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Gene Dmel\Brf

General Information
Symbol	Dmel\Brf	Species	D. melanogaster
Name	Brf	Annotation symbol	CG31256
Feature type	protein_coding_gene	FlyBase ID	FBgn0038499
Gene Model Status	Current	Stock availability	11 publicly available
Genomic Location
Chromosome (arm)	3R	Recombination map
Cytogenetic map	90A3-90A5	Sequence location	3R:13,200,555..13,217,054 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Brf is referred to in FlyBase by the symbol Dmel\Brf (CG31256, FBgn0038499). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: transcription factor binding; core promoter sequence-specific DNA binding. There is experimental evidence that it is involved in the biological process: regulation of transcription from RNA polymerase III promoter; transcription from RNA polymerase III promoter. 9 alleles are reported. No phenotypic data is available. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: Brf1-like TBP-binding; Cyclin-like; Transcription factor TFIIB; Transcription factor TFIIB, cyclin-related; Zinc finger, TFIIB-type. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 00-12 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval central nervous system, larval carcass. Comments on Affy2 ProbeSet: ProbeSet 1626187_at completely aligns to an exonic region of only a subset of 1 of the 2 FlyBase-annotated transcript isoforms of Brf. Gene sequence location is 3R:13200555..13217054.
External Summaries
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2012_01	Sequence features HFA14167 HFA14166 BKN23074 Controlled Vocabulary Terms core promoter sequence-specific DNA binding transcription from RNA polymerase III promoter
FB2011_10
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 90A3-90A5   Limits computationally determined from genome sequence between P{EP}CG5208EP562&P{EP}DadEP3196 and P{PZ}l(3)0788207882
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Brf for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Brf-RA FBtr0083452  NM_142359   2970   662 Brf-RB FBtr0302317  NM_001170165   2257   662
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Brf-PA   FBpp0082893   73.6   662   4.74     NP_650616   AAF55409 Brf-PB   FBpp0291523   73.6   662   4.74     NP_001163636   ACZ94932
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Transcription factor TFIIB (IPR000812) Brf1-like TBP-binding (IPR011665) Zinc finger, TFIIB-type (IPR013137) Transcription factor TFIIB, cyclin-related (IPR013150) Cyclin-like (IPR013763)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA949837   AA951545   AE014297 AAF55409   AE014297 ACZ94932   AF262374 AAF72065   AF262375 AAF72066   AI534204   AW943121   AY051811 AAK93235   BF491465   BF494486   BG635158   BG635572   BI165616   BI212501   BI228521   BI236800   BI240937   BI632810   CL527689   CO188426   CO295203   CO297209   CO340936   CZ471297   CZ481146   EC201625   EC202791   EC226678   EV592514   GH961601   GH980989
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9NB72 Q9NG52 Q9VEL2
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference adult stage   mushroom body | restricted   (Kobayashi et al., 2006)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0038499    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0038499 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 00-12 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0038499 expression level Developmental Stage   Expression Level embryo 00-02hr    1962 embryo 02-04hr    2036 embryo 04-06hr    1901 embryo 06-08hr    2141 embryo 08-10hr    1757 embryo 10-12hr    1331 embryo 12-14hr    1163 embryo 14-16hr    907 embryo 16-18hr    798 embryo 18-20hr    709 embryo 20-22hr    913 embryo 22-24hr    844 larva L1    682 larva L2    579 larva L3 12hr old    442 larva L3 puffstage 1-2    537 larva L3 puffstage 3-6    843 larva L3 puffstage 7-9    1096 white prepupae new    1207 white prepupae 12hr    1123 white prepupae 24hr    1288 pupae 2d postWPP    899 pupae 3d postWPP    480 pupae 4d postWPP    336 adult male 01day    394 adult male 05day    470 adult male 30day    407 adult female 01day    619 adult female 05day    932 adult female 30day    947 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (1962) embryo 