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Gene Dmel\Ravus

General Information
Symbol	Dmel\Ravus	Species	D. melanogaster
Name	Ravus	Annotation symbol	CG15889
Feature type	protein_coding_gene	FlyBase ID	FBgn0038128
Gene Model Status	Current	Stock availability	4 publicly available
Genomic Location
Chromosome (arm)	3R	Recombination map
Cytogenetic map	87E3-87E3	Sequence location	3R:9,088,454..9,089,783 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Ravus is referred to in FlyBase by the symbol Dmel\Ravus (CG15889, FBgn0038128). It is a protein_coding_gene from Drosophila melanogaster. An electronic pipeline based on InterPro domains suggests that it has the molecular function: DNA binding. The biological processes in which it is involved are not known. 4 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: BESS motif. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of low expression. Peak expression observed at stages throughout embryogenesis, during late larval stages, at stages throughout the pupal period, in stages of adults of both sexes. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult ovary. Comments on Affy2 ProbeSet: ProbeSet 1628065_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of Ravus. Gene sequence location is 3R:9088454..9089783.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 87E3-87E3   Limits computationally determined from genome sequence between P{PZ}CtBP03463 and P{lacW}B52s2249&P{lacW}flflL4179
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Ravus for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.47
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Ravus-RA FBtr0082779  NM_169498   1270   359
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Ravus-PA   FBpp0082247   39.5   359   4.51     NP_731779   AAF54917
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • BESS motif (IPR004210)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014297 AAF54917   AI945024   AY121653 AAM51980   BI162617   BI162618   BI616798   BI635605   BT126297   CK661925   CO185457   CO313251   EC057017   EC248480   GH803041   GH842207   GH875590   GH890423
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9VFX8 Q8MRD3
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 3   organism   (Fisher et al., 2012) Comment:maternally deposited embryonic stage 4 -- 6   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 7 -- 8   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 9 -- 10   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 11 -- 12   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 13 -- 16   organism | ubiquitous   (Fisher et al., 2012)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
colocalizes_with nuclear chromatin inferred from direct assay (Delattre et al., 2002)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult ovary. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    60.45 Larval Midgut    34.7 Larval Hindgut    40.2 Larval Malpighian Tubules    68.5 Larval Fat Body    47.1 Larval Salivary Gland    51.7 Larval Trachea    32.7 Larval Carcass    28.475 Adult Head    33.2 Adult Eye    24.125 Adult Brain    72.9 Adult Thoracic-Abdominal Ganglion    49.3 Adult Crop    32.4 Adult Midgut    24.5 Adult Hindgut    35.1 Adult Malpighian Tubules    39.7 Adult Fat Body    28.3 Adult Salivary Gland    23.7 Adult Heart    25.925 Adult VirginFemale Spermatheca    26.8 Adult InseminatedFemale Spermatheca    33.7 Adult Ovary    120.7 Adult Testis    54.4 Adult Male Accessory Gland    30.5 Adult Carcass    36.6 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    60.45 Larval Midgut    34.7 Larval Hindgut    40.2 Larval Malpighian Tubules    68.5 Larval Fat Body    47.1 Larval Salivary Gland    51.7 Larval Trachea    32.7 Larval Carcass    28.475 Adult Head    33.2 Adult Eye    24.125 Adult Brain    72.9 Adult Thoracic-Abdominal Ganglion    49.3 Adult Crop    32.4 Adult Midgut    24.5 Adult Hindgut    35.1 Adult Malpighian Tubules    39.7 Adult Fat Body    28.3 Adult Salivary Gland    23.7 Adult Heart    25.925 Adult VirginFemale Spermatheca    26.8 Adult InseminatedFemale Spermatheca    33.7 Adult Ovary    120.7 Adult Testis    54.4 Adult Male Accessory Gland    30.5 Adult Carcass    36.6 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    60.45 Larval Midgut    34.7 Larval Hindgut    40.2 Larval Malpighian Tubules    68.5 Larval Fat Body    47.1 Larval Salivary Gland    51.7 Larval Trachea    32.7 Larval Carcass    28.475 Adult Head    33.2 Adult Eye    24.125 Adult Brain    72.9 Adult Thoracic-Abdominal Ganglion    49.3 Adult Crop    32.4 Adult Midgut    24.5 Adult Hindgut    35.1 Adult Malpighian Tubules    39.7 Adult Fat Body    28.3 Adult Salivary Gland    23.7 Adult Heart    25.925 Adult VirginFemale Spermatheca    26.8 Adult InseminatedFemale Spermatheca    33.7 Adult Ovary    120.7 Adult Testis    54.4 Adult Male Accessory Gland    30.5 Adult Carcass    36.6 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    60.45 Larval Midgut    34.7 Larval Hindgut    40.2 Larval Malpighian Tubules    68.5 Larval Fat Body    47.1 Larval Salivary Gland    51.7 Larval Trachea    32.7 Larval Carcass    28.475 Adult Head    33.2 Adult Eye    24.125 Adult Brain    72.9 Adult Thoracic-Abdominal Ganglion    49.3 Adult Crop    32.4 Adult Midgut    24.5 Adult Hindgut    35.1 