FlyBase Gene Report: Dmel\sxe2

General Information

Symbol

Dmel\sxe2

Species

D. melanogaster

Name

sex-specific enzyme 2

Annotation Symbol

CG4979

Feature Type

protein_coding_gene

FlyBase ID

FBgn0038398

Gene Model Status

Current

Stock Availability

3 publicly available

Gene Summary

Contribute a Gene Snapshot for this gene.

All Summaries

Alliance
Auto summary
Gene Group
Interactive Fly

Key Links

Genomic Location

Cytogenetic map

89B2-89B3

Sequence location

3R:16,083,878..16,087,222 [+]

Recombination map

3-58

RefSeq locus

NT_033777 REGION:16083878..16087222

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse GBrowse

Help me choose

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

GO Summary Ribbons

Gene Ontology (GO) Annotations (4 terms)

Molecular Function (2 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

enables serine hydrolase activity

inferred from high throughput direct assay

(Kumar et al., 2021)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

enables lipase activity

inferred from biological aspect of ancestor with PANTHER:PTN000176726

(assigned by GO_Central )

(Gaudet et al., 2011)

Biological Process (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

involved_in lipid catabolic process

inferred from biological aspect of ancestor with PANTHER:PTN000176726

(assigned by GO_Central )

(Gaudet et al., 2011)

Cellular Component (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

is_active_in extracellular space

inferred from biological aspect of ancestor with PANTHER:PTN000176726

(assigned by GO_Central )

(Gaudet et al., 2011)

Gene Group (FlyBase)

NEUTRAL TRIGLYCERIDE LIPASES

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Gene Group (FlyBase)

NEUTRAL TRIGLYCERIDE LIPASES -: Lipases, generally defined as triacylglycerol hydrolases (EC 3.1.1.3), cleave the carboxylester linkages in triacylglycerol (TAG) to produce diacylglycerol (DAG) and a carboxylate. In insects, TAGs are used for energy storage and for storage of fatty acid precursors for semiochemicals, while DAGs are the main form of transported lipid. Lipases thus control key steps in lipid uptake, transport and utilisation. The neutral lipases are so named for their ability to hydrolyse neutral lipids such as TAGs, DAGs and monoacylglycerols (MAGs), though members of this family are also known to hydrolyse the sn-1 position in phospholipids and galactolipids. Neutral lipases are defined by Pfam domain PF00151 (corresponding to InterPro IPR013818). (Adapted from FBrf0208359.)

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\sxe2 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure New Section

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q9VEY9)

If you don't see the viewer to the right, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Comments on Gene Model

Gene model reviewed during 5.47

Gene model reviewed during 5.55

Sequence Ontology: Class of Gene

nuclear_gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

sxe2-RA

FBtr0083225

NM_142265

1583

387

sxe2-RB

FBtr0345306

NM_001300423

1627

387

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank

sxe2-PA

FBpp0082679

42.4

387

8.75

NP_650522

AAF55273

sxe2-PB

FBpp0311471

42.4

387

8.75

NP_001287352

AHN57351

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

387 aa isoforms: sxe2-PA, sxe2-PB

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Q9VEY9

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\sxe2 using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

sxe2_1

Linkouts

Expression Data

Expression Summary Ribbons

Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.

For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.

Transcript Expression

expression microarray

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult fat body

Comment: cyclical, peak ZT1-4

(Xu et al., 2011)

RT-PCR

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult fat body

Comment: cyclical, peak ZT4

(Erion et al., 2016)

Additional Descriptive Data

Expressed cyclically in the adult fat body.

(Xu et al., 2011)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\sxe2 in GBrowse 2

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\sxe2

View exonic expression by tissue for Dmel\sxe2

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0038398

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

41954/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0038398

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0038398

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0038398

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG4979

Flygut - An atlas of the Drosophila adult midgut

FBgn0038398

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 0 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 4 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of sxe2

Transgenic constructs containing regulatory region of sxe2

Aberrations (Deficiencies and Duplications) ( 2 )

Inferred from experimentation ( 2 )

Gene disrupted in

Df(3R)ΔMhcl

(Bonn et al., 2013)

Df(3R)Exel7328

(Ryder, 2004.4.26)

Inferred from location ( 0 )

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

sxe2^GD5705

viable, with Scer\GAL4^Mef2.PR

sxe2^GD5705

viable, with Scer\GAL4^pnr-MD237

sxe2^GD5705

Phenotype manifest in

Allele

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v8.0)

Homo sapiens (Human) (10)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Hsap\PLA1A

4 of 15

Yes

3 of 15

3 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

1 of 15

1 of 15

Model Organism Orthologs (via DIOPT v8.0)

Mus musculus (laboratory mouse) (9)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Mmus\Pla1a

4 of 15

Yes

3 of 15

3 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

1 of 15

Rattus norvegicus (Norway rat) (9)

Rnor\Lipi

3 of 13

Yes

Rnor\Pla1a

2 of 13

Yes

2 of 13

2 of 13

2 of 13

1 of 13

1 of 13

1 of 13

Yes

Rnor\Lpl

1 of 13

Xenopus tropicalis (Western clawed frog) (6)

Xtro\liph

3 of 12

Yes

2 of 12

2 of 12

2 of 12

1 of 12

1 of 12

Danio rerio (Zebrafish) (8)

Drer\lipia

3 of 15

Yes

Drer\lipib

3 of 15

Yes

2 of 15

2 of 15

2 of 15

1 of 15

1 of 15

1 of 15

Caenorhabditis elegans (Nematode, roundworm) (0)

No records found.

