• Home
• Tools
  • Tools Overview
  • Query Tools

    
    • QuickSearch
    • QueryBuilder
    • TermLink
    • CytoSearch
    • Interactions Browser
    • ImageBrowse
    • Find A Person
    • Google™ FlyBase
  • Genomic/Map Tools

    
    • BLAST
    • GBrowse
    • CytoSearch
    • Aberrations Maps
    • Chromosome Maps
    • Coordinates Converter
  • Retrieve/Convert

    
    • Batch Download
    • Coordinates Converter
    • ID Converter
  • Data Submission

    
    • Fast-Track Your Paper
    • Submit Personal Comm
    • Add A New Person
    • Update Person Info
  • People

    
    • Find A Person
    • Add A New Person
    • Update Person Info
• Files
  • Files Overview
  • Downloads:
  • Precomputed files
  • Archived data
  • Releases (FTP)
  • Genomes (FTP)
  • AAA data (FTP)
  • Lists:
  • Transposons (Dmel)
  • Transposons (other)
  • Vectors & Constructs
  • Anatomical Terms
  • Map Conversion
• Species
  • Phylogeny
  • Sequenced Species
  • Synteny Table
  • Color Illustrations
  • Abbreviations
• Documents
  • About FlyBase
  • Reference Manual:
  • Sections
  • Contents
  • Nomenclature
  • Release Notes
• Resources
  • All Resources
  • Model Organisms
  • Stock Collections
  • Other links:
  • BDGP
  • DGRC
  • FlyExpress
  • Interactive Fly
  • modENCODE
  • Textpresso for Fly
• News
  • News
  • FlyBase Forum
  • FlyBase Positions
  • Meetings
  • Courses
  • Fly Board
  • White papers
  • Funding
  • bionet.dros
• Help
  • Google™ FlyBase
  • Site Map
  • FAQs
  • FlyBase Guides
  • Video Tutorials
  • Report help
  • New to Flies
  • Pers. comm.
  • Author guidelines
  • Contact FlyBase
• Archives
  • Prior Release
  • Other Archives
  • Coordinate Converter

Gene Dmel\Atg8b

General Information
Symbol	Dmel\Atg8b	Species	D. melanogaster
Name	Autophagy-specific gene 8b	Annotation symbol	CG12334
Feature type	protein_coding_gene	FlyBase ID	FBgn0038539
Gene Model Status	Current	Stock availability	4 publicly available
Also Known As	ATG8
Genomic Location
Chromosome (arm)	3R	Recombination map
Cytogenetic map	90C2-90C2	Sequence location	3R:13,550,146..13,550,766 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Autophagy-specific gene 8b is referred to in FlyBase by the symbol Dmel\Atg8b (CG12334, FBgn0038539). It is a protein_coding_gene from Drosophila melanogaster. Its molecular function is unknown. The biological processes in which it is involved are not known. 5 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: Autophagy protein Atg8 ubiquitin-like. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of no expression detected. Peak expression observed in adult male stages. Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult testis. Expression at moderate levels in the following post-embryonic organs or tissues: larval fat body. Comments on Affy2 ProbeSet: ProbeSet 1630629_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of Atg8b. Gene sequence location is 3R:13550146..13550766.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2012_01	Sequence features BKN30245 HFA14501
FB2011_10	Controlled Vocabulary Terms day 42 of adulthood day 41 of adulthood day 30 of adulthood day 49 of adulthood day 17 of adulthood day 45 of adulthood day 8 of adulthood day 26 of adulthood day 21 of adulthood day 13 of adulthood day 25 of adulthood day 22 of adulthood day 20 of adulthood day 39 of adulthood day 7 of adulthood day 36 of adulthood day 11 of adulthood day 37 of adulthood day 27 of adulthood day 18 of adulthood day 19 of adulthood day 28 of adulthood day 9 of adulthood day 29 of adulthood adult heart day 40 of adulthood day 16 of adulthood day 24 of adulthood day 15 of adulthood day 33 of adulthood day 43 of adulthood day 47 of adulthood day 38 of adulthood day 32 of adulthood day 48 of adulthood day 23 of adulthood day 35 of adulthood day 12 of adulthood day 10 of adulthood day 31 of adulthood day 34 of adulthood day 44 of adulthood day 14 of adulthood day 46 of adulthood
