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Gene Dmel\Arpc3A

General Information
Symbol	Dmel\Arpc3A	Species	D. melanogaster
Name	Arpc3A	Annotation symbol	CG4560
Feature type	protein_coding_gene	FlyBase ID	FBgn0038369
Gene Model Status	Current	Stock availability	4 publicly available
Genomic Location
Chromosome (arm)	3R	Recombination map
Cytogenetic map	89A5-89A5	Sequence location	3R:11,660,370..11,661,434 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Arpc3A is referred to in FlyBase by the symbol Dmel\Arpc3A (CG4560, FBgn0038369). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: actin binding. An electronic pipeline based on InterPro domains suggests that it is involved in the biological process: regulation of actin filament polymerization. 3 alleles are reported. No phenotypic data is available. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: ARP2/3 complex, p21-Arc subunit. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-12 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Two or more Affy2 ProbeSets identify exons of this gene. This is a summary of the tissue expression peaks exhibited in at least one of these ProbeSets. Expression in all larval and adult organs/tissues ranges from low to undetected. Expression at high levels in the following post-embryonic organs or tissues: larval trachea. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, adult female reproductive system, adult male reproductive system, larval/adult carcass. Gene sequence location is 3R:11660370..11661434.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2011_10
FB2012_01	Sequence features BKN32730 HFA15596
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 89A5-89A5   Limits computationally determined from genome sequence between P{PZ}l(3)0653606536 and P{PZ}blp01618
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Arpc3A for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Arpc3A-RC FBtr0300570  NM_142241   814   177 Arpc3A-RD FBtr0300571  NM_169675   935   160
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Arpc3A-PC   FBpp0289797   20.2   177   9.46     NP_650498   AAF55233 Arpc3A-PD   FBpp0289798   18.3   160   9.28     NP_732075   AAN13678
Additional Polypeptide Data & Comments
Reported size (kDa)	21 (kD observed) (Hudson and Cooley, 2002)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • ARP2/3 complex, p21-Arc subunit (IPR007204)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014297 AAF55233   AE014297 AAN13678   BP541991   BP546215   BT024265   BT024396   CO155875   CO186787   CO193611   CO263656   CO277539   CO303822   CO308629   CO309723   CO311601   CO314692   CO330292   EC059323   EC064870   EC071780   EC080326   EC089810   EC199840   EC201964   EC213626   EC214247   EC215080   EC215736   EC216301   EC216451   EC226166   EC226212   EC227650   EC240797   EC262060   EL873042   EL873043   EL873126
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q8IND1 Q9VF28
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
western blot Stage Tissue/Position (including subcellular localization) Reference adult stage     (Hudson and Cooley, 2002)
Additional Descriptive Data
	Arpc3A protein was detected in all tissues tested in whole and dissected adult flies. (Hudson and Cooley, 2002)