02-04hr  (2036) embryo 04-06hr  (1901) embryo 06-08hr  (2141) embryo 08-10hr  (1757) embryo 10-12hr  (1331) embryo 12-14hr  (1163) embryo 14-16hr  (907) embryo 16-18hr  (798) embryo 18-20hr  (709) embryo 20-22hr  (913) embryo 22-24hr  (844) larva L1  (682) larva L2  (579) larva L3 12hr old  (442) larva L3 puffstage 1-2  (537) larva L3 puffstage 3-6  (843) larva L3 puffstage 7-9  (1096) white prepupae new  (1207) white prepupae 12hr  (1123) white prepupae 24hr  (1288) pupae 2d postWPP  (899) pupae 3d postWPP  (480) pupae 4d postWPP  (336) adult male 01day  (394) adult male 05day  (470) adult male 30day  (407) adult female 01day  (619) adult female 05day  (932) adult female 30day  (947) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (1962) embryo 02-04hr  (2036) embryo 04-06hr  (1901) embryo 06-08hr  (2141) embryo 08-10hr  (1757) embryo 10-12hr    1331 embryo 12-14hr    1163 embryo 14-16hr    907 embryo 16-18hr    798 embryo 18-20hr    709 embryo 20-22hr    913 embryo 22-24hr    844 larva L1    682 larva L2    579 larva L3 12hr old    442 larva L3 puffstage 1-2    537 larva L3 puffstage 3-6    843 larva L3 puffstage 7-9    1096 white prepupae new    1207 white prepupae 12hr    1123 white prepupae 24hr    1288 pupae 2d postWPP    899 pupae 3d postWPP    480 pupae 4d postWPP    336 adult male 01day    394 adult male 05day    470 adult male 30day    407 adult female 01day    619 adult female 05day    932 adult female 30day    947 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    1962 embryo 02-04hr    2036 embryo 04-06hr    1901 embryo 06-08hr    2141 embryo 08-10hr    1757 embryo 10-12hr    1331 embryo 12-14hr    1163 embryo 14-16hr    907 embryo 16-18hr    798 embryo 18-20hr    709 embryo 20-22hr    913 embryo 22-24hr    844 larva L1    682 larva L2    579 larva L3 12hr old    442 larva L3 puffstage 1-2    537 larva L3 puffstage 3-6    843 larva L3 puffstage 7-9    1096 white prepupae new    1207 white prepupae 12hr    1123 white prepupae 24hr    1288 pupae 2d postWPP    899 pupae 3d postWPP    480 pupae 4d postWPP    336 adult male 01day    394 adult male 05day    470 adult male 30day    407 adult female 01day    619 adult female 05day    932 adult female 30day    947 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    1962 embryo 02-04hr    2036 embryo 04-06hr    1901 embryo 06-08hr    2141 embryo 08-10hr    1757 embryo 10-12hr    1331 embryo 12-14hr    1163 embryo 14-16hr    907 embryo 16-18hr    798 embryo 18-20hr    709 embryo 20-22hr    913 embryo 22-24hr    844 larva L1    682 larva L2    579 larva L3 12hr old    442 larva L3 puffstage 1-2    537 larva L3 puffstage 3-6    843 larva L3 puffstage 7-9    1096 white prepupae new    1207 white prepupae 12hr    1123 white prepupae 24hr    1288 pupae 2d postWPP    899 pupae 3d postWPP    480 pupae 4d postWPP    336 adult male 01day    394 adult male 05day    470 adult male 30day    407 adult female 01day    619 adult female 05day    932 adult female 30day    947 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0038499 expression level Developmental Stage   Expression Level embryo 00-02hr    1962 embryo 02-04hr    2036 embryo 04-06hr    1901 embryo 06-08hr    2141 embryo 08-10hr    1757 embryo 10-12hr    1331 embryo 12-14hr    1163 embryo 14-16hr    907 embryo 16-18hr    798 embryo 18-20hr    709 embryo 20-22hr    913 embryo 22-24hr    844 larva L1    682 larva L2    579 larva L3 12hr old    442 larva L3 puffstage 1-2    537 larva L3 puffstage 3-6    843 larva L3 puffstage 7-9    1096 white prepupae new    1207 white prepupae 12hr    1123 white prepupae 24hr    1288 pupae 2d postWPP    899 pupae 3d postWPP    480 pupae 4d postWPP    336 adult male 01day    394 adult male 05day    470 adult male 30day    407 adult female 01day    619 adult female 05day    932 adult female 30day    947 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (1962) embryo 02-04hr  (2036) embryo 04-06hr  (1901) embryo 06-08hr  (2141) embryo 08-10hr  (1757) embryo 10-12hr  (1331) embryo 12-14hr  (1163) embryo 14-16hr  (907) embryo 16-18hr  (798) embryo 18-20hr  (709) embryo 20-22hr  (913) embryo 22-24hr  (844) larva L1  (682) larva L2  (579) larva L3 12hr old  (442) larva L3 puffstage 1-2  (537) larva L3 puffstage 3-6  (843) larva L3 puffstage 7-9  (1096) white prepupae new  (1207) white prepupae 12hr  (1123) white prepupae 24hr  (1288) pupae 2d postWPP  (899) pupae 3d postWPP  (480) pupae 4d postWPP  (336) adult male 01day  (394) adult male 05day  (470) adult male 30day  (407) adult female 01day  (619) adult female 05day  (932) adult female 30day  (947) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  1962 embryo 02-04hr  2036 embryo 04-06hr  1901 embryo 06-08hr  2141 embryo 08-10hr  1757 embryo 10-12hr    1331 embryo 12-14hr    1163 embryo 14-16hr    907 embryo 16-18hr    798 embryo 18-20hr    709 embryo 20-22hr    913 embryo 22-24hr    844 larva L1    682 larva L2    579 larva L3 12hr old    442 larva L3 puffstage 1-2    537 larva L3 puffstage 3-6    843 larva L3 puffstage 7-9    1096 white prepupae new    1207 white prepupae 12hr    1123 white prepupae 24hr    1288 pupae 2d postWPP    899 pupae 3d postWPP    480 pupae 4d postWPP    336 adult male 01day    394 adult male 05day    470 adult male 30day    407 adult female 01day    619 adult female 05day    932 adult female 30day    947 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    1962 embryo 02-04hr    2036 embryo 04-06hr    1901 embryo 06-08hr    2141 embryo 08-10hr    1757 embryo 10-12hr    1331 embryo 12-14hr    1163 embryo 14-16hr    907 embryo 16-18hr    798 embryo 18-20hr    709 embryo 20-22hr    913 embryo 22-24hr    844 larva L1    682 larva L2    579 larva L3 12hr old    442 larva L3 puffstage 1-2    537 larva L3 puffstage 3-6    843 larva L3 puffstage 7-9    1096 white prepupae new    1207 white prepupae 12hr    1123 white prepupae 24hr    1288 pupae 2d postWPP    899 pupae 3d postWPP    480 pupae 4d postWPP    336 adult male 01day    394 adult male 05day    470 adult male 30day    407 adult female 01day    619 adult female 05day    932 adult female 30day    947 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    1962 embryo 02-04hr    2036 embryo 04-06hr    1901 embryo 06-08hr    2141 embryo 08-10hr    1757 embryo 10-12hr    1331 embryo 12-14hr    1163 embryo 14-16hr    907 embryo 16-18hr    798 embryo 18-20hr    709 embryo 20-22hr    913 embryo 22-24hr    844 larva L1    682 larva L2    579 larva L3 12hr old    442 larva L3 puffstage 1-2    537 larva L3 puffstage 3-6    843 larva L3 puffstage 7-9    1096 white prepupae new    1207 white prepupae 12hr    1123 white prepupae 24hr    1288 pupae 2d postWPP    899 pupae 3d postWPP    480 pupae 4d postWPP    336 adult male 01day    394 adult male 05day    470 adult male 30day    407 adult female 01day    619 adult female 05day    932 adult female 30day    947 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0038499    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0038499 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval central nervous system, larval carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0038499 expression level Tissue   Expression Level Larval Central Nervous System    180.9 Larval Midgut    54.8 Larval Hindgut    71.4 Larval Malpighian Tubules    94.9 Larval Fat Body    93.2 Larval Salivary Gland no informative data Larval Trachea    62.075 Larval Carcass    104.55 Adult Head    61.3 Adult Eye    58.1 Adult Brain    95.4 Adult Thoracic-Abdominal Ganglion    99.9 Adult Crop    90.3 Adult Midgut    51.7 Adult Hindgut    52.3 Adult Malpighian Tubules    68.6 Adult Fat Body    42.4 Adult Salivary Gland no informative data Adult Heart    36.85 Adult VirginFemale Spermatheca    47.7 Adult InseminatedFemale Spermatheca    58.3 Adult Ovary    94.4 Adult Testis    8.7 Adult Male Accessory Gland no informative data Adult Carcass    50.2 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    180.9 Larval Midgut    54.8 Larval Hindgut    71.4 Larval Malpighian Tubules    94.9 Larval Fat Body    93.2 Larval Salivary Gland no informative data Larval Trachea    62.075 Larval Carcass    104.55 Adult Head    61.3 Adult Eye    58.1 Adult Brain    95.4 Adult Thoracic-Abdominal Ganglion    99.9 Adult Crop    90.3 Adult Midgut    51.7 Adult Hindgut    52.3 Adult Malpighian Tubules    68.6 Adult Fat Body    42.4 Adult Salivary Gland no informative data Adult Heart    36.85 Adult VirginFemale Spermatheca    47.7 Adult InseminatedFemale Spermatheca    58.3 Adult Ovary    94.4 Adult Testis    8.7 