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Gene Dmel\Sra-1

General Information
Symbol	Dmel\Sra-1	Species	D. melanogaster
Name	specifically Rac1-associated protein 1	Annotation symbol	CG4931
Feature type	protein_coding_gene	FlyBase ID	FBgn0038320
Gene Model Status	Current	Stock availability	5 publicly available
Also Known As	CYFIP, sra1, DSra-1
Genomic Location
Chromosome (arm)	3R	Recombination map
Cytogenetic map	88F1-88F1	Sequence location	3R:11,158,988..11,164,087 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene specifically Rac1-associated protein 1 is referred to in FlyBase by the symbol Dmel\Sra-1 (CG4931, FBgn0038320). It is a protein_coding_gene from Drosophila melanogaster. It is reported to have molecular function: Rho GTPase binding. There is experimental evidence that it is involved in the biological process: regulation of cell shape; regulation of synapse organization; axon guidance; cell projection assembly; cortical actin cytoskeleton organization; cell morphogenesis; compound eye morphogenesis; phagocytosis, engulfment. 22 alleles are reported. The phenotypes of these alleles are annotated with: commissure; eye; bouton; intersegmental nerve; embryonic/larval neuromuscular junction; longitudinal connective; microchaeta; ommatidium; synapse; axon. It has one annotated transcript and one annotated polypeptide. Protein features are: Cytoplasmic FMR1-interacting; Cytoplasmic FMR1-interacting, subgroup; Protein of unknown function DUF1394. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-18 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: larval/adult central nervous system, larval/adult midgut, larval hindgut, adult Malpighian tubules, adult heart, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male accessory gland. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, adult crop, adult hindgut, larval Malpighian tubules, larval/adult fat body, virgin spermatheca, adult testis, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1626993_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of Sra-1. Gene sequence location is 3R:11158988..11164087.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 88F1-88F1   Limits computationally determined from genome sequence between P{lacW}MRG15j6A3 and P{PZ}l(3)0653606536
Experimentally Determined Cytological Location
Cytogenetic map Notes References 88E13-88F1     (Langmann, 2001.4.3)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Sra-1 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.47
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Sra-1-RA FBtr0083085  NM_142190   4628   1291
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Sra-1-PA   FBpp0082541   149.3   1291   7.13     NP_650447   AAF55173
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Cytoplasmic FMR1-interacting (IPR008081) Cytoplasmic FMR1-interacting, subgroup (IPR016536) Protein of unknown function DUF1394 (IPR009828)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA439850   AA540491   AA802881   AE014297 AAF55173   AI405710   AI546369   AQ073761   AQ073869   AW942550   AW943936   AY017343 AAG61254   AY029211 AAK31584   AY122203 AAM52715   BI573982   BT011115   BT053748   CL527920   CO153629   CO191205   CO265675   CO269600   CO275341   CO280851   CO290035   CO292050   CO292402   CO297133   CO302511   CO309324   CO315011   CO315582   CO317812   CO322413   CO323547   CO327071   CO331248   CO333292   CO333511   CO336517   CO339960   CO342530   CZ473025   DN153947   DN154121   EC063589   EC064429   EC066402   EC076906   EC078151   EC086510   EC090764   EC199401   EC201812   EC209768   EC209929   EC216701   EC217784   EC223460   EC231893   EC234800   EC246464   EC249997   EC254472   EC258115   EC258380   EC266379   GH748907   GH750302   GH760417   GH761053   GH771799   GH775660   GH783224   GH786661   GH789514   GH795346   GH798592   GH805126   GH829503   GH831319   GH834062   GH837910   GH845177   GH867925   GH867975   GH872059   GH874518   GH874877   GH877694   GH880943   GH893413   GH898974   GH899543   GH899782   GH902182   GH902766   GH904188   GH904495   GH906750   GH923877   GH931641   GH935350
UniProtKB/Swiss-Prot	Q9VF87
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage   presumptive embryonic/larval central nervous system   (Schenck et al., 2004)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization Stage Tissue/Position (including subcellular localization) Reference embryonic stage 14 -- 16   commissure   (Schenck et al., 2004) embryonic stage 14 -- 17   longitudinal connective   (Schenck et al., 2004) western blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage 12 -- 17     (Schenck et al., 2004)   cell   (Schenck et al., 2004) Comment:expression assayed in cultured S2 cells
Additional Descriptive Data
Marker for
	longitudinal connective
Subcellular Localization (GO Cellular Component)
CV term Evidence References
apical part of cell inferred from direct assay (Galy et al., 2011) cytoplasm inferred from direct assay (Galy et al., 2011) SCAR complex inferred from direct assay (assigned by UniProtKB) (Schenck et al., 2004)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: larval/adult central nervous system, larval/adult midgut, larval hindgut, adult Malpighian tubules, adult heart, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male accessory gland. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, adult crop, adult hindgut, larval Malpighian tubules, larval/adult fat body, virgin spermatheca, adult testis, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    933.2 Larval Midgut    565.5 Larval Hindgut    500.6 Larval Malpighian Tubules    491.9 Larval Fat Body    286 Larval Salivary Gland    629.5 Larval Trachea    744.7 Larval Carcass    379.5 Adult Head    434 Adult Eye    377.775 Adult Brain    509 Adult Thoracic-Abdominal Ganglion    607.8 Adult Crop    470.4 Adult Midgut    604.9 Adult Hindgut    487.2 Adult Malpighian Tubules    524.2 Adult Fat Body    286.5 Adult Salivary Gland    807.6 Adult Heart    505.625 Adult VirginFemale Spermatheca    451 Adult InseminatedFemale Spermatheca    545.3 Adult Ovary    611.2 Adult Testis    108.2 Adult Male Accessory Gland    889.1 Adult Carcass    267.3 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (933.2) Larval Midgut  (565.5) Larval Hindgut  500.6 Larval Malpighian Tubules    491.9 Larval Fat Body    286 Larval Salivary Gland  (629.5) Larval Trachea  (744.7) Larval Carcass    379.5 Adult Head    434 Adult Eye    377.775 Adult Brain  509 Adult Thoracic-Abdominal Ganglion  (607.8) Adult Crop    470.4 Adult Midgut  (604.9) Adult Hindgut    487.2 Adult Malpighian Tubules  524.2 Adult Fat Body    286.5 Adult Salivary Gland  (807.6) Adult Heart  505.625 Adult VirginFemale Spermatheca    451 Adult InseminatedFemale Spermatheca  (545.3) Adult