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General Information
Symbol
Dmel\foxo
Species
D. melanogaster
Name
forkhead box, sub-group O
Annotation Symbol
CG3143
Feature Type
FlyBase ID
FBgn0038197
Gene Model Status
Stock Availability
Gene Snapshot
In progress.Contributions welcome.
Also Known As
dFOXO, Forkhead box O, forkhead box sub-group O, forkhead transcription factor, FKHR
Key Links
Genomic Location
Cytogenetic map
Sequence location
3R:14,056,945..14,087,978 [+]
Recombination map
3-54
Sequence
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
Function
GO Summary Ribbons
Protein Family (UniProt)
-
Summaries
Gene Group (FlyBase)
FORK HEAD BOX TRANSCRIPTION FACTORS -
The forkhead box family of transcription factors are sequence-specific DNA binding proteins that regulate transcription. They are characterized by approximately 110 amino acid DNA-binding domain known as the forkhead or winged helix. (Adapted from FBrf0173142).
Pathway (FlyBase)
Insulin-like Receptor Signaling Pathway Core Components -
The Insulin-like Receptor (IR) signaling pathway in Drosophila is initiated by the binding of an insulin-like peptides to the Insulin-like receptor (InR). (Adapted from FBrf0232297, FBrf0230017 and FBrf0229989.)
Protein Function (UniProtKB)
Transcription factor involved in the regulation of the insulin signaling pathway. Consistently activates both the downstream target Thor\d4EBP and the feedback control target InR. Involved in negative regulation of the cell cycle, modulating cell growth and proliferation. In response to cellular stresses, such as nutrient deprivation or increased levels of reactive oxygen species, foxo is activated and inhibits growth through the action of target genes such as Thor. Foxo activated in the adult fat body can regulate lifespan in adults; an insulin peptide itself may function as one secondary messenger of insulin-regulated aging. Also regulates Lip4, homolog of human acid lipases, thereby acting as a key modulator of lipid metabolism by insulin signaling and integrates insulin responses to glucose and lipid homeostasis.
(UniProt, Q95V55)
Summary (Interactive Fly)
forkhead domain transcription factor - a target of the insulin receptor signaling pathway - modulates growth and proliferation - regulates RNA interference and protects from RNA virus infection - promotes Wingless signaling - A Toll receptor-FoxO pathway represses Pavarotti/MKLP1 to promote microtubule dynamics in motoneurons
Gene Model and Products
Number of Transcripts
5
Number of Unique Polypeptides
3

Please see the GBrowse view of Dmel\foxo or the JBrowse view of Dmel\foxo for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model
Gene model reviewed during 5.48
Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.
Annotated transcripts do not represent all supported alternative splices within 5' UTR.
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 6.02
Sequence Ontology: Class of Gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
FBtr0082886
3939
613
FBtr0082887
3548
613
FBtr0305052
3708
622
FBtr0337094
3450
622
FBtr0346723
3566
619
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
FBpp0089343
67.4
613
5.42
FBpp0089344
67.4
613
5.42
FBpp0293589
68.3
622
5.29
FBpp0308010
68.3
622
5.29
FBpp0312334
68.1
619
5.58
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