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 90C2-90C2   Limits computationally determined from genome sequence between P{PZ}l(3)0788207882 and P{EP}cpoEP3679
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Atg8b for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Atg8b-RA FBtr0083533  NM_142392   621   120
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Atg8b-PA   FBpp0082957   14.5   120   9.71     NP_650649   AAF55459
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Autophagy protein Atg8 ubiquitin-like (IPR004241)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014297 AAF55459   AI297572   AI944696   AI944718   AY069026 AAL39171   AY232215   BE976855   BE977754   BF492541   BF492542   BX012316   BX024259   BX028935   BX049446   BX057613   BX063659   CO180516   CO281244   EC199280
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q7K1J3 Q9VEG5
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 7 of adulthood -- day 49 of adulthood   adult heart   (Cammarato et al., 2011)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0038539    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0038539 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of no expression detected. Peak expression observed in adult male stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0038539 expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    16 embryo 04-06hr    5 embryo 06-08hr    4 embryo 08-10hr    10 embryo 10-12hr    2 embryo 12-14hr    1 embryo 14-16hr    5 embryo 16-18hr    5 embryo 18-20hr    0 embryo 20-22hr    7 embryo 22-24hr    5 larva L1    20 larva L2    2 larva L3 12hr old    7 larva L3 puffstage 1-2    479 larva L3 puffstage 3-6    1243 larva L3 puffstage 7-9    1608 white prepupae new    1375 white prepupae 12hr    2875 white prepupae 24hr    4193 pupae 2d postWPP    5421 pupae 3d postWPP    5112 pupae 4d postWPP    5444 adult male 01day    7785 adult male 05day    10327 adult male 30day    11614 adult female 01day    5 adult female 05day    0 adult female 30day    4 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    16 embryo 04-06hr    5 embryo 06-08hr    4 embryo 08-10hr    10 embryo 10-12hr    2 embryo 12-14hr    1 embryo 14-16hr    5 embryo 16-18hr    5 embryo 18-20hr    0 embryo 20-22hr    7 embryo 22-24hr    5 larva L1    20 larva L2    2 larva L3 12hr old    7 larva L3 puffstage 1-2  (479) larva L3 puffstage 3-6  (1243) larva L3 puffstage 7-9  (1608) white prepupae new  (1375) white prepupae 12hr  (2875) white prepupae 24hr  (4193) pupae 2d postWPP  (5421) pupae 3d postWPP  (5112) pupae 4d postWPP  (5444) adult male 01day  (7785) adult male 05day  (10327) adult male 30day  (11614) adult female 01day    5 adult female 05day    0 adult female 30day    4 Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    16 embryo 04-06hr    5 embryo 06-08hr    4 embryo 08-10hr    10 embryo 10-12hr    2 embryo 12-14hr    1 embryo 14-16hr    5 embryo 16-18hr    5 embryo 18-20hr    0 embryo 20-22hr    7 embryo 22-24hr    5 larva L1    20 larva L2    2 larva L3 12hr old    7 larva L3 puffstage 1-2    479 larva L3 puffstage 3-6    1243 larva L3 puffstage 7-9  (1608) white prepupae new    1375 white prepupae 12hr  (2875) white prepupae 24hr  (4193) pupae 2d postWPP  (5421) pupae 3d postWPP  (5112) pupae 4d postWPP  (5444) adult male 01day  (7785) adult male 05day  (10327) adult male 30day  (11614) adult female 01day    5 adult female 05day    0 adult female 30day    4 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    16 embryo 04-06hr    5 embryo 06-08hr    4 embryo 08-10hr    10 embryo 10-12hr    2 embryo 12-14hr    1 embryo 14-16hr    5 embryo 16-18hr    5 embryo 18-20hr    0 embryo 20-22hr    7 embryo 22-24hr    5 larva L1    20 larva L2    2 larva L3 12hr old    7 larva L3 puffstage 1-2    479 larva L3 puffstage 3-6    1243 larva L3 puffstage 7-9    1608 white prepupae new    1375 white prepupae 12hr    2875 white prepupae 24hr    4193 pupae 2d postWPP    5421 pupae 3d postWPP    5112 pupae 4d postWPP    5444 adult male 01day    7785 adult male 05day  10327 adult male 30day  (11614) adult female 01day    5 adult female 05day    0 adult female 30day    4 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    16 embryo 04-06hr    5 embryo 06-08hr    4 embryo 08-10hr    10 embryo 10-12hr    2 embryo 12-14hr    1 embryo 14-16hr    5 embryo 16-18hr    5 embryo 18-20hr    0 embryo 20-22hr    7 embryo 22-24hr    5 larva L1    20 larva L2    2 larva L3 12hr old    7 larva L3 puffstage 1-2    479 larva L3 puffstage 3-6    1243 larva L3 puffstage 7-9    1608 white prepupae new    1375 white prepupae 12hr    2875 white prepupae 24hr    4193 pupae 2d postWPP    5421 pupae 3d postWPP    5112 pupae 4d postWPP    5444 adult male 01day    7785 adult male 05day    10327 adult male 30day    11614 adult female 01day    5 adult female 05day    0 adult female 30day    4 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0038539 expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    16 embryo 04-06hr    5 embryo 06-08hr    4 embryo 08-10hr    10 embryo 10-12hr    2 embryo 12-14hr    1 embryo 14-16hr    5 embryo 16-18hr    5 embryo 18-20hr    0 embryo 20-22hr    7 embryo 22-24hr    5 larva L1    20 larva L2    2 larva L3 12hr old    7 larva L3 puffstage 1-2    479 larva L3 puffstage 3-6    1243 larva L3 puffstage 7-9    1608 white prepupae new    1375 white prepupae 12hr    2875 white prepupae 24hr    4193 pupae 2d postWPP    5421 pupae 3d postWPP    5112 pupae 4d postWPP    5444 adult male 01day    7785 adult male 05day    10327 adult male 30day    11614 adult female 01day    5 adult female 05day    0 adult female 30day    4 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    16 embryo 04-06hr    5 embryo 06-08hr    4 embryo 08-10hr    10 embryo 10-12hr    2 embryo 12-14hr    1 embryo 14-16hr    5 embryo 16-18hr    5 embryo 18-20hr    0 embryo 20-22hr    7 embryo 22-24hr    5 larva L1    20 larva L2    2 larva L3 12hr old    7 larva L3 puffstage 1-2  (479) larva L3 puffstage 3-6  (1243) larva L3 puffstage 7-9  (1608) white prepupae new  (1375) white prepupae 12hr  (2875) white prepupae 24hr  (4193) pupae 2d postWPP  (5421) pupae 3d postWPP  (5112) pupae 4d postWPP  (5444) adult male 01day  (7785) adult male 05day  (10327) adult male 30day  (11614) adult female 01day    5 adult female 05day    0 adult female 30day    4 Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    16 embryo 04-06hr    5 embryo 06-08hr    4 embryo 08-10hr    10 embryo 10-12hr    2 embryo 12-14hr    1 embryo 14-16hr    5 embryo 16-18hr    5 embryo 18-20hr    0 embryo 20-22hr    7 embryo 22-24hr    5 larva L1    20 larva L2    2 larva L3 12hr old    7 larva L3 puffstage 1-2    479 larva L3 puffstage 3-6    1243 larva L3 puffstage 7-9  1608 white prepupae new    1375 white prepupae 12hr  (2875) white prepupae 24hr  (4193) pupae 2d postWPP  (5421) pupae 3d postWPP  (5112) pupae 4d