Adult Malpighian Tubules    39.7 Adult Fat Body    28.3 Adult Salivary Gland    23.7 Adult Heart    25.925 Adult VirginFemale Spermatheca    26.8 Adult InseminatedFemale Spermatheca    33.7 Adult Ovary    120.7 Adult Testis    54.4 Adult Male Accessory Gland    30.5 Adult Carcass    36.6 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    60.45 Larval Midgut    34.7 Larval Hindgut    40.2 Larval Malpighian Tubules    68.5 Larval Fat Body    47.1 Larval Salivary Gland    51.7 Larval Trachea    32.7 Larval Carcass    28.475 Adult Head    33.2 Adult Eye    24.125 Adult Brain    72.9 Adult Thoracic-Abdominal Ganglion    49.3 Adult Crop    32.4 Adult Midgut    24.5 Adult Hindgut    35.1 Adult Malpighian Tubules    39.7 Adult Fat Body    28.3 Adult Salivary Gland    23.7 Adult Heart    25.925 Adult VirginFemale Spermatheca    26.8 Adult InseminatedFemale Spermatheca    33.7 Adult Ovary    120.7 Adult Testis    54.4 Adult Male Accessory Gland    30.5 Adult Carcass    36.6 Expression Level Scale  None   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    60.45 Larval Midgut    34.7 Larval Hindgut    40.2 Larval Malpighian Tubules    68.5 Larval Fat Body    47.1 Larval Salivary Gland    51.7 Larval Trachea    32.7 Larval Carcass    28.475 Adult Head    33.2 Adult Eye    24.125 Adult Brain    72.9 Adult Thoracic-Abdominal Ganglion    49.3 Adult Crop    32.4 Adult Midgut    24.5 Adult Hindgut    35.1 Adult Malpighian Tubules    39.7 Adult Fat Body    28.3 Adult Salivary Gland    23.7 Adult Heart    25.925 Adult VirginFemale Spermatheca    26.8 Adult InseminatedFemale Spermatheca    33.7 Adult Ovary    120.7 Adult Testis    54.4 Adult Male Accessory Gland    30.5 Adult Carcass    36.6 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    60.45 Larval Midgut    34.7 Larval Hindgut    40.2 Larval Malpighian Tubules    68.5 Larval Fat Body    47.1 Larval Salivary Gland    51.7 Larval Trachea    32.7 Larval Carcass    28.475 Adult Head    33.2 Adult Eye    24.125 Adult Brain    72.9 Adult Thoracic-Abdominal Ganglion    49.3 Adult Crop    32.4 Adult Midgut    24.5 Adult Hindgut    35.1 Adult Malpighian Tubules    39.7 Adult Fat Body    28.3 Adult Salivary Gland    23.7 Adult Heart    25.925 Adult VirginFemale Spermatheca    26.8 Adult InseminatedFemale Spermatheca    33.7 Adult Ovary    120.7 Adult Testis    54.4 Adult Male Accessory Gland    30.5 Adult Carcass    36.6 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    60.45 Larval Midgut    34.7 Larval Hindgut    40.2 Larval Malpighian Tubules    68.5 Larval Fat Body    47.1 Larval Salivary Gland    51.7 Larval Trachea    32.7 Larval Carcass    28.475 Adult Head    33.2 Adult Eye    24.125 Adult Brain    72.9 Adult Thoracic-Abdominal Ganglion    49.3 Adult Crop    32.4 Adult Midgut    24.5 Adult Hindgut    35.1 Adult Malpighian Tubules    39.7 Adult Fat Body    28.3 Adult Salivary Gland    23.7 Adult Heart    25.925 Adult VirginFemale Spermatheca    26.8 Adult InseminatedFemale Spermatheca    33.7 Adult Ovary    120.7 Adult Testis    54.4 Adult Male Accessory Gland    30.5 Adult Carcass    36.6 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    33.2   NA  Eye    24.125   NA  Brain    72.9   60.45  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    49.3   NA  Crop    32.4   34.7  Midgut    24.5   40.2  Hindgut    35.1   68.5  Malpighian Tubules    no informative data   47.1  Fat Body    no informative data   51.7  Salivary Gland    no informative data   NA  Heart    25.925   32.7  Trachea    NA   NA  VirginFemale Spermatheca    no informative data   NA  InseminatedFemale Spermatheca    33.7   NA  Ovary    120.7   NA  Testis    54.4   NA  Male Accessory Gland    no informative data   28.475  Carcass    36.6 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    20 central nervous system, larvae L3    17 central nervous system, pupae P8    12 head, virgin 1-day female    6 head, virgin 4-day female    10 head, virgin 20-day female    5 head, mated 1-day female    10 head, mated 4-day female    8 head, mated 20-day female    5 head, mated 1-day male    9 head, mated 4-day male    12 head, mated 20-day male    14 salivary gland, larvae L3 wandering    9 salivary gland, white prepupae    43 digestive system, larvae L3 wandering    13 digestive system, 1-day adult    6 digestive system, 4-day adult    10 digestive system, 20-day adult    6 fat body, larvae L3 wandering    4 fat body, white prepupae    6 fat body, pupae P8    19 carcass, larvae L3 wandering    12 carcass, 1-day adult    6 carcass, 4-day adult    8 carcass, 20-day adult    6 ovary, virgin 4-day female    31 ovary, mated 4-day female    42 testis, mated 4-day male    19 accessory gland, mated 4-day male    5 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    20 central nervous system, larvae L3    17 central nervous system, pupae P8    12 head, virgin 1-day female    6 head, virgin 4-day female    10 head, virgin 20-day female    5 head, mated 1-day female    10 head, mated 4-day female    8 head, mated 20-day female    5 head, mated 1-day male    9 head, mated 4-day male    12 head, mated 20-day male    14 salivary gland, larvae L3 wandering    9 salivary gland, white prepupae  (43) digestive system, larvae L3 wandering    13 digestive system, 1-day adult    6 digestive system, 4-day adult    10 digestive system, 20-day adult    