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Gene Dmel\Hmt-1

General Information
Symbol	Dmel\Hmt-1	Species	D. melanogaster
Name	Heavy metal tolerance factor 1	Annotation symbol	CG4225
Feature type	protein_coding_gene	FlyBase ID	FBgn0038376
Gene Model Status	Current	Stock availability	5 publicly available
Genomic Location
Chromosome (arm)	3R	Recombination map
Cytogenetic map	89A6-89A6	Sequence location	3R:11,679,590..11,683,194 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Heavy metal tolerance factor 1 is referred to in FlyBase by the symbol Dmel\Hmt-1 (CG4225, FBgn0038376). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: ATPase activity, coupled to transmembrane movement of substances; transporter activity; heme transporter activity. There is experimental evidence that it is involved in the biological process: response to cadmium ion. 6 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: AAA+ ATPase domain; ABC transporter, conserved site; ABC transporter, integral membrane type 1; ABC transporter, transmembrane domain; ABC transporter, transmembrane domain, type 1; ABC transporter-like. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-06 hour embryonic stages, in adult female stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, adult fat body, larval/adult salivary gland, adult ovary, adult testis, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1628389_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of Hmt-1. Gene sequence location is 3R:11679590..11683194.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02	Controlled Vocabulary Terms detoxification of cadmium ion
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 89A6-89A6   Limits computationally determined from genome sequence between P{PZ}l(3)0653606536 and P{PZ}blp01618
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Hmt-1 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Hmt-1-RA FBtr0083188  NM_142246   2988   866
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Hmt-1-PA   FBpp0082642   97.9   866   8.47     NP_650503   AAF55241
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • ABC transporter, transmembrane domain (IPR001140) ABC transporter-like (IPR003439) AAA+ ATPase domain (IPR003593) ABC transporter, transmembrane domain, type 1 (IPR011527) P-loop containing nucleoside triphosphate hydrolase (IPR027417) ABC transporter, conserved site (IPR017871) ABC transporter, integral membrane type 1 (IPR017940) MitoDrome - A database of annotated Dmel nuclear genes encoding mitochondrial proteins • MTDROME04225
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014297 AAF55241   AI546605   AQ073966   AW944542   AY084209 AAL89947   BF487323   BF493149   BF499956   BF504883   BG640468   BI213488   CO191677   CO264737   CO279657   CO297155   DU708684   EC075844   EC202934   EC221366   EC221786   EC232790   EC251652   ES696225   ES696226   EV575241   EV596116   GH749378   GH749555   GH750184   GH755014   GH755181   GH760642   GH770313   GH773082   GH775289   GH778863   GH780128   GH781672   GH787422   GH800710   GH813002   GH819871   GH821290   GH826551   GH827516   GH827893   GH827930   GH831025   GH837585   GH845399   GH846467   GH846667   GH847403   GH849609   GH851348   GH851358   GH852662   GH854932   GH856386   GH860755   GH862501   GH867575   GH871883   GH874541   GH879694   GH882784   GH885241   GH889491   GH897720   GH898877   GH913776   GH916408   GH917769   GH919161   GH920989   GH922654   GH922814   GH931472   GH940853
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9VF20
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 3   organism   (Fisher et al., 2012) Comment:maternally deposited embryonic stage 13 -- 16   embryonic/larval midgut   (Fisher et al., 2012) gastric caecum   (Fisher et al., 2012)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 7 of adulthood -- day 49 of adulthood   adult heart   (Cammarato et al., 2011)
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
vacuolar membrane inferred from direct assay (Sooksa-Nguan et al., 2009)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, adult fat body, larval/adult salivary gland, adult ovary, adult testis, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    84.025 Larval Midgut    149.5 Larval Hindgut    135.9 Larval Malpighian Tubules    180.3 Larval Fat Body    60.1 Larval Salivary Gland    105.2 Larval Trachea    96.15 Larval Carcass    149.325 Adult Head    114.7 Adult Eye    147.2 Adult Brain    130.5 Adult Thoracic-Abdominal Ganglion    164.5 Adult Crop    157.5 Adult Midgut    185.7 Adult Hindgut    147 Adult Malpighian Tubules    400.2 Adult Fat Body    458.2 Adult Salivary Gland    139.3 Adult Heart    475.2 Adult VirginFemale Spermatheca    92.7 Adult InseminatedFemale Spermatheca    89.3 Adult Ovary    177.8 Adult Testis    104.6 Adult Male Accessory Gland    81.1 Adult Carcass    409.3 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    84.025 Larval Midgut    149.5 Larval Hindgut    135.9 Larval Malpighian Tubules    180.3 Larval Fat Body    60.1 Larval Salivary Gland    105.2 Larval Trachea    96.15 Larval Carcass    149.325 Adult Head    114.7 Adult Eye    147.2 Adult Brain    130.5 Adult Thoracic-Abdominal Ganglion    164.5 Adult Crop    157.5 Adult Midgut    185.7 Adult Hindgut    147 Adult Malpighian Tubules    400.2 Adult Fat Body    458.2 Adult Salivary Gland    139.3 Adult Heart    475.2 Adult VirginFemale Spermatheca    92.7 Adult InseminatedFemale Spermatheca    89.3 Adult Ovary    177.8 Adult Testis    104.6 Adult Male Accessory Gland    81.1 Adult Carcass    409.3 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    84.025 Larval Midgut    149.5 Larval Hindgut    135.9 Larval Malpighian Tubules    180.3 Larval Fat Body    60.1 Larval Salivary Gland    105.2 Larval Trachea    96.15 Larval Carcass    149.325 Adult