622 aa isoforms: foxo-PF, foxo-PG
613 aa isoforms: foxo-PB, foxo-PC
Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Subunit Structure (UniProtKB)
Interacts with melt.
(UniProt, Q95V55)
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\foxo using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Gene Ontology (53 terms)
Molecular Function (7 terms)
Terms Based on Experimental Evidence (4 terms)
CV Term
Evidence
References
Terms Based on Predictions or Assertions (4 terms)
CV Term
Evidence
References
inferred from biological aspect of ancestor with PANTHER:PTN002908599
(assigned by GO_Central )
inferred from biological aspect of ancestor with PANTHER:PTN002908599
(assigned by GO_Central )
inferred from biological aspect of ancestor with PANTHER:PTN002908599
(assigned by GO_Central )
inferred from biological aspect of ancestor with PANTHER:PTN002908599
(assigned by GO_Central )
Biological Process (43 terms)
Terms Based on Experimental Evidence (42 terms)
CV Term
Evidence
References
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from genetic interaction with FLYBASE:aop; FB:FBgn0000097
inferred from genetic interaction with FLYBASE:pnt; FB:FBgn0003118
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
(assigned by UniProt )
inferred from mutant phenotype
inferred from genetic interaction with FLYBASE:Akt1; FB:FBgn0010379
inferred from genetic interaction with FLYBASE:Pi3K92E; FB:FBgn0015279
inferred from genetic interaction with FLYBASE:chico; FB:FBgn0024248
inferred from genetic interaction with FLYBASE:Tsc1; FB:FBgn0026317
inferred from genetic interaction with FLYBASE:Pten; FB:FBgn0026379
inferred from genetic interaction with FLYBASE:InR; FB:FBgn0283499
inferred from mutant phenotype
inferred from genetic interaction with FLYBASE:InR; FB:FBgn0283499
inferred from mutant phenotype
(assigned by UniProt )
inferred from mutant phenotype
(assigned by UniProt )
inferred from mutant phenotype
inferred from mutant phenotype
(assigned by UniProt )
inferred from mutant phenotype
(assigned by UniProt )
inferred from mutant phenotype
inferred from mutant phenotype
inferred from genetic interaction with FLYBASE:mnb; FB:FBgn0259168
inferred from mutant phenotype
inferred from direct assay
inferred from mutant phenotype
inferred from mutant phenotype
(assigned by UniProt )
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
(assigned by UniProt )
inferred from mutant phenotype
inferred from direct assay
inferred from mutant phenotype
inferred from mutant phenotype
Terms Based on Predictions or Assertions (4 terms)
CV Term
Evidence
References
inferred from biological aspect of ancestor with PANTHER:PTN002908599
(assigned by GO_Central )
inferred from biological aspect of ancestor with PANTHER:PTN000215135
(assigned by GO_Central )
inferred from biological aspect of ancestor with PANTHER:PTN002908599
(assigned by GO_Central )
inferred from biological aspect of ancestor with PANTHER:PTN002908599
(assigned by GO_Central )
Cellular Component (3 terms)
Terms Based on Experimental Evidence (3 terms)
CV Term
Evidence
References
inferred from direct assay
(assigned by UniProt )
inferred from direct assay
inferred from direct assay
(assigned by UniProt )
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
inferred from biological aspect of ancestor with PANTHER:PTN002908599
(assigned by GO_Central )
inferred by curator from GO:0001228
inferred from biological aspect of ancestor with PANTHER:PTN002908599
(assigned by GO_Central )
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
organism

Comment: maternally deposited

organism | ubiquitous | uniform

Comment: maternally deposited

Additional Descriptive Data
foxo transcript is maternally expressed; the maternal contribution completely disappears prior to cellularization. Somatic expression is undetectable until embryonic stage 11; transcript is expressed in the endoderm and ectoderm at embryonic stage 12. Lower levels of foxo transcript are observed in the ventral portions of the thoracic and head segments; strong expression is observed in labral segment. A cluster of foxo-expressing cells, possibly associated with the stomatogastric nervous system, is observed near the developing proventriculus. Expression in the epidermis of the trunk segments and in the endoderm persists into later stages
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
western blot
Stage
Tissue/Position (including subcellular localization)
Reference
Additional Descriptive Data
foxo protein is localized to the nucleus of cells in the prothoracic gland in newly ecdysed third instar larvae. In fed larvae, by 5 hours after the beginning of the third instar, foxo protein is evenly dispersed; by 10 hours, it is mostly localized to the cytoplasm of prothoracic gland cells.
foxo staining can be observed in a subset of cells in the ventral nerve cord in embryos and larvae. No repo staining is seen in foxo-positive cells, showing that foxo is not present in repo-positive glia. Co-staining with antibodies against phosphorylated Mad, a marker for motor neurons (FBrf0145176), shows that most motor neurons express foxo, and most foxo-positive cells are motor neurons.
foxo is found predominantly in the neuroblast cytoplasm in late third instar larvae. By 72hrs after pupal formation, foxo can be found in the neuroblast nucleus.
foxo protein is detected in the fat bodies in both the head and abdomen of adult flies.
Marker for
 
