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Gene Dmel\Arp5

General Information
Symbol	Dmel\Arp5	Species	D. melanogaster
Name	Actin-related protein 5	Annotation symbol	CG7940
Feature type	protein_coding_gene	FlyBase ID	FBgn0038576
Gene Model Status	Current	Stock availability	3 publicly available
Genomic Location
Chromosome (arm)	3R	Recombination map
Cytogenetic map	90F6-90F6	Sequence location	3R:14,011,241..14,013,597 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Actin-related protein 5 is referred to in FlyBase by the symbol Dmel\Arp5 (CG7940, FBgn0038576). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: structural constituent of cytoskeleton. Based on sequence similarity, it is predicted to be involved in the biological process: cytoskeleton organization. 3 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: Actin-like. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 00-12 hour embryonic stages, in adult male stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval/adult central nervous system, adult ovary, adult testis. Comments on Affy2 ProbeSet: ProbeSet 1622928_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of Arp5. Gene sequence location is 3R:14011241..14013597.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2011_10
FB2012_01	Sequence features BKN20516 HFA16350
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 90F6-90F6   Limits computationally determined from genome sequence between P{EP}cpoEP3679 and P{EP}Dlc90FEP3634
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Arp5 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Arp5-RA FBtr0083557  NM_142427   2299   648
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Arp5-PA   FBpp0082979   75.1   648   7.14     NP_650684   AAF55504
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Actin-like (IPR004000)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA821007   AA990896   AE014297 AAF55504   AI106895   AI109259   AI135754   AI238162   AI238657   AI238683   AI455571   AI456258   AI456326   AI512453   AI512474   AI517854   AI518105   AI518375   AI519551   AI546158   AY069531 AAL39676   BF485941   BF492832   BF498653   BF499969   BF501442   BF503685   BF504247   BF505783   BG632429   BI164876   BI166406   BI233267   BI636361   BI636775   BQ103668   CK134863   CO310070   EC077153   EC202024   EC203194   EC224544   EC247029
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9VEC3
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0038576    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0038576 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 00-12 hour embryonic stages, in adult male stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0038576 expression level Developmental Stage   Expression Level embryo 00-02hr    1224 embryo 02-04hr    1794 embryo 04-06hr    1912 embryo 06-08hr    1889 embryo 08-10hr    1536 embryo 10-12hr    1255 embryo 12-14hr    968 embryo 14-16hr    802 embryo 16-18hr    585 embryo 18-20hr    405 embryo 20-22hr    478 embryo 22-24hr    512 larva L1    444 larva L2    468 larva L3 12hr old    348 larva L3 puffstage 1-2    462 larva L3 puffstage 3-6    697 larva L3 puffstage 7-9    724 white prepupae new    744 white prepupae 12hr    876 white prepupae 24hr    1140 pupae 2d postWPP    914 pupae 3d postWPP    772 pupae 4d postWPP    704 adult male 01day    1196 adult male 05day    1516 adult male 30day    1544 adult female 01day    654 adult female 05day    916 adult female 30day    927 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (1224) embryo 02-04hr  (1794) embryo 04-06hr  (1912) embryo 06-08hr  (1889) embryo 08-10hr  (1536) embryo 10-12hr  (1255) embryo 12-14hr  (968) embryo 14-16hr  (802) embryo 16-18hr  (585) embryo 18-20hr  (405) embryo 20-22hr  (478) embryo 22-24hr  (512) larva L1  (444) larva L2  (468) larva L3 12hr old  (348) larva L3 puffstage 1-2  (462) larva L3 puffstage 3-6  (697) larva L3 puffstage 7-9  (724) white prepupae new  (744) white prepupae 12hr  (876) white prepupae 24hr  (1140) pupae 2d postWPP  (914) pupae 3d postWPP  (772) pupae 4d postWPP  (704) adult male 01day  (1196) adult male 05day  (1516) adult male 30day  (1544) adult female 01day  (654) adult female 05day  (916) adult female 30day  (927) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    1224 embryo 02-04hr  (1794) embryo 04-06hr  (1912) embryo 06-08hr  (1889) embryo 08-10hr  (1536) embryo 10-12hr    1255 embryo 12-14hr    968 embryo 14-16hr    802 embryo 16-18hr    585 embryo 18-20hr    405 embryo 20-22hr    478 embryo 22-24hr    512 larva L1    444 larva L2    468 larva L3 12hr old    348 larva L3 puffstage 1-2    462 larva L3 puffstage 3-6    697 larva L3 puffstage 7-9    724 white prepupae new    744 white prepupae 12hr    876 white prepupae 24hr    1140 pupae 2d postWPP    914 pupae 3d postWPP    772 pupae 4d postWPP    704 adult male 01day    1196 adult male 05day  (1516) adult male 30day  (1544) adult female 01day    654 adult female 05day    916 adult female 30day    927 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    1224 embryo 02-04hr    1794 embryo 04-06hr    1912 embryo 06-08hr    1889 embryo 08-10hr    1536 embryo 10-12hr    1255 embryo 12-14hr    968 embryo 14-16hr    802 embryo 16-18hr    585 embryo 18-20hr    405 embryo 20-22hr    478 embryo 22-24hr    512 larva L1    444 larva L2    468 larva L3 12hr old    348 larva L3 puffstage 1-2    462 larva L3 puffstage 3-6    697 larva L3 puffstage 7-9    724 white prepupae new    744 white prepupae 12hr    876 white prepupae 24hr    1140 pupae 2d postWPP    914 pupae 3d postWPP    772 pupae 4d postWPP    704 adult male 01day    1196 adult male 05day    1516 adult male 30day    1544 adult female 01day    654 adult female 05day    916 adult female 30day    927 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    1224 embryo 02-04hr    1794 embryo 04-06hr    1912 embryo 06-08hr    1889 embryo 08-10hr    1536 embryo 10-12hr    1255 embryo 12-14hr    968 embryo 14-16hr    802 embryo 16-18hr    585 embryo 18-20hr    405 embryo 20-22hr    478 embryo 22-24hr    512 larva L1    444 larva L2    468 larva L3 12hr old    348 larva L3 puffstage 1-2    462 larva L3 puffstage 3-6    697 larva L3 puffstage 7-9    724 white prepupae new    744 white prepupae 12hr    876 white prepupae 24hr    1140 pupae 2d postWPP    914 pupae 3d postWPP    772 pupae 4d postWPP    704 adult male 01day    1196 adult male 05day    1516 adult male 30day    1544 adult female 01day    654 adult female 05day    916 adult female 30day    927 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0038576 expression level Developmental Stage   Expression Level embryo 00-02hr    1224 embryo 02-04hr    1794 embryo 04-06hr    1912 embryo 06-08hr    1889 embryo 08-10hr    1536 embryo 10-12hr    1255 embryo 12-14hr    968 embryo 14-16hr    802 embryo 16-18hr    585 embryo 18-20hr    405 embryo 20-22hr    478 embryo 22-24hr    512 larva L1    444 larva L2    468 larva L3 12hr old    348 larva L3 puffstage 1-2    462 larva L3 puffstage 3-6    697 larva L3 puffstage 7-9    724 white prepupae new    744 white prepupae 12hr    876 white prepupae 24hr    1140 pupae 2d postWPP    914 pupae 3d postWPP    772 pupae 4d postWPP    704 adult male 01day    1196 adult male 05day    1516 adult male 30day    1544 adult female 01day    654 adult female 