Adult Male Accessory Gland no informative data Adult Carcass    50.2 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    180.9 Larval Midgut    54.8 Larval Hindgut    71.4 Larval Malpighian Tubules    94.9 Larval Fat Body    93.2 Larval Salivary Gland no informative data Larval Trachea    62.075 Larval Carcass    104.55 Adult Head    61.3 Adult Eye    58.1 Adult Brain    95.4 Adult Thoracic-Abdominal Ganglion    99.9 Adult Crop    90.3 Adult Midgut    51.7 Adult Hindgut    52.3 Adult Malpighian Tubules    68.6 Adult Fat Body    42.4 Adult Salivary Gland no informative data Adult Heart    36.85 Adult VirginFemale Spermatheca    47.7 Adult InseminatedFemale Spermatheca    58.3 Adult Ovary    94.4 Adult Testis    8.7 Adult Male Accessory Gland no informative data Adult Carcass    50.2 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    180.9 Larval Midgut    54.8 Larval Hindgut    71.4 Larval Malpighian Tubules    94.9 Larval Fat Body    93.2 Larval Salivary Gland no informative data Larval Trachea    62.075 Larval Carcass    104.55 Adult Head    61.3 Adult Eye    58.1 Adult Brain    95.4 Adult Thoracic-Abdominal Ganglion    99.9 Adult Crop    90.3 Adult Midgut    51.7 Adult Hindgut    52.3 Adult Malpighian Tubules    68.6 Adult Fat Body    42.4 Adult Salivary Gland no informative data Adult Heart    36.85 Adult VirginFemale Spermatheca    47.7 Adult InseminatedFemale Spermatheca    58.3 Adult Ovary    94.4 Adult Testis    8.7 Adult Male Accessory Gland no informative data Adult Carcass    50.2 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0038499 expression level Tissue   Expression Level Larval Central Nervous System    180.9 Larval Midgut    54.8 Larval Hindgut    71.4 Larval Malpighian Tubules    94.9 Larval Fat Body    93.2 Larval Salivary Gland no informative data Larval Trachea    62.075 Larval Carcass    104.55 Adult Head    61.3 Adult Eye    58.1 Adult Brain    95.4 Adult Thoracic-Abdominal Ganglion    99.9 Adult Crop    90.3 Adult Midgut    51.7 Adult Hindgut    52.3 Adult Malpighian Tubules    68.6 Adult Fat Body    42.4 Adult Salivary Gland no informative data Adult Heart    36.85 Adult VirginFemale Spermatheca    47.7 Adult InseminatedFemale Spermatheca    58.3 Adult Ovary    94.4 Adult Testis    8.7 Adult Male Accessory Gland no informative data Adult Carcass    50.2 Expression Level Scale  None   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    180.9 Larval Midgut    54.8 Larval Hindgut    71.4 Larval Malpighian Tubules    94.9 Larval Fat Body    93.2 Larval Salivary Gland no informative data Larval Trachea    62.075 Larval Carcass    104.55 Adult Head    61.3 Adult Eye    58.1 Adult Brain    95.4 Adult Thoracic-Abdominal Ganglion    99.9 Adult Crop    90.3 Adult Midgut    51.7 Adult Hindgut    52.3 Adult Malpighian Tubules    68.6 Adult Fat Body    42.4 Adult Salivary Gland no informative data Adult Heart    36.85 Adult VirginFemale Spermatheca    47.7 Adult InseminatedFemale Spermatheca    58.3 Adult Ovary    94.4 Adult Testis    8.7 Adult Male Accessory Gland no informative data Adult Carcass    50.2 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    180.9 Larval Midgut    54.8 Larval Hindgut    71.4 Larval Malpighian Tubules    94.9 Larval Fat Body    93.2 Larval Salivary Gland no informative data Larval Trachea    62.075 Larval Carcass    104.55 Adult Head    61.3 Adult Eye    58.1 Adult Brain    95.4 Adult Thoracic-Abdominal Ganglion    99.9 Adult Crop    90.3 Adult Midgut    51.7 Adult Hindgut    52.3 Adult Malpighian Tubules    68.6 Adult Fat Body    42.4 Adult Salivary Gland no informative data Adult Heart    36.85 Adult VirginFemale Spermatheca    47.7 Adult InseminatedFemale Spermatheca    58.3 Adult Ovary    94.4 Adult Testis    8.7 Adult Male Accessory Gland no informative data Adult Carcass    50.2 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    180.9 Larval Midgut    54.8 Larval Hindgut    71.4 Larval Malpighian Tubules    94.9 Larval Fat Body    93.2 Larval Salivary Gland no informative data Larval Trachea    62.075 Larval Carcass    104.55 Adult Head    61.3 Adult Eye    58.1 Adult Brain    95.4 Adult Thoracic-Abdominal Ganglion    99.9 Adult Crop    90.3 Adult Midgut    51.7 Adult Hindgut    52.3 Adult Malpighian Tubules    68.6 