FB2020_06, released Dec 22, 2020

Gene: Dmel\Sur-8

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General Information
Symbol
Dmel\Sur-8
Species
D. melanogaster
Name
Sur-8
Annotation Symbol
CG5407
Feature Type
protein_coding_gene
FlyBase ID
FBgn0038504
Gene Model Status
Current
Stock Availability
12 publicly available
Gene Snapshot
Contributions welcome
Other Summaries
Key Links
Genomic Location
Cytogenetic map
90A5-90A5
Sequence location
3R:17,395,199..17,402,515 [-]
Recombination map

3-60

RefSeq locus
NT_033777 REGION:17395199..17402515
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (2 terms)
Molecular Function (0 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (0 terms)
Biological Process (2 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
involved_in positive regulation of Ras protein signal transduction
inferred from high throughput genetic interaction with FLYBASE:Ras85D; FB:FBgn0003205
(Ashton-Beaucage et al., 2014)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
involved_in positive regulation of Ras protein signal transduction
inferred from biological aspect of ancestor with PANTHER:PTN002907940
(assigned by GO_Central )
(Gaudet et al., 2011)
involved_in signal transduction
inferred from biological aspect of ancestor with PANTHER:PTN002907714
(assigned by GO_Central )
(Gaudet et al., 2011)
Cellular Component (0 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (0 terms)
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the SHOC2 family. (Q9VEK6)
Protein Signatures (InterPro)
Summaries
Protein Function (UniProtKB)
Acts as a Ras effector and participates in MAPK pathway activation. Probably acts as a regulatory subunit of protein phosphatase that specifically dephosphorylates Raf kinase and stimulate Raf activity at specialized signaling complexes upon Ras activation (By similarity).
(UniProt, Q9VEK6)
Gene Model and Products
Number of Transcripts
4
Number of Unique Polypeptides
2

Please see the JBrowse view of Dmel\Sur-8 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Stop-codon suppression (UGA) postulated; FBrf0216884.

Gene model reviewed during 5.44

gene_with_stop_codon_read_through ; SO:0000697

Gene model reviewed during 5.46

Gene model reviewed during 5.49

Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated

Sequence Ontology: Class of Gene
gene_with_stop_codon_read_through
(Jungreis et al., 2011)
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Sur-8-RA
FBtr0083447
NM_169758
4537
641
Sur-8-RB
FBtr0083448
NM_142363
4309
641
Sur-8-RE
FBtr0339531
NM_001275736
4537
694
Sur-8-RF
FBtr0339532
NM_001275735
2842
641
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
Sur-8-PA
FBpp0082888
69.4
641
7.23
NP_732231
AAF55415
Sur-8-PB
FBpp0082889
69.4
641
7.23
NP_650620
AAN13743
Sur-8-PE
FBpp0308614
74.7
694
7.07
NP_001262665
AGB96045
Sur-8-PF
FBpp0308615
69.4
641
7.23
NP_001262664
AGB96044
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

641 aa isoforms: Sur-8-PA, Sur-8-PB, Sur-8-PF
Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Nucleotide / Polypeptide Records
 
