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Gene Dmel\CG9588

General Information
Symbol	Dmel\CG9588	Species	D. melanogaster
Name		Annotation symbol	CG9588
Feature type	protein_coding_gene	FlyBase ID	FBgn0038166
Gene Model Status	Current	Stock availability	5 publicly available
Genomic Location
Chromosome (arm)	3R	Recombination map
Cytogenetic map	87F7-87F7	Sequence location	3R:9,500,814..9,502,398 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	This gene is referred to in FlyBase by the symbol Dmel\CG9588 (FBgn0038166). It is a protein_coding_gene from Drosophila melanogaster. Its molecular function is unknown. There is experimental evidence that it is involved in the biological process: response to DNA damage stimulus. 4 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: PDZ/DHR/GLGF. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed during early pupal stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval central nervous system, adult crop, adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval salivary gland, larval trachea, adult female reproductive system, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1629777_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of CG9588. Gene sequence location is 3R:9500814..9502398.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2011_10
FB2012_01	Sequence features HFA16504 BKN23089
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 87F7-87F7   Limits computationally determined from genome sequence between P{lacW}B52s2249&P{lacW}flflL4179 and P{PZ}flfl01949
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\CG9588 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) CG9588-RA FBtr0082849  NM_142044   1221   220
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein CG9588-PA   FBpp0082314   23.9   220   5.32     NP_650301   AAF54971
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • PDZ/DHR/GLGF (IPR001478)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA140946   AA736076   AE014297 AAF54971   AY071064 AAL48686   BF495826   BI230542   BI566318   BI586239   BI587737   BI591308   BI591328   BI615262   BI635219   CO181956   EC090488   EV598336   EV600591   FD586249   FD586331   FD586357   FD586382   FD586606   FD587001   FD587515   GH738879   GH762356   GH763502   GH764268   GH767871   GH779458   GH779509   GH779823   GO254468   GO254532
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9VFS8
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0038166    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0038166 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed during early pupal stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0038166 expression level Developmental Stage   Expression Level embryo 00-02hr    2649 embryo 02-04hr    1000 embryo 04-06hr    2982 embryo 06-08hr    3481 embryo 08-10hr    2653 embryo 10-12hr    2620 embryo 12-14hr    1434 embryo 14-16hr    1276 embryo 16-18hr    1021 embryo 18-20hr    928 embryo 20-22hr    837 embryo 22-24hr    775 larva L1    1101 larva L2    1200 larva L3 12hr old    1376 larva L3 puffstage 1-2    2230 larva L3 puffstage 3-6    3295 larva L3 puffstage 7-9    3754 white prepupae new    4119 white prepupae 12hr    2385 white prepupae 24hr    2499 pupae 2d postWPP    1796 pupae 3d postWPP    1048 pupae 4d postWPP    1421 adult male 01day    1510 adult male 05day    1765 adult male 30day    1748 adult female 01day    1995 adult female 05day    2302 adult female 30day    2380 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (2649) embryo 02-04hr  (1000) embryo 04-06hr  (2982) embryo 06-08hr  (3481) embryo 08-10hr  (2653) embryo 10-12hr  (2620) embryo 12-14hr  (1434) embryo 14-16hr  (1276) embryo 16-18hr  (1021) embryo 18-20hr  (928) embryo 20-22hr  (837) embryo 22-24hr  (775) larva L1  (1101) larva L2  (1200) larva L3 12hr old  (1376) larva L3 puffstage 1-2  (2230) larva L3 puffstage 3-6  (3295) larva L3 