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Gene Dmel\HtrA2

General Information
Symbol	Dmel\HtrA2	Species	D. melanogaster
Name	HtrA2	Annotation symbol	CG8464
Feature type	protein_coding_gene	FlyBase ID	FBgn0038233
Gene Model Status	Current	Stock availability	5 publicly available
Also Known As	Omi, DmHtrA2, dOmi
Genomic Location
Chromosome (arm)	3R	Recombination map
Cytogenetic map	88C3-88C3	Sequence location	3R:10,335,616..10,337,414 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene HtrA2 is referred to in FlyBase by the symbol Dmel\HtrA2 (CG8464, FBgn0038233). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: peptidase activity. There is experimental evidence that it is involved in the biological process: mitochondrion organization. 9 alleles are reported. The phenotypes of these alleles are annotated with: eye; spermatozoon. It has one annotated transcript and one annotated polypeptide. Protein features are: PDZ/DHR/GLGF; Peptidase S1/S6, chymotrypsin/Hap; Peptidase S1C, HrtA/DegP2/Q/S; Peptidase cysteine/serine, trypsin-like. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression. Peak expression observed within 00-06 hour embryonic stages, at stages throughout the pupal period, in adult male stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult testis. Comments on Affy2 ProbeSet: ProbeSet 1625928_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of HtrA2. Gene sequence location is 3R:10335616..10337414.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2012_01	References Holland et al., 2011, Genetics 188(2): 359--367 Sequence features BKN22437 HFA16425
FB2011_10
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 88C3-88C3   Limits computationally determined from genome sequence between P{PZ}cv-c06951 and P{PZ}put10460
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\HtrA2 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) HtrA2-RA FBtr0082987  NM_142109   1647   422
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein HtrA2-PA   FBpp0082446   46.0   422   10.00     NP_650366   AAF55062
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Peptidase S1/S6, chymotrypsin/Hap (IPR001254) PDZ/DHR/GLGF (IPR001478) Peptidase S1C, HrtA/DegP2/Q/S (IPR001940) Peptidase cysteine/serine, trypsin-like (IPR009003)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014297 AAF55062   AB112473 BAE72064   AI260427   AY075206 AAL68074   BF496364   BF499650   BF500387   CZ466307   EC206676
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9VFJ3
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0038233    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0038233 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression. Peak expression observed within 00-06 hour embryonic stages, at stages throughout the pupal period, in adult male stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0038233 expression level Developmental Stage   Expression Level embryo 00-02hr    1515 embryo 02-04hr    2103 embryo 04-06hr    2298 embryo 06-08hr    1236 embryo 08-10hr    1067 embryo 10-12hr    842 embryo 12-14hr    655 embryo 14-16hr    610 embryo 16-18hr    587 embryo 18-20hr    507 embryo 20-22hr    437 embryo 22-24hr    441 larva L1    415 larva L2    497 larva L3 12hr old    418 larva L3 puffstage 1-2    467 larva L3 puffstage 3-6    948 larva L3 puffstage 7-9    979 white prepupae new    965 white prepupae 12hr    1217 white prepupae 24hr    1504 pupae 2d postWPP    1703 pupae 3d postWPP    1769 pupae 4d postWPP    1464 adult male 01day    2129 adult male 05day    2800 adult male 30day    2506 adult female 01day    746 adult female 05day    931 adult female 