Adult Fat Body    42.4 Adult Salivary Gland no informative data Adult Heart    36.85 Adult VirginFemale Spermatheca    47.7 Adult InseminatedFemale Spermatheca    58.3 Adult Ovary    94.4 Adult Testis    8.7 Adult Male Accessory Gland no informative data Adult Carcass    50.2 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland no informative data Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland no informative data Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland no informative data Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    61.3   NA  Eye    58.1   NA  Brain    95.4   180.9  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    99.9   NA  Crop    90.3   54.8  Midgut    51.7   71.4  Hindgut    52.3   94.9  Malpighian Tubules    68.6   93.2  Fat Body    42.4   no informative data  Salivary Gland    no informative data   NA  Heart    36.85   62.075  Trachea    NA   NA  VirginFemale Spermatheca    47.7   NA  InseminatedFemale Spermatheca    58.3   NA  Ovary    94.4   NA  Testis    8.7   NA  Male Accessory Gland    no informative data   104.55  Carcass    50.2 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_30
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0038499 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG31256-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for Brf Stages(s) 1-3 Stages(s) 4-6 Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal, with Scer\GAL41407 BrfGD10207 lethal | pupal stage, with Scer\GAL4pnr-MD237 BrfGD10207 lethal | recessive Brfc07161 Phenotype manifest in Allele embryonic/larval brain | larval stage, with Scer\GAL41407 BrfGD10207
Classical Alleles ( 5 )
For All Classical Alleles Show
Allele of Brf Class Mutagen Stocks Known lesion Brfc07161 piggyBac transposase 2 -- Brfe03376 piggyBac transposase 1 -- BrfEY02964 P-element activity 1 -- BrfMI02107 1 -- BrfNP7061 1 --
Alleles Carried on Transgenic Constructs ( 4 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Brf Class Mutagen Stocks Known lesion BrfGD10207 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes BrfGL00467 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes BrfJF02482 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes BrfKK104802 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD10207} NA P{KK104802} NA P{TRiP.GL00467} NA P{TRiP.JF02482} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EPgy2}BrfEY02964 NA P{GSV1}C923C923 NA miscellaneous insertions Mi{MIC}BrfMI02107 NA PBac{PB}Brfc07161 NA PBac{RB}Brfe03376 NA insertion of enhancer trap binary system P{GawB}BrfNP7061 No
Gene Ontology: Function, Process & Cellular Component ( 12 unique terms )
Terms Based on Experimental Evidence ( 5 terms )
Molecular Function
CV term Evidence References
contributes_to core promoter sequence-specific DNA binding inferred from physical interaction with Trf (Isogai et al., 2007) transcription factor binding inferred from physical interaction with Trf (Takada et al., 2000)
Biological Process
CV term Evidence References
regulation of transcription from RNA polymerase III promoter inferred from direct assay AND inferred from physical interaction with Trf (Takada et al., 2000) transcription from RNA polymerase III promoter inferred from direct assay (Takada et al., 2000)
Cellular Component
CV term Evidence References
transcription factor complex inferred from physical interaction with Trf (Takada et al., 2000)
Terms Based on Predictions or Assertions ( 8 terms )
Molecular Function
CV term Evidence References
translation initiation factor activity inferred from electronic annotation with InterPro:IPR013150 (FlyBase Curators et al., 2004-) zinc ion binding inferred from electronic annotation with InterPro:IPR000812, InterPro:IPR011665, InterPro:IPR013137 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
positive regulation of transcription, DNA-dependent inferred from electronic annotation with InterPro:IPR011665 (FlyBase Curators et al., 2004-) regulation of transcription from RNA polymerase III promoter inferred from sequence or structural similarity with UniProtKB:P46070 (FlyBase, 1992-) transcription initiation, DNA-dependent inferred from electronic annotation with InterPro:IPR000812 (FlyBase Curators et al., 2004-) translational initiation inferred from electronic annotation with InterPro:IPR013150 (FlyBase Curators et al., 2004-)