Ovary  (611.2) Adult Testis    108.2 Adult Male Accessory Gland  (889.1) Adult Carcass    267.3 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    933.2 Larval Midgut    565.5 Larval Hindgut    500.6 Larval Malpighian Tubules    491.9 Larval Fat Body    286 Larval Salivary Gland    629.5 Larval Trachea    744.7 Larval Carcass    379.5 Adult Head    434 Adult Eye    377.775 Adult Brain    509 Adult Thoracic-Abdominal Ganglion    607.8 Adult Crop    470.4 Adult Midgut    604.9 Adult Hindgut    487.2 Adult Malpighian Tubules    524.2 Adult Fat Body    286.5 Adult Salivary Gland    807.6 Adult Heart    505.625 Adult VirginFemale Spermatheca    451 Adult InseminatedFemale Spermatheca    545.3 Adult Ovary    611.2 Adult Testis    108.2 Adult Male Accessory Gland    889.1 Adult Carcass    267.3 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    933.2 Larval Midgut    565.5 Larval Hindgut    500.6 Larval Malpighian Tubules    491.9 Larval Fat Body    286 Larval Salivary Gland    629.5 Larval Trachea    744.7 Larval Carcass    379.5 Adult Head    434 Adult Eye    377.775 Adult Brain    509 Adult Thoracic-Abdominal Ganglion    607.8 Adult Crop    470.4 Adult Midgut    604.9 Adult Hindgut    487.2 Adult Malpighian Tubules    524.2 Adult Fat Body    286.5 Adult Salivary Gland    807.6 Adult Heart    505.625 Adult VirginFemale Spermatheca    451 Adult InseminatedFemale Spermatheca    545.3 Adult Ovary    611.2 Adult Testis    108.2 Adult Male Accessory Gland    889.1 Adult Carcass    267.3 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    933.2 Larval Midgut    565.5 Larval Hindgut    500.6 Larval Malpighian Tubules    491.9 Larval Fat Body    286 Larval Salivary Gland    629.5 Larval Trachea    744.7 Larval Carcass    379.5 Adult Head    434 Adult Eye    377.775 Adult Brain    509 Adult Thoracic-Abdominal Ganglion    607.8 Adult Crop    470.4 Adult Midgut    604.9 Adult Hindgut    487.2 Adult Malpighian Tubules    524.2 Adult Fat Body    286.5 Adult Salivary Gland    807.6 Adult Heart    505.625 Adult VirginFemale Spermatheca    451 Adult InseminatedFemale Spermatheca    545.3 Adult Ovary    611.2 Adult Testis    108.2 Adult Male Accessory Gland    889.1 Adult Carcass    267.3 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (933.2) Larval Midgut  565.5 Larval Hindgut  500.6 Larval Malpighian Tubules    491.9 Larval Fat Body    286 Larval Salivary Gland  629.5 Larval Trachea  744.7 Larval Carcass    379.5 Adult Head    434 Adult Eye    377.775 Adult Brain  509 Adult Thoracic-Abdominal Ganglion  607.8 Adult Crop    470.4 Adult Midgut  604.9 Adult Hindgut    487.2 Adult Malpighian Tubules  524.2 Adult Fat Body    286.5 Adult Salivary Gland  807.6 Adult Heart  505.625 Adult VirginFemale Spermatheca    451 Adult InseminatedFemale Spermatheca  545.3 Adult Ovary  611.2 Adult Testis    108.2 Adult Male Accessory Gland  (889.1) Adult Carcass    267.3 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    933.2 Larval Midgut    565.5 Larval Hindgut    500.6 Larval Malpighian Tubules    491.9 Larval Fat Body    286 Larval Salivary Gland    629.5 Larval Trachea    744.7 Larval Carcass    379.5 Adult Head    434 Adult Eye    377.775 Adult Brain    509 Adult Thoracic-Abdominal Ganglion    607.8 Adult Crop    470.4 Adult Midgut    604.9 Adult Hindgut    487.2 Adult Malpighian Tubules    524.2 Adult Fat Body    286.5 Adult Salivary Gland    807.6 Adult Heart    505.625 Adult VirginFemale Spermatheca    451 Adult InseminatedFemale Spermatheca    545.3 Adult Ovary    611.2 Adult Testis    108.2 Adult Male Accessory Gland    889.1 Adult Carcass    267.3 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    933.2 Larval Midgut    565.5 Larval Hindgut    500.6 Larval Malpighian Tubules    491.9 Larval Fat Body    286 Larval Salivary Gland    629.5 Larval Trachea    744.7 Larval Carcass    379.5 Adult Head    434 Adult Eye    377.775 Adult Brain    509 Adult Thoracic-Abdominal Ganglion    607.8 Adult Crop    470.4 Adult Midgut    604.9 Adult Hindgut    487.2 Adult Malpighian Tubules    524.2 Adult Fat Body    286.5 Adult Salivary Gland    807.6 Adult Heart    505.625 Adult VirginFemale Spermatheca    451 Adult InseminatedFemale Spermatheca    545.3 Adult Ovary    611.2 Adult Testis    108.2 Adult Male Accessory Gland    889.1 Adult Carcass    267.3 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    434   NA  Eye    377.775   NA  Brain    509   933.2  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    607.8   NA  Crop    470.4   565.5  Midgut    604.9   500.6  Hindgut    487.2   491.9  Malpighian Tubules    524.2   286  Fat Body    286.5   629.5  Salivary Gland    807.6   NA  Heart    505.625   744.7  Trachea    NA   NA  VirginFemale Spermatheca    451   NA  InseminatedFemale Spermatheca    545.3   NA  Ovary    611.2   NA  Testis    108.2   NA  Male Accessory Gland    889.1   379.5  Carcass    267.3 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    13 central nervous system, larvae L3    25 central nervous system, pupae P8    23 head, virgin 1-day female    5 head, virgin 4-day female    4 head, virgin 20-day female    8 head, mated 1-day female    4 head, mated 4-day female    5 head, mated 20-day female    6 head, mated 1-day male    7 head, mated 4-day male    7 head, mated 20-day male    9 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    9 digestive system, larvae L3 wandering    10 digestive system, 1-day adult    5 digestive system, 4-day adult    7 digestive system, 20-day adult    7 fat body, larvae L3 wandering    2 fat body, white prepupae    7 fat body, pupae P8    11 carcass, larvae L3 wandering    13 carcass, 1-day adult    4 carcass, 4-day adult    4 carcass, 20-day adult    5 ovary, virgin 4-day female    20 ovary, mated 4-day female    15 testis, mated 4-day male    6 accessory gland, mated 4-day male    7 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    13 central nervous system, larvae L3    25 central nervous system, pupae P8    23 head, virgin 1-day female    5 head, virgin 4-day female    4 head, virgin 20-day female    8 head, mated 1-day female    4 head, mated 4-day female    5 head, mated 20-day female    6 head, mated 1-day male    7 head, mated 4-day male    7 head, mated 20-day male    9 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    9 digestive system, larvae L3 wandering    10 digestive system, 1-day adult    5 digestive system, 4-day adult    7 digestive system, 20-day adult    7 fat body, larvae L3 wandering    2 fat body, white prepupae    7 fat body, pupae P8    11 carcass, larvae L3 wandering    13 carcass, 1-day adult    4 carcass, 4-day adult    4 carcass, 20-day adult    5 ovary, virgin 4-day female    20 ovary, mated 4-day female    15 testis, mated 4-day male    6 accessory gland, mated 4-day male    7 