30day    959 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (1515) embryo 02-04hr  (2103) embryo 04-06hr  (2298) embryo 06-08hr  (1236) embryo 08-10hr  (1067) embryo 10-12hr  (842) embryo 12-14hr  (655) embryo 14-16hr  (610) embryo 16-18hr  (587) embryo 18-20hr  (507) embryo 20-22hr  (437) embryo 22-24hr  (441) larva L1  (415) larva L2  (497) larva L3 12hr old  (418) larva L3 puffstage 1-2  (467) larva L3 puffstage 3-6  (948) larva L3 puffstage 7-9  (979) white prepupae new  (965) white prepupae 12hr  (1217) white prepupae 24hr  (1504) pupae 2d postWPP  (1703) pupae 3d postWPP  (1769) pupae 4d postWPP  (1464) adult male 01day  (2129) adult male 05day  (2800) adult male 30day  (2506) adult female 01day  (746) adult female 05day  (931) adult female 30day  (959) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (1515) embryo 02-04hr  (2103) embryo 04-06hr  (2298) embryo 06-08hr    1236 embryo 08-10hr    1067 embryo 10-12hr    842 embryo 12-14hr    655 embryo 14-16hr    610 embryo 16-18hr    587 embryo 18-20hr    507 embryo 20-22hr    437 embryo 22-24hr    441 larva L1    415 larva L2    497 larva L3 12hr old    418 larva L3 puffstage 1-2    467 larva L3 puffstage 3-6    948 larva L3 puffstage 7-9    979 white prepupae new    965 white prepupae 12hr    1217 white prepupae 24hr  1504 pupae 2d postWPP  (1703) pupae 3d postWPP  (1769) pupae 4d postWPP  1464 adult male 01day  (2129) adult male 05day  (2800) adult male 30day  (2506) adult female 01day    746 adult female 05day    931 adult female 30day    959 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    1515 embryo 02-04hr    2103 embryo 04-06hr    2298 embryo 06-08hr    1236 embryo 08-10hr    1067 embryo 10-12hr    842 embryo 12-14hr    655 embryo 14-16hr    610 embryo 16-18hr    587 embryo 18-20hr    507 embryo 20-22hr    437 embryo 22-24hr    441 larva L1    415 larva L2    497 larva L3 12hr old    418 larva L3 puffstage 1-2    467 larva L3 puffstage 3-6    948 larva L3 puffstage 7-9    979 white prepupae new    965 white prepupae 12hr    1217 white prepupae 24hr    1504 pupae 2d postWPP    1703 pupae 3d postWPP    1769 pupae 4d postWPP    1464 adult male 01day    2129 adult male 05day    2800 adult male 30day    2506 adult female 01day    746 adult female 05day    931 adult female 30day    959 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    1515 embryo 02-04hr    2103 embryo 04-06hr    2298 embryo 06-08hr    1236 embryo 08-10hr    1067 embryo 10-12hr    842 embryo 12-14hr    655 embryo 14-16hr    610 embryo 16-18hr    587 embryo 18-20hr    507 embryo 20-22hr    437 embryo 22-24hr    441 larva L1    415 larva L2    497 larva L3 12hr old    418 larva L3 puffstage 1-2    467 larva L3 puffstage 3-6    948 larva L3 puffstage 7-9    979 white prepupae new    965 white prepupae 12hr    1217 white prepupae 24hr    1504 pupae 2d postWPP    1703 pupae 3d postWPP    1769 pupae 4d postWPP    1464 adult male 01day    2129 adult male 05day    2800 adult male 30day    2506 adult female 01day    746 adult female 05day    931 adult female 30day    959 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0038233 expression level Developmental Stage   Expression Level embryo 00-02hr    1515 embryo 02-04hr    2103 embryo 04-06hr    2298 embryo 06-08hr    1236 embryo 08-10hr    1067 embryo 10-12hr    842 embryo 12-14hr    655 embryo 14-16hr    610 embryo 16-18hr    587 embryo 18-20hr    507 embryo 20-22hr    437 embryo 22-24hr    441 larva L1    415 larva L2    497 larva L3 12hr old    418 larva L3 puffstage 1-2    467 larva L3 puffstage 3-6    948 larva L3 puffstage 7-9    979 white prepupae new    965 white prepupae 12hr    1217 white