Cellular Component
CV term Evidence References
nucleus non-traceable author statement (Takada, 2000.5.1) transcription factor TFIIIB complex inferred from sequence or structural similarity with UniProtKB:P43072 (FlyBase, 1992-)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Brf allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 67124 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0038499 DroID - A comprehensive database of gene and protein interactions. • FBgn0038499 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 42087
Orthologs
Genome-wide drosophilid orthologs	Dana\GF16885 Dere\GG16780 Dgri\GH17498 Dmoj\GI22827 Dper\GL23944 Dpse\GA16127 Dsec\GM15370 Dsim\GD20238 Dvir\GJ22828 Dwil\GK11456 Dyak\GE24172
Curated drosophilid orthologs	Dpse\GA16127
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL002427-PB Aedes aegypti (mosquito) AGAP004233-PA Anopheles gambiae (mosquito) XP_623775.2 Apis mellifera (honey bee) XP_001950065.1 Acyrthosiphon pisum (pea aphid) At3g09360.1 Arabidopsis thaliana (wall cress) 24490 Batrachochytrium dendrobatidis (chytrid fungus) XP_001896547.1 Brugia malayi (roundworm nematode) BGIBMGA005062-PA Bombyx mori (silk worm) ENSBTAP00000041784 Bos taurus (bovine) CAL0004048 Candida albicans (a form of yeast) CN12508 Caenorhabditis brenneri (small nematode) CBP27227 Caenorhabditis briggsae (nematode) CE02738 Caenorhabditis elegans (worm) ENSCAFP00000027187 Canis familiaris (dog) Chro.50018 Cryptosporidium hominis (obligate parasite) ENSCINP00000008644 Ciona intestinalis (sea squirt) JA09052 Caenorhabditis japonica (nematode) CMA019C Cyanidioschyzon merolae (red alga) cn06405 Cryptococcus neoformans (yeast-like fungus) cgd5_3540 Cryptosporidium parvum (protozoan parasite) CPIJ008270 Culex pipens (mosquito) ENSCPOP00000000059 Cavia porcellus (guinea pig) RP40397 Caenorhabditis remanei (nematode) ENSCSAVP00000012256 Ciona savignyi (sedentary tunicate) DDB0231089 Dictyostelium discoideum (amoeba) DEHA2G23738g Debaryomyces Hansenii (yeast) 304854 Daphnia pulex (daphnia) ENSDARP00000038308 Danio rerio (zebra fish) ENSECAP00000016277 Equus caballus (horse) XP_650799 Entamoeba histolytica (anaerobic protozoan) ENSGACP00000018063 Gymnopilus aculeatus (mushroom) ENSGALP00000019108 Gallus gallus (chicken) 193467 Hypsipyla robusta (cedar shoot borer) ENSP00000329029 Homo sapiens (human) ISCW011301-PA Ixodes scapularis (deer tick) KLLA0A05434g Kluyveromyces lactis (yeast) 166871 Lottia gigantea (owl limpet) ENSMODP00000032133 Monodelphis domestica (gray opossum) ENSMUSP00000011302 Mus musculus (house mouse) 147404 Nematostella vectensis (starlet anemone) XP_001607399.1 Nasonia vitripennis (wasp) ENSOANP00000017610 Ornithorynchus anatinus (platypus) ENSORLP00000022756 Oryzias latipes (japanese killifish) LOC_Os05g23940.1 Oryza sativa (asian rice) 24390 Ostreococcus tauri (green alga) PF14_0469 Plasmodium falciparum (protozoal parasite) PHUM009866-PA Pediculus humanus (human body louse) PP16964 Pristionchus pacificus (nematode) ENSPPYP00000007048 Pongo pygmaeus (orangutan) 81220 Phytophthora ramorum (sudden oak death pathogen) 136707 Phytophthora sojae (root rot pathogen) 203528 Populus trichocarpa (black cottonwood) ENSPTRP00000011599 Pan troglodytes (chimpanzee) PVX_118025 Plasmodium vivax (protozoal parasite) ENSRNOP00000019689 Rattus norvegicus (norway rat) 5060879 Sorghum bicolor (sorghum) YGR246C Saccharomyces cerevisiae (budding yeast) Smp_071570 Schistosoma mansoni (trematode parasite) SPBC13E7.10c Schizosaccharomyces pombe (fission yeast) XP_794011.2 Strongylocentrotus purpuratus (purple sea urchin) 62066 Trichoplax adhaerens (metazoa) TA04210 Theileria annulata (apicomplexan parasite) XP_973702.2 Tribolium castaneum (red flour beetle) Tc00.1047053507093.180 Trypanosoma cruzi (parasitic trypanosome) ENSTNIP00000007462 Tetraodon nigroviridis (green spotted pufferfish) TP03_0376 Theileria parva (parasitic protozoan) 2130 Thalassiosira pseudonana (marine diatom) ENSTRUP00000041459 Takifugu rubripes (pufferfish Takifugu) 3681.m00087 Tetrahymena thermophila (ciliate protozoa) 84950.m00099 Trichomonas vaginalis (parasitic flagellated protozoan) ENSXETP00000048818 Xenopus tropicalis (frog) YALI0E24035g Yarrowia lipolytica (nonconventional yeast) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV12861 LH19293 LH19291 ISCW011301 FBgn0241303 FBgn0213467 FBgn0209932 FBgn0191715 FBgn0170289 JGI_V11_304854 FBgn0076143 FBgn0161534 FBgn0145554 FBgn0124968 FBgn0109010 FBgn0093905 CPIJ008273 CPIJ008270 BGIBMGA005061 BGIBMGA005062 ACYPI002062 GB14903 AGAP004233 AAEL002427 PB24145 PB24146 PHUM452440 PHUM452470 GLEAN_09572 GLEAN_09573