05day    916 adult female 30day    927 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (1224) embryo 02-04hr  (1794) embryo 04-06hr  (1912) embryo 06-08hr  (1889) embryo 08-10hr  (1536) embryo 10-12hr  (1255) embryo 12-14hr  (968) embryo 14-16hr  (802) embryo 16-18hr  (585) embryo 18-20hr  (405) embryo 20-22hr  (478) embryo 22-24hr  (512) larva L1  (444) larva L2  (468) larva L3 12hr old  (348) larva L3 puffstage 1-2  (462) larva L3 puffstage 3-6  (697) larva L3 puffstage 7-9  (724) white prepupae new  (744) white prepupae 12hr  (876) white prepupae 24hr  (1140) pupae 2d postWPP  (914) pupae 3d postWPP  (772) pupae 4d postWPP  (704) adult male 01day  (1196) adult male 05day  (1516) adult male 30day  (1544) adult female 01day  (654) adult female 05day  (916) adult female 30day  (927) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    1224 embryo 02-04hr  1794 embryo 04-06hr  1912 embryo 06-08hr  1889 embryo 08-10hr  1536 embryo 10-12hr    1255 embryo 12-14hr    968 embryo 14-16hr    802 embryo 16-18hr    585 embryo 18-20hr    405 embryo 20-22hr    478 embryo 22-24hr    512 larva L1    444 larva L2    468 larva L3 12hr old    348 larva L3 puffstage 1-2    462 larva L3 puffstage 3-6    697 larva L3 puffstage 7-9    724 white prepupae new    744 white prepupae 12hr    876 white prepupae 24hr    1140 pupae 2d postWPP    914 pupae 3d postWPP    772 pupae 4d postWPP    704 adult male 01day    1196 adult male 05day  1516 adult male 30day  1544 adult female 01day    654 adult female 05day    916 adult female 30day    927 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    1224 embryo 02-04hr    1794 embryo 04-06hr    1912 embryo 06-08hr    1889 embryo 08-10hr    1536 embryo 10-12hr    1255 embryo 12-14hr    968 embryo 14-16hr    802 embryo 16-18hr    585 embryo 18-20hr    405 embryo 20-22hr    478 embryo 22-24hr    512 larva L1    444 larva L2    468 larva L3 12hr old    348 larva L3 puffstage 1-2    462 larva L3 puffstage 3-6    697 larva L3 puffstage 7-9    724 white prepupae new    744 white prepupae 12hr    876 white prepupae 24hr    1140 pupae 2d postWPP    914 pupae 3d postWPP    772 pupae 4d postWPP    704 adult male 01day    1196 adult male 05day    1516 adult male 30day    1544 adult female 01day    654 adult female 05day    916 adult female 30day    927 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    1224 embryo 02-04hr    1794 embryo 04-06hr    1912 embryo 06-08hr    1889 embryo 08-10hr    1536 embryo 10-12hr    1255 embryo 12-14hr    968 embryo 14-16hr    802 embryo 16-18hr    585 embryo 18-20hr    405 embryo 20-22hr    478 embryo 22-24hr    512 larva L1    444 larva L2    468 larva L3 12hr old    348 larva L3 puffstage 1-2    462 larva L3 puffstage 3-6    697 larva L3 puffstage 7-9    724 white prepupae new    744 white prepupae 12hr    876 white prepupae 24hr    1140 pupae 2d postWPP    914 pupae 3d postWPP    772 pupae 4d postWPP    704 adult male 01day    1196 adult male 05day    1516 adult male 30day    1544 adult female 01day    654 adult female 05day    916 adult female 30day    927 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0038576    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0038576 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval/adult central nervous system, adult ovary, adult testis. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0038576 expression level Tissue   Expression Level Larval Central Nervous System    151.625 Larval Midgut    39.3 Larval Hindgut    54.5 Larval Malpighian Tubules    43.1 Larval Fat Body no informative data Larval Salivary Gland    75 Larval Trachea    73.725 Larval Carcass    44.05 Adult Head    49.5 Adult Eye    50.875 Adult Brain    103.5 Adult Thoracic-Abdominal Ganglion    104.8 Adult Crop    47.4 Adult Midgut    39.3 Adult Hindgut    49.2 Adult Malpighian Tubules    56.1 Adult Fat Body no informative data Adult Salivary Gland    63.1 Adult Heart    25.15 Adult VirginFemale Spermatheca    65.4 Adult InseminatedFemale Spermatheca    66.8 Adult Ovary    107 Adult Testis    206.7 Adult Male Accessory Gland    76.2 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    151.625 Larval Midgut    39.3 Larval Hindgut    54.5 Larval Malpighian Tubules    43.1 Larval Fat Body no informative data Larval Salivary Gland    75 Larval Trachea    73.725 Larval Carcass    44.05 Adult Head    49.5 Adult Eye    50.875 Adult Brain    103.5 Adult Thoracic-Abdominal Ganglion    104.8 Adult Crop    47.4 Adult Midgut    39.3 Adult Hindgut    49.2 Adult Malpighian Tubules    56.1 Adult Fat Body no informative data Adult Salivary Gland    63.1 Adult Heart    25.15 Adult VirginFemale Spermatheca    65.4 Adult InseminatedFemale Spermatheca    66.8 Adult Ovary    107 Adult Testis    206.7 Adult Male Accessory Gland    76.2 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    151.625 Larval Midgut    39.3 Larval Hindgut    54.5 Larval Malpighian Tubules    43.1 Larval Fat Body no informative data Larval Salivary Gland    75 Larval Trachea    73.725 Larval Carcass    44.05 Adult Head    49.5 Adult Eye    50.875 Adult Brain    103.5 Adult Thoracic-Abdominal Ganglion    104.8 Adult Crop    47.4 Adult Midgut    39.3 Adult Hindgut    49.2 Adult Malpighian Tubules    56.1 Adult Fat Body no informative data Adult Salivary Gland    63.1 Adult Heart    25.15 Adult VirginFemale Spermatheca    65.4 Adult InseminatedFemale Spermatheca    66.8 Adult Ovary    107 Adult Testis    206.7 Adult Male Accessory Gland    76.2 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    151.625 Larval Midgut    39.3 Larval Hindgut    54.5 Larval Malpighian Tubules    43.1 Larval Fat Body no informative data Larval Salivary Gland    75 Larval Trachea    73.725 Larval Carcass    44.05 Adult Head    49.5 Adult Eye    50.875 Adult Brain    103.5 Adult Thoracic-Abdominal Ganglion    104.8 Adult Crop    47.4 Adult Midgut    39.3 Adult Hindgut    49.2 Adult Malpighian Tubules    56.1 Adult Fat Body no informative data Adult Salivary Gland    63.1 Adult Heart    25.15 Adult VirginFemale Spermatheca    65.4 Adult InseminatedFemale Spermatheca    66.8 Adult Ovary    107 Adult Testis    206.7 Adult Male Accessory Gland    76.2 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0038576 expression level Tissue   Expression Level Larval Central Nervous System    151.625 Larval Midgut    39.3 Larval Hindgut    54.5 Larval Malpighian Tubules    43.1 Larval Fat Body no informative data Larval Salivary Gland    75 Larval Trachea    73.725 Larval Carcass    44.05 Adult Head    49.5 Adult Eye    50.875 Adult Brain    103.5 Adult Thoracic-Abdominal Ganglion    104.8 Adult Crop    47.4 Adult Midgut    39.3 Adult Hindgut    49.2 Adult Malpighian Tubules    56.1 Adult Fat Body no informative data Adult Salivary Gland    63.1 Adult Heart    25.15 Adult VirginFemale Spermatheca    65.4 Adult InseminatedFemale Spermatheca    66.8 Adult Ovary    107 Adult Testis    206.7 Adult Male Accessory Gland    76.2 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    151.625 Larval Midgut    39.3 Larval Hindgut    54.5 Larval Malpighian Tubules    43.1 Larval Fat Body no informative data Larval Salivary Gland    75 Larval Trachea    73.725 Larval Carcass    44.05 Adult Head    49.5 Adult Eye    50.875 Adult Brain    103.5 Adult Thoracic-Abdominal Ganglion    104.8 Adult Crop    47.4 Adult Midgut    