Please see the JBrowse view of Dmel\Osi22 for information on other features
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AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Gene model reviewed during 5.47
There is only one protein coding transcript and one polypeptide associated with this gene
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Osi22 using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
JBrowse - Visual display of RNA-Seq signals
View Dmel\Osi22 in JBrowse3-53
3-50.8
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
The Tpl region is both triplo-lethal and haplo-lethal and neither point nor insertional mutations of Tpl have been isolated despite extensive mutagenesis analysis. This raises the possibility that Tpl consists of a cluster of genes with at least partial redundancy. Osi22 is a member of the "Osiris" family of genes (which contains 23 members). 20 of the "Osiris" genes are located in a cluster within the Tpl region of the genome at 83D-83E (the remaining 3 members - Osi21, Osi22 and Osi23 - are located at three different sites in the genome. None of these 3 loci are triplo-lethal or are located within a haplo-insufficient region). The "Osiris" gene family is also present in the A.gambiae genome and shows remarkable synteny and sequence conservation with the D.melanogaster cluster. There appears to have been selection on the "Osiris" family both for expression level and function. It is suggested that the "Osiris" gene family cluster corresponds to Tpl.
Source for identity of: Osi22 CG8644
The gene is named "Osiris" since it belongs to a family of related proteins, 20 of which are in a cluster located in the Tpl region, and the "Isis" locus partially rescues the effect of trisomy for this region.