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    13 central nervous system, larvae L3    25 central nervous system, pupae P8    23 head, virgin 1-day female    5 head, virgin 4-day female    4 head, virgin 20-day female    8 head, mated 1-day female    4 head, mated 4-day female    5 head, mated 20-day female    6 head, mated 1-day male    7 head, mated 4-day male    7 head, mated 20-day male    9 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    9 digestive system, larvae L3 wandering    10 digestive system, 1-day adult    5 digestive system, 4-day adult    7 digestive system, 20-day adult    7 fat body, larvae L3 wandering    2 fat body, white prepupae    7 fat body, pupae P8    11 carcass, larvae L3 wandering    13 carcass, 1-day adult    4 carcass, 4-day adult    4 carcass, 20-day adult    5 ovary, virgin 4-day female    20 ovary, mated 4-day female    15 testis, mated 4-day male    6 accessory gland, mated 4-day male    7 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    13 central nervous system, larvae L3    25 central nervous system, pupae P8    23 head, virgin 1-day female    5 head, virgin 4-day female    4 head, virgin 20-day female    8 head, mated 1-day female    4 head, mated 4-day female    5 head, mated 20-day female    6 head, mated 1-day male    7 head, mated 4-day male    7 head, mated 20-day male    9 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    9 digestive system, larvae L3 wandering    10 digestive system, 1-day adult    5 digestive system, 4-day adult    7 digestive system, 20-day adult    7 fat body, larvae L3 wandering    2 fat body, white prepupae    7 fat body, pupae P8    11 carcass, larvae L3 wandering    13 carcass, 1-day adult    4 carcass, 4-day adult    4 carcass, 20-day adult    5 ovary, virgin 4-day female    20 ovary, mated 4-day female    15 testis, mated 4-day male    6 accessory gland, mated 4-day male    7 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    13 central nervous system, larvae L3    25 central nervous system, pupae P8    23 head, virgin 1-day female    5 head, virgin 4-day female    4 head, virgin 20-day female    8 head, mated 1-day female    4 head, mated 4-day female    5 head, mated 20-day female    6 head, mated 1-day male    7 head, mated 4-day male    7 head, mated 20-day male    9 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    9 digestive system, larvae L3 wandering    10 digestive system, 1-day adult    5 digestive system, 4-day adult    7 digestive system, 20-day adult    7 fat body, larvae L3 wandering    2 fat body, white prepupae    7 fat body, pupae P8    11 carcass, larvae L3 wandering    13 carcass, 1-day adult    4 carcass, 4-day adult    4 carcass, 20-day adult    5 ovary, virgin 4-day female    20 ovary, mated 4-day female    15 testis, mated 4-day male    6 accessory gland, mated 4-day male    7 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    13 central nervous system, larvae L3    25 central nervous system, pupae P8    23 head, virgin 1-day female    5 head, virgin 4-day female    4 head, virgin 20-day female    8 head, mated 1-day female    4 head, mated 4-day female    5 head, mated 20-day female    6 head, mated 1-day male    7 head, mated 4-day male    7 head, mated 20-day male    9 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    9 digestive system, larvae L3 wandering    10 digestive system, 1-day adult    5 digestive system, 4-day adult    7 digestive system, 20-day adult    7 fat body, larvae L3 wandering    2 fat body, white prepupae    7 fat body, pupae P8    11 carcass, larvae L3 wandering    13 carcass, 1-day adult    4 carcass, 4-day adult    4 carcass, 20-day adult    5 ovary, virgin 4-day female    20 ovary, mated 4-day female    15 testis, mated 4-day male    6 accessory gland, mated 4-day male    7 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    13 central nervous system, larvae L3    25 central nervous system, pupae P8    23 head, virgin 1-day female    5 head, virgin 4-day female    4 head, virgin 20-day female    8 head, mated 1-day female    4 head, mated 4-day female    5 head, mated 20-day female    6 head, mated 1-day male    7 head, mated 4-day male    7 head, mated 20-day male    9 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    9 digestive system, larvae L3 wandering    10 digestive system, 1-day adult    5 digestive system, 4-day adult    7 digestive system, 20-day adult    7 fat body, larvae L3 wandering    2 fat body, white prepupae    7 fat body, pupae P8    11 carcass, larvae L3 wandering    13 carcass, 1-day adult    4 carcass, 4-day adult    4 carcass, 20-day adult    5 ovary, virgin 4-day female    20 ovary, mated 4-day female    15 testis, mated 4-day male    6 accessory gland, mated 4-day male    7 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    13 central nervous system, larvae L3    25 central nervous system, pupae P8    23 head, virgin 1-day female    5 head, virgin 4-day female    4 head, virgin 20-day female    8 head, mated 1-day female    4 head, mated 4-day female    5 head, mated 20-day female    6 head, mated 1-day male    7 head, mated 4-day male    7 head, mated 20-day male    9 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    9 digestive system, larvae L3 wandering    10 digestive system, 1-day adult    5 digestive system, 4-day adult    7 digestive system, 20-day adult    7 fat body, larvae L3 wandering    2 fat body, white prepupae    7 fat body, pupae P8    11 carcass, larvae L3 wandering    13 carcass, 1-day adult    4 carcass, 4-day adult    4 carcass, 20-day adult    5 ovary, virgin 4-day female    20 ovary, mated 4-day female    15 testis, mated 4-day male    6 accessory gland, mated 4-day male    7 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-18 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    48 embryo 02-04hr    81 embryo 04-06hr    99 embryo 06-08hr    91 embryo 08-10hr    94 embryo 10-12hr    89 embryo 12-14hr    65 embryo 14-16hr    59 embryo 16-18hr    45 embryo 18-20hr    33 embryo 20-22hr    36 embryo 22-24hr    36 larva L1    23 larva L2    18 larva L3 12hr old    14 larva L3 puffstage 1-2    16 larva L3 puffstage 3-6    25 larva L3 puffstage 7-9    30 white prepupae new    36 white prepupae 12hr    33 white prepupae 24hr    42 pupae 2d postWPP    31 pupae 3d postWPP    19 pupae 4d postWPP    13 adult male 01day    14 adult male 05day    15 adult male 30day    16 adult female 01day    26 adult female 05day    36 adult female 30day    34 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (48) embryo 02-04hr  (81) embryo 04-06hr  (99) embryo 06-08hr  (91) embryo 08-10hr  (94) embryo 10-12hr  (89) embryo 12-14hr  (65) embryo 14-16hr  (59) embryo 16-18hr  (45) embryo 18-20hr  (33) embryo 20-22hr  (36) embryo 22-24hr  (36) larva L1    23 larva L2    18 larva L3 12hr old    14 