6 fat body, larvae L3 wandering    4 fat body, white prepupae    6 fat body, pupae P8    19 carcass, larvae L3 wandering    12 carcass, 1-day adult    6 carcass, 4-day adult    8 carcass, 20-day adult    6 ovary, virgin 4-day female  (31) ovary, mated 4-day female  (42) testis, mated 4-day male    19 accessory gland, mated 4-day male    5 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    20 central nervous system, larvae L3    17 central nervous system, pupae P8    12 head, virgin 1-day female    6 head, virgin 4-day female    10 head, virgin 20-day female    5 head, mated 1-day female    10 head, mated 4-day female    8 head, mated 20-day female    5 head, mated 1-day male    9 head, mated 4-day male    12 head, mated 20-day male    14 salivary gland, larvae L3 wandering    9 salivary gland, white prepupae    43 digestive system, larvae L3 wandering    13 digestive system, 1-day adult    6 digestive system, 4-day adult    10 digestive system, 20-day adult    6 fat body, larvae L3 wandering    4 fat body, white prepupae    6 fat body, pupae P8    19 carcass, larvae L3 wandering    12 carcass, 1-day adult    6 carcass, 4-day adult    8 carcass, 20-day adult    6 ovary, virgin 4-day female    31 ovary, mated 4-day female    42 testis, mated 4-day male    19 accessory gland, mated 4-day male    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    20 central nervous system, larvae L3    17 central nervous system, pupae P8    12 head, virgin 1-day female    6 head, virgin 4-day female    10 head, virgin 20-day female    5 head, mated 1-day female    10 head, mated 4-day female    8 head, mated 20-day female    5 head, mated 1-day male    9 head, mated 4-day male    12 head, mated 20-day male    14 salivary gland, larvae L3 wandering    9 salivary gland, white prepupae    43 digestive system, larvae L3 wandering    13 digestive system, 1-day adult    6 digestive system, 4-day adult    10 digestive system, 20-day adult    6 fat body, larvae L3 wandering    4 fat body, white prepupae    6 fat body, pupae P8    19 carcass, larvae L3 wandering    12 carcass, 1-day adult    6 carcass, 4-day adult    8 carcass, 20-day adult    6 ovary, virgin 4-day female    31 ovary, mated 4-day female    42 testis, mated 4-day male    19 accessory gland, mated 4-day male    5 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    20 central nervous system, larvae L3    17 central nervous system, pupae P8    12 head, virgin 1-day female    6 head, virgin 4-day female    10 head, virgin 20-day female    5 head, mated 1-day female    10 head, mated 4-day female    8 head, mated 20-day female    5 head, mated 1-day male    9 head, mated 4-day male    12 head, mated 20-day male    14 salivary gland, larvae L3 wandering    9 salivary gland, white prepupae    43 digestive system, larvae L3 wandering    13 digestive system, 1-day adult    6 digestive system, 4-day adult    10 digestive system, 20-day adult    6 fat body, larvae L3 wandering    4 fat body, white prepupae    6 fat body, pupae P8    19 carcass, larvae L3 wandering    12 carcass, 1-day adult    6 carcass, 4-day adult    8 carcass, 20-day adult    6 ovary, virgin 4-day female    31 ovary, mated 4-day female    42 testis, mated 4-day male    19 accessory gland, mated 4-day male    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    20 central nervous system, larvae L3    17 central nervous system, pupae P8    12 head, virgin 1-day female    6 head, virgin 4-day female    10 head, virgin 20-day female    5 head, mated 1-day female    10 head, mated 4-day female    8 head, mated 20-day female    5 head, mated 1-day male    9 head, mated 4-day male    12 head, mated 20-day male    14 salivary gland, larvae L3 wandering    9 salivary gland, white prepupae  (43) digestive system, larvae L3 wandering    13 digestive system, 1-day adult    6 digestive system, 4-day adult    10 digestive system, 20-day adult    6 fat body, larvae L3 wandering    4 fat body, white prepupae    6 fat body, pupae P8    19 carcass, larvae L3 wandering    12 carcass, 1-day adult    6 carcass, 4-day adult    8 carcass, 20-day adult    6 ovary, virgin 4-day female  31 ovary, mated 4-day female  (42) testis, mated 4-day male    19 accessory gland, mated 4-day male    5 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    20 central nervous system, larvae L3    17 central nervous system, pupae P8    12 head, virgin 1-day female    6 head, virgin 4-day female    10 head, virgin 20-day female    5 head, mated 1-day female    10 head, mated 4-day female    8 head, mated 20-day female    5 head, mated 1-day male    9 head, mated 4-day male    12 head, mated 20-day male    14 salivary gland, larvae L3 wandering    9 salivary gland, white prepupae    43 digestive system, larvae L3 wandering    13 digestive system, 1-day adult    6 digestive system, 4-day adult    10 digestive system, 20-day adult    6 fat body, larvae L3 wandering    4 fat body, white prepupae    6 fat body, pupae P8    19 carcass, larvae L3 wandering    12 carcass, 1-day adult    6 carcass, 4-day adult    8 carcass, 20-day adult    6 ovary, virgin 4-day female    31 ovary, mated 4-day female    42 testis, mated 4-day male    19 accessory gland, mated 4-day male    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    20 central nervous system, larvae L3    17 central nervous