prepupae 24hr    1504 pupae 2d postWPP    1703 pupae 3d postWPP    1769 pupae 4d postWPP    1464 adult male 01day    2129 adult male 05day    2800 adult male 30day    2506 adult female 01day    746 adult female 05day    931 adult female 30day    959 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (1515) embryo 02-04hr  (2103) embryo 04-06hr  (2298) embryo 06-08hr  (1236) embryo 08-10hr  (1067) embryo 10-12hr  (842) embryo 12-14hr  (655) embryo 14-16hr  (610) embryo 16-18hr  (587) embryo 18-20hr  (507) embryo 20-22hr  (437) embryo 22-24hr  (441) larva L1  (415) larva L2  (497) larva L3 12hr old  (418) larva L3 puffstage 1-2  (467) larva L3 puffstage 3-6  (948) larva L3 puffstage 7-9  (979) white prepupae new  (965) white prepupae 12hr  (1217) white prepupae 24hr  (1504) pupae 2d postWPP  (1703) pupae 3d postWPP  (1769) pupae 4d postWPP  (1464) adult male 01day  (2129) adult male 05day  (2800) adult male 30day  (2506) adult female 01day  (746) adult female 05day  (931) adult female 30day  (959) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  1515 embryo 02-04hr  2103 embryo 04-06hr  2298 embryo 06-08hr    1236 embryo 08-10hr    1067 embryo 10-12hr    842 embryo 12-14hr    655 embryo 14-16hr    610 embryo 16-18hr    587 embryo 18-20hr    507 embryo 20-22hr    437 embryo 22-24hr    441 larva L1    415 larva L2    497 larva L3 12hr old    418 larva L3 puffstage 1-2    467 larva L3 puffstage 3-6    948 larva L3 puffstage 7-9    979 white prepupae new    965 white prepupae 12hr    1217 white prepupae 24hr  1504 pupae 2d postWPP  1703 pupae 3d postWPP  1769 pupae 4d postWPP  1464 adult male 01day  2129 adult male 05day  (2800) adult male 30day  (2506) adult female 01day    746 adult female 05day    931 adult female 30day    959 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    1515 embryo 02-04hr    2103 embryo 04-06hr    2298 embryo 06-08hr    1236 embryo 08-10hr    1067 embryo 10-12hr    842 embryo 12-14hr    655 embryo 14-16hr    610 embryo 16-18hr    587 embryo 18-20hr    507 embryo 20-22hr    437 embryo 22-24hr    441 larva L1    415 larva L2    497 larva L3 12hr old    418 larva L3 puffstage 1-2    467 larva L3 puffstage 3-6    948 larva L3 puffstage 7-9    979 white prepupae new    965 white prepupae 12hr    1217 white prepupae 24hr    1504 pupae 2d postWPP    1703 pupae 3d postWPP    1769 pupae 4d postWPP    1464 adult male 01day    2129 adult male 05day    2800 adult male 30day    2506 adult female 01day    746 adult female 05day    931 adult female 30day    959 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    1515 embryo 02-04hr    2103 embryo 04-06hr    2298 embryo 06-08hr    1236 embryo 08-10hr    1067 embryo 10-12hr    842 embryo 12-14hr    655 embryo 14-16hr    610 embryo 16-18hr    587 embryo 18-20hr    507 embryo 20-22hr    437 embryo 22-24hr    441 larva L1    415 larva L2    497 larva L3 12hr old    418 larva L3 puffstage 1-2    467 larva L3 puffstage 3-6    948 larva L3 puffstage 7-9    979 white prepupae new    965 white prepupae 12hr    1217 white prepupae 24hr    1504 pupae 2d postWPP    1703 pupae 3d postWPP    1769 pupae 4d postWPP    1464 adult male 01day    2129 adult male 05day    2800 adult male 30day    2506 adult female 01day    746 adult female 05day    931 adult female 30day    959 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0038233    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0038233 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult testis. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0038233 expression level Tissue   Expression Level Larval Central Nervous System    25.1 Larval Midgut    27 Larval Hindgut    28.3 Larval Malpighian Tubules    28.7 Larval Fat Body    88.2 Larval Salivary Gland no informative data Larval Trachea    13.55 Larval Carcass    26.85 Adult Head    33.9 Adult Eye    16.125 Adult Brain    32.7 Adult Thoracic-Abdominal Ganglion    33.4 Adult Crop    36.9 Adult Midgut    36.9 Adult Hindgut    43.4 Adult Malpighian Tubules no informative data Adult Fat Body    32.5 Adult Salivary Gland    72.8 Adult Heart    16.65 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca    19.7 Adult Ovary    60.3 Adult Testis    459.9 Adult Male Accessory Gland    24 Adult Carcass    46.8 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    25.1 Larval Midgut    27 Larval Hindgut    28.3 Larval Malpighian Tubules    28.7 Larval Fat Body    88.2 Larval Salivary Gland no informative data Larval Trachea    13.55 Larval Carcass    26.85 Adult Head    33.9 Adult Eye    16.125 Adult Brain    32.7 Adult Thoracic-Abdominal Ganglion    33.4 Adult Crop    36.9 Adult Midgut    36.9 Adult Hindgut    43.4 Adult Malpighian Tubules no informative data Adult Fat Body    32.5 Adult Salivary Gland    72.8 Adult Heart    16.65 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca    19.7 Adult Ovary    60.3 Adult Testis    459.9 Adult Male Accessory Gland    24 Adult Carcass    46.8 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    25.1 Larval Midgut    27 Larval Hindgut    28.3 Larval Malpighian Tubules    28.7 Larval Fat Body    88.2 Larval Salivary Gland no informative data Larval Trachea    13.55 Larval Carcass    26.85 Adult Head    33.9 Adult Eye    16.125 Adult Brain    32.7 Adult Thoracic-Abdominal Ganglion    33.4 Adult Crop    36.9 Adult Midgut    36.9 Adult Hindgut    43.4 Adult Malpighian Tubules no informative data Adult Fat Body    32.5 Adult Salivary Gland    72.8 Adult Heart    16.65 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca    19.7 Adult Ovary    60.3 Adult Testis    459.9 Adult Male Accessory Gland    24 Adult Carcass    46.8 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    25.1 Larval Midgut    27 Larval Hindgut    28.3 Larval Malpighian Tubules    28.7 Larval Fat Body    88.2 Larval Salivary Gland no informative data Larval Trachea    13.55 Larval Carcass    26.85 Adult Head    33.9 Adult Eye    16.125 Adult Brain    32.7 Adult Thoracic-Abdominal Ganglion    33.4 Adult Crop    36.9 Adult Midgut    36.9 Adult Hindgut    43.4 Adult Malpighian Tubules no informative data Adult Fat Body    32.5 Adult Salivary Gland    72.8 Adult Heart    16.65 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca    19.7 Adult Ovary    60.3 Adult Testis    459.9 Adult Male Accessory Gland    24 Adult Carcass    46.8 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0038233 expression level Tissue   Expression Level Larval Central Nervous System    25.1 Larval Midgut    27 Larval Hindgut    28.3 Larval Malpighian Tubules    28.7 Larval Fat Body    88.2 Larval Salivary Gland no informative data Larval Trachea    13.55 Larval Carcass    26.85 Adult Head    33.9 Adult Eye    16.125 Adult Brain    32.7 Adult Thoracic-Abdominal Ganglion    33.4 Adult Crop    36.9 Adult Midgut    36.9 Adult Hindgut    43.4 Adult Malpighian Tubules no informative data Adult Fat Body    32.5 Adult Salivary Gland    72.8 Adult Heart    16.65 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca    19.7 Adult Ovary    60.3 Adult Testis    459.9 Adult Male Accessory Gland    24 Adult Carcass    46.8 Expression Level Scale  None   Low   Moderate   High  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    25.1 Larval Midgut    27 Larval Hindgut    28.3 Larval Malpighian Tubules    28.7 Larval Fat