39.3 Adult Hindgut    49.2 Adult Malpighian Tubules    56.1 Adult Fat Body no informative data Adult Salivary Gland    63.1 Adult Heart    25.15 Adult VirginFemale Spermatheca    65.4 Adult InseminatedFemale Spermatheca    66.8 Adult Ovary    107 Adult Testis    206.7 Adult Male Accessory Gland    76.2 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    151.625 Larval Midgut    39.3 Larval Hindgut    54.5 Larval Malpighian Tubules    43.1 Larval Fat Body no informative data Larval Salivary Gland    75 Larval Trachea    73.725 Larval Carcass    44.05 Adult Head    49.5 Adult Eye    50.875 Adult Brain    103.5 Adult Thoracic-Abdominal Ganglion    104.8 Adult Crop    47.4 Adult Midgut    39.3 Adult Hindgut    49.2 Adult Malpighian Tubules    56.1 Adult Fat Body no informative data Adult Salivary Gland    63.1 Adult Heart    25.15 Adult VirginFemale Spermatheca    65.4 Adult InseminatedFemale Spermatheca    66.8 Adult Ovary    107 Adult Testis    206.7 Adult Male Accessory Gland    76.2 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    151.625 Larval Midgut    39.3 Larval Hindgut    54.5 Larval Malpighian Tubules    43.1 Larval Fat Body no informative data Larval Salivary Gland    75 Larval Trachea    73.725 Larval Carcass    44.05 Adult Head    49.5 Adult Eye    50.875 Adult Brain    103.5 Adult Thoracic-Abdominal Ganglion    104.8 Adult Crop    47.4 Adult Midgut    39.3 Adult Hindgut    49.2 Adult Malpighian Tubules    56.1 Adult Fat Body no informative data Adult Salivary Gland    63.1 Adult Heart    25.15 Adult VirginFemale Spermatheca    65.4 Adult InseminatedFemale Spermatheca    66.8 Adult Ovary    107 Adult Testis    206.7 Adult Male Accessory Gland    76.2 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body no informative data Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body no informative data Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass no informative data FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    49.5   NA  Eye    50.875   NA  Brain    103.5   151.625  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    104.8   NA  Crop    47.4   39.3  Midgut    39.3   54.5  Hindgut    49.2   43.1  Malpighian Tubules    56.1   no informative data  Fat Body    no informative data   75  Salivary Gland    63.1   NA  Heart    25.15   73.725  Trachea    NA   NA  VirginFemale Spermatheca    65.4   NA  InseminatedFemale Spermatheca    66.8   NA  Ovary    107   NA  Testis    206.7   NA  Male Accessory Gland    76.2   44.05  Carcass    no informative data modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_21
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0038576 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG7940-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for Arp5 Stages(s) 1-3 Stages(s) 4-6 Stages(s) 7-8 Stages(s) 9-10 Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable, with Scer\GAL4pnr-MD237 Arp5GD12324 Phenotype manifest in Allele
Classical Alleles ( 0 )
For All Classical Alleles Show
Allele of Arp5 Class Mutagen Stocks Known lesion
Alleles Carried on Transgenic Constructs ( 3 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Arp5 Class Mutagen Stocks Known lesion Arp5GD12324 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes Arp5HMS00809 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Arp5KK100420 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3R)Exel6178 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD12328} NA P{KK100420} NA P{TRiP.HMS00809} NA
Insertions
	Type of insertions Name Expression data
Gene Ontology: Function, Process & Cellular Component ( 4 unique terms )
Terms Based on Experimental Evidence ( 1 term )