system, pupae P8    12 head, virgin 1-day female    6 head, virgin 4-day female    10 head, virgin 20-day female    5 head, mated 1-day female    10 head, mated 4-day female    8 head, mated 20-day female    5 head, mated 1-day male    9 head, mated 4-day male    12 head, mated 20-day male    14 salivary gland, larvae L3 wandering    9 salivary gland, white prepupae    43 digestive system, larvae L3 wandering    13 digestive system, 1-day adult    6 digestive system, 4-day adult    10 digestive system, 20-day adult    6 fat body, larvae L3 wandering    4 fat body, white prepupae    6 fat body, pupae P8    19 carcass, larvae L3 wandering    12 carcass, 1-day adult    6 carcass, 4-day adult    8 carcass, 20-day adult    6 ovary, virgin 4-day female    31 ovary, mated 4-day female    42 testis, mated 4-day male    19 accessory gland, mated 4-day male    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of low expression. Peak expression observed at stages throughout embryogenesis, during late larval stages, at stages throughout the pupal period, in stages of adults of both sexes. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    15 embryo 02-04hr    7 embryo 04-06hr    9 embryo 06-08hr    10 embryo 08-10hr    9 embryo 10-12hr    10 embryo 12-14hr    7 embryo 14-16hr    5 embryo 16-18hr    4 embryo 18-20hr    5 embryo 20-22hr    4 embryo 22-24hr    5 larva L1    5 larva L2    4 larva L3 12hr old    3 larva L3 puffstage 1-2    4 larva L3 puffstage 3-6    6 larva L3 puffstage 7-9    8 white prepupae new    8 white prepupae 12hr    14 white prepupae 24hr    10 pupae 2d postWPP    9 pupae 3d postWPP    5 pupae 4d postWPP    4 adult male 01day    5 adult male 05day    6 adult male 30day    6 adult female 01day    6 adult female 05day    12 adult female 30day    12 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    15 embryo 02-04hr    7 embryo 04-06hr    9 embryo 06-08hr    10 embryo 08-10hr    9 embryo 10-12hr    10 embryo 12-14hr    7 embryo 14-16hr    5 embryo 16-18hr    4 embryo 18-20hr    5 embryo 20-22hr    4 embryo 22-24hr    5 larva L1    5 larva L2    4 larva L3 12hr old    3 larva L3 puffstage 1-2    4 larva L3 puffstage 3-6    6 larva L3 puffstage 7-9    8 white prepupae new    8 white prepupae 12hr    14 white prepupae 24hr    10 pupae 2d postWPP    9 pupae 3d postWPP    5 pupae 4d postWPP    4 adult male 01day    5 adult male 05day    6 adult male 30day    6 adult female 01day    6 adult female 05day    12 adult female 30day    12 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    15 embryo 02-04hr    7 embryo 04-06hr    9 embryo 06-08hr    10 embryo 08-10hr    9 embryo 10-12hr    10 embryo 12-14hr    7 embryo 14-16hr    5 embryo 16-18hr    4 embryo 18-20hr    5 embryo 20-22hr    4 embryo 22-24hr    5 larva L1    5 larva L2    4 larva L3 12hr old    3 larva L3 puffstage 1-2    4 larva L3 puffstage 3-6    6 larva L3 puffstage 7-9    8 white prepupae new    8 white prepupae 12hr    14 white prepupae 24hr    10 pupae 2d postWPP    9 pupae 3d postWPP    5 pupae 4d postWPP    4 adult male 01day    5 adult male 05day    6 adult male 30day    6 adult female 01day    6 adult female 05day    12 adult female 30day    12 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    15 embryo 02-04hr    7 embryo 04-06hr    9 embryo 06-08hr    10 embryo 08-10hr    9 embryo 10-12hr    10 embryo 12-14hr    7 embryo 14-16hr    5 embryo 16-18hr    4 embryo 18-20hr    5 embryo 20-22hr    4 embryo 22-24hr    5 larva L1    5 larva L2    4 larva L3 12hr old    3 larva L3 puffstage 1-2    4 larva L3 puffstage 3-6    6 larva L3 puffstage 7-9    8 white prepupae new    8 white prepupae 12hr    14 white prepupae 24hr    10 pupae 2d postWPP    9 pupae 3d postWPP    5 pupae 4d postWPP    4 adult male 01day    5 adult male 05day    6 adult male 30day    6 adult female 01day    6 adult female 05day    12 adult female 30day    12 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    15 embryo 02-04hr    7 embryo 04-06hr    9 embryo 06-08hr    10 embryo 08-10hr    9 embryo 10-12hr    10 embryo 12-14hr    7 embryo 14-16hr    5 embryo 16-18hr    4 embryo 18-20hr    5 embryo 20-22hr    4 embryo 22-24hr    5 larva L1    5 larva L2    4 larva L3 12hr old    3 larva L3 puffstage 1-2    4 larva L3 puffstage 3-6    6 larva L3 puffstage 7-9    8 white prepupae new    8 white prepupae 12hr    14 white prepupae 24hr    10 pupae 2d postWPP    9 pupae 3d postWPP    5 pupae 4d postWPP    4 adult male 01day    5 adult male 05day    6 adult male 30day    6 adult female 01day    6 adult female 05day    12 adult female 30day    12 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    15 embryo 02-04hr    7 embryo 04-06hr    9 embryo 06-08hr    10 embryo 08-10hr    9 embryo 10-12hr    10 embryo 12-14hr    7 embryo 14-16hr    5 embryo 16-18hr    4 embryo 18-20hr    5 embryo 20-22hr    4 embryo 22-24hr    5 larva L1    5 larva L2    4 larva L3 12hr old    3 larva L3 puffstage 1-2    4 larva L3 puffstage 3-6    6 larva L3 puffstage 7-9    8 white prepupae new    8 white prepupae 12hr    14 white prepupae 24hr    10 pupae 2d postWPP    9 pupae 3d postWPP    5 pupae 4d postWPP    4 adult male 01day    5 adult male 05day    6 adult male 30day    6 adult female 01day    6 adult female 05day    12 adult female 30day    12 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    15 embryo 