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0038369    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0038369 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-12 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0038369 expression level Developmental Stage   Expression Level embryo 00-02hr    2770 embryo 02-04hr    1564 embryo 04-06hr    4129 embryo 06-08hr    4573 embryo 08-10hr    5002 embryo 10-12hr    5276 embryo 12-14hr    3609 embryo 14-16hr    2577 embryo 16-18hr    2062 embryo 18-20hr    1942 embryo 20-22hr    1642 embryo 22-24hr    1766 larva L1    1862 larva L2    2465 larva L3 12hr old    1872 larva L3 puffstage 1-2    2097 larva L3 puffstage 3-6    2498 larva L3 puffstage 7-9    3297 white prepupae new    3326 white prepupae 12hr    3189 white prepupae 24hr    3448 pupae 2d postWPP    2576 pupae 3d postWPP    1717 pupae 4d postWPP    1336 adult male 01day    1283 adult male 05day    1572 adult male 30day    1549 adult female 01day    1826 adult female 05day    2557 adult female 30day    2766 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (2770) embryo 02-04hr  (1564) embryo 04-06hr  (4129) embryo 06-08hr  (4573) embryo 08-10hr  (5002) embryo 10-12hr  (5276) embryo 12-14hr  (3609) embryo 14-16hr  (2577) embryo 16-18hr  (2062) embryo 18-20hr  (1942) embryo 20-22hr  (1642) embryo 22-24hr  (1766) larva L1  (1862) larva L2  (2465) larva L3 12hr old  (1872) larva L3 puffstage 1-2  (2097) larva L3 puffstage 3-6  (2498) larva L3 puffstage 7-9  (3297) white prepupae new  (3326) white prepupae 12hr  (3189) white prepupae 24hr  (3448) pupae 2d postWPP  (2576) pupae 3d postWPP  (1717) pupae 4d postWPP  (1336) adult male 01day  (1283) adult male 05day  (1572) adult male 30day  (1549) adult female 01day  (1826) adult female 05day  (2557) adult female 30day  (2766) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (2770) embryo 02-04hr  (1564) embryo 04-06hr  (4129) embryo 06-08hr  (4573) embryo 08-10hr  (5002) embryo 10-12hr  (5276) embryo 12-14hr  (3609) embryo 14-16hr  (2577) embryo 16-18hr  (2062) embryo 18-20hr  (1942) embryo 20-22hr  (1642) embryo 22-24hr  (1766) larva L1  (1862) larva L2  (2465) larva L3 12hr old  (1872) larva L3 puffstage 1-2  (2097) larva L3 puffstage 3-6  (2498) larva L3 puffstage 7-9  (3297) white prepupae new  (3326) white prepupae 12hr  (3189) white prepupae 24hr  (3448) pupae 2d postWPP  (2576) pupae 3d postWPP  (1717) pupae 4d postWPP    1336 adult male 01day    1283 adult male 05day  (1572) adult male 30day  (1549) adult female 01day  (1826) adult female 05day  (2557) adult female 30day  (2766) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    2770 embryo 02-04hr    1564 embryo 04-06hr    4129 embryo 06-08hr    4573 embryo 08-10hr    5002 embryo 10-12hr    5276 embryo 12-14hr    3609 embryo 14-16hr    2577 embryo 16-18hr    2062 embryo 18-20hr    1942 embryo 20-22hr    1642 embryo 22-24hr    1766 larva L1    1862 larva L2    2465 larva L3 12hr old    1872 larva L3 puffstage 1-2    2097 larva L3 puffstage 3-6    2498 larva L3 puffstage 7-9    3297 white prepupae new    3326 white prepupae 12hr    3189 white prepupae 24hr    3448 pupae 2d postWPP    2576 pupae 3d postWPP    1717 pupae 4d postWPP    1336 adult male 01day    1283 adult male 05day    1572 adult male 30day    1549 adult female 01day    1826 adult female 05day    2557 adult female 30day    2766 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    2770 embryo 02-04hr    1564 embryo 04-06hr    4129 embryo 06-08hr    4573 embryo 08-10hr    5002 embryo 10-12hr    5276 embryo 12-14hr    3609 embryo 14-16hr    2577 embryo 16-18hr    2062 embryo 18-20hr    1942 embryo 20-22hr    1642 embryo 22-24hr    1766 larva L1    1862 larva L2    2465 larva L3 12hr old    1872 larva L3 puffstage 1-2    2097 larva L3 puffstage 3-6    2498 larva L3 puffstage 7-9    3297 white prepupae new    3326 white prepupae 12hr    3189 white prepupae 24hr    3448 pupae 2d postWPP    2576 pupae 3d postWPP    1717 pupae 4d postWPP    1336 adult male 01day    1283 adult male 05day    1572 adult male 30day    1549 adult female 01day    1826 adult female 05day    2557 adult female 30day    2766 