Head    114.7 Adult Eye    147.2 Adult Brain    130.5 Adult Thoracic-Abdominal Ganglion    164.5 Adult Crop    157.5 Adult Midgut    185.7 Adult Hindgut    147 Adult Malpighian Tubules    400.2 Adult Fat Body    458.2 Adult Salivary Gland    139.3 Adult Heart    475.2 Adult VirginFemale Spermatheca    92.7 Adult InseminatedFemale Spermatheca    89.3 Adult Ovary    177.8 Adult Testis    104.6 Adult Male Accessory Gland    81.1 Adult Carcass    409.3 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    84.025 Larval Midgut    149.5 Larval Hindgut    135.9 Larval Malpighian Tubules    180.3 Larval Fat Body    60.1 Larval Salivary Gland    105.2 Larval Trachea    96.15 Larval Carcass    149.325 Adult Head    114.7 Adult Eye    147.2 Adult Brain    130.5 Adult Thoracic-Abdominal Ganglion    164.5 Adult Crop    157.5 Adult Midgut    185.7 Adult Hindgut    147 Adult Malpighian Tubules    400.2 Adult Fat Body    458.2 Adult Salivary Gland    139.3 Adult Heart    475.2 Adult VirginFemale Spermatheca    92.7 Adult InseminatedFemale Spermatheca    89.3 Adult Ovary    177.8 Adult Testis    104.6 Adult Male Accessory Gland    81.1 Adult Carcass    409.3 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    84.025 Larval Midgut    149.5 Larval Hindgut    135.9 Larval Malpighian Tubules    180.3 Larval Fat Body    60.1 Larval Salivary Gland    105.2 Larval Trachea    96.15 Larval Carcass    149.325 Adult Head    114.7 Adult Eye    147.2 Adult Brain    130.5 Adult Thoracic-Abdominal Ganglion    164.5 Adult Crop    157.5 Adult Midgut    185.7 Adult Hindgut    147 Adult Malpighian Tubules    400.2 Adult Fat Body    458.2 Adult Salivary Gland    139.3 Adult Heart    475.2 Adult VirginFemale Spermatheca    92.7 Adult InseminatedFemale Spermatheca    89.3 Adult Ovary    177.8 Adult Testis    104.6 Adult Male Accessory Gland    81.1 Adult Carcass    409.3 Expression Level Scale  None   Low   Moderate   High  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    84.025 Larval Midgut    149.5 Larval Hindgut    135.9 Larval Malpighian Tubules    180.3 Larval Fat Body    60.1 Larval Salivary Gland    105.2 Larval Trachea    96.15 Larval Carcass    149.325 Adult Head    114.7 Adult Eye    147.2 Adult Brain    130.5 Adult Thoracic-Abdominal Ganglion    164.5 Adult Crop    157.5 Adult Midgut    185.7 Adult Hindgut    147 Adult Malpighian Tubules    400.2 Adult Fat Body    458.2 Adult Salivary Gland    139.3 Adult Heart    475.2 Adult VirginFemale Spermatheca    92.7 Adult InseminatedFemale Spermatheca    89.3 Adult Ovary    177.8 Adult Testis    104.6 Adult Male Accessory Gland    81.1 Adult Carcass    409.3 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    84.025 Larval Midgut    149.5 Larval Hindgut    135.9 Larval Malpighian Tubules    180.3 Larval Fat Body    60.1 Larval Salivary Gland    105.2 Larval Trachea    96.15 Larval Carcass    149.325 Adult Head    114.7 Adult Eye    147.2 Adult Brain    130.5 Adult Thoracic-Abdominal Ganglion    164.5 Adult Crop    157.5 Adult Midgut    185.7 Adult Hindgut    147 Adult Malpighian Tubules    400.2 Adult Fat Body    458.2 Adult Salivary Gland    139.3 Adult Heart    475.2 Adult VirginFemale Spermatheca    92.7 Adult InseminatedFemale Spermatheca    89.3 Adult Ovary    177.8 Adult Testis    104.6 Adult Male Accessory Gland    81.1 Adult Carcass    409.3 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    84.025 Larval Midgut    149.5 Larval Hindgut    135.9 Larval Malpighian Tubules    180.3 Larval Fat Body    60.1 Larval Salivary Gland    105.2 Larval Trachea    96.15 Larval Carcass    149.325 Adult Head    114.7 Adult Eye    147.2 Adult Brain    130.5 Adult Thoracic-Abdominal Ganglion    164.5 Adult Crop    157.5 Adult Midgut    185.7 Adult Hindgut    147 Adult Malpighian Tubules    400.2 Adult Fat Body    458.2 Adult Salivary Gland    139.3 Adult Heart    475.2 Adult VirginFemale Spermatheca    92.7 Adult InseminatedFemale Spermatheca    89.3 Adult Ovary    177.8 Adult Testis    104.6 Adult Male Accessory Gland    81.1 Adult Carcass    409.3 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    114.7   NA  Eye    147.2   NA  Brain    130.5   84.025  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    164.5   NA  Crop    157.5   149.5  Midgut    185.7   135.9  Hindgut    147   180.3  Malpighian Tubules    400.2   60.1  Fat Body    458.2   105.2  Salivary Gland    139.3   NA  Heart    475.2   96.15  Trachea    NA   NA  VirginFemale Spermatheca    92.7   NA  InseminatedFemale Spermatheca    89.3   NA  Ovary    177.8   NA  Testis    104.6   NA  Male Accessory Gland    81.1   149.325  Carcass    409.3 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    31 central nervous system, larvae L3    17 central nervous system, pupae P8    20 head, virgin 1-day female    17 head, virgin 4-day female    15 head, virgin 20-day female    17 head, mated 1-day female    19 head, mated 4-day female    19 head, mated 20-day female    13 head, mated 1-day male    24 head, mated 4-day male    25 head, mated 20-day male    34 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    7 digestive system, larvae L3 wandering    30 digestive system, 1-day adult    34 digestive system, 4-day adult    33 digestive system, 20-day adult    30 fat body, larvae L3 wandering    5 fat body, white prepupae    9 fat body, pupae P8    16 carcass, larvae L3 wandering    22 carcass, 1-day adult    34 carcass, 4-day adult    47 carcass, 20-day adult    43 ovary, virgin 4-day female    67 ovary, mated 4-day female    60 testis, mated 4-day male    50 accessory gland, mated 4-day male    12 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (31) central nervous system, larvae L3    17 central nervous system, pupae P8    20 head, virgin 1-day female    17 head, virgin 4-day female    15 head, virgin 20-day female    17 head, mated 1-day female    19 