puffstage 7-9  (3754) white prepupae new  (4119) white prepupae 12hr  (2385) white prepupae 24hr  (2499) pupae 2d postWPP  (1796) pupae 3d postWPP  (1048) pupae 4d postWPP  (1421) adult male 01day  (1510) adult male 05day  (1765) adult male 30day  (1748) adult female 01day  (1995) adult female 05day  (2302) adult female 30day  (2380) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (2649) embryo 02-04hr    1000 embryo 04-06hr  (2982) embryo 06-08hr  (3481) embryo 08-10hr  (2653) embryo 10-12hr  (2620) embryo 12-14hr  1434 embryo 14-16hr    1276 embryo 16-18hr    1021 embryo 18-20hr    928 embryo 20-22hr    837 embryo 22-24hr    775 larva L1    1101 larva L2    1200 larva L3 12hr old    1376 larva L3 puffstage 1-2  (2230) larva L3 puffstage 3-6  (3295) larva L3 puffstage 7-9  (3754) white prepupae new  (4119) white prepupae 12hr  (2385) white prepupae 24hr  (2499) pupae 2d postWPP  (1796) pupae 3d postWPP    1048 pupae 4d postWPP  1421 adult male 01day  (1510) adult male 05day  (1765) adult male 30day  (1748) adult female 01day  (1995) adult female 05day  (2302) adult female 30day  (2380) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    2649 embryo 02-04hr    1000 embryo 04-06hr    2982 embryo 06-08hr    3481 embryo 08-10hr    2653 embryo 10-12hr    2620 embryo 12-14hr    1434 embryo 14-16hr    1276 embryo 16-18hr    1021 embryo 18-20hr    928 embryo 20-22hr    837 embryo 22-24hr    775 larva L1    1101 larva L2    1200 larva L3 12hr old    1376 larva L3 puffstage 1-2    2230 larva L3 puffstage 3-6    3295 larva L3 puffstage 7-9    3754 white prepupae new    4119 white prepupae 12hr    2385 white prepupae 24hr    2499 pupae 2d postWPP    1796 pupae 3d postWPP    1048 pupae 4d postWPP    1421 adult male 01day    1510 adult male 05day    1765 adult male 30day    1748 adult female 01day    1995 adult female 05day    2302 adult female 30day    2380 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    2649 embryo 02-04hr    1000 embryo 04-06hr    2982 embryo 06-08hr    3481 embryo 08-10hr    2653 embryo 10-12hr    2620 embryo 12-14hr    1434 embryo 14-16hr    1276 embryo 16-18hr    1021 embryo 18-20hr    928 embryo 20-22hr    837 embryo 22-24hr    775 larva L1    1101 larva L2    1200 larva L3 12hr old    1376 larva L3 puffstage 1-2    2230 larva L3 puffstage 3-6    3295 larva L3 puffstage 7-9    3754 white prepupae new    4119 white prepupae 12hr    2385 white prepupae 24hr    2499 pupae 2d postWPP    1796 pupae 3d postWPP    1048 pupae 4d postWPP    1421 adult male 01day    1510 adult male 05day    1765 adult male 30day    1748 adult female 01day    1995 adult female 05day    2302 adult female 30day    2380 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0038166 expression level Developmental Stage   Expression Level embryo 00-02hr    2649 embryo 02-04hr    1000 embryo 04-06hr    2982 embryo 06-08hr    3481 embryo 08-10hr    2653 embryo 10-12hr    2620 embryo 12-14hr    1434 embryo 14-16hr    1276 embryo 16-18hr    1021 embryo 18-20hr    928 embryo 20-22hr    837 embryo 22-24hr    775 larva L1    1101 larva L2    1200 larva L3 12hr old    1376 larva L3 puffstage 1-2    2230 larva L3 puffstage 3-6    3295 larva L3 puffstage 7-9    3754 white prepupae new    4119 white prepupae 12hr    2385 white prepupae 24hr    2499 pupae 2d postWPP    1796 pupae 3d postWPP    1048 pupae 4d postWPP    1421 adult male 01day    1510 adult male 05day    1765 adult male 30day    1748 adult female 01day    1995 adult female 05day    2302 adult female 30day    2380 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (2649) embryo 02-04hr  (1000) embryo 04-06hr  (2982) embryo 06-08hr  (3481) embryo 08-10hr  (2653) embryo 10-12hr  (2620) embryo 12-14hr  (1434) embryo 14-16hr  (1276) embryo 16-18hr  (1021) embryo 18-20hr  (928) embryo 20-22hr  (837) embryo 22-24hr  (775) larva L1  (1101) larva L2  (1200) larva L3 12hr old  (1376) larva L3 puffstage 1-2  (2230) larva L3 puffstage 