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0038369 expression level Developmental Stage   Expression Level embryo 00-02hr    2770 embryo 02-04hr    1564 embryo 04-06hr    4129 embryo 06-08hr    4573 embryo 08-10hr    5002 embryo 10-12hr    5276 embryo 12-14hr    3609 embryo 14-16hr    2577 embryo 16-18hr    2062 embryo 18-20hr    1942 embryo 20-22hr    1642 embryo 22-24hr    1766 larva L1    1862 larva L2    2465 larva L3 12hr old    1872 larva L3 puffstage 1-2    2097 larva L3 puffstage 3-6    2498 larva L3 puffstage 7-9    3297 white prepupae new    3326 white prepupae 12hr    3189 white prepupae 24hr    3448 pupae 2d postWPP    2576 pupae 3d postWPP    1717 pupae 4d postWPP    1336 adult male 01day    1283 adult male 05day    1572 adult male 30day    1549 adult female 01day    1826 adult female 05day    2557 adult female 30day    2766 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (2770) embryo 02-04hr  (1564) embryo 04-06hr  (4129) embryo 06-08hr  (4573) embryo 08-10hr  (5002) embryo 10-12hr  (5276) embryo 12-14hr  (3609) embryo 14-16hr  (2577) embryo 16-18hr  (2062) embryo 18-20hr  (1942) embryo 20-22hr  (1642) embryo 22-24hr  (1766) larva L1  (1862) larva L2  (2465) larva L3 12hr old  (1872) larva L3 puffstage 1-2  (2097) larva L3 puffstage 3-6  (2498) larva L3 puffstage 7-9  (3297) white prepupae new  (3326) white prepupae 12hr  (3189) white prepupae 24hr  (3448) pupae 2d postWPP  (2576) pupae 3d postWPP  (1717) pupae 4d postWPP  (1336) adult male 01day  (1283) adult male 05day  (1572) adult male 30day  (1549) adult female 01day  (1826) adult female 05day  (2557) adult female 30day  (2766) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (2770) embryo 02-04hr  1564 embryo 04-06hr  (4129) embryo 06-08hr  (4573) embryo 08-10hr  (5002) embryo 10-12hr  (5276) embryo 12-14hr  (3609) embryo 14-16hr  (2577) embryo 16-18hr  2062 embryo 18-20hr  1942 embryo 20-22hr  1642 embryo 22-24hr  1766 larva L1  1862 larva L2  2465 larva L3 12hr old  1872 larva L3 puffstage 1-2  2097 larva L3 puffstage 3-6  (2498) larva L3 puffstage 7-9  (3297) white prepupae new  (3326) white prepupae 12hr  (3189) white prepupae 24hr  (3448) pupae 2d postWPP  (2576) pupae 3d postWPP  1717 pupae 4d postWPP    1336 adult male 01day    1283 adult male 05day  1572 adult male 30day  1549 adult female 01day  1826 adult female 05day  (2557) adult female 30day  (2766) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    2770 embryo 02-04hr    1564 embryo 04-06hr    4129 embryo 06-08hr    4573 embryo 08-10hr    5002 embryo 10-12hr    5276 embryo 12-14hr    3609 embryo 14-16hr    2577 embryo 16-18hr    2062 embryo 18-20hr    1942 embryo 20-22hr    1642 embryo 22-24hr    1766 larva L1    1862 larva L2    2465 larva L3 12hr old    1872 larva L3 puffstage 1-2    2097 larva L3 puffstage 3-6    2498 larva L3 puffstage 7-9    3297 white prepupae new    3326 white prepupae 12hr    3189 white prepupae 24hr    3448 pupae 2d postWPP    2576 pupae 3d postWPP    1717 pupae 4d postWPP    1336 adult male 01day    1283 adult male 05day    1572 adult male 30day    1549 adult female 01day    1826 adult female 05day    2557 adult female 30day    2766 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    2770 embryo 02-04hr    1564 embryo 04-06hr    4129 embryo 06-08hr    4573 embryo 08-10hr    5002 embryo 10-12hr    5276 embryo 12-14hr    3609 embryo 14-16hr    2577 embryo 16-18hr    2062 embryo 18-20hr    1942 embryo 20-22hr    1642 embryo 22-24hr    1766 larva L1    1862 larva L2    2465 larva L3 12hr old    1872 larva L3 puffstage 1-2    2097 larva L3 puffstage 3-6    2498 larva L3 puffstage 7-9    3297 white prepupae new    3326 white prepupae 12hr    3189 white prepupae 24hr    3448 pupae 2d postWPP    2576 