larva L3 puffstage 1-2    16 larva L3 puffstage 3-6    25 larva L3 puffstage 7-9  (30) white prepupae new  (36) white prepupae 12hr  (33) white prepupae 24hr  (42) pupae 2d postWPP  (31) pupae 3d postWPP    19 pupae 4d postWPP    13 adult male 01day    14 adult male 05day    15 adult male 30day    16 adult female 01day  26 adult female 05day  (36) adult female 30day  (34) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    48 embryo 02-04hr    81 embryo 04-06hr    99 embryo 06-08hr    91 embryo 08-10hr    94 embryo 10-12hr    89 embryo 12-14hr    65 embryo 14-16hr    59 embryo 16-18hr    45 embryo 18-20hr    33 embryo 20-22hr    36 embryo 22-24hr    36 larva L1    23 larva L2    18 larva L3 12hr old    14 larva L3 puffstage 1-2    16 larva L3 puffstage 3-6    25 larva L3 puffstage 7-9    30 white prepupae new    36 white prepupae 12hr    33 white prepupae 24hr    42 pupae 2d postWPP    31 pupae 3d postWPP    19 pupae 4d postWPP    13 adult male 01day    14 adult male 05day    15 adult male 30day    16 adult female 01day    26 adult female 05day    36 adult female 30day    34 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    48 embryo 02-04hr    81 embryo 04-06hr    99 embryo 06-08hr    91 embryo 08-10hr    94 embryo 10-12hr    89 embryo 12-14hr    65 embryo 14-16hr    59 embryo 16-18hr    45 embryo 18-20hr    33 embryo 20-22hr    36 embryo 22-24hr    36 larva L1    23 larva L2    18 larva L3 12hr old    14 larva L3 puffstage 1-2    16 larva L3 puffstage 3-6    25 larva L3 puffstage 7-9    30 white prepupae new    36 white prepupae 12hr    33 white prepupae 24hr    42 pupae 2d postWPP    31 pupae 3d postWPP    19 pupae 4d postWPP    13 adult male 01day    14 adult male 05day    15 adult male 30day    16 adult female 01day    26 adult female 05day    36 adult female 30day    34 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    48 embryo 02-04hr    81 embryo 04-06hr    99 embryo 06-08hr    91 embryo 08-10hr    94 embryo 10-12hr    89 embryo 12-14hr    65 embryo 14-16hr    59 embryo 16-18hr    45 embryo 18-20hr    33 embryo 20-22hr    36 embryo 22-24hr    36 larva L1    23 larva L2    18 larva L3 12hr old    14 larva L3 puffstage 1-2    16 larva L3 puffstage 3-6    25 larva L3 puffstage 7-9    30 white prepupae new    36 white prepupae 12hr    33 white prepupae 24hr    42 pupae 2d postWPP    31 pupae 3d postWPP    19 pupae 4d postWPP    13 adult male 01day    14 adult male 05day    15 adult male 30day    16 adult female 01day    26 adult female 05day    36 adult female 30day    34 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (48) embryo 02-04hr  (81) embryo 04-06hr  (99) embryo 06-08hr  (91) embryo 08-10hr  (94) embryo 10-12hr  (89) embryo 12-14hr  (65) embryo 14-16hr  (59) embryo 16-18hr  (45) embryo 18-20hr  (33) embryo 20-22hr  (36) embryo 22-24hr  (36) larva L1    23 larva L2    18 larva L3 12hr old    14 larva L3 puffstage 1-2    16 larva L3 puffstage 3-6    25 larva L3 puffstage 7-9  30 white prepupae new  (36) white prepupae 12hr  (33) white prepupae 24hr  (42) pupae 2d postWPP  31 pupae 3d postWPP    19 pupae 4d postWPP    13 adult male 01day    14 adult male 05day    15 adult male 30day    16 adult female 01day  26 adult female 05day  (36) adult female 30day  (34) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    48 embryo 02-04hr    81 embryo 04-06hr    99 embryo 06-08hr    91 embryo 08-10hr    94 embryo 10-12hr    89 embryo 12-14hr    65 embryo 14-16hr    59 embryo 16-18hr    45 embryo 18-20hr    33 embryo 20-22hr    36 embryo 22-24hr    36 larva L1    23 larva L2    18 larva L3 12hr old    14 larva L3 puffstage 1-2    16 larva L3 puffstage 3-6    25 larva L3 puffstage 7-9    30 white prepupae new    36 white prepupae 12hr    33 white prepupae 24hr    42 pupae 2d postWPP    31 pupae 3d postWPP    19 pupae 4d postWPP    13 adult male 01day    14 adult male 05day    15 adult male 30day    16 adult female 01day    26 adult female 05day    36 adult female 30day    34 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    48 embryo 02-04hr    81 embryo 04-06hr    99 embryo 06-08hr    91 embryo 08-10hr    94 embryo 10-12hr    89 embryo 12-14hr    65 embryo 14-16hr    59 embryo 16-18hr    45 embryo 18-20hr    33 embryo 20-22hr    36 embryo 22-24hr    36 larva L1    23 larva L2    18 larva L3 12hr old    14 larva L3 puffstage 1-2    16 larva L3 puffstage 3-6    25 larva L3 puffstage 7-9    30 white prepupae new    36 white prepupae 12hr    33 white prepupae 24hr    42 pupae 2d postWPP    31 pupae 3d postWPP    19 pupae 4d postWPP    13 adult male 01day    14 adult male 05day    15 adult male 30day    16 adult female 01day    26 adult female 05day    36 adult female 30day    34 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    41 Schneider line 2 Sg4    46 embryonic 1182-4H    53 embryonic GM2    42 embryonic Kc167    44 embryonic S1    25 embryonic S3    32 leg disc CME L1    40 wing disc CME-W2    44 wing disc ML-DmD8    31 wing disc ML-DmD9    24 wing disc ML-DmD16-c3    27 wing disc ML-DmD21    13 wing disc ML-DmD32    32 haltere disc ML-DmD17-c3    47 eye-antennal disc ML-DmD11    26 antennal disc ML-DmD20-c5    32 mixed discs ML-DmD4-c1    33 CNS ML-DmBG1-c1    29 CNS ML-DmBG2-c2    37 tumorous blood cells mbn2    32 ovary fGS/OSS    16 ovary OSC    13 ovary OSS    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (41) Schneider line 2 Sg4  (46) embryonic 1182-4H  (53) embryonic GM2  (42) embryonic Kc167  (44) embryonic S1    25 embryonic S3  (32) leg disc CME L1  (40) wing disc CME-W2  (44) wing disc ML-DmD8  (31) wing disc ML-DmD9    24 wing disc ML-DmD16-c3  (27) wing disc ML-DmD21    13 wing disc ML-DmD32  (32) haltere disc ML-DmD17-c3  (47) eye-antennal disc ML-DmD11  26 antennal disc ML-DmD20-c5  (32) mixed discs ML-DmD4-c1  (33) CNS ML-DmBG1-c1  (29) CNS ML-DmBG2-c2  (37) tumorous blood cells mbn2  (32) ovary fGS/OSS    16 ovary OSC    13 ovary OSS    8 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    41 Schneider line 2 Sg4    46 embryonic 1182-4H    53 embryonic GM2    42 embryonic Kc167    44 embryonic S1    25 embryonic S3    32 leg disc CME L1    40 wing disc CME-W2    44 wing disc ML-DmD8    31 wing disc ML-DmD9    24 wing disc ML-DmD16-c3    27 wing disc ML-DmD21    13 wing disc ML-DmD32    32 haltere disc ML-DmD17-c3    47 eye-antennal disc ML-DmD11    26 antennal disc ML-DmD20-c5    32 mixed discs ML-DmD4-c1    33 CNS ML-DmBG1-c1    29 CNS ML-DmBG2-c2    37 tumorous blood cells mbn2    32 ovary fGS/OSS    16 ovary OSC    13 ovary OSS    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    41 Schneider line 2 Sg4    46 embryonic 1182-4H    53 embryonic GM2    42 embryonic Kc167    44 embryonic S1    25 embryonic S3    32 leg disc CME L1    40 wing disc CME-W2    44 wing disc ML-DmD8    31 wing disc ML-DmD9    24 wing disc