3-6  (3295) larva L3 puffstage 7-9  (3754) white prepupae new  (4119) white prepupae 12hr  (2385) white prepupae 24hr  (2499) pupae 2d postWPP  (1796) pupae 3d postWPP  (1048) pupae 4d postWPP  (1421) adult male 01day  (1510) adult male 05day  (1765) adult male 30day  (1748) adult female 01day  (1995) adult female 05day  (2302) adult female 30day  (2380) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (2649) embryo 02-04hr    1000 embryo 04-06hr  (2982) embryo 06-08hr  (3481) embryo 08-10hr  (2653) embryo 10-12hr  (2620) embryo 12-14hr  1434 embryo 14-16hr    1276 embryo 16-18hr    1021 embryo 18-20hr    928 embryo 20-22hr    837 embryo 22-24hr    775 larva L1    1101 larva L2    1200 larva L3 12hr old    1376 larva L3 puffstage 1-2  2230 larva L3 puffstage 3-6  (3295) larva L3 puffstage 7-9  (3754) white prepupae new  (4119) white prepupae 12hr  2385 white prepupae 24hr  (2499) pupae 2d postWPP  1796 pupae 3d postWPP    1048 pupae 4d postWPP  1421 adult male 01day  1510 adult male 05day  1765 adult male 30day  1748 adult female 01day  1995 adult female 05day  2302 adult female 30day  2380 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    2649 embryo 02-04hr    1000 embryo 04-06hr    2982 embryo 06-08hr    3481 embryo 08-10hr    2653 embryo 10-12hr    2620 embryo 12-14hr    1434 embryo 14-16hr    1276 embryo 16-18hr    1021 embryo 18-20hr    928 embryo 20-22hr    837 embryo 22-24hr    775 larva L1    1101 larva L2    1200 larva L3 12hr old    1376 larva L3 puffstage 1-2    2230 larva L3 puffstage 3-6    3295 larva L3 puffstage 7-9    3754 white prepupae new    4119 white prepupae 12hr    2385 white prepupae 24hr    2499 pupae 2d postWPP    1796 pupae 3d postWPP    1048 pupae 4d postWPP    1421 adult male 01day    1510 adult male 05day    1765 adult male 30day    1748 adult female 01day    1995 adult female 05day    2302 adult female 30day    2380 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    2649 embryo 02-04hr    1000 embryo 04-06hr    2982 embryo 06-08hr    3481 embryo 08-10hr    2653 embryo 10-12hr    2620 embryo 12-14hr    1434 embryo 14-16hr    1276 embryo 16-18hr    1021 embryo 18-20hr    928 embryo 20-22hr    837 embryo 22-24hr    775 larva L1    1101 larva L2    1200 larva L3 12hr old    1376 larva L3 puffstage 1-2    2230 larva L3 puffstage 3-6    3295 larva L3 puffstage 7-9    3754 white prepupae new    4119 white prepupae 12hr    2385 white prepupae 24hr    2499 pupae 2d postWPP    1796 pupae 3d postWPP    1048 pupae 4d postWPP    1421 adult male 01day    1510 adult male 05day    1765 adult male 30day    1748 adult female 01day    1995 adult female 05day    2302 adult female 30day    2380 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0038166    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0038166 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval central nervous system, adult crop, adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval salivary gland, larval trachea, adult female reproductive system, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0038166 expression level Tissue   Expression Level Larval Central Nervous System    195.9 Larval Midgut    95.7 Larval Hindgut    145.7 Larval Malpighian Tubules    174.8 Larval Fat Body    108.6 Larval Salivary Gland    113.7 Larval Trachea    232.05 Larval Carcass    216.575 Adult Head    82.1 Adult Eye    95.075 Adult Brain    82.9 Adult Thoracic-Abdominal Ganglion    65.5 Adult Crop    180.9 Adult Midgut    110.2 Adult Hindgut    152.3 Adult Malpighian Tubules    150.6 Adult Fat Body    145.2 Adult Salivary Gland    75.9 Adult Heart    221.525 Adult VirginFemale Spermatheca    177.4 Adult InseminatedFemale Spermatheca    187.9 Adult Ovary    140.3 Adult Testis    63.3 Adult Male Accessory Gland    97.2 Adult Carcass    132.1 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    195.9 Larval Midgut    95.7 Larval Hindgut    145.7 Larval Malpighian Tubules    