pupae 3d postWPP    1717 pupae 4d postWPP    1336 adult male 01day    1283 adult male 05day    1572 adult male 30day    1549 adult female 01day    1826 adult female 05day    2557 adult female 30day    2766 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0038369    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0038369 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Two or more Affy2 ProbeSets identify exons of this gene. This is a summary of the tissue expression peaks exhibited in at least one of these ProbeSets. Expression in all larval and adult organs/tissues ranges from low to undetected. Expression at high levels in the following post-embryonic organs or tissues: larval trachea. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, adult female reproductive system, adult male reproductive system, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Heatmap Tissue   Expression Level Larval Central Nervous System no informative data Larval Midgut no informative data Larval Hindgut no informative data Larval Malpighian Tubules no informative data Larval Fat Body no informative data Larval Salivary Gland no informative data Larval Trachea no informative data Larval Carcass no informative data Adult Head no informative data Adult Eye no informative data Adult Brain no informative data Adult Thoracic-Abdominal Ganglion no informative data Adult Crop no informative data Adult Midgut no informative data Adult Hindgut no informative data Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart no informative data Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary no informative data Adult Testis no informative data Adult Male Accessory Gland no informative data Adult Carcass no informative data modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_30
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0038369 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG4560-RB;CG4560-RA;CG4560-RB
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable, with Scer\GAL4pnr-MD237 Arpc3AGD11352 Other Phenotypes Allele visible, with Scer\GAL4pnr-MD237 Arpc3AGD11352 Phenotype manifest in Allele chaeta | supernumerary, with Scer\GAL4pnr-MD237 Arpc3AGD11352
Classical Alleles ( 0 )
For All Classical Alleles Show
Allele of Arpc3A Class Mutagen Stocks Known lesion
Alleles Carried on Transgenic Constructs ( 3 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Arpc3A Class Mutagen Stocks Known lesion Arpc3AGD11352 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes Arpc3AJF02370 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Arpc3AKK112730 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes
Aneuploid Aberrations
Disrupted in	Df(3R)Exel6175 (Ryder, 2004.4.26) Df(3R)Exel8162 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD11352} NA P{KK112730} NA P{TRiP.JF02370} NA
Insertions
	Type of insertions Name Expression data
Gene Ontology: Function, Process & Cellular Component ( 3 unique terms )
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 3 terms )
Molecular Function
CV term Evidence References
actin binding inferred from sequence or structural similarity (Goldstein and Gunawardena, 2000)
Biological Process
CV term Evidence References
regulation of actin filament polymerization inferred from electronic annotation with InterPro:IPR007204 (FlyBase Curators et al., 2004-)
Cellular Component
CV term Evidence References
cytoskeleton inferred from electronic annotation with InterPro:IPR007204 (FlyBase Curators et al., 2004-)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Arpc3A allele Gene References
External Data
Linkouts	DroID - A comprehensive database of gene and protein interactions. • FBgn0038369 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 41917