ML-DmD16-c3    27 wing disc ML-DmD21    13 wing disc ML-DmD32    32 haltere disc ML-DmD17-c3    47 eye-antennal disc ML-DmD11    26 antennal disc ML-DmD20-c5    32 mixed discs ML-DmD4-c1    33 CNS ML-DmBG1-c1    29 CNS ML-DmBG2-c2    37 tumorous blood cells mbn2    32 ovary fGS/OSS    16 ovary OSC    13 ovary OSS    8 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    41 Schneider line 2 Sg4    46 embryonic 1182-4H    53 embryonic GM2    42 embryonic Kc167    44 embryonic S1    25 embryonic S3    32 leg disc CME L1    40 wing disc CME-W2    44 wing disc ML-DmD8    31 wing disc ML-DmD9    24 wing disc ML-DmD16-c3    27 wing disc ML-DmD21    13 wing disc ML-DmD32    32 haltere disc ML-DmD17-c3    47 eye-antennal disc ML-DmD11    26 antennal disc ML-DmD20-c5    32 mixed discs ML-DmD4-c1    33 CNS ML-DmBG1-c1    29 CNS ML-DmBG2-c2    37 tumorous blood cells mbn2    32 ovary fGS/OSS    16 ovary OSC    13 ovary OSS    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (41) Schneider line 2 Sg4  (46) embryonic 1182-4H  (53) embryonic GM2  (42) embryonic Kc167  (44) embryonic S1    25 embryonic S3  32 leg disc CME L1  (40) wing disc CME-W2  (44) wing disc ML-DmD8  31 wing disc ML-DmD9    24 wing disc ML-DmD16-c3  27 wing disc ML-DmD21    13 wing disc ML-DmD32  32 haltere disc ML-DmD17-c3  (47) eye-antennal disc ML-DmD11  26 antennal disc ML-DmD20-c5  32 mixed discs ML-DmD4-c1  (33) CNS ML-DmBG1-c1  29 CNS ML-DmBG2-c2  (37) tumorous blood cells mbn2  32 ovary fGS/OSS    16 ovary OSC    13 ovary OSS    8 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    41 Schneider line 2 Sg4    46 embryonic 1182-4H    53 embryonic GM2    42 embryonic Kc167    44 embryonic S1    25 embryonic S3    32 leg disc CME L1    40 wing disc CME-W2    44 wing disc ML-DmD8    31 wing disc ML-DmD9    24 wing disc ML-DmD16-c3    27 wing disc ML-DmD21    13 wing disc ML-DmD32    32 haltere disc ML-DmD17-c3    47 eye-antennal disc ML-DmD11    26 antennal disc ML-DmD20-c5    32 mixed discs ML-DmD4-c1    33 CNS ML-DmBG1-c1    29 CNS ML-DmBG2-c2    37 tumorous blood cells mbn2    32 ovary fGS/OSS    16 ovary OSC    13 ovary OSS    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    41 Schneider line 2 Sg4    46 embryonic 1182-4H    53 embryonic GM2    42 embryonic Kc167    44 embryonic S1    25 embryonic S3    32 leg disc CME L1    40 wing disc CME-W2    44 wing disc ML-DmD8    31 wing disc ML-DmD9    24 wing disc ML-DmD16-c3    27 wing disc ML-DmD21    13 wing disc ML-DmD32    32 haltere disc ML-DmD17-c3    47 eye-antennal disc ML-DmD11    26 antennal disc ML-DmD20-c5    32 mixed discs ML-DmD4-c1    33 CNS ML-DmBG1-c1    29 CNS ML-DmBG2-c2    37 tumorous blood cells mbn2    32 ovary fGS/OSS    16 ovary OSC    13 ovary OSS    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    6 cold shock, 4-day adult    6 heat shock, 4-day adult    10 Cadmium 50 mM 6 hrs, larvae L3    7 Cadmium 50 mM 12 hrs, larvae L3    6 Cadmium 50 mM 48 hrs, 4-day adult    9 Cadmium 100 mM 48 hrs, 4-day adult    11 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    7 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    4 Ethanol 2.5% 3 hrs, larvae L3    17 Ethanol 5% 3 hrs, larvae L3    8 Ethanol 10% 3 hrs, larvae L3    6 Caffeine 1.5 mg/ml 4 hrs, larvae L3    8 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    10 Caffeine 25 mg/ml 48 hrs, 4-day adult    5 Paraquat 5 mM 48 hrs, 4-day adult    12 Paraquat 10 mM 48 hrs, 4-day adult    15 Rotenone 2 μg 12 hrs, larvae L3    8 Rotenone 8 μg 12 hrs, larvae L3    6 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    6 cold shock, 4-day adult    6 heat shock, 4-day adult    10 Cadmium 50 mM 6 hrs, larvae L3    7 Cadmium 50 mM 12 hrs, larvae L3    6 Cadmium 50 mM 48 hrs, 4-day adult    9 Cadmium 100 mM 48 hrs, 4-day adult    11 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    7 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    4 Ethanol 2.5% 3 hrs, larvae L3    17 Ethanol 5% 3 hrs, larvae L3    8 Ethanol 10% 3 hrs, larvae L3    6 Caffeine 1.5 mg/ml 4 hrs, larvae L3    8 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    10 Caffeine 25 mg/ml 48 hrs, 4-day adult    5 Paraquat 5 mM 48 hrs, 4-day adult    12 Paraquat 10 mM 48 hrs, 4-day adult    15 Rotenone 2 μg 12 hrs, larvae L3    8 Rotenone 8 μg 12 hrs, larvae L3    6 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    6 cold shock, 4-day adult    6 heat shock, 4-day adult    10 Cadmium 50 mM 6 hrs, larvae L3    7 Cadmium 50 mM 12 hrs, larvae L3    6 Cadmium 50 mM 48 hrs, 4-day adult    9 Cadmium 100 mM 48 hrs, 4-day adult    11 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    7 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    4 Ethanol 2.5% 3 hrs, larvae L3    17 Ethanol 5% 3 hrs, larvae L3    8 Ethanol 10% 3 hrs, larvae L3    6 Caffeine 1.5 mg/ml 4 hrs, larvae L3    8 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    10 Caffeine 25 mg/ml 48 hrs, 4-day adult    5 Paraquat 5 mM 48 hrs, 4-day adult    12 Paraquat 10 mM 48 hrs, 4-day adult    15 Rotenone 2 μg 12 hrs, larvae L3    8 Rotenone 8 μg 12 hrs, larvae L3    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    6 cold shock, 4-day adult    6 heat shock, 4-day adult    10 Cadmium 50 mM 6 hrs, larvae L3    7 Cadmium 50 mM 12 hrs, larvae L3    6 Cadmium 50 mM 48 hrs, 4-day adult    9 Cadmium 100 mM 48 hrs, 4-day adult    11 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    7 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    4 Ethanol 2.5% 3 hrs, larvae L3    17 Ethanol 5% 3 hrs, larvae L3    8 Ethanol 10% 3 hrs, larvae L3    6 Caffeine 1.5 mg/ml 4 hrs, larvae L3    8 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    10 Caffeine 25 mg/ml 48 hrs, 4-day adult    5 Paraquat 5 mM 48 hrs, 4-day adult    12 Paraquat 10 mM 48 hrs, 4-day adult    15 Rotenone 2 μg 12 hrs, larvae L3    8 Rotenone 8 μg 12 hrs, larvae L3    6 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    6 cold shock, 4-day adult    6 heat shock, 4-day adult    10 Cadmium 50 mM 6 hrs, larvae L3    7 Cadmium 50 mM 12 hrs, larvae L3    6 Cadmium 50 mM 48 hrs, 4-day adult    9 Cadmium 100 mM 48 hrs, 4-day adult    11 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    7 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    4 Ethanol 2.5% 3 hrs, larvae L3    17 Ethanol 5% 3 hrs, larvae L3    8 Ethanol 10% 3 hrs, larvae L3    6 Caffeine 1.5 mg/ml 4 hrs, larvae L3    8 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    10 Caffeine 25 mg/ml 48 hrs, 4-day adult    5 Paraquat 5 mM 48 hrs, 4-day adult    12 Paraquat 10 mM 48 hrs, 4-day adult    15 Rotenone 2 μg 12 hrs, larvae L3    8 Rotenone 8 μg 12 hrs, larvae L3    6 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    6 cold shock, 4-day adult    6 heat shock, 4-day adult    10 Cadmium 50 mM 6 