174.8 Larval Fat Body    108.6 Larval Salivary Gland    113.7 Larval Trachea    232.05 Larval Carcass    216.575 Adult Head    82.1 Adult Eye    95.075 Adult Brain    82.9 Adult Thoracic-Abdominal Ganglion    65.5 Adult Crop    180.9 Adult Midgut    110.2 Adult Hindgut    152.3 Adult Malpighian Tubules    150.6 Adult Fat Body    145.2 Adult Salivary Gland    75.9 Adult Heart    221.525 Adult VirginFemale Spermatheca    177.4 Adult InseminatedFemale Spermatheca    187.9 Adult Ovary    140.3 Adult Testis    63.3 Adult Male Accessory Gland    97.2 Adult Carcass    132.1 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    195.9 Larval Midgut    95.7 Larval Hindgut    145.7 Larval Malpighian Tubules    174.8 Larval Fat Body    108.6 Larval Salivary Gland    113.7 Larval Trachea    232.05 Larval Carcass    216.575 Adult Head    82.1 Adult Eye    95.075 Adult Brain    82.9 Adult Thoracic-Abdominal Ganglion    65.5 Adult Crop    180.9 Adult Midgut    110.2 Adult Hindgut    152.3 Adult Malpighian Tubules    150.6 Adult Fat Body    145.2 Adult Salivary Gland    75.9 Adult Heart    221.525 Adult VirginFemale Spermatheca    177.4 Adult InseminatedFemale Spermatheca    187.9 Adult Ovary    140.3 Adult Testis    63.3 Adult Male Accessory Gland    97.2 Adult Carcass    132.1 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    195.9 Larval Midgut    95.7 Larval Hindgut    145.7 Larval Malpighian Tubules    174.8 Larval Fat Body    108.6 Larval Salivary Gland    113.7 Larval Trachea    232.05 Larval Carcass    216.575 Adult Head    82.1 Adult Eye    95.075 Adult Brain    82.9 Adult Thoracic-Abdominal Ganglion    65.5 Adult Crop    180.9 Adult Midgut    110.2 Adult Hindgut    152.3 Adult Malpighian Tubules    150.6 Adult Fat Body    145.2 Adult Salivary Gland    75.9 Adult Heart    221.525 Adult VirginFemale Spermatheca    177.4 Adult InseminatedFemale Spermatheca    187.9 Adult Ovary    140.3 Adult Testis    63.3 Adult Male Accessory Gland    97.2 Adult Carcass    132.1 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0038166 expression level Tissue   Expression Level Larval Central Nervous System    195.9 Larval Midgut    95.7 Larval Hindgut    145.7 Larval Malpighian Tubules    174.8 Larval Fat Body    108.6 Larval Salivary Gland    113.7 Larval Trachea    232.05 Larval Carcass    216.575 Adult Head    82.1 Adult Eye    95.075 Adult Brain    82.9 Adult Thoracic-Abdominal Ganglion    65.5 Adult Crop    180.9 Adult Midgut    110.2 Adult Hindgut    152.3 Adult Malpighian Tubules    150.6 Adult Fat Body    145.2 Adult Salivary Gland    75.9 Adult Heart    221.525 Adult VirginFemale Spermatheca    177.4 Adult InseminatedFemale Spermatheca    187.9 Adult Ovary    140.3 Adult Testis    63.3 Adult Male Accessory Gland    97.2 Adult Carcass    132.1 Expression Level Scale  None   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    195.9 Larval Midgut    95.7 Larval Hindgut    145.7 Larval Malpighian Tubules    174.8 Larval Fat Body    108.6 Larval Salivary Gland    113.7 Larval Trachea    232.05 Larval Carcass    216.575 Adult Head    82.1 Adult Eye    95.075 Adult Brain    82.9 Adult Thoracic-Abdominal Ganglion    65.5 Adult Crop    180.9 Adult Midgut    110.2 Adult Hindgut    152.3 Adult Malpighian Tubules    150.6 Adult Fat Body    145.2 Adult Salivary Gland    75.9 Adult Heart    221.525 Adult VirginFemale Spermatheca    177.4 Adult InseminatedFemale Spermatheca    187.9 Adult Ovary    140.3 Adult Testis    63.3 Adult Male Accessory Gland    97.2 Adult Carcass    132.1 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    195.9 Larval Midgut    95.7 Larval Hindgut    145.7 Larval Malpighian Tubules    174.8 Larval Fat Body    108.6 Larval Salivary Gland    113.7 Larval Trachea    232.05 Larval Carcass    216.575 Adult Head    82.1 Adult Eye    95.075 Adult Brain    82.9 Adult Thoracic-Abdominal Ganglion    65.5 Adult Crop    180.9 Adult Midgut    110.2 Adult