head, mated 4-day female    19 head, mated 20-day female    13 head, mated 1-day male    24 head, mated 4-day male    25 head, mated 20-day male  (34) salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    7 digestive system, larvae L3 wandering  (30) digestive system, 1-day adult  (34) digestive system, 4-day adult  (33) digestive system, 20-day adult  (30) fat body, larvae L3 wandering    5 fat body, white prepupae    9 fat body, pupae P8    16 carcass, larvae L3 wandering    22 carcass, 1-day adult  (34) carcass, 4-day adult  (47) carcass, 20-day adult  (43) ovary, virgin 4-day female  (67) ovary, mated 4-day female  (60) testis, mated 4-day male  (50) accessory gland, mated 4-day male    12 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    31 central nervous system, larvae L3    17 central nervous system, pupae P8    20 head, virgin 1-day female    17 head, virgin 4-day female    15 head, virgin 20-day female    17 head, mated 1-day female    19 head, mated 4-day female    19 head, mated 20-day female    13 head, mated 1-day male    24 head, mated 4-day male    25 head, mated 20-day male    34 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    7 digestive system, larvae L3 wandering    30 digestive system, 1-day adult    34 digestive system, 4-day adult    33 digestive system, 20-day adult    30 fat body, larvae L3 wandering    5 fat body, white prepupae    9 fat body, pupae P8    16 carcass, larvae L3 wandering    22 carcass, 1-day adult    34 carcass, 4-day adult    47 carcass, 20-day adult    43 ovary, virgin 4-day female    67 ovary, mated 4-day female    60 testis, mated 4-day male    50 accessory gland, mated 4-day male    12 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    31 central nervous system, larvae L3    17 central nervous system, pupae P8    20 head, virgin 1-day female    17 head, virgin 4-day female    15 head, virgin 20-day female    17 head, mated 1-day female    19 head, mated 4-day female    19 head, mated 20-day female    13 head, mated 1-day male    24 head, mated 4-day male    25 head, mated 20-day male    34 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    7 digestive system, larvae L3 wandering    30 digestive system, 1-day adult    34 digestive system, 4-day adult    33 digestive system, 20-day adult    30 fat body, larvae L3 wandering    5 fat body, white prepupae    9 fat body, pupae P8    16 carcass, larvae L3 wandering    22 carcass, 1-day adult    34 carcass, 4-day adult    47 carcass, 20-day adult    43 ovary, virgin 4-day female    67 ovary, mated 4-day female    60 testis, mated 4-day male    50 accessory gland, mated 4-day male    12 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    31 central nervous system, larvae L3    17 central nervous system, pupae P8    20 head, virgin 1-day female    17 head, virgin 4-day female    15 head, virgin 20-day female    17 head, mated 1-day female    19 head, mated 4-day female    19 head, mated 20-day female    13 head, mated 1-day male    24 head, mated 4-day male    25 head, mated 20-day male    34 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    7 digestive system, larvae L3 wandering    30 digestive system, 1-day adult    34 digestive system, 4-day adult    33 digestive system, 20-day adult    30 fat body, larvae L3 wandering    5 fat body, white prepupae    9 fat body, pupae P8    16 carcass, larvae L3 wandering    22 carcass, 1-day adult    34 carcass, 4-day adult    47 carcass, 20-day adult    43 ovary, virgin 4-day female    67 ovary, mated 4-day female    60 testis, mated 4-day male    50 accessory gland, mated 4-day male    12 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  31 central nervous system, larvae L3    17 central nervous system, pupae P8    20 head, virgin 1-day female    17 head, virgin 4-day female    15 head, virgin 20-day female    17 head, mated 1-day female    19 head, mated 4-day female    19 head, mated 20-day female    13 head, mated 1-day male    24 head, mated 4-day male    25 head, mated 20-day male  (34) salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    7 digestive system, larvae L3 wandering  30 digestive system, 1-day adult  (34) digestive system, 4-day adult  (33) digestive system, 20-day adult  30 fat body, larvae L3 wandering    5 fat body, white prepupae    9 fat body, pupae P8    16 carcass, larvae L3 wandering    22 carcass, 1-day adult  (34) carcass, 4-day adult  (47) carcass, 20-day adult  (43) ovary, virgin 4-day female  (67) ovary, mated 4-day female  (60) testis, mated 4-day male  (50) accessory gland, mated 4-day male    12 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    31 central nervous system, larvae L3    17 central nervous system, pupae P8    20 head, virgin 1-day female    17 head, virgin 4-day female    15 head, virgin 20-day female    17 head, mated 1-day female    19 head, mated 4-day female    19 head, mated 20-day female    13 head, mated 1-day male    24 head, mated 4-day male    25 head, mated 20-day male    34 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    7 digestive system, larvae L3 wandering    30 digestive system, 1-day adult    34 digestive system, 4-day adult    33 digestive system, 20-day adult    30 fat body, larvae L3 wandering    5 fat body, white prepupae    9 fat body, pupae P8    16 carcass, larvae L3 wandering    22 carcass, 1-day adult    34 carcass, 4-day adult    47 carcass, 20-day adult    43 ovary, virgin 4-day female    67 ovary, mated 4-day female    60 testis, mated 4-day male    50 accessory gland, mated 4-day male    12 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    31 central nervous system, larvae L3    17 central nervous system, pupae P8    20 head, virgin 1-day female    17 head, virgin 4-day female    15 head, virgin 20-day female    17 head, mated 1-day female    19 head, mated 4-day female    