Sra-1, Sra1, dSra, DSra-1, PIR121
Gene model reviewed during 5.47
There is only one protein coding transcript and one polypeptide associated with this gene
Interacts with Fmr1 and Rac1. Component of the WAVE complex composed of Hem/Kette, Scar/Wave and Sra-1/Cyfip where it binds through its C-terminus directly to Hem.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Cyfip using the Feature Mapper tool.
Cyfip protein is detected at very low levels in early embryos and then at higher levels at later embryonic stages on western blots. It is observed in the gut and CNS but persists longer in the CNS. It accumulates in CNS axons along commissures and longitudinal connectives. It is present in neuromuscular junctions in stage 17 embryos.
GBrowse - Visual display of RNA-Seq signalsView Dmel\Cyfip in GBrowse 2
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
S2 cells treated with dsRNA generated against this gene show reduced phagocytosis of Candida albicans compared to untreated cells.
dsRNA made from templates generated with primers directed against this gene is tested in an RNAi screen for effects on actin-based lamella formation.