Hindgut    152.3 Adult Malpighian Tubules    150.6 Adult Fat Body    145.2 Adult Salivary Gland    75.9 Adult Heart    221.525 Adult VirginFemale Spermatheca    177.4 Adult InseminatedFemale Spermatheca    187.9 Adult Ovary    140.3 Adult Testis    63.3 Adult Male Accessory Gland    97.2 Adult Carcass    132.1 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    195.9 Larval Midgut    95.7 Larval Hindgut    145.7 Larval Malpighian Tubules    174.8 Larval Fat Body    108.6 Larval Salivary Gland    113.7 Larval Trachea    232.05 Larval Carcass    216.575 Adult Head    82.1 Adult Eye    95.075 Adult Brain    82.9 Adult Thoracic-Abdominal Ganglion    65.5 Adult Crop    180.9 Adult Midgut    110.2 Adult Hindgut    152.3 Adult Malpighian Tubules    150.6 Adult Fat Body    145.2 Adult Salivary Gland    75.9 Adult Heart    221.525 Adult VirginFemale Spermatheca    177.4 Adult InseminatedFemale Spermatheca    187.9 Adult Ovary    140.3 Adult Testis    63.3 Adult Male Accessory Gland    97.2 Adult Carcass    132.1 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    82.1   NA  Eye    95.075   NA  Brain    82.9   195.9  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    65.5   NA  Crop    180.9   95.7  Midgut    110.2   145.7  Hindgut    152.3   174.8  Malpighian Tubules    150.6   108.6  Fat Body    145.2   113.7  Salivary Gland    75.9   NA  Heart    221.525   232.05  Trachea    NA   NA  VirginFemale Spermatheca    177.4   NA  InseminatedFemale Spermatheca    187.9   NA  Ovary    140.3   NA  Testis    63.3   NA  Male Accessory Gland    97.2   216.575  Carcass    132.1 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_23
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0038166 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG9588-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for CG9588 Stages(s) 1-3 Stages(s) 7-8 Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable, with Scer\GAL4pnr-MD237 CG9588GD14259 Phenotype manifest in Allele
Classical Alleles ( 0 )
For All Classical Alleles Show
Allele of CG9588 Class Mutagen Stocks Known lesion
Alleles Carried on Transgenic Constructs ( 4 )
For All Alleles Carried on Transgenic Constructs Show
Allele of CG9588 Class Mutagen Stocks Known lesion CG9588GD14259 in vitro construct - RNAi in vitro construct - regulatory fusion 3 Yes CG9588HM05013 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes CG9588KK104817 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes CG9588tBa in vitro construct - genomic fragment 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3R)Exel6169 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD14259} NA P{KK104817} NA P{TRiP.HM05013} NA characterization construct P{lkb1+tBa} NA
Insertions
	Type of insertions Name Expression data
Gene Ontology: Function, Process & Cellular Component ( 3 unique terms )
Terms Based on Experimental Evidence ( 1 term )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
response to DNA damage stimulus inferred from mutant phenotype (Ravi et al., 2009)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 2 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
proteolysis inferred from sequence or structural similarity with NCBI_gi:4506235 (FlyBase, 1992-)
Cellular Component
CV term Evidence References
proteasome regulatory particle inferred from sequence or structural similarity with NCBI_gi:4506235 (FlyBase, 1992-)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions CG9588 allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 66752 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0038166 DroID - A comprehensive database of gene and protein interactions. • FBgn0038166 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 41672
Orthologs
Genome-wide drosophilid orthologs	Dana\GF17366 Dere\GG17031 Dgri\GH19055 Dmoj\GI10690 Dper\GL23970 Dpse\GA21895 Dsec\GM25915 Dsim\GD20482 Dvir\GJ23109 Dwil\GK13330 Dyak\GE24424