19 head, mated 20-day female    13 head, mated 1-day male    24 head, mated 4-day male    25 head, mated 20-day male    34 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    7 digestive system, larvae L3 wandering    30 digestive system, 1-day adult    34 digestive system, 4-day adult    33 digestive system, 20-day adult    30 fat body, larvae L3 wandering    5 fat body, white prepupae    9 fat body, pupae P8    16 carcass, larvae L3 wandering    22 carcass, 1-day adult    34 carcass, 4-day adult    47 carcass, 20-day adult    43 ovary, virgin 4-day female    67 ovary, mated 4-day female    60 testis, mated 4-day male    50 accessory gland, mated 4-day male    12 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-06 hour embryonic stages, in adult female stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    71 embryo 02-04hr    13 embryo 04-06hr    30 embryo 06-08hr    22 embryo 08-10hr    19 embryo 10-12hr    20 embryo 12-14hr    15 embryo 14-16hr    21 embryo 16-18hr    30 embryo 18-20hr    23 embryo 20-22hr    18 embryo 22-24hr    20 larva L1    29 larva L2    35 larva L3 12hr old    26 larva L3 puffstage 1-2    21 larva L3 puffstage 3-6    22 larva L3 puffstage 7-9    26 white prepupae new    31 white prepupae 12hr    21 white prepupae 24hr    22 pupae 2d postWPP    19 pupae 3d postWPP    23 pupae 4d postWPP    21 adult male 01day    39 adult male 05day    46 adult male 30day    41 adult female 01day    48 adult female 05day    58 adult female 30day    56 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (71) embryo 02-04hr    13 embryo 04-06hr  (30) embryo 06-08hr    22 embryo 08-10hr    19 embryo 10-12hr    20 embryo 12-14hr    15 embryo 14-16hr    21 embryo 16-18hr  (30) embryo 18-20hr    23 embryo 20-22hr    18 embryo 22-24hr    20 larva L1  (29) larva L2  (35) larva L3 12hr old  26 larva L3 puffstage 1-2    21 larva L3 puffstage 3-6    22 larva L3 puffstage 7-9  26 white prepupae new  (31) white prepupae 12hr    21 white prepupae 24hr    22 pupae 2d postWPP    19 pupae 3d postWPP    23 pupae 4d postWPP    21 adult male 01day  (39) adult male 05day  (46) adult male 30day  (41) adult female 01day  (48) adult female 05day  (58) adult female 30day  (56) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    71 embryo 02-04hr    13 embryo 04-06hr    30 embryo 06-08hr    22 embryo 08-10hr    19 embryo 10-12hr    20 embryo 12-14hr    15 embryo 14-16hr    21 embryo 16-18hr    30 embryo 18-20hr    23 embryo 20-22hr    18 embryo 22-24hr    20 larva L1    29 larva L2    35 larva L3 12hr old    26 larva L3 puffstage 1-2    21 larva L3 puffstage 3-6    22 larva L3 puffstage 7-9    26 white prepupae new    31 white prepupae 12hr    21 white prepupae 24hr    22 pupae 2d postWPP    19 pupae 3d postWPP    23 pupae 4d postWPP    21 adult male 01day    39 adult male 05day    46 adult male 30day    41 adult female 01day    48 adult female 05day    58 adult female 30day    56 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    71 embryo 02-04hr    13 embryo 04-06hr    30 embryo 06-08hr    22 embryo 08-10hr    19 embryo 10-12hr    20 embryo 12-14hr    15 embryo 14-16hr    21 embryo 16-18hr    30 embryo 18-20hr    23 embryo 20-22hr    18 embryo 22-24hr    20 larva L1    29 larva L2    35 larva L3 12hr old    26 larva L3 puffstage 1-2    21 larva L3 puffstage 3-6    22 larva L3 puffstage 7-9    26 white prepupae new    31 white prepupae 12hr    21 white prepupae 24hr    22 pupae 2d postWPP    19 pupae 3d postWPP    23 pupae 4d postWPP    21 adult male 01day    39 adult male 05day    46 adult male 30day    41 adult female 01day    48 adult female 05day    58 adult female 30day    56 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    71 embryo 02-04hr    13 embryo 04-06hr    30 embryo 06-08hr    22 embryo 08-10hr    19 embryo 10-12hr    20 embryo 12-14hr    15 embryo 14-16hr    21 embryo 16-18hr    30 embryo 18-20hr    23 embryo 20-22hr    18 embryo 22-24hr    20 larva L1    29 larva L2    35 larva L3 12hr old    26 larva L3 puffstage 1-2    21 larva L3 puffstage 3-6    22 larva L3 puffstage 7-9    26 white prepupae new    31 white prepupae 12hr    21 white prepupae 24hr    22 pupae 2d postWPP    19 pupae 3d postWPP    23 pupae 4d postWPP    21 adult male 01day    39 adult male 05day    46 adult male 30day    41 adult female 01day    48 adult female 05day    58 adult female 30day    56 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (71) embryo 02-04hr    13 embryo 04-06hr  30 embryo 06-08hr    22 embryo 08-10hr    19 embryo 10-12hr    20 embryo 12-14hr    15 embryo 14-16hr    21 embryo 16-18hr  30 embryo 18-20hr    23 embryo 20-22hr    18 embryo 22-24hr    20 larva L1  29 larva L2  (35) larva L3 12hr old  26 larva L3 puffstage 1-2    21 larva L3 puffstage 3-6    22 larva L3 puffstage 7-9  26 white prepupae new  31 white prepupae 12hr    21 white prepupae 24hr    22 pupae 2d postWPP    19 pupae 3d postWPP    23 pupae 4d postWPP    21 adult male 01day  (39) adult male 05day  (46) adult male 30day  (41) adult female 01day  (48) adult female 05day  (58) adult female 30day  (56) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    71 embryo 02-04hr    13 embryo 04-06hr    30 embryo 06-08hr    22 embryo 08-10hr    19 embryo 10-12hr    20 embryo 12-14hr    15 embryo 14-16hr    21 embryo 16-18hr    30 embryo 18-20hr    23 embryo 20-22hr    18 embryo 22-24hr    20 larva L1    29 larva L2    35 larva L3 12hr old    26 larva L3 puffstage 1-2    21 larva L3 puffstage 3-6    22 larva L3 puffstage 7-9    26 white prepupae new    31 white prepupae 12hr    21 white prepupae 24hr    22 pupae 2d postWPP    19 pupae 3d postWPP    23 pupae 4d postWPP    21 adult male 01day    39 adult male 05day    46 adult male 30day    41 adult female 01day    48 adult female 05day    58 adult female 30day    56 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    