02-04hr    7 embryo 04-06hr    9 embryo 06-08hr    10 embryo 08-10hr    9 embryo 10-12hr    10 embryo 12-14hr    7 embryo 14-16hr    5 embryo 16-18hr    4 embryo 18-20hr    5 embryo 20-22hr    4 embryo 22-24hr    5 larva L1    5 larva L2    4 larva L3 12hr old    3 larva L3 puffstage 1-2    4 larva L3 puffstage 3-6    6 larva L3 puffstage 7-9    8 white prepupae new    8 white prepupae 12hr    14 white prepupae 24hr    10 pupae 2d postWPP    9 pupae 3d postWPP    5 pupae 4d postWPP    4 adult male 01day    5 adult male 05day    6 adult male 30day    6 adult female 01day    6 adult female 05day    12 adult female 30day    12 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    15 embryo 02-04hr    7 embryo 04-06hr    9 embryo 06-08hr    10 embryo 08-10hr    9 embryo 10-12hr    10 embryo 12-14hr    7 embryo 14-16hr    5 embryo 16-18hr    4 embryo 18-20hr    5 embryo 20-22hr    4 embryo 22-24hr    5 larva L1    5 larva L2    4 larva L3 12hr old    3 larva L3 puffstage 1-2    4 larva L3 puffstage 3-6    6 larva L3 puffstage 7-9    8 white prepupae new    8 white prepupae 12hr    14 white prepupae 24hr    10 pupae 2d postWPP    9 pupae 3d postWPP    5 pupae 4d postWPP    4 adult male 01day    5 adult male 05day    6 adult male 30day    6 adult female 01day    6 adult female 05day    12 adult female 30day    12 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    16 Schneider line 2 Sg4    11 embryonic 1182-4H    15 embryonic GM2    10 embryonic Kc167    14 embryonic S1    23 embryonic S3    8 leg disc CME L1    21 wing disc CME-W2    8 wing disc ML-DmD8    9 wing disc ML-DmD9    17 wing disc ML-DmD16-c3    22 wing disc ML-DmD21    31 wing disc ML-DmD32    14 haltere disc ML-DmD17-c3    14 eye-antennal disc ML-DmD11    11 antennal disc ML-DmD20-c5    16 mixed discs ML-DmD4-c1    14 CNS ML-DmBG1-c1    20 CNS ML-DmBG2-c2    13 tumorous blood cells mbn2    6 ovary fGS/OSS    55 ovary OSC    29 ovary OSS    26 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    16 Schneider line 2 Sg4    11 embryonic 1182-4H    15 embryonic GM2    10 embryonic Kc167    14 embryonic S1    23 embryonic S3    8 leg disc CME L1    21 wing disc CME-W2    8 wing disc ML-DmD8    9 wing disc ML-DmD9    17 wing disc ML-DmD16-c3    22 wing disc ML-DmD21  (31) wing disc ML-DmD32    14 haltere disc ML-DmD17-c3    14 eye-antennal disc ML-DmD11    11 antennal disc ML-DmD20-c5    16 mixed discs ML-DmD4-c1    14 CNS ML-DmBG1-c1    20 CNS ML-DmBG2-c2    13 tumorous blood cells mbn2    6 ovary fGS/OSS  (55) ovary OSC  (29) ovary OSS  26 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    16 Schneider line 2 Sg4    11 embryonic 1182-4H    15 embryonic GM2    10 embryonic Kc167    14 embryonic S1    23 embryonic S3    8 leg disc CME L1    21 wing disc CME-W2    8 wing disc ML-DmD8    9 wing disc ML-DmD9    17 wing disc ML-DmD16-c3    22 wing disc ML-DmD21    31 wing disc ML-DmD32    14 haltere disc ML-DmD17-c3    14 eye-antennal disc ML-DmD11    11 antennal disc ML-DmD20-c5    16 mixed discs ML-DmD4-c1    14 CNS ML-DmBG1-c1    20 CNS ML-DmBG2-c2    13 tumorous blood cells mbn2    6 ovary fGS/OSS    55 ovary OSC    29 ovary OSS    26 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    16 Schneider line 2 Sg4    11 embryonic 1182-4H    15 embryonic GM2    10 embryonic Kc167    14 embryonic S1    23 embryonic S3    8 leg disc CME L1    21 wing disc CME-W2    8 wing disc ML-DmD8    9 wing disc ML-DmD9    17 wing disc ML-DmD16-c3    22 wing disc ML-DmD21    31 wing disc ML-DmD32    14 haltere disc ML-DmD17-c3    14 eye-antennal disc ML-DmD11    11 antennal disc ML-DmD20-c5    16 mixed discs ML-DmD4-c1    14 CNS ML-DmBG1-c1    20 CNS ML-DmBG2-c2    13 tumorous blood cells mbn2    6 ovary fGS/OSS    55 ovary OSC    29 ovary OSS    26 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    16 Schneider line 2 Sg4    11 embryonic 1182-4H    15 embryonic GM2    10 embryonic Kc167    14 embryonic S1    23 embryonic S3    8 leg disc CME L1    21 wing disc CME-W2    8 wing disc ML-DmD8    9 wing disc ML-DmD9    17 wing disc ML-DmD16-c3    22 wing disc ML-DmD21    31 wing disc ML-DmD32    14 haltere disc ML-DmD17-c3    14 eye-antennal disc ML-DmD11    11 antennal disc ML-DmD20-c5    16 mixed discs ML-DmD4-c1    14 CNS ML-DmBG1-c1    20 CNS ML-DmBG2-c2    13 tumorous blood cells mbn2    6 ovary fGS/OSS    55 ovary OSC    29 ovary OSS    26 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    16 Schneider line 2 Sg4    11 embryonic 1182-4H    15 embryonic GM2    10 embryonic Kc167    14 embryonic S1    23 embryonic S3    8 leg disc CME L1    21 wing disc CME-W2    8 wing disc ML-DmD8    9 wing disc ML-DmD9    17 wing disc ML-DmD16-c3    22 wing disc ML-DmD21  31 wing disc ML-DmD32    14 haltere disc ML-DmD17-c3    14 eye-antennal disc ML-DmD11    11 antennal disc ML-DmD20-c5    16 mixed discs ML-DmD4-c1    14 CNS ML-DmBG1-c1    20 CNS ML-DmBG2-c2    13 tumorous blood cells mbn2    6 ovary fGS/OSS  (55) ovary OSC  29 ovary OSS  26 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    16 Schneider line 2 Sg4    11 embryonic 1182-4H    15 embryonic GM2    10 embryonic Kc167    14 embryonic S1    23 embryonic S3    8 leg disc CME L1    21 wing disc CME-W2    8 wing disc ML-DmD8    9 wing disc ML-DmD9    17 wing disc ML-DmD16-c3    22 wing disc ML-DmD21    31 wing disc ML-DmD32    14 haltere disc