Orthologs
Genome-wide drosophilid orthologs	Dana\GF18546 Dere\GG16957 Dgri\GH19295 Dmoj\GI23512 Dper\GL22074 Dpse\GA27369 Dsec\GM24264 Dsim\GD19052 Dvir\GJ10263 Dwil\GK12788 Dyak\GE24343
Curated drosophilid orthologs	Dpse\GA18258
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL004475-PB Aedes aegypti (mosquito) AGAP001712-PA Anopheles gambiae (mosquito) XP_001120355.1 Apis mellifera (honey bee) XP_001948675.1 Acyrthosiphon pisum (pea aphid) At1g60430.1 Arabidopsis thaliana (wall cress) 89245 Batrachochytrium dendrobatidis (chytrid fungus) 60971 Branchiostoma floridae (lancelet) XP_001896111.1 Brugia malayi (roundworm nematode) ENSBTAP00000007028 Bos taurus (bovine) CAL0003027 Candida albicans (a form of yeast) CBP03835 Caenorhabditis briggsae (nematode) CE20206 Caenorhabditis elegans (worm) ENSCAFP00000012420 Canis familiaris (dog) CAGL0G04895g Candida glabrata (haploid yeast) ENSCINP00000003763 Ciona intestinalis (sea squirt) JA02148 Caenorhabditis japonica (nematode) cn10153 Cryptococcus neoformans (yeast-like fungus) CPIJ013834 Culex pipens (mosquito) ENSCPOP00000003532 Cavia porcellus (guinea pig) RP23757 Caenorhabditis remanei (nematode) ENSCSAVP00000006878 Ciona savignyi (sedentary tunicate) 171381 Capitella spl (polychaete worm) DDB0201632 Dictyostelium discoideum (amoeba) DEHA2G05412g Debaryomyces Hansenii (yeast) 218090 Daphnia pulex (daphnia) ENSDARP00000075074 Danio rerio (zebra fish) ENSECAP00000018000 Equus caballus (horse) XP_647903 Entamoeba histolytica (anaerobic protozoan) XP_653342 Entamoeba histolytica (anaerobic protozoan) ENSGACP00000023277 Gymnopilus aculeatus (mushroom) ENSGALP00000006046 Gallus gallus (chicken) 72082 Hypsipyla robusta (cedar shoot borer) ENSP00000376449 Homo sapiens (human) ISCW022587-PA Ixodes scapularis (deer tick) KLLA0B07821g Kluyveromyces lactis (yeast) 32654 Monocosta brevicollis (choanoflagellate) ENSMODP00000014558 Monodelphis domestica (gray opossum) ENSMODP00000037579 Monodelphis domestica (gray opossum) ENSMMUP00000008550 Macaca mulatta (rhesus monkey) ENSMUSP00000099584 Mus musculus (house mouse) 235176 Nematostella vectensis (starlet anemone) XP_001608249.1 Nasonia vitripennis (wasp) ENSOANP00000007566 Ornithorynchus anatinus (platypus) ENSORLP00000013628 Oryzias latipes (japanese killifish) LOC_Os02g14000.1 Oryza sativa (asian rice) PHUM003664-PA Pediculus humanus (human body louse) 181136 Physcomitrella patens (moss) ENSPPYP00000005645 Pongo pygmaeus (orangutan) 83250 Phytophthora ramorum (sudden oak death pathogen) 139525 Phytophthora sojae (root rot pathogen) 578872 Populus trichocarpa (black cottonwood) ENSPTRP00000055770 Pan troglodytes (chimpanzee) ENSRNOP00000011499 Rattus norvegicus (norway rat) 5054943 Sorghum bicolor (sorghum) YLR370C Saccharomyces cerevisiae (budding yeast) SPBC1778.08c Schizosaccharomyces pombe (fission yeast) XP_001187887.1 Strongylocentrotus purpuratus (purple sea urchin) XP_974020.1 Tribolium castaneum (red flour beetle) ENSTNIP00000006087 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000002145 Takifugu rubripes (pufferfish Takifugu) 3713.m00147 Tetrahymena thermophila (ciliate protozoa) 83007.m00308 Trichomonas vaginalis (parasitic flagellated protozoan) 87130.m00076 Trichomonas vaginalis (parasitic flagellated protozoan) ENSXETP00000045251 Xenopus tropicalis (frog) YALI0B20240g Yarrowia lipolytica (nonconventional yeast) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB19338 NV10378 LH14569 ISCW022587 FBgn0241464 FBgn0214797 FBgn0197549 FBgn0190559 FBgn0179128 JGI_V11_218090 FBgn0248736 FBgn0159666 FBgn0146238 FBgn0126761 FBgn0109185 FBgn0095564 CPIJ013834 BGIBMGA013120 ACYPI001219 GB14908 AGAP001712 AAEL004475 PHUM528670 GLEAN_15506