71 embryo 02-04hr    13 embryo 04-06hr    30 embryo 06-08hr    22 embryo 08-10hr    19 embryo 10-12hr    20 embryo 12-14hr    15 embryo 14-16hr    21 embryo 16-18hr    30 embryo 18-20hr    23 embryo 20-22hr    18 embryo 22-24hr    20 larva L1    29 larva L2    35 larva L3 12hr old    26 larva L3 puffstage 1-2    21 larva L3 puffstage 3-6    22 larva L3 puffstage 7-9    26 white prepupae new    31 white prepupae 12hr    21 white prepupae 24hr    22 pupae 2d postWPP    19 pupae 3d postWPP    23 pupae 4d postWPP    21 adult male 01day    39 adult male 05day    46 adult male 30day    41 adult female 01day    48 adult female 05day    58 adult female 30day    56 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    90 Schneider line 2 Sg4    43 embryonic 1182-4H    43 embryonic GM2    76 embryonic Kc167    91 embryonic S1    65 embryonic S3    51 leg disc CME L1    34 wing disc CME-W2    40 wing disc ML-DmD8    32 wing disc ML-DmD9    38 wing disc ML-DmD16-c3    38 wing disc ML-DmD21    48 wing disc ML-DmD32    33 haltere disc ML-DmD17-c3    36 eye-antennal disc ML-DmD11    43 antennal disc ML-DmD20-c5    42 mixed discs ML-DmD4-c1    35 CNS ML-DmBG1-c1    33 CNS ML-DmBG2-c2    53 tumorous blood cells mbn2    50 ovary fGS/OSS    40 ovary OSC    28 ovary OSS    20 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (90) Schneider line 2 Sg4  (43) embryonic 1182-4H  (43) embryonic GM2  (76) embryonic Kc167  (91) embryonic S1  (65) embryonic S3  (51) leg disc CME L1  (34) wing disc CME-W2  (40) wing disc ML-DmD8  (32) wing disc ML-DmD9  (38) wing disc ML-DmD16-c3  (38) wing disc ML-DmD21  (48) wing disc ML-DmD32  (33) haltere disc ML-DmD17-c3  (36) eye-antennal disc ML-DmD11  (43) antennal disc ML-DmD20-c5  (42) mixed discs ML-DmD4-c1  (35) CNS ML-DmBG1-c1  (33) CNS ML-DmBG2-c2  (53) tumorous blood cells mbn2  (50) ovary fGS/OSS  (40) ovary OSC  (28) ovary OSS    20 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    90 Schneider line 2 Sg4    43 embryonic 1182-4H    43 embryonic GM2    76 embryonic Kc167    91 embryonic S1    65 embryonic S3    51 leg disc CME L1    34 wing disc CME-W2    40 wing disc ML-DmD8    32 wing disc ML-DmD9    38 wing disc ML-DmD16-c3    38 wing disc ML-DmD21    48 wing disc ML-DmD32    33 haltere disc ML-DmD17-c3    36 eye-antennal disc ML-DmD11    43 antennal disc ML-DmD20-c5    42 mixed discs ML-DmD4-c1    35 CNS ML-DmBG1-c1    33 CNS ML-DmBG2-c2    53 tumorous blood cells mbn2    50 ovary fGS/OSS    40 ovary OSC    28 ovary OSS    20 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    90 Schneider line 2 Sg4    43 embryonic 1182-4H    43 embryonic GM2    76 embryonic Kc167    91 embryonic S1    65 embryonic S3    51 leg disc CME L1    34 wing disc CME-W2    40 wing disc ML-DmD8    32 wing disc ML-DmD9    38 wing disc ML-DmD16-c3    38 wing disc ML-DmD21    48 wing disc ML-DmD32    33 haltere disc ML-DmD17-c3    36 eye-antennal disc ML-DmD11    43 antennal disc ML-DmD20-c5    42 mixed discs ML-DmD4-c1    35 CNS ML-DmBG1-c1    33 CNS ML-DmBG2-c2    53 tumorous blood cells mbn2    50 ovary fGS/OSS    40 ovary OSC    28 ovary OSS    20 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    90 Schneider line 2 Sg4    43 embryonic 1182-4H    43 embryonic GM2    76 embryonic Kc167    91 embryonic S1    65 embryonic S3    51 leg disc CME L1    34 wing disc CME-W2    40 wing disc ML-DmD8    32 wing disc ML-DmD9    38 wing disc ML-DmD16-c3    38 wing disc ML-DmD21    48 wing disc ML-DmD32    33 haltere disc ML-DmD17-c3    36 eye-antennal disc ML-DmD11    43 antennal disc ML-DmD20-c5    42 mixed discs ML-DmD4-c1    35 CNS ML-DmBG1-c1    33 CNS ML-DmBG2-c2    53 tumorous blood cells mbn2    50 ovary fGS/OSS    40 ovary OSC    28 ovary OSS    20 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (90) Schneider line 2 Sg4  (43) embryonic 1182-4H  (43) embryonic GM2  (76) embryonic Kc167  (91) embryonic S1  (65) embryonic S3  (51) leg disc CME L1  (34) wing disc CME-W2  (40) wing disc ML-DmD8  32 wing disc ML-DmD9  (38) wing disc ML-DmD16-c3  (38) wing disc ML-DmD21  (48) wing disc ML-DmD32  (33) haltere disc ML-DmD17-c3  (36) eye-antennal disc ML-DmD11  (43) antennal disc ML-DmD20-c5  (42) mixed discs ML-DmD4-c1  (35) CNS ML-DmBG1-c1  (33) CNS ML-DmBG2-c2  (53) tumorous blood cells mbn2  (50) ovary fGS/OSS  (40) ovary OSC  28 ovary OSS    20 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    90 Schneider line 2 Sg4    43 embryonic 1182-4H    43 embryonic GM2    76 embryonic Kc167    91 embryonic S1    65 embryonic S3    51 leg disc CME L1    34 wing disc CME-W2    40 wing disc ML-DmD8    32 wing disc ML-DmD9    38 wing disc ML-DmD16-c3    38 wing disc ML-DmD21    48 wing disc ML-DmD32    33 haltere disc ML-DmD17-c3    36 eye-antennal disc ML-DmD11    43 antennal disc ML-DmD20-c5    42 mixed discs ML-DmD4-c1    35 CNS ML-DmBG1-c1    33 CNS ML-DmBG2-c2    53 tumorous blood cells mbn2    50 ovary fGS/OSS    40 ovary OSC    28 ovary OSS    20 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    90 Schneider line 2 Sg4    43 embryonic 1182-4H    43 embryonic GM2    76 embryonic Kc167    91 embryonic S1    65 embryonic S3    51 leg disc CME L1    34 wing disc CME-W2    40 wing disc ML-DmD8    32 wing disc ML-DmD9    38 wing disc ML-DmD16-c3    38 wing disc ML-DmD21    48 wing disc ML-DmD32    33 haltere disc ML-DmD17-c3    36 eye-antennal disc ML-DmD11    43 antennal disc ML-DmD20-c5    42 mixed discs ML-DmD4-c1    35 CNS ML-DmBG1-c1    33 CNS ML-DmBG2-c2    53 tumorous blood cells mbn2    50 ovary fGS/OSS    40 ovary OSC    28 ovary OSS    20 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    36 cold shock, 4-day adult    21 heat shock, 4-day adult    40 Cadmium 50 mM 6 hrs, larvae L3    46 Cadmium 50 mM 12 hrs, larvae L3    24 Cadmium 50 mM 48 hrs, 4-day adult    38 Cadmium 100 mM 48 hrs, 4-day adult    48 Copper 0.5 mM 