UniProt
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Sur-8 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Sur-8 in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 8 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 8 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Sur-8
Transgenic constructs containing regulatory region of Sur-8
Deletions and Duplications ( 0 )
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4Mef2.PR
viable, with Scer\GAL4pnr-MD237
viable, with Scer\GAL4tin.CΔ4
viable (with Df(3R)ED5780)
Phenotype manifest in
Allele
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (5)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\SHOC2
14 of 15
Yes
Yes
Hsap\LRRC57
1 of 15
No
No
Hsap\LRRIQ4
1 of 15
No
Yes
Hsap\PHLPP1
1 of 15
No
No
Hsap\PHLPP2
1 of 15
No
No
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (6)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Shoc2
13 of 15
Yes
Yes
Mmus\Lrrc57
1 of 15
No
No
Mmus\Lrrd1
1 of 15
No
Yes
Mmus\Lrriq4
1 of 15
No
Yes
Mmus\Phlpp1
1 of 15
No
No
Mmus\Phlpp2
1 of 15
No
No
Rattus norvegicus (Norway rat) (5)
Rnor\Shoc2
11 of 13
Yes
Yes
Rnor\LOC100910478
1 of 13
No
No
Rnor\Lrrc57
1 of 13
No
No
Rnor\Lrrd1
1 of 13
No
Yes
Rnor\Lrriq4
1 of 13
No
Yes
Xenopus tropicalis (Western clawed frog) (9)
Xtro\shoc2
8 of 12
Yes
Yes
Xtro\LOC100170560
1 of 12
No
Yes
Xtro\LOC100485206
1 of 12
No
Yes
Xtro\LOC100489423
1 of 12
No
No
Xtro\LOC100490082
1 of 12
No
Yes
Xtro\LOC101733155
1 of 12
No
No
Xtro\lrrc32.2
1 of 12
No
Yes
Xtro\lrrc57
1 of 12
No
No
Xtro\lrriq4
1 of 12
No
Yes
Danio rerio (Zebrafish) (8)
Drer\shoc2
12 of 15
Yes
Yes
Drer\lrrc8da
1 of 15
No
Yes
Drer\lrrc18a
1 of 15
No
Yes
Drer\lrrc57
1 of 15
No
No
Drer\mxra5b
1 of 15
No
Yes
Drer\si:ch211-106h11.1
1 of 15
No
Yes
Drer\si:ch211-210p4.6
1 of 15
No
Yes
Drer\si:zfos-323e3.4
1 of 15
No
Yes
Caenorhabditis elegans (Nematode, roundworm) (4)
Cele\soc-2
13 of 15
Yes
Yes
Cele\lron-14
1 of 15
No
Yes
Cele\phlp-2
1 of 15
No
No
Cele\ZK546.2
1 of 15
No
No
Arabidopsis thaliana (thale-cress) (17)
Atha\AT3G15410
3 of 9
Yes
No
Atha\PIRL1
2 of 9
No
Yes
Atha\PIRL2
2 of 9
No
Yes
Atha\PIRL3
2 of 9
No
Yes
Atha\PIRL4
2 of 9
No
Yes
Atha\PIRL5
2 of 9
No
Yes
Atha\PIRL8
2 of 9
No
No
Atha\PIRL9
2 of 9
No
Yes
Atha\AT1G15740
1 of 9
No
No
Atha\AT1G61180
1 of 9
No
Yes
Atha\AT1G73066
1 of 9
No
Yes
Atha\AT3G24240
1 of 9
No
No
Atha\AT5G48770
1 of 9
No
Yes
Atha\PIRL6
1 of 9
No
No
Atha\PIRL7
1 of 9
No
No
Atha\RLP29
1 of 9
No
Yes
Atha\SNC1
1 of 9
No
Yes
Saccharomyces cerevisiae (Brewer's yeast) (2)
Scer\CYR1
2 of 15
Yes
No
Scer\SOG2
1 of 15
No
No
Schizosaccharomyces pombe (Fission yeast) (2)
Spom\cyr1
3 of 12
Yes
No
Spom\SPBC887.09c
1 of 12
No
No
Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG09190680 )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00008285
Drosophila simulans
Dsim\GD20236
Drosophila sechellia
Dsec\GM15368
Drosophila erecta
Dere\GG16778
Drosophila yakuba
Dyak\GE24170
Drosophila ananassae
Dana\GF16883
Drosophila pseudoobscura pseudoobscura
Dpse\GA27118
Drosophila persimilis
Dper\GL23942
Drosophila willistoni
Dwil\GK11454
Drosophila virilis
Dvir\GJ22826
Drosophila mojavensis
Dmoj\GI25779
Drosophila grimshawi
Dgri\GH17496
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG0915041Z )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17006180
Glossina morsitans
Tsetse fly
Gmor\GMOY008600
Mayetiola destructor
Hessian fly
Mdes\Mdes000801
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL014718
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL009928
Anopheles darlingi
American malaria mosquito
Adar\ADAC009713
Anopheles gambiae
Malaria mosquito
Agam\AGAP004485
Culex quinquefasciatus
Southern house mosquito
Cqui\Sur-8
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W03TV )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA006403
Danaus plexippus
Monarch butterfly
Dple\DPOGS210974-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL025025
Apis florea
Little honeybee
Aflo\2253640292
Apis mellifera
Western honey bee
Amel\GB49571
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP24116
Bombus terrestris
Buff-tailed bumblebee
Bter\15215905
Linepithema humile
Argentine ant
Lhum\LH13548
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:002bde
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG010492
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_11768
Tribolium castaneum
Red flour beetle
Tcas\TC011315
Pediculus humanus
Human body louse
Phum\PHUM104030
Rhodnius prolixus
Kissing bug
Rpro\RPRC008459
Cimex lectularius
Bed bug
Clec\CLEC025252
Cimex lectularius
Bed bug
Clec\CLEC011970
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI060662
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_16569
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X03R5 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR002748
Ixodes scapularis
Black-legged tick
Isca\ISCW005645
Stegodyphus mimosarum
African social velvet spider
Smim\KFM76013.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM76463.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur27g00390
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_315899
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G05NZ )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Shoc2
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000004971
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000018834
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000004411
Gallus gallus
Domestic chicken
Ggal\SHOC2
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (13)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
Phlpp
3 of 10
CG11099
2 of 10
CG32687
2 of 10
f-cup
2 of 10
Lrch
2 of 10
CG3040
1 of 10
CG3408
1 of 10
CG3494
1 of 10
CG7800
1 of 10
CG10307
1 of 10
ics
1 of 10
Lrr47
1 of 10
ltl
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 1 )
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    SHOC2; SHOC2 leucine rich repeat scaffold protein
    14 of 15
    602775
    Functional Complementation Data
    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
    Interactions
    Summary of Physical Interactions
    esyN Network Diagram
    Show neighbor-neighbor interactions:
    Select Layout:
    Legend:
    Protein
    RNA
    Selected Interactor(s)
    Interactions Browser
    View in Interactions Browser
    Please see the Physical Interaction reports below for full details
    protein-protein
    Physical Interaction
    Assay
    References
    Sur-8 - Pp1-87B
    anti tag coimmunoprecipitation, anti tag western blot
    (Xue et al., 2019)
    Sur-8 - per
    anti bait coimmunoprecipitation, anti tag western blot, anti tag coimmunoprecipitation, western blot
    (Xue et al., 2019)
    Summary of Genetic Interactions
    esyN Network Diagram
    esyN Network Key:
    Suppression
    Enhancement
    View in Interactions Browser
    Please look at the allele data for full details of the genetic interactions
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    pbl
    suppressible
    Sur-8
    (Gregory et al., 2007)
    External Data
    Linkouts
    BioGRID - A database of protein and genetic interactions.
    DroID - A comprehensive database of gene and protein interactions.
    InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
    MIST (protein-protein) - An integrated Molecular Interaction Database
    Pathways
    Signaling Pathways (FlyBase)
    Metabolic Pathways
    External Data
    Linkouts
    Genomic Location and Detailed Mapping Data
    Chromosome (arm)
    3R
    Recombination map

