FB2021_06, released December 14, 2021

Gene: Dmel\Zip89B

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General Information
Symbol
Dmel\Zip89B
Species
D. melanogaster
Name
Zinc/iron regulated transporter-related protein 89B
Annotation Symbol
CG6898
Feature Type
protein_coding_gene
FlyBase ID
FBgn0038412
Gene Model Status
Current
Stock Availability
3 publicly available
Gene Summary
Zinc/iron regulated transporter-related protein 89B (Zip89B) encodes a protein involved in zinc detoxification and zinc transmembrane import. [Date last reviewed: 2019-09-12] (FlyBase Gene Snapshot)
All Summaries
Also Known As

dZip89B, Zip3

Key Links
Genomic Location
Cytogenetic map
89B12-89B12
Sequence location
Recombination map
3-58
RefSeq locus
NT_033777 REGION:16305758..16308700
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (6 terms)
Molecular Function (1 term)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
enables zinc ion transmembrane transporter activity
inferred from biological aspect of ancestor with PANTHER:PTN000115815
(assigned by GO_Central )
(Gaudet et al., 2011)
inferred by curator from GO:0016324
(Lye et al., 2013)
Biological Process (2 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
involved_in detoxification of zinc ion
inferred from mutant phenotype
(Lye et al., 2013)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
involved_in zinc ion transmembrane transport
inferred from biological aspect of ancestor with PANTHER:PTN000115815
(assigned by GO_Central )
(Gaudet et al., 2011)
Cellular Component (3 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
located_in apical plasma membrane
inferred from direct assay
(Lye et al., 2013)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
is_active_in membrane
inferred from biological aspect of ancestor with PANTHER:PTN000115815
(assigned by GO_Central )
(Gaudet et al., 2011)
is_active_in plasma membrane
inferred from biological aspect of ancestor with PANTHER:PTN000113378
(assigned by GO_Central )
(Gaudet et al., 2011)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Gene Snapshot
Zinc/iron regulated transporter-related protein 89B (Zip89B) encodes a protein involved in zinc detoxification and zinc transmembrane import. [Date last reviewed: 2019-09-12]
Gene Group (FlyBase)
SLC39 FAMILY OF ZINC ION TRANSPORTERS -
Solute carrier family 39 (SLC39) or Zinc-Iron Permeases (ZIP) transport Zn2+ across the membrane into the cytosol, either from the extracellular space or from the lumen of intracellular organelles. (Adapted from FBrf0220942).
Gene Model and Products
Number of Transcripts
1
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\Zip89B for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Gene model reviewed during 5.47

Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Zip89B-RA
FBtr0083266
NM_080499
2011
495
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
Zip89B-PA
FBpp0082720
54.3
495
6.05
NP_536747
AAF55295
Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Zip89B using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in apical plasma membrane
inferred from direct assay
(Lye et al., 2013)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Zip89B in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 1 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 7 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Zip89B
Transgenic constructs containing regulatory region of Zip89B
Aberrations (Deficiencies and Duplications) ( 2 )
Alleles Representing Disease-Implicated Variants
Phenotypes
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (3)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\SLC39A1
9 of 15
Yes
Yes
1  
Hsap\SLC39A2
8 of 15
No
Yes
Hsap\SLC39A3
8 of 15
No
No
2  
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (3)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Slc39a1
9 of 15
Yes
Yes
Mmus\Slc39a3
9 of 15
Yes
No
Mmus\Slc39a2
7 of 15
No
No
Rattus norvegicus (Norway rat) (3)
Rnor\Slc39a3
7 of 13
Yes
No
Rnor\Slc39a2
6 of 13
No
Yes
Rnor\Slc39a1
5 of 13
No
Yes
Xenopus tropicalis (Western clawed frog) (4)
Xtro\slc39a3
8 of 12
Yes
No
Xtro\slc39a1
5 of 12
No
Yes
Xtro\slc39a1
5 of 12
No
Yes
Xtro\slc39a2
5 of 12
No
Yes
Danio rerio (Zebrafish) (2)
Drer\slc39a1
10 of 15
Yes
Yes
Drer\slc39a3
6 of 15
No
Yes
Caenorhabditis elegans (Nematode, roundworm) (6)
Cele\zipt-2.2
11 of 15
Yes
Yes
Cele\zipt-1
10 of 15
No
Yes
Cele\zipt-2.4
10 of 15
No
Yes
Cele\zipt-2.1
9 of 15
No
Yes
Cele\zipt-2.3
9 of 15
No
Yes
Cele\zipt-3
4 of 15
No
No
Arabidopsis thaliana (thale-cress) (14)
Atha\ZIP2
5 of 9
Yes
No
Atha\IRT1
4 of 9
No
Yes
Atha\IRT3
4 of 9
No
Yes
Atha\ZIP3
4 of 9
No
Yes
Atha\ZIP4
4 of 9
No
Yes
Atha\ZIP5
4 of 9
No
Yes
Atha\ZIP11
4 of 9
No
No
Atha\IRT2
3 of 9
No
Yes
Atha\ZIP1
3 of 9
No
No
Atha\ZIP6
3 of 9
No
Yes
Atha\ZIP7
3 of 9
No
Yes
Atha\ZIP9
3 of 9
No
Yes
Atha\ZIP10
3 of 9
No
Yes
Atha\ZIP12
3 of 9
No
No
Saccharomyces cerevisiae (Brewer's yeast) (3)
Scer\ZRT2
7 of 15
Yes
Yes
Scer\ZRT1
6 of 15
No
Yes
Scer\ATX2
1 of 15
No
No
Schizosaccharomyces pombe (Fission yeast) (1)
Spom\zrt1
7 of 12
Yes
Yes
Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG09190B1O )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00010329
Drosophila simulans
Dsim\GD19087
Drosophila sechellia
Dsec\GM15144
Drosophila erecta
Dere\GG16992
Drosophila yakuba
Dyak\GE24385
Drosophila ananassae
Dana\GF18487
Drosophila pseudoobscura pseudoobscura
Dpse\GA19939
Drosophila persimilis
Dper\GL21597
Drosophila willistoni
Dwil\GK13772
Drosophila virilis
Dvir\GJ23722
Drosophila mojavensis
Dmoj\GI22942
Drosophila grimshawi
Dgri\GH19543
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091505BG )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17027551
Glossina morsitans
Tsetse fly
Gmor\GMOY006513
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_02665
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL001626
Anopheles darlingi
American malaria mosquito
Adar\ADAC009030
Anopheles gambiae
Malaria mosquito
Agam\AGAP011178
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ003167
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W057S )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA005005
Danaus plexippus
Monarch butterfly
Dple\DPOGS211330-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS211328-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL016477
Heliconius melpomene
Postman butterfly
Hmel\HMEL016475
Apis florea
Little honeybee
Aflo\3088098612
Apis mellifera
Western honey bee
Amel\GB48310
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP19108
Linepithema humile
Argentine ant
Lhum\LH20653
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:00170d
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG001139
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_12348
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_12347
Tribolium castaneum
Red flour beetle
Tcas\TC002943
Tribolium castaneum
Red flour beetle
Tcas\TC032396
Pediculus humanus
Human body louse
Phum\PHUM332550
Pediculus humanus
Human body louse
Phum\PHUM596950
Rhodnius prolixus
Kissing bug
Rpro\ZIP3
Rhodnius prolixus
Kissing bug
Rpro\ZIP
Cimex lectularius
Bed bug
Clec\CLEC006355
Cimex lectularius
Bed bug
Clec\CLEC006354
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI009434
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI36810
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI069597
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_09385
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_09384
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X0548 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Ixodes scapularis
Black-legged tick
Isca\ISCW015984
Stegodyphus mimosarum
African social velvet spider
Smim\KFM65516.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur04g01370
Tetranychus urticae
Two-spotted spider mite
Turt\tetur04g01340
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_32841
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( None identified )
No non-Arthropod Metazoa orthologies identified
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (4)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
Zip42C.1
9 of 10
Zip42C.2
9 of 10
Zip88E
6 of 10
Zip48C
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    SLC39A1; solute carrier family 39 member 1
    9 of 15
    604740
         
        SLC39A2; solute carrier family 39 member 2
        8 of 15
        612166
            SLC39A3; solute carrier family 39 member 3
            8 of 15
            612168
                 