Subcellular Localization
CV Term
Evidence
References
inferred from direct assay
(assigned by UniProt )
inferred from direct assay
inferred from direct assay
(assigned by UniProt )
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\foxo in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 36 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 41 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of foxo
Transgenic constructs containing regulatory region of foxo
Deletions and Duplications ( 1 )
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
Sterility
Allele
Other Phenotypes
Allele
Phenotype manifest in
Allele
Orthologs
Human Orthologs (via DIOPT v7.1)
Homo sapiens (Human) (4)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
10 of 15
Yes
Yes
 
10 of 15
Yes
Yes
 
10 of 15
Yes
Yes
8 of 15
No
Yes
Model Organism Orthologs (via DIOPT v7.1)
Mus musculus (laboratory mouse) (4)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
10 of 15
Yes
Yes
 
9 of 15
No
Yes
8 of 15
No
Yes
8 of 15
No
Yes
Rattus norvegicus (Norway rat) (4)
9 of 13
Yes
Yes
8 of 13
No
Yes
7 of 13
No
Yes
2 of 13
No
Yes
Xenopus tropicalis (Western clawed frog) (5)
9 of 12
Yes
Yes
8 of 12
No
Yes
4 of 12
No
Yes
2 of 12
No
Yes
1 of 12
No
Yes
Danio rerio (Zebrafish) (7)
10 of 15
Yes
Yes
10 of 15
Yes
Yes
9 of 15
No
Yes
9 of 15
No
Yes
9 of 15
No
Yes
9 of 15
No
Yes
6 of 15
No
Yes
Caenorhabditis elegans (Nematode, roundworm) (2)
7 of 15
Yes
Yes
1 of 15
No
No
Arabidopsis thaliana (thale-cress) (0)
No records found.
Saccharomyces cerevisiae (Brewer's yeast) (1)
1 of 15
Yes
No
Schizosaccharomyces pombe (Fission yeast) (0)
No records found.
Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG091909DI )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila melanogaster
fruit fly
Drosophila suzukii
Spotted wing Drosophila
Drosophila simulans
Drosophila sechellia
Drosophila erecta
Drosophila yakuba
Drosophila ananassae
Drosophila pseudoobscura pseudoobscura
Drosophila persimilis
Drosophila willistoni
Drosophila virilis
Drosophila mojavensis
Drosophila grimshawi
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG09150AEU )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Musca domestica
House fly
Glossina morsitans
Tsetse fly
Glossina morsitans
Tsetse fly
Lucilia cuprina
Australian sheep blowfly
Mayetiola destructor
Hessian fly
Aedes aegypti
Yellow fever mosquito
Anopheles darlingi
American malaria mosquito
Anopheles gambiae
Malaria mosquito
Culex quinquefasciatus
Southern house mosquito
Culex quinquefasciatus
Southern house mosquito
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W0BSP )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bombyx mori
Silkmoth
Danaus plexippus
Monarch butterfly
Danaus plexippus
Monarch butterfly
Heliconius melpomene
Postman butterfly
Heliconius melpomene
Postman butterfly
Apis florea
Little honeybee
Apis mellifera
Western honey bee
Bombus impatiens
Common eastern bumble bee
Bombus terrestris
Buff-tailed bumblebee
Linepithema humile
Argentine ant
Megachile rotundata
Alfalfa leafcutting bee
Megachile rotundata
Alfalfa leafcutting bee
Nasonia vitripennis
Parasitic wasp
Nasonia vitripennis
Parasitic wasp
Dendroctonus ponderosae
Mountain pine beetle
Dendroctonus ponderosae
Mountain pine beetle
Tribolium castaneum
Red flour beetle
Tribolium castaneum
Red flour beetle
Pediculus humanus
Human body louse
Pediculus humanus
Human body louse
Rhodnius prolixus
Kissing bug
Cimex lectularius
Bed bug
Cimex lectularius
Bed bug
Acyrthosiphon pisum
Pea aphid
Zootermopsis nevadensis
Nevada dampwood termite
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X0BQG )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Ixodes scapularis
Black-legged tick
Stegodyphus mimosarum
African social velvet spider
Stegodyphus mimosarum
African social velvet spider
Tetranychus urticae
Two-spotted spider mite
Daphnia pulex
Water flea
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G06K3 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Ciona intestinalis
Vase tunicate
Gallus gallus
Domestic chicken
Gallus gallus
Domestic chicken
Gallus gallus
Domestic chicken
Gallus gallus
Domestic chicken
Paralogs
Paralogs (via DIOPT v7.1)
Drosophila melanogaster (Fruit fly) (2)
1 of 10
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
Disease Model Summary Ribbon
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 4 )
Potential Models Based on Orthology ( 1 )
Human Ortholog
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 7 )
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease Associations of Human Orthologs (via DIOPT v7.1 and OMIM)
Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
Homo sapiens (Human)
Gene name
Score
OMIM
OMIM Phenotype
DO term
Complementation?
Transgene?
Functional Complementation Data
Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
Interactions
Summary of Physical Interactions
esyN Network Diagram
Show neighbor-neighbor interactions:
Select Layout:
Legend:
Protein
RNA
Selected Interactor(s)
Interactions Browser