ML-DmD17-c3    14 eye-antennal disc ML-DmD11    11 antennal disc ML-DmD20-c5    16 mixed discs ML-DmD4-c1    14 CNS ML-DmBG1-c1    20 CNS ML-DmBG2-c2    13 tumorous blood cells mbn2    6 ovary fGS/OSS    55 ovary OSC    29 ovary OSS    26 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    16 Schneider line 2 Sg4    11 embryonic 1182-4H    15 embryonic GM2    10 embryonic Kc167    14 embryonic S1    23 embryonic S3    8 leg disc CME L1    21 wing disc CME-W2    8 wing disc ML-DmD8    9 wing disc ML-DmD9    17 wing disc ML-DmD16-c3    22 wing disc ML-DmD21    31 wing disc ML-DmD32    14 haltere disc ML-DmD17-c3    14 eye-antennal disc ML-DmD11    11 antennal disc ML-DmD20-c5    16 mixed discs ML-DmD4-c1    14 CNS ML-DmBG1-c1    20 CNS ML-DmBG2-c2    13 tumorous blood cells mbn2    6 ovary fGS/OSS    55 ovary OSC    29 ovary OSS    26 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    23 cold shock, 4-day adult    14 heat shock, 4-day adult    12 Cadmium 50 mM 6 hrs, larvae L3    8 Cadmium 50 mM 12 hrs, larvae L3    9 Cadmium 50 mM 48 hrs, 4-day adult    15 Cadmium 100 mM 48 hrs, 4-day adult    26 Copper 0.5 mM 12 hrs, larvae L3    15 Copper 15 mM 48 hrs, 4-day adult    20 Zinc 5 mM 12 hrs, larvae L3    11 Zinc 4.5 mM 48 hrs, 4-day adult    14 Ethanol 2.5% 3 hrs, larvae L3    23 Ethanol 5% 3 hrs, larvae L3    7 Ethanol 10% 3 hrs, larvae L3    5 Caffeine 1.5 mg/ml 4 hrs, larvae L3    7 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    30 Caffeine 25 mg/ml 48 hrs, 4-day adult    20 Paraquat 5 mM 48 hrs, 4-day adult    30 Paraquat 10 mM 48 hrs, 4-day adult    15 Rotenone 2 μg 12 hrs, larvae L3    6 Rotenone 8 μg 12 hrs, larvae L3    7 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    23 cold shock, 4-day adult    14 heat shock, 4-day adult    12 Cadmium 50 mM 6 hrs, larvae L3    8 Cadmium 50 mM 12 hrs, larvae L3    9 Cadmium 50 mM 48 hrs, 4-day adult    15 Cadmium 100 mM 48 hrs, 4-day adult  26 Copper 0.5 mM 12 hrs, larvae L3    15 Copper 15 mM 48 hrs, 4-day adult    20 Zinc 5 mM 12 hrs, larvae L3    11 Zinc 4.5 mM 48 hrs, 4-day adult    14 Ethanol 2.5% 3 hrs, larvae L3    23 Ethanol 5% 3 hrs, larvae L3    7 Ethanol 10% 3 hrs, larvae L3    5 Caffeine 1.5 mg/ml 4 hrs, larvae L3    7 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (30) Caffeine 25 mg/ml 48 hrs, 4-day adult    20 Paraquat 5 mM 48 hrs, 4-day adult  (30) Paraquat 10 mM 48 hrs, 4-day adult    15 Rotenone 2 μg 12 hrs, larvae L3    6 Rotenone 8 μg 12 hrs, larvae L3    7 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    23 cold shock, 4-day adult    14 heat shock, 4-day adult    12 Cadmium 50 mM 6 hrs, larvae L3    8 Cadmium 50 mM 12 hrs, larvae L3    9 Cadmium 50 mM 48 hrs, 4-day adult    15 Cadmium 100 mM 48 hrs, 4-day adult    26 Copper 0.5 mM 12 hrs, larvae L3    15 Copper 15 mM 48 hrs, 4-day adult    20 Zinc 5 mM 12 hrs, larvae L3    11 Zinc 4.5 mM 48 hrs, 4-day adult    14 Ethanol 2.5% 3 hrs, larvae L3    23 Ethanol 5% 3 hrs, larvae L3    7 Ethanol 10% 3 hrs, larvae L3    5 Caffeine 1.5 mg/ml 4 hrs, larvae L3    7 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    30 Caffeine 25 mg/ml 48 hrs, 4-day adult    20 Paraquat 5 mM 48 hrs, 4-day adult    30 Paraquat 10 mM 48 hrs, 4-day adult    15 Rotenone 2 μg 12 hrs, larvae L3    6 Rotenone 8 μg 12 hrs, larvae L3    7 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    23 cold shock, 4-day adult    14 heat shock, 4-day adult    12 Cadmium 50 mM 6 hrs, larvae L3    8 Cadmium 50 mM 12 hrs, larvae L3    9 Cadmium 50 mM 48 hrs, 4-day adult    15 Cadmium 100 mM 48 hrs, 4-day adult    26 Copper 0.5 mM 12 hrs, larvae L3    15 Copper 15 mM 48 hrs, 4-day adult    20 Zinc 5 mM 12 hrs, larvae L3    11 Zinc 4.5 mM 48 hrs, 4-day adult    14 Ethanol 2.5% 3 hrs, larvae L3    23 Ethanol 5% 3 hrs, larvae L3    7 Ethanol 10% 3 hrs, larvae L3    5 Caffeine 1.5 mg/ml 4 hrs, larvae L3    7 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    30 Caffeine 25 mg/ml 48 hrs, 4-day adult    20 Paraquat 5 mM 48 hrs, 4-day adult    30 Paraquat 10 mM 48 hrs, 4-day adult    15 Rotenone 2 μg 12 hrs, larvae L3    6 Rotenone 8 μg 12 hrs, larvae L3    7 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    23 cold shock, 4-day adult    14 heat shock, 4-day adult    12 Cadmium 50 mM 6 hrs, larvae L3    8 Cadmium 50 mM 12 hrs, larvae L3    9 Cadmium 50 mM 48 hrs, 4-day adult    15 Cadmium 100 mM 48 hrs, 4-day adult    26 Copper 0.5 mM 12 hrs, larvae L3    15 Copper 15 mM 48 hrs, 4-day adult    20 Zinc 5 mM 12 hrs, larvae L3    11 Zinc 4.5 mM 48 hrs, 4-day adult    14 Ethanol 2.5% 3 hrs, larvae L3    23 Ethanol 5% 3 hrs, larvae L3    7 Ethanol 10% 3 hrs, larvae L3    5 Caffeine 1.5 mg/ml 4 hrs, larvae L3    7 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    30 Caffeine 25 mg/ml 48 hrs, 4-day adult    20 Paraquat 5 mM 48 hrs, 4-day adult    30 Paraquat 10 mM 48 hrs, 4-day adult    15 Rotenone 2 μg 12 hrs, larvae L3    6 Rotenone 8 μg 12 hrs, larvae L3    7 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    23 cold shock, 4-day adult    14 heat shock, 4-day adult    12 Cadmium 50 mM 6 hrs, larvae L3    8 Cadmium 50 mM 12 hrs, larvae L3    9 Cadmium 50 mM 48 hrs, 4-day adult    15 Cadmium 100 mM 48 hrs, 4-day adult  26 Copper 0.5 mM 12 hrs, larvae L3    15 Copper 15 mM 48 hrs, 4-day adult    20 Zinc 5 mM 12 hrs, larvae L3    