Molecular Function ( 0 terms)
Biological Process ( 0 terms)
Cellular Component
CV term Evidence References
Ino80 complex inferred from direct assay (Klymenko et al., 2006)
Terms Based on Predictions or Assertions ( 3 terms )
Molecular Function
CV term Evidence References
structural constituent of cytoskeleton inferred from sequence or structural similarity with NCBI_gi:1730738 (Goldstein and Gunawardena, 2000)
Biological Process
CV term Evidence References
cytoskeleton organization inferred from sequence or structural similarity with NCBI_gi:1730738 (Goldstein and Gunawardena, 2000)
Cellular Component
CV term Evidence References
actin filament inferred from sequence or structural similarity with NCBI_gi:1730738 (Goldstein and Gunawardena, 2000)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Arp5 allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 67194 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0038576 DroID - A comprehensive database of gene and protein interactions. • FBgn0038576 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 42173
Orthologs
Genome-wide drosophilid orthologs	Dana\GF18509 Dere\GG22693 Dgri\GH15134 Dmoj\GI23721 Dper\GL12594 Dpse\GA20705 Dsec\GM15282 Dsim\GD19207 Dvir\GJ23279 Dwil\GK17159 Dyak\GE25517
Curated drosophilid orthologs	Dpse\GA20705
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL002822-PA Aedes aegypti (mosquito) AGAP004488-PA Anopheles gambiae (mosquito) XP_623919.1 Apis mellifera (honey bee) XP_001947910.1 Acyrthosiphon pisum (pea aphid) At3g12380.1 Arabidopsis thaliana (wall cress) 127578 Branchiostoma floridae (lancelet) BGIBMGA008880-PA Bombyx mori (silk worm) CAL0000047 Candida albicans (a form of yeast) ENSCAFP00000013239 Canis familiaris (dog) CAGL0J10054g Candida glabrata (haploid yeast) cn11171 Cryptococcus neoformans (yeast-like fungus) CPIJ003226 Culex pipens (mosquito) ENSCPOP00000010371 Cavia porcellus (guinea pig) 223173 Capitella spl (polychaete worm) DDB0234009 Dictyostelium discoideum (amoeba) DEHA2F21076g Debaryomyces Hansenii (yeast) 301936 Daphnia pulex (daphnia) ENSDARP00000012660 Danio rerio (zebra fish) ENSECAP00000022317 Equus caballus (horse) ENSGACP00000008271 Gymnopilus aculeatus (mushroom) ENSGALP00000005624 Gallus gallus (chicken) GL50803_11039 Giardia lamblia (flagellated protozoan) 70073 Hypsipyla robusta (cedar shoot borer) ENSP00000243903 Homo sapiens (human) KLLA0F03421g Kluyveromyces lactis (yeast) 136147 Lottia gigantea (owl limpet) 26907 Monocosta brevicollis (choanoflagellate) ENSMODP00000000525 Monodelphis domestica (gray opossum) ENSMMUP00000004502 Macaca mulatta (rhesus monkey) ENSMUSP00000046658 Mus musculus (house mouse) XP_001606978.1 Nasonia vitripennis (wasp) ENSORLP00000004738 Oryzias latipes (japanese killifish) PHUM003146-PA Pediculus humanus (human body louse) 149956 Physcomitrella patens (moss) ENSPPYP00000012289 Pongo pygmaeus (orangutan) 227426 Populus trichocarpa (black cottonwood) ENSPTRP00000023164 Pan troglodytes (chimpanzee) ENSRNOP00000036100 Rattus norvegicus (norway rat) 4751205 Sorghum bicolor (sorghum) YNL059C Saccharomyces cerevisiae (budding yeast) Smp_125790 Schistosoma mansoni (trematode parasite) SPBC365.10 Schizosaccharomyces pombe (fission yeast) XP_001191652.1 Strongylocentrotus purpuratus (purple sea urchin) 20693 Trichoplax adhaerens (metazoa) XP_967597.1 Tribolium castaneum (red flour beetle) ENSTNIP00000014967 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000008211 Takifugu rubripes (pufferfish Takifugu) 3698.m00041 Tetrahymena thermophila (ciliate protozoa) ENSXETP00000026492 Xenopus tropicalis (frog) YALI0B10538g Yarrowia lipolytica (nonconventional yeast) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB17261 NV11745 LH22382 ISCW012075 FBgn0242583 FBgn0219158 FBgn0210381 FBgn0190712 FBgn0170202 JGI_V11_301936 FBgn0080696 FBgn0150200 FBgn0146446 FBgn0122609 FBgn0114858 FBgn0095527 CPIJ003226 BGIBMGA008880 ACYPI004635 GB16783 AGAP004488 ARP5_AEDAE PHUM332110 GLEAN_09219