Stocks & Reagents
Stocks Listed in FlyBase ( 4 )
Bloomington	27044 y1 v1; P{TRiP.JF02370}attP2
VDRC	v104979 P{KK112730}VIE-260B v26548 w1118; P{GD11352}v26548 v26549 w1118; P{GD11352}v26549
Genomic Clones ( 1 )
	BACR06B08 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 32 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	IP05150 IP15696
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones
Other clones	7564 52410 84363 102259 118231 124500 144289 156184 173878 181163 192173 272604 525662 CK01.26B.G6 CK01.106D.F12 EC36489 EK023159 EK089156 EK125432 EK218958 EK225533 EK237447 EK242828 EK258940 EK294910 EN06913 FGC007H04 FGH104A08 IP04850 IP04950
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0038369 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 41917
Antibody Information
	polyclonal (Hudson and Cooley, 2002)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments
Other Comments
	dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology. (Kiger et al., 2003)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_142241 NM_169675 RefSeq (Proteins) • NP_650498 NP_732075 DDBJ / EMBL / GenBank • AAF55233 AAN13678 Entrez Gene - A searchable database of RefSeq genes. • 41917 UniProtKB/TrEMBL • Q8IND1 Q9VF28
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • ARP2/3 complex, p21-Arc subunit (IPR007204)
Linkouts
	DroID - A comprehensive database of gene and protein interactions. • FBgn0038369 DRSC - Results from RNAi screens. • FBgn0038369 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0038369 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG4560-RB;CG4560-RA;CG4560-RB FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0038369 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 41917 InParanoid A subset of ortholog calls from InParanoid. • AAEL004475-PB Aedes aegypti (mosquito) AGAP001712-PA Anopheles gambiae (mosquito) XP_001120355.1 Apis mellifera (honey bee) XP_001948675.1 Acyrthosiphon pisum (pea aphid) At1g60430.1 Arabidopsis thaliana (wall cress) 89245 Batrachochytrium dendrobatidis (chytrid fungus) 60971 Branchiostoma floridae (lancelet) XP_001896111.1 Brugia malayi (roundworm nematode) ENSBTAP00000007028 Bos taurus (bovine) CAL0003027 Candida albicans (a form of yeast) CBP03835 Caenorhabditis briggsae (nematode) CE20206 Caenorhabditis elegans (worm) ENSCAFP00000012420 Canis familiaris (dog) CAGL0G04895g Candida glabrata (haploid yeast) ENSCINP00000003763 Ciona intestinalis (sea squirt) JA02148 Caenorhabditis japonica (nematode) cn10153 Cryptococcus neoformans (yeast-like fungus) CPIJ013834 Culex pipens (mosquito) ENSCPOP00000003532 Cavia porcellus (guinea pig) RP23757 Caenorhabditis remanei (nematode) ENSCSAVP00000006878 Ciona savignyi (sedentary tunicate) 171381 Capitella spl (polychaete worm) DDB0201632 Dictyostelium discoideum (amoeba) DEHA2G05412g Debaryomyces Hansenii (yeast) 218090 Daphnia pulex (daphnia) ENSDARP00000075074 Danio rerio (zebra fish) ENSECAP00000018000 Equus caballus (horse) XP_647903 Entamoeba histolytica (anaerobic protozoan) XP_653342 Entamoeba histolytica (anaerobic protozoan) ENSGACP00000023277 Gymnopilus aculeatus (mushroom) ENSGALP00000006046 Gallus gallus (chicken) 72082 Hypsipyla robusta (cedar shoot borer) ENSP00000376449 Homo sapiens (human) ISCW022587-PA Ixodes scapularis (deer tick) KLLA0B07821g Kluyveromyces lactis (yeast) 32654 Monocosta brevicollis (choanoflagellate) ENSMODP00000014558 Monodelphis domestica (gray opossum) ENSMODP00000037579 Monodelphis domestica (gray opossum) ENSMMUP00000008550 Macaca mulatta (rhesus monkey) ENSMUSP00000099584 Mus musculus (house mouse) 235176 Nematostella vectensis (starlet anemone) XP_001608249.1 Nasonia vitripennis (wasp) ENSOANP00000007566 Ornithorynchus