    3-60

    Cytogenetic map
    90A5-90A5
    Sequence location
    3R:17,395,199..17,402,515 [-]
    FlyBase Computed Cytological Location
    Cytogenetic map
    Evidence for location
    90A5-90A5
    Limits computationally determined from genome sequence between P{EP}CG5208EP562&P{EP}DadEP3196 and P{PZ}l(3)0788207882
    Experimentally Determined Cytological Location
    Cytogenetic map
    Notes
    References
    Experimentally Determined Recombination Data
    Location

    3-60

    (FlyBase, 2016)

    3-59.6

    (Comeron et al., 2012)
    Left of (cM)
    Right of (cM)
    Notes
    Stocks and Reagents
    Stocks (12)
    Genomic Clones (15)
     

    Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

    cDNA Clones (186)
     

    Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

    cDNA clones, fully sequenced
    BDGP DGC clones
    Other clones
      Drosophila Genomics Resource Center cDNA clones

      For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

      cDNA Clones, End Sequenced (ESTs)
      BDGP DGC clones
      Other clones
      RNAi and Array Information
      Linkouts
      DRSC - Results frm RNAi screens
      GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
      Antibody Information
      Laboratory Generated Antibodies
       
      Commercially Available Antibodies
       
      Other Information
      Relationship to Other Genes
      Source for database identify of

      Source for identity of: Sur-8 CG5407

      (Hynes and Zhao, 2000)
      Source for database merge of
      Additional comments
      Other Comments

      dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.

      (Kiger et al., 2003)
      Origin and Etymology
      Discoverer
      Etymology
      Identification
      External Crossreferences and Linkouts ( 50 )
      Sequence Crossreferences
      NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
      GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
      GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
      RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
      UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
      UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
      Other crossreferences
      Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
      Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
      Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
      Flygut - An atlas of the Drosophila adult midgut
      GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
      iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
      InterPro - A database of protein families, domains and functional sites
      KEGG Genes - Molecular building blocks of life in the genomic space.
      modMine - A data warehouse for the modENCODE project
      Linkouts
      BioGRID - A database of protein and genetic interactions.
      DroID - A comprehensive database of gene and protein interactions.
      DRSC - Results frm RNAi screens
      FLIGHT - Cell culture data for RNAi and other high-throughput technologies
      FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
      FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
      FlyMine - An integrated database for Drosophila genomics
      InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
      MIST (protein-protein) - An integrated Molecular Interaction Database
      Synonyms and Secondary IDs (5)
      Datasets (0)
      Study focus (0)
      Experimental Role
      Project
      Project Type
      Title
      References (36)