Curated drosophilid orthologs	Dpse\GA21895
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL013890-PA Aedes aegypti (mosquito) AGAP000201-PA Anopheles gambiae (mosquito) XP_623259.1 Apis mellifera (honey bee) At5g57950.1 Arabidopsis thaliana (wall cress) 90037 Batrachochytrium dendrobatidis (chytrid fungus) 114341 Branchiostoma floridae (lancelet) BGIBMGA004419-PA Bombyx mori (silk worm) ENSBTAP00000029636 Bos taurus (bovine) CAL0000640 Candida albicans (a form of yeast) CN29659 Caenorhabditis brenneri (small nematode) CBP08842 Caenorhabditis briggsae (nematode) CE25810 Caenorhabditis elegans (worm) ENSCAFP00000011871 Canis familiaris (dog) CAGL0C03762g Candida glabrata (haploid yeast) Chro.50142 Cryptosporidium hominis (obligate parasite) JA16095 Caenorhabditis japonica (nematode) CMR331C Cyanidioschyzon merolae (red alga) cn01317 Cryptococcus neoformans (yeast-like fungus) cgd5_2360 Cryptosporidium parvum (protozoan parasite) CPIJ005564 Culex pipens (mosquito) ENSCPOP00000017814 Cavia porcellus (guinea pig) 115832 Chlamidomonas reinhardtii (green alga) RP25845 Caenorhabditis remanei (nematode) ENSCSAVP00000018486 Ciona savignyi (sedentary tunicate) 171080 Capitella spl (polychaete worm) DDB0232989 Dictyostelium discoideum (amoeba) DEHA2B15444g Debaryomyces Hansenii (yeast) 302228 Daphnia pulex (daphnia) 309024 Daphnia pulex (daphnia) ENSDARP00000025305 Danio rerio (zebra fish) ENSECAP00000017805 Equus caballus (horse) XP_649580 Entamoeba histolytica (anaerobic protozoan) ENSGACP00000010716 Gymnopilus aculeatus (mushroom) ENSGALP00000006932 Gallus gallus (chicken) 68925 Hypsipyla robusta (cedar shoot borer) ENSP00000261817 Homo sapiens (human) ISCW018679-PA Ixodes scapularis (deer tick) KLLA0D14135g Kluyveromyces lactis (yeast) 182313 Lottia gigantea (owl limpet) LmjF16.0290 Leishmania major (virus) 27868 Monocosta brevicollis (choanoflagellate) ENSMODP00000015212 Monodelphis domestica (gray opossum) ENSMMUP00000038483 Macaca mulatta (rhesus monkey) ENSMUSP00000053348 Mus musculus (house mouse) 183435 Nematostella vectensis (starlet anemone) XP_001602875.1 Nasonia vitripennis (wasp) ENSOANP00000009942 Ornithorynchus anatinus (platypus) ENSORLP00000007423 Oryzias latipes (japanese killifish) LOC_Os09g25310.1 Oryza sativa (asian rice) PFC0785c Plasmodium falciparum (protozoal parasite) PHUM005018-PA Pediculus humanus (human body louse) PP08477 Pristionchus pacificus (nematode) 115990 Physcomitrella patens (moss) ENSPPYP00000005762 Pongo pygmaeus (orangutan) 82792 Phytophthora ramorum (sudden oak death pathogen) 108853 Phytophthora sojae (root rot pathogen) 653576 Populus trichocarpa (black cottonwood) ENSPTRP00000009454 Pan troglodytes (chimpanzee) PVX_095340 Plasmodium vivax (protozoal parasite) ENSRNOP00000001812 Rattus norvegicus (norway rat) 147782 Sorghum bicolor (sorghum) YIL007C Saccharomyces cerevisiae (budding yeast) SPAC2H10.02c Schizosaccharomyces pombe (fission yeast) XP_785837.1 Strongylocentrotus purpuratus (purple sea urchin) 24455 Trichoplax adhaerens (metazoa) XP_968374.1 Tribolium castaneum (red flour beetle) Tc00.1047053506743.150 Trypanosoma cruzi (parasitic trypanosome) ENSTNIP00000018903 Tetraodon nigroviridis (green spotted pufferfish) 34219 Thalassiosira pseudonana (marine diatom) ENSTRUP00000016825 Takifugu rubripes (pufferfish Takifugu) 3697.m00059 Tetrahymena thermophila (ciliate protozoa) 96423.m00188 Trichomonas vaginalis (parasitic flagellated protozoan) ENSXETP00000008167 Xenopus tropicalis (frog) YALI0E19470g Yarrowia lipolytica (nonconventional yeast) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB18782 NV15117 LH14097 ISCW024720 ISCW018679 FBgn0241541 FBgn0215339 FBgn0210211 FBgn0191953 FBgn0180771 JGI_V11_309024 JGI_V11_302228 FBgn0081880 FBgn0161560 FBgn0133454 FBgn0126522 FBgn0109259 FBgn0094384 CPIJ005564 BGIBMGA004419 ACYPI001714 GB15826 AGAP000201 AAEL013890 PHUM235790 GLEAN_09422
Stocks & Reagents
Stocks Listed in FlyBase ( 5 )