Stocks & Reagents
Stocks Listed in FlyBase ( 3 )
Bloomington	33009 y1 sc* v1; P{TRiP.HMS00809}attP2
VDRC	v22633 w1118; P{GD12324}v22633 v22634 w1118; P{GD12324}v22634
Genomic Clones ( 2 )
	BACR03J17 BACR27G04 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 39 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD24983
Other clones	DPiM_LD24983
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT01231 AT04860 AT05566 AT08164 AT13087 AT14755 AT16779 AT20039 GH06149 GH13620 GH14163 LD34407 LD36148 LD36255 LD37866 LD39178 LD42961 LD44333 LD44359 LD46255 RE04640 RE06524 RE29568 RH05020 SD18012 SD18592
Other clones	72093 77797 97709 122389 122633 EK220358 GH08392 GH14742 GH14772 LD37526 UUGC1078
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0038576 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 42173
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: Arp5 CG7940 (Klymenko et al., 2006)
Source for database merge of
Additional comments
Other Comments
	dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology. (Kiger et al., 2003)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_142427 RefSeq (Proteins) • NP_650684 DDBJ / EMBL / GenBank • AA821007 AAF55504 AAL39676 AI455571 AY069531 Entrez Gene - A searchable database of RefSeq genes. • 42173 UniProtKB/TrEMBL • Q9VEC3
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Actin-like (IPR004000)
Linkouts
	BioGRID - A database of protein and genetic interactions • 67194 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0038576 DroID - A comprehensive database of gene and protein interactions. • FBgn0038576 DRSC - Results from RNAi screens. • FBgn0038576 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0038576 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG7940-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0038576 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 42173 InParanoid A subset of ortholog calls from InParanoid. • AAEL002822-PA Aedes aegypti (mosquito) AGAP004488-PA Anopheles gambiae (mosquito) XP_623919.1 Apis mellifera (honey bee) XP_001947910.1 Acyrthosiphon pisum (pea aphid) At3g12380.1 Arabidopsis thaliana (wall cress) 127578 Branchiostoma floridae (lancelet) BGIBMGA008880-PA Bombyx mori (silk worm) CAL0000047 Candida albicans (a form of yeast) ENSCAFP00000013239 Canis familiaris (dog) CAGL0J10054g Candida glabrata (haploid yeast) cn11171 Cryptococcus neoformans (yeast-like fungus) CPIJ003226 Culex pipens (mosquito) ENSCPOP00000010371 Cavia porcellus (guinea pig) 223173 Capitella spl (polychaete worm) DDB0234009 Dictyostelium discoideum (amoeba) DEHA2F21076g Debaryomyces Hansenii (yeast) 301936 Daphnia pulex (daphnia) ENSDARP00000012660 Danio rerio (zebra fish) ENSECAP00000022317 Equus caballus (horse) ENSGACP00000008271 Gymnopilus aculeatus (mushroom) ENSGALP00000005624 Gallus gallus (chicken) GL50803_11039 Giardia lamblia (flagellated protozoan) 70073 Hypsipyla robusta (cedar shoot borer) ENSP00000243903 Homo sapiens (human) KLLA0F03421g Kluyveromyces lactis (yeast) 136147 Lottia gigantea (owl limpet) 26907 Monocosta brevicollis (choanoflagellate) ENSMODP00000000525 Monodelphis domestica (gray opossum) ENSMMUP00000004502 Macaca mulatta (rhesus monkey) ENSMUSP00000046658 Mus musculus (house mouse) XP_001606978.1 Nasonia vitripennis (wasp) ENSORLP00000004738 Oryzias latipes (japanese killifish) PHUM003146-PA Pediculus humanus (human body louse) 149956 Physcomitrella patens (moss) ENSPPYP00000012289 Pongo pygmaeus (orangutan) 227426 Populus trichocarpa (black cottonwood) ENSPTRP00000023164 Pan troglodytes (chimpanzee) ENSRNOP00000036100 Rattus norvegicus (norway rat) 4751205 Sorghum bicolor (sorghum) YNL059C Saccharomyces cerevisiae (budding yeast) Smp_125790 Schistosoma mansoni (trematode parasite) SPBC365.10 Schizosaccharomyces pombe (fission yeast) XP_001191652.1 Strongylocentrotus purpuratus (purple sea urchin) 20693 Trichoplax adhaerens (metazoa) XP_967597.1 Tribolium castaneum (red flour beetle) ENSTNIP00000014967 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000008211 Takifugu rubripes (pufferfish Takifugu) 3698.m00041 Tetrahymena thermophila (ciliate protozoa) ENSXETP00000026492 Xenopus tropicalis (frog) YALI0B10538g Yarrowia lipolytica (nonconventional yeast) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 42173 modMine - Data generated by the modENCODE project. • FBgn0038576 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB17261 NV11745 LH22382 ISCW012075 FBgn0242583 FBgn0219158 FBgn0210381 FBgn0190712 FBgn0170202 JGI_V11_301936 FBgn0080696 FBgn0150200 FBgn0146446 FBgn0122609 FBgn0114858 FBgn0095527 CPIJ003226 BGIBMGA008880 ACYPI004635 GB16783 AGAP004488 ARP5_AEDAE PHUM332110 GLEAN_09219
Synonyms & Secondary IDs ( 4 )
Reported As
Symbol Synonym	Arp5   CG7940 (Klymenko et al., 2006, Bakal et al., 2007, Ni et al., 2010.12.1, Keleman et al., 2009.8.5) dArp5 (Klymenko et al., 2006)
Name Synonym	Actin-related protein 5   CG7940
Secondary FlyBase IDs
References ( 16 )
Research paper	Klymenko et al., 2006, Genes Dev. 20(9): 1110--1122 A Polycomb group protein complex with sequence-specific DNA-binding and selective methyl-lysine-binding activities. [FBrf0190547] Asha et al., 2003, Genetics 163(1): 203--215 Analysis of ras-induced overproliferation in Drosophila hemocytes. [FBrf0155813]
Supplementary material	The modENCODE Consortium, 2010, Science 330(6012): DataS14: Gene co-expression clusters. [FBrf0213979] Mummery-Widmer et al., 2009, Nature 458(7241): Supplementary Table 2 - Genome-wide bristle screen results. [FBrf0214518] Bakal et al., 2007, Science 316(5832): Supporting online material. [FBrf0204776] Giot et al., 2003, Science 302(5651): Tables S1 to S7. [FBrf0166452] Kiger et al., 2003, J. Biol. 2(4): Additional data file 1: The gene identity and primer sequences for dsRNAs used in the RNAi screens. [FBrf0174231] Goldstein and Gunawardena, 2000, J. Cell Biol. 150(2): Table S2. Identified cytoskeletal protein coding genes in Drosophila. [FBrf0132100]
Personal communication to FlyBase	Ni et al., 2010.12.1, A genome-scale shRNA resource for transgenic RNAi in Drosophila. A genome-scale shRNA resource for transgenic RNAi in Drosophila. [FBrf0212437] Keleman et al., 2009.8.5, RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0208510] Dickson et al., 2007.7.18, RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0200327] FlyBase Curators et al., 2004-, Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. [FBrf0174215] Ryder, 2004.4.26, Exelixis CG deletion data. Exelixis CG deletion data. [FBrf0184335]
Computer file	BDGP Project Members, 2000-, Berkeley Drosophila Genome Project. Berkeley Drosophila Genome Project. [FBrf0125078]
Automatic genome annotation	FamiliarityBreedsContempt, 1999.11, [Annotations performed at the Celera Jamboreee.] [Annotations performed at the Celera Jamboreee.] [FBrf0126705]
Curated genome annotation	Goldstein, 1999.11, [Annotations performed at the Celera Jamboreee.] [Annotations performed at the Celera Jamboreee.] [FBrf0126668]