anatinus (platypus) ENSORLP00000013628 Oryzias latipes (japanese killifish) LOC_Os02g14000.1 Oryza sativa (asian rice) PHUM003664-PA Pediculus humanus (human body louse) 181136 Physcomitrella patens (moss) ENSPPYP00000005645 Pongo pygmaeus (orangutan) 83250 Phytophthora ramorum (sudden oak death pathogen) 139525 Phytophthora sojae (root rot pathogen) 578872 Populus trichocarpa (black cottonwood) ENSPTRP00000055770 Pan troglodytes (chimpanzee) ENSRNOP00000011499 Rattus norvegicus (norway rat) 5054943 Sorghum bicolor (sorghum) YLR370C Saccharomyces cerevisiae (budding yeast) SPBC1778.08c Schizosaccharomyces pombe (fission yeast) XP_001187887.1 Strongylocentrotus purpuratus (purple sea urchin) XP_974020.1 Tribolium castaneum (red flour beetle) ENSTNIP00000006087 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000002145 Takifugu rubripes (pufferfish Takifugu) 3713.m00147 Tetrahymena thermophila (ciliate protozoa) 83007.m00308 Trichomonas vaginalis (parasitic flagellated protozoan) 87130.m00076 Trichomonas vaginalis (parasitic flagellated protozoan) ENSXETP00000045251 Xenopus tropicalis (frog) YALI0B20240g Yarrowia lipolytica (nonconventional yeast) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 41917 modMine - Data generated by the modENCODE project. • FBgn0038369 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB19338 NV10378 LH14569 ISCW022587 FBgn0241464 FBgn0214797 FBgn0197549 FBgn0190559 FBgn0179128 JGI_V11_218090 FBgn0248736 FBgn0159666 FBgn0146238 FBgn0126761 FBgn0109185 FBgn0095564 CPIJ013834 BGIBMGA013120 ACYPI001219 GB14908 AGAP001712 AAEL004475 PHUM528670 GLEAN_15506
Synonyms & Secondary IDs ( 4 )
Reported As
Symbol Synonym	ARC-P21 (Goldstein and Gunawardena, 2000) ARPC (Serio et al., 2010) Arpc3A (Hoopfer et al., 2008) CG4560 (Hudson and Cooley, 2002, Perkins et al., 2009.3.31, Keleman et al., 2009.8.5)
Name Synonym	Arpc3A
Secondary FlyBase IDs
References ( 14 )
Research paper	Serio et al., 2010, Cell Host Microbe 7(5): 388--398 Defining a Core Set of Actin Cytoskeletal Proteins Critical for Actin-Based Motility of Rickettsia. [FBrf0210774] Hoopfer et al., 2008, J. Neurosci. 28(24): 6092--6103 Genomic analysis of Drosophila neuronal remodeling: a role for the RNA-binding protein Boule as a negative regulator of axon pruning. [FBrf0205201] Hudson and Cooley, 2002, J. Cell Biol. 156(4): 677--687 A subset of dynamic actin rearrangements in Drosophila requires the Arp2/3 complex. [FBrf0144947]
Supplementary material	The modENCODE Consortium, 2010, Science 330(6012): DataS14: Gene co-expression clusters. [FBrf0213979] Mummery-Widmer et al., 2009, Nature 458(7241): Supplementary Table 2 - Genome-wide bristle screen results. [FBrf0214518] Kiger et al., 2003, J. Biol. 2(4): Additional data file 1: The gene identity and primer sequences for dsRNAs used in the RNAi screens. [FBrf0174231] Goldstein and Gunawardena, 2000, J. Cell Biol. 150(2): Table S2. Identified cytoskeletal protein coding genes in Drosophila. [FBrf0132100]
Personal communication to FlyBase	Keleman et al., 2009.8.5, RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0208510] Perkins et al., 2009.3.31, TRiP stock collection set 2. TRiP stock collection set 2. [FBrf0207631] Dickson et al., 2007.7.18, RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0200327] FlyBase Curators et al., 2004-, Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. [FBrf0174215] Ryder, 2004.4.26, Exelixis CG deletion data. Exelixis CG deletion data. [FBrf0184335]
FlyBase analysis	FlyBase, 1992-, FlyBase curation FlyBase curation. [FBrf0105495]
Curated genome annotation	Goldstein, 1999.11, [Annotations performed at the Celera Jamboreee.] [Annotations performed at the Celera Jamboreee.] [FBrf0126668]