Bloomington	28527 y1 v1; P{TRiP.HM05013}attP2
VDRC	v100126 P{KK104817}VIE-260B v27024 w1118 P{GD14259}v27024 v47762 w1118; P{GD14259}v47762 v47763 w1118; P{GD14259}v47763
Genomic Clones ( 2 )
	BACR03J04 BACR30G22 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 33 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	RE14241
Other clones	DPiM_RE14241
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT09488 GM10942 RH05056 RH05080 RH26095 RH28585 RH35530 RH44852 SD16505
Other clones	272926 CK01147 Dmel_neb_015074_0821_1280 Dmel_neb_015871_0949_1150 EC17547 RM01094 RM01194 RM01294 RM01394 RM01494 RM01694 RM01794 RP01326 RP01529 RP01589 RP001005260 RP001020372 RP001025560 RP001034723 RP001043413 RP001048779 RP001049293
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0038166 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 41672
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_142044 RefSeq (Proteins) • NP_650301 DDBJ / EMBL / GenBank • AAF54971 AAL48686 AY071064 BI230542 Entrez Gene - A searchable database of RefSeq genes. • 41672 UniProtKB/TrEMBL • Q9VFS8
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • PDZ/DHR/GLGF (IPR001478)
Linkouts
	BioGRID - A database of protein and genetic interactions • 66752 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0038166 DroID - A comprehensive database of gene and protein interactions. • FBgn0038166 DRSC - Results from RNAi screens. • FBgn0038166 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0038166 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG9588-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0038166 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 41672 InParanoid A subset of ortholog calls from InParanoid. • AAEL013890-PA Aedes aegypti (mosquito) AGAP000201-PA Anopheles gambiae (mosquito) XP_623259.1 Apis mellifera (honey bee) At5g57950.1 Arabidopsis thaliana (wall cress) 90037 Batrachochytrium dendrobatidis (chytrid fungus) 114341 Branchiostoma floridae (lancelet) BGIBMGA004419-PA Bombyx mori (silk worm) ENSBTAP00000029636 Bos taurus (bovine) CAL0000640 Candida albicans (a form of yeast) CN29659 Caenorhabditis brenneri (small nematode) CBP08842 Caenorhabditis briggsae (nematode) CE25810 Caenorhabditis elegans (worm) ENSCAFP00000011871 Canis familiaris (dog) CAGL0C03762g Candida glabrata (haploid yeast) Chro.50142 Cryptosporidium hominis (obligate parasite) JA16095 Caenorhabditis japonica (nematode) CMR331C Cyanidioschyzon merolae (red alga) cn01317 Cryptococcus neoformans (yeast-like fungus) cgd5_2360 Cryptosporidium parvum (protozoan parasite) CPIJ005564 Culex pipens (mosquito) ENSCPOP00000017814 Cavia porcellus (guinea pig) 115832 Chlamidomonas reinhardtii (green alga) RP25845 Caenorhabditis remanei (nematode) ENSCSAVP00000018486 Ciona savignyi (sedentary tunicate) 171080 Capitella spl (polychaete worm) DDB0232989 Dictyostelium discoideum (amoeba) DEHA2B15444g Debaryomyces Hansenii (yeast) 302228 Daphnia pulex (daphnia) 309024 Daphnia pulex (daphnia) ENSDARP00000025305 Danio rerio (zebra fish) ENSECAP00000017805 Equus caballus (horse) XP_649580 Entamoeba histolytica (anaerobic protozoan) ENSGACP00000010716 Gymnopilus aculeatus (mushroom) ENSGALP00000006932 Gallus gallus (chicken) 68925 Hypsipyla robusta (cedar shoot borer) ENSP00000261817 Homo sapiens (human) ISCW018679-PA Ixodes scapularis (deer tick) KLLA0D14135g Kluyveromyces lactis (yeast) 182313 Lottia gigantea (owl limpet) LmjF16.0290 Leishmania major (virus) 27868 Monocosta brevicollis (choanoflagellate) ENSMODP00000015212 Monodelphis domestica (gray opossum) ENSMMUP00000038483 Macaca mulatta (rhesus monkey) ENSMUSP00000053348 Mus musculus (house mouse) 183435 Nematostella vectensis (starlet anemone) XP_001602875.1 Nasonia vitripennis (wasp) ENSOANP00000009942 Ornithorynchus anatinus (platypus) ENSORLP00000007423 Oryzias latipes (japanese killifish) LOC_Os09g25310.1 Oryza sativa (asian rice) PFC0785c Plasmodium