11 Zinc 4.5 mM 48 hrs, 4-day adult    14 Ethanol 2.5% 3 hrs, larvae L3    23 Ethanol 5% 3 hrs, larvae L3    7 Ethanol 10% 3 hrs, larvae L3    5 Caffeine 1.5 mg/ml 4 hrs, larvae L3    7 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  30 Caffeine 25 mg/ml 48 hrs, 4-day adult    20 Paraquat 5 mM 48 hrs, 4-day adult  30 Paraquat 10 mM 48 hrs, 4-day adult    15 Rotenone 2 μg 12 hrs, larvae L3    6 Rotenone 8 μg 12 hrs, larvae L3    7 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    23 cold shock, 4-day adult    14 heat shock, 4-day adult    12 Cadmium 50 mM 6 hrs, larvae L3    8 Cadmium 50 mM 12 hrs, larvae L3    9 Cadmium 50 mM 48 hrs, 4-day adult    15 Cadmium 100 mM 48 hrs, 4-day adult    26 Copper 0.5 mM 12 hrs, larvae L3    15 Copper 15 mM 48 hrs, 4-day adult    20 Zinc 5 mM 12 hrs, larvae L3    11 Zinc 4.5 mM 48 hrs, 4-day adult    14 Ethanol 2.5% 3 hrs, larvae L3    23 Ethanol 5% 3 hrs, larvae L3    7 Ethanol 10% 3 hrs, larvae L3    5 Caffeine 1.5 mg/ml 4 hrs, larvae L3    7 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    30 Caffeine 25 mg/ml 48 hrs, 4-day adult    20 Paraquat 5 mM 48 hrs, 4-day adult    30 Paraquat 10 mM 48 hrs, 4-day adult    15 Rotenone 2 μg 12 hrs, larvae L3    6 Rotenone 8 μg 12 hrs, larvae L3    7 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    23 cold shock, 4-day adult    14 heat shock, 4-day adult    12 Cadmium 50 mM 6 hrs, larvae L3    8 Cadmium 50 mM 12 hrs, larvae L3    9 Cadmium 50 mM 48 hrs, 4-day adult    15 Cadmium 100 mM 48 hrs, 4-day adult    26 Copper 0.5 mM 12 hrs, larvae L3    15 Copper 15 mM 48 hrs, 4-day adult    20 Zinc 5 mM 12 hrs, larvae L3    11 Zinc 4.5 mM 48 hrs, 4-day adult    14 Ethanol 2.5% 3 hrs, larvae L3    23 Ethanol 5% 3 hrs, larvae L3    7 Ethanol 10% 3 hrs, larvae L3    5 Caffeine 1.5 mg/ml 4 hrs, larvae L3    7 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    30 Caffeine 25 mg/ml 48 hrs, 4-day adult    20 Paraquat 5 mM 48 hrs, 4-day adult    30 Paraquat 10 mM 48 hrs, 4-day adult    15 Rotenone 2 μg 12 hrs, larvae L3    6 Rotenone 8 μg 12 hrs, larvae L3    7 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_06 mE1_20_mRNA_expression_cluster_05
External Data & Images
Linkouts	BDGP expression data • RE01888 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0038128 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG15889-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable, with Scer\GAL4pnr-MD237 RavusGD8775 Other Phenotypes Allele non-enhancer of variegation, with In(1)wm4h Ravushs.T:Ivir\HA1 non-enhancer of variegation, with In(2)Heidi-P{Winkelried}D Ravushs.T:Ivir\HA1 non-enhancer of variegation, with In(2R)bwVDe2 Ravushs.T:Ivir\HA1 non-enhancer of variegation, with Tp(3;Y)BL2 Ravushs.T:Ivir\HA1 non-suppressor of variegation, with In(1)wm4h Ravushs.T:Ivir\HA1 non-suppressor of variegation, with In(2)Heidi-P{Winkelried}D Ravushs.T:Ivir\HA1 non-suppressor of variegation, with In(2R)bwVDe2 Ravushs.T:Ivir\HA1 non-suppressor of variegation, with Tp(3;Y)BL2 Ravushs.T:Ivir\HA1 Phenotype manifest in Allele
Classical Alleles ( 1 )
For All Classical Alleles Show
Allele of Ravus Class Mutagen Stocks Known lesion RavusHP35251 1 --
Alleles Carried on Transgenic Constructs ( 3 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Ravus Class Mutagen Stocks Known lesion RavusGD8775 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes RavusJF01303 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Ravushs.T:Ivir\HA1 in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3R)Exel8158 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data heat-shock construct P{hs-Ravus.D} NA UAS construct P{GD8775} NA P{TRiP.JF01303} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EPg}RavusHP35251 NA
Gene Ontology: Function, Process & Cellular Component ( 2 unique terms )
Terms Based on Experimental Evidence ( 1 term )
Molecular Function ( 0 terms)
Biological Process ( 0 terms)
Cellular Component
CV term Evidence References
colocalizes_with nuclear chromatin inferred from direct assay (Delattre et al., 2002)
Terms Based on Predictions or Assertions ( 1 term )
Molecular Function
CV term Evidence References
DNA binding inferred from electronic annotation with InterPro:IPR004210 (FlyBase Curators et al., 2004-)
Biological Process ( 0 terms)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Ravus allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 66710 DroID - A comprehensive database of gene and protein interactions. • FBgn0038128 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 41626
Orthologs
OrthoDB Orthologs (13) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG612MRM Dipteran inclusive ortholog search No orthologs identified Insect inclusive ortholog search EOG6QRG0X Arthropod inclusive ortholog search No orthologs identified Metazoa inclusive ortholog search No orthologs identified
Orthologs in Drosophila Species (EOG612MRM)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\Ravus     Drosophila simulans   Dsim\GD20514 Y   Drosophila sechellia   Dsec\GM25955 Y   Drosophila erecta   Dere\GG17069 Y   Drosophila yakuba   Dyak\GE24459 Y   Drosophila ananassae   Dana\GF17398 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA14007 Y   Drosophila persimilis   Dper\GL23134 Y   Drosophila willistoni   Dwil\GK22771 Y   Drosophila virilis   Dvir\GJ10788 Y   Drosophila mojavensis   Dmoj\GI24218 Y   Drosophila grimshawi   Dgri\GH19183 Y