Please see the Physical Interaction reports below for full details
protein-protein
Physical Interaction
Assay
References
Summary of Genetic Interactions
esyN Network Diagram
esyN Network Key:
Suppression
Enhancement

Please look at the allele data for full details of the genetic interactions
Starting gene(s)
Interaction type
Interacting gene(s)
Reference
Starting gene(s)
Interaction type
Interacting gene(s)
Reference
External Data
Subunit Structure (UniProtKB)
Interacts with melt.
(UniProt, Q95V55 )
Linkouts
BioGRID - A database of protein and genetic interactions.
DroID - A comprehensive database of gene and protein interactions.
InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
MIST (genetic) - An integrated Molecular Interaction Database
MIST (protein-protein) - An integrated Molecular Interaction Database
Pathways
Gene Group - Pathway Membership (FlyBase)
Insulin-like Receptor Signaling Pathway Core Components -
The Insulin-like Receptor (IR) signaling pathway in Drosophila is initiated by the binding of an insulin-like peptides to the Insulin-like receptor (InR). (Adapted from FBrf0232297, FBrf0230017 and FBrf0229989.)
External Data
Genomic Location and Detailed Mapping Data
Chromosome (arm)
3R
Recombination map
3-54
Cytogenetic map
Sequence location
3R:14,056,945..14,087,978 [+]
FlyBase Computed Cytological Location
Cytogenetic map
Evidence for location
88A5-88A8
Limits computationally determined from genome sequence between P{PZ}flfl01949 and P{lacW}trxj14A6&P{PZ}trx00347
Experimentally Determined Cytological Location
Cytogenetic map
Notes
References
88A-88A
(determined by in situ hybridisation)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Stocks and Reagents
Stocks (42)
Genomic Clones (30)
cDNA Clones (54)
 

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequences
BDGP DGC clones
Other clones
Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

cDNA Clones, End Sequenced (ESTs)
RNAi and Array Information
Linkouts
DRSC - Results frm RNAi screens
GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
Antibody Information
Laboratory Generated Antibodies
Commercially Available Antibodies
 