falciparum (protozoal parasite) PHUM005018-PA Pediculus humanus (human body louse) PP08477 Pristionchus pacificus (nematode) 115990 Physcomitrella patens (moss) ENSPPYP00000005762 Pongo pygmaeus (orangutan) 82792 Phytophthora ramorum (sudden oak death pathogen) 108853 Phytophthora sojae (root rot pathogen) 653576 Populus trichocarpa (black cottonwood) ENSPTRP00000009454 Pan troglodytes (chimpanzee) PVX_095340 Plasmodium vivax (protozoal parasite) ENSRNOP00000001812 Rattus norvegicus (norway rat) 147782 Sorghum bicolor (sorghum) YIL007C Saccharomyces cerevisiae (budding yeast) SPAC2H10.02c Schizosaccharomyces pombe (fission yeast) XP_785837.1 Strongylocentrotus purpuratus (purple sea urchin) 24455 Trichoplax adhaerens (metazoa) XP_968374.1 Tribolium castaneum (red flour beetle) Tc00.1047053506743.150 Trypanosoma cruzi (parasitic trypanosome) ENSTNIP00000018903 Tetraodon nigroviridis (green spotted pufferfish) 34219 Thalassiosira pseudonana (marine diatom) ENSTRUP00000016825 Takifugu rubripes (pufferfish Takifugu) 3697.m00059 Tetrahymena thermophila (ciliate protozoa) 96423.m00188 Trichomonas vaginalis (parasitic flagellated protozoan) ENSXETP00000008167 Xenopus tropicalis (frog) YALI0E19470g Yarrowia lipolytica (nonconventional yeast) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 41672 modMine - Data generated by the modENCODE project. • FBgn0038166 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB18782 NV15117 LH14097 ISCW024720 ISCW018679 FBgn0241541 FBgn0215339 FBgn0210211 FBgn0191953 FBgn0180771 JGI_V11_309024 JGI_V11_302228 FBgn0081880 FBgn0161560 FBgn0133454 FBgn0126522 FBgn0109259 FBgn0094384 CPIJ005564 BGIBMGA004419 ACYPI001714 GB15826 AGAP000201 AAEL013890 PHUM235790 GLEAN_09422
Synonyms & Secondary IDs ( 2 )
Reported As
Symbol Synonym	9588 (Ravi et al., 2009) CG9588 (Rasmussen and Kellis, 2007, Bonaccorsi et al., 2007, Barbash and Lorigan, 2007, Keleman et al., 2009.8.5, Perkins et al., 2009)
Name Synonym
Secondary FlyBase IDs
References ( 16 )
Research paper	Ravi et al., 2009, PLoS Genet. 5(6): e1000527 A network of conserved damage survival pathways revealed by a genomic RNAi screen. [FBrf0208272] Barbash and Lorigan, 2007, J. exp. Zool. B. Molec. Dev. Evol. 308B(1): 74--84 Lethality in Drosophila melanogaster/Drosophila simulans species hybrids is not associated with substantial transcriptional misregulation. [FBrf0201868] Bonaccorsi et al., 2007, Development 134(11): 2183--2193 The Drosophila Lkb1 kinase is required for spindle formation and asymmetric neuroblast division. [FBrf0201104] Rasmussen and Kellis, 2007, Genome Res. 17(12): 1932--1942 Accurate gene-tree reconstruction by learning gene- and species-specific substitution rates across multiple complete genomes. [FBrf0202901]
Supplementary material	The modENCODE Consortium, 2010, Science 330(6012): DataS14: Gene co-expression clusters. [FBrf0213979] Mummery-Widmer et al., 2009, Nature 458(7241): Supplementary Table 2 - Genome-wide bristle screen results. [FBrf0214518] Giot et al., 2003, Science 302(5651): Tables S1 to S7. [FBrf0166452]
Personal communication to FlyBase	Keleman et al., 2009.8.5, RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0208510] Perkins et al., 2009, Update to TRiP stock collection. Update to TRiP stock collection. [FBrf0208864] Dickson et al., 2007.7.18, RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0200327] FlyBase Curators et al., 2004-, Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. [FBrf0174215] Ryder, 2004.4.26, Exelixis CG deletion data. Exelixis CG deletion data. [FBrf0184335]
FlyBase analysis	FlyBase, 1992-, FlyBase curation FlyBase curation. [FBrf0105495]
Computer file	BDGP Project Members, 2000-, Berkeley Drosophila Genome Project. Berkeley Drosophila Genome Project. [FBrf0125078]
Curated genome annotation	Ashburner, 1999.11, [Annotations performed at the Celera Jamboreee.] [Annotations performed at the Celera Jamboreee.] [FBrf0126651]