                Functional Complementation Data
                Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
                Interactions
                Summary of Physical Interactions
                esyN Network Diagram
                Interactions Browser
                Summary of Genetic Interactions
                esyN Network Diagram
                esyN Network Key:
                Suppression
                Enhancement
                View in Interactions Browser
                Please look at the allele data for full details of the genetic interactions
                Starting gene(s)
                Interaction type
                Interacting gene(s)
                Reference
                Zip89B
                enhanceable
                foi
                (Richards et al., 2015)
                Zip89B
                enhanceable
                Zip42C.1
                (Richards et al., 2015)
                Zip89B
                enhanceable
                Zip42C.2
                (Richards et al., 2015)
                Zip89B
                enhanceable
                ZnT41F
                (Richards et al., 2015)
                Zip89B
                enhanceable
                ZnT63C
                (Richards et al., 2015)
                Starting gene(s)
                Interaction type
                Interacting gene(s)
                Reference
                Zip42C.1|ZnT63C
                suppressible
                Zip89B
                (Lye et al., 2013)
                Zip71B
                enhanceable
                Zip89B
                (Dechen et al., 2015)
                ZnT86D
                enhanceable
                Zip89B
                (Dechen et al., 2015)
                ZnT86D
                suppressible
                Zip89B
                (Dechen et al., 2015)
                External Data
                Linkouts
                DroID - A comprehensive database of gene and protein interactions.
                MIST (genetic) - An integrated Molecular Interaction Database
                Pathways
                Signaling Pathways (FlyBase)
                Metabolic Pathways
                FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.
                External Data
                Linkouts
                Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                Genomic Location and Detailed Mapping Data
                Chromosome (arm)
                3R
                Recombination map
                3-58
                Cytogenetic map
                89B12-89B12
                Sequence location
                FlyBase Computed Cytological Location
                Cytogenetic map
                Evidence for location
                89B12-89B12
                Limits computationally determined from genome sequence between P{PZ}gish04895&P{EP}EP3171 and P{lacW}CSN5L4032
                Experimentally Determined Cytological Location
                Cytogenetic map
                Notes
                References
                Experimentally Determined Recombination Data
                Location

                3-58

                (FlyBase, 2016)

                3-58.3

                (Comeron et al., 2012)
                Left of (cM)
                Right of (cM)
                Notes
                Stocks and Reagents
                Stocks (3)
                Genomic Clones (15)
                 

                Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

                cDNA Clones (53)
                 

                Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

                cDNA clones, fully sequenced
                BDGP DGC clones
                Other clones
                Drosophila Genomics Resource Center cDNA clones

                For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

                cDNA Clones, End Sequenced (ESTs)
                BDGP DGC clones
                Other clones
                RNAi and Array Information
                Linkouts
                DRSC - Results frm RNAi screens
                GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                Antibody Information
                Laboratory Generated Antibodies
                 
                Commercially Available Antibodies
                 
                Other Information
                Relationship to Other Genes
                Source for database identify of

                Source for identity of: ZIP3 CG6898

                (FlyBase, 1996-)

                Source for identity of: Zip89B Zip3

                (Lye et al., 2012)
                Source for database merge of
                Additional comments

                Source for identity of ZIP3 CG6898 was sequence comparison ( date:001123 ).

                (FlyBase, 1996-)
                Other Comments
                Origin and Etymology
                Discoverer
                Etymology
                Identification
                External Crossreferences and Linkouts ( 35 )
                Sequence Crossreferences
                NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
                Other crossreferences
                Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
                DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
                EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
                Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
                FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
                Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
                Flygut - An atlas of the Drosophila adult midgut
                FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.
                GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
                InterPro - A database of protein families, domains and functional sites
                KEGG Genes - Molecular building blocks of life in the genomic space.
                MARRVEL_MODEL - MARRVEL (model organism gene)
                modMine - A data warehouse for the modENCODE project
                Linkouts
                DroID - A comprehensive database of gene and protein interactions.
                DRSC - Results frm RNAi screens
                FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
                FlyMine - An integrated database for Drosophila genomics
                MIST (genetic) - An integrated Molecular Interaction Database
                Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                Synonyms and Secondary IDs (13)
                Datasets (0)
                Study focus (0)
                Experimental Role
                Project
                Project Type
                Title
                References (40)