Other Information
Relationship to Other Genes
Source for database identify of
Source for identity of: foxo CG3143
Source for database merge of
Source for merge of: foxo anon-WO0118547.374
Additional comments
Source for merge of foxo anon-WO0118547.374 was sequence comparison ( date:051113 ).
Other Comments
foxo acts cell autonomously to inhibit the formation of microtubule loops.
foxo plays an important role in the ability of young Drosophila larvae to withstand the stress of nutritional starvation.
foxo controls lifespan and regulates insulin signalling in the brain and fat body.
Thor is a relevant foxo target gene. Cellular stress may activate foxo and inhibit growth through the action of target genes such as Thor.
foxo is a crucial mediator of insulin signalling, mediating the reduction in cell number in insulin-signalling mutants. Epistasis analysis provides strong genetic evidence that foxo is required to mediate the organismal growth arrest that is elicited in insulin-signaling mutants.
Mutants are viable and of normal size, but more sensitive to oxidative stress than wild type. Removal of foxo accelerates the cell cycle at the expense of cell size in a chico background.
foxo appears to be a key transcriptional regulator that controls both downstream target genes responsible for growth as well as upstream feedback targets in the insulin signalling pathway.
Area matching Drosophila EST AA539898.
Origin and Etymology
Discoverer
Etymology
Identification
External Crossreferences and Linkouts ( 88 )
Sequence Crossreferences
NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
Other crossreferences
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
KEGG Genes - Molecular building blocks of life in the genomic space.
KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
modMine - A data warehouse for the modENCODE project
SignaLink - A signaling pathway resource with multi-layered regulatory networks.
Linkouts
BioGRID - A database of protein and genetic interactions.
DroID - A comprehensive database of gene and protein interactions.
DRSC - Results frm RNAi screens
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyMine - An integrated database for Drosophila genomics
Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
MIST (genetic) - An integrated Molecular Interaction Database
MIST (protein-protein) - An integrated Molecular Interaction Database
Synonyms and Secondary IDs (35)
Reported As
Symbol Synonym
FOXO
(Galenza and Foley, 2019, Baranski et al., 2018, Cara et al., 2018, Gruntenko and Rauschenbach, 2018, Lee et al., 2018, Min and Tatar, 2018, Piper and Partridge, 2018, Schultzhaus et al., 2018, Keesey et al., 2017, Lee et al., 2017, Moeller et al., 2017, Murillo-Maldonado and Riesgo-Escovar, 2017, Percival-Smith, 2017, Sheng et al., 2017, Yun et al., 2017, Alfa and Kim, 2016, Brill et al., 2016, Jun et al., 2016, Kim et al., 2016, Niwa and Niwa, 2016, Yaniv and Schuldiner, 2016, Grotewiel and Bettinger, 2015, Kopp et al., 2015, Lashmanova et al., 2015, Tiebe et al., 2015, Liu et al., 2014, Mirth et al., 2014, Mulakkal et al., 2014, Owusu-Ansah and Perrimon, 2014, Piccirillo et al., 2014, Wong et al., 2014, Andersen et al., 2013, Banerjee et al., 2013, Erion and Sehgal, 2013, Erkosar et al., 2013, Ferrandon, 2013, Hyun, 2013, Nässel et al., 2013, Nirala et al., 2013, Shingleton and Frankino, 2013, Sim and Denlinger, 2013, Yamanaka et al., 2013, Dahlgaard et al., 2012, Eleftherianos and