Stocks & Reagents
Stocks Listed in FlyBase ( 11 )
Bloomington	29321 y1 v1; P{TRiP.JF02482}attP2 35623 y1 sc* v1; P{TRiP.GL00467}attP2 17804 w1118; PBac{PB}Brfc07161/TM6B, Tb1 34277 y1 w*; Mi{MIC}BrfMI02107/TM3, Sb1 Ser1 16544 y1 w67c23; P{EPgy2}BrfEY02964/TM3, Sb1 Ser1
Harvard	- PBac{PB}Brfc07161 - PBac{RB}Brfe03376
Kyoto	105352 y* w*; P{GawB}BrfNP7061 / TM6C, Sb1
VDRC	v100122 P{KK104802}VIE-260B v40218 w1118; P{GD10207}v40218 v40219 w1118; P{GD10207}v40219/TM3
Genomic Clones ( 2 )
	BACR29H07 BACR48C05 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 24 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD32109
Other clones	DPiM_LD32109
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT03109 AT28211 AT31651 LD29874 RE05545 RE17603 RE26082 RE32920 RE37903 SD06780 SD13024 SD26684
Other clones	79266 108228 157014 Dmel_neb_009820_0646_0731 EK040125 EK208917 EK216406 EP11609 RP004237160 RP004534114
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0038499 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 42087
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: Brf CG4155 CG5419 (FlyBase, 1996-)
Source for database merge of
Additional comments	FlyBase curator comment: the insertion in the "e00975" Exelixis line (PBac{RB}sds22e00975) was originally assigned to the Brf gene in FBrf0179797, resulting in the "Brfe00975" (FBal0162762) allele. However, FBrf0184340 shows that the insertion is actually within sds22. (Bloomington Drosophila Stock Center, 2004.11.6) Annotations CG4155, CG5419 merged as CG31256 in release 3 of the genome annotation. (FlyBase Genome Annotators, 2002-2003) Source for identity of Brf CG4155 CG5419 was sequence comparison (date:000529). (FlyBase, 1996-)
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_142359 NM_001170165 RefSeq (Proteins) • NP_650616 NP_001163636 DDBJ / EMBL / GenBank • AA951545 AAF55409 AAF72065 AAF72066 AAK93235 ACZ94932 AF262374 AF262375 AW943121 AY051811 CL527689 CZ471297 CZ481146 Entrez Gene - A searchable database of RefSeq genes. • 42087 UniProtKB/TrEMBL • Q9NB72 Q9NG52 Q9VEL2
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Transcription factor TFIIB (IPR000812) Brf1-like TBP-binding (IPR011665) Zinc finger, TFIIB-type (IPR013137) Transcription factor TFIIB, cyclin-related (IPR013150) Cyclin-like (IPR013763)
Linkouts
	BioGRID - A database of protein and genetic interactions • 67124 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0038499 DroID - A comprehensive database of gene and protein interactions. • FBgn0038499 DRSC - Results from RNAi screens. • FBgn0038499 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0038499 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG31256-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0038499 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 42087 InParanoid A subset of ortholog calls from InParanoid. • AAEL002427-PB Aedes aegypti (mosquito) AGAP004233-PA Anopheles gambiae (mosquito) XP_623775.2 Apis mellifera (honey bee) XP_001950065.1 Acyrthosiphon pisum (pea aphid) At3g09360.1 Arabidopsis thaliana (wall cress) 24490 Batrachochytrium dendrobatidis (chytrid fungus) XP_001896547.1 Brugia malayi (roundworm nematode) BGIBMGA005062-PA Bombyx mori (silk worm) ENSBTAP00000041784 Bos taurus (bovine) CAL0004048 Candida albicans (a form of yeast) CN12508 Caenorhabditis brenneri (small nematode) CBP27227 Caenorhabditis briggsae (nematode) CE02738 Caenorhabditis elegans (worm) ENSCAFP00000027187 Canis familiaris (dog) Chro.50018 Cryptosporidium hominis (obligate parasite) ENSCINP00000008644 Ciona intestinalis (sea squirt) JA09052 Caenorhabditis japonica (nematode) CMA019C Cyanidioschyzon merolae (red alga) cn06405 Cryptococcus neoformans (yeast-like fungus) cgd5_3540 Cryptosporidium parvum (protozoan parasite) CPIJ008270 Culex