Arabidopsis thaliana (thale-cress) (0)

No records found.

Saccharomyces cerevisiae (Brewer's yeast) (0)

No records found.

Schizosaccharomyces pombe (Fission yeast) (0)

No records found.

Other Organism Orthologs (via OrthoDB)

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v8.0)

Drosophila melanogaster (Fruit fly) (32)

Gene Symbol

Score

Source

Alignment

3 of 10

3 of 10

3 of 10

3 of 10

3 of 10

3 of 10

3 of 10

3 of 10

3 of 10

3 of 10

3 of 10

3 of 10

3 of 10

3 of 10

3 of 10

3 of 10

3 of 10

3 of 10

3 of 10

3 of 10

Yp1

3 of 10

Yp2

3 of 10

Yp3

3 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

1 of 10

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Model Summary Ribbon

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

PLA1A; phospholipase A1 member A

4 of 15

607460

LIPH; lipase H

3 of 15

607365

HYPOTRICHOSIS 7; HYPT7

hypotrichosis 7

LIPI; lipase I

3 of 15

609252

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Interactions Browser

Summary of Genetic Interactions

esyN Network Diagram

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0038398

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyCyc Pathways - Pathways from a BioCyc PGDB for Dmel

phospholipases

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0038398

External Data

Linkouts

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

3-58

Cytogenetic map

89B2-89B3

Sequence location

3R:16,083,878..16,087,222 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

89B2-89B3

Limits computationally determined from genome sequence between P{PZ}blp⁰¹⁶¹⁸ and P{PZ}gish⁰⁴⁸⁹⁵&P{EP}EP3171

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

3-58

(FlyBase, 2016)

3-58.1

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (3)

Aberrations including deletions of this gene Aberrations including duplications of this gene

FlyORF

F003519

M{UAS-sxe2.ORF.3xHA.GW}ZH-86Fb

VDRC

v100331

P{KK105952}VIE-260B

v38064

w¹¹¹⁸; P{GD5705}v38064

Genomic Clones (15)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (17)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

GH15759

Other clones

DPiM_GH15759

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0038398

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

GH05003

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0038398

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

41954

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Other Information

Relationship to Other Genes

Source for database identify of

Source for identity of: sxe2 CG4979

(Fujii and Amrein, 2002)

Source for database merge of

Additional comments

Other Comments

Origin and Etymology

Discoverer

Etymology

Identification

External Crossreferences and Linkouts ( 37 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

41954

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q9VEY9

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Q9VEY9

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q9VEY9

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0038398

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0038398

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

41954/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0038398

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

sxe2_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0038398

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0038398

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG4979

Flygut - An atlas of the Drosophila adult midgut

FBgn0038398

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0038398

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

41954

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

Dmel_CG4979

MARRVEL_MODEL - MARRVEL (model organism gene)

41954

modMine - A data warehouse for the modENCODE project

FBgn0038398

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0038398

DRSC - Results frm RNAi screens

FBgn0038398

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0038398

FlyCyc Pathways - Pathways from a BioCyc PGDB for Dmel

phospholipases

FlyMine - An integrated database for Drosophila genomics

FBgn0038398

Synonyms and Secondary IDs (5)

Reported As

Symbol Synonym

CG4979

(Palu and Thummel, 2016, Horne et al., 2009, Keleman et al., 2009.8.5, Goldman and Arbeitman, 2007, Fujii and Amrein, 2002, Tzolovsky et al., 2002)

Sxe2

(Ahmed and Vogel, 2020)

sxe2

(Kumar et al., 2021, Wang et al., 2021, Li et al., 2020, Barber et al., 2016, Japanese National Institute of Genetics, 2012.5.21, Xu et al., 2011, Fernández-Ayala et al., 2010, Kong et al., 2010, Horne et al., 2009, Goldman and Arbeitman, 2007, Ranz et al., 2004)

Name Synonyms

male sex-specific enzyme 2

(Fernández-Ayala et al., 2010)

sex-specific enzyme 2

(Goldman and Arbeitman, 2007, Fujii and Amrein, 2002)

Secondary FlyBase IDs

Datasets (2)

Study focus (0)

Experimental Role

Project

Project Type

Title