Castillo, 2012, Hamilos et al., 2012, Hong et al., 2012, Koh et al., 2012, Kounatidis and Ligoxygakis, 2012, Lv et al., 2012, Mirth and Shingleton, 2012, Noebels et al., 2012, Papatheodorou et al., 2012, Xu et al., 2012, Eliazer and Buszczak, 2011, Harrison and Haddad, 2011, Oldham, 2011, Schiesari et al., 2011, Slack et al., 2011, Wang et al., 2011, Zhang et al., 2011, Becker et al., 2010, Birse et al., 2010, Bland et al., 2010, Francis et al., 2010, Amcheslavsky et al., 2009, Hyun et al., 2009, Lee et al., 2009, Mojsilovic-Petrovic et al., 2009, Nuzhdin et al., 2009, Tain et al., 2009, Harvey et al., 2008, Lee et al., 2008, Owusu-Ansah et al., 2008, Skorupa et al., 2008, Teleman et al., 2008, Dionne, 2007, Dionne and Schneider, 2007, Fuss et al., 2007, Hietakangas and Cohen, 2007, Lavery et al., 2007, Lee and Chung, 2007, Libert, 2007, Scott et al., 2007, Tong et al., 2007, Zheng et al., 2007, Zinke et al., 2007, Dionne and Schneider, 2006, Fuss et al., 2006, Hennig et al., 2006, Lavery and Stern, 2006, Takacs-Vellai, 2006, Wu and Brown, 2006, Jordan et al., 2005, Nijhout, 2003, Puig et al., 2003)
anon-WO0118547.374
dFOXO
(Bayliak et al., 2019, Lushchak et al., 2019, Westfall et al., 2019, Álvarez-Rendón et al., 2018, Zhang et al., 2018, Antikainen et al., 2017, Blice-Baum et al., 2017, Kang et al., 2017, Mathew et al., 2017, Mattila and Hietakangas, 2017, Tokusumi et al., 2017, Whon et al., 2017, Zhu et al., 2017, Altintas et al., 2016, Donovan and Marr, 2016, Mahoney et al., 2016, Webb et al., 2016, Wu and Storey, 2016, Balakrishnan et al., 2015, Chen et al., 2015, Kim et al., 2015, Nässel et al., 2015, Spellberg and Marr, 2015, Tokusumi et al., 2015, Alic et al., 2014, Bülow et al., 2014, Metaxakis et al., 2014, Ostojic et al., 2014, Varma et al., 2014, Buescher et al., 2013, Hada et al., 2013, Hur et al., 2013, Hwang et al., 2013, Kannan and Fridell, 2013, Kwak et al., 2013, Neckameyer and Argue, 2013, Parisi et al., 2013, Rera et al., 2013, Shim et al., 2013, Sim and Denlinger, 2013, Ahn et al., 2012, Banerjee et al., 2012, Eleftherianos and Castillo, 2012, Hong et al., 2012, Iliadi et al., 2012, Jin et al., 2012, Kuo et al., 2012, Lee et al., 2012, Rera et al., 2012, Tokusumi et al., 2012, Alic et al., 2011, Gáliková et al., 2011, Nishimura et al., 2011, Partridge et al., 2011, Rajan and Perrimon, 2011, Sharma et al., 2011, Slack et al., 2011, Wang et al., 2011, Wigby et al., 2011, Bülow et al., 2010, Chung et al., 2010, Hwang et al., 2010, Tiefenböck et al., 2010, Hong et al., 2009, Ikeya et al., 2009, Lee et al., 2009, Mojsilovic-Petrovic et al., 2009, Zid et al., 2009, Giannakou et al., 2008, Hansen and Pletcher, 2008, Hsu et al., 2008, Lee et al., 2008, Stieper et al., 2008, Vihervaara and Puig, 2008, Villa-Cuesta et al., 2008, Yu et al., 2008, Casas-Tinto et al., 2007, Giannakou et al., 2007, Hoshizaki and Gibbs, 2007, Lasko and Sonenberg, 2007, Marr et al., 2007, Min et al., 2007, Tountas and Fortini, 2007, Xue et al., 2007, Betschinger et al., 2006, Herranz et al., 2006, Liu and Lehmann, 2006, Liu and Lehmann, 2006, Luong et al., 2006, Takacs-Vellai, 2006, Brandt et al., 2005, Colombani et al., 2005, Colombani et al., 2005, Flatt et al., 2005, Giannakou et al., 2005, Giannakou et al., 2005, Kenyon C., 2005, King-Jones and Thummel, 2005, Orme and Leevers, 2005, Partridge et al., 2005, Puig and Tjian, 2005, Shingleton, 2005, Shingleton et al., 2005, Tatar, 2005, Tettweiler, 2005, Tettweiler et al., 2005, van der Heide and Smidt, 2005, Wittwer et al., 2005, Giannakou et al., 2004, Hwangbo et al., 2004, Junger et al., 2004, Tatar et al., 2004, Wessells et al., 2004, Junger et al., 2003, Kramer et al., 2003, Lochhead et al., 2003, Puig et al., 2003)