postWPP  (5444) adult male 01day  (7785) adult male 05day  (10327) adult male 30day  (11614) adult female 01day    5 adult female 05day    0 adult female 30day    4 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    16 embryo 04-06hr    5 embryo 06-08hr    4 embryo 08-10hr    10 embryo 10-12hr    2 embryo 12-14hr    1 embryo 14-16hr    5 embryo 16-18hr    5 embryo 18-20hr    0 embryo 20-22hr    7 embryo 22-24hr    5 larva L1    20 larva L2    2 larva L3 12hr old    7 larva L3 puffstage 1-2    479 larva L3 puffstage 3-6    1243 larva L3 puffstage 7-9    1608 white prepupae new    1375 white prepupae 12hr    2875 white prepupae 24hr    4193 pupae 2d postWPP    5421 pupae 3d postWPP    5112 pupae 4d postWPP    5444 adult male 01day    7785 adult male 05day  10327 adult male 30day  11614 adult female 01day    5 adult female 05day    0 adult female 30day    4 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    16 embryo 04-06hr    5 embryo 06-08hr    4 embryo 08-10hr    10 embryo 10-12hr    2 embryo 12-14hr    1 embryo 14-16hr    5 embryo 16-18hr    5 embryo 18-20hr    0 embryo 20-22hr    7 embryo 22-24hr    5 larva L1    20 larva L2    2 larva L3 12hr old    7 larva L3 puffstage 1-2    479 larva L3 puffstage 3-6    1243 larva L3 puffstage 7-9    1608 white prepupae new    1375 white prepupae 12hr    2875 white prepupae 24hr    4193 pupae 2d postWPP    5421 pupae 3d postWPP    5112 pupae 4d postWPP    5444 adult male 01day    7785 adult male 05day    10327 adult male 30day    11614 adult female 01day    5 adult female 05day    0 adult female 30day    4 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0038539    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0038539 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult testis. Expression at moderate levels in the following post-embryonic organs or tissues: larval fat body. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0038539 expression level Tissue   Expression Level Larval Central Nervous System    4.85 Larval Midgut    8.8 Larval Hindgut    9.3 Larval Malpighian Tubules    7.6 Larval Fat Body    197.3 Larval Salivary Gland    4.4 Larval Trachea no informative data Larval Carcass    7.675 Adult Head    7.4 Adult Eye    4.475 Adult Brain    4.2 Adult Thoracic-Abdominal Ganglion    5.4 Adult Crop    8.4 Adult Midgut    9 Adult Hindgut    19 Adult Malpighian Tubules    6.3 Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart    4.075 Adult VirginFemale Spermatheca    7.2 Adult InseminatedFemale Spermatheca    7.5 Adult Ovary    3.8 Adult Testis    1776.2 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    4.85 Larval Midgut    8.8 Larval Hindgut    9.3 Larval Malpighian Tubules    7.6 Larval Fat Body    197.3 Larval Salivary Gland    4.4 Larval Trachea no informative data Larval Carcass    7.675 Adult Head    7.4 Adult Eye    4.475 Adult Brain    4.2 Adult Thoracic-Abdominal Ganglion    5.4 Adult Crop    8.4 Adult Midgut    9 Adult Hindgut    19 Adult Malpighian Tubules    6.3 Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart    4.075 Adult VirginFemale Spermatheca    7.2 Adult InseminatedFemale Spermatheca    7.5 Adult Ovary    3.8 Adult Testis  (1776.2) Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    4.85 Larval Midgut    8.8 Larval Hindgut    9.3 Larval Malpighian Tubules    7.6 Larval Fat Body    197.3 Larval Salivary Gland    4.4 Larval Trachea no informative data Larval Carcass    7.675 Adult Head    7.4 Adult Eye    4.475 Adult Brain    4.2 Adult Thoracic-Abdominal Ganglion    5.4 Adult Crop    8.4 Adult Midgut    9 Adult Hindgut    19 Adult Malpighian Tubules    6.3 Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart    4.075 Adult VirginFemale Spermatheca    7.2 Adult InseminatedFemale Spermatheca    7.5 Adult Ovary    3.8 Adult Testis  (1776.2) Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    4.85 Larval Midgut    8.8 Larval Hindgut    9.3 Larval Malpighian Tubules    7.6 Larval Fat Body    197.3 Larval Salivary Gland    4.4 Larval Trachea no informative data Larval Carcass    7.675 Adult Head    7.4 Adult Eye    4.475 Adult Brain    4.2 Adult Thoracic-Abdominal Ganglion    5.4 Adult Crop    8.4 Adult Midgut    9 Adult Hindgut    19 Adult Malpighian Tubules    6.3 Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart    4.075 Adult VirginFemale Spermatheca    7.2 Adult InseminatedFemale Spermatheca    7.5 Adult Ovary    3.8 Adult Testis    1776.2 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0038539 expression level Tissue   Expression Level Larval Central Nervous System    4.85 Larval Midgut    8.8 Larval Hindgut    9.3 Larval Malpighian Tubules    7.6 Larval Fat Body    197.3 Larval Salivary Gland    4.4 Larval Trachea no informative data Larval Carcass    7.675 Adult Head    7.4 Adult Eye    4.475 Adult Brain    4.2 Adult Thoracic-Abdominal Ganglion    5.4 Adult Crop    8.4 Adult Midgut    9 Adult Hindgut    19 Adult Malpighian Tubules    6.3 Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart    4.075 Adult VirginFemale Spermatheca    7.2 Adult InseminatedFemale Spermatheca    7.5 Adult Ovary    3.8 Adult Testis    1776.2 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    4.85 Larval Midgut    8.8 Larval Hindgut    9.3 Larval Malpighian Tubules    7.6 Larval Fat Body    197.3 Larval Salivary Gland    4.4 Larval Trachea no informative data Larval Carcass    7.675 Adult Head    7.4 Adult Eye    4.475 Adult Brain    4.2 Adult Thoracic-Abdominal Ganglion    5.4 Adult Crop    8.4 Adult Midgut    9 Adult Hindgut    19 Adult Malpighian Tubules    6.3 Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart    4.075 Adult VirginFemale Spermatheca    7.2 Adult InseminatedFemale Spermatheca    7.5 Adult Ovary    3.8 Adult Testis  (1776.2) Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    4.85 Larval Midgut    8.8 Larval Hindgut    9.3 Larval Malpighian Tubules    7.6 Larval Fat Body    197.3 Larval Salivary Gland    4.4 Larval Trachea no informative data Larval Carcass    7.675 Adult Head    7.4 Adult Eye    4.475 Adult Brain    4.2 Adult Thoracic-Abdominal Ganglion    5.4 Adult Crop    8.4 Adult Midgut    9 Adult Hindgut    19 Adult Malpighian Tubules    6.3 Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart    4.075 Adult VirginFemale Spermatheca    7.2 Adult InseminatedFemale Spermatheca    7.5 Adult Ovary    3.8 Adult Testis  (1776.2) Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    4.85 Larval Midgut    8.8 Larval Hindgut    9.3 Larval Malpighian Tubules    7.6 Larval Fat Body    197.3 Larval Salivary Gland    4.4 Larval Trachea no informative data Larval Carcass    7.675 Adult Head    7.4 Adult Eye    4.475 Adult Brain    4.2 Adult Thoracic-Abdominal Ganglion    5.4 Adult Crop    8.4 Adult Midgut    9 Adult Hindgut    19 Adult Malpighian Tubules    6.3 Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart    4.075 Adult VirginFemale Spermatheca    7.2 Adult InseminatedFemale Spermatheca    7.5 Adult Ovary    3.8 Adult Testis    1776.2 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea no informative data Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland no informative data Adult Carcass no informative data FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    