Body    88.2 Larval Salivary Gland no informative data Larval Trachea    13.55 Larval Carcass    26.85 Adult Head    33.9 Adult Eye    16.125 Adult Brain    32.7 Adult Thoracic-Abdominal Ganglion    33.4 Adult Crop    36.9 Adult Midgut    36.9 Adult Hindgut    43.4 Adult Malpighian Tubules no informative data Adult Fat Body    32.5 Adult Salivary Gland    72.8 Adult Heart    16.65 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca    19.7 Adult Ovary    60.3 Adult Testis    459.9 Adult Male Accessory Gland    24 Adult Carcass    46.8 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    25.1 Larval Midgut    27 Larval Hindgut    28.3 Larval Malpighian Tubules    28.7 Larval Fat Body    88.2 Larval Salivary Gland no informative data Larval Trachea    13.55 Larval Carcass    26.85 Adult Head    33.9 Adult Eye    16.125 Adult Brain    32.7 Adult Thoracic-Abdominal Ganglion    33.4 Adult Crop    36.9 Adult Midgut    36.9 Adult Hindgut    43.4 Adult Malpighian Tubules no informative data Adult Fat Body    32.5 Adult Salivary Gland    72.8 Adult Heart    16.65 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca    19.7 Adult Ovary    60.3 Adult Testis    459.9 Adult Male Accessory Gland    24 Adult Carcass    46.8 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    25.1 Larval Midgut    27 Larval Hindgut    28.3 Larval Malpighian Tubules    28.7 Larval Fat Body    88.2 Larval Salivary Gland no informative data Larval Trachea    13.55 Larval Carcass    26.85 Adult Head    33.9 Adult Eye    16.125 Adult Brain    32.7 Adult Thoracic-Abdominal Ganglion    33.4 Adult Crop    36.9 Adult Midgut    36.9 Adult Hindgut    43.4 Adult Malpighian Tubules no informative data Adult Fat Body    32.5 Adult Salivary Gland    72.8 Adult Heart    16.65 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca    19.7 Adult Ovary    60.3 Adult Testis    459.9 Adult Male Accessory Gland    24 Adult Carcass    46.8 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland no informative data Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules no informative data Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    33.9   NA  Eye    16.125   NA  Brain    32.7   25.1  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    33.4   NA  Crop    36.9   27  Midgut    36.9   28.3  Hindgut    43.4   28.7  Malpighian Tubules    no informative data   88.2  Fat Body    32.5   no informative data  Salivary Gland    72.8   NA  Heart    16.65   13.55  Trachea    NA   NA  VirginFemale Spermatheca    no informative data   NA  InseminatedFemale Spermatheca    19.7   NA  Ovary    60.3   NA  Testis    459.9   NA  Male Accessory Gland    24   26.85  Carcass    46.8 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_21
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0038233 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG8464-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for HtrA2 Stages(s) 1-3 Stages(s) 7-8 Stages(s) 9-10 Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable, with Scer\GAL4pnr-MD237 HtrA2GD13932 Sterility Allele female fertile HtrA2Δ1 male sterile HtrA2Δ1 Other Phenotypes Allele chemical sensitive HtrA2Δ1 flightless HtrA2Δ1 locomotor behavior defective HtrA2Δ1 short lived HtrA2Δ1 visible HtrA2ΔPDZ.GMR visible | heat sensitive HtrA2GMR.PK Phenotype manifest in Allele eye HtrA2ΔPDZ.GMR eye | heat sensitive HtrA2GMR.PK mitochondrion & indirect flight muscle HtrA2Δ1 spermatozoon HtrA2Δ1
Classical Alleles ( 3 )
For All Classical Alleles Show
Allele of HtrA2 Class Mutagen Stocks Known lesion HtrA2f03785 piggyBac transposase 2 -- HtrA2c00240 piggyBac transposase 0 -- HtrA2Δ1 P-element activity 0 Yes