12 hrs, larvae L3    34 Copper 15 mM 48 hrs, 4-day adult    32 Zinc 5 mM 12 hrs, larvae L3    28 Zinc 4.5 mM 48 hrs, 4-day adult    38 Ethanol 2.5% 3 hrs, larvae L3    62 Ethanol 5% 3 hrs, larvae L3    29 Ethanol 10% 3 hrs, larvae L3    26 Caffeine 1.5 mg/ml 4 hrs, larvae L3    30 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    47 Caffeine 25 mg/ml 48 hrs, 4-day adult    32 Paraquat 5 mM 48 hrs, 4-day adult    50 Paraquat 10 mM 48 hrs, 4-day adult    69 Rotenone 2 μg 12 hrs, larvae L3    31 Rotenone 8 μg 12 hrs, larvae L3    29 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (36) cold shock, 4-day adult    21 heat shock, 4-day adult  (40) Cadmium 50 mM 6 hrs, larvae L3  (46) Cadmium 50 mM 12 hrs, larvae L3    24 Cadmium 50 mM 48 hrs, 4-day adult  (38) Cadmium 100 mM 48 hrs, 4-day adult  (48) Copper 0.5 mM 12 hrs, larvae L3  (34) Copper 15 mM 48 hrs, 4-day adult  (32) Zinc 5 mM 12 hrs, larvae L3  (28) Zinc 4.5 mM 48 hrs, 4-day adult  (38) Ethanol 2.5% 3 hrs, larvae L3  (62) Ethanol 5% 3 hrs, larvae L3  (29) Ethanol 10% 3 hrs, larvae L3  26 Caffeine 1.5 mg/ml 4 hrs, larvae L3  (30) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (47) Caffeine 25 mg/ml 48 hrs, 4-day adult  (32) Paraquat 5 mM 48 hrs, 4-day adult  (50) Paraquat 10 mM 48 hrs, 4-day adult  (69) Rotenone 2 μg 12 hrs, larvae L3  (31) Rotenone 8 μg 12 hrs, larvae L3  (29) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    36 cold shock, 4-day adult    21 heat shock, 4-day adult    40 Cadmium 50 mM 6 hrs, larvae L3    46 Cadmium 50 mM 12 hrs, larvae L3    24 Cadmium 50 mM 48 hrs, 4-day adult    38 Cadmium 100 mM 48 hrs, 4-day adult    48 Copper 0.5 mM 12 hrs, larvae L3    34 Copper 15 mM 48 hrs, 4-day adult    32 Zinc 5 mM 12 hrs, larvae L3    28 Zinc 4.5 mM 48 hrs, 4-day adult    38 Ethanol 2.5% 3 hrs, larvae L3    62 Ethanol 5% 3 hrs, larvae L3    29 Ethanol 10% 3 hrs, larvae L3    26 Caffeine 1.5 mg/ml 4 hrs, larvae L3    30 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    47 Caffeine 25 mg/ml 48 hrs, 4-day adult    32 Paraquat 5 mM 48 hrs, 4-day adult    50 Paraquat 10 mM 48 hrs, 4-day adult    69 Rotenone 2 μg 12 hrs, larvae L3    31 Rotenone 8 μg 12 hrs, larvae L3    29 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    36 cold shock, 4-day adult    21 heat shock, 4-day adult    40 Cadmium 50 mM 6 hrs, larvae L3    46 Cadmium 50 mM 12 hrs, larvae L3    24 Cadmium 50 mM 48 hrs, 4-day adult    38 Cadmium 100 mM 48 hrs, 4-day adult    48 Copper 0.5 mM 12 hrs, larvae L3    34 Copper 15 mM 48 hrs, 4-day adult    32 Zinc 5 mM 12 hrs, larvae L3    28 Zinc 4.5 mM 48 hrs, 4-day adult    38 Ethanol 2.5% 3 hrs, larvae L3    62 Ethanol 5% 3 hrs, larvae L3    29 Ethanol 10% 3 hrs, larvae L3    26 Caffeine 1.5 mg/ml 4 hrs, larvae L3    30 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    47 Caffeine 25 mg/ml 48 hrs, 4-day adult    32 Paraquat 5 mM 48 hrs, 4-day adult    50 Paraquat 10 mM 48 hrs, 4-day adult    69 Rotenone 2 μg 12 hrs, larvae L3    31 Rotenone 8 μg 12 hrs, larvae L3    29 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    36 cold shock, 4-day adult    21 heat shock, 4-day adult    40 Cadmium 50 mM 6 hrs, larvae L3    46 Cadmium 50 mM 12 hrs, larvae L3    24 Cadmium 50 mM 48 hrs, 4-day adult    38 Cadmium 100 mM 48 hrs, 4-day adult    48 Copper 0.5 mM 12 hrs, larvae L3    34 Copper 15 mM 48 hrs, 4-day adult    32 Zinc 5 mM 12 hrs, larvae L3    28 Zinc 4.5 mM 48 hrs, 4-day adult    38 Ethanol 2.5% 3 hrs, larvae L3    62 Ethanol 5% 3 hrs, larvae L3    29 Ethanol 10% 3 hrs, larvae L3    26 Caffeine 1.5 mg/ml 4 hrs, larvae L3    30 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    47 Caffeine 25 mg/ml 48 hrs, 4-day adult    32 Paraquat 5 mM 48 hrs, 4-day adult    50 Paraquat 10 mM 48 hrs, 4-day adult    69 Rotenone 2 μg 12 hrs, larvae L3    31 Rotenone 8 μg 12 hrs, larvae L3    29 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (36) cold shock, 4-day adult    21 heat shock, 4-day adult  (40) Cadmium 50 mM 6 hrs, larvae L3  (46) Cadmium 50 mM 12 hrs, larvae L3    24 Cadmium 50 mM 48 hrs, 4-day adult  (38) Cadmium 100 mM 48 hrs, 4-day adult  (48) Copper 0.5 mM 12 hrs, larvae L3  (34) Copper 15 mM 48 hrs, 4-day adult  32 Zinc 5 mM 12 hrs, larvae L3  28 Zinc 4.5 mM 48 hrs, 4-day adult  (38) Ethanol 2.5% 3 hrs, larvae L3  (62) Ethanol 5% 3 hrs, larvae L3  29 Ethanol 10% 3 hrs, larvae L3  26 Caffeine 1.5 mg/ml 4 hrs, larvae L3  30 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (47) Caffeine 25 mg/ml 48 hrs, 4-day adult  32 Paraquat 5 mM 48 hrs, 4-day adult  (50) Paraquat 10 mM 48 hrs, 4-day adult  (69) Rotenone 2 μg 12 hrs, larvae L3  31 Rotenone 8 μg 12 hrs, larvae L3  29 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    36 cold shock, 4-day adult    21 heat shock, 4-day adult    40 Cadmium 50 mM 6 hrs, larvae L3    46 Cadmium 50 mM 12 hrs, larvae L3    24 Cadmium 50 mM 48 hrs, 4-day adult    38 Cadmium 100 mM 48 hrs, 4-day adult    48 Copper 0.5 mM 12 hrs, larvae L3    34 Copper 15 mM 48 hrs, 4-day adult    32 Zinc 5 mM 12 hrs, larvae L3    28 Zinc 4.5 mM 48 hrs, 4-day adult    38 Ethanol 2.5% 3 hrs, larvae L3    62 Ethanol 5% 3 hrs, larvae L3    29 Ethanol 10% 3 hrs, larvae L3    26 Caffeine 1.5 mg/ml 4 hrs, larvae L3    30 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    47 Caffeine 25 mg/ml 48 hrs, 4-day adult    32 Paraquat 5 mM 48 hrs, 4-day adult    50 Paraquat 10 mM 48 hrs, 4-day adult    69 Rotenone 2 μg 12 hrs, larvae L3    31 Rotenone 8 μg 12 hrs, larvae L3    29 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    36 cold shock, 4-day adult    21 heat shock, 4-day adult    40 Cadmium 50 mM 6 hrs, larvae L3    46 Cadmium 50 mM 12 hrs, larvae L3    24 Cadmium 50 mM 48 hrs, 4-day adult    38 Cadmium 100 mM 48 hrs, 4-day adult    48 Copper 0.5 mM 12 hrs, larvae L3    34 Copper 15 mM 48 hrs, 4-day adult    32 Zinc 5 mM 12 hrs, larvae L3    28 Zinc 4.5 mM 48 hrs, 4-day adult    38 Ethanol 2.5% 3 hrs, larvae L3    62 Ethanol 5% 3 hrs, larvae L3    29 Ethanol 10% 3 hrs, larvae L3    26 Caffeine 1.5 mg/ml 4 hrs, larvae L3    30 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    47 Caffeine 25 mg/ml 48 hrs, 4-day adult    32 Paraquat 5 mM 48 hrs, 4-day adult    50 Paraquat 10 mM 48 hrs, 4-day adult    69 Rotenone 2 μg 12 hrs, larvae L3    31 Rotenone 8 μg 12 hrs, larvae L3    29 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_26 mE1_20_mRNA_expression_cluster_03
