., 2007.7.18, RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0200327] Ryder, 2004.4.26, Exelixis CG deletion data. Exelixis CG deletion data. [FBrf0184335] Oliver, 2001.8.16, Genome Res.: File from B. Oliver containing information on ESTs expressed in the Drosophila testis, described in Andrews et al., 2000, Genome Res. 10(12): 2030-2043 (FBrf0132348). [FBrf0137492] BDGP Project Members, 2000-, Berkeley Drosophila Genome Project. (Computer file) Berkeley Drosophila Genome Project. (Computer file) [FBrf0125078]
FlyBase analysis	FlyBase, 1992-, FlyBase curation. FlyBase curation. [FBrf0105495]
Website	Fisher et al., 2012, BDGP insitu homepage BDGP insitu homepage [FBrf0219073]
Curated genome annotation	FamiliarityBreedsContempt, 1999.11, [Automatic annotations performed at the Celera Jamboreee.] [Automatic annotations performed at the Celera Jamboreee.] [FBrf0126705] Milshina, 1999.11, [Annotations performed at the Celera Jamboreee.] [Annotations performed at the Celera Jamboreee.] [FBrf0126686]