Alleles Carried on Transgenic Constructs ( 6 )
For All Alleles Carried on Transgenic Constructs Show
Allele of HtrA2 Class Mutagen Stocks Known lesion HtrA2GD13932 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes HtrA2HM05030 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes HtrA2+t2.5 in vitro construct - genomic fragment 0 Yes HtrA2GMR.PK in vitro construct - regulatory fusion 0 Yes HtrA2Scer\UAS.P\T.cTa in vitro construct - regulatory fusion 0 Yes HtrA2ΔPDZ.GMR in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Partially disrupted in	Df(3R)HtrA2Δ1 (Tain et al., 2009)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD13932} NA P{TRiP.HM05030} NA P{UASp-HtrA2.T} NA characterization construct P{GMR-HtrA2.K} NA P{GMR-HtrA2.ΔPDZ} NA P{HtrA2+t2.5} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions PBac{PB}HtrA2c00240 NA PBac{WH}HtrA2f03785 NA insertion of mobile activating element P{EP}mRpL11G4907 NA
Gene Ontology: Function, Process & Cellular Component ( 5 unique terms )
Terms Based on Experimental Evidence ( 3 terms )
Molecular Function
CV term Evidence References
peptidase activity inferred from direct assay (Tain et al., 2009, Khan et al., 2008)
Biological Process
CV term Evidence References
mitochondrion organization inferred from mutant phenotype (Tain et al., 2009)
Cellular Component
CV term Evidence References
mitochondrion inferred from direct assay (Khan et al., 2008)
Terms Based on Predictions or Assertions ( 2 terms )
Molecular Function
CV term Evidence References
serine-type endopeptidase activity inferred from electronic annotation with InterPro:IPR001254, InterPro:IPR001940 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
proteolysis inferred from electronic annotation with InterPro:IPR001254, InterPro:IPR001940 (FlyBase Curators et al., 2004-)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions HtrA2 allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 66831 DroID - A comprehensive database of gene and protein interactions. • FBgn0038233 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 41756
Orthologs
Genome-wide drosophilid orthologs	Dana\GF17480 Dere\GG21285 Dgri\GH13631 Dmoj\GI24802 Dper\GL24014 Dpse\GA21097 Dsec\GM25850 Dsim\GD20417 Dvir\GJ24448 Dwil\GK12147 Dyak\GE26447
Curated drosophilid orthologs	Dpse\GA21097
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL006373-PB Aedes aegypti (mosquito) AGAP000240-PA Anopheles gambiae (mosquito) XP_624354.1 Apis mellifera (honey bee) At5g27660.1 Arabidopsis thaliana (wall cress) 24209 Batrachochytrium dendrobatidis (chytrid fungus) 124691 Branchiostoma floridae (lancelet) 240343 Branchiostoma floridae (lancelet) BGIBMGA002318-PA Bombyx mori (silk worm) ENSBTAP00000026804 Bos taurus (bovine) ENSCAFP00000012325 Canis familiaris (dog) ENSCINP00000020849 Ciona intestinalis (sea squirt) CMD006C Cyanidioschyzon merolae (red alga) CPIJ005160 Culex pipens (mosquito) ENSCPOP00000011455 Cavia porcellus (guinea pig) 126221 Chlamidomonas reinhardtii (green alga) ENSCSAVP00000012890 Ciona savignyi (sedentary tunicate) 93602 Capitella spl (polychaete worm) DDB0204001 Dictyostelium discoideum (amoeba) ENSDARP00000092827 Danio rerio (zebra fish) ENSECAP00000000520 Equus caballus (horse) NP_414703.1 Escherichia coli K12 (bacteria) ENSGACP00000011279 Gymnopilus aculeatus (mushroom) ENSGALP00000015520 Gallus gallus (chicken) 82139 Hypsipyla robusta (cedar shoot borer) ENSP00000258080 Homo sapiens (human) ENSMODP00000005932 Monodelphis domestica (gray opossum) ENSMMUP00000002846 Macaca mulatta (rhesus monkey) ENSMUSP00000087073 Mus musculus (house mouse) 22575 Nematostella vectensis (starlet