External Data & Images
Linkouts	BDGP expression data • SD08058 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0038376 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG4225-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable Hmt-1LA00983 viable, with Scer\GAL4pnr-MD237 Hmt-1GD3010 Sterility Allele fertile Hmt-1LA00983 Phenotype manifest in Allele
Classical Alleles ( 3 )
For All Classical Alleles Show
Allele of Hmt-1 Class Mutagen Stocks Known lesion Hmt-1LA00983 P-element activity 2 -- Hmt-1EP3387 P-element activity 1 -- Hmt-1NP0283 1 --
Alleles Carried on Transgenic Constructs ( 3 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Hmt-1 Class Mutagen Stocks Known lesion Hmt-1GD3010 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Hmt-1KK101626 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes Hmt-1NIG.4225R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3R)Exel6175 (Ryder, 2004.4.26) Df(3R)Exel8162 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{KK101626} NA P{NIG.4225R} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EP}Hmt-1EP3387 NA P{Mae-UAS.6.11}Hmt-1LA00983 NA insertion of enhancer trap binary system P{GawB}Hmt-1NP0283 No
Gene Ontology: Function, Process & Cellular Component ( 13 unique terms )
Terms Based on Experimental Evidence ( 4 terms )
Molecular Function
CV term Evidence References
NOT cadmium ion transmembrane transporter activity inferred from genetic interaction with GeneDB_Spombe:SPCC737.09c (Sooksa-Nguan et al., 2009)
Biological Process
CV term Evidence References
NOT cadmium ion transmembrane transport inferred from genetic interaction with GeneDB_Spombe:SPCC737.09c (Sooksa-Nguan et al., 2009) response to cadmium ion inferred from genetic interaction with GeneDB_Spombe:SPCC737.09c (Sooksa-Nguan et al., 2009)
Cellular Component
CV term Evidence References
vacuolar membrane inferred from direct assay (Sooksa-Nguan et al., 2009)
Terms Based on Predictions or Assertions ( 9 terms )
Molecular Function
CV term Evidence References
ATPase activity, coupled to transmembrane movement of substances inferred from biological aspect of ancestor with PANTHER:PTN000657188 (assigned by RefGenome) (Gaudet et al., 2010) inferred from sequence or structural similarity with EMBL:AJ003004 (FlyBase, 1992-) inferred from sequence or structural similarity with UniProtKB:Q9NP58 (Sardiello et al., 2003.6.11) ATP binding inferred from electronic annotation with InterPro:IPR001140, InterPro:IPR003439, InterPro:IPR011527, InterPro:IPR017871 (FlyBase Curators et al., 2004-) heme transporter activity inferred from sequence or structural similarity with UniProtKB:Q9NP58 (Sardiello et al., 2003.6.11) transporter activity inferred from sequence or structural similarity with EMBL:AJ003004 (FlyBase, 1992-)
Biological Process
CV term Evidence References
detoxification of cadmium ion inferred from biological aspect of ancestor with PANTHER:PTN000657812 (assigned by RefGenome) (Gaudet et al., 2010) heme transport inferred from sequence or structural similarity with UniProtKB:Q9NP58 (Sardiello et al., 2003.6.11)
Cellular Component
CV term Evidence References
ATP-binding cassette (ABC) transporter complex inferred from sequence or structural similarity with EMBL:AJ003004 (FlyBase, 1992-) integral to membrane inferred from biological aspect of ancestor with PANTHER:PTN000657188 (assigned by RefGenome) (Gaudet et al., 2010) mitochondrial inner membrane inferred from sequence or structural similarity with UniProtKB:Q9NP58 (Sardiello et al., 2003.6.11)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
Hmt-1 - CG5027 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Hmt-1 - Tsp29Fb anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Hmt-1 - nemy anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Hmt-1 allele Gene References CG4225EP3387 pnr (Pena-Rangel et al., 2002) unspecified L (Singh et al., 2005)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 66981 DroID - A comprehensive database of gene and protein interactions. • FBgn0038376 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 41925
Orthologs
OrthoDB Orthologs (41) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG62V91P Dipteran inclusive ortholog search EOG6MCX7D Insect inclusive ortholog search EOG60RZ9N Arthropod inclusive ortholog search EOG6RBP0M Metazoa inclusive ortholog search EOG6DVJDF
Orthologs in Drosophila Species (EOG62V91P)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\Hmt-1     Drosophila simulans   Dsim\GD20321 Y   Drosophila sechellia   Dsec\GM25748 Y   Drosophila erecta   Dere\GG20311 Y   Drosophila yakuba   Dyak\GE26354 Y   Drosophila ananassae   Dana\GF16473 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA18045 Y   Drosophila persimilis   Dper\GL21729 Y   Drosophila willistoni   Dwil\GK11860 Y   Drosophila mojavensis   Dmoj\GI24644 Y   Drosophila grimshawi   Dgri\GH14099 Y
Orthologs in non-Drosophila Dipterans (EOG6MCX7D)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL008134   Anopheles gambiae Malaria mosquito  Agam\AGAP002278   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ018212