7.4   NA  Eye    4.475   NA  Brain    4.2   4.85  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    5.4   NA  Crop    8.4   8.8  Midgut    9   9.3  Hindgut    19   7.6  Malpighian Tubules    6.3   197.3  Fat Body    no informative data   4.4  Salivary Gland    no informative data   NA  Heart    4.075   no informative data  Trachea    NA   NA  VirginFemale Spermatheca    7.2   NA  InseminatedFemale Spermatheca    7.5   NA  Ovary    3.8   NA  Testis    1776.2   NA  Male Accessory Gland    no informative data   7.675  Carcass    no informative data modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_33
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0038539 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG12334-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable, with Scer\GAL4pnr-MD237 Atg8bGD7572 Phenotype manifest in Allele
Classical Alleles ( 0 )
For All Classical Alleles Show
Allele of Atg8b Class Mutagen Stocks Known lesion
Alleles Carried on Transgenic Constructs ( 5 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Atg8b Class Mutagen Stocks Known lesion Atg8bGD7572 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Atg8bHMS01245 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Atg8bJF02706 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Atg8bKK110245 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Atg8bhs.T:Avic\GFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 --
Aneuploid Aberrations
Disrupted in	Df(3R)Exel6177 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD7572} NA P{KK110245} NA P{TRiP.HMS01245} NA P{TRiP.JF02706} NA heat-shock construct P{hs-Atg8b.GFP} NA
Insertions
	Type of insertions Name Expression data
Gene Ontology: Function, Process & Cellular Component ( 0 unique terms )
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 0 terms )
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Atg8b allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 67164 DroID - A comprehensive database of gene and protein interactions. • FBgn0038539 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 42132
Orthologs
Genome-wide drosophilid orthologs	Dana\GF23138 Dere\GG16757 Dgri\GH15861 Dmoj\GI23636 Dper\GL12240 Dsec\GM15346 Dsim\GD20217 Dvir\GJ24711 Dwil\GK22506 Dyak\GE25252
Curated drosophilid orthologs	Dpse\GA11562
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • ENSCSAVP00000008559 Ciona savignyi (sedentary tunicate) DDB0191413 Dictyostelium discoideum (amoeba) 38111 Monocosta brevicollis (choanoflagellate) TA12615 Theileria annulata (apicomplexan parasite) TP02_0338 Theileria parva (parasitic protozoan) 3717.m00061 Tetrahymena thermophila (ciliate protozoa) 3825.m02850 Tetrahymena thermophila (ciliate protozoa) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • FBgn0242335 FBgn0224483 FBgn0211787 FBgn0191695 FBgn0170266 FBgn0244520 FBgn0071613 FBgn0149847 FBgn0146362 FBgn0123332 FBgn0108987 FBgn0100132
Stocks & Reagents
Stocks Listed in FlyBase ( 4 )
Bloomington	27554 y1 v1; P{TRiP.JF02706}attP2 34900 y1 sc* v1; P{TRiP.HMS01245}attP2
VDRC	v101922 P{KK110245}VIE-260B v17079 w1118; P{GD7572}v17079
Genomic Clones ( 2 )
	BACR14A01 BACR21K03 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 8 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	AT01047
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones
Other clones	39285 bs04c12 bs04e12 bs56g12 bs68f07 EC01991 EK156259
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0038539 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 42132