pipens (mosquito) ENSCPOP00000000059 Cavia porcellus (guinea pig) RP40397 Caenorhabditis remanei (nematode) ENSCSAVP00000012256 Ciona savignyi (sedentary tunicate) DDB0231089 Dictyostelium discoideum (amoeba) DEHA2G23738g Debaryomyces Hansenii (yeast) 304854 Daphnia pulex (daphnia) ENSDARP00000038308 Danio rerio (zebra fish) ENSECAP00000016277 Equus caballus (horse) XP_650799 Entamoeba histolytica (anaerobic protozoan) ENSGACP00000018063 Gymnopilus aculeatus (mushroom) ENSGALP00000019108 Gallus gallus (chicken) 193467 Hypsipyla robusta (cedar shoot borer) ENSP00000329029 Homo sapiens (human) ISCW011301-PA Ixodes scapularis (deer tick) KLLA0A05434g Kluyveromyces lactis (yeast) 166871 Lottia gigantea (owl limpet) ENSMODP00000032133 Monodelphis domestica (gray opossum) ENSMUSP00000011302 Mus musculus (house mouse) 147404 Nematostella vectensis (starlet anemone) XP_001607399.1 Nasonia vitripennis (wasp) ENSOANP00000017610 Ornithorynchus anatinus (platypus) ENSORLP00000022756 Oryzias latipes (japanese killifish) LOC_Os05g23940.1 Oryza sativa (asian rice) 24390 Ostreococcus tauri (green alga) PF14_0469 Plasmodium falciparum (protozoal parasite) PHUM009866-PA Pediculus humanus (human body louse) PP16964 Pristionchus pacificus (nematode) ENSPPYP00000007048 Pongo pygmaeus (orangutan) 81220 Phytophthora ramorum (sudden oak death pathogen) 136707 Phytophthora sojae (root rot pathogen) 203528 Populus trichocarpa (black cottonwood) ENSPTRP00000011599 Pan troglodytes (chimpanzee) PVX_118025 Plasmodium vivax (protozoal parasite) ENSRNOP00000019689 Rattus norvegicus (norway rat) 5060879 Sorghum bicolor (sorghum) YGR246C Saccharomyces cerevisiae (budding yeast) Smp_071570 Schistosoma mansoni (trematode parasite) SPBC13E7.10c Schizosaccharomyces pombe (fission yeast) XP_794011.2 Strongylocentrotus purpuratus (purple sea urchin) 62066 Trichoplax adhaerens (metazoa) TA04210 Theileria annulata (apicomplexan parasite) XP_973702.2 Tribolium castaneum (red flour beetle) Tc00.1047053507093.180 Trypanosoma cruzi (parasitic trypanosome) ENSTNIP00000007462 Tetraodon nigroviridis (green spotted pufferfish) TP03_0376 Theileria parva (parasitic protozoan) 2130 Thalassiosira pseudonana (marine diatom) ENSTRUP00000041459 Takifugu rubripes (pufferfish Takifugu) 3681.m00087 Tetrahymena thermophila (ciliate protozoa) 84950.m00099 Trichomonas vaginalis (parasitic flagellated protozoan) ENSXETP00000048818 Xenopus tropicalis (frog) YALI0E24035g Yarrowia lipolytica (nonconventional yeast) Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /genebrief/brf.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 42087 modMine - Data generated by the modENCODE project. • FBgn0038499 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV12861 LH19293 LH19291 ISCW011301 FBgn0241303 FBgn0213467 FBgn0209932 FBgn0191715 FBgn0170289 JGI_V11_304854 FBgn0076143 FBgn0161534 FBgn0145554 FBgn0124968 FBgn0109010 FBgn0093905 CPIJ008273 CPIJ008270 BGIBMGA005061 BGIBMGA005062 ACYPI002062 GB14903 AGAP004233 AAEL002427 PB24145 PB24146 PHUM452440 PHUM452470 GLEAN_09572 GLEAN_09573
Synonyms & Secondary IDs ( 8 )
Reported As
Symbol Synonym	Brf (Steiger et al., 2008, Kobayashi et al., 2006, Molnar et al., 2006, Grewal et al., 2007, Bury et al., 2008, Avet-Rochex et al., 2010) BRF (Isogai et al., 2007, Hochheimer and Tjian, 2003, Takada et al., 2000) BRF1 (Berk, 2000) CG4155   CG5419   CG31256 (Molnar et al., 2006, Keleman et al., 2009.8.5, Perkins et al., 2009, Ni et al., 2011.7.19) TFIIIB (Mueller and Tora, 2004)
Name Synonym	Brf (Steiger et al., 2008) RNA Pol III transcription factor (Cho et al., 2005)
Secondary FlyBase IDs
	FBgn0038502 FBgn0051256
References ( 34 )
Generate a list of	All references relating to this gene ( 34 )
List References by type	Research paper  ( 10 ) Supplementary material  ( 3 ) Review  ( 3 ) Personal communication to FlyBase  ( 7 ) FlyBase analysis  ( 4 ) DNA/RNA sequence record  ( 1 ) Computer file  ( 3 ) Automatic genome annotation  ( 1 ) Curated genome annotation  ( 2 )
Recent research papers ( 1 )
	Avet-Rochex et al., 2010, BMC Dev. Biol. 10: 65 An in vivo RNA interference screen identifies gene networks controlling Drosophila melanogaster blood cell homeostasis. [FBrf0211137] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...