anemone) XP_001606558.1 Nasonia vitripennis (wasp) ENSOANP00000014343 Ornithorynchus anatinus (platypus) ENSORLP00000019645 Oryzias latipes (japanese killifish) LOC_Os11g14170.1 Oryza sativa (asian rice) 3491 Ostreococcus tauri (green alga) MAL8P1.98 Plasmodium falciparum (protozoal parasite) PHUM010695-PA Pediculus humanus (human body louse) 141625 Physcomitrella patens (moss) ENSPPYP00000013676 Pongo pygmaeus (orangutan) 95999 Phytophthora ramorum (sudden oak death pathogen) 157071 Phytophthora sojae (root rot pathogen) 792125 Populus trichocarpa (black cottonwood) ENSPTRP00000020762 Pan troglodytes (chimpanzee) ENSRNOP00000030076 Rattus norvegicus (norway rat) 5056476 Sorghum bicolor (sorghum) XP_001195779.1 Strongylocentrotus purpuratus (purple sea urchin) XP_001197113.1 Strongylocentrotus purpuratus (purple sea urchin) 58565 Trichoplax adhaerens (metazoa) XP_968662.2 Tribolium castaneum (red flour beetle) ENSTNIP00000020475 Tetraodon nigroviridis (green spotted pufferfish) 34684 Thalassiosira pseudonana (marine diatom) ENSTRUP00000031408 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000033992 Xenopus tropicalis (frog) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV11522 LH18248 ISCW020167 FBgn0243468 FBgn0214158 FBgn0211528 FBgn0191889 FBgn0180706 FBgn0081085 FBgn0161604 FBgn0147524 FBgn0121107 FBgn0113464 FBgn0094498 CPIJ005160 CPIJ019291 BGIBMGA002318 GB16003 AGAP000240 AAEL006373 PB25368 PHUM529710 GLEAN_03010
Stocks & Reagents
Stocks Listed in FlyBase ( 5 )
Bloomington	28544 y1 v1; P{TRiP.HM05030}attP2 18692 w1118; PBac{WH}HtrA2f03785/TM6B, Tb1
Harvard	- PBac{WH}HtrA2f03785
VDRC	v24104 w1118; P{GD13932}v24104 v24106 w1118; P{GD13932}v24106
Genomic Clones ( 1 )
	BACR04O02 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 5 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	AT14262
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT10143 AT15260 LP04293
Other clones	CK01.43D.H7
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0038233 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 41756
Antibody Information
	polyclonal (Khan et al., 2008)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: HtrA2 CG8464 (Igaki et al., 2003.6.16)
Source for database merge of
Additional comments
Other Comments
	dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology. (Kiger et al., 2003)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_142109 RefSeq (Proteins) • NP_650366 DDBJ / EMBL / GenBank • AAF55062 AAL68074 AB112473 AY075206 BAE72064 BF499650 CZ466307 Entrez Gene - A searchable database of RefSeq genes. • 41756 UniProtKB/TrEMBL • Q9VFJ3
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Peptidase S1/S6, chymotrypsin/Hap (IPR001254) PDZ/DHR/GLGF (IPR001478) Peptidase S1C, HrtA/DegP2/Q/S (IPR001940) Peptidase cysteine/serine, trypsin-like (IPR009003)
Linkouts
	BioGRID - A database of protein and genetic interactions • 66831 DroID - A comprehensive database of gene and protein interactions. • FBgn0038233 DRSC - Results from RNAi screens. • FBgn0038233 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0038233 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG8464-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0038233 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 41756 InParanoid A subset of ortholog calls from InParanoid. • AAEL006373-PB Aedes aegypti (mosquito) AGAP000240-PA Anopheles gambiae (mosquito) XP_624354.1 Apis mellifera (honey bee) At5g27660.1 Arabidopsis thaliana (wall cress) 24209 Batrachochytrium dendrobatidis (chytrid fungus) 124691 Branchiostoma floridae (lancelet) 240343 Branchiostoma floridae (lancelet) BGIBMGA002318-PA