foxo
(Birnbaum et al., 2019, Chandran et al., 2019, Dreyer and Shingleton, 2019, Gumeni et al., 2019, Huang et al., 2019, Molaei et al., 2019, Pahl et al., 2019, Robles-Murguia et al., 2019, Shokri et al., 2019, Westfall et al., 2019, Zheng, 2019.3.1, Bischof et al., 2018, Gáliková and Klepsatel, 2018, Ghiglione et al., 2018, Lin et al., 2018, Sharma et al., 2018, Singh and Chowdhuri, 2018, Takahashi et al., 2018, Tsai et al., 2018, Hoedjes et al., 2017, Kang et al., 2017, Pamudurti et al., 2017, Transgenic RNAi Project members, 2017-, Tsakiri et al., 2017, Clandinin and Owens, 2016-, Dobson et al., 2016, Fink et al., 2016, Gruntenko et al., 2016, Kakanj et al., 2016, Kuleesha et al., 2016, Palu and Thummel, 2016, Schwartz et al., 2016, Sieber et al., 2016, Slade and Staveley, 2016, Vinayagam et al., 2016, Calap-Quintana et al., 2015, Gene Disruption Project members, 2015-, Mensah et al., 2015, Schertel et al., 2015, Slade and Staveley, 2015, Sopko et al., 2015, Tower, 2015, Xing et al., 2015, Zhang et al., 2015, Ashwal-Fluss et al., 2014, Das et al., 2014, Ghosh et al., 2014, Guo et al., 2014, Horiguchi et al., 2014, Ikmi et al., 2014, Bai et al., 2013, Iyer et al., 2013, Karpac et al., 2013, Partridge, 2013.2.12, Soh et al., 2013, Sopko and Perrimon, 2013, Tixier et al., 2013, Tixier et al., 2013, Yang et al., 2013, Aoki et al., 2012, Iliadi et al., 2012, Kuo et al., 2012, Papatheodorou et al., 2012, Rynes et al., 2012, Spokony and White, 2012.5.22, Wang et al., 2012, Carreira et al., 2011, Cognigni et al., 2011, Glatter et al., 2011, Grimberg et al., 2011, Karpac et al., 2011, Sinenko et al., 2011, Sousa-Nunes et al., 2011, Tang et al., 2011, Tatar, 2011, Tuxworth et al., 2011, Xiang et al., 2011, Yamamoto and Tatar, 2011, Ables and Drummond-Barbosa, 2010, Becker et al., 2010, Carvalho et al., 2010, Demontis and Perrimon, 2010, Heublein et al., 2010, Kockel et al., 2010, Kühnlein, 2010, LaFever et al., 2010, Magwire et al., 2010, Siegrist et al., 2010, Alvarez-Ponce et al., 2009, Carreira et al., 2009, Demontis and Perrimon, 2009, Diangelo and Birnbaum, 2009, Kent et al., 2009, Mattila et al., 2009, Mojsilovic-Petrovic et al., 2009, Read et al., 2009, Song et al., 2009, Tsubouchi et al., 2009, Zid et al., 2009, Griswold et al., 2008, Khokhar et al., 2008, Kramer et al., 2008, Mensch et al., 2008, Wang et al., 2008, Zhao et al., 2008, Adryan et al., 2007, Minidorff et al., 2007, Minidorff et al., 2007, Slade et al., 2007, Zheng et al., 2007, Dionne et al., 2006, Edgar, 2006, Koh et al., 2006, Lazzaro and Galac, 2006, Puig, 2006.4.24, Rollmann et al., 2006, Goberdhan et al., 2005, Teleman et al., 2005)
Name Synonyms
Forkhead Box O
Forkhead bOX-containing protein, subfamily O
Forkhead box
Forkhead box type O
forkhead box sub-group O
forkhead box, subgroup O
forkhead box-containing protein, O subfamily
forkhead boxO transcription factor
forkhead transcription factor
Secondary FlyBase IDs
  • FBgn0062059
Datasets (1)
Study focus (1)
Experimental Role
Project
Project Type
Title
  • bait_protein
Interaction map generated by purification of insulin pathway factors, with identification of copurifying proteins by mass spectrometry.
References (555)