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: Atg8b CG12334 (Scott et al., 2004) Source for identity of: Atg8b CG12334 (Scott, 2005.3.2) Source for identity of: Atg8b CG12334 (Scott et al., 2004)
Source for database merge of
Additional comments	The Atg8b gene may have been derived from the Atg8a gene by retroposition. (Dai et al., 2006)
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_142392 RefSeq (Proteins) • NP_650649 DDBJ / EMBL / GenBank • AAF55459 AAL39171 AI297572 AI944696 AI944718 AY069026 BF492541 BF492542 Entrez Gene - A searchable database of RefSeq genes. • 42132 UniProtKB/TrEMBL • Q7K1J3 Q9VEG5
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Autophagy protein Atg8 ubiquitin-like (IPR004241)
Linkouts
	BioGRID - A database of protein and genetic interactions • 67164 DroID - A comprehensive database of gene and protein interactions. • FBgn0038539 DRSC - Results from RNAi screens. • FBgn0038539 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0038539 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG12334-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0038539 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 42132 InParanoid A subset of ortholog calls from InParanoid. • ENSCSAVP00000008559 Ciona savignyi (sedentary tunicate) DDB0191413 Dictyostelium discoideum (amoeba) 38111 Monocosta brevicollis (choanoflagellate) TA12615 Theileria annulata (apicomplexan parasite) TP02_0338 Theileria parva (parasitic protozoan) 3717.m00061 Tetrahymena thermophila (ciliate protozoa) 3825.m02850 Tetrahymena thermophila (ciliate protozoa) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 42132 modMine - Data generated by the modENCODE project. • FBgn0038539 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • FBgn0242335 FBgn0224483 FBgn0211787 FBgn0191695 FBgn0170266 FBgn0244520 FBgn0071613 FBgn0149847 FBgn0146362 FBgn0123332 FBgn0108987 FBgn0100132
Synonyms & Secondary IDs ( 11 )
Reported As
Symbol Synonym	ATG8 (Venkatachalam et al., 2008, Buchon et al., 2010) Atg8 (Midorikawa et al., 2010) ATG8b (Scott, 2005.3.2, Patel et al., 2009) Atg8b (Langille and Clark, 2007, Hou et al., 2008, Scott et al., 2007, Scott et al., 2007, Juhasz et al., 2007, Kim et al., 2010, Midorikawa et al., 2010, Francis et al., 2010) atg8b (Shelly et al., 2009) Atg8B (Liu et al., 2009) CG12334 (Betran et al., 2002, Dai et al., 2006, Juhasz et al., 2007, Keleman et al., 2009.8.5, Perkins et al., 2009, Ni et al., 2011.7.19, Cammarato et al., 2011) unnamed (Scott and Neufeld, 2003)
Name Synonym	autophagy related gene 8 (Buchon et al., 2010) Autophagy-specific gene 8b (Scott et al., 2004, Scott, 2005.3.2, Scott et al., 2004, Cammarato et al., 2011) autophagy-specific gene 8b (Patel et al., 2009)
Secondary FlyBase IDs
References ( 32 )
Generate a list of	All references relating to this gene ( 32 )
List References by type	Research paper  ( 16 ) Supplementary material  ( 6 ) Personal communication to FlyBase  ( 7 ) Abstract  ( 1 ) Computer file  ( 1 )
Recent research papers ( 4 )
	Buchon et al., 2010, BMC Biol. 8: 152 Drosophila EGFR pathway coordinates stem cell proliferation and gut remodeling following infection. [FBrf0212840] Francis et al., 2010, Curr. Biol. 20(20): 1799--1808 dDOR Is an EcR Coactivator that Forms a Feed-Forward Loop Connecting Insulin and Ecdysone Signaling. [FBrf0212109] Kim et al., 2010, BMC Cell Biol. 11: 9 A genetic screen for modifiers of Drosophila caspase Dcp-1 reveals caspase involvement in autophagy and novel caspase-related genes. [FBrf0209948] Midorikawa et al., 2010, J. Neurosci. 30(32): 10703--10719 Autophagy-dependent rhodopsin degradation prevents retinal degeneration in Drosophila. [FBrf0211516] Show all research papers ...