Bombyx mori (silk worm) ENSBTAP00000026804 Bos taurus (bovine) ENSCAFP00000012325 Canis familiaris (dog) ENSCINP00000020849 Ciona intestinalis (sea squirt) CMD006C Cyanidioschyzon merolae (red alga) CPIJ005160 Culex pipens (mosquito) ENSCPOP00000011455 Cavia porcellus (guinea pig) 126221 Chlamidomonas reinhardtii (green alga) ENSCSAVP00000012890 Ciona savignyi (sedentary tunicate) 93602 Capitella spl (polychaete worm) DDB0204001 Dictyostelium discoideum (amoeba) ENSDARP00000092827 Danio rerio (zebra fish) ENSECAP00000000520 Equus caballus (horse) NP_414703.1 Escherichia coli K12 (bacteria) ENSGACP00000011279 Gymnopilus aculeatus (mushroom) ENSGALP00000015520 Gallus gallus (chicken) 82139 Hypsipyla robusta (cedar shoot borer) ENSP00000258080 Homo sapiens (human) ENSMODP00000005932 Monodelphis domestica (gray opossum) ENSMMUP00000002846 Macaca mulatta (rhesus monkey) ENSMUSP00000087073 Mus musculus (house mouse) 22575 Nematostella vectensis (starlet anemone) XP_001606558.1 Nasonia vitripennis (wasp) ENSOANP00000014343 Ornithorynchus anatinus (platypus) ENSORLP00000019645 Oryzias latipes (japanese killifish) LOC_Os11g14170.1 Oryza sativa (asian rice) 3491 Ostreococcus tauri (green alga) MAL8P1.98 Plasmodium falciparum (protozoal parasite) PHUM010695-PA Pediculus humanus (human body louse) 141625 Physcomitrella patens (moss) ENSPPYP00000013676 Pongo pygmaeus (orangutan) 95999 Phytophthora ramorum (sudden oak death pathogen) 157071 Phytophthora sojae (root rot pathogen) 792125 Populus trichocarpa (black cottonwood) ENSPTRP00000020762 Pan troglodytes (chimpanzee) ENSRNOP00000030076 Rattus norvegicus (norway rat) 5056476 Sorghum bicolor (sorghum) XP_001195779.1 Strongylocentrotus purpuratus (purple sea urchin) XP_001197113.1 Strongylocentrotus purpuratus (purple sea urchin) 58565 Trichoplax adhaerens (metazoa) XP_968662.2 Tribolium castaneum (red flour beetle) ENSTNIP00000020475 Tetraodon nigroviridis (green spotted pufferfish) 34684 Thalassiosira pseudonana (marine diatom) ENSTRUP00000031408 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000033992 Xenopus tropicalis (frog) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 41756 modMine - Data generated by the modENCODE project. • FBgn0038233 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV11522 LH18248 ISCW020167 FBgn0243468 FBgn0214158 FBgn0211528 FBgn0191889 FBgn0180706 FBgn0081085 FBgn0161604 FBgn0147524 FBgn0121107 FBgn0113464 FBgn0094498 CPIJ005160 CPIJ019291 BGIBMGA002318 GB16003 AGAP000240 AAEL006373 PB25368 PHUM529710 GLEAN_03010
Synonyms & Secondary IDs ( 9 )
Reported As
Symbol Synonym	CG8464 (Giot et al., 2003, Challa et al., 2007, Tain et al., 2009, Perkins et al., 2009, Khan et al., 2008, Tomancak et al., 2007) DmHtrA2 (Igaki et al., 2003.6.16, Igaki et al., 2007) dOmi (Challa et al., 2007, Khan et al., 2008) domi (Challa et al., 2007) HtrA2 (Whitworth et al., 2008, Yun et al., 2008, Khan et al., 2008, Tain et al., 2009) htrA2 (Whitworth et al., 2008) HtrA2/Omi (Biskup, 2006) Omi (Whitworth et al., 2008, Yun et al., 2008) omi (Whitworth et al., 2008)
Name Synonym	HtrA2
Secondary FlyBase IDs
References ( 23 )
Generate a list of	All references relating to this gene ( 23 )
List References by type	Research paper  ( 8 ) Supplementary material  ( 4 ) Review  ( 1 ) Personal communication to FlyBase  ( 4 ) Abstract  ( 1 ) FlyBase analysis  ( 1 ) DNA/RNA sequence record  ( 1 ) Computer file  ( 3 )
Recent research papers ( 1 )
	Holland et al., 2011, Genetics 188(2): 359--367 A Link Between Impaired Purine Nucleotide Synthesis and Apoptosis in Drosophila melanogaster. [FBrf0213875] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...