hrs, larvae L3    7 Cadmium 50 mM 12 hrs, larvae L3    6 Cadmium 50 mM 48 hrs, 4-day adult    9 Cadmium 100 mM 48 hrs, 4-day adult    11 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    7 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    4 Ethanol 2.5% 3 hrs, larvae L3    17 Ethanol 5% 3 hrs, larvae L3    8 Ethanol 10% 3 hrs, larvae L3    6 Caffeine 1.5 mg/ml 4 hrs, larvae L3    8 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    10 Caffeine 25 mg/ml 48 hrs, 4-day adult    5 Paraquat 5 mM 48 hrs, 4-day adult    12 Paraquat 10 mM 48 hrs, 4-day adult    15 Rotenone 2 μg 12 hrs, larvae L3    8 Rotenone 8 μg 12 hrs, larvae L3    6 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    6 cold shock, 4-day adult    6 heat shock, 4-day adult    10 Cadmium 50 mM 6 hrs, larvae L3    7 Cadmium 50 mM 12 hrs, larvae L3    6 Cadmium 50 mM 48 hrs, 4-day adult    9 Cadmium 100 mM 48 hrs, 4-day adult    11 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    7 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    4 Ethanol 2.5% 3 hrs, larvae L3    17 Ethanol 5% 3 hrs, larvae L3    8 Ethanol 10% 3 hrs, larvae L3    6 Caffeine 1.5 mg/ml 4 hrs, larvae L3    8 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    10 Caffeine 25 mg/ml 48 hrs, 4-day adult    5 Paraquat 5 mM 48 hrs, 4-day adult    12 Paraquat 10 mM 48 hrs, 4-day adult    15 Rotenone 2 μg 12 hrs, larvae L3    8 Rotenone 8 μg 12 hrs, larvae L3    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    6 cold shock, 4-day adult    6 heat shock, 4-day adult    10 Cadmium 50 mM 6 hrs, larvae L3    7 Cadmium 50 mM 12 hrs, larvae L3    6 Cadmium 50 mM 48 hrs, 4-day adult    9 Cadmium 100 mM 48 hrs, 4-day adult    11 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    7 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    4 Ethanol 2.5% 3 hrs, larvae L3    17 Ethanol 5% 3 hrs, larvae L3    8 Ethanol 10% 3 hrs, larvae L3    6 Caffeine 1.5 mg/ml 4 hrs, larvae L3    8 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    10 Caffeine 25 mg/ml 48 hrs, 4-day adult    5 Paraquat 5 mM 48 hrs, 4-day adult    12 Paraquat 10 mM 48 hrs, 4-day adult    15 Rotenone 2 μg 12 hrs, larvae L3    8 Rotenone 8 μg 12 hrs, larvae L3    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_30 mE1_20_mRNA_expression_cluster_03
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0038320 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG4931-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal Sra-185.1 lethal | embryonic stage | germline clone Sra-185.1 lethal | pharate adult stage (with Sra-185.1) Sra-1EP3267 lethal | pharate adult stage (with Sra-1EP3267) Sra-185.1 lethal | pupal stage | recessive Sra-185.1 lethal | recessive Sra-15.2 Sra-18.1 partially lethal - majority live Sra-1EP3267 partially lethal - majority live, with Scer\GAL4[-]: Sra-1EP3267 viable Sra-135.1 Sra-170.1 Sra-1EY06562 viable, with Scer\GAL4elav-C155 Sra-1Scer\UAS.cSa viable, with Scer\GAL4pnr-MD237 Sra-1GD11477 Sterility Allele fertile Sra-1EY06562 Other Phenotypes Allele cell shape defective Sra-1dsRNA.cKa neuroanatomy defective, with Scer\GAL4ey.PH Sra-1dsRNA.Scer\UAS neuroanatomy defective | dominant Sra-185.1 neuroanatomy defective | dominant | larval stage Sra-185.1 visible | adult stage, with Scer\GAL4lz-gal4 Sra-1dsRNA.Scer\UAS.cGa visible | adult stage, with Scer\GAL4lz-gal4, Sra-185.1 Sra-1dsRNA.Scer\UAS.cGa visible | adult stage, with Scer\GAL4lz-gal4, Sra-1dsRNA.Scer\UAS.cGa Sra-185.1 visible | adult stage | somatic clone Sra-185.1 visible | pharate adult stage (with Sra-185.1) Sra-1EP3267 visible | pharate adult stage (with Sra-1EP3267) Sra-185.1 Phenotype manifest in Allele adult head & macrochaeta, with Scer\GAL4sca.PC Sra-1ΔC.Scer\UAS.T:Myr-Src64B Sra-1dsRNA.Scer\UAS axon Sra-185.1 bouton Sra-185.1 commissure Sra-185.1 cone cell | pharate adult stage (with Sra-185.1) Sra-1EP3267 cone cell | pharate adult stage (with Sra-1EP3267) Sra-185.1 cone cell | pupal stage (with Sra-185.1) Sra-1EP3267 cone cell | pupal stage (with Sra-1EP3267) Sra-185.1 embryonic/larval neuromuscular junction Sra-185.1 eye, with Scer\GAL4ey.PH Sra-1dsRNA.Scer\UAS eye | adult stage, with Scer\GAL4lz-gal4 Sra-1dsRNA.Scer\UAS.cGa eye | adult stage, with Scer\GAL4lz-gal4, Sra-185.1 Sra-1dsRNA.Scer\UAS.cGa eye | adult stage, with Scer\GAL4lz-gal4, Sra-1dsRNA.Scer\UAS.cGa Sra-185.1 eye | adult stage | somatic clone Sra-185.1 eye | pharate adult stage (with Sra-185.1) Sra-1EP3267 eye | pharate adult stage (with Sra-1EP3267) Sra-185.1 interommatidial bristle | pharate adult stage (with Sra-185.1) Sra-1EP3267 interommatidial bristle | pharate adult stage (with Sra-1EP3267) Sra-185.1 interommatidial bristle | pharate adult stage | somatic clone Sra-185.1 intersegmental nerve Sra-185.1 larval neuromuscular junction & bouton, with Scer\GAL4elav-C155 Sra-1dsRNA.Scer\UAS lens | pharate adult stage (with Sra-185.1) Sra-1EP3267 lens | pharate adult stage (with Sra-1EP3267) Sra-185.1 lens | pharate adult stage | somatic clone Sra-185.1 longitudinal connective Sra-185.1 microchaeta, with Scer\GAL4sca.PC Sra-1Scer\UAS.T:Myr-Src64B neuromuscular junction & synapse Sra-185.1 ommatidium, with Scer\GAL4ey.PH Sra-1dsRNA.Scer\UAS ommatidium | pharate adult stage (with Sra-185.1) Sra-1EP3267 ommatidium | pharate adult stage (with Sra-1EP3267) Sra-185.1 ommatidium | pharate adult stage | somatic clone Sra-185.1 photoreceptor | adult stage, with Scer\GAL4lz-gal4 Sra-1dsRNA.Scer\UAS.cGa photoreceptor | adult stage, with Scer\GAL4lz-gal4, Sra-185.1 Sra-1dsRNA.Scer\UAS.cGa photoreceptor | adult stage, with Scer\GAL4lz-gal4, Sra-1dsRNA.Scer\UAS.cGa Sra-185.1 photoreceptor | adult stage | somatic clone Sra-185.1 photoreceptor | pupal stage (with Sra-185.1) Sra-1EP3267 photoreceptor | pupal stage (with Sra-1EP3267) Sra-185.1 photoreceptor cell & growth cone & larval brain, with Scer\GAL4ey.PH Sra-1dsRNA.Scer\UAS photoreceptor cell | wandering third instar larval stage, with Scer\GAL4ey.PH Sra-1dsRNA.Scer\UAS presumptive embryonic/larval central nervous system | germline clone Sra-185.1 retina | pharate adult stage (with Sra-185.1) Sra-1EP3267 retina | pharate adult stage (with Sra-1EP3267) Sra-185.1 retina | pharate adult stage | somatic clone Sra-185.1 rhabdomere | adult stage | somatic clone Sra-185.1 rhabdomere | pharate adult stage (with Sra-185.1) Sra-1EP3267 rhabdomere | pharate adult stage (with Sra-1EP3267) Sra-185.1 rhabdomere | pupal stage (with Sra-185.1) Sra-1EP3267 rhabdomere | pupal stage (with Sra-1EP3267) Sra-185.1 S2 cell-line & actin filament | ectopic Sra-1dsRNA.cBa S2 cell-line & filopodium | ectopic Sra-1dsRNA.cBa synapse Sra-185.1 trichogen cell & actin filament & pupa, with Scer\GAL4sca.PC Sra-1ΔC.Scer\UAS.T:Myr-Src64B Sra-1Scer\UAS.T:Myr-Src64B Sra-1dsRNA.Scer\UAS
Classical Alleles ( 11 )