Orthologs in non-Drosophila Dipterans (None identified)
No non-Drosophilid orthologies identified
Orthologs in non-Dipteran Insects (EOG6QRG0X)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Tribolium castaneum Red flour beetle  Tcas\TC009048
Orthologs in non-Insect Arthropods (None identified)
No non-Insect Arthropod orthologies identified
Orthologs in non-Arthropod Metazoa (None identified)
No non-Arthropod Metazoa orthologies identified
Human Orthologs (0)
Gene OMIM HGNC
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD20514 Drosophila sechellia Dsec\GM25955 Drosophila erecta Dere\GG17069 Drosophila yakuba Dyak\GE24459 Drosophila ananassae Dana\GF17398 Drosophila pseudoobscura pseudoobscura Dpse\GA14007 Drosophila persimilis Dper\GL23134 Drosophila willistoni Dwil\GK22771 Drosophila virilis Dvir\GJ10788 Drosophila mojavensis Dmoj\GI24218 Drosophila grimshawi Dgri\GH19183
Stocks & Reagents
Stocks Listed in FlyBase ( 4 )
Bloomington	22119 w1118; P{EPg}RavusHP35251 31345 y1 v1; P{TRiP.JF01303}attP2
VDRC	v32457 w1118 P{GD8775}v32457 v32455 w1118; P{GD8775}v32455
Genomic Clones ( 1 )
	BACR05K08 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 14 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	RE01888
Other clones	FI14740
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	LP21737 RH46875 SD17001
Other clones	106381 bs08b04 CK01.6C.H2 EK009546 EK232010 RP003326896 RP003558109 RP003577941 RP003677195
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0038128 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 41626
Antibody Information
Other Information
Discoverer
Etymology
	The gene is named "Ravus", as it is homologous to, and a close neighbour of "Su(var)3-7", but is transcribed in the other orientation. (Delattre et al., 2002)
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: Ravus CG15889 (Delattre et al., 2002)
Source for database merge of
Additional comments
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_169498 RefSeq (Proteins) • NP_731779 DDBJ / EMBL / GenBank • AAF54917 AAM51980 AI945024 AY121653 BI162617 BI162618 Entrez Gene - A searchable database of RefSeq genes. • 41626 UniProtKB/TrEMBL • Q8MRD3 Q9VFX8
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • BESS motif (IPR004210) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • RE01888
Linkouts
	BioGRID - A database of protein and genetic interactions • 66710 DroID - A comprehensive database of gene and protein interactions. • FBgn0038128 DRSC - Results from RNAi screens. • FBgn0038128 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0038128 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG15889-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0038128 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 41626 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 41626 modMine - Data generated by the modENCODE project. • FBgn0038128
Synonyms & Secondary IDs ( 2 )
Reported As
Symbol Synonym	CG15889 (Giot et al., 2003, Ni et al., 2008) Ravus (Bayes and Malik, 2007)
Name Synonym	Ravus
Secondary FlyBase IDs
References ( 17 )
Research paper	Ni et al., 2008, Nat. Methods 5(1): 49--51 Vector and parameters for targeted transgenic RNA interference in Drosophila melanogaster. [FBrf0200406] Delattre et al., 2002, Int. J. Dev. Biol. 46(1 Spec No): 167--171 A new gene in Drosophila melanogaster, Ravus, the phantom of the modifier of position-effect variegation Su(var)3-7. [FBrf0147087]
Supplementary material	Graveley et al., 2011, Nature 471(7339): Supplementary Table 33. Fuzzy Cluster Members. [FBrf0213980] The modENCODE Consortium, 2010, Science 330(6012): DataS14: Gene co-expression clusters. [FBrf0213979] Mummery-Widmer et al., 2009, Nature 458(7241): Supplementary Table 2 - Genome-wide bristle screen results. [FBrf0214518] Giot et al., 2003, Science 302(5651): Tables S1 to S7. [FBrf0166452]
Personal communication to FlyBase	Matthews, 2008.4.15, DP and HP P-element insertions submitted to the Bloomington Drosophila Stock Center. DP and HP P-element insertions submitted to the Bloomington Drosophila Stock Center. [FBrf0204789] Dickson et al., 2007.7.18, RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0200327] FlyBase Curators et al., 2004-, Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. [FBrf0174215] Ryder, 2004.4.26, Exelixis CG deletion data. Exelixis CG deletion data. [FBrf0184335] Oliver, 2001.8.16, Genome Res.: File from B. Oliver containing information on ESTs expressed in the Drosophila testis, described in Andrews et al., 2000, Genome Res. 10(12): 2030-2043 (FBrf0132348). [FBrf0137492] BDGP Project Members, 2000-, Berkeley Drosophila Genome Project. (Computer file) Berkeley Drosophila Genome Project. (Computer file) [FBrf0125078]
Abstract	Bayes and Malik, 2007, A. Dros. Res. Conf. 48: 662B Shifting sands of heterochromatin? A rapidly evolving heterochromatin protein, Su(var)3-7. [FBrf0198211]
FlyBase analysis	FlyBase, 1992-, FlyBase curation. FlyBase curation. [FBrf0105495]
Website	Fisher et al., 2012, BDGP insitu homepage BDGP insitu homepage [FBrf0219073]
Curated genome annotation	FamiliarityBreedsContempt, 1999.11, [Automatic annotations performed at the Celera Jamboreee.] [Automatic annotations performed at the Celera Jamboreee.] [FBrf0126705]