Orthologs in non-Dipteran Insects (EOG60RZ9N)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\Hmt-1   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG007737   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH17465   Atta cephalotes Leafcutter ant  Acep\ACEP22179   Camponotus floridanus Florida carpenter ant  Cflo\CFLO22918   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL17708   Linepithema humile Argentine ant  Lhum\LH13937   Linepithema humile Argentine ant  Lhum\LH13933   Linepithema humile Argentine ant  Lhum\LH13935   Pogonomyrmex barbatus Red harvester ant  Pbar\PB17823   Solenopsis invicta Red fire ant  Sinv\SINV10557   Acyrthosiphon pisum Pea aphid  Apim\ACYPI003751   Bombyx mori Silkmoth  Bmor\BGIBMGA005473   Tribolium castaneum Red flour beetle  Tcas\GLEAN_15192
Orthologs in non-Insect Arthropods (EOG6RBP0M)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\COI   Daphnia pulex Water flea  Dpux\Nt5c3l   Ixodes scapularis Deer tick  Isca\ISCW021257
Orthologs in non-Arthropod Metazoa (EOG6DVJDF)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\hmt-1   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_010716gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_018342gn   Danio rerio Zebrafish  Drer\si:dkey-7j20.1   Danio rerio Zebrafish  Drer\abcb6   Xenopus tropicalis Western clawed frog  Xtro\abcb6   Gallus gallus Domestic chicken  Ggal\ABCB6   Mus musculus House mouse  Mmus\Abcb6   Rattus norvegicus Norway rat  Rnor\Abcb6   Homo sapiens Human  Hsap\ABCB6
Human Orthologs (1)
Gene OMIM HGNC Hsap\ABCB6
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD20321 Drosophila sechellia Dsec\GM25748 Drosophila erecta Dere\GG20311 Drosophila yakuba Dyak\GE26354 Drosophila ananassae Dana\GF16473 Drosophila pseudoobscura pseudoobscura Dpse\GA18045 Drosophila persimilis Dper\GL21729 Drosophila willistoni Dwil\GK11860 Drosophila virilis Dvir\GJ23466 Drosophila mojavensis Dmoj\GI24644 Drosophila grimshawi Dgri\GH14099
Stocks & Reagents
Stocks Listed in FlyBase ( 5 )
Bloomington	22259 y1 w*; P{Mae-UAS.6.11}Hmt-1LA00983
Kyoto	109014 w*; P{EP}Hmt-1EP3387 / TM6B, Tb1 120983 y* w*; P{Mae-UAS.6.11}Hmt-1LA00983 103578 y* w*; P{GawB}Hmt-1NP0283 / CyO, P{UAS-lacZ.UW14}UW14
VDRC	v37356 w1118; P{GD3010}v37356
Genomic Clones ( 1 )
	BACR06B08 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 72 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	SD08058
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT01446 AT06960 AT14742 AT22087 RE18896 SD11490
Other clones	28006 31299 33558 82842 118086 214449.49 Dmel_dig_001952_0707_1320 Dmel_neb_014796_0658_1585 EC31655 EK135561 EK140221 EK216160 RP003013576 RP003033119 RP003058694 RP003061870 RP003063041 RP003075301 RP003092275 RP003098444 RP003135027 RP003149788 RP003157618 RP003170109 RP003205138 RP003207999 RP003209844 RP003214917 RP003223209 RP003226631 RP003229316 RP003243505 RP003250361 RP003253474 RP003266214 RP003269246 RP003282337 RP003282858 RP003307126 RP003307431 RP003310862 RP003325202 RP003327532 RP003327813 RP003330460 RP003330687 RP003331618 RP003333237 RP003352907 RP003377707 RP003406980 RP003429392 RP003453621 RP003470180 RP003479914 RP003505641 RP003563635 RP003602706 RP003617444 RP003619546 RP003636618 RP003639561 RP003653778 RP003665989 RP003669226
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0038376 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 41925
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: Hmt-1 CG4225 (Sooksa-Nguan et al., 2009)
Source for database merge of
Additional comments
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_142246 RefSeq (Proteins) • NP_650503 DDBJ / EMBL / GenBank • AAF55241 AAL89947 AI546605 AQ073966 AW944542 AY084209 DU708684 Entrez Gene - A searchable database of RefSeq genes. • 41925 UniProtKB/TrEMBL • Q9VF20
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • ABC transporter, transmembrane domain (IPR001140) ABC transporter-like (IPR003439) AAA+ ATPase domain (IPR003593) ABC transporter, transmembrane domain, type 1 (IPR011527) P-loop containing nucleoside triphosphate hydrolase (IPR027417) ABC transporter, conserved site (IPR017871) ABC transporter, integral membrane type 1 (IPR017940) MitoDrome - A database of annotated Dmel nuclear genes encoding mitochondrial proteins • MTDROME04225 BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • SD08058
Linkouts
	BioGRID - A database of protein and genetic interactions • 66981 DroID - A comprehensive database of gene and protein interactions. • FBgn0038376 DRSC - Results from RNAi screens. • FBgn0038376 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0038376 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG4225-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0038376 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 41925 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 41925 modMine - Data generated by the modENCODE project. • FBgn0038376
Synonyms & Secondary IDs ( 6 )
Reported As
Symbol Synonym	CG4225 (Ricardo and Lehmann, 2009, Mayer et al., 2009, Keleman et al., 2009.8.5, Cammarato et al., 2011, Bridon et al., 2012, Japanese National Institute of Genetics, 2012.5.21) EP(3)3387 (Pena-Rangel et al., 2002) Hmt-1 (Bridon et al., 2012) hmt-1 (Sooksa-Nguan et al., 2009)
Name Synonym	CG4225   Heavy metal tolerance factor 1   heavy metal tolerance factor 1 (Sooksa-Nguan et al., 2009)
Secondary FlyBase IDs
References ( 29 )
Generate a list of	All references relating to this gene ( 29 )
List References by type	Research paper  ( 5 ) Supplementary material  ( 7 ) Review  ( 1 ) Personal communication to FlyBase  ( 9 ) FlyBase analysis  ( 2 ) Stock list  ( 1 ) Website  ( 2 ) Curated genome annotation  ( 2 )
Recent research papers ( 1 )
	Bridon et al., 2012, J. Proteome Res. 11(2): 927--940 Improvement of Phosphoproteome Analyses Using FAIMS and Decision Tree Fragmentation. Application to the Insulin Signaling Pathway in Drosophila melanogaster S2 Cells. [FBrf0217365] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...