For All Classical Alleles Show
Allele of Sra-1 Class Mutagen Stocks Known lesion Sra-1EY06562 P-element activity 1 -- Sra-1NP3436 1 -- Sra-135.1 wild-type allele P-element activity 0 Yes Sra-15.2 P-element activity 0 -- Sra-170.1 wild-type allele P-element activity 0 Yes Sra-18.1 P-element activity 0 -- Sra-185.1 P-element activity 0 -- Sra-1d02839 P-element activity 0 -- Sra-1EP3267 P-element activity 0 -- Sra-1EP789 P-element activity 0 -- Sra-1unspecified 0 --
Alleles Carried on Transgenic Constructs ( 11 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Sra-1 Class Mutagen Stocks Known lesion Sra-1GD11477 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes Sra-1HMS01754 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Sra-1dsRNA.cBa in vitro construct - RNAi 0 Yes Sra-1dsRNA.cKa in vitro construct - RNAi 0 Yes Sra-1dsRNA.Scer\UAS.cGa in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes Sra-1dsRNA.Scer\UAS in vitro construct - RNAi 0 Yes Sra-1KK101432 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes Sra-1NIG.4931R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes Sra-1Scer\UAS.cSa in vitro construct - regulatory fusion 0 Yes Sra-1Scer\UAS.T:Myr-Src64B in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes Sra-1ΔC.Scer\UAS.T:Myr-Src64B in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3R)Exel6174 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD11477} NA P{KK101432} NA P{NIG.4931R} NA P{TRiP.HMS01754} NA P{UAS-Sra-1.dsRNA.G} NA P{UAS-Sra-1.dsRNA} NA P{UAS-Sra-1.Myr} NA P{UAS-Sra-1.ΔC.Myr} NA characterization construct P{UAS-CYFIP.S} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EP}Sra-1EP789 NA P{EP}Sra-1EP3267 NA P{EPgy2}Sra-1EY06562 NA P{XP}Sra-1d02839 NA insertion of enhancer trap binary system P{GawB}Sra-1NP3436 No
Gene Ontology: Function, Process & Cellular Component ( 13 unique terms )
Terms Based on Experimental Evidence ( 11 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
axon guidance inferred from mutant phenotype (Schenck et al., 2003) cell morphogenesis inferred from mutant phenotype (D'Ambrosio and Vale, 2010) cell projection assembly inferred from mutant phenotype (Kunda et al., 2003) compound eye morphogenesis inferred from mutant phenotype (Galy et al., 2011) cortical actin cytoskeleton organization inferred from mutant phenotype (Kunda et al., 2003) phagocytosis, engulfment inferred from mutant phenotype (Stroschein-Stevenson et al., 2006) regulation of cell shape inferred from mutant phenotype (Kunda et al., 2003) regulation of synapse organization inferred from mutant phenotype (Schenck et al., 2003)
Cellular Component
CV term Evidence References
apical part of cell inferred from direct assay (Galy et al., 2011) cytoplasm inferred from direct assay (Galy et al., 2011) SCAR complex inferred from direct assay (assigned by UniProtKB) (Schenck et al., 2004)
Terms Based on Predictions or Assertions ( 3 terms )
Molecular Function
CV term Evidence References
Rho GTPase binding non-traceable author statement (Langmann, 2001.4.3)
Biological Process ( 0 terms)
Cellular Component
CV term Evidence References
cytoplasm inferred from sequence or structural similarity with human CYFIP1 (Schenck et al., 2001) inferred from sequence or structural similarity with human CYFIP2 (Schenck et al., 2001) synapse inferred from sequence or structural similarity with human CYFIP1 (Schenck et al., 2001) inferred from sequence or structural similarity with human CYFIP2 (Schenck et al., 2001)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
Sra-1 - Hem experimental knowledge based (Guruharsha et al., 2011) Sra-1 - SCAR experimental knowledge based, anti tag coimmunoprecipitation, peptide massfingerprinting (Guruharsha et al., 2011, Mintseris et al., 2009.11.23)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Sra-1 allele Gene References Sra-185.1 Fmr1 (Schenck et al., 2004) Sra-1dsRNA.Scer\UAS Hem (Bogdan et al., 2004) Sra-1EP3267 Fmr1 (Schenck et al., 2003, Schenck et al., 2004) Rac1 (Schenck et al., 2003) Sra-1Scer\UAS.T:Myr1 Hem (Bogdan et al., 2004) WASp (Bogdan et al., 2004) Sra-1unspecified Fmr1 (Schenck et al., 2003) Rac1 (Schenck et al., 2003) Sra-1ΔC.Scer\UAS.T:Myr1 Hem (Bogdan et al., 2004)
External Data
Linkouts	DroID - A comprehensive database of gene and protein interactions. • FBgn0038320 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 41861
Orthologs
OrthoDB Orthologs (49) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6P8G3D Dipteran inclusive ortholog search EOG6JWVNF Insect inclusive ortholog search EOG6BP06M Arthropod inclusive ortholog search EOG6J3TXS Metazoa inclusive ortholog search EOG693G9H
Orthologs in Drosophila Species (EOG6P8G3D)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\Sra-1     Drosophila simulans   Dsim\GD19013 Y   Drosophila sechellia   Dsec\GM24222 Y   Drosophila erecta   Dere\GG16915 Y   Drosophila yakuba   Dyak\GE24298 Y   Drosophila ananassae   Dana\GF22994 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA18534 Y   Drosophila persimilis   Dper\GL23243 Y   Drosophila willistoni   Dwil\GK11135 Y   Drosophila virilis   Dvir\GJ14463 Y   Drosophila mojavensis   Dmoj\GI10855 Y   Drosophila grimshawi   Dgri\GH19133 Y
Orthologs in non-Drosophila Dipterans (EOG6JWVNF)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL008021   Anopheles gambiae Malaria mosquito  Agam\AGAP000195   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ017352   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ018855
Orthologs in non-Dipteran Insects (EOG6BP06M)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\Sra-1   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG005503   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH15439   Atta cephalotes Leafcutter ant  Acep\ACEP16748   Camponotus floridanus Florida carpenter ant  Cflo\CFLO21134   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL21856   Linepithema humile Argentine ant  Lhum\LH18917   Pogonomyrmex barbatus Red harvester ant  Pbar\PB20145   Solenopsis invicta Red fire ant  Sinv\SINV16350   Acyrthosiphon pisum Pea aphid  Apim\ACYPI000857   Bombyx mori Silkmoth  Bmor\BGIBMGA001670   Pediculus humanus Human body louse  Phum\PHUM262640   Tribolium castaneum Red flour beetle  Tcas\TC004140
Orthologs in non-Insect Arthropods (EOG6J3TXS)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\JGI_V11_301614   Ixodes scapularis Deer tick  Isca\ISCW009439   Ixodes scapularis Deer tick  Isca\ISCW009438
Orthologs in non-Arthropod Metazoa (EOG693G9H)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\gex-2   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_007272gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_011333gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_022438gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_007722gn   Danio rerio Zebrafish  Drer\OTTDARG00000019867   Danio rerio Zebrafish  Drer\cyfip2   Xenopus tropicalis Western clawed frog  Xtro\cyfip2   Xenopus tropicalis Western clawed frog  Xtro\cyfip1   Gallus gallus Domestic chicken  Ggal\CYFIP1   Gallus gallus Domestic chicken  Ggal\CYFIP2   Mus musculus House mouse  Mmus\Cyfip1   Mus musculus House mouse  Mmus\Cyfip2   Rattus norvegicus Norway rat  Rnor\ENSRNOG00000006557   Rattus norvegicus Norway rat  Rnor\Cyfip1   Homo sapiens Human  Hsap\CYFIP1   Homo sapiens Human  Hsap\CYFIP2
Human Orthologs (2)
Gene OMIM HGNC Hsap\CYFIP1     Hsap\CYFIP2
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD19013 Drosophila sechellia Dsec\GM24222 Drosophila erecta Dere\GG16915 Drosophila yakuba Dyak\GE24298 Drosophila ananassae Dana\GF22994 Drosophila pseudoobscura pseudoobscura Dpse\GA18534 Drosophila persimilis Dper\GL23243 Drosophila willistoni Dwil\GK11135 Drosophila virilis Dvir\GJ14463 Drosophila mojavensis Dmoj\GI10855 Drosophila grimshawi Dgri\GH19133
Stocks & Reagents
Stocks Listed in FlyBase ( 5 )
Bloomington	16738 y1 w67c23; P{EPgy2}Sra-1EY06562 38294 y1 sc* v1; P{TRiP.HMS01754}attP2
Kyoto	104503 w*; P{GawB}Sra-1NP3436
VDRC	v34907 w1118; P{GD11477}v34907 v34908 w1118; P{GD11477}v34908
Genomic Clones ( 1 )
	BACR13A02 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 91 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD19991 LD47929 RE62682
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH25824 GM06514 LD14526
Other clones	16311 30078 41824 59588 61778 62511 71109 71332 81820 82820 119190 158952 164518 164717 214343.42 214351.47 214441.41 281193 281803 522623 CK01.27B.B8 CK01.132B.B6 EC30440 EK072924 EK095139 EK117204 EK139305 EK143352 EK155049 EK184320 EK185147 EK188063 EK190805 EK199058 EK200115 EK216064 EK217342 EK238754 EK261922 EK269130 EK298907 EK306416 EK307139 EN02457 EN12704 EP05716 EP09737 EP15055 RH09420 RP003006421 RP003007858 RP003017338 RP003038412 RP003050470 RP003052553 RP003060611 RP003073145 RP003079399 RP003083980 RP003118001 RP003229174 RP003233994 RP003239006 RP003283521 RP003316700 RP003327158 RP003341560 RP003341718 RP003344589 RP003345032 RP003348445 RP003355407 RP003363832 RP003378944 RP003421343 RP003431554 RP003431866 RP003465330 RP003477059 RP003480565 RP003543748 RP003566053 RP003601532 RP003606384 RP003612636
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0038320 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 41861
Antibody Information
	polyclonal (Gautier et al., 2011)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: Sra-1 CG4931 (FlyBase, 1996-)
Source for database merge of
Additional comments	Source for identity of Sra-1 CG4931 was sequence comparison (date:010419). (FlyBase, 1996-)
Other Comments
	S2 cells treated with dsRNA generated against this gene show reduced phagocytosis of Candida albicans compared to untreated cells. (Stroschein-Stevenson et al., 2006) dsRNA made from templates generated with primers directed against this gene is tested in an RNAi screen for effects on actin-based lamella formation. (Rogers et al., 2003) Sra-1 controls neural connectivity in the nervous system. (Schenck et al., 2003)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_142190 RefSeq (Proteins) • NP_650447 DDBJ / EMBL / GenBank • AA540491 AAF55173 AAG61254 AAK31584 AAM52715 AI546369 AQ073761 AQ073869 AW942550 AW943936 AY017343 AY029211 AY122203 CL527920 CZ473025 Entrez Gene - A searchable database of RefSeq genes. • 41861 UniProtKB/Swiss-Prot • Q9VF87
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Cytoplasmic FMR1-interacting (IPR008081) Cytoplasmic FMR1-interacting, subgroup (IPR016536) Protein of unknown function DUF1394 (IPR009828)
Linkouts
	DroID - A comprehensive database of gene and protein interactions. • FBgn0038320 DRSC - Results from RNAi screens. • FBgn0038320 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0038320 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG4931-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0038320 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 41861 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 41861 modMine - Data generated by the modENCODE project. • FBgn0038320
Synonyms & Secondary IDs ( 16 )
Reported As
Symbol Synonym	CG4931 (Rogers et al., 2003, Keleman et al., 2009.8.5, Ni et al., 2010.12.1) CYFIP (Govek, 2005, Schenck et al., 2004, Schenck et al., 2003, Schenck et al., 2003, Billuart and Chelly, 2003, Schenck, 2001.1.9, Qurashi et al., 2007, Schenck et al., 2001, Galy et al., 2011, Qurashi et al., 2007, Reeve et al., 2008, Wang et al., 2012) CYFIP1/2 (Zhang and Broadie, 2005) dSra (Ismail et al., 2009) DSra-1 (Langmann et al., 2002, Langmann, 2001.4.3) PIR121 (Qurashi et al., 2007) PIR121/Sra-1 (Vartiainen and Machesky, 2004) Sra (Bogdan et al., 2004) Sra-1 (Czech et al., 2008, Rogers et al., 2003, Fricke et al., 2009, Stroschein-Stevenson et al., 2006, Yepiskoposyan et al., 2006, Bogdan et al., 2005, Zhu and Bhat, 2011, Stephan et al., 2011, Japanese National Institute of Genetics, 2012.5.21) sra1 (Bogdan et al., 2004) Sra1 (Kunda et al., 2003, D'Ambrosio and Vale, 2010) sra-1 (Gohl et al., 2010) Sra-1/CYFIP (Gohl et al., 2010) Sra1/PIR121 (Chen et al., 2007)
Name Synonym	specifically, Rac-1 associated protein 1 (Stephan et al., 2011) specifically Rac1-associated protein 1 (Bogdan et al., 2004)
Secondary FlyBase IDs
References ( 51 )
Generate a list of	All references relating to this gene ( 51 )
List References by type	Research paper  ( 22 ) Supplementary material  ( 5 ) Review  ( 6 ) Personal communication to FlyBase  ( 8 ) Abstract  ( 4 ) FlyBase analysis  ( 3 ) DNA/RNA sequence record  ( 2 ) Stock list  ( 1 )
Recent research papers ( 6 )
	Bras et al., 2012, J. Cell Sci. 125(20): 4886--4901 Genetic identification of intracellular trafficking regulators involved in Notch-dependent binary cell fate acquisition following asymmetric cell division. [FBrf0220239] Wang et al., 2012, Nat. Commun. 3: 769 Drosophila follicle stem cells are regulated by proliferation and niche adhesion as well as mitochondria and ROS. [FBrf0217898] Galy et al., 2011, Dev. Biol. 359(1): 37--46 CYFIP dependent Actin Remodeling controls specific aspects of Drosophila eye morphogenesis. [FBrf0216378] Gautier et al., 2011, J. Cell Sci. 124(20): 3414--3427 Clathrin is required for Scar/Wave-mediated lamellipodium formation. [FBrf0216441] Stephan et al., 2011, Mol. Biol. Cell 22(21): 4079--4092 Membrane-targeted WAVE mediates photoreceptor axon targeting in the absence of the WAVE complex in Drosophila. [FBrf0216499] Zhu and Bhat, 2011, Dev. Biol. 357(2): 283--294 The Hem protein mediates neuronal migration by